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Aliases for SYNRG Gene

Aliases for SYNRG Gene

  • Synergin Gamma 2 3 5
  • Gamma-Synergin 2 3 4
  • Adaptor-Related Protein Complex 1 Gamma Subunit-Binding Protein 1 2 3
  • AP1 Gamma Subunit Binding Protein 1 2 3
  • AP1 Subunit Gamma-Binding Protein 1 3 4
  • AP1GBP1 3 4
  • SYNG 3 4

External Ids for SYNRG Gene

Previous HGNC Symbols for SYNRG Gene

  • AP1GBP1

Previous GeneCards Identifiers for SYNRG Gene

  • GC17M032953
  • GC17M035874
  • GC17M031812

Summaries for SYNRG Gene

Entrez Gene Summary for SYNRG Gene

  • This gene encodes a protein that interacts with the gamma subunit of AP1 clathrin-adaptor complex. The AP1 complex is located at the trans-Golgi network and associates specific proteins with clathrin-coated vesicles. This encoded protein may act to connect the AP1 complex to other proteins. Alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for SYNRG Gene

SYNRG (Synergin Gamma) is a Protein Coding gene. Diseases associated with SYNRG include Chromosome 17Q12 Deletion Syndrome. Gene Ontology (GO) annotations related to this gene include calcium ion binding.

UniProtKB/Swiss-Prot for SYNRG Gene

  • May play a role in endocytosis and/or membrane trafficking at the trans-Golgi network (TGN). May act by linking the adapter protein complex AP-1 to other proteins.

Gene Wiki entry for SYNRG Gene

Additional gene information for SYNRG Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYNRG Gene

Genomics for SYNRG Gene

GeneHancer (GH) Regulatory Elements for SYNRG Gene

Promoters and enhancers for SYNRG Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I037603 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 575.8 +2.1 2073 7.2 HDGF PKNOX1 CLOCK SMAD1 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 SYNRG DDX52 ENSG00000277688 GC17P037579
GH17I037647 Enhancer 1 FANTOM5 Ensembl ENCODE 15.2 -39.0 -39043 1.8 ELF3 ZNF121 JUND SAP130 RNF2 POLR2A SMARCA4 JUN ENSG00000274244 LOC105371756 SYNRG HNF1B DDX52 ENSG00000277501
GH17I037486 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 4.9 +118.7 118736 8.2 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 DUSP14 GC17M037483 TADA2A ACACA DDX52 SYNRG MRPL45 PIR41271
GH17I037405 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 4.3 +202.7 202660 3.2 HDGF SMAD1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 POLR2B ZNF766 TADA2A ENSG00000273965 ACACA DUSP14 DDX52 SYNRG
GH17I037482 Enhancer 1.3 Ensembl ENCODE dbSUPER 4.8 +126.0 126000 1.5 HDAC1 ZNF76 BATF ZNF335 GLIS2 ZNF366 ZNF391 FOS ATF7 EGR2 GC17P037485 TADA2A ACACA SYNRG GC17M037483 GC17M037452
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SYNRG on UCSC Golden Path with GeneCards custom track

Genomic Locations for SYNRG Gene

Genomic Locations for SYNRG Gene
94,700 bases
Minus strand

Genomic View for SYNRG Gene

Genes around SYNRG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SYNRG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SYNRG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYNRG Gene

Proteins for SYNRG Gene

  • Protein details for SYNRG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Synergin gamma
    Protein Accession:
    Secondary Accessions:
    • A8MWU4
    • B7ZKZ2
    • B7ZKZ3
    • Q17RI2
    • Q5BKU5
    • Q6ZT17

    Protein attributes for SYNRG Gene

    1314 amino acids
    Molecular mass:
    140654 Da
    Quaternary structure:
    • Interacts with SCAMP1 via its EH-domain (By similarity). Interacts with GGA1, GGA2 and GGA3. Interacts with the AP1G1 and AP1G2 subunits of the adapter protein complexes AP-1.
    • Sequence=AK126988; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SYNRG Gene

    Alternative splice isoforms for SYNRG Gene

neXtProt entry for SYNRG Gene

Post-translational modifications for SYNRG Gene

  • Ubiquitination at isoforms=3, 4, 5, 7, 8907

No data available for DME Specific Peptides for SYNRG Gene

Domains & Families for SYNRG Gene

Gene Families for SYNRG Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SYNRG Gene

Suggested Antigen Peptide Sequences for SYNRG Gene

Graphical View of Domain Structure for InterPro Entry



  • The DFXDF motifs mediate the interaction with gamma-appendage subunits AP1G1 and AP1G2.
  • The DFXDF motifs mediate the interaction with gamma-appendage subunits AP1G1 and AP1G2.
genes like me logo Genes that share domains with SYNRG: view

Function for SYNRG Gene

Molecular function for SYNRG Gene

UniProtKB/Swiss-Prot Function:
May play a role in endocytosis and/or membrane trafficking at the trans-Golgi network (TGN). May act by linking the adapter protein complex AP-1 to other proteins.

Phenotypes From GWAS Catalog for SYNRG Gene

Gene Ontology (GO) - Molecular Function for SYNRG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SYNRG: view
genes like me logo Genes that share phenotypes with SYNRG: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SYNRG Gene

Localization for SYNRG Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYNRG Gene

Cytoplasm. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Note=Associates with membranes via the adapter protein complex AP-1. Colocalizes with AP1G1 (By similarity). {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SYNRG gene
Compartment Confidence
golgi apparatus 5
nucleus 4
cytosol 3
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SYNRG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 10477754
GO:0005794 Golgi apparatus TAS 10477754
GO:0016020 membrane IEA --
GO:0030121 AP-1 adaptor complex TAS 10477754
genes like me logo Genes that share ontologies with SYNRG: view

Pathways & Interactions for SYNRG Gene

SuperPathways for SYNRG Gene

No Data Available

Gene Ontology (GO) - Biological Process for SYNRG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006886 intracellular protein transport TAS 10477754
GO:0006897 endocytosis IEA --
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with SYNRG: view

No data available for Pathways by source and SIGNOR curated interactions for SYNRG Gene

Drugs & Compounds for SYNRG Gene

(1) Drugs for SYNRG Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with SYNRG: view

Transcripts for SYNRG Gene

Unigene Clusters for SYNRG Gene

Synergin, gamma:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SYNRG Gene

No ASD Table

Relevant External Links for SYNRG Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SYNRG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SYNRG Gene

Protein differential expression in normal tissues from HIPED for SYNRG Gene

This gene is overexpressed in Adrenal (23.6) and Peripheral blood mononuclear cells (11.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SYNRG Gene

Protein tissue co-expression partners for SYNRG Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SYNRG Gene:


SOURCE GeneReport for Unigene cluster for SYNRG Gene:


Evidence on tissue expression from TISSUES for SYNRG Gene

  • Nervous system(4.7)
  • Blood(4.2)
  • Liver(4.2)
  • Lung(2.6)
genes like me logo Genes that share expression patterns with SYNRG: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SYNRG Gene

Orthologs for SYNRG Gene

This gene was present in the common ancestor of chordates.

Orthologs for SYNRG Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SYNRG 33
  • 99.67 (n)
(Canis familiaris)
Mammalia SYNRG 33
  • 90.16 (n)
(Bos Taurus)
Mammalia SYNRG 33
  • 87.61 (n)
(Rattus norvegicus)
Mammalia Synrg 33
  • 82.45 (n)
(Mus musculus)
Mammalia Synrg 33 16
  • 81.57 (n)
(Gallus gallus)
Aves SYNRG 33
  • 74.98 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia synrg 33
  • 61.08 (n)
(Danio rerio)
Actinopterygii synrg 33
  • 63.04 (n)
Species where no ortholog for SYNRG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SYNRG Gene

Gene Tree for SYNRG (if available)
Gene Tree for SYNRG (if available)

Paralogs for SYNRG Gene

No data available for Paralogs for SYNRG Gene

Variants for SYNRG Gene

Sequence variations from dbSNP and Humsavar for SYNRG Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000007762 -- 37,560,693(-) A/G intron_variant
rs1000042046 -- 37,554,529(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000053003 -- 37,605,395(-) G/A intron_variant
rs1000059894 -- 37,514,601(-) C/G downstream_transcript_variant
rs1000113983 -- 37,559,745(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SYNRG Gene

Variant ID Type Subtype PubMed ID
esv2657174 CNV deletion 23128226
esv3307133 CNV mobile element insertion 20981092
esv3310127 CNV mobile element insertion 20981092
esv3373858 CNV insertion 20981092
esv3374090 CNV insertion 20981092
esv3399729 CNV insertion 20981092
esv3640494 CNV gain 21293372
esv3640500 CNV loss 21293372
nsv827979 CNV loss 20364138
nsv833431 CNV gain 17160897

Variation tolerance for SYNRG Gene

Residual Variation Intolerance Score: 21.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.83; 89.61% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SYNRG Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SYNRG Gene

Disorders for SYNRG Gene

MalaCards: The human disease database

(1) MalaCards diseases for SYNRG Gene - From: DISEASES

Disorder Aliases PubMed IDs
chromosome 17q12 deletion syndrome
  • 17q12 microdeletion syndrome
- elite association - COSMIC cancer census association via MalaCards
Search SYNRG in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SYNRG

genes like me logo Genes that share disorders with SYNRG: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SYNRG Gene

Publications for SYNRG Gene

  1. EpsinR: an AP1/clathrin interacting protein involved in vesicle trafficking. (PMID: 12538641) Mills IG … McMahon HT (The Journal of cell biology 2003) 3 4 22 58
  2. Gamma-synergin: an EH domain-containing protein that interacts with gamma-adaptin. (PMID: 10477754) Page LJ … Robinson MS (The Journal of cell biology 1999) 2 3 4 58
  3. Aftiphilin and gamma-synergin are required for secretagogue sensitivity of Weibel-Palade bodies in endothelial cells. (PMID: 18815278) Lui-Roberts WW … Cutler DF (Molecular biology of the cell 2008) 3 22 58
  4. The aftiphilin/p200/gamma-synergin complex. (PMID: 15758025) Hirst J … Robinson MS (Molecular biology of the cell 2005) 3 22 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for SYNRG Gene

Sources for SYNRG Gene

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