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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SYT11 Gene

protein-coding   GIFtS: 59
GCID: GC01P155829

synaptotagmin XI
 Explore 3 diseases affiliated with
SYT11 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SYT11    

Aliases
for SYT11 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Synaptotagmin XI1 2 3     SYT122
KIAA00801 3     Synaptotagmin 122
DKFZp781D0151     Synaptotagmin-111
MGC108811     SytXI3
MGC172261     SytXI3

External Ids:    HGNC: 192391   Entrez Gene: 232082   Ensembl: ENSG000001327187   OMIM: 6087415   UniProtKB: Q9BT883   

Export aliases for SYT11 gene to outside databases

Previous GC identifers: GC01U990248 GC01P151576 GC01P152607 GC01P153046 GC01P152642 GC01P154095 GC01P127190


Summaries
for SYT11 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SYT11:
This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that are
known calcium sensors and mediate calcium-dependent regulation of membrane trafficking in synaptic transmission. The
encoded protein is also a substrate for ubiquitin-E3-ligase parkin. The gene has previously been referred to as
synaptotagmin XII but has been renamed synaptotagmin XI to be consistent with mouse and rat official nomenclature.
(provided by RefSeq, Apr 2010)

UniProtKB/Swiss-Prot: SYT11_HUMAN, Q9BT88
Function: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding
to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis (By similarity)

Gene Wiki entry for SYT11


Genomic Views
for SYT11 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SYT11 gene promoter:
         RFX1   Pax-5   AP-4   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   YY1   POU2F1   POU2F1a   c-Myb   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SYT11 promoter sequence
   Search SABiosciences Chromatin IP Primers for SYT11

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SYT11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.2   Ensembl cytogenetic band:  1q22   HGNC cytogenetic band: 1q22

SYT11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SYT11 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P155829:  view genomic region     (about GC identifiers)

Start:
 155,829,260 bp from pter      End:
 155,854,990 bp from pter
Size:
 25,731 bases      Orientation:
 plus strand

Proteins
for SYT11 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SYT11_HUMAN, Q9BT88 (See protein sequence)
Recommended Name: Synaptotagmin-11  
Size: 431 amino acids; 48297 Da
Cofactor: Binds 3 calcium ions per subunit. The ions are bound to the C2 domains (By similarity)
Subunit: Homodimer. Can also form heterodimers (By similarity). Interacts with PARK2
Subcellular location: Membrane; Single-pass membrane protein. Cell junction, synapse (By similarity). Cytoplasmic
vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein (By similarity). Note=In
substantia nigra, observed in neuronal cell bodies and neurites. Found in the core of the Lewy bodies in the brain of
sporadic Parkinson disease patients
Sequence caution: Sequence=BAA07527.2; Type=Erroneous initiation;
Secondary accessions: Q14998 Q5W0D4 Q68CT5 Q8IXU3 Q96SU2

Explore the universe of human proteins at neXtProt for SYT11: NX_Q9BT88

Post-translational modifications:

  • Ubiquitinated and targeted to the proteasome complex for degradation1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9BT88

    • SYT11 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_689493.3  
    ENSEMBL proteins: 
     ENSP00000357307   ENSP00000441657  

    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: SYT11
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    Novus Biologicals SYT11 Protein
    Novus Biologicals SYT11 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SYT11

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral to plasma membrane IEA--
    GO:0008021synaptic vesicle ----
    GO:0030054cell junction IEA--
    GO:0030672synaptic vesicle membrane IEA--


    SYT11 for ontologies           About GeneDecksing



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    Uscn Antibodies for SYT11
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    Uscn ELISAs and CLIAs for SYT11

    Protein Domains /
    Families
    for SYT11 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SYT11 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR008973 C2_Ca/lipid-bd_dom_CaLB
     IPR001565 Synaptotagmin
     IPR018029 C2_membr_targeting
     IPR000008 C2_Ca-dep

    Graphical View of Domain Structure for InterPro Entry Q9BT88

    ProtoNet protein and cluster: Q9BT88

    1 Blocks protein family: IPB000008 C2 domain

    UniProtKB/Swiss-Prot: SYT11_HUMAN, Q9BT88
    Similarity: Belongs to the synaptotagmin family
    Similarity: Contains 2 C2 domains


    Function
    for SYT11 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SYT11_HUMAN, Q9BT88
    Function: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding
    to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis (By similarity)

    miRNA
    Products:            		 OriGene 3'-UTR Clone: SYT11
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SYT11
    8/107 QIAGEN miScript miRNA Assays for microRNAs that regulate SYT11 (see all 107):
    hsa-miR-579 hsa-miR-1321 hsa-miR-642a hsa-miR-300 hsa-miR-134 hsa-miR-371-5p hsa-miR-3916 hsa-miR-525-3p
    SwitchGear 3'UTR luciferase reporter plasmid: SYT11 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SYT11 (see all 7)
    OriGene shRNA RFP: SYT11
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    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SYT11

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SYT11 (see all 4)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYT11 

    Cell Line
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    Search LifeMap BioReagents cell lines for SYT11

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYT11

    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity IEA--
    GO:0005509calcium ion binding ----
    GO:0005515protein binding IPI--
    GO:0005544calcium-dependent phospholipid binding ----
    GO:0046872metal ion binding IEA--


    SYT11 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for SYT11:
     Elongated cells  Synthetic lethal with imatinib 

    Animal Models:
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Syt11):
     normal 

    SYT11 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SYT11 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Parkinsons Disease Pathway
    		Parkinsons Disease Pathway1.00
    2Ubiquitinated Orc1 is degraded by the proteasome
    		Parkinson's Disease Pathway0.31

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for SYT11
        Parkinson's Disease Pathway

    1 BioSystems Pathway for SYT11 
        Parkinsons Disease Pathway


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SYT11

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5/8 Interacting proteins for SYT11 (Q9BT881, 2, 3 ENSP000003573074) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APPBP2Q926241, 2, 3, ENSP000000831824EBI-751770,EBI-743771 MINT-68271 I2D: score=5 STRING: ENSP00000083182
    CSNK1A1P487292, 3, ENSP000002617984MINT-17245 I2D: score=1 STRING: ENSP00000261798
    PARK2O602603, ENSP000003558654I2D: score=2 STRING: ENSP00000355865
    SYNCRIPO605063, ENSP000003586354I2D: score=2 STRING: ENSP00000358635
    MEOX2P502223I2D: score=1 
    About this table

    Drugs & Compounds
    for SYT11 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SYT11 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SYT11

    1 HMDB Compound for SYT11    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    1 Novoseek chemical compound relationship for SYT11 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcium 8.92 2 17192956 (1)

    Search CenterWatch for drugs/clinical trials and news about SYT11 

    Transcripts
    for SYT11 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SYT11 gene: 
    NM_152280.4  

    Unigene Cluster for SYT11:

    Synaptotagmin XI
    Hs.32984  [show with all ESTs]
    Unigene Representative Sequence: NM_152280
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368324(uc001fmg.3 uc010pgq.2) ENST00000539162

    miRNA
    Products:             		 OriGene 3'-UTR Clone: SYT11
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SYT11
    8/107 QIAGEN miScript miRNA Assays for microRNAs that regulate SYT11 (see all 107):
    hsa-miR-579 hsa-miR-1321 hsa-miR-642a hsa-miR-300 hsa-miR-134 hsa-miR-371-5p hsa-miR-3916 hsa-miR-525-3p
    SwitchGear 3'UTR luciferase reporter plasmid: SYT11 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SYT11 (see all 7)
    OriGene shRNA RFP: SYT11
    Browse OriGene siRNA
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    Clone
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    GenScript: all cDNA clones in your preferred vector: SYT11 (NM_152280)
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SYT11

    Additional cDNA sequence: 

    AK021924.1 AK026178.1 AK027540.1 AK074931.1 AK296378.1 BC004291.1 BC013690.1 BC039205.1 
    CR749792.1 

    18 DOTS entries:

    DT.453243  DT.95271113  DT.100885367  DT.91956546  DT.121381478  DT.95271111  DT.121381286  DT.101977430 
    DT.100775452  DT.100833393  DT.121381426  DT.107869  DT.100885352  DT.121381162  DT.121381274  DT.121381160 
    DT.91765021  DT.95085591 

    24/283 AceView cDNA sequences (see all 283):

    AA909981 AI809261 Z45864 AA429657 BQ893416 AI700596 AA765362 F02554 
    BM836331 BE465024 T33517 CA437943 AI014322 AI281489 N32969 AU131667 
    F05877 BM759839 CK905670 T08460 AK026178 AI144292 BM693499 F02124 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for SYT11    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b
    SP1:                                -               
    SP2:                                                
    SP3:                                -               


    ECgene alternative splicing isoforms for SYT11

    Expression
    for SYT11 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SYT11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AATTGTGTGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SYT11 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeInner Nuclear LayerMature Horizontal CellsHorizontal, Retina
    Gut TubeForegutForegut Endoderm CellsEndoderm
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 10 LifeMap Cells 
    NameCategory
    PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ mesenchymal progenitor E15 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ progenitor EN27 (Embryonic Progenitor Cell)
    PureStem™ progenitor EN7 (Embryonic Progenitor Cell)
    PureStem™ progenitor F15 (Embryonic Progenitor Cell)
    PureStem™ progenitor SM22 (Embryonic Progenitor Cell)
    PureStem™ progenitor U31 (Embryonic Progenitor Cell)
    PureStem™ progenitor Z1 (Embryonic Progenitor Cell)
    Fetal cardiomyocytes (20 weeks) (Primary Cell)Heart, Myocardium
    Mature follicles (In-vitro growth and ...)

    See SYT11 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SYT11

    SOURCE GeneReport for Unigene cluster: Hs.32984
        SABiosciences Expression via Pathway-Focused PCR Array including SYT11: 
              Parkinson's Disease in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYT11

    Orthologs
    for SYT11 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for SYT11 gene from 5/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SYT111 synaptotagmin XI 78.63(n)
    88.34(a)    		   429166  XM_426721.3  XP_426721.3 
    lizard
    (Anolis carolinensis)    		 Reptilia SYT116
    		 --
    		 87(a)
    		 1 ↔ 1
    		 GL343519.1(440899-446199)
    zebrafish
    (Danio rerio)    		 Actinopterygii BC044424.12   -- 81.24(n)    BC044424.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Syt41 Synaptotagmin 4 58.33(n)
    51.74(a)    		   40876  NM_058116.4  NP_477464.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea snt-46
    snt-66
    		 SyNapTotagmin family member (snt-6)
    		 29(a)
    28(a)
    		 1 ↔ many
    possible ortholog
    		 I(6436045-6441193)
    II(745469-750171)


    ENSEMBL Gene Tree for SYT11 (if available)
    TreeFam Gene Tree for SYT11 (if available) 

    Paralogs
    for SYT11 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SYT11 gene
    SYT152  SYT42  SYT52  SYT82  SYT92  SYT32  SYT102  SYT62  
    SYT172  SYT122  SYT72  SYT22  SYT12  
    18/20 SIMAP similar genes for SYT11 using alignment to 2 protein entries:     SYT11_HUMAN (see all proteins) (see all similar genes):
    SYT4    PRKCG    SYT5    SYT10    SYT2    SYT7
    SYT1    SYT9    PRKCB    SYT6    PRKCA    SYT8
    SYTL4    SYT17    DOC2A    PCLO    ESYT2    CHR11SYT

    SYT11 for paralogs           About GeneDecksing



    Genomic Variants
    for SYT11 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/402 NCBI SNPs in SYT11 are shown (see all 402)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs113379011,2
    		C,F--127207464(+) ATTTC-/TTTTTT 1 -- int1 trp33Minor allele frequency- T:0.33NA CSA 6
    rs1832765051,2
    		--155827371(+) CAAAAC/TTAGCT 3 -- us2k10--------
    rs17494131,2
    		C,A,H,--155827458(-) ACTGCA/CACCTC 3 -- us2k19Minor allele frequency- C:0.00NA WA CSA 19
    rs665388741,2
    		C--155827518(-) TTTTT-/TGATAC 3 -- us2k11Minor allele frequency- T:0.00NA 2
    rs75565191,2
    		C,F,A,H,--155827546(+) TAATTT/CTTCTC 3 -- us2k110Minor allele frequency- C:0.45NA WA EA 510
    rs1436224651,2
    		--155827561(+) CGAGTC/TACCTG 3 -- us2k10--------
    rs1875205991,2
    		--155827634(+) AAATAC/GTGCAG 3 -- us2k10--------
    rs120953731,2
    		C,F,H,--155827784(+) TCATAT/CTCCAG 3 -- us2k121Minor allele frequency- C:0.06NA NS EA WA 2058
    rs1472024711,2
    		--155827981(+) AATGAA/GTGAAT 3 -- us2k10--------
    rs741164341,2
    		C,--155828067(+) AAAAAC/TAGAAT 3 -- us2k12Minor allele frequency- T:0.19WA 120

    HapMap Linkage Disequilibrium report for SYT11 (155829260 - 155854990 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for SYT11
         1 CNV: 6789
    Human Gene Mutation Database (HGMD): SYT11

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    Disorders / Diseases
    for SYT11 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SYT11 for disorders           About GeneDecksing

    OMIM gene information: 608741    OMIM disorders: --

    3 diseases for SYT11:    About MalaCards
    autosomal recessive juvenile parkinson disease    parkinson's disease    schizophrenia

    1 Novoseek disease relationship for SYT11 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    schizophrenia 31 5 17192956 (4), 15777718 (1)

    Human Genome Epidemiology (HuGE) Navigator: SYT11 (2 documents)

    Export disorders for SYT11 gene to outside databases

    Publications
    for SYT11 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SYT11 gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with SYT11)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The autosomal recessive juvenile Parkinson disease gene product, parkin, interacts with and ubiquitinates synaptotagmin XI. (PubMed id 12925569)1, 2, 9 Huynh D.P.... Pulst S.M. (2003)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Genomic analysis of synaptotagmin genes. (PubMed id 11543631)1, 3 Craxton M.A. (2001)
    5. Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 7584044)1, 2 Nomura N....Tabata S. (1994)
    6. Synaptotagmin XI as a candidate gene for susceptibility to schizophrenia. (PubMed id 17192956)1, 9 Inoue S....Oishi M. (2007)
    7. Screening for mutations in synaptotagmin XI in Parkinson's disease. (PubMed id 15354386)1, 9 Glass A.S....Riess O. (2004)
    8. Identification of novel ATP13A2 interactors and their role in a-synuclein misfolding and toxicity. (PubMed id 22645275)1 Usenovic M....Krainc D. (2012)
    9. Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide associat ion studies. (PubMed id 21292315)1  ....Wood N.W. (2011)
    10. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)

    External Searches for SYT11 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SYT11 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23208 HGNC: 19239 AceView: SYT11 Ensembl:ENSG00000132718 euGenes: HUgn23208
    ECgene: SYT11 H-InvDB: SYT11

    Other Databases showing SYT11 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA0080

    Specialized Databases showing SYT11 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SYT11 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SYT11 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SYT11 gene:
    Search GeneIP for patents involving SYT11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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