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Aliases for SYT10 Gene

Aliases for SYT10 Gene

  • Synaptotagmin 10 2 3 5
  • Synaptotagmin X 2 3 4
  • SytX 3 4
  • Synaptotagmin-10 3

External Ids for SYT10 Gene

Previous GeneCards Identifiers for SYT10 Gene

  • GC00U906274
  • GC12M033421
  • GC12M033419
  • GC12M033528
  • GC12M033268

Summaries for SYT10 Gene

GeneCards Summary for SYT10 Gene

SYT10 (Synaptotagmin 10) is a Protein Coding gene. Among its related pathways are Protein-protein interactions at synapses and Transmission across Chemical Synapses. GO annotations related to this gene include calcium ion binding and identical protein binding. An important paralog of this gene is SYT9.

UniProtKB/Swiss-Prot for SYT10 Gene

  • Ca(2+) sensor specifically required for the Ca(2+)-dependent exocytosis of secretory vesicles containing IGF1 in neurons of the olfactory bulb. Exocytosis of IGF1 is required for sensory perception of smell. Not involved in Ca(2+)-dependent synaptic vesicle exocytosis (By similarity). Acts through Ca(2+) and phospholipid binding to the C2 domain: Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYT10 Gene

Genomics for SYT10 Gene

Regulatory Elements for SYT10 Gene

Enhancers for SYT10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F033529 0.5 Ensembl 24.6 -90.0 -89991 0.8 HLF SYT10 RNU6-400P GC12P033476
GH12F033318 0.6 ENCODE 5 +122.5 122547 0.2 SYT10 GC12M033249 ENSG00000259937
GH12F033115 0.4 ENCODE 4.1 +323.5 323459 1.1 JUND SYT10 GC12P033085 GC12P033250 GC12P033249
GH12F033020 0.4 ENCODE 4.1 +418.4 418401 1.2 ZNF680 DPF2 GATAD2B CTBP1 GATA3 ZNF366 RCOR1 CUX1 FOSL2 FOS ENSG00000259937 SYT10 ENSG00000257435 GC12P033085
GH12F034346 0.6 ENCODE 3.9 -907.2 -907168 1.2 ALG10 SYT10 PIR59367 PIR33437
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SYT10 on UCSC Golden Path with GeneCards custom track

Promoters for SYT10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000428880 318 1400 RING1 UBTF ZKSCAN1 E2F1 CTBP1 POLR2A NFYB E2F6 EZH2 RFX1

Genomic Location for SYT10 Gene

Chromosome:
12
Start:
33,374,238 bp from pter
End:
33,439,819 bp from pter
Size:
65,582 bases
Orientation:
Minus strand

Genomic View for SYT10 Gene

Genes around SYT10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SYT10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SYT10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYT10 Gene

Proteins for SYT10 Gene

  • Protein details for SYT10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6XYQ8-SYT10_HUMAN
    Recommended name:
    Synaptotagmin-10
    Protein Accession:
    Q6XYQ8
    Secondary Accessions:
    • Q495U2

    Protein attributes for SYT10 Gene

    Size:
    523 amino acids
    Molecular mass:
    59127 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    • Homodimer; disulfide-linked via the cysteine motif. Can also form heterodimers with SYT3, SYT6, SYT7 and SYT9.

neXtProt entry for SYT10 Gene

Post-translational modifications for SYT10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SYT10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SYT10 Gene

Domains & Families for SYT10 Gene

Gene Families for SYT10 Gene

Protein Domains for SYT10 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SYT10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6XYQ8

UniProtKB/Swiss-Prot:

SYT10_HUMAN :
  • The cysteine motif mediates homo- or heterodimer formation via formation of disulfide bonds.
  • Belongs to the synaptotagmin family.
Domain:
  • The cysteine motif mediates homo- or heterodimer formation via formation of disulfide bonds.
  • The first C2 domain mediates Ca(2+)-dependent phospholipid binding.
  • Contains 2 C2 domains.
Family:
  • Belongs to the synaptotagmin family.
genes like me logo Genes that share domains with SYT10: view

Function for SYT10 Gene

Molecular function for SYT10 Gene

UniProtKB/Swiss-Prot Function:
Ca(2+) sensor specifically required for the Ca(2+)-dependent exocytosis of secretory vesicles containing IGF1 in neurons of the olfactory bulb. Exocytosis of IGF1 is required for sensory perception of smell. Not involved in Ca(2+)-dependent synaptic vesicle exocytosis (By similarity). Acts through Ca(2+) and phospholipid binding to the C2 domain: Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (By similarity).

Gene Ontology (GO) - Molecular Function for SYT10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001786 phosphatidylserine binding IEA --
GO:0005509 calcium ion binding IEA,ISS --
GO:0005544 calcium-dependent phospholipid binding IBA --
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding IEA --
GO:0019905 syntaxin binding IBA --
genes like me logo Genes that share ontologies with SYT10: view
genes like me logo Genes that share phenotypes with SYT10: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SYT10 Gene

Localization for SYT10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYT10 Gene

Cytoplasmic vesicle, secretory vesicle membrane; Single-pass membrane protein. Note=Localizes to neuronal vesicles containing IGF1 that are not enriched at synapses. Does not colocalize with synaptic vesicles or with the Golgi apparatus. {ECO:0000250 UniProtKB:Q9R0N4}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SYT10 Gene COMPARTMENTS Subcellular localization image for SYT10 gene
Compartment Confidence
cytosol 3
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SYT10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030658 transport vesicle membrane IEA --
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with SYT10: view

Pathways & Interactions for SYT10 Gene

genes like me logo Genes that share pathways with SYT10: view

Pathways by source for SYT10 Gene

Interacting Proteins for SYT10 Gene

Gene Ontology (GO) - Biological Process for SYT10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006887 exocytosis IEA --
GO:0006906 vesicle fusion IBA --
GO:0007268 chemical synaptic transmission IEA,ISS --
GO:0007608 sensory perception of smell IEA,ISS --
GO:0016079 NOT synaptic vesicle exocytosis ISS --
genes like me logo Genes that share ontologies with SYT10: view

No data available for SIGNOR curated interactions for SYT10 Gene

Drugs & Compounds for SYT10 Gene

(1) Drugs for SYT10 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with SYT10: view

Transcripts for SYT10 Gene

mRNA/cDNA for SYT10 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SYT10 Gene

Synaptotagmin X:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SYT10 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP1:
SP2: - -

Relevant External Links for SYT10 Gene

GeneLoc Exon Structure for
SYT10
ECgene alternative splicing isoforms for
SYT10

Expression for SYT10 Gene

mRNA expression in normal human tissues for SYT10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SYT10 Gene

This gene is overexpressed in Nerve - Tibial (x8.0), Pituitary (x4.2), and Colon - Sigmoid (x4.1).

Protein differential expression in normal tissues from HIPED for SYT10 Gene

This gene is overexpressed in Pancreatic juice (67.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SYT10 Gene



NURSA nuclear receptor signaling pathways regulating expression of SYT10 Gene:

SYT10

SOURCE GeneReport for Unigene cluster for SYT10 Gene:

Hs.118703

mRNA Expression by UniProt/SwissProt for SYT10 Gene:

Q6XYQ8-SYT10_HUMAN
Tissue specificity: Expressed only in pancreas, lung and kidney.
genes like me logo Genes that share expression patterns with SYT10: view

Primer Products

No data available for Protein tissue co-expression partners for SYT10 Gene

Orthologs for SYT10 Gene

This gene was present in the common ancestor of animals.

Orthologs for SYT10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SYT10 34 35
  • 99.11 (n)
dog
(Canis familiaris)
Mammalia SYT10 34 35
  • 93.3 (n)
cow
(Bos Taurus)
Mammalia SYT10 34 35
  • 91.33 (n)
mouse
(Mus musculus)
Mammalia Syt10 34 16 35
  • 87.19 (n)
rat
(Rattus norvegicus)
Mammalia Syt10 34
  • 87.19 (n)
oppossum
(Monodelphis domestica)
Mammalia SYT10 35
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves SYT10 34 35
  • 81.55 (n)
lizard
(Anolis carolinensis)
Reptilia SYT10 35
  • 86 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii syt10 34 35
  • 67.88 (n)
fruit fly
(Drosophila melanogaster)
Insecta Syt1 35
  • 34 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea snt-3 35
  • 45 (a)
ManyToMany
snt-1 35
  • 35 (a)
ManyToMany
snt-2 35
  • 35 (a)
ManyToMany
Species where no ortholog for SYT10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SYT10 Gene

ENSEMBL:
Gene Tree for SYT10 (if available)
TreeFam:
Gene Tree for SYT10 (if available)

Paralogs for SYT10 Gene

Paralogs for SYT10 Gene

(18) SIMAP similar genes for SYT10 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SYT10: view

Variants for SYT10 Gene

Sequence variations from dbSNP and Humsavar for SYT10 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs10506108 -- 33,380,218(+) ATCAT(A/C)ATAAA intron-variant
rs10506109 -- 33,409,071(+) AATAC(C/G)CAGTC intron-variant
rs10649229 -- 33,395,868(+) AATTC(-/ATT)ATTTC intron-variant
rs10732554 -- 33,380,439(+) ACTTG(C/T)ATTAC intron-variant
rs10743818 -- 33,393,991(+) GAGAA(C/T)TAAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SYT10 Gene

Variant ID Type Subtype PubMed ID
dgv1432n100 CNV gain 25217958
dgv1433n100 CNV gain 25217958
dgv2502n54 CNV gain 21841781
dgv2503n54 CNV gain 21841781
dgv267e214 CNV gain 21293372
dgv268e214 CNV loss 21293372
esv2759892 CNV gain+loss 17122850
esv2761043 CNV gain+loss 21179565
esv34883 CNV gain 17911159
esv3581460 CNV gain 25503493
esv3629113 CNV gain 21293372
esv3629115 CNV loss 21293372
nsv1035988 CNV gain 25217958
nsv1036239 CNV gain 25217958
nsv469348 CNV gain 19166990
nsv558248 CNV gain 21841781
nsv558255 CNV loss 21841781
nsv818908 CNV gain 17921354
nsv820253 CNV loss 19587683
nsv832368 CNV gain 17160897

Variation tolerance for SYT10 Gene

Residual Variation Intolerance Score: 29% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.84; 48.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SYT10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SYT10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SYT10 Gene

Disorders for SYT10 Gene

Relevant External Links for SYT10

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SYT10

No disorders were found for SYT10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SYT10 Gene

Publications for SYT10 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. Cloning and characterization of human synaptotagmin 10 gene. (PMID: 14756426) Zhao E. … Mao Y. (DNA Seq. 2003) 3 4 64
  3. DEAD-box helicase DDX27 regulates 3' end formation of ribosomal 47S RNA and stably associates with the PeBoW-complex. (PMID: 25825154) Kellner M. … Eick D. (Exp. Cell Res. 2015) 3 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. (PMID: 23583979) den Hoed M. … Loos R.J. (Nat. Genet. 2013) 3 64

Products for SYT10 Gene

Sources for SYT10 Gene

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