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SYPL1 Gene

protein-coding   GIFtS: 51
GCID: GC07M105730

Synaptophysin-Like 1

(Previous name: synaptophysin-like protein)
(Previous symbol: SYPL)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Synaptophysin-Like 11 2     pantophysin2
SYPL1 2 3     Synaptophysin-Like Protein 12
Synaptophysin-Like Protein1     Pantophysin3
H-SP12     

External Ids:    HGNC: 115071   Entrez Gene: 68562   Ensembl: ENSG000000082827   UniProtKB: Q165633   

Export aliases for SYPL1 gene to outside databases

Previous GC identifers: GC07M105325 GC07M105518 GC07M100090


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SYPL1 Gene:
SYPL1 (synaptophysin-like 1) is a protein-coding gene. Diseases associated with SYPL1 include neuronitis. GO annotations related to this gene include transporter activity. An important paralog of this gene is SYNPR.

Gene Wiki entry for SYPL1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SYPL1 gene promoter:
         Nkx3-1   Nkx3-1 v2   Nkx3-1 v4   Nkx3-1 v3   Nkx3-1 v1   STAT5A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SYPL1 promoter sequence
   Search Chromatin IP Primers for SYPL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SYPL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22.3   Ensembl cytogenetic band:  7q22.3   HGNC cytogenetic band: 7q22.2

SYPL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SYPL1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M105730:  view genomic region     (about GC identifiers)

Start:
105,730,949 bp from pter      End:
105,753,057 bp from pter
Size:
22,109 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 105,091,975-105,114,065     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SYPL1_HUMAN, Q16563 (See protein sequence)
Recommended Name: Synaptophysin-like protein 1  
Size: 259 amino acids; 28565 Da
Secondary accessions: A4D0R2 Q96AR8
Alternative splicing: 2 isoforms:  Q16563-1   Q16563-2   

Explore the universe of human proteins at neXtProt for SYPL1: NX_Q16563

Explore proteomics data for SYPL1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn71, Asn212
  • Modification sites at PhosphoSitePlus

  • See SYPL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_006745.1  NP_874384.1  

    ENSEMBL proteins: 
     ENSP00000388336   ENSP00000011473   ENSP00000417473   ENSP00000419070  

    SYPL1 Human Recombinant Protein Products:

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    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

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    SYPL1 Assay Products:

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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR001285 Synaptophysin/porin
     IPR008253 Marvel

    Graphical View of Domain Structure for InterPro Entry Q16563

    ProtoNet protein and cluster: Q16563

    1 Blocks protein domain: IPB008253 Marvel

    UniProtKB/Swiss-Prot: SYPL1_HUMAN, Q16563
    Similarity: Belongs to the synaptophysin/synaptobrevin family
    Similarity: Contains 1 MARVEL domain


    SYPL1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity IEA--
         
    SYPL1 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Sypl (no phenotypes)

    SYPL1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SYPL1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SYPL1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SYPL1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SYPL1

    miRNA
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    miRTarBase miRNAs that target SYPL1:
    hsa-mir-16-5p (MIRT031908), hsa-mir-18a-5p (MIRT031347), hsa-mir-124-3p (MIRT004119), hsa-mir-155-5p (MIRT001497), hsa-mir-1 (MIRT023943), hsa-mir-744-5p (MIRT037563), hsa-mir-30a-5p (MIRT005203), hsa-mir-9-5p (MIRT021479), hsa-mir-30b-5p (MIRT023449), hsa-mir-615-3p (MIRT039715), hsa-mir-340-5p (MIRT019598)

    Block miRNA regulation of human, mouse, rat SYPL1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SYPL1 (see all 35):
    hsa-miR-607 hsa-miR-199a-3p hsa-miR-15a hsa-miR-485-3p hsa-miR-3653 hsa-miR-30d hsa-miR-218 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidSYPL1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SYPL1
    Predesigned siRNA for gene silencing in human, mouse, rat SYPL1

    Gene Editing
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    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SYPL1 (NM_182715)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SYPL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYPL1

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYPL1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SYPL1_HUMAN, Q16563: Cytoplasmic vesicle membrane; Multi-pass membrane protein (By similarity). Melanosome.
    Note=Cytoplasmic transport vesicles (By similarity). Identified by mass spectrometry in melanosome fractions from
    stage I to stage IV
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral component of plasma membrane TAS8034131
    GO:0008021synaptic vesicle ----
    GO:0016020membrane ----
    GO:0016021integral component of membrane TAS1730063
    GO:0030141secretory granule IEA--

    SYPL1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SYPL1
    Interactions:

        Search GeneGlobe Interaction Network for SYPL1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for SYPL1 (Q165633 ENSP000000114734) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    VAMP2P630273, ENSP000003142144I2D: score=2 STRING: ENSP00000314214
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007268synaptic transmission TAS8034131

    SYPL1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SYPL1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SYPL1 gene (2 alternative transcripts): 
    NM_006754.3  NM_182715.2  

    Unigene Cluster for SYPL1:

    Synaptophysin-like 1
    Hs.80919  [show with all ESTs]
    Unigene Representative Sequence: AK128299
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000455385(uc003vdo.3) ENST00000011473(uc003vdp.3) ENST00000464029
    ENST00000470347 ENST00000460770 ENST00000483448
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SYPL1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SYPL1 (see all 35):
    hsa-miR-607 hsa-miR-199a-3p hsa-miR-15a hsa-miR-485-3p hsa-miR-3653 hsa-miR-30d hsa-miR-218 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidSYPL1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SYPL1
    Predesigned siRNA for gene silencing in human, mouse, rat SYPL1
    Clone
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    OriGene clones in human, mouse for SYPL1 (see all 13)
    OriGene ORF clones in mouse, rat for SYPL1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SYPL1 (NM_182715)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SYPL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYPL1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SYPL1
    OriGene qSTAR qPCR primer pairs in human, mouse for SYPL1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SYPL1
      QuantiTect SYBR Green Assays in human, mouse, rat SYPL1
      QuantiFast Probe-based Assays in human, mouse, rat SYPL1

    Additional mRNA sequence: 

    AK128279.1 AK128299.1 AK292230.1 BC016835.1 BC020938.1 BC061887.1 S72481.1 X61382.1 
    X68194.1 

    21 DOTS entries:

    DT.101984298  DT.100880282  DT.75193648  DT.91778483  DT.121053658  DT.100880280  DT.95357184  DT.95365565 
    DT.97846300  DT.100767573  DT.121053704  DT.100880278  DT.95365566  DT.100880273  DT.100880274  DT.100880281 
    DT.100880284  DT.121053655  DT.121053664  DT.121053694  DT.95365554 

    Selected AceView cDNA sequences (see all 588):

    CD742798 AI168051 AI267782 N28025 BM745665 CB108394 AW963202 AI818079 
    BP351940 AW008573 BI335727 CD513985 CB111264 NM_006754 AA593189 AI431782 
    AI127375 AA830041 BI549567 AL545281 BQ645253 AA813054 BQ439312 BP354169 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SYPL1 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d
    SP1:                    -                 -                                               -     -     -                           
    SP2:                    -                 -                                                                                       
    SP3:                    -                 -                 -                                                                     
    SP4:                                      -                                               -     -     -                           
    SP5:                                      -           -                                                                           


    ECgene alternative splicing isoforms for SYPL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SYPL1 expression in normal human tissues (normalized intensities)      SYPL1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACAAGAATTG
    SYPL1 Expression
    About this image


    SYPL1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 17) fully expand
     
     Blood (Hematopoietic System)
             Mature B-Cells Peripheral Blood
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
     
     Intestine (Gastrointestinal Tract)
     
     Thyroid (Endocrine System)
    SYPL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SYPL1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.80919
        Custom PCR Arrays for SYPL1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYPL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SYPL1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sypl1 , 5 synaptophysin-like protein1, 5 83.91(n)1
    82.24(a)1
      12 (13.87 cM)5
    190271  NM_013635.31  NP_038663.21 
     329538915 
    chicken
    (Gallus gallus)
    Aves SYPL11 synaptophysin-like 1 68.19(n)
    62.56(a)
      417708  NM_001199458.1  NP_001186387.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    --
    58(a)
    54(a)
    1 ↔ many
    1 ↔ many
    GL343276.1(1537655-1547979)
    5(96878479-96895704)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3986462 hypothetical protein LOC398646 76.18(n)    BC043865.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003302381 synaptophysin-like protein 1-like 54.04(n)
    49.79(a)
      100330238  XM_002661341.3  XP_002661387.1 
    worm
    (Caenorhabditis elegans)
    Secernentea sph-16
    Protein SPH-1 (sph-1) mRNA, complete cds
    26(a)
    1 → many
    IV(8132175-8133692) WBGene00004979


    ENSEMBL Gene Tree for SYPL1 (if available)
    TreeFam Gene Tree for SYPL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SYPL1 gene
    SYNPR2  SYP2  SYPL22  
    10 SIMAP similar genes for SYPL1 using alignment to 3 protein entries:     SYPL1_HUMAN (see all proteins):
    SYPL    ZNF74    AURA2    FAM3A    ZNF564    CRCP
    YTHDF3    SYPL2    SYNPR    SYP

    SYPL1 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for SYPL1
    PGOHUM00000236996 PGOHUM00000237826 PGOHUM00000243403


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SYPL1 (see all 437)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1890848751,2
    C--105730462(+) AAAAAA/GGACAG 2 -- ds50010--------
    rs1817578071,2
    --105730589(+) TGAGGC/GACACA 2 -- ds50010--------
    rs1178894311,2
    C,F--105730603(+) GGCAAT/CTTGCC 2 -- ds50011Minor allele frequency- C:0.03NA 120
    rs346163721,2
    C,F--105730623(+) ACAGCT/CAGTAA 2 -- ds50015Minor allele frequency- C:0.45NA EA 246
    rs1764841,2
    C,F,H--105730661(+) CAGTTT/CGGTTG 2 -- ds500116Minor allele frequency- C:0.02NS EA NA WA CSA 776
    rs352777411,2
    C,F--105730685(+) CTTAAG/TCAGGA 2 -- ds50019Minor allele frequency- T:0.42NA WA CSA EA 370
    rs104878291,2
    C,F,H--105730729(-) TGATAT/CACCTT 2 -- ds500117Minor allele frequency- C:0.10NS NA EA WA CSA 788
    rs1860613541,2
    --105730852(+) TAAAAC/TTGTGA 2 -- ut310--------
    rs11313581,2
    C--105730975(-) CAACCA/CATTTA 2 -- ut312Minor allele frequency- C:0.00NA 4
    rs1903527361,2
    --105730988(+) AAAAAG/TATATA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for SYPL1 (105730949 - 105753057 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for SYPL1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv4398CNV Deletion18987735
    esv2734977CNV Deletion23290073
    esv2734978CNV Deletion23290073
    nsv520366CNV Loss19592680
    nsv365599CNV Loss16902084
    esv6202CNV Loss19470904

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SYPL1
    DNA2.0 Custom Variant and Variant Library Synthesis for SYPL1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    1 disease for SYPL1:    About MalaCards
    neuronitis


    SYPL1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SYPL1

    Export disorders for SYPL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SYPL1 gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with SYPL1)
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    1. Expression of the synaptophysin gene family is not restricted to neuronal and neuroendocrine differentiation in rat and human. (PubMed id 8034131)1, 2, 9 Leube R.E. (Differentiation 1994)
    2. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)1, 2 Chi A....Hunt D.F. (J. Proteome Res. 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (Science 2003)
    5. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
    6. Molecular cloning of a cDNA encoding a novel protein related to the neuronal vesicle protein synaptophysin. (PubMed id 1730063)1, 2 Zhong C.Z.... Runge M.S. (Biochim. Biophys. Acta 1992)
    7. Pantophysin is a phosphoprotein component of adipocyte transport vesicles and associates with GLUT4-containing vesicles. (PubMed id 10636906)1, 9 Brooks C.C....Cheatham B. (J. Biol. Chem. 2000)
    8. Pantophysin is a ubiquitously expressed synaptophysin homologue and defines constitutive transport vesicles. (PubMed id 8707851)1, 9 Haass N.K....Leube R.E. (J. Cell Biol. 1996)
    9. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6856 HGNC: 11507 AceView: SYPL Ensembl:ENSG00000008282 euGenes: HUgn6856
    ECgene: SYPL1 H-InvDB: SYPL1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SYPL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SYPL1 gene:
    Search GeneIP for patents involving SYPL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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