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Aliases for SYNRG Gene

Aliases for SYNRG Gene

  • Synergin, Gamma 2 3
  • Gamma-Synergin 2 3 4
  • AP1GBP1 3 4 6
  • SYNG 3 4 6
  • Adaptor-Related Protein Complex 1 Gamma Subunit-Binding Protein 1 2 3
  • AP1 Gamma Subunit Binding Protein 1 2 3
  • AP1 Subunit Gamma-Binding Protein 1 3 4
  • Synergin Gamma 3

External Ids for SYNRG Gene

Previous HGNC Symbols for SYNRG Gene

  • AP1GBP1

Previous GeneCards Identifiers for SYNRG Gene

  • GC17M032953
  • GC17M035874
  • GC17M031812

Summaries for SYNRG Gene

Entrez Gene Summary for SYNRG Gene

  • This gene encodes a protein that interacts with the gamma subunit of AP1 clathrin-adaptor complex. The AP1 complex is located at the trans-Golgi network and associates specific proteins with clathrin-coated vesicles. This encoded protein may act to connect the AP1 complex to other proteins. Alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for SYNRG Gene

SYNRG (Synergin, Gamma) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding.

UniProtKB/Swiss-Prot for SYNRG Gene

  • May play a role in endocytosis and/or membrane trafficking at the trans-Golgi network (TGN). May act by linking the adapter protein complex AP-1 to other proteins

Gene Wiki entry for SYNRG Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYNRG Gene

Genomics for SYNRG Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SYNRG Gene

Start:
37,514,797 bp from pter
End:
37,609,496 bp from pter
Size:
94,700 bases
Orientation:
Minus strand

Genomic View for SYNRG Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SYNRG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYNRG Gene

No data available for Regulatory Elements for SYNRG Gene

Proteins for SYNRG Gene

  • Protein details for SYNRG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UMZ2-SYNRG_HUMAN
    Recommended name:
    Synergin gamma
    Protein Accession:
    Q9UMZ2
    Secondary Accessions:
    • A8MWU4
    • B7ZKZ2
    • B7ZKZ3
    • Q17RI2
    • Q5BKU5
    • Q6ZT17

    Protein attributes for SYNRG Gene

    Size:
    1314 amino acids
    Molecular mass:
    140654 Da
    Quaternary structure:
    • Interacts with SCAMP1 via its EH-domain (By similarity). Interacts with GGA1, GGA2 and GGA3. Interacts with the AP1G1 and AP1G2 subunits of the adapter protein complexes AP-1.
    SequenceCaution:
    • Sequence=AK126988; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Alternative splice isoforms for SYNRG Gene

neXtProt entry for SYNRG Gene

Proteomics data for SYNRG Gene at MOPED

Post-translational modifications for SYNRG Gene

  • Ubiquitination at Lys907 and Lys928
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SYNRG Gene

Domains for SYNRG Gene

Protein Domains for SYNRG Gene

Suggested Antigen Peptide Sequences for SYNRG Gene

Graphical View of Domain Structure for InterPro Entry

Q9UMZ2

UniProtKB/Swiss-Prot:

SYNRG_HUMAN :
  • Q9UMZ2
Domain:
  • The DFXDF motifs mediate the interaction with gamma-appendage subunits AP1G1 and AP1G2.
  • Contains 1 EH domain.
genes like me logo Genes that share domains with SYNRG: view

No data available for Gene Families for SYNRG Gene

Function for SYNRG Gene

Molecular function for SYNRG Gene

UniProtKB/Swiss-Prot Function: May play a role in endocytosis and/or membrane trafficking at the trans-Golgi network (TGN). May act by linking the adapter protein complex AP-1 to other proteins

Gene Ontology (GO) - Molecular Function for SYNRG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SYNRG: view

Animal Model Products

CRISPR Products

miRNA for SYNRG Gene

miRTarBase miRNAs that target SYNRG

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SYNRG

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SYNRG Gene

Localization for SYNRG Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYNRG Gene

Cytoplasm. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Note=Associates with membranes via the adapter protein complex AP-1. Colocalizes with AP1G1 (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SYNRG Gene COMPARTMENTS Subcellular localization image for SYNRG gene
Compartment Confidence
golgi apparatus 4
cytosol 3
nucleus 3

Gene Ontology (GO) - Cellular Components for SYNRG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 10477754
GO:0005794 Golgi apparatus TAS 10477754
GO:0030121 AP-1 adaptor complex TAS 10477754
genes like me logo Genes that share ontologies with SYNRG: view

Pathways for SYNRG Gene

SuperPathways for SYNRG Gene

No Data Available

Interacting Proteins for SYNRG Gene

Gene Ontology (GO) - Biological Process for SYNRG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport TAS 10477754
GO:0006897 endocytosis IEA --
genes like me logo Genes that share ontologies with SYNRG: view

No data available for Pathways by source for SYNRG Gene

Compounds for SYNRG Gene

(1) Novoseek inferred chemical compound relationships for SYNRG Gene

Compound -log(P) Hits PubMed IDs
mannose 6-phosphate 69.6 1
genes like me logo Genes that share compounds with SYNRG: view

Transcripts for SYNRG Gene

Unigene Clusters for SYNRG Gene

Synergin, gamma:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SYNRG

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SYNRG

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SYNRG Gene

No ASD Table

Relevant External Links for SYNRG Gene

GeneLoc Exon Structure for
SYNRG
ECgene alternative splicing isoforms for
SYNRG

Expression for SYNRG Gene

mRNA expression in normal human tissues for SYNRG Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for SYNRG Gene

SOURCE GeneReport for Unigene cluster for SYNRG Gene Hs.594647

genes like me logo Genes that share expressions with SYNRG: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SYNRG Gene

Orthologs for SYNRG Gene

This gene was present in the common ancestor of chordates.

Orthologs for SYNRG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SYNRG 35
  • 99.67 (n)
  • 99.7 (a)
cow
(Bos Taurus)
Mammalia SYNRG 35
  • 87.61 (n)
  • 88.04 (a)
dog
(Canis familiaris)
Mammalia SYNRG 35
  • 90.16 (n)
  • 89.8 (a)
mouse
(Mus musculus)
Mammalia Synrg 35
  • 81.57 (n)
  • 82.89 (a)
Synrg 16
rat
(Rattus norvegicus)
Mammalia Synrg 35
  • 82.45 (n)
  • 82.4 (a)
chicken
(Gallus gallus)
Aves SYNRG 35
  • 74.98 (n)
  • 75.29 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia synrg 35
  • 61.08 (n)
  • 55.62 (a)
zebrafish
(Danio rerio)
Actinopterygii synrg 35
  • 63.04 (n)
  • 63.01 (a)
Species with no ortholog for SYNRG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SYNRG Gene

ENSEMBL:
Gene Tree for SYNRG (if available)
TreeFam:
Gene Tree for SYNRG (if available)

Paralogs for SYNRG Gene

No data available for Paralogs for SYNRG Gene

Variants for SYNRG Gene

Sequence variations from dbSNP and Humsavar for SYNRG Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1416 -- 37,534,709(+) AAGTT(C/T)TGGAA intron-variant
rs739740 -- 37,527,289(+) ACCTA(C/T)TGAAC intron-variant
rs746577 -- 37,527,324(+) CCTTA(A/G)ATGAC intron-variant
rs763512 -- 37,529,428(-) ATAGA(C/T)TACTC intron-variant
rs1034686 -- 37,539,039(+) CACCT(A/T)AGATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SYNRG Gene

Variant ID Type Subtype PubMed ID
nsv827979 CNV Loss 20364138
nsv833431 CNV Gain 17160897
esv274399 CNV Insertion 20981092
esv271409 CNV Insertion 20981092
esv2657174 CNV Deletion 23128226

Relevant External Links for SYNRG Gene

HapMap Linkage Disequilibrium report
SYNRG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SYNRG Gene

Disorders for SYNRG Gene

No disorders were found for SYNRG Gene.

No data available for UniProtKB/Swiss-Prot for SYNRG Gene

Publications for SYNRG Gene

  1. EpsinR: an AP1/clathrin interacting protein involved in vesicle trafficking. (PMID: 12538641) Mills I.G. … McMahon H.T. (J. Cell Biol. 2003) 3 4 23
  2. Gamma-synergin: an EH domain-containing protein that interacts with gamma-adaptin. (PMID: 10477754) Page L.J. … Robinson M.S. (J. Cell Biol. 1999) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Adaptor gamma ear homology domain conserved in gamma-adaptin and GGA proteins that interact with gamma-synergin. (PMID: 10814529) Takatsu H. … Nakayama K. (Biochem. Biophys. Res. Commun. 2000) 3 4
  5. SCAMP1 function in endocytosis. (PMID: 10777571) FernA!ndez-ChacA^n R. … SA1dhof T.C. (J. Biol. Chem. 2000) 3 23

Products for SYNRG Gene

Sources for SYNRG Gene

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