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Aliases for SYNPO2L Gene

Aliases for SYNPO2L Gene

  • Synaptopodin 2 Like 2 3 5
  • Synaptopodin 2-Like 2

External Ids for SYNPO2L Gene

Previous GeneCards Identifiers for SYNPO2L Gene

  • GC10M074749
  • GC10M075076
  • GC10M075404
  • GC10M069398

Summaries for SYNPO2L Gene

GeneCards Summary for SYNPO2L Gene

SYNPO2L (Synaptopodin 2 Like) is a Protein Coding gene. GO annotations related to this gene include actin binding. An important paralog of this gene is SYNPO2.

UniProtKB/Swiss-Prot for SYNPO2L Gene

  • Actin-associated protein that may play a role in modulating actin-based shape.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYNPO2L Gene

Genomics for SYNPO2L Gene

Regulatory Elements for SYNPO2L Gene

Enhancers for SYNPO2L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10G073588 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.5 +72.5 72492 5.9 PKNOX1 FOXA2 MLX ZFP64 ARID4B FEZF1 DMAP1 SLC30A9 ZNF766 FOS NUDT13 USP54 RNU6-883P SYNPO2L AP3M1 CAMK2G PPP3CB CFAP70 GC10P073587 GC10P073609
GH10G073575 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.1 +86.5 86495 3.0 INSM2 ZNF2 RAD21 YY1 FOS RELB IKZF2 ZNF263 ZNF362 CEBPB USP54 SYNPO2L RNU6-883P NUDT13 PPP3CB CAMK2G CFAP70 C10orf55 GC10P073575 GC10P073587
GH10G073646 1.9 FANTOM5 Ensembl ENCODE dbSUPER 9.1 +11.7 11739 11.0 HDGF FOXA2 PKNOX1 ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 MYOZ1 ECD ENSG00000272791 AP3M1 ENSG00000272140 FUT11 BMS1P4 DUSP8P5 GLUD1P3 ENSG00000268584
GH10G073584 1.6 Ensembl ENCODE dbSUPER 10.4 +77.5 77463 2.9 PKNOX1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF766 CBX5 NUDT13 CFAP70 USP54 RNU6-883P ENSG00000272630 PPP3CB PPP3CB-AS1 SYNPO2L GC10P073587 GC10P073575
GH10G073780 1.4 ENCODE dbSUPER 10.7 -118.2 -118157 2.6 PKNOX1 CREB3L1 AGO1 WRNIP1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF766 ZSWIM8 ECD AP3M1 GLUD1P3 DUSP8P5 MYOZ1 ENSG00000272140 NDST2 BMS1P4 ENSG00000224195
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SYNPO2L on UCSC Golden Path with GeneCards custom track

Genomic Location for SYNPO2L Gene

73,644,881 bp from pter
73,663,803 bp from pter
18,923 bases
Minus strand

Genomic View for SYNPO2L Gene

Genes around SYNPO2L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SYNPO2L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SYNPO2L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYNPO2L Gene

Proteins for SYNPO2L Gene

  • Protein details for SYNPO2L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Synaptopodin 2-like protein
    Protein Accession:
    Secondary Accessions:
    • A5PKV9
    • Q68A20

    Protein attributes for SYNPO2L Gene

    977 amino acids
    Molecular mass:
    102481 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SYNPO2L Gene


neXtProt entry for SYNPO2L Gene

Post-translational modifications for SYNPO2L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SYNPO2L Gene

No data available for DME Specific Peptides for SYNPO2L Gene

Domains & Families for SYNPO2L Gene

Gene Families for SYNPO2L Gene

Protein Domains for SYNPO2L Gene


Suggested Antigen Peptide Sequences for SYNPO2L Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the synaptopodin family.
  • Belongs to the synaptopodin family.
genes like me logo Genes that share domains with SYNPO2L: view

Function for SYNPO2L Gene

Molecular function for SYNPO2L Gene

UniProtKB/Swiss-Prot Function:
Actin-associated protein that may play a role in modulating actin-based shape.

Gene Ontology (GO) - Molecular Function for SYNPO2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IBA --
genes like me logo Genes that share ontologies with SYNPO2L: view

Phenotypes for SYNPO2L Gene

genes like me logo Genes that share phenotypes with SYNPO2L: view

Animal Model Products

CRISPR Products

miRNA for SYNPO2L Gene

miRTarBase miRNAs that target SYNPO2L

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SYNPO2L Gene

Localization for SYNPO2L Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYNPO2L Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SYNPO2L gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 3

Gene Ontology (GO) - Cellular Components for SYNPO2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
GO:0005856 cytoskeleton IEA --
GO:0015629 actin cytoskeleton IBA --
genes like me logo Genes that share ontologies with SYNPO2L: view

Pathways & Interactions for SYNPO2L Gene

SuperPathways for SYNPO2L Gene

No Data Available

Interacting Proteins for SYNPO2L Gene

Gene Ontology (GO) - Biological Process for SYNPO2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032233 positive regulation of actin filament bundle assembly IBA --
genes like me logo Genes that share ontologies with SYNPO2L: view

No data available for Pathways by source and SIGNOR curated interactions for SYNPO2L Gene

Drugs & Compounds for SYNPO2L Gene

No Compound Related Data Available

Transcripts for SYNPO2L Gene

Unigene Clusters for SYNPO2L Gene

Synaptopodin 2-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SYNPO2L Gene

No ASD Table

Relevant External Links for SYNPO2L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SYNPO2L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SYNPO2L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SYNPO2L Gene

This gene is overexpressed in Heart - Left Ventricle (x20.8), Muscle - Skeletal (x15.7), and Heart - Atrial Appendage (x13.5).

Protein differential expression in normal tissues from HIPED for SYNPO2L Gene

This gene is overexpressed in Heart (43.3) and Fetal heart (24.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SYNPO2L Gene

Protein tissue co-expression partners for SYNPO2L Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SYNPO2L Gene:


SOURCE GeneReport for Unigene cluster for SYNPO2L Gene:


Evidence on tissue expression from TISSUES for SYNPO2L Gene

  • Heart(4.7)
  • Muscle(3.5)
genes like me logo Genes that share expression patterns with SYNPO2L: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SYNPO2L Gene

Orthologs for SYNPO2L Gene

This gene was present in the common ancestor of chordates.

Orthologs for SYNPO2L Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SYNPO2L 34 35
  • 99.66 (n)
(Canis familiaris)
Mammalia SYNPO2L 34 35
  • 88.42 (n)
(Bos Taurus)
Mammalia SYNPO2L 34 35
  • 87.85 (n)
(Rattus norvegicus)
Mammalia Synpo2l 34
  • 84.67 (n)
(Mus musculus)
Mammalia Synpo2l 34 16 35
  • 84.33 (n)
(Monodelphis domestica)
Mammalia SYNPO2L 35
  • 78 (a)
(Gallus gallus)
Aves SYNPO2L 34 35
  • 62.07 (n)
(Anolis carolinensis)
Reptilia SYNPO2L 35
  • 51 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia synpo2l 34
  • 56.54 (n)
(Danio rerio)
Actinopterygii synpo2lb 34 35
  • 60.22 (n)
SYNPO2L (1 of 2) 35
  • 40 (a)
Species where no ortholog for SYNPO2L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SYNPO2L Gene

Gene Tree for SYNPO2L (if available)
Gene Tree for SYNPO2L (if available)

Paralogs for SYNPO2L Gene

Paralogs for SYNPO2L Gene

(1) SIMAP similar genes for SYNPO2L Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SYNPO2L: view

Variants for SYNPO2L Gene

Sequence variations from dbSNP and Humsavar for SYNPO2L Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000261009 -- 73,648,745(+) TCTCT(A/G)CCGCC reference, stop-gained
rs1000630062 -- 73,646,854(+) GAGGG(G/T)CTGGG reference, missense
rs1000878347 -- 73,656,242(+) CTTTT(A/T)TTCAG intron-variant, upstream-variant-2KB
rs1001060689 -- 73,653,757(+) GGTAA(A/G)GGAGA intron-variant, upstream-variant-2KB
rs1001377793 -- 73,652,434(+) GAGGC(C/T)GAGGT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SYNPO2L Gene

Variant ID Type Subtype PubMed ID
nsv831912 CNV gain 17160897

Variation tolerance for SYNPO2L Gene

Residual Variation Intolerance Score: 15.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.28; 96.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SYNPO2L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SYNPO2L Gene

Disorders for SYNPO2L Gene

Relevant External Links for SYNPO2L

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SYNPO2L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SYNPO2L Gene

Publications for SYNPO2L Gene

  1. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 46 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4 64
  4. Meta-analysis identifies six new susceptibility loci for atrial fibrillation. (PMID: 22544366) Ellinor P.T. … KAoAob S. (Nat. Genet. 2012) 3 64
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64

Products for SYNPO2L Gene

Sources for SYNPO2L Gene

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