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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SYT10 Gene

protein-coding GIFtS: 43
GCID: GC12M033528

synaptotagmin X

Search for SYT10
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Synaptotagmin X¹ ² ³
Synaptotagmin 10²
Synaptotagmin-10¹
SytX³
SytX³

External Ids:	HGNC: 19266¹	Entrez Gene: 341359²	Ensembl: ENSG00000110975⁷	UniProtKB: Q6XYQ8³

Export aliases for SYT10 gene to outside databases

Previous GC identifers: GC00U906274 GC12M033421 GC12M033419 GC12M033268

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: SYT10_HUMAN, Q6XYQ8

Function: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding

to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_009714.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SYT10 gene promoter:
SRF Pbx1a SRF (504 AA) p300 FOXD3 CUTL1 YY1 Evi-1 Max c-Myc
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SYT10 promoter sequence

Search SABiosciences Chromatin IP Primers for SYT10

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SYT10

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p11.1 Ensembl cytogenetic band: 12p11.1 HGNC cytogenetic band: 12p11

SYT10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SYT10 gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12M033528: view genomic region (about GC identifiers)

Start:	33,527,173 bp from pter	End:	33,592,754 bp from pter
Size:	65,582 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SYT10_HUMAN, Q6XYQ8 (See protein sequence)

Recommended Name: Synaptotagmin-10

Size: 523 amino acids; 59127 Da

Cofactor: Binds 3 calcium ions per subunit. The ions are bound to the C2 domains (By similarity)

Subunit: Homodimer. Can also form heterodimers with SYT6 (By similarity)

Subcellular location: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein

(By similarity)

Secondary accessions: Q495U2

Explore the universe of human proteins at neXtProt for SYT10: NX_Q6XYQ8

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q6XYQ8

SYT10 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_945343.1

ENSEMBL proteins:

ENSP00000228567 ENSP00000444577 ENSP00000438691

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Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008021	synaptic vesicle	--	--
GO:0016020	membrane	--	--
GO:0016021	integral to membrane	IEA	--
GO:0030054	cell junction	IEA	--
GO:0030672	synaptic vesicle membrane	IEA	--

SYT10 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SYT10 for domains About GeneDecksing

5 InterPro domains/families:

IPR008973 C2_Ca/lipid-bd_dom_CaLB

IPR001565 Synaptotagmin

IPR018029 C2_membr_targeting

IPR020477 C2_dom

IPR000008 C2_Ca-dep

Graphical View of Domain Structure for InterPro Entry Q6XYQ8

ProtoNet protein and cluster: Q6XYQ8

1 Blocks protein family: IPB000008 C2 domain

UniProtKB/Swiss-Prot: SYT10_HUMAN, Q6XYQ8

Similarity: Belongs to the synaptotagmin family

Similarity: Contains 2 C2 domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: SYT10_HUMAN, Q6XYQ8

Function: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding

to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis (By similarity)

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In Situ Assay
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Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005215	transporter activity	IEA	--
GO:0005515	protein binding	--	--
GO:0042802	identical protein binding	--	--
GO:0042803	protein homodimerization activity	IEA	--
GO:0046872	metal ion binding	IEA	--

SYT10 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for SYT10:

Decreased Wnt reporter activit

Animal Models:
2 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Syt10):

behavior/neurological

normal

SYT10 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SYT10

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006950	response to stress	IEA	--

SYT10 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

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Browse Tocris compounds for SYT10

1 HMDB Compound for SYT10 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--

Search CenterWatch for drugs/clinical trials and news about SYT10

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SYT10 gene:

NM_198992.3

Unigene Cluster for SYT10:

Synaptotagmin X

Hs.118703 [show with all ESTs]

Unigene Representative Sequence: AY198413

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000228567(uc001rll.1 uc009zju.1) ENST00000539102 ENST00000567656

ENST00000535526

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		hsa-miR-448 hsa-miR-15a hsa-miR-548v hsa-miR-301a hsa-miR-221 hsa-miR-3133 hsa-miR-650 hsa-miR-103a

		SwitchGear 3'UTR luciferase reporter plasmid: SYT10 3' UTR sequence

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Additional cDNA sequence:

AY198413.1 BC101024.2 BC101025.1

1 DOTS entry:

DT.101977138

5 AceView cDNA sequences:

BQ787948 BX479479 NM_198992 BQ777247 AY198413

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for SYT10 About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9
SP1:
SP2:					-		-

ECgene alternative splicing isoforms for SYT10

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SYT10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAAAAACTAT

About this image

SYT10 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Definitive endoderm-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SYT10 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.118703

UniProtKB/Swiss-Prot: SYT10_HUMAN, Q6XYQ8

Tissue specificity: Expressed only in pancreas, lung and kidney

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for SYT10 gene from 5/14 species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SYT10¹	synaptotagmin X	81.55(n) 88.51(a)		418129 XM_416361.3 XP_416361.2
lizard (Anolis carolinensis)	Reptilia	SYT10⁶	--	86(a)	1 ↔ 1	GL343678.1(171178-220180)
zebrafish (Danio rerio)	Actinopterygii	syt10¹	synaptotagmin X	68.59(n) 76.54(a)		564226 NM_001082842.1 NP_001076311.1
fruit fly (Drosophila melanogaster)	Insecta	Sytbeta⁶	Synaptotagmin beta	18(a)	possible ortholog	3L(15007795-15058077)
worm (Caenorhabditis elegans)	Secernentea	snt-6⁶	SyNapTotagmin family member (snt-6)	29(a)	possible ortholog	II(745469-750171)

ENSEMBL Gene Tree for SYT10 (if available)
TreeFam Gene Tree for SYT10 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SYT10 gene

SYT15² SYT4² SYT5² SYT8² SYT9² SYT3² SYT6² SYT17²

SYT11² SYT2² SYT12² SYT7² SYT1²

17 SIMAP similar genes for SYT10 using alignment to 4 protein entries: SYT10_HUMAN (see all proteins):

SYT6 SYT9 SYT2 SYT1 SYT3 SYT5

SYT7 SYT11 SYTL2 SYT4 DKFZp434D2429 SYT12

SYT15 CHR11SYT SYT17 SYT8 RPH3A

SYT10 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs112072044^1,2		--	33527899(+)	`TGTCAT/CTCTAT`	1	--	ds500¹		2		CSA WA	120
rs12309785^1,2	F,	--	33528143(+)	`GCAGAA/TCTGTG`	1	--	ds500¹		3		CSA WA	122
rs148212936^1,2		--	33528178(+)	`AAAATA/TTTTAC`	1	--	ds500¹		0	--	--	--	--
rs202091251^1,2	C	--	33528281(-)	`TTTTTG/TTAAAA`	1	--	ds500¹		0	--	--	--	--
rs141953546^1,2		--	33528296(+)	`AATTTC/TATAAC`	1	--	ds500¹		0	--	--	--	--
rs146134251^1,2		--	33528499(+)	`ACTTAA/GAAGAA`	1	--	ut3¹		0	--	--	--	--
rs185922615^1,2		--	33528560(+)	`ACCTTA/GATCCT`	1	--	ut3¹		0	--	--	--	--
rs189139302^1,2		--	33528602(+)	`GGAGGC/TCTGGG`	1	--	ut3¹		0	--	--	--	--
rs140119098^1,2		--	33528772(+)	`TGTGTA/GCAATC`	1	--	ut3¹		0	--	--	--	--
rs181080302^1,2		--	33528884(+)	`ATACAC/TGTCAC`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SYT10 (33527173 - 33592754 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for SYT10
4 CNVs: 9691 2978 8723 3885
1 Indel: 58565

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SYT10 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SYT10)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Cloning and characterization of human synaptotagmin 10 gene. (PubMed id 14756426)^{1, 2} Zhao E.... Mao Y. (2003)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Conserved N-terminal cysteine motif is essential for homo- and heterodimer formation of synaptotagmins III, V, VI, and X. (PubMed id 10531343)¹ Fukuda M....Mikoshiba K. (1999)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 341359	HGNC: 19266	AceView: SYT10	Ensembl:ENSG00000110975	euGenes: HUgn341359
ECgene: SYT10	H-InvDB: SYT10

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SYT10	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SYT10 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SYT10 gene:
Search GeneIP for patents involving SYT10

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


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	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for SYT10		OriGene Custom Protein Services for SYT10
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SYT10
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SYT10
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SYT10
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SYT10
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SYT10
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SYT10

	GenScript Custom Purified and Recombinant Proteins Services for SYT10		GenScript cDNA clones with any tag delivered in your preferred vector for SYT10
	GenScript Custom Assay Services for SYT10		GenScript Custom Superior Antibodies Services for SYT10
	GenScript Custom overexpressing Cell Line Services for SYT10		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYT10

	SwitchGear 3'UTR luciferase reporter plasmids for SYT10
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Search ThermoFisher Antibodies for SYT10

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYT10

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes SYT10 gene at Home site.

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SYT10 Gene

synaptotagmin X

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SYT10 Gene

synaptotagmin X

Aliasesfor SYT10 gene

Summariesfor SYT10 gene

Genomic Viewsfor SYT10 gene

Proteinsfor SYT10 gene

Protein Domains /Familiesfor SYT10 gene

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for SYT10 gene

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for SYT10 gene

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for SYT10 gene

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for SYT10 gene

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for SYT10 gene

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for SYT10 gene

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for SYT10 gene

Expression
for SYT10 gene

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for SYT10 gene

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for SYT10 gene

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for SYT10 gene

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for SYT10 gene

Intellectual Property
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