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Aliases for SYPL1 Gene

Aliases for SYPL1 Gene

  • Synaptophysin Like 1 2 3 5
  • Pantophysin 2 3 4
  • SYPL 3 4
  • Synaptophysin-Like Protein 1 3
  • Synaptophysin-Like Protein 2
  • Synaptophysin-Like 1 2
  • H-SP1 3

External Ids for SYPL1 Gene

Previous HGNC Symbols for SYPL1 Gene

  • SYPL

Previous GeneCards Identifiers for SYPL1 Gene

  • GC07M105325
  • GC07M105518
  • GC07M105730
  • GC07M100090

Summaries for SYPL1 Gene

GeneCards Summary for SYPL1 Gene

SYPL1 (Synaptophysin Like 1) is a Protein Coding gene. GO annotations related to this gene include transporter activity. An important paralog of this gene is SYP.

Gene Wiki entry for SYPL1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYPL1 Gene

Genomics for SYPL1 Gene

Regulatory Elements for SYPL1 Gene

Enhancers for SYPL1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G106056 1.9 FANTOM5 Ensembl ENCODE dbSUPER 21.7 +50.8 50837 10.1 HDGF PKNOX1 MLX ARNT ARID4B SIN3A ZNF2 YY1 CBX5 ZNF143 SYPL1 GC07M106081 GC07P106037
GH07G106068 2 FANTOM5 Ensembl ENCODE dbSUPER 13 +41.0 41006 6.9 HDGF PKNOX1 FOXA2 CREB3L1 ARNT ARID4B SIN3A YBX1 FEZF1 ZBTB7B SYPL1 RINT1 DCAF13P1 GC07M106081 GC07P106037
GH07G106050 1.1 ENCODE dbSUPER 16.7 +62.0 61986 1.1 ARID4B BMI1 ZNF2 RAD21 ZNF335 FOS THAP11 ZNF362 JUNB CEBPB SYPL1 GC07P106037 GC07M106081
GH07G106153 1.1 Ensembl ENCODE 12.8 -41.3 -41292 0.7 RB1 BMI1 ZNF2 RAD21 GATA2 ZNF143 FOS ZNF654 CEBPB REST SYPL1 GC07P106126 GC07P106209
GH07G106076 0.7 dbSUPER 18.6 +36.3 36251 2.0 PKNOX1 GTF2E2 FEZF1 ZSCAN5C IKZF2 HES1 L3MBTL2 RNF2 BHLHE40 TBX21 SYPL1 GC07M106081 GC07P106037
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SYPL1 on UCSC Golden Path with GeneCards custom track

Promoters for SYPL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000216418 1047 2401 HDGF ARNT AGO1 ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207 KLF13

Genomic Location for SYPL1 Gene

Chromosome:
7
Start:
106,090,368 bp from pter
End:
106,112,647 bp from pter
Size:
22,280 bases
Orientation:
Minus strand

Genomic View for SYPL1 Gene

Genes around SYPL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SYPL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SYPL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYPL1 Gene

Proteins for SYPL1 Gene

  • Protein details for SYPL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16563-SYPL1_HUMAN
    Recommended name:
    Synaptophysin-like protein 1
    Protein Accession:
    Q16563
    Secondary Accessions:
    • A4D0R2
    • Q96AR8

    Protein attributes for SYPL1 Gene

    Size:
    259 amino acids
    Molecular mass:
    28565 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SYPL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SYPL1 Gene

Post-translational modifications for SYPL1 Gene

  • Glycosylation at Asn71 and posLast=212212
  • Modification sites at PhosphoSitePlus

Other Protein References for SYPL1 Gene

No data available for DME Specific Peptides for SYPL1 Gene

Domains & Families for SYPL1 Gene

Protein Domains for SYPL1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SYPL1 Gene

Graphical View of Domain Structure for InterPro Entry

Q16563

UniProtKB/Swiss-Prot:

SYPL1_HUMAN :
  • Belongs to the synaptophysin/synaptobrevin family.
Family:
  • Belongs to the synaptophysin/synaptobrevin family.
genes like me logo Genes that share domains with SYPL1: view

No data available for Gene Families for SYPL1 Gene

Function for SYPL1 Gene

Gene Ontology (GO) - Molecular Function for SYPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity IEA --
genes like me logo Genes that share ontologies with SYPL1: view
genes like me logo Genes that share phenotypes with SYPL1: view

Animal Models for SYPL1 Gene

MGI Knock Outs for SYPL1:
  • Sypl tm1b(KOMP)Wtsi

Animal Model Products

  • Taconic Biosciences Mouse Models for SYPL1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SYPL1 Gene

Localization for SYPL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYPL1 Gene

Cytoplasmic vesicle membrane; Multi-pass membrane protein. Melanosome. Note=Cytoplasmic transport vesicles (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SYPL1 gene
Compartment Confidence
plasma membrane 5
extracellular 5

Gene Ontology (GO) - Cellular Components for SYPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 8034131
GO:0008021 synaptic vesicle IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane TAS,IEA 1730063
GO:0030141 secretory granule IEA --
genes like me logo Genes that share ontologies with SYPL1: view

Pathways & Interactions for SYPL1 Gene

SuperPathways for SYPL1 Gene

No Data Available

Interacting Proteins for SYPL1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000011473%0d%0a9606.ENSP00000314214%0d%0a
Selected Interacting proteins: Q16563-SYPL1_HUMAN ENSP00000011473 for SYPL1 Gene via IID STRING

Gene Ontology (GO) - Biological Process for SYPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0007268 chemical synaptic transmission TAS 8034131
genes like me logo Genes that share ontologies with SYPL1: view

No data available for Pathways by source and SIGNOR curated interactions for SYPL1 Gene

Transcripts for SYPL1 Gene

Unigene Clusters for SYPL1 Gene

Synaptophysin-like 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SYPL1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d
SP1: - - - - -
SP2: - -
SP3: - - -
SP4: - - - -
SP5: - -
SP6: -
SP7:
SP8: -

Relevant External Links for SYPL1 Gene

GeneLoc Exon Structure for
SYPL1
ECgene alternative splicing isoforms for
SYPL1

Expression for SYPL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SYPL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SYPL1 Gene

This gene is overexpressed in Nasal epithelium (13.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SYPL1 Gene



Protein tissue co-expression partners for SYPL1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SYPL1 Gene:

SYPL1

SOURCE GeneReport for Unigene cluster for SYPL1 Gene:

Hs.80919

Evidence on tissue expression from TISSUES for SYPL1 Gene

  • Nervous system(4.9)
  • Lung(4.5)
  • Liver(4.4)
  • Skin(4.3)
  • Blood(4.1)
  • Kidney(3.8)
  • Intestine(2.4)
genes like me logo Genes that share expression patterns with SYPL1: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SYPL1 Gene

Orthologs for SYPL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SYPL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SYPL1 34 35
  • 99.45 (n)
dog
(Canis familiaris)
Mammalia SYPL1 34 35
  • 87.58 (n)
rat
(Rattus norvegicus)
Mammalia Sypl1 34
  • 85.14 (n)
mouse
(Mus musculus)
Mammalia Sypl 34 16 35
  • 83.91 (n)
cow
(Bos Taurus)
Mammalia SYPL1 35
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SYPL1 35
  • 68 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SYPL1 35
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves SYPL1 34 35
  • 68.19 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 58 (a)
OneToMany
-- 35
  • 54 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia sypl1 34
  • 63.32 (n)
MGC76143 34
African clawed frog
(Xenopus laevis)
Amphibia LOC398646 34
zebrafish
(Danio rerio)
Actinopterygii LOC100330238 34
  • 54.04 (n)
sypl1 35
  • 46 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea sph-1 35
  • 26 (a)
OneToMany
Species where no ortholog for SYPL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SYPL1 Gene

ENSEMBL:
Gene Tree for SYPL1 (if available)
TreeFam:
Gene Tree for SYPL1 (if available)

Paralogs for SYPL1 Gene

Paralogs for SYPL1 Gene

(10) SIMAP similar genes for SYPL1 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for SYPL1 Gene

genes like me logo Genes that share paralogs with SYPL1: view

Variants for SYPL1 Gene

Sequence variations from dbSNP and Humsavar for SYPL1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000016267 -- 106,094,508(+) AAAAC(C/T)GTAGC intron-variant
rs1000316860 -- 106,096,923(+) TATTT(-/A)AAAAA intron-variant
rs1000450440 -- 106,089,883(+) ATATT(C/T)TGAGA downstream-variant-500B
rs1000618625 -- 106,095,645(+) CTGCA(A/C)CCAGT intron-variant
rs1000691068 -- 106,096,079(+) AGATT(A/T)TTCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SYPL1 Gene

Variant ID Type Subtype PubMed ID
dgv3639n106 CNV deletion 24896259
esv2734977 CNV deletion 23290073
esv2734978 CNV deletion 23290073
esv3277051 CNV deletion 24192839
esv3542231 CNV deletion 23714750
esv3614438 CNV loss 21293372
esv4398 CNV loss 18987735
esv6202 CNV loss 19470904
nsv1027213 CNV gain 25217958
nsv1075988 CNV deletion 25765185
nsv1145958 CNV deletion 26484159
nsv365599 CNV deletion 16902084
nsv520366 CNV loss 19592680

Variation tolerance for SYPL1 Gene

Residual Variation Intolerance Score: 63.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.79; 16.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SYPL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SYPL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SYPL1 Gene

Disorders for SYPL1 Gene

Relevant External Links for SYPL1

Genetic Association Database (GAD)
SYPL1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SYPL1

No disorders were found for SYPL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SYPL1 Gene

Publications for SYPL1 Gene

  1. Expression of the synaptophysin gene family is not restricted to neuronal and neuroendocrine differentiation in rat and human. (PMID: 8034131) Leube R.E. (Differentiation 1994) 3 4 22 64
  2. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PMID: 17081065) Chi A. … Hunt D.F. (J. Proteome Res. 2006) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4 64
  5. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4 64

Products for SYPL1 Gene

Sources for SYPL1 Gene

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