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Aliases for SYT11 Gene

Aliases for SYT11 Gene

  • Synaptotagmin 11 2 3 5
  • Synaptotagmin XI 2 3 4
  • SytXI 3 4
  • Synaptotagmin 12 3
  • Synaptotagmin-11 3
  • KIAA0080 4
  • SYT12 3

External Ids for SYT11 Gene

Previous GeneCards Identifiers for SYT11 Gene

  • GC01U990248
  • GC01P151576
  • GC01P152607
  • GC01P153046
  • GC01P152642
  • GC01P154095
  • GC01P127190

Summaries for SYT11 Gene

Entrez Gene Summary for SYT11 Gene

  • This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that are known calcium sensors and mediate calcium-dependent regulation of membrane trafficking in synaptic transmission. The encoded protein is also a substrate for ubiquitin-E3-ligase parkin. The gene has previously been referred to as synaptotagmin XII but has been renamed synaptotagmin XI to be consistent with mouse and rat official nomenclature. [provided by RefSeq, Apr 2010]

GeneCards Summary for SYT11 Gene

SYT11 (Synaptotagmin 11) is a Protein Coding gene. Among its related pathways are Vesicle-mediated transport and Parkinsons Disease Pathway. GO annotations related to this gene include calcium ion binding and syntaxin binding. An important paralog of this gene is SYT4.

UniProtKB/Swiss-Prot for SYT11 Gene

  • May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis.

Gene Wiki entry for SYT11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYT11 Gene

Genomics for SYT11 Gene

Regulatory Elements for SYT11 Gene

Enhancers for SYT11 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F156079 1.4 Ensembl ENCODE 5.3 +224.3 224304 7.9 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 PEAR1 KRTCAP2 MSTO2P THBS3 SYT11 RIT1 LMNA GC01M156123
GH01F155763 0.7 Ensembl ENCODE 10.5 -95.8 -95773 1.2 GATA3 JUN SYT11 GON4L DAP3 PIR32612 LOC100132108
GH01F155833 1.2 Ensembl ENCODE 5.1 -25.3 -25252 1.6 TBP HDAC1 ATF1 PKNOX1 CBX3 ARNT NFRKB SIN3A NFXL1 BMI1 DAP3 SYT11 LOC100132108 PIR32612
GH01F155744 1.1 ENCODE 5.1 -114.0 -113988 1.5 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF143 ZNF207 SP3 YY1AP1 KIAA0907 SYT11 MSTO2P ENSG00000227673
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SYT11 on UCSC Golden Path with GeneCards custom track

Promoters for SYT11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001750446 331 2401 PKNOX1 WRNIP1 YBX1 FEZF1 ZNF2 YY1 SLC30A9 ZNF263 SP3 JUNB

Genomic Location for SYT11 Gene

155,859,469 bp from pter
155,885,199 bp from pter
25,731 bases
Plus strand

Genomic View for SYT11 Gene

Genes around SYT11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SYT11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SYT11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYT11 Gene

Proteins for SYT11 Gene

  • Protein details for SYT11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q14998
    • Q5W0D4
    • Q68CT5
    • Q8IXU3
    • Q96SU2

    Protein attributes for SYT11 Gene

    431 amino acids
    Molecular mass:
    48297 Da
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    • Homodimer. Can also form heterodimers (By similarity). Interacts with PARK2.
    • Sequence=BAA07527.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SYT11 Gene

Post-translational modifications for SYT11 Gene

  • Ubiquitinated and targeted to the proteasome complex for degradation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SYT11 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SYT11 Gene

Domains & Families for SYT11 Gene

Gene Families for SYT11 Gene

Protein Domains for SYT11 Gene


Suggested Antigen Peptide Sequences for SYT11 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 C2 domains.
  • Belongs to the synaptotagmin family.
  • Contains 2 C2 domains.
  • Belongs to the synaptotagmin family.
genes like me logo Genes that share domains with SYT11: view

Function for SYT11 Gene

Molecular function for SYT11 Gene

UniProtKB/Swiss-Prot Function:
May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis.

Gene Ontology (GO) - Molecular Function for SYT11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 NOT calcium ion binding ISS,IBA --
GO:0005515 protein binding IPI 16189514
GO:0005544 NOT calcium-dependent phospholipid binding ISS,IBA --
GO:0019905 syntaxin binding IBA --
GO:0030276 clathrin binding IBA --
genes like me logo Genes that share ontologies with SYT11: view
genes like me logo Genes that share phenotypes with SYT11: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SYT11 Gene

Localization for SYT11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYT11 Gene

Membrane; Single-pass membrane protein. Cell junction, synapse. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein. Note=In substantia nigra, observed in neuronal cell bodies and neurites. Found in the core of the Lewy bodies in the brain of sporadic Parkinson disease patients.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SYT11 gene
Compartment Confidence
plasma membrane 3
cytosol 3
lysosome 3
endosome 2

Gene Ontology (GO) - Cellular Components for SYT11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001891 phagocytic cup IEA --
GO:0005737 cytoplasm IEA --
GO:0005764 lysosome IEA --
GO:0005886 plasma membrane IBA --
GO:0005887 integral component of plasma membrane IEA --
genes like me logo Genes that share ontologies with SYT11: view

Pathways & Interactions for SYT11 Gene

genes like me logo Genes that share pathways with SYT11: view

Pathways by source for SYT11 Gene

Gene Ontology (GO) - Biological Process for SYT11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001778 plasma membrane repair IEA,ISS --
GO:0006906 vesicle fusion IBA --
GO:0009611 response to wounding IEA --
GO:0017158 NOT regulation of calcium ion-dependent exocytosis IBA --
GO:0046929 negative regulation of neurotransmitter secretion TAS 21563316
genes like me logo Genes that share ontologies with SYT11: view

No data available for SIGNOR curated interactions for SYT11 Gene

Drugs & Compounds for SYT11 Gene

(1) Drugs for SYT11 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with SYT11: view

Transcripts for SYT11 Gene

mRNA/cDNA for SYT11 Gene

Unigene Clusters for SYT11 Gene

Synaptotagmin XI:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SYT11 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b
SP1: -
SP3: -

Relevant External Links for SYT11 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SYT11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SYT11 Gene

mRNA differential expression in normal tissues according to GTEx for SYT11 Gene

This gene is overexpressed in Brain - Cortex (x4.2) and Brain - Frontal Cortex (BA9) (x4.1).

Protein differential expression in normal tissues from HIPED for SYT11 Gene

This gene is overexpressed in Heart (36.2), Serum (20.1), and Frontal cortex (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SYT11 Gene

Protein tissue co-expression partners for SYT11 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SYT11 Gene:


SOURCE GeneReport for Unigene cluster for SYT11 Gene:

genes like me logo Genes that share expression patterns with SYT11: view

No data available for mRNA Expression by UniProt/SwissProt for SYT11 Gene

Orthologs for SYT11 Gene

This gene was present in the common ancestor of animals.

Orthologs for SYT11 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SYT11 34 35
  • 99.61 (n)
(Bos Taurus)
Mammalia SYT11 34 35
  • 93.81 (n)
(Monodelphis domestica)
Mammalia SYT11 35
  • 93 (a)
(Canis familiaris)
Mammalia SYT11 34 35
  • 91.01 (n)
(Rattus norvegicus)
Mammalia Syt11 34
  • 90.05 (n)
(Mus musculus)
Mammalia Syt11 34 16 35
  • 90 (n)
(Gallus gallus)
Aves SYT11 34 35
  • 78.63 (n)
(Anolis carolinensis)
Reptilia SYT11 35
  • 87 (a)
(Danio rerio)
Actinopterygii syt11a 34 35
  • 65.89 (n)
syt11b 35
  • 58 (a)
fruit fly
(Drosophila melanogaster)
Insecta Syt4 35
  • 36 (a)
(Caenorhabditis elegans)
Secernentea snt-4 35
  • 32 (a)
Species where no ortholog for SYT11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SYT11 Gene

Gene Tree for SYT11 (if available)
Gene Tree for SYT11 (if available)

Paralogs for SYT11 Gene

Paralogs for SYT11 Gene

(19) SIMAP similar genes for SYT11 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SYT11: view

Variants for SYT11 Gene

Sequence variations from dbSNP and Humsavar for SYT11 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1049295 -- 155,885,156(+) AATGC(A/C)CCACA utr-variant-3-prime
rs1049300 -- 155,885,177(+) ATAAA(G/T)ACTGA utr-variant-3-prime
rs10531680 -- 155,866,990(+) CACAC(-/ACAT)ATATA intron-variant
rs1094558 -- 155,877,718(+) ccggc(G/T)aattt intron-variant
rs1094559 -- 155,877,819(+) ccaaa(A/G)tgcta intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SYT11 Gene

Variant ID Type Subtype PubMed ID
esv2664479 CNV deletion 23128226
esv2849680 CNV deletion 24192839
esv33869 CNV loss 17666407
esv3541067 CNV deletion 23714750
nsv1003170 CNV gain 25217958
nsv957176 CNV deletion 24416366

Variation tolerance for SYT11 Gene

Residual Variation Intolerance Score: 21% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.84; 17.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SYT11 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SYT11 Gene

Disorders for SYT11 Gene

Relevant External Links for SYT11

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SYT11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SYT11 Gene

Publications for SYT11 Gene

  1. The autosomal recessive juvenile Parkinson disease gene product, parkin, interacts with and ubiquitinates synaptotagmin XI. (PMID: 12925569) Huynh D.P. … Pulst S.M. (Hum. Mol. Genet. 2003) 3 4 22 64
  2. Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies. (PMID: 21292315) . … Wood N.W. (Lancet 2011) 3 46 64
  3. Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. (PMID: 19156168) Need A.C. … Goldstein D.B. (Eur. J. Hum. Genet. 2009) 3 46 64
  4. Synaptotagmin XI as a candidate gene for susceptibility to schizophrenia. (PMID: 17192956) Inoue S. … Oishi M. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2007) 3 22 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for SYT11 Gene

Sources for SYT11 Gene

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