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Aliases for SYNPR Gene

Aliases for SYNPR Gene

  • Synaptoporin 2 3
  • SPO 3

External Ids for SYNPR Gene

Previous GeneCards Identifiers for SYNPR Gene

  • GC00U991103
  • GC03P062831
  • GC03P063118
  • GC03P063386
  • GC03P063404

Summaries for SYNPR Gene

GeneCards Summary for SYNPR Gene

SYNPR (Synaptoporin) is a Protein Coding gene. GO annotations related to this gene include transporter activity. An important paralog of this gene is SYPL1.

UniProtKB/Swiss-Prot for SYNPR Gene

  • Intrinsic membrane protein of small synaptic vesicles. Probable vesicular channel protein (By similarity).

Gene Wiki entry for SYNPR Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYNPR Gene

Genomics for SYNPR Gene

Regulatory Elements for SYNPR Gene

Genomic Location for SYNPR Gene

Chromosome:
3
Start:
63,200,409 bp from pter
End:
63,616,924 bp from pter
Size:
416,516 bases
Orientation:
Plus strand

Genomic View for SYNPR Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SYNPR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYNPR Gene

Proteins for SYNPR Gene

  • Protein details for SYNPR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TBG9-SYNPR_HUMAN
    Recommended name:
    Synaptoporin
    Protein Accession:
    Q8TBG9
    Secondary Accessions:
    • B2R675
    • G5E9W4

    Protein attributes for SYNPR Gene

    Size:
    265 amino acids
    Molecular mass:
    29166 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SYNPR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SYNPR Gene

Proteomics data for SYNPR Gene at MOPED

Post-translational modifications for SYNPR Gene

  • Glycosylation at Asn 33 and Asn 38
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SYNPR Gene

Domains & Families for SYNPR Gene

Protein Domains for SYNPR Gene

Suggested Antigen Peptide Sequences for SYNPR Gene

Graphical View of Domain Structure for InterPro Entry

Q8TBG9

UniProtKB/Swiss-Prot:

SYNPR_HUMAN :
  • Contains 1 MARVEL domain.
  • Belongs to the synaptophysin/synaptobrevin family.
Domain:
  • Contains 1 MARVEL domain.
Family:
  • Belongs to the synaptophysin/synaptobrevin family.
genes like me logo Genes that share domains with SYNPR: view

No data available for Gene Families for SYNPR Gene

Function for SYNPR Gene

Molecular function for SYNPR Gene

UniProtKB/Swiss-Prot Function:
Intrinsic membrane protein of small synaptic vesicles. Probable vesicular channel protein (By similarity).

Gene Ontology (GO) - Molecular Function for SYNPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SYNPR: view

Phenotypes for SYNPR Gene

MGI mutant phenotypes for SYNPR:
inferred from 1 alleles
GenomeRNAi human phenotypes for SYNPR:
genes like me logo Genes that share phenotypes with SYNPR: view

Animal Models for SYNPR Gene

MGI Knock Outs for SYNPR:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SYNPR

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for SYNPR Gene

Localization for SYNPR Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYNPR Gene

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein. Cell junction, synapse, synaptosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SYNPR Gene COMPARTMENTS Subcellular localization image for SYNPR gene
Compartment Confidence
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SYNPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008021 synaptic vesicle --
GO:0016020 membrane --
GO:0030054 cell junction IEA --
GO:0030285 integral component of synaptic vesicle membrane IBA --
GO:0030672 synaptic vesicle membrane IEA --
genes like me logo Genes that share ontologies with SYNPR: view

Pathways & Interactions for SYNPR Gene

SuperPathways for SYNPR Gene

No Data Available

Gene Ontology (GO) - Biological Process for SYNPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
genes like me logo Genes that share ontologies with SYNPR: view

No data available for Pathways by source and SIGNOR curated interactions for SYNPR Gene

Drugs & Compounds for SYNPR Gene

No Compound Related Data Available

Transcripts for SYNPR Gene

Unigene Clusters for SYNPR Gene

Synaptoporin:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SYNPR

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SYNPR Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7
SP1: - -
SP2: -
SP3: -
SP4: - - -

Relevant External Links for SYNPR Gene

GeneLoc Exon Structure for
SYNPR
ECgene alternative splicing isoforms for
SYNPR

Expression for SYNPR Gene

mRNA expression in normal human tissues for SYNPR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SYNPR Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x13.0), Brain - Caudate (basal ganglia) (x8.1), Brain - Putamen (basal ganglia) (x6.8), and Brain - Cerebellar Hemisphere (x4.6).

Protein differential expression in normal tissues from HIPED for SYNPR Gene

This gene is overexpressed in Retina (40.0), Brain (18.7), and Frontal cortex (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SYNPR Gene



SOURCE GeneReport for Unigene cluster for SYNPR Gene Hs.648668

genes like me logo Genes that share expression patterns with SYNPR: view

Protein tissue co-expression partners for SYNPR Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for SYNPR Gene

Orthologs for SYNPR Gene

This gene was present in the common ancestor of animals.

Orthologs for SYNPR Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SYNPR 35
  • 90.79 (n)
  • 93.77 (a)
SYNPR 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SYNPR 35
  • 92.16 (n)
  • 97.19 (a)
SYNPR 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Synpr 35
  • 89.47 (n)
  • 95.44 (a)
Synpr 16
Synpr 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SYNPR 35
  • 99.53 (n)
  • 99.65 (a)
SYNPR 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Synpr 35
  • 89.36 (n)
  • 98.05 (a)
oppossum
(Monodelphis domestica)
Mammalia SYNPR 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SYNPR 36
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves SYNPR 35
  • 77.39 (n)
  • 84.31 (a)
SYNPR 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SYNPR 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia synpr 35
  • 76.38 (n)
  • 83 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC558290 35
  • 66.31 (n)
  • 68.82 (a)
synpr 36
  • 49 (a)
OneToMany
SYNPR (1 of 2) 36
  • 62 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sph-1 36
  • 25 (a)
OneToMany
Species with no ortholog for SYNPR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SYNPR Gene

ENSEMBL:
Gene Tree for SYNPR (if available)
TreeFam:
Gene Tree for SYNPR (if available)

Paralogs for SYNPR Gene

Paralogs for SYNPR Gene

(4) SIMAP similar genes for SYNPR Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with SYNPR: view

Variants for SYNPR Gene

Sequence variations from dbSNP and Humsavar for SYNPR Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs727777 -- 63,420,296(+) GGCAA(C/T)GTTAT intron-variant
rs727778 -- 63,420,448(+) TGCAA(A/C/G)TCAGT intron-variant
rs727779 -- 63,420,336(+) TATAA(C/T)TAAAA intron-variant
rs870364 -- 63,300,578(+) AGTCC(C/G)TGCTC intron-variant
rs935786 -- 63,357,190(-) TACAG(C/T)GATGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SYNPR Gene

Variant ID Type Subtype PubMed ID
nsv876883 CNV Gain 21882294
esv25050 CNV Loss 19812545
esv1548229 CNV Insertion 17803354
esv2422509 CNV Deletion 17116639
esv23041 CNV Loss 19812545
nsv876884 CNV Gain 21882294
nsv3848 CNV Insertion 18451855
esv273179 CNV Insertion 20981092
esv271251 CNV Insertion 20981092
nsv834716 CNV Loss 17160897
nsv876885 CNV Loss 21882294
esv1696258 CNV Deletion 17803354

Variation tolerance for SYNPR Gene

Residual Variation Intolerance Score: 37.59% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.89; 18.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SYNPR Gene

HapMap Linkage Disequilibrium report
SYNPR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SYNPR Gene

Disorders for SYNPR Gene

Relevant External Links for SYNPR

Genetic Association Database (GAD)
SYNPR
Human Genome Epidemiology (HuGE) Navigator
SYNPR
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SYNPR
genes like me logo Genes that share disorders with SYNPR: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SYNPR Gene

Publications for SYNPR Gene

  1. Cloning and sequence analysis of the human cDNA encoding the synaptoporin (delta), a highly conservative synaptic vesicle protein. (PMID: 12974474) Dai J. … Mao Y. (Mol. Biol. Rep. 2003) 2 23 67
  2. Expression of the synaptophysin gene family is not restricted to neuronal and neuroendocrine differentiation in rat and human. (PMID: 8034131) Leube R.E. (Differentiation 1994) 2 23 67
  3. Tetraspan vesicle membrane proteins: synthesis, subcellular localization, and functional properties. (PMID: 11893164) HA1bner K. … Leube R.E. (Int. Rev. Cytol. 2002) 23 67
  4. Neurosecretory vesicles can be hybrids of synaptic vesicles and secretory granules. (PMID: 7638193) Bauerfeind R. … Huttner W.B. (Proc. Natl. Acad. Sci. U.S.A. 1995) 23 67
  5. Synaptobrevin binding to synaptophysin: a potential mechanism for controlling the exocytotic fusion machine. (PMID: 7835333) Edelmann L. … Jahn R. (EMBO J. 1995) 23 67

Products for SYNPR Gene

Sources for SYNPR Gene

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