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SYPL2 Gene

protein-coding   GIFtS: 46
GCID: GC01P110010

Synaptophysin-Like 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Synaptophysin-Like 21 2
mitsugumin-291 2
MG292
Mitsugumin 292
Synaptophysin-Like Protein 22

External Ids:    HGNC: 276381   Entrez Gene: 2846122   Ensembl: ENSG000001430287   UniProtKB: Q5VXT53   

Export aliases for SYPL2 gene to outside databases

Previous GC identifers: GC01P109722 GC01P107902


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SYPL2 Gene:
SYPL2 (synaptophysin-like 2) is a protein-coding gene. GO annotations related to this gene include transporter activity. An important paralog of this gene is SYNPR.

UniProtKB/Swiss-Prot: SYPL2_HUMAN, Q5VXT5
Function: Involved in communication between the T-tubular and junctional sarcoplasmic reticulum (SR) membranes (By
similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SYPL2 gene promoter:
         NF-kappaB   NF-E2 p45   CREB   NF-kappaB2   deltaCREB   LyF-1   NF-E2   NF-kappaB1   ATF6   RSRFC4   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for SYPL2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SYPL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13.3   Ensembl cytogenetic band:  1p13.3   HGNC cytogenetic band: 1p13.3

SYPL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SYPL2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P110010:  view genomic region     (about GC identifiers)

Start:
110,009,100 bp from pter      End:
110,024,764 bp from pter
Size:
15,665 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SYPL2_HUMAN, Q5VXT5 (See protein sequence)
Recommended Name: Synaptophysin-like protein 2  
Size: 272 amino acids; 30156 Da
Secondary accessions: A8K0E8 A8KAL7 I0IT67 Q6ZMX1
Alternative splicing: 2 isoforms:  Q5VXT5-1   Q5VXT5-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SYPL2: NX_Q5VXT5

Explore proteomics data for SYPL2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn213
  • Modification sites at PhosphoSitePlus

  • See SYPL2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001035799.1  
    ENSEMBL proteins: 
     ENSP00000358888   ENSP00000383805  

    SYPL2 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for SYPL2
    OriGene Custom MassSpec
    OriGene Custom Protein Services for SYPL2
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    Novus Biologicals SYPL2 Protein
    Novus Biologicals SYPL2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SYPL2

     
    Search eBioscience for Proteins for SYPL2 

     
    Search antibodies-online for proteins for SYPL2 

     
    antibodies-online peptides for SYPL2

    SYPL2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for SYPL2
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    ThermoFisher Antibodies for SYPL2
    antibodies-online antibodies for SYPL2 (10 products) 

    SYPL2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SYPL2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SYPL2
    Cloud-Clone Corp. CLIAs for SYPL2
    Search eBioscience for ELISAs for SYPL2 
    antibodies-online kits for SYPL2 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR001285 Synaptophysin/porin
     IPR008253 Marvel

    Graphical View of Domain Structure for InterPro Entry Q5VXT5

    ProtoNet protein and cluster: Q5VXT5

    1 Blocks protein domain: IPB008253 Marvel

    UniProtKB/Swiss-Prot: SYPL2_HUMAN, Q5VXT5
    Similarity: Belongs to the synaptophysin/synaptobrevin family
    Similarity: Contains 1 MARVEL domain


    Find genes that share domains with SYPL2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SYPL2_HUMAN, Q5VXT5
    Function: Involved in communication between the T-tubular and junctional sarcoplasmic reticulum (SR) membranes (By
    similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity IEA--
         
    Find genes that share ontologies with SYPL2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SYPL2:
     Synthetic lethal with Ras 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Sypl2):
     behavior/neurological  growth/size/body  muscle 

    Find genes that share phenotypes with SYPL2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Sypl2tm1Hta for SYPL2

       genOway: Develop your customized and physiologically relevant rodent model for SYPL2

    miRNA
    Products:
        
    miRTarBase miRNAs that target SYPL2:
    hsa-mir-615-3p (MIRT039687)

    Block miRNA regulation of human, mouse, rat SYPL2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SYPL2 (see all 23):
    hsa-miR-3194-5p hsa-miR-607 hsa-miR-4272 hsa-miR-29a hsa-miR-29c hsa-miR-765 hsa-miR-570 hsa-miR-1208
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SYPL2

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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SYPL2 (NM_001040709)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SYPL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYPL2

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    Browse ESI BIO Cell Lines and PureStem Progenitors for SYPL2 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYPL2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SYPL2_HUMAN, Q5VXT5: Membrane; Multi-pass membrane protein (By similarity). Note=Triad junction, the junctional
    complex between the transverse tubule and the sarcoplasmic reticulum (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    endoplasmic reticulum2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008021synaptic vesicle ----
    GO:0016020membrane ----
    GO:0016021integral component of membrane ----
    GO:0030285integral component of synaptic vesicle membrane IBA--

    Find genes that share ontologies with SYPL2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SYPL2
    Interactions:

        Search GeneGlobe Interaction Network for SYPL2

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006874cellular calcium ion homeostasis IEA--
    GO:0021762substantia nigra development IEP--

    Find genes that share ontologies with SYPL2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SYPL2

    2 Novoseek inferred chemical compound relationships for SYPL2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ryanodine 56.9 2 11988740 (1), 12456355 (1)
    calcium 21.8 4 16943181 (2)



    Find genes that share compounds with SYPL2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SYPL2 gene (2 alternative transcripts): 
    NM_001006603.1  NM_001040709.1  

    Unigene Cluster for SYPL2:

    Synaptophysin-like 2
    Hs.528366  [show with all ESTs]
    Unigene Representative Sequence: NM_001040709
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369872(uc001dxo.2 uc001dxq.2 uc001dxp.3 uc010ovk.2)
    ENST00000475497 ENST00000401021
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SYPL2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SYPL2 (see all 23):
    hsa-miR-3194-5p hsa-miR-607 hsa-miR-4272 hsa-miR-29a hsa-miR-29c hsa-miR-765 hsa-miR-570 hsa-miR-1208
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for SYPL2
    Predesigned siRNA for gene silencing in human, mouse, rat SYPL2
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SYPL2 (NM_001040709)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SYPL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYPL2
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for SYPL2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SYPL2
      QuantiTect SYBR Green Assays in human, mouse, rat SYPL2
      QuantiFast Probe-based Assays in human, mouse, rat SYPL2

    Additional mRNA sequence: 

    AB158472.1 AK095168.1 AK289513.1 AK293082.1 AK301509.1 AK302566.1 AY358862.1 BC110407.1 
    BC113102.1 BC113103.1 

    2 DOTS entries:

    DT.75101019  DT.97796131 

    Selected AceView cDNA sequences (see all 31):

    AY358862 BX093337 BM561680 AW590829 AW611858 BM021534 AW196238 AK131459 
    AW271199 F35765 AA442429 BF791734 AK095168 BX500858 CK904347 AI476332 
    T11509 BX282727 AI089671 AA946911 AI146436 AI983207 AW242844 BF982139 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SYPL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SYPL2 Expression
    About this image

    SYPL2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SYPL2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.528366
        Custom PCR Arrays for SYPL2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYPL2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SYPL2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sypl21 , 5 synaptophysin-like 21, 5 90.78(n)1
    93.18(a)1
      3 (46.87 cM)5
    173061  NM_008596.11  NP_032622.11 
     1082114725 
    chicken
    (Gallus gallus)
    Aves SYPL21 synaptophysin-like 2 73.72(n)
    72.92(a)
      100858920  XM_003643372.2  XP_003643420.2 
    lizard
    (Anolis carolinensis)
    Reptilia SYPL26
    synaptophysin-like 2
    69(a)
    1 ↔ 1
    4(105516122-105536216)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia sypl21 synaptophysin-like 2 63.55(n)
    62.55(a)
      448559  NM_001006110.1  NP_001006110.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sypl2b6
    sypl2a6
    synaptophysin-like 2a
    48(a)
    44(a)
    1 ↔ many
    1 ↔ many
    8(25932413-25943401) ENSDARG00000000690
    11(37196137-37216862) ENSDARG00000055307
    worm
    (Caenorhabditis elegans)
    Secernentea sph-16
    Protein SPH-1 (sph-1) mRNA, complete cds
    24(a)
    1 → many
    IV(8132175-8133692) WBGene00004979


    ENSEMBL Gene Tree for SYPL2 (if available)
    TreeFam Gene Tree for SYPL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SYPL2 gene
    SYNPR2  SYPL12  SYP2  
    4 SIMAP similar genes for SYPL2 using alignment to 3 protein entries:     SYPL2_HUMAN (see all proteins):
    SYPL1    SYPL    SYNPR    SYP

    Find genes that share paralogs with SYPL2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SYPL2 (see all 334)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1476142061,2
    C--110007152(+) TTAACA/GAGGCT 1 -- us2k10--------
    rs1166555321,2
    C,F--110007243(+) GACATT/CGGTAA 1 -- us2k11Minor allele frequency- C:0.03WA 118
    rs1421086731,2
    C--110007283(+) GCATTC/TACATA 1 -- us2k10--------
    rs1430850551,2
    --110007438(+) GTCTAC/GATTTG 1 -- us2k10--------
    rs1812083801,2
    --110007590(+) CAAATA/GTTTGT 1 -- us2k10--------
    rs42465171,2
    C,F,A,H--110007636(+) GGTTGC/GGGGGG 1 -- us2k112Minor allele frequency- G:0.32NS EA NA WA 782
    rs17657561,2
    C,F,A,H--110007652(-) CATTCT/CTGCAG 1 -- us2k125Minor allele frequency- C:0.16MN NS EA NA WA CSA 2535
    rs1864121591,2
    --110007796(+) GCCAAA/GTGCTT 1 -- us2k10--------
    rs729850091,2
    C,F--110007830(+) CAGTTA/TAAAAA 1 -- us2k12Minor allele frequency- T:0.07WA 120
    rs3710197271,2
    C--110007905(+) CTTTC-/TTTTTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SYPL2 (110009100 - 110024764 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SYPL2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv872141CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SYPL2
    DNA2.0 Custom Variant and Variant Library Synthesis for SYPL2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with SYPL2           About GenesLikeMe

    Genetic Association Database (GAD): SYPL2

    Export disorders for SYPL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SYPL2 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with SYPL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mitsugumin 29 is transcriptionally induced in senile plaque- associated astrocytes. (PubMed id 22290180)1, 2 Satoh K.... Yamada T. (Brain Res. 2012)
    2. Genome-wide association study of recurrent early-onset major depressive disorder. (PubMed id 20125088)1, 4 Shi J....Levinson D.F. (Mol. Psychiatry 2011)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 3 Clark H.F.... Gray A.M. (Genome Res. 2003)
    6. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    7. New loci associated with kidney function and chronic kidney disease. (PubMed id 20383146)1 KAPttgen A....Fox C.S. (Nat. Genet. 2010)
    8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. Muscle aging is associated with compromised Ca2+ spark signaling and segregated intracellular Ca2+ release. (PubMed id 16943181)9 Weisleder N....Ma J. (J. Cell Biol. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 284612 HGNC: 27638 AceView: LOC284612 Ensembl:ENSG00000143028 euGenes: HUgn284612
    ECgene: SYPL2 H-InvDB: SYPL2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SYPL2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SYPL2 gene:
    Search GeneIP for patents involving SYPL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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