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Aliases for SYT10 Gene

Aliases for SYT10 Gene

  • Synaptotagmin 10 2 3 5
  • Synaptotagmin X 2 3 4
  • SytX 3 4

External Ids for SYT10 Gene

Previous GeneCards Identifiers for SYT10 Gene

  • GC00U906274
  • GC12M033421
  • GC12M033419
  • GC12M033528
  • GC12M033268

Summaries for SYT10 Gene

GeneCards Summary for SYT10 Gene

SYT10 (Synaptotagmin 10) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding and identical protein binding. An important paralog of this gene is SYT5.

UniProtKB/Swiss-Prot for SYT10 Gene

  • Ca(2+) sensor specifically required for the Ca(2+)-dependent exocytosis of secretory vesicles containing IGF1 in neurons of the olfactory bulb. Exocytosis of IGF1 is required for sensory perception of smell. Not involved in Ca(2+)-dependent synaptic vesicle exocytosis (By similarity). Acts through Ca(2+) and phospholipid binding to the C2 domain: Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYT10 Gene

Genomics for SYT10 Gene

Regulatory Elements for SYT10 Gene

Promoters for SYT10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SYT10 on UCSC Golden Path with GeneCards custom track

Genomic Location for SYT10 Gene

Chromosome:
12
Start:
33,374,238 bp from pter
End:
33,439,819 bp from pter
Size:
65,582 bases
Orientation:
Minus strand

Genomic View for SYT10 Gene

Genes around SYT10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SYT10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SYT10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYT10 Gene

Proteins for SYT10 Gene

  • Protein details for SYT10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6XYQ8-SYT10_HUMAN
    Recommended name:
    Synaptotagmin-10
    Protein Accession:
    Q6XYQ8
    Secondary Accessions:
    • Q495U2

    Protein attributes for SYT10 Gene

    Size:
    523 amino acids
    Molecular mass:
    59127 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    • Homodimer; disulfide-linked via the cysteine motif. Can also form heterodimers with SYT3, SYT6, SYT7 and SYT9.

neXtProt entry for SYT10 Gene

Proteomics data for SYT10 Gene at MOPED

Post-translational modifications for SYT10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SYT10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SYT10 Gene

Domains & Families for SYT10 Gene

Gene Families for SYT10 Gene

Protein Domains for SYT10 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SYT10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6XYQ8

UniProtKB/Swiss-Prot:

SYT10_HUMAN :
  • The cysteine motif mediates homo- or heterodimer formation via formation of disulfide bonds.
  • Belongs to the synaptotagmin family.
Domain:
  • The cysteine motif mediates homo- or heterodimer formation via formation of disulfide bonds.
  • The first C2 domain mediates Ca(2+)-dependent phospholipid binding.
  • Contains 2 C2 domains.
Family:
  • Belongs to the synaptotagmin family.
genes like me logo Genes that share domains with SYT10: view

Function for SYT10 Gene

Molecular function for SYT10 Gene

UniProtKB/Swiss-Prot Function:
Ca(2+) sensor specifically required for the Ca(2+)-dependent exocytosis of secretory vesicles containing IGF1 in neurons of the olfactory bulb. Exocytosis of IGF1 is required for sensory perception of smell. Not involved in Ca(2+)-dependent synaptic vesicle exocytosis (By similarity). Acts through Ca(2+) and phospholipid binding to the C2 domain: Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (By similarity).

Gene Ontology (GO) - Molecular Function for SYT10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005544 calcium-dependent phospholipid binding IBA --
GO:0030276 clathrin binding IBA --
GO:0042803 protein homodimerization activity IEA --
genes like me logo Genes that share ontologies with SYT10: view
genes like me logo Genes that share phenotypes with SYT10: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SYT10 Gene

Localization for SYT10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYT10 Gene

Cytoplasmic vesicle, secretory vesicle membrane; Single-pass membrane protein. Note=Localizes to neuronal vesicles containing IGF1 that are not enriched at synapses. Does not colocalize with synaptic vesicles or with the Golgi apparatus. {ECO:0000250 UniProtKB:Q9R0N4}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SYT10 Gene COMPARTMENTS Subcellular localization image for SYT10 gene
Compartment Confidence
cytosol 3
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SYT10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030658 transport vesicle membrane IEA --
GO:0030672 synaptic vesicle membrane IEA --
genes like me logo Genes that share ontologies with SYT10: view

Pathways & Interactions for SYT10 Gene

SuperPathways for SYT10 Gene

No Data Available

Interacting Proteins for SYT10 Gene

Gene Ontology (GO) - Biological Process for SYT10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007608 sensory perception of smell ISS --
GO:0048791 calcium ion-regulated exocytosis of neurotransmitter IBA --
genes like me logo Genes that share ontologies with SYT10: view

No data available for Pathways by source and SIGNOR curated interactions for SYT10 Gene

Drugs & Compounds for SYT10 Gene

(1) Drugs for SYT10 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with SYT10: view

Transcripts for SYT10 Gene

mRNA/cDNA for SYT10 Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SYT10 Gene

Synaptotagmin X:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SYT10 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP1:
SP2: - -

Relevant External Links for SYT10 Gene

GeneLoc Exon Structure for
SYT10
ECgene alternative splicing isoforms for
SYT10

Expression for SYT10 Gene

mRNA expression in normal human tissues for SYT10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SYT10 Gene

This gene is overexpressed in Nerve - Tibial (x8.0), Pituitary (x4.2), and Colon - Sigmoid (x4.1).

Protein differential expression in normal tissues from HIPED for SYT10 Gene

This gene is overexpressed in Pancreatic juice (67.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SYT10 Gene



SOURCE GeneReport for Unigene cluster for SYT10 Gene Hs.118703

mRNA Expression by UniProt/SwissProt for SYT10 Gene

Q6XYQ8-SYT10_HUMAN
Tissue specificity: Expressed only in pancreas, lung and kidney.
genes like me logo Genes that share expression patterns with SYT10: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for SYT10 Gene

Orthologs for SYT10 Gene

This gene was present in the common ancestor of animals.

Orthologs for SYT10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SYT10 36
  • 99 (a)
OneToOne
SYT10 35
  • 99.11 (n)
  • 99.43 (a)
cow
(Bos Taurus)
Mammalia SYT10 36
  • 93 (a)
OneToOne
SYT10 35
  • 91.33 (n)
  • 93.5 (a)
dog
(Canis familiaris)
Mammalia SYT10 35
  • 93.3 (n)
  • 96.93 (a)
SYT10 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Syt10 16
Syt10 35
  • 87.19 (n)
  • 92.93 (a)
Syt10 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SYT10 36
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Syt10 35
  • 87.19 (n)
  • 93.31 (a)
chicken
(Gallus gallus)
Aves SYT10 35
  • 81.55 (n)
  • 88.51 (a)
SYT10 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SYT10 36
  • 86 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii syt10 36
  • 65 (a)
OneToOne
syt10 35
  • 67.88 (n)
  • 75.38 (a)
fruit fly
(Drosophila melanogaster)
Insecta Syt1 36
  • 34 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea snt-1 36
  • 35 (a)
ManyToMany
snt-2 36
  • 35 (a)
ManyToMany
snt-3 36
  • 45 (a)
ManyToMany
Species with no ortholog for SYT10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SYT10 Gene

ENSEMBL:
Gene Tree for SYT10 (if available)
TreeFam:
Gene Tree for SYT10 (if available)

Paralogs for SYT10 Gene

Paralogs for SYT10 Gene

(18) SIMAP similar genes for SYT10 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SYT10: view

Variants for SYT10 Gene

Sequence variations from dbSNP and Humsavar for SYT10 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs35190376 - 33,382,460(+) AACAA(A/C/G)TACAA reference, missense
rs34190017 - 33,379,869(-) CTATC(A/C/G)TCGAA reference, missense
rs34361405 - 33,376,888(-) CCGGG(C/T)GACCA reference, missense
rs12317722 - 33,407,351(+) AGGAA(A/C)TGTGG reference, missense, utr-variant-5-prime
rs1482993 -- 33,441,580(-) TTTAC(C/T)TAATG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SYT10 Gene

Variant ID Type Subtype PubMed ID
nsv832368 CNV Gain 17160897
dgv496e1 CNV Complex 17122850
esv34883 CNV Gain 17911159
nsv469348 CNV Gain 19166990
nsv818908 CNV Gain 17921354
nsv820253 CNV Loss 19587683
essv5432 CNV CNV 17122850

Variation tolerance for SYT10 Gene

Residual Variation Intolerance Score: 29% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.84; 48.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SYT10 Gene

HapMap Linkage Disequilibrium report
SYT10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SYT10 Gene

Disorders for SYT10 Gene

Relevant External Links for SYT10

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SYT10

No disorders were found for SYT10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SYT10 Gene

Publications for SYT10 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. (PMID: 23583979) den Hoed M. … Loos R.J. (Nat. Genet. 2013) 3
  4. Cloning and characterization of human synaptotagmin 10 gene. (PMID: 14756426) Zhao E. … Mao Y. (DNA Seq. 2003) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for SYT10 Gene

Sources for SYT10 Gene

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