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Aliases for SYPL2 Gene

Aliases for SYPL2 Gene

  • Synaptophysin Like 2 2 3 5
  • Synaptophysin-Like Protein 2 3
  • Synaptophysin-Like 2 2
  • Mitsugumin-29 2
  • Mitsugumin 29 3
  • MG29 3

External Ids for SYPL2 Gene

Previous GeneCards Identifiers for SYPL2 Gene

  • GC01P109722
  • GC01P110010
  • GC01P107902

Summaries for SYPL2 Gene

GeneCards Summary for SYPL2 Gene

SYPL2 (Synaptophysin Like 2) is a Protein Coding gene. GO annotations related to this gene include transporter activity. An important paralog of this gene is SYNPR.

UniProtKB/Swiss-Prot for SYPL2 Gene

  • Involved in communication between the T-tubular and junctional sarcoplasmic reticulum (SR) membranes.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYPL2 Gene

Genomics for SYPL2 Gene

Regulatory Elements for SYPL2 Gene

Enhancers for SYPL2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G109296 1.9 FANTOM5 Ensembl ENCODE dbSUPER 40.9 -167.4 -167440 4.4 PKNOX1 FOXA2 MLX ARNT ARID4B DMAP1 SLC30A9 ZNF766 ZNF263 ZHX2 SYPL2 MYBPHL ATXN7L2 SORT1 PSRC1
GH01G109305 1.8 FANTOM5 Ensembl ENCODE dbSUPER 43 -159.4 -159436 2.8 HNRNPUL1 ATF1 PKNOX1 ARNT TCF12 GATA2 FOS JUNB NCOA1 MEF2D SYPL2 WDR47 MYBPHL GC01P109313
GH01G109368 2 FANTOM5 Ensembl ENCODE dbSUPER 38.5 -93.9 -93911 8.2 HDGF FOXA2 PKNOX1 CREB3L1 ARNT SIN3A DMAP1 ZNF2 ZNF766 CBX5 SYPL2 ENSG00000258634 RPL17P7 PRPF38B AMIGO1 ATXN7L2 SORT1 GC01P109313
GH01G109382 1.4 Ensembl ENCODE dbSUPER 46.6 -82.7 -82732 2.3 ELF3 ATF1 FOXA2 CBX3 ARID4B TCF12 ZNF121 EGR1 ZSCAN5C SCRT2 SYPL2 MYBPHL PSRC1 SORT1 GC01P109313
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SYPL2 on UCSC Golden Path with GeneCards custom track

Promoters for SYPL2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000253463 222 601 ZNF76 RAD21 YY1 GLIS2 EGR1 ZNF366 KLF7 EGR2 ZNF263 SP3
ENSR00000011088 822 201 SCRT1 ZFHX2 ZNF76 EZH2

Genomic Location for SYPL2 Gene

109,466,478 bp from pter
109,482,142 bp from pter
15,665 bases
Plus strand

Genomic View for SYPL2 Gene

Genes around SYPL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SYPL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SYPL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYPL2 Gene

Proteins for SYPL2 Gene

  • Protein details for SYPL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Synaptophysin-like protein 2
    Protein Accession:
    Secondary Accessions:
    • A8K0E8
    • A8KAL7
    • I0IT67
    • Q6ZMX1

    Protein attributes for SYPL2 Gene

    272 amino acids
    Molecular mass:
    30156 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SYPL2 Gene


neXtProt entry for SYPL2 Gene

Post-translational modifications for SYPL2 Gene

  • Glycosylation at Asn213
  • Modification sites at PhosphoSitePlus

Other Protein References for SYPL2 Gene

No data available for DME Specific Peptides for SYPL2 Gene

Domains & Families for SYPL2 Gene

Protein Domains for SYPL2 Gene


Suggested Antigen Peptide Sequences for SYPL2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the synaptophysin/synaptobrevin family.
  • Belongs to the synaptophysin/synaptobrevin family.
genes like me logo Genes that share domains with SYPL2: view

No data available for Gene Families for SYPL2 Gene

Function for SYPL2 Gene

Molecular function for SYPL2 Gene

UniProtKB/Swiss-Prot Function:
Involved in communication between the T-tubular and junctional sarcoplasmic reticulum (SR) membranes.

Gene Ontology (GO) - Molecular Function for SYPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity IEA --
genes like me logo Genes that share ontologies with SYPL2: view
genes like me logo Genes that share phenotypes with SYPL2: view

Animal Models for SYPL2 Gene

MGI Knock Outs for SYPL2:

Animal Model Products

  • Taconic Biosciences Mouse Models for SYPL2

CRISPR Products

miRNA for SYPL2 Gene

miRTarBase miRNAs that target SYPL2

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SYPL2 Gene

Localization for SYPL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYPL2 Gene

Membrane; Multi-pass membrane protein. Note=Triad junction, the junctional complex between the transverse tubule and the sarcoplasmic reticulum. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SYPL2 gene
Compartment Confidence
plasma membrane 4
endoplasmic reticulum 2

Gene Ontology (GO) - Cellular Components for SYPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008021 synaptic vesicle IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030285 integral component of synaptic vesicle membrane IBA --
genes like me logo Genes that share ontologies with SYPL2: view

Pathways & Interactions for SYPL2 Gene

SuperPathways for SYPL2 Gene

No Data Available

Interacting Proteins for SYPL2 Gene

Selected Interacting proteins: Q5VXT5-SYPL2_HUMAN for SYPL2 Gene via IID

Gene Ontology (GO) - Biological Process for SYPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006874 cellular calcium ion homeostasis IEA --
GO:0021762 substantia nigra development IEP 22926577
genes like me logo Genes that share ontologies with SYPL2: view

No data available for Pathways by source and SIGNOR curated interactions for SYPL2 Gene

Drugs & Compounds for SYPL2 Gene

(2) Drugs for SYPL2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with SYPL2: view

Transcripts for SYPL2 Gene

Unigene Clusters for SYPL2 Gene

Synaptophysin-like 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SYPL2 Gene

No ASD Table

Relevant External Links for SYPL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SYPL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SYPL2 Gene

mRNA differential expression in normal tissues according to GTEx for SYPL2 Gene

This gene is overexpressed in Muscle - Skeletal (x27.5).

Protein differential expression in normal tissues from HIPED for SYPL2 Gene

This gene is overexpressed in Tonsil (29.7), Oral epithelium (11.5), and Esophagus (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SYPL2 Gene

Protein tissue co-expression partners for SYPL2 Gene

NURSA nuclear receptor signaling pathways regulating expression of SYPL2 Gene:


SOURCE GeneReport for Unigene cluster for SYPL2 Gene:


Evidence on tissue expression from TISSUES for SYPL2 Gene

  • Muscle(4.5)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with SYPL2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SYPL2 Gene

Orthologs for SYPL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SYPL2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SYPL2 34 35
  • 99.37 (n)
(Bos Taurus)
Mammalia SYPL2 34 35
  • 92.17 (n)
(Mus musculus)
Mammalia Sypl2 34 16 35
  • 90.78 (n)
(Rattus norvegicus)
Mammalia Sypl2 34
  • 90.53 (n)
(Monodelphis domestica)
Mammalia SYPL2 35
  • 90 (a)
(Canis familiaris)
Mammalia SYPL2 34 35
  • 87.57 (n)
(Ornithorhynchus anatinus)
Mammalia SYPL2 35
  • 87 (a)
(Gallus gallus)
Aves SYPL2 34 35
  • 73.72 (n)
(Anolis carolinensis)
Reptilia SYPL2 35
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sypl2 34
  • 63.55 (n)
(Danio rerio)
Actinopterygii sypl2b 35
  • 48 (a)
sypl2a 35
  • 44 (a)
(Caenorhabditis elegans)
Secernentea sph-1 35
  • 24 (a)
Species where no ortholog for SYPL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SYPL2 Gene

Gene Tree for SYPL2 (if available)
Gene Tree for SYPL2 (if available)

Paralogs for SYPL2 Gene

Paralogs for SYPL2 Gene

(4) SIMAP similar genes for SYPL2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SYPL2: view

Variants for SYPL2 Gene

Sequence variations from dbSNP and Humsavar for SYPL2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000187710 -- 109,477,892(+) ACCGA(C/T)GTCAA intron-variant, reference, synonymous-codon
rs1000404662 -- 109,477,947(+) GCCAT(G/T)GAGAG intron-variant, reference, stop-gained
rs1000604968 -- 109,471,706(+) CACCA(A/C)ACCCG intron-variant
rs1000683070 -- 109,467,393(+) GCTCA(C/T)ATTTC intron-variant
rs1001003611 -- 109,465,976(+) GGTCT(C/G)GAACT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SYPL2 Gene

Variant ID Type Subtype PubMed ID
esv3578079 CNV loss 25503493

Variation tolerance for SYPL2 Gene

Residual Variation Intolerance Score: 70.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.59; 65.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SYPL2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SYPL2 Gene

Disorders for SYPL2 Gene

Relevant External Links for SYPL2

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SYPL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SYPL2 Gene

Publications for SYPL2 Gene

  1. Mitsugumin 29 is transcriptionally induced in senile plaque- associated astrocytes. (PMID: 22290180) Satoh K. … Yamada T. (Brain Res. 2012) 3 4 64
  2. Genome-wide association study of recurrent early-onset major depressive disorder. (PMID: 20125088) Shi J. … Levinson D.F. (Mol. Psychiatry 2011) 3 46 64
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 64

Products for SYPL2 Gene

Sources for SYPL2 Gene

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