SYPL2 Gene
protein-coding GIFtS: 41
GCID: GC01P110010
|
|
synaptophysin-like 2
| |
Aliases
for SYPL2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Synaptophysin-Like 21 2 | | Mg291 | | MG292 | | Mitsugumin 292 | | Mitsugumin-291 | | Synaptophysin-Like Protein 22 |
Export aliases for SYPL2 gene to outside databasesPrevious GC identifers: GC01P109722 GC01P107902 |
Summaries
for SYPL2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: SYPL2_HUMAN, Q5VXT5Function: Involved in communication between the T-tubular and junctional sarcoplasmic reticulum (SR) membranes (Bysimilarity)
|
Genomic Views
for SYPL2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_032977.9
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SYPL2 gene promoter:
NF-kappaB NF-E2 p45 CREB NF-kappaB2 deltaCREB LyF-1 NF-E2 NF-kappaB1 ATF6 RSRFC4
Other transcription factors
Search SABiosciences Chromatin IP Primers for SYPL2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SYPL2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p13.3 Ensembl cytogenetic band: 1p13.3 HGNC cytogenetic band: 1p13.3SYPL2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P110010: view genomic region
(about GC identifiers)
Start:
|
110,009,100 bp from pter |
End:
|
110,024,764 bp from pter |
Size:
|
15,665 bases |
Orientation:
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plus strand |
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Proteins
for SYPL2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SYPL2_HUMAN, Q5VXT5 (See
protein sequence)Recommended Name: Synaptophysin-like protein 2 Size: 272 amino acids; 30156 Da
Subcellular location: Membrane; Multi-pass membrane protein (By similarity). Note=Triad junction, the junctionalcomplex between the transverse tubule and the sarcoplasmic reticulum (By similarity)
Secondary accessions: A8K0E8 A8KAL7 I0IT67 Q6ZMX1Alternative splicing: 2 isoforms: Q5VXT5-1 Q5VXT5-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SYPL2: NX_Q5VXT5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5VXT5
SYPL2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001035799.1
ENSEMBL proteins: ENSP00000358888 ENSP00000383805
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008021 | synaptic vesicle |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
SYPL2 for ontologies About GeneDecksing
SYPL2 Antibody Products:
Assay Products for SYPL2: |
Protein
Domains /
Families
for SYPL2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SYPL2 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q5VXT5ProtoNet protein and cluster: Q5VXT5 1 Blocks protein family: IPB008253 Marvel
UniProtKB/Swiss-Prot: SYPL2_HUMAN, Q5VXT5Similarity: Belongs to the synaptophysin/synaptobrevin familySimilarity: Contains 1 MARVEL domain |
Function
for SYPL2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SYPL2_HUMAN, Q5VXT5Function: Involved in communication between the T-tubular and junctional sarcoplasmic reticulum (SR) membranes (Bysimilarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SYPL2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SYPL2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SYPL2 (NM_001040709) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SYPL2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYPL2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYPL2 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005215 | transporter activity |
IEA | -- |
SYPL2 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for SYPL2:
Animal Models:
Mouse knock-out Sypl2tm1Hta for SYPL2
3 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Sypl2):
SYPL2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for SYPL2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SYPL2
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006874 | cellular calcium ion homeostasis |
IEA | -- |
SYPL2 for ontologies About GeneDecksing
|
Drugs & Compounds
for SYPL2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
SYPL2 for compounds About GeneDecksing
 Browse Tocris compounds for SYPL2
2 Novoseek chemical compound relationships for SYPL2 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| ryanodine |
56.9 |
2 |
11988740 (1), 12456355 (1) |
| calcium |
21.8 |
4 |
16943181 (2) |
Search CenterWatch for drugs/clinical trials and news about SYPL2
|
Transcripts
for SYPL2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SYPL2 gene (2 alternative transcripts): NM_001006603.1 NM_001040709.1 Unigene Cluster for SYPL2: Synaptophysin-like 2 Hs.528366 [show with all ESTs]Unigene Representative Sequence: NM_0010407093 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000369872(uc001dxo.2 uc001dxq.2 uc001dxp.3 uc010ovk.2)
ENST00000475497 ENST00000401021
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SYPL2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SYPL2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SYPL2 (NM_001040709) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SYPL2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYPL2 |
Additional cDNA sequence: AB158472.1 AK095168.1 AK289513.1 AK293082.1 AK301509.1 AK302566.1 AY358862.1 BC110407.1 BC113102.1 BC113103.1 2 DOTS entries: DT.75101019 DT.97796131 24/31 AceView cDNA sequences (see all 31): AW611858 AY358862 BM561680 BX093337 BM021534 AW196238 AW590829 AK131459 F35765 CK904347 BF791734 BX282727 AI089671 AI476332 BX500858 AK095168 T11509 AW271199 AA442429 AA946911 AW242844 AI983207 AI146436 BF982139
GeneLoc Exon Structure
|
Expression
for SYPL2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SYPL2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See SYPL2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SYPL2
SOURCE GeneReport for Unigene cluster: Hs.528366
SABiosciences Custom PCR Arrays for SYPL2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SYPL2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SYPL2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SYPL2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SYPL2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYPL2 |
Orthologs
for SYPL2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for SYPL2 gene from 3/14 species (see all 14) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
LOC1008589201 |
synaptophysin-like protein 2-like |
74.07(n)
73.78(a) |
|
100858920 XM_003643372.1 XP_003643420.1 |
lizard
(Anolis carolinensis) |
Reptilia |
SYPL26 |
-- |
69(a) |
1 ↔ 1 |
4(105516305-105536216) |
worm
(Caenorhabditis elegans) |
Secernentea |
sph-16 |
SyaptoPHysin family member (sph-1) |
22(a) |
possible ortholog |
IV(8132161-8133678) |
ENSEMBL Gene Tree for SYPL2 (if available)
TreeFam Gene Tree for SYPL2 (if available) |
Paralogs
for SYPL2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SYPL2 gene
- SYNPR2 SYPL12 SYP2
4 SIMAP similar genes for SYPL2 using alignment to 3 protein entries: SYPL2_HUMAN (see all proteins):SYPL SYPL1 SYNPR SYP
SYPL2 for paralogs About GeneDecksing
|
Genomic Variants
for SYPL2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SYPL2 (110009100 - 110024764 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SYPL2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SYPL2 |
|
Disorders
/ Diseases
for SYPL2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SYPL2 for disorders About GeneDecksing
3  diseases for SYPL2: About MalaCardsmajor depressive disorder tetanus kidney disease
Export disorders for SYPL2 gene to outside databases
|
Publications
for SYPL2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SYPL2 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with SYPL2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Mitsugumin 29 is transcriptionally induced in senile plaque- associated astrocytes. (PubMed id 22290180)1, 2 Satoh K.... Yamada T. (2012)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 3 Clark H.F.... Gray A.M. (2003)
- Genome-wide association study of recurrent early-onse t major depressive disorder. (PubMed id 20125088)1 Shi J....Levinson D.F. (2010)
- New loci associated with kidney function and chronic kidney disease. (PubMed id 20383146)1 KAPttgen A....Fox C.S. (2010)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Muscle aging is associated with compromised Ca2+ spark signaling and segregated intracellular Ca2+ release. (PubMed id 16943181)9 Weisleder N....Ma J. (2006)
- Dysfunction of store-operated calcium channel in muscle cells lacking mg29. (PubMed id 11988740)9 Pan Z....Ma J. (2002)
|
External Searches for SYPL2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SYPL2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SYPL2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SYPL2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SYPL2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SYPL2 gene:
Search GeneIP for patents involving SYPL2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SYPL2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for SYPL2 | | OriGene shRNA RFP for SYPL2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SYPL2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SYPL2 | | | OriGene Protein Over-expression Lysate for SYPL2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SYPL2 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SYPL2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SYPL2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SYPL2 | | OriGene Custom Protein Services for SYPL2 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SYPL2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SYPL2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SYPL2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SYPL2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SYPL2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SYPL2 |
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 |  |  |  | |
| | | | Search Tocris compounds for SYPL2 |
| |  |  |  |  | | | | |
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 | | | SYPL2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYPL2 |
|  |  |  | | | | ThermoFisher Antibodies for SYPL2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYPL2 |
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