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Aliases for SYS1 Gene

Aliases for SYS1 Gene

  • Sys1 Golgi Trafficking Protein 2 3
  • C20orf169 3 4
  • SYS1 Golgi-Localized Integral Membrane Protein Homolog (S. Cerevisiae) 2
  • SYS1 Golgi-Localized Integral Membrane Protein Homolog 3
  • Chromosome 20 Open Reading Frame 169 2
  • Protein SYS1 Homolog 3
  • DJ453C12.4.1 3
  • DJ453C12.4 3

External Ids for SYS1 Gene

Previous HGNC Symbols for SYS1 Gene

  • C20orf169

Previous GeneCards Identifiers for SYS1 Gene

  • GC20P043424
  • GC20P043990
  • GC20P040733

Summaries for SYS1 Gene

Entrez Gene Summary for SYS1 Gene

  • SYS1 forms a complex with ADP-ribosylation factor-related protein ARFRP1 (MIM 604699) and targets ARFRP1 to the Golgi apparatus (Behnia et al., 2004 [PubMed 15077113]).[supplied by OMIM, Aug 2009]

GeneCards Summary for SYS1 Gene

SYS1 (Sys1 Golgi Trafficking Protein) is a Protein Coding gene. An important paralog of this gene is SYS1-DBNDD2.

UniProtKB/Swiss-Prot for SYS1 Gene

  • Involved in protein trafficking. May serve as a receptor for ARFRP1

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYS1 Gene

Genomics for SYS1 Gene

Regulatory Elements for SYS1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SYS1 Gene

45,361,937 bp from pter
45,376,802 bp from pter
14,866 bases
Plus strand

Genomic View for SYS1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SYS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYS1 Gene

Proteins for SYS1 Gene

  • Protein details for SYS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein SYS1 homolog
    Protein Accession:
    Secondary Accessions:
    • C9JFB3
    • E1P620
    • Q5QPU7
    • Q96SD8
    • Q9BQZ2
    • Q9BQZ4
    • Q9H1F7

    Protein attributes for SYS1 Gene

    156 amino acids
    Molecular mass:
    17615 Da
    Quaternary structure:
    • Interacts with ARFRP1.
    • Sequence=CAC39448.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SYS1 Gene


neXtProt entry for SYS1 Gene

Proteomics data for SYS1 Gene at MOPED

Post-translational modifications for SYS1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for SYS1

No data available for DME Specific Peptides for SYS1 Gene

Domains for SYS1 Gene

Protein Domains for SYS1 Gene

Suggested Antigen Peptide Sequences for SYS1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SYS1 family.
  • Belongs to the SYS1 family.
genes like me logo Genes that share domains with SYS1: view

No data available for Gene Families for SYS1 Gene

Function for SYS1 Gene

Molecular function for SYS1 Gene

UniProtKB/Swiss-Prot Function:
Involved in protein trafficking. May serve as a receptor for ARFRP1

Animal Model Products

miRNA for SYS1 Gene

miRTarBase miRNAs that target SYS1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SYS1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for SYS1 Gene

Localization for SYS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYS1 Gene

Golgi apparatus membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SYS1 Gene COMPARTMENTS Subcellular localization image for SYS1 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 3
vacuole 1

Gene Ontology (GO) - Cellular Components for SYS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane --
GO:0005802 trans-Golgi network IBA --
GO:0016021 integral component of membrane --
GO:0030173 integral component of Golgi membrane IBA --
genes like me logo Genes that share ontologies with SYS1: view

Pathways for SYS1 Gene

SuperPathways for SYS1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SYS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000042 protein targeting to Golgi IBA --
GO:0006895 Golgi to endosome transport IBA --
GO:0015031 protein transport --
GO:0043001 Golgi to plasma membrane protein transport IBA --
genes like me logo Genes that share ontologies with SYS1: view

No data available for Pathways by source for SYS1 Gene

Transcripts for SYS1 Gene

mRNA/cDNA for SYS1 Gene

(3) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SYS1 Gene

SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SYS1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SYS1 Gene

No ASD Table

Relevant External Links for SYS1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SYS1 Gene

mRNA expression in normal human tissues for SYS1 Gene

Protein differential expression in normal tissues for SYS1 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SYS1 Gene

SOURCE GeneReport for Unigene cluster for SYS1 Gene Hs.655055

genes like me logo Genes that share expressions with SYS1: view

Expression partners for SYS1 Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SYS1 Gene

Orthologs for SYS1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SYS1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SYS1 35
  • 95.3 (n)
  • 95.51 (a)
SYS1 36
  • 96 (a)
(Canis familiaris)
Mammalia SYS1 35
  • 96.15 (n)
  • 99.36 (a)
SYS1 36
  • 99 (a)
(Mus musculus)
Mammalia Sys1 35
  • 94.23 (n)
  • 97.44 (a)
Sys1 16
Sys1 36
  • 97 (a)
(Pan troglodytes)
Mammalia SYS1 35
  • 99.79 (n)
  • 99.36 (a)
SYS1 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Sys1 35
  • 93.8 (n)
  • 97.44 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 94 (a)
-- 36
  • 91 (a)
(Gallus gallus)
Aves SYS1 35
  • 77.99 (n)
  • 79.49 (a)
SYS1 36
  • 77 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sys1 35
  • 68.16 (n)
  • 76.92 (a)
(Danio rerio)
Actinopterygii sys1 35
  • 69.66 (n)
  • 73.72 (a)
sys1 36
  • 74 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001975 35
  • 57.14 (n)
  • 46.1 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11753 35
  • 52.26 (n)
  • 42.58 (a)
CG11753 36
  • 41 (a)
(Caenorhabditis elegans)
Secernentea T03F1.12 35
  • 44.92 (n)
  • 36.88 (a)
T03F1.12 36
  • 34 (a)
(Oryza sativa)
Liliopsida Os01g0593600 35
  • 54.63 (n)
  • 43.06 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 48 (a)
Species with no ortholog for SYS1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SYS1 Gene

Gene Tree for SYS1 (if available)
Gene Tree for SYS1 (if available)

Paralogs for SYS1 Gene

Paralogs for SYS1 Gene

(1) SIMAP similar genes for SYS1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SYS1: view

Variants for SYS1 Gene

Sequence variations from dbSNP and Humsavar for SYS1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs2741432 -- 45,360,874(-) agtgg(C/T)gcaat upstream-variant-2KB
rs2741433 -- 45,360,589(-) CCATT(G/T)TGGCC upstream-variant-2KB
rs2741434 -- 45,360,394(-) AAGCA(A/G)TCCTC upstream-variant-2KB
rs2743407 -- 45,360,290(+) cctcc(C/T)ttcct upstream-variant-2KB
rs2743408 -- 45,360,590(+) GCCAC(A/C)ATGGT upstream-variant-2KB

Relevant External Links for SYS1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SYS1 Gene

Disorders for SYS1 Gene

(1) University of Copenhagen DISEASES for SYS1 Gene

genes like me logo Genes that share disorders with SYS1: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships , Genatlas and External Links for SYS1 Gene

Publications for SYS1 Gene

  1. Targeting of the Arf-like GTPase Arl3p to the Golgi requires N- terminal acetylation and the membrane protein Sys1p. (PMID: 15077113) Behnia R. … Munro S. (Nat. Cell Biol. 2004) 2 3 4
  2. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3
  5. Quantitative Lys-I/-Gly-Gly (diGly) proteomics coupled with inducible RNAi reveals ubiquitin-mediated proteolysis of DNA damage-inducible transcript 4 (DDIT4) by the E3 ligase HUWE1. (PMID: 25147182) Thompson J.W. … Luchansky S.J. (J. Biol. Chem. 2014) 3

Products for SYS1 Gene

Sources for SYS1 Gene

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