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Aliases for SYPL2 Gene

Aliases for SYPL2 Gene

  • Synaptophysin-Like 2 2 3
  • Mitsugumin-29 2 3
  • Synaptophysin-Like Protein 2 3
  • Mitsugumin 29 3
  • MG29 3

External Ids for SYPL2 Gene

Previous GeneCards Identifiers for SYPL2 Gene

  • GC01P109722
  • GC01P110010
  • GC01P107902

Summaries for SYPL2 Gene

GeneCards Summary for SYPL2 Gene

SYPL2 (Synaptophysin-Like 2) is a Protein Coding gene. GO annotations related to this gene include transporter activity. An important paralog of this gene is SYNPR.

UniProtKB/Swiss-Prot for SYPL2 Gene

  • Involved in communication between the T-tubular and junctional sarcoplasmic reticulum (SR) membranes.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYPL2 Gene

Genomics for SYPL2 Gene

Regulatory Elements for SYPL2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SYPL2 Gene

109,466,478 bp from pter
109,482,142 bp from pter
15,665 bases
Plus strand

Genomic View for SYPL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SYPL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYPL2 Gene

Proteins for SYPL2 Gene

  • Protein details for SYPL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Synaptophysin-like protein 2
    Protein Accession:
    Secondary Accessions:
    • A8K0E8
    • A8KAL7
    • I0IT67
    • Q6ZMX1

    Protein attributes for SYPL2 Gene

    272 amino acids
    Molecular mass:
    30156 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SYPL2 Gene


neXtProt entry for SYPL2 Gene

Proteomics data for SYPL2 Gene at MOPED

Post-translational modifications for SYPL2 Gene

  • Glycosylation at Asn213
  • Modification sites at PhosphoSitePlus

Other Protein References for SYPL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SYPL2 Gene

Domains for SYPL2 Gene

Protein Domains for SYPL2 Gene


Suggested Antigen Peptide Sequences for SYPL2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q5VXT5
  • Contains 1 MARVEL domain.
  • Belongs to the synaptophysin/synaptobrevin family.
genes like me logo Genes that share domains with SYPL2: view

No data available for Gene Families for SYPL2 Gene

Function for SYPL2 Gene

Molecular function for SYPL2 Gene

UniProtKB/Swiss-Prot Function:
Involved in communication between the T-tubular and junctional sarcoplasmic reticulum (SR) membranes.

Gene Ontology (GO) - Molecular Function for SYPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity IEA --
genes like me logo Genes that share ontologies with SYPL2: view

Phenotypes for SYPL2 Gene

genes like me logo Genes that share phenotypes with SYPL2: view

Animal Models for SYPL2 Gene

MGI Knock Outs for SYPL2:

Animal Model Products

CRISPR Products

miRNA for SYPL2 Gene

miRTarBase miRNAs that target SYPL2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SYPL2 Gene

Localization for SYPL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYPL2 Gene

Membrane; Multi-pass membrane protein. Note=Triad junction, the junctional complex between the transverse tubule and the sarcoplasmic reticulum. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for SYPL2 Gene COMPARTMENTS Subcellular localization image for SYPL2 gene
Compartment Confidence
plasma membrane 3
endoplasmic reticulum 2

Gene Ontology (GO) - Cellular Components for SYPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008021 synaptic vesicle IEA --
GO:0016020 membrane --
GO:0030285 integral component of synaptic vesicle membrane IBA --
genes like me logo Genes that share ontologies with SYPL2: view

Pathways for SYPL2 Gene

SuperPathways for SYPL2 Gene

No Data Available

Interacting Proteins for SYPL2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000358888 for SYPL2 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for SYPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006874 cellular calcium ion homeostasis IEA --
GO:0021762 substantia nigra development IEP 22926577
genes like me logo Genes that share ontologies with SYPL2: view

No data available for Pathways by source for SYPL2 Gene

Compounds for SYPL2 Gene

(2) Novoseek inferred chemical compound relationships for SYPL2 Gene

Compound -log(P) Hits PubMed IDs
ryanodine 56.9 2
calcium 21.8 2
genes like me logo Genes that share compounds with SYPL2: view

Transcripts for SYPL2 Gene

Unigene Clusters for SYPL2 Gene

Synaptophysin-like 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SYPL2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SYPL2 Gene

No ASD Table

Relevant External Links for SYPL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SYPL2 Gene

mRNA expression in normal human tissues for SYPL2 Gene

mRNA differential expression in normal tissues according to GTEx for SYPL2 Gene

This gene is overexpressed in Muscle - Skeletal (27.5).

Protein differential expression in normal tissues for SYPL2 Gene

This gene is overexpressed in Tonsil (29.7), Oral epithelium (11.5), and Esophagus (6.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SYPL2 Gene

SOURCE GeneReport for Unigene cluster for SYPL2 Gene Hs.528366

genes like me logo Genes that share expressions with SYPL2: view

Expression partners for SYPL2 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for SYPL2 Gene

Orthologs for SYPL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SYPL2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SYPL2 35
  • 92.17 (n)
  • 93.56 (a)
SYPL2 36
  • 66 (a)
(Canis familiaris)
Mammalia SYPL2 35
  • 87.57 (n)
  • 88.11 (a)
SYPL2 36
  • 82 (a)
(Mus musculus)
Mammalia Sypl2 35
  • 90.78 (n)
  • 93.18 (a)
Sypl2 16
Sypl2 36
  • 94 (a)
(Pan troglodytes)
Mammalia SYPL2 35
  • 99.37 (n)
  • 100 (a)
SYPL2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Sypl2 35
  • 90.53 (n)
  • 93.56 (a)
(Monodelphis domestica)
Mammalia SYPL2 36
  • 90 (a)
(Ornithorhynchus anatinus)
Mammalia SYPL2 36
  • 87 (a)
(Gallus gallus)
Aves SYPL2 35
  • 73.72 (n)
  • 72.92 (a)
SYPL2 36
  • 70 (a)
(Anolis carolinensis)
Reptilia SYPL2 36
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sypl2 35
  • 63.55 (n)
  • 62.55 (a)
(Danio rerio)
Actinopterygii sypl2a 36
  • 44 (a)
sypl2b 36
  • 48 (a)
(Caenorhabditis elegans)
Secernentea sph-1 36
  • 24 (a)
Species with no ortholog for SYPL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SYPL2 Gene

Gene Tree for SYPL2 (if available)
Gene Tree for SYPL2 (if available)

Paralogs for SYPL2 Gene

Paralogs for SYPL2 Gene

Selected SIMAP similar genes for SYPL2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SYPL2: view

Variants for SYPL2 Gene

Sequence variations from dbSNP and Humsavar for SYPL2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs485660 -- 109,480,810(+) CTTTG(A/G)GACCC utr-variant-3-prime
rs491285 -- 109,476,380(-) AGGTT(A/G)GAATC intron-variant
rs518697 -- 109,472,156(-) cagag(C/T)gagac intron-variant
rs529091 -- 109,472,353(-) tggga(G/T)gctga intron-variant
rs530565 -- 109,475,526(+) GTTCT(C/T)GACTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SYPL2 Gene

Variant ID Type Subtype PubMed ID
nsv872141 CNV Loss 21882294

Relevant External Links for SYPL2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SYPL2 Gene

Disorders for SYPL2 Gene

Relevant External Links for SYPL2

Genetic Association Database (GAD)

No disorders were found for SYPL2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for SYPL2 Gene

Publications for SYPL2 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  2. Genome-wide association study of recurrent early-onset major depressive disorder. (PMID: 20125088) Shi J. … Levinson D.F. (Mol. Psychiatry 2011) 3 48
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Mitsugumin 29 is transcriptionally induced in senile plaque- associated astrocytes. (PMID: 22290180) Satoh K. … Yamada T. (Brain Res. 2012) 3 4

Products for SYPL2 Gene

Sources for SYPL2 Gene

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