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Aliases for SYT10 Gene

Aliases for SYT10 Gene

  • Synaptotagmin X 2 3 4
  • SytX 3 4
  • Synaptotagmin 10 3
  • Synaptotagmin-10 3

External Ids for SYT10 Gene

Previous GeneCards Identifiers for SYT10 Gene

  • GC00U906274
  • GC12M033421
  • GC12M033419
  • GC12M033528
  • GC12M033268

Summaries for SYT10 Gene

GeneCards Summary for SYT10 Gene

SYT10 (Synaptotagmin X) is a Protein Coding gene. GO annotations related to this gene include protein homodimerization activity and transporter activity. An important paralog of this gene is SYT5.

UniProtKB/Swiss-Prot for SYT10 Gene

  • May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYT10 Gene

Genomics for SYT10 Gene

Regulatory Elements for SYT10 Gene

Genomic Location for SYT10 Gene

Start:
33,374,238 bp from pter
End:
33,439,819 bp from pter
Size:
65,582 bases
Orientation:
Minus strand

Genomic View for SYT10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SYT10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYT10 Gene

Proteins for SYT10 Gene

  • Protein details for SYT10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6XYQ8-SYT10_HUMAN
    Recommended name:
    Synaptotagmin-10
    Protein Accession:
    Q6XYQ8
    Secondary Accessions:
    • Q495U2

    Protein attributes for SYT10 Gene

    Size:
    523 amino acids
    Molecular mass:
    59127 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.;
    Quaternary structure:
    • Homodimer. Can also form heterodimers with SYT6 (By similarity).

neXtProt entry for SYT10 Gene

Proteomics data for SYT10 Gene at MOPED

Post-translational modifications for SYT10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SYT10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SYT10 Gene

Domains for SYT10 Gene

Gene Families for SYT10 Gene

HGNC:
  • SYT :Synaptotagmins

Protein Domains for SYT10 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SYT10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6XYQ8

UniProtKB/Swiss-Prot:

SYT10_HUMAN :
  • Q6XYQ8
Domain:
  • Contains 2 C2 domains.
Family:
  • Belongs to the synaptotagmin family.
genes like me logo Genes that share domains with SYT10: view

Function for SYT10 Gene

Molecular function for SYT10 Gene

UniProtKB/Swiss-Prot Function: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis.

Gene Ontology (GO) - Molecular Function for SYT10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity --
GO:0005509 calcium ion binding IBA --
GO:0005515 protein binding --
GO:0005544 calcium-dependent phospholipid binding IBA --
GO:0019905 syntaxin binding IBA --
genes like me logo Genes that share ontologies with SYT10: view

Phenotypes for SYT10 Gene

MGI mutant phenotypes for SYT10:
inferred from 2 alleles
GenomeRNAi human phenotypes for SYT10:
genes like me logo Genes that share phenotypes with SYT10: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SYT10 Gene

Localization for SYT10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYT10 Gene

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SYT10 Gene COMPARTMENTS Subcellular localization image for SYT10 gene
Compartment Confidence
cytosol 3
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SYT10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA --
GO:0008021 synaptic vesicle --
GO:0016021 integral component of membrane IEA --
GO:0030054 cell junction IEA --
GO:0030672 synaptic vesicle membrane IEA --
genes like me logo Genes that share ontologies with SYT10: view

Pathways for SYT10 Gene

SuperPathways for SYT10 Gene

No Data Available

Interacting Proteins for SYT10 Gene

Gene Ontology (GO) - Biological Process for SYT10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport --
GO:0006906 vesicle fusion IBA --
GO:0016079 synaptic vesicle exocytosis IBA --
GO:0017158 regulation of calcium ion-dependent exocytosis IBA --
GO:0048791 calcium ion-dependent exocytosis of neurotransmitter IBA --
genes like me logo Genes that share ontologies with SYT10: view

No data available for Pathways by source for SYT10 Gene

Compounds for SYT10 Gene

(1) HMDB Compounds for SYT10 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
genes like me logo Genes that share compounds with SYT10: view

Transcripts for SYT10 Gene

mRNA/cDNA for SYT10 Gene

(3) Additional mRNA sequences :
(3) REFSEQ mRNAs :
(5) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SYT10 Gene

Synaptotagmin X:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SYT10 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP1:
SP2: - -

Relevant External Links for SYT10 Gene

GeneLoc Exon Structure for
SYT10
ECgene alternative splicing isoforms for
SYT10

Expression for SYT10 Gene

mRNA expression in normal human tissues for SYT10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SYT10 Gene

This gene is overexpressed in Nerve - Tibial (8.0), Pituitary (4.2), and Colon - Sigmoid (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SYT10 Gene

SOURCE GeneReport for Unigene cluster for SYT10 Gene Hs.118703

mRNA Expression by UniProt/SwissProt for SYT10 Gene

Q6XYQ8-SYT10_HUMAN
Tissue specificity: Expressed only in pancreas, lung and kidney.
genes like me logo Genes that share expressions with SYT10: view

Orthologs for SYT10 Gene

This gene was present in the common ancestor of animals.

Orthologs for SYT10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SYT10 35
  • 99.11 (n)
  • 99.43 (a)
SYT10 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SYT10 35
  • 91.33 (n)
  • 93.5 (a)
SYT10 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SYT10 35
  • 93.3 (n)
  • 96.93 (a)
SYT10 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Syt10 35
  • 87.19 (n)
  • 92.93 (a)
Syt10 16
Syt10 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SYT10 36
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Syt10 35
  • 87.19 (n)
  • 93.31 (a)
chicken
(Gallus gallus)
Aves SYT10 35
  • 81.55 (n)
  • 88.51 (a)
SYT10 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SYT10 36
  • 86 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii syt10 35
  • 67.88 (n)
  • 75.38 (a)
syt10 36
  • 65 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Syt1 36
  • 34 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea snt-1 36
  • 35 (a)
ManyToMany
snt-2 36
  • 35 (a)
ManyToMany
snt-3 36
  • 45 (a)
ManyToMany
Species with no ortholog for SYT10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SYT10 Gene

ENSEMBL:
Gene Tree for SYT10 (if available)
TreeFam:
Gene Tree for SYT10 (if available)

Paralogs for SYT10 Gene

Paralogs for SYT10 Gene

Selected SIMAP similar genes for SYT10 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SYT10: view

Variants for SYT10 Gene

Sequence variations from dbSNP and Humsavar for SYT10 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1343676 -- 33,384,452(+) CTGTT(C/T)ACTAC intron-variant
rs1482989 -- 33,431,819(+) AATGG(A/G)TGGTG intron-variant
rs1482990 -- 33,436,508(+) GTCTT(C/G)ACCAA intron-variant
rs1482991 -- 33,437,625(+) ATTTA(C/T)AGCAT intron-variant
rs1482993 -- 33,441,580(-) TTTAC(C/T)TAATG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SYT10 Gene

Variant ID Type Subtype PubMed ID
nsv832368 CNV Gain 17160897
dgv496e1 CNV Complex 17122850
esv34883 CNV Gain 17911159
nsv469348 CNV Gain 19166990
nsv818908 CNV Gain 17921354
nsv820253 CNV Loss 19587683
essv5432 CNV CNV 17122850

Relevant External Links for SYT10 Gene

HapMap Linkage Disequilibrium report
SYT10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SYT10 Gene

Disorders for SYT10 Gene

No disorders were found for SYT10 Gene.

No data available for UniProtKB/Swiss-Prot for SYT10 Gene

Publications for SYT10 Gene

  1. Cloning and characterization of human synaptotagmin 10 gene. (PMID: 14756426) Zhao E. … Mao Y. (DNA Seq. 2003) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. (PMID: 23583979) den Hoed M. … Loos R.J. (Nat. Genet. 2013) 3
  4. Conserved N-terminal cysteine motif is essential for homo- and heterodimer formation of synaptotagmins III, V, VI, and X. (PMID: 10531343) Fukuda M. … Mikoshiba K. (J. Biol. Chem. 1999) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for SYT10 Gene

Sources for SYT10 Gene

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