Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SYNRG Gene

protein-coding   GIFtS: 50
GCID: GC17M035874

Synergin, Gamma

(Previous name: AP1 gamma subunit binding protein 1)
(Previous symbol: AP1GBP1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Synergin, Gamma1 2     gamma-synergin1 2
AP1GBP11 2 3 5     AP1 Subunit Gamma-Binding Protein 12 3
SYNG2 3 5     Synergin Gamma2
AP1 Gamma Subunit Binding Protein 11 2     Gamma-synergin3
Adaptor-Related Protein Complex 1 Gamma Subunit-Binding Protein 11 2     

External Ids:    HGNC: 5571   Entrez Gene: 112762   Ensembl: ENSG000000061147   OMIM: 6072915   UniProtKB: Q9UMZ23   

Export aliases for SYNRG gene to outside databases

Previous GC identifers: GC17M032953 GC17M031812


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for SYNRG Gene:
This gene encodes a protein that interacts with the gamma subunit of AP1 clathrin-adaptor complex. The AP1 complex
is located at the trans-Golgi network and associates specific proteins with clathrin-coated vesicles. This
encoded protein may act to connect the AP1 complex to other proteins. Alternatively spliced transcript variants
that encode different isoforms have been described for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for SYNRG Gene:
SYNRG (synergin, gamma) is a protein-coding gene. Diseases associated with SYNRG include gastroenteritis, and ovarian cancer. GO annotations related to this gene include calcium ion binding.

UniProtKB/Swiss-Prot: SYNRG_HUMAN, Q9UMZ2
Function: May play a role in endocytosis and/or membrane trafficking at the trans-Golgi network (TGN). May act by
linking the adapter protein complex AP-1 to other proteins

Gene Wiki entry for SYNRG (AP1GBP1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000017.11  NT_010783.16  NT_187614.1  NC_018928.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for SYNRG
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSYNRG promoter sequence
   Search Chromatin IP Primers for SYNRG

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SYNRG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q12   Ensembl cytogenetic band:  17q12   HGNC cytogenetic band: 17q12

SYNRG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SYNRG gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M035874:  view genomic region     (about GC identifiers)

Start:
35,874,900 bp from pter      End:
35,969,544 bp from pter
Size:
94,645 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: SYNRG_HUMAN, Q9UMZ2 (See protein sequence)
Recommended Name: Synergin gamma  
Size: 1314 amino acids; 140654 Da
Subunit: Interacts with SCAMP1 via its EH-domain (By similarity). Interacts with GGA1, GGA2 and GGA3. Interacts
with the AP1G1 and AP1G2 subunits of the adapter protein complexes AP-1
Sequence caution: Sequence=AK126988; Type=Miscellaneous discrepancy; Note=Intron retention;
Secondary accessions: B7ZKZ2 B7ZKZ3 Q17RI2 Q5BKU5 Q6ZT17
Alternative splicing: 5 isoforms:  Q9UMZ2-1   Q9UMZ2-3   Q9UMZ2-4   Q9UMZ2-5   Q9UMZ2-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SYNRG: NX_Q9UMZ2

Explore proteomics data for SYNRG at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys907, Lys928
  • Modification sites at PhosphoSitePlus

  • See SYNRG Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (7 alternative transcripts): 
    NP_001157016.1  NP_001157017.1  NP_001157018.1  NP_001157019.1  NP_009178.3  NP_542117.3  NP_942583.1  

    ENSEMBL proteins: 
     ENSP00000343610   ENSP00000315722   ENSP00000424893   ENSP00000377903   ENSP00000466741  
     ENSP00000468371   ENSP00000468227   ENSP00000467193   ENSP00000466456   ENSP00000005279  

    SYNRG Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for SYNRG
    OriGene Custom MassSpec
    OriGene Custom Protein Services for SYNRG
    GenScript Custom Purified and Recombinant Proteins Services for SYNRG
    Novus Biologicals SYNRG Protein
    Novus Biologicals SYNRG Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    SYNRG Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SYNRG
    Novus Biologicals SYNRG Antibodies
    Abcam antibodies for SYNRG
    Browse Antibodies at Cloud-Clone Corp.
    Search ThermoFisher Antibodies for SYNRG
    LSBio Antibodies in human, mouse, rat for SYNRG

    SYNRG Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SYNRG
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SYNRG
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    2 InterPro protein domains:
     IPR011992 EF-hand-dom_pair
     IPR000261 EPS15_homology

    Graphical View of Domain Structure for InterPro Entry Q9UMZ2

    ProtoNet protein and cluster: Q9UMZ2

    1 Blocks protein domain: IPB000261 EPS15 homology (EH)

    UniProtKB/Swiss-Prot: SYNRG_HUMAN, Q9UMZ2
    Domain: The DFXDF motifs mediate the interaction with gamma-appendage subunits AP1G1 and AP1G2
    Similarity: Contains 1 EH domain


    SYNRG for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SYNRG_HUMAN, Q9UMZ2
    Function: May play a role in endocytosis and/or membrane trafficking at the trans-Golgi network (TGN). May act by
    linking the adapter protein complex AP-1 to other proteins

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding ----
         
    SYNRG for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SYNRG
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SYNRG

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SYNRG
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SYNRG

    miRNA
    Products:
        
    miRTarBase miRNAs that target SYNRG:
    hsa-mir-1180-3p (MIRT035910)

    Block miRNA regulation of human, mouse, rat SYNRG using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SYNRG (see all 80):
    hsa-miR-579 hsa-miR-520e hsa-miR-520f hsa-miR-607 hsa-miR-106a hsa-miR-15a hsa-miR-128 hsa-miR-877*
    SwitchGear 3'UTR luciferase reporter plasmidSYNRG 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SYNRG
    Predesigned siRNA for gene silencing in human, mouse, rat SYNRG

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SYNRG

    Clone
    Products:
         
    OriGene clones in human, mouse for SYNRG (see all 38)
    OriGene ORF clones in mouse, rat for SYNRG
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 7): SYNRG (NM_007247)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SYNRG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYNRG

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SYNRG
    Browse ESI BIO Cell Lines and PureStem Progenitors for SYNRG 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYNRG


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    SYNRG_HUMAN, Q9UMZ2: Cytoplasm (By similarity). Golgi apparatus, trans-Golgi network membrane; Peripheral
    membrane protein (By similarity). Note=Associates with membranes via the adapter protein complex AP-1.
    Colocalizes with AP1G1 (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus4
    cytosol3
    nucleus3

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm TAS10477754
    GO:0005794Golgi apparatus TAS10477754
    GO:0030121AP-1 adaptor complex TAS10477754

    SYNRG for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SYNRG
    Interactions:

        GeneGlobe Interaction Network for SYNRG

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SYNRG (Q9UMZ22, 3 ENSP000000052794) via UniProtKB, MINT, STRING, and/or I2D (see all 92)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GGA1Q9UJY52, 3, ENSP000003413444MINT-14654 I2D: score=3 STRING: ENSP00000341344
    GGA2Q9UJY42, 3, ENSP000003119624MINT-16928 I2D: score=2 STRING: ENSP00000311962
    CCDC91Q7Z6B03, ENSP000003706584I2D: score=1 STRING: ENSP00000370658
    AP1G1O437473, ENSP000003771484I2D: score=2 STRING: ENSP00000377148
    AP1G2O758433, ENSP000003124424I2D: score=1 STRING: ENSP00000312442
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006886intracellular protein transport TAS10477754
    GO:0006897endocytosis IEA--

    SYNRG for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SYNRG

    1 Novoseek inferred chemical compound relationship for SYNRG gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mannose 6-phosphate 69.6 1 14745135 (1)



    SYNRG for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for SYNRG gene (7 alternative transcripts): 
    NM_001163544.2  NM_001163545.2  NM_001163546.2  NM_001163547.2  NM_007247.5  NM_080550.4  NM_198882.2  

    Unigene Cluster for SYNRG:

    Synergin, gamma
    Hs.594647  [show with all ESTs]
    Unigene Representative Sequence: NM_007247
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000339208(uc010wdg.2) ENST00000590102 ENST00000345615 ENST00000502449
    ENST00000394378 ENST00000585472 ENST00000591288 ENST00000508220 ENST00000591427
    ENST00000421408(uc002hof.3 uc010cvd.1) ENST00000588194 ENST00000587040
    ENST00000378189(uc002hog.1) ENST00000394379(uc010wdh.1) ENST00000427923
    ENST00000585689 ENST00000346661(uc010wde.2 uc002hoa.3 uc010wdf.2 uc002hoc.3 uc002hoe.3 uc002hod.3 uc002hob.3)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SYNRG using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SYNRG (see all 80):
    hsa-miR-579 hsa-miR-520e hsa-miR-520f hsa-miR-607 hsa-miR-106a hsa-miR-15a hsa-miR-128 hsa-miR-877*
    SwitchGear 3'UTR luciferase reporter plasmidSYNRG 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SYNRG
    Predesigned siRNA for gene silencing in human, mouse, rat SYNRG
    Clone
    Products:
         
    OriGene clones in human, mouse for SYNRG (see all 38)
    OriGene ORF clones in mouse, rat for SYNRG
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 7): SYNRG (NM_007247)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SYNRG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYNRG
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for SYNRG
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat SYNRG
      QuantiTect SYBR Green Assays in human, mouse, rat SYNRG
      QuantiFast Probe-based Assays in human, mouse, rat SYNRG

    Additional mRNA sequence: 

    AF169548.1 AK025335.1 AK025700.1 AK091801.1 AK126988.1 AK302821.1 AK308292.1 BC084536.1 
    BC090930.1 BC117313.1 BC143452.1 BC143476.1 BC143478.1 

    19 DOTS entries:

    DT.92426606  DT.413577  DT.100755113  DT.101970755  DT.121002228  DT.92426615  DT.100712266  DT.40274797 
    DT.100755110  DT.92012963  DT.100755114  DT.100778583  DT.75106161  DT.91939598  DT.95259769  DT.99995749 
    DT.101970630  DT.213162  DT.91988915 

    Selected AceView cDNA sequences (see all 266):

    BE502803 BU737980 AI224924 BQ072680 CB162700 AI480384 AW500979 AW152226 
    AI242391 AI457149 AA928162 N79990 AK126988 AI934981 AI922449 AW204047 
    AW963700 AW611549 AA650561 BQ221603 AA036899 AI688315 BM452440 BE247534 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SYNRG (see all 7)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c · 17d · 17e ^
    SP1:        -                                   -     -     -                                   -           -                                               -   
    SP2:                                                        -                                                                                                   
    SP3:                                                                                            -           -                       -                           
    SP4:                                                                                                                                                        -   
    SP5:                                                                                            -                                                               

    ExUns: 18a · 18b ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23 ^ 24
    SP1:                                            -         
    SP2:                                                      
    SP3:                                                      
    SP4:  -                                                   
    SP5:                                                      


    ECgene alternative splicing isoforms for SYNRG

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    SYNRG expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGGACATCT
    SYNRG Expression
    About this image

    SYNRG Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SYNRG Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.594647
        Custom PCR Arrays for SYNRG
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for SYNRG
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat SYNRG
    QuantiTect SYBR Green Assays in human, mouse, rat SYNRG
    QuantiFast Probe-based Assays in human, mouse, rat SYNRG
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYNRG

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for SYNRG gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Synrg1 , 5 synergin, gamma1, 5 81.57(n)1
    82.89(a)1
      11 (51.25 cM)5
    2170301  NM_194341.21  NP_919322.11 
     839644285 
    chicken
    (Gallus gallus)
    Aves SYNRG1 synergin, gamma 74.98(n)
    75.29(a)
      417658  XM_004946749.1  XP_004946806.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    Uncharacterized protein
    (see all 3)
    71(a)
    57(a)
    (see all 3)
    many → 1
    many → 1
    (see all 3)
    GL343439.1(90-25398)
    GL344757.1(552-15890)
    African clawed frog
    (Xenopus laevis)
    Amphibia BU912051.12   -- 76.42(n)    BU912051.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BG306519.12   -- 77.14(n)    BG306519.1 
    worm
    (Caenorhabditis elegans)
    Secernentea R10E11.66
    Protein R10E11.6, isoform a
    31(a)
    1 ↔ 1
    III(9783325-9786038) WBGene00011218


    ENSEMBL Gene Tree for SYNRG (if available)
    TreeFam Gene Tree for SYNRG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for SYNRG (see all 1899)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs603816931,2
    C--35874594(+) AAAAA-/A/A   
       A
    /AAA
    TCCAG
    14 -- ds5001 cds11NA 2
    rs558095751,2
    C,F--35874686(+) TAGGGC/TGAGAA 7 -- ds50011Minor allele frequency- T:0.50WA 2
    rs728282931,2
    C,F--35874829(+) TGGGCC/TCCTGT 7 -- ds50011Minor allele frequency- T:0.03NA 120
    rs1404952761,2
    --35874915(+) TTCTTC/TTACAC 7 -- ut310--------
    rs10632151,2
    C,F,A,H--35874936(-) ACTTCC/TCTAAC 7 -- ut3126Minor allele frequency- T:0.18MN NA NS EA WA CSA 2673
    rs66072761,2
    C,H--35874989(+) AAGGTA/GAAGCT 7 -- ut3115Minor allele frequency- G:0.00NS EA NA WA CSA 790
    rs1861069631,2
    --35875090(+) ATTCCA/GCATCA 7 -- ut310--------
    rs1910555621,2
    --35875327(+) TCCTCA/GGCCTG 7 -- ut310--------
    rs1823456631,2
    --35875454(+) TGCTGA/GAATGG 7 -- ut310--------
    rs176969791,2
    C,F,H--35875487(+) CCTTCT/GGAATG 7 -- ut3116Minor allele frequency- G:0.07NA NS EA CSA WA 2030

    HapMap Linkage Disequilibrium report for SYNRG (35874900 - 35969544 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for SYNRG:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2657174CNV Deletion23128226
    esv271409CNV Insertion20981092
    esv274399CNV Insertion20981092
    nsv827979CNV Loss20364138
    nsv833431CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SYNRG
    DNA2.0 Custom Variant and Variant Library Synthesis for SYNRG

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 607291    OMIM disorders: --

    3 diseases for SYNRG:    About MalaCards
    gastroenteritis    ovarian cancer    endotheliitis


    SYNRG for disorders           About GeneDecksing


    Export disorders for SYNRG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for SYNRG gene, integrated from 10 sources (see all 37):
    (articles sorted by number of sources associating them with SYNRG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Gamma-synergin: an EH domain-containing protein that interacts with gamma-adaptin. (PubMed id 10477754)1, 2, 3 Page L.J.... Robinson M.S. (J. Cell Biol. 1999)
    2. EpsinR: an AP1/clathrin interacting protein involved in vesicle trafficking. (PubMed id 12538641)1, 2, 9 Mills I.G.... McMahon H.T. (J. Cell Biol. 2003)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Adaptor gamma ear homology domain conserved in gamma-adaptin and GGA proteins that interact with gamma-synergin. (PubMed id 10814529)1, 2 Takatsu H.... Nakayama K. (Biochem. Biophys. Res. Commun. 2000)
    6. Aftiphilin and gamma-synergin are required for secretagogue sensitivity of Weibel-Palade bodies in endothelial cells. (PubMed id 18815278)1, 9 Lui-Roberts W.W....Cutler D.F. (Mol. Biol. Cell 2008)
    7. Gamma-adaptin appendage domain: structure and binding site for Eps15 and gamma-synergin. (PubMed id 12176391)1, 9 Kent H.M....Owen D.J. (Structure 2002)
    8. The aftiphilin/p200/gamma-synergin complex. (PubMed id 15758025)1, 9 Hirst J....Robinson M.S. (Mol. Biol. Cell 2005)
    9. SCAMP1 function in endocytosis. (PubMed id 10777571)1, 9 FernA!ndez-ChacA^n R....SA1dhof T.C. (J. Biol. Chem. 2000)
    10. GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer. (PubMed id 23535730)1 Pharoah P.D....Sellers T.A. (Nat. Genet. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 11276 HGNC: 557 AceView: AP1GBP1 Ensembl:ENSG00000006114 euGenes: HUgn11276
    ECgene: SYNRG H-InvDB: SYNRG

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SYNRG Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SYNRG gene:
    Search GeneIP for patents involving SYNRG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SYNRG  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for SYNRG  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SYNRG  
     OriGene qSTAR qPCR primer pairs in human, mouse for SYNRG   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for SYNRG   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SYNRG   OriGene Custom Protein Services for SYNRG  

     
     
     Block miRNA regulation of human, mouse, rat SYNRG using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SYNRG
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SYNRG Predesigned siRNA for gene silencing in human, mouse, rat SYNRG
     QuantiFast Probe-based Assays in human, mouse, rat SYNRG QuantiTect SYBR Green Assays in human, mouse, rat SYNRG
     Custom PCR Arrays for SYNRG Search Chromatin IP Primers for SYNRG
     Pre-validated RT2 qPCR Primer Assay in human, mouse / rat SYNRG  GeneGlobe Interaction Network for SYNRG
     Search Regulatory tfbs for SYNRG
     GenScript Custom Purified and Recombinant Proteins Services for SYNRG GenScript cDNA clones with any tag delivered in your preferred vector for SYNRG
     GenScript Custom Assay Services for SYNRG GenScript Custom overexpressing Cell Line Services for SYNRG
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for SYNRG
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SYNRG antibodies
     SYNRG proteins
     SYNRG lysates
     Antibodies for SYNRG
     See all of Abcam's Antibodies, Kits and Proteins for SYNRG
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for SYNRG
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYNRG
     SwitchGear 3'UTR luciferase reporter plasmids for SYNRG
     SwitchGear Promoter luciferase reporter plasmids for SYNRG
     Search ThermoFisher Antibodies for SYNRG
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYNRG
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SYNRG
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SYNRG
     LSBio Antibodies in human, mouse, rat for SYNRG
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SYNRG gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4