External Ids for SYT1 Gene
Previous HGNC Symbols for SYT1 Gene
Previous GeneCards Identifiers for SYT1 Gene
The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin-1 participates in triggering neurotransmitter release at the synapse (Fernandez-Chacon et al., 2001 [PubMed 11242035]).[supplied by OMIM, Jul 2010]
GeneCards Summary for SYT1 Gene
SYT1 (Synaptotagmin I) is a Protein Coding gene. Diseases associated with SYT1 include sarcoma, synovial and diarrhea 1, secretory chloride, congenital. Among its related pathways are Infectious disease and Neuroscience. GO annotations related to this gene include calcium ion binding and transporter activity. An important paralog of this gene is SYT5.
UniProtKB/Swiss-Prot for SYT1 Gene
May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. Plays a role in dendrite formation by melanocytes (PubMed:23999003).