Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SYT10 Gene

protein-coding   GIFtS: 46
GCID: GC12M033528

Synaptotagmin X

  Search for SYT10
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Synaptotagmin X1 2 3
Synaptotagmin 102
synaptotagmin-102
sytX2
SytX3

External Ids:    HGNC: 192661   Entrez Gene: 3413592   Ensembl: ENSG000001109757   UniProtKB: Q6XYQ83   

Export aliases for SYT10 gene to outside databases

Previous GC identifers: GC00U906274 GC12M033421 GC12M033419 GC12M033268


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for SYT10 Gene:
SYT10 (synaptotagmin X) is a protein-coding gene. GO annotations related to this gene include transporter activity and protein homodimerization activity. An important paralog of this gene is SYT15.

UniProtKB/Swiss-Prot: SYT10_HUMAN, Q6XYQ8
Function: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid
binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis
(By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000012.12  NC_018923.2  NT_009714.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the SYT10 gene promoter:
         SRF   Pbx1a   SRF (504 AA)   p300   FOXD3   CUTL1   YY1   Evi-1   Max   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSYT10 promoter sequence
   Search Chromatin IP Primers for SYT10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SYT10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p11.1   Ensembl cytogenetic band:  12p11.1   HGNC cytogenetic band: 12p11

SYT10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SYT10 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M033528:  view genomic region     (about GC identifiers)

Start:
33,527,173 bp from pter      End:
33,592,754 bp from pter
Size:
65,582 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: SYT10_HUMAN, Q6XYQ8 (See protein sequence)
Recommended Name: Synaptotagmin-10  
Size: 523 amino acids; 59127 Da
Cofactor: Binds 3 calcium ions per subunit. The ions are bound to the C2 domains (By similarity)
Subunit: Homodimer. Can also form heterodimers with SYT6 (By similarity)
Secondary accessions: Q495U2

Explore the universe of human proteins at neXtProt for SYT10: NX_Q6XYQ8

Explore proteomics data for SYT10 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SYT10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_945343.1  
    ENSEMBL proteins: 
     ENSP00000228567   ENSP00000444577   ENSP00000438691  

    SYT10 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for SYT10
    OriGene Custom MassSpec
    OriGene Custom Protein Services for SYT10
    GenScript Custom Purified and Recombinant Proteins Services for SYT10
    Novus Biologicals SYT10 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SYT10

    SYT10 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for SYT10
    OriGene Custom Antibody Services for SYT10
    Novus Biologicals SYT10 Antibodies
    Abcam antibodies for SYT10
    Cloud-Clone Corp. Antibodies for SYT10
    Search ThermoFisher Antibodies for SYT10
    LSBio Antibodies in human, mouse, rat for SYT10

    SYT10 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SYT10
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SYT10
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SYT10
    Cloud-Clone Corp. CLIAs for SYT10


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    SYT: Synaptotagmins

    3 InterPro protein domains:
     IPR028677 SYT10
     IPR001565 Synaptotagmin
     IPR000008 C2_dom

    Graphical View of Domain Structure for InterPro Entry Q6XYQ8

    ProtoNet protein and cluster: Q6XYQ8

    1 Blocks protein domain: IPB000008 C2 domain

    UniProtKB/Swiss-Prot: SYT10_HUMAN, Q6XYQ8
    Similarity: Belongs to the synaptotagmin family
    Similarity: Contains 2 C2 domains


    SYT10 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SYT10_HUMAN, Q6XYQ8
    Function: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid
    binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis
    (By similarity)

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity IEA--
    GO:0005515protein binding ----
    GO:0042802identical protein binding ----
    GO:0042803protein homodimerization activity IEA--
    GO:0046872metal ion binding IEA--
         
    SYT10 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SYT10:
     Decreased Wnt reporter activit 

         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Syt10):
     behavior/neurological  normal 

    SYT10 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SYT10
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SYT10

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SYT10
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SYT10

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat SYT10 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SYT10 (see all 32):
    hsa-miR-448 hsa-miR-15a hsa-miR-548v hsa-miR-301a hsa-miR-221 hsa-miR-3133 hsa-miR-650 hsa-miR-103a
    SwitchGear 3'UTR luciferase reporter plasmidSYT10 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SYT10
    Predesigned siRNA for gene silencing in human, mouse, rat SYT10

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SYT10

    Clone
    Products:
         
    OriGene clones in human, mouse for SYT10 (see all 6)
    OriGene ORF clones in mouse, rat for SYT10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SYT10 (NM_198992)
    Sino Biological Human cDNA Clone for SYT10
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SYT10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYT10

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SYT10
    Browse ESI BIO Cell Lines and PureStem Progenitors for SYT10 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYT10


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    SYT10_HUMAN, Q6XYQ8: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane
    protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    endoplasmic reticulum1
    golgi apparatus1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008021synaptic vesicle ----
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--
    GO:0030054cell junction IEA--
    GO:0030672synaptic vesicle membrane IEA--

    SYT10 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus




        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SYT10
    Interactions:

        Search GeneGlobe Interaction Network for SYT10

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for SYT10 (ENSP000002285674) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SYT3ENSP000003409144STRING: ENSP00000340914
    SYT9ENSP000003244194STRING: ENSP00000324419
    SYT5ENSP000003462654STRING: ENSP00000346265
    --ENSP000003585594STRING: ENSP00000358559
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006950response to stress ----
    GO:0017158regulation of calcium ion-dependent exocytosis IEA--

    SYT10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SYT10

    1 HMDB Compound for SYT10    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for SYT10 gene: 
    NM_198992.3  

    Unigene Cluster for SYT10:

    Synaptotagmin X
    Hs.118703  [show with all ESTs]
    Unigene Representative Sequence: AY198413
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000228567(uc001rll.1 uc009zju.1) ENST00000539102 ENST00000567656
    ENST00000535526
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SYT10 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SYT10 (see all 32):
    hsa-miR-448 hsa-miR-15a hsa-miR-548v hsa-miR-301a hsa-miR-221 hsa-miR-3133 hsa-miR-650 hsa-miR-103a
    SwitchGear 3'UTR luciferase reporter plasmidSYT10 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SYT10
    Predesigned siRNA for gene silencing in human, mouse, rat SYT10
    Clone
    Products:
         
    OriGene clones in human, mouse for SYT10 (see all 6)
    OriGene ORF clones in mouse, rat for SYT10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SYT10 (NM_198992)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SYT10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYT10
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for SYT10
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SYT10
      QuantiTect SYBR Green Assays in human, mouse, rat SYT10
      QuantiFast Probe-based Assays in human, mouse, rat SYT10

    Additional mRNA sequence: 

    AY198413.1 BC101024.2 BC101025.1 

    1 DOTS entry:

    DT.101977138 

    5 AceView cDNA sequences:

    BQ787948 NM_198992 BX479479 BQ777247 AY198413 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for SYT10    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
    SP1:                                                      
    SP2:              -     -                                 


    ECgene alternative splicing isoforms for SYT10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    SYT10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAAAACTAT
    SYT10 Expression
    About this image


    SYT10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Medulla Oblongata
     
     Spinal Cord (Nervous System)
    SYT10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SYT10 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.118703

    UniProtKB/Swiss-Prot: SYT10_HUMAN, Q6XYQ8
    Tissue specificity: Expressed only in pancreas, lung and kidney

        Custom PCR Arrays for SYT10
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for SYT10
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SYT10
    QuantiTect SYBR Green Assays in human, mouse, rat SYT10
    QuantiFast Probe-based Assays in human, mouse, rat SYT10
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYT10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for SYT10 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Syt101 , 5 synaptotagmin X1, 5 87.19(n)1
    92.93(a)1
      15 (44.96 cM)5
    545261  NM_018803.21  NP_061273.11 
     897823935 
    chicken
    (Gallus gallus)
    Aves SYT101 synaptotagmin X 81.55(n)
    88.51(a)
      418129  XM_416361.4  XP_416361.2 
    lizard
    (Anolis carolinensis)
    Reptilia SYT106
    synaptotagmin X
    86(a)
    1 ↔ 1
    GL343678.1(171178-220237)
    zebrafish
    (Danio rerio)
    Actinopterygii syt101 synaptotagmin X 67.88(n)
    75.38(a)
      564226  NM_001082842.1  NP_001076311.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Syt16
    Synaptotagmin 1
    34(a)
    1 → many
    2L(2779267-2799979)
    worm
    (Caenorhabditis elegans)
    Secernentea snt-36
    snt-16
    (see all 3)
    Protein SNT-3
    Protein SNT-1, isoform b (snt-1) mRNA, complete cd...
    (see all 3)
    45(a)
    35(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    V(1358186-1361318) WBGene00004923
    II(6810963-6816454) WBGene00004921


    ENSEMBL Gene Tree for SYT10 (if available)
    TreeFam Gene Tree for SYT10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for SYT10 gene
    SYT152  SYT42  SYT52  SYT92  SYT82  SYT32  SYT62  SYT172  
    SYT112  SYT122  SYT22  SYT72  SYT12  
    18 SIMAP similar genes for SYT10 using alignment to 4 protein entries:     SYT10_HUMAN (see all proteins):
    SYT6    SYT9    SYT2    SYT1    SYT5    SYT7
    SYT3    PRKCG    SYT11    SYTL2    SYT4    DKFZp434D2429
    SYT12    SYT15    CHR11SYT    SYT17    SYT8    RPH3A

    SYT10 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for SYT10 (see all 1405)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1120720441,2
    F--33527899(+) TGTCAT/CTCTAT 1 -- ds50012Minor allele frequency- C:0.04CSA WA 120
    rs123097851,2
    F--33528143(+) GCAGAA/TCTGTG 1 -- ds50013Minor allele frequency- T:0.08CSA WA 122
    rs1482129361,2
    --33528178(+) AAAATA/TTTTAC 1 -- ds50010--------
    rs2020912511,2
    C--33528281(-) TTTTTG/TTAAAA 1 -- ds50010--------
    rs1419535461,2
    --33528296(+) AATTTC/TATAAC 1 -- ds50010--------
    rs1461342511,2
    C--33528499(+) ACTTAA/GAAGAA 1 -- ut310--------
    rs1859226151,2
    --33528560(+) ACCTTA/GATCCT 1 -- ut310--------
    rs1891393021,2
    --33528602(+) GGAGGC/TCTGGG 1 -- ut310--------
    rs1401190981,2
    C--33528772(+) TGTGTA/GCAATC 1 -- ut310--------
    rs1810803021,2
    --33528884(+) ATACAC/TGTCAC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for SYT10 (33527173 - 33592754 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for SYT10:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv820253CNV Loss19587683
    nsv818908CNV Gain17921354
    esv34883CNV Gain17911159
    nsv832368CNV Gain17160897
    nsv469348CNV Gain19166990
    essv5432CNV CNV17122850
    dgv496e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SYT10
    DNA2.0 Custom Variant and Variant Library Synthesis for SYT10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for SYT10 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with SYT10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Cloning and characterization of human synaptotagmin 10 gene. (PubMed id 14756426)1, 2 Zhao E.... Mao Y. (DNA Seq. 2003)
    3. Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. (PubMed id 23583979)1 den Hoed M....Loos R.J. (Nat. Genet. 2013)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    5. Conserved N-terminal cysteine motif is essential for homo- and heterodimer formation of synaptotagmins III, V, VI, and X. (PubMed id 10531343)1 Fukuda M....Mikoshiba K. (J. Biol. Chem. 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 341359 HGNC: 19266 AceView: SYT10 Ensembl:ENSG00000110975 euGenes: HUgn341359
    ECgene: SYT10 H-InvDB: SYT10

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SYT10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SYT10 gene:
    Search GeneIP for patents involving SYT10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for SYT10   OriGene RNAi products in human, mouse, rat for SYT10  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for SYT10  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SYT10  
     OriGene qSTAR qPCR primer pairs in human, mouse for SYT10   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for SYT10   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SYT10   OriGene Custom Protein Services for SYT10  

     
     
     Block miRNA regulation of human, mouse, rat SYT10 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SYT10
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SYT10 Predesigned siRNA for gene silencing in human, mouse, rat SYT10
     QuantiFast Probe-based Assays in human, mouse, rat SYT10 QuantiTect SYBR Green Assays in human, mouse, rat SYT10
     Custom PCR Arrays for SYT10 Search Chromatin IP Primers for SYT10
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SYT10  Search GeneGlobe Interaction Network for SYT10
     Regulatory tfbs in SYT10 promoter
     GenScript Custom Purified and Recombinant Proteins Services for SYT10 GenScript cDNA clones with any tag delivered in your preferred vector for SYT10
     GenScript Custom Assay Services for SYT10 GenScript Custom overexpressing Cell Line Services for SYT10
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for SYT10
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for SYT10
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SYT10 antibodies
     SYT10 lysates
     Antibodies for SYT10
     See all of Abcam's Antibodies, Kits and Proteins for SYT10
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for SYT10
     Antibodies for SYT10
     ELISAs for SYT10
     CLIAs for SYT10



     Browse ESI BIO Cell Lines and PureStem Progenitors for SYT10
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYT10
     SwitchGear 3'UTR luciferase reporter plasmids for SYT10
     SwitchGear Promoter luciferase reporter plasmids for SYT10
     Search ThermoFisher Antibodies for SYT10
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYT10
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SYT10
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SYT10
     LSBio Antibodies in human, mouse, rat for SYT10
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SYT10 gene at Home site.
    Version: 3.12.142 28 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4