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Aliases for SYPL1 Gene

Aliases for SYPL1 Gene

  • Synaptophysin-Like 1 2 3
  • Pantophysin 3 4
  • SYPL 3 4
  • Synaptophysin-Like Protein 1 3
  • Synaptophysin-Like Protein 2
  • H-SP1 3

External Ids for SYPL1 Gene

Previous HGNC Symbols for SYPL1 Gene

  • SYPL

Previous GeneCards Identifiers for SYPL1 Gene

  • GC07M105325
  • GC07M105518
  • GC07M105730
  • GC07M100090

Summaries for SYPL1 Gene

GeneCards Summary for SYPL1 Gene

SYPL1 (Synaptophysin-Like 1) is a Protein Coding gene. GO annotations related to this gene include transporter activity. An important paralog of this gene is SYNPR.

Gene Wiki entry for SYPL1 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYPL1 Gene

Genomics for SYPL1 Gene

Regulatory Elements for SYPL1 Gene

Genomic Location for SYPL1 Gene

106,090,368 bp from pter
106,112,647 bp from pter
22,280 bases
Minus strand

Genomic View for SYPL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SYPL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYPL1 Gene

Proteins for SYPL1 Gene

  • Protein details for SYPL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Synaptophysin-like protein 1
    Protein Accession:
    Secondary Accessions:
    • A4D0R2
    • Q96AR8

    Protein attributes for SYPL1 Gene

    259 amino acids
    Molecular mass:
    28565 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SYPL1 Gene


neXtProt entry for SYPL1 Gene

Proteomics data for SYPL1 Gene at MOPED

Post-translational modifications for SYPL1 Gene

  • Glycosylation at Asn71 and Asn212
  • Modification sites at PhosphoSitePlus

Other Protein References for SYPL1 Gene

No data available for DME Specific Peptides for SYPL1 Gene

Domains for SYPL1 Gene

Protein Domains for SYPL1 Gene


Suggested Antigen Peptide Sequences for SYPL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 MARVEL domain.
  • Belongs to the synaptophysin/synaptobrevin family.
  • Contains 1 MARVEL domain.
  • Belongs to the synaptophysin/synaptobrevin family.
genes like me logo Genes that share domains with SYPL1: view

No data available for Gene Families for SYPL1 Gene

Function for SYPL1 Gene

Gene Ontology (GO) - Molecular Function for SYPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity IEA --
genes like me logo Genes that share ontologies with SYPL1: view

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SYPL1

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for SYPL1 Gene

Localization for SYPL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYPL1 Gene

Cytoplasmic vesicle membrane; Multi-pass membrane protein. Melanosome. Note=Cytoplasmic transport vesicles (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for SYPL1 Gene COMPARTMENTS Subcellular localization image for SYPL1 gene
Compartment Confidence
plasma membrane 4
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SYPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 8034131
GO:0008021 synaptic vesicle IEA --
GO:0016020 membrane --
GO:0016021 integral component of membrane TAS 1730063
GO:0030141 secretory granule IEA --
genes like me logo Genes that share ontologies with SYPL1: view

Pathways for SYPL1 Gene

SuperPathways for SYPL1 Gene

No Data Available

Interacting Proteins for SYPL1 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000011473 Q16563-SYPL1_HUMAN for SYPL1 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for SYPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0007268 synaptic transmission TAS 8034131
genes like me logo Genes that share ontologies with SYPL1: view

No data available for Pathways by source for SYPL1 Gene

Transcripts for SYPL1 Gene

Unigene Clusters for SYPL1 Gene

Synaptophysin-like 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SYPL1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SYPL1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d
SP1: - - - - -
SP2: - -
SP3: - - -
SP4: - - - -
SP5: - -
SP6: -
SP8: -

Relevant External Links for SYPL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SYPL1 Gene

mRNA expression in normal human tissues for SYPL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for SYPL1 Gene

This gene is overexpressed in Nasal epithelium (13.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SYPL1 Gene

SOURCE GeneReport for Unigene cluster for SYPL1 Gene Hs.80919

genes like me logo Genes that share expressions with SYPL1: view

Expression partners for SYPL1 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SYPL1 Gene

Orthologs for SYPL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SYPL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia SYPL1 35
  • 87.58 (n)
  • 86.82 (a)
SYPL1 36
  • 85 (a)
(Mus musculus)
Mammalia Sypl 35
  • 83.91 (n)
  • 82.24 (a)
Sypl 16
Sypl 36
  • 81 (a)
(Pan troglodytes)
Mammalia SYPL1 35
  • 99.45 (n)
  • 99.59 (a)
SYPL1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Sypl1 35
  • 85.14 (n)
  • 82.56 (a)
(Bos Taurus)
Mammalia SYPL1 36
  • 79 (a)
(Monodelphis domestica)
Mammalia SYPL1 36
  • 63 (a)
(Ornithorhynchus anatinus)
Mammalia SYPL1 36
  • 68 (a)
(Gallus gallus)
Aves SYPL1 35
  • 68.19 (n)
  • 62.56 (a)
SYPL1 36
  • 58 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 54 (a)
-- 36
  • 58 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76143 35
sypl1 35
  • 63.32 (n)
  • 57.64 (a)
African clawed frog
(Xenopus laevis)
Amphibia LOC398646 35
(Danio rerio)
Actinopterygii LOC100330238 35
  • 54.04 (n)
  • 49.79 (a)
sypl1 36
  • 46 (a)
(Caenorhabditis elegans)
Secernentea sph-1 36
  • 26 (a)
Species with no ortholog for SYPL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SYPL1 Gene

Gene Tree for SYPL1 (if available)
Gene Tree for SYPL1 (if available)

Paralogs for SYPL1 Gene

Paralogs for SYPL1 Gene

(10) SIMAP similar genes for SYPL1 Gene using alignment to 3 proteins: Pseudogenes for SYPL1 Gene

genes like me logo Genes that share paralogs with SYPL1: view

Variants for SYPL1 Gene

Sequence variations from dbSNP and Humsavar for SYPL1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs59216 -- 106,099,563(+) TTTTT(C/T)TTTGA intron-variant
rs59217 -- 106,099,494(+) TCAAG(A/C/G/T)GATCC intron-variant
rs176484 -- 106,090,215(+) CAGTT(C/T)GGTTG downstream-variant-500B
rs176485 -- 106,091,983(+) ACTTA(A/C/T)AAAAA intron-variant
rs176486 -- 106,093,173(+) GAACA(A/G)TTAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SYPL1 Gene

Variant ID Type Subtype PubMed ID
nsv520366 CNV Loss 19592680
esv2734977 CNV Deletion 23290073
esv4398 CNV Deletion 18987735
esv6202 CNV Loss 19470904
esv2734978 CNV Deletion 23290073
nsv365599 CNV Loss 16902084

Relevant External Links for SYPL1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SYPL1 Gene

Disorders for SYPL1 Gene

Relevant External Links for SYPL1

Genetic Association Database (GAD)

No disorders were found for SYPL1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for SYPL1 Gene

Publications for SYPL1 Gene

  1. Expression of the synaptophysin gene family is not restricted to neuronal and neuroendocrine differentiation in rat and human. (PMID: 8034131) Leube R.E. (Differentiation 1994) 3 4 23
  2. Pantophysin is a ubiquitously expressed synaptophysin homologue and defines constitutive transport vesicles. (PMID: 8707851) Haass N.K. … Leube R.E. (J. Cell Biol. 1996) 3 23
  3. Molecular cloning of a cDNA encoding a novel protein related to the neuronal vesicle protein synaptophysin. (PMID: 1730063) Zhong C.Z. … Runge M.S. (Biochim. Biophys. Acta 1992) 3 4
  4. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4
  5. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4

Products for SYPL1 Gene

Sources for SYPL1 Gene

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