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SYT11 Gene

protein-coding   GIFtS: 61
GCID: GC01P155829

Synaptotagmin XI

Alzheimer's & Parkinson's Diseases Congress
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at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Synaptotagmin XI1 2 3     sytXI2
SYT122     KIAA00803
Synaptotagmin 122     SytXI3
synaptotagmin-112     

External Ids:    HGNC: 192391   Entrez Gene: 232082   Ensembl: ENSG000001327187   OMIM: 6087415   UniProtKB: Q9BT883   

Export aliases for SYT11 gene to outside databases

Previous GC identifers: GC01U990248 GC01P151576 GC01P152607 GC01P153046 GC01P152642 GC01P154095 GC01P127190


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SYT11 Gene:
This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that
are known calcium sensors and mediate calcium-dependent regulation of membrane trafficking in synaptic
transmission. The encoded protein is also a substrate for ubiquitin-E3-ligase parkin. The gene has previously
been referred to as synaptotagmin XII but has been renamed synaptotagmin XI to be consistent with mouse and rat
official nomenclature. (provided by RefSeq, Apr 2010)

GeneCards Summary for SYT11 Gene:
SYT11 (synaptotagmin XI) is a protein-coding gene. Diseases associated with SYT11 include autosomal recessive juvenile parkinson disease, and parkinson's disease. GO annotations related to this gene include transporter activity. An important paralog of this gene is SYT15.

UniProtKB/Swiss-Prot: SYT11_HUMAN, Q9BT88
Function: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid
binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis
(By similarity)

Gene Wiki entry for SYT11 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SYT11 gene promoter:
         RFX1   Pax-5   AP-4   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   YY1   POU2F1   POU2F1a   c-Myb   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSYT11 promoter sequence
   Search Chromatin IP Primers for SYT11

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SYT11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.2   Ensembl cytogenetic band:  1q22   HGNC cytogenetic band: 1q22

SYT11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SYT11 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P155829:  view genomic region     (about GC identifiers)

Start:
155,829,260 bp from pter      End:
155,854,990 bp from pter
Size:
25,731 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SYT11_HUMAN, Q9BT88 (See protein sequence)
Recommended Name: Synaptotagmin-11  
Size: 431 amino acids; 48297 Da
Cofactor: Binds 3 calcium ions per subunit. The ions are bound to the C2 domains (By similarity)
Subunit: Homodimer. Can also form heterodimers (By similarity). Interacts with PARK2
Sequence caution: Sequence=BAA07527.2; Type=Erroneous initiation;
Secondary accessions: Q14998 Q5W0D4 Q68CT5 Q8IXU3 Q96SU2

Explore the universe of human proteins at neXtProt for SYT11: NX_Q9BT88

Explore proteomics data for SYT11 at MOPED

Post-translational modifications: 

  • Ubiquitinated and targeted to the proteasome complex for degradation1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SYT11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_689493.3  
    ENSEMBL proteins: 
     ENSP00000357307   ENSP00000441657  

    SYT11 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for SYT11
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    Novus Biologicals SYT11 Protein
    Novus Biologicals SYT11 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SYT11

    SYT11 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    LSBio Antibodies in human, mouse, rat for SYT11

    SYT11 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SYT11
    Cloud-Clone Corp. CLIAs for SYT11


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SYT: Synaptotagmins

    3 InterPro protein domains:
     IPR028699 SYT11
     IPR001565 Synaptotagmin
     IPR000008 C2_dom

    Graphical View of Domain Structure for InterPro Entry Q9BT88

    ProtoNet protein and cluster: Q9BT88

    1 Blocks protein domain: IPB000008 C2 domain

    UniProtKB/Swiss-Prot: SYT11_HUMAN, Q9BT88
    Similarity: Belongs to the synaptotagmin family
    Similarity: Contains 2 C2 domains


    SYT11 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SYT11_HUMAN, Q9BT88
    Function: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid
    binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis
    (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity IEA--
    GO:0005515protein binding IPI16189514
    GO:0046872metal ion binding IEA--
         
    SYT11 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for SYT11:
     Elongated cells  Synthetic lethal with imatinib 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Syt11):
     normal 

    SYT11 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SYT11
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SYT11

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SYT11
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SYT11

    miRNA
    Products:
        
    miRTarBase miRNAs that target SYT11:
    hsa-mir-16-5p (MIRT051123), hsa-mir-10b-5p (MIRT047413)

    Block miRNA regulation of human, mouse, rat SYT11 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SYT11 (see all 107):
    hsa-miR-579 hsa-miR-1321 hsa-miR-642a hsa-miR-300 hsa-miR-134 hsa-miR-371-5p hsa-miR-3916 hsa-miR-525-3p
    SwitchGear 3'UTR luciferase reporter plasmidSYT11 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SYT11
    Predesigned siRNA for gene silencing in human, mouse, rat SYT11

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SYT11

    Clone
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    OriGene clones in human, mouse for SYT11 (see all 7)
    OriGene ORF clones in mouse, rat for SYT11
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SYT11 (NM_152280)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SYT11
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYT11

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for SYT11 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYT11


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SYT11_HUMAN, Q9BT88: Membrane; Single-pass membrane protein. Cell junction, synapse (By similarity). Cytoplasmic
    vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein (By similarity). Note=In
    substantia nigra, observed in neuronal cell bodies and neurites. Found in the core of the Lewy bodies in the
    brain of sporadic Parkinson disease patients
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    plasma membrane2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral component of plasma membrane IEA--
    GO:0008021synaptic vesicle ----
    GO:0030054cell junction IEA--
    GO:0030672synaptic vesicle membrane IEA--

    SYT11 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SYT11 About    
    See pathways by source

    SuperPathContained pathways About
    1CDK-mediated phosphorylation and removal of Cdc6
    Parkinson's Disease Pathway0.31
    2Parkinsons Disease Pathway
    Parkinsons Disease Pathway

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for SYT11
        Parkinson's Disease Pathway

    1 BioSystems Pathway for SYT11
        Parkinsons Disease Pathway


        Pathway & Disease-focused RT2 Profiler PCR Array including SYT11: 
              Parkinson's Disease in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SYT11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    Selected Interacting proteins for SYT11 (Q9BT881, 2, 3 ENSP000003573074) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APPBP2Q926241, 2, 3, ENSP000000831824EBI-751770,EBI-743771 MINT-68271 I2D: score=5 STRING: ENSP00000083182
    CSNK1A1P487292, 3, ENSP000002617984MINT-17245 I2D: score=1 STRING: ENSP00000261798
    PARK2O602603, ENSP000003558654I2D: score=2 STRING: ENSP00000355865
    SYNCRIPO605063, ENSP000003586354I2D: score=2 STRING: ENSP00000358635
    MEOX2P502223I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SYT11

    1 HMDB Compound for SYT11    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    1 Novoseek inferred chemical compound relationship for SYT11 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcium 8.92 2 17192956 (1)



    SYT11 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SYT11 gene: 
    NM_152280.4  

    Unigene Cluster for SYT11:

    Synaptotagmin XI
    Hs.32984  [show with all ESTs]
    Unigene Representative Sequence: NM_152280
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368324(uc001fmg.3 uc010pgq.2) ENST00000539162

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SYT11 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SYT11 (see all 107):
    hsa-miR-579 hsa-miR-1321 hsa-miR-642a hsa-miR-300 hsa-miR-134 hsa-miR-371-5p hsa-miR-3916 hsa-miR-525-3p
    SwitchGear 3'UTR luciferase reporter plasmidSYT11 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SYT11
    Predesigned siRNA for gene silencing in human, mouse, rat SYT11
    Clone
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    OriGene clones in human, mouse for SYT11 (see all 7)
    OriGene ORF clones in mouse, rat for SYT11
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SYT11 (NM_152280)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SYT11
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYT11
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SYT11
    OriGene qSTAR qPCR primer pairs in human, mouse for SYT11
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SYT11
      QuantiTect SYBR Green Assays in human, mouse, rat SYT11
      QuantiFast Probe-based Assays in human, mouse, rat SYT11

    Additional mRNA sequence: 

    AK021924.1 AK026178.1 AK027540.1 AK074931.1 AK296378.1 BC004291.1 BC013690.1 BC039205.1 
    CR749792.1 

    18 DOTS entries:

    DT.453243  DT.95271113  DT.100885367  DT.91956546  DT.121381478  DT.95271111  DT.121381286  DT.101977430 
    DT.100775452  DT.100833393  DT.121381426  DT.107869  DT.100885352  DT.121381162  DT.121381274  DT.121381160 
    DT.91765021  DT.95085591 

    Selected AceView cDNA sequences (see all 283):

    AA446147 AI700596 AI014332 BE465024 BQ893416 AI784243 AA421194 F02554 
    AA429657 AI014322 F02124 BX507909 N32969 AW452169 AI423001 AA416537 
    BI752080 BM836331 BQ884027 F09117 F03447 Z45864 AI003496 AA909981 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for SYT11    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b
    SP1:                                -               
    SP2:                                                
    SP3:                                -               


    ECgene alternative splicing isoforms for SYT11

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SYT11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATTGTGTGA
    SYT11 Expression
    About this image


    SYT11 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Brain (Nervous System)    fully expand to see all 12 entries
             Thalamus
             Oligodendrocyte progenitor cells
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Telencephalon
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Mature Horizontal Cells Inner Nuclear Layer
             Lens
     
     NULL (Uncategorized)
             Neural rosettes
     
     Bone (Muscoskeletal System)
             Zeugopod Epiphyseal End
    SYT11 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SYT11 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.32984
        Pathway & Disease-focused RT2 Profiler PCR Array including SYT11: 
              Parkinson's Disease in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for SYT11
    OriGene qSTAR qPCR primer pairs in human, mouse for SYT11
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SYT11
    QuantiTect SYBR Green Assays in human, mouse, rat SYT11
    QuantiFast Probe-based Assays in human, mouse, rat SYT11
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYT11

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SYT11 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Syt111 , 5 synaptotagmin XI1, 5 90(n)1
    95.35(a)1
      3 (38.96 cM)5
    2295211  NM_018804.31  NP_061274.21 
     887447005 
    chicken
    (Gallus gallus)
    Aves SYT111 synaptotagmin XI 78.63(n)
    88.34(a)
      429166  XM_426721.4  XP_426721.3 
    lizard
    (Anolis carolinensis)
    Reptilia SYT116
    synaptotagmin XI
    87(a)
    1 ↔ 1
    GL343519.1(440899-446199)
    zebrafish
    (Danio rerio)
    Actinopterygii BC044424.12   -- 81.24(n)    BC044424.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Syt46
    Synaptotagmin 4
    36(a)
    1 → many
    3R(3091783-3096531)
    worm
    (Caenorhabditis elegans)
    Secernentea snt-46
    Protein SNT-4 (snt-4) mRNA, complete cds
    32(a)
    1 → many
    I(6436098-6441191) WBGene00004924


    ENSEMBL Gene Tree for SYT11 (if available)
    TreeFam Gene Tree for SYT11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SYT11 gene
    SYT152  SYT42  SYT52  SYT92  SYT82  SYT102  SYT32  SYT62  
    SYT172  SYT122  SYT22  SYT72  SYT12  
    Selected SIMAP similar genes for SYT11 using alignment to 2 protein entries:     SYT11_HUMAN (see all proteins) (see all similar genes):
    SYT4    PRKCG    SYT5    SYT10    SYT2    SYT7
    SYT1    SYT9    PRKCB    SYT6    PRKCA    SYT8
    SYTL4    SYT17    DOC2A    PCLO    ESYT2    CHR11SYT

    SYT11 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SYT11 (see all 450)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1919819731,2
    --155829035(+) CTGTAC/TTAAAG 1 -- us2k10--------
    rs16258211,2
    C,H--155829140(-) AGGCCC/GCGCCC 1 -- us2k112Minor allele frequency- G:0.10NA WA CSA 257
    rs1849285521,2
    --155829153(+) TTCTCG/TGGAAA 1 -- us2k10--------
    rs1882621171,2
    --155829158(+) GGGAAA/CACTCG 1 -- us2k10--------
    rs1450311491,2
    C--155829228(+) AATCT-/TTCGGAAGAGGCGGA
    GTCTTCTTCCGAGGACCA
    TTCGG
    1 -- us2k10--------
    rs3767224131,2
    C--155829268(+) GAAGA-/AGGCGG 2 -- ut510--------
    rs1508035901,2
    C--155829356(+) TTAGCG/TCAGCG 1 -- ut510--------
    rs17494121,2
    C,F,H--155829360(-) GATGCT/GCTGAG 1 -- ut51 ese320Minor allele frequency- G:0.15MN NS EA NA WA CSA 1416
    rs168370681,2
    C,F,H--155829478(+) GCTGCC/GTCGGT 1 -- ut51 ese310Minor allele frequency- G:0.15NA NS EA WA 756
    rs38205941,2
    C,F,A,H--155829511(+) TGTCTT/CACCAT 1 -- ut51 ese330Minor allele frequency- C:0.50EA NA MN NS WA EU 6809

    HapMap Linkage Disequilibrium report for SYT11 (155829260 - 155854990 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SYT11:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2664479CNV Deletion23128226
    esv33869CNV Loss17666407

    Human Gene Mutation Database (HGMD): SYT11
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SYT11
    DNA2.0 Custom Variant and Variant Library Synthesis for SYT11

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608741    OMIM disorders: --

    7 diseases for SYT11:    
    About MalaCards
    autosomal recessive juvenile parkinson disease    parkinson's disease    labyrinthitis    schizophrenia
    malaria    cerebritis    neuronitis


    SYT11 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    1 Novoseek inferred disease relationship for SYT11 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    schizophrenia 31 5 17192956 (4), 15777718 (1)

    Genetic Association Database (GAD): SYT11
    Human Genome Epidemiology (HuGE) Navigator: SYT11 (2 documents)

    Export disorders for SYT11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SYT11 gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with SYT11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The autosomal recessive juvenile Parkinson disease gene product, parkin, interacts with and ubiquitinates synaptotagmin XI. (PubMed id 12925569)1, 2, 9 Huynh D.P.... Pulst S.M. (Hum. Mol. Genet. 2003)
    2. Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies. (PubMed id 21292315)1, 4  ....Wood N.W. (Lancet 2011)
    3. Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. (PubMed id 19156168)1, 4 Need A.C....Goldstein D.B. (Eur. J. Hum. Genet. 2009)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Genomic analysis of synaptotagmin genes. (PubMed id 11543631)1, 3 Craxton M.A. (Genomics 2001)
    7. Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 7584044)1, 2 Nomura N.... Tabata S. (DNA Res. 1994)
    8. Synaptotagmin XI as a candidate gene for susceptibility to schizophrenia. (PubMed id 17192956)1, 9 Inoue S....Oishi M. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2007)
    9. Screening for mutations in synaptotagmin XI in Parkinson's disease. (PubMed id 15354386)1, 9 Glass A.S....Riess O. (J. Neural Transm. Suppl. 2004)
    10. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23208 HGNC: 19239 AceView: SYT11 Ensembl:ENSG00000132718 euGenes: HUgn23208
    ECgene: SYT11 H-InvDB: SYT11

    (According to HUGE)
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    HUGE: KIAA0080

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SYT11 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SYT11 gene:
    Search GeneIP for patents involving SYT11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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