SYNPO2 Gene
protein-coding GIFtS : 51
GCID: GC04 P119809
synaptopodin 2
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Aliasesfor SYNPO2 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Synaptopodin 2 1 2 Myopodin3 MYOPODIN1 Synaptopodin-21 Genethonin 22 Genethonin-23 Genethonin-23 Myopodin3
Export aliases for SYNPO2 gene to outside databases Previous GC identifers: GC04P120706 GC04P120090 GC04P120203 GC04P120269 GC04P120270 GC04P120167 GC04P115532
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Summariesfor SYNPO2 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: SYNP2_HUMAN, Q9UMS6 Function : Has an actin-binding and actin-bundling activity (By similarity)Gene Wiki entry for SYNPO2
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Genomic Viewsfor SYNPO2 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000004.11 NC_018915.1 NT_016354.19 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the SYNPO2 gene promoter: TBP Pax-5 ATF-2 MIF-1 C/EBPalpha CRE-BP1 CHOP-10 TFIID POU2F1a Other transcription factors Search SABiosciences Chromatin IP Primers for SYNPO2 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SYNPO2
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 4q26 Ensembl cytogenetic band: 4q26 HGNC cytogenetic band: 4q26 SYNPO2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 4 GeneLoc Exon Structure
GeneLoc location for GC04P119809: view genomic region
(about GC identifiers )
Start:
119,809,996 bp from pter
End:
119,982,402 bp from pter
Size:
172,407 bases
Orientation:
plus strand
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Proteinsfor SYNPO2 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: SYNP2_HUMAN, Q9UMS6 (See
protein sequence )Recommended Name: Synaptopodin-2 Size : 1093 amino acids; 117514 Da
Subunit : Interacts with actin (By similarity)
Subcellular location : Nucleus (By similarity). Cytoplasm (By similarity). Note=Shuttles between the nucleus and thecytoplasm in a differentiation-dependent and stress-induced fashion. Localizes to the Z-disk in mature striated muscle. The nuclear export is XPO1-dependent (By similarity). Localized in a fiber-like pattern. partly overlapping with filamentous actin
Secondary accessions : B2RWP6 B2Y8J9 Q9UK89Alternative splicing : 3 isoforms : Q9UMS6-1 Q9UMS6-2 Q9UMS6-3 Explore the universe of human proteins at neXtProt for SYNPO2: NX_Q9UMS6 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q9UMS6 SYNPO2 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins (3 alternative transcripts):
NP_001122405.1 NP_001122406.1 NP_597734.2 ENSEMBL proteins: ENSP00000306015 ENSP00000395143 ENSP00000390965 ENSP00000425496 ENSP00000412623 Human Recombinant Protein Products: Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view) : About this table
SYNPO2 for ontologies About GeneDecksing SYNPO2 Antibody Products: Assay Products for SYNPO2:
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Protein
Domains / Familiesfor SYNPO2 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
SYNPO2 for domains About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry Q9UMS6 ProtoNet protein and cluster: Q9UMS6
1 Blocks protein family : IPB001478 PDZ/DHR/GLGF domain UniProtKB/Swiss-Prot: SYNP2_HUMAN, Q9UMS6 Similarity : Belongs to the synaptopodin familySimilarity : Contains 1 PDZ (DHR) domain
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Functionfor SYNPO2 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: SYNP2_HUMAN, Q9UMS6 Function : Has an actin-binding and actin-bundling activity (By similarity)Induction : Down-regulated in muscle cell lines derived from patients with Duchenne muscular dystrophy (DMD)
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for SYNPO2 (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for SYNPO2 (see all 3 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): SYNPO2 (NM_024875 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SYNPO2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SYNPO2
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYNPO2
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view) : About this table
SYNPO2 for ontologies About GeneDecksing
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Pathways & Interactionsfor SYNPO2 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SYNPO2 STRING Interaction
Network Preview (showing 5 interactants - click image to see 6)5/8 Interacting proteins for SYNPO2 (Q9UMS6 1 , 2 , 3 ENSP00000306015 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 8 )About this table
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Drugs & Compoundsfor SYNPO2 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for SYNPO2 Search CenterWatch for drugs/clinical trials and news about SYNPO2 / SYNP2
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Transcriptsfor SYNPO2 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for SYNPO2 gene (3 alternative transcripts): NM_001128933.1 NM_001128934.1 NM_133477.2 Unigene Cluster for SYNPO2:
Synaptopodin 2 Hs.655519 [show with all ESTs ] Unigene Representative Sequence: NM_001128933 5 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000307142 (uc010inb.3 uc011cgh.2 uc010inc.3 ) ENST00000429713 (uc003icm.4 )ENST00000434046 (uc010ina.3 ) ENST00000504178 ENST00000448416 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for SYNPO2 (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for SYNPO2 (see all 3 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): SYNPO2 (NM_024875 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SYNPO2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SYNPO2
Additional cDNA sequence: AF177291.1 AJ010482.1 AK000774.1 AK021484.1 AK296962.1 AK304121.1 AK307711.1 AL832031.1 AL832363.1 AL833294.1 AL833547.1 BC136256.1 BC150629.1 BX647849.1 BX648090.1 CR936673.1 EU481975.1 FN422000.1
10 DOTS entries : DT.115185 DT.111063
DT.100659438 DT.413193 DT.91734350 DT.95151623 DT.75176385 DT.100687565 DT.121239608 DT.97822370 24/361 AceView cDNA sequences (see all 361 ):
Z38688 BF057516 AA112998 AI969816 F28522 AA631771 BF109968 AI696716 AW292003 AA468894 BE222491 BE646185 AI128071 AI266109 AL702162 AA043596 AI659702 AI418778 AI743706 BE048902 AI161120 AA114960 CR606797 AI674348 GeneLoc Exon Structure
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Expression for SYNPO2 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section SYNPO2 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TGTTTGAAAT
About this image SYNPO2 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See SYNPO2 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for SYNPO2 SOURCE GeneReport for Unigene cluster: Hs.655519 UniProtKB/Swiss-Prot: SYNP2_HUMAN, Q9UMS6 Tissue specificity : Skeletal muscle specific SABiosciences Custom PCR Arrays for SYNPO2 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for SYNPO2Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat SYNPO2 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat SYNPO2 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat SYNPO2 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYNPO2
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Orthologsfor SYNPO2 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for SYNPO2 gene from 3/10 species (see all 10 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
chicken (Gallus gallus)
Aves
SYNPO21
synaptopodin 2
66.31(n) 60.39(a)
 
428768 XM_426324.2 XP_426324.2
lizard (Anolis carolinensis)
Reptilia
SYNPO26
--
56(a)
1 ↔ 1
5(140177147-140213049)
zebrafish (Danio rerio)
Actinopterygii
LOC5705261
uncharacterized LOC570526
51.3(n) 44.2(a)
 
570526 XM_694019.5 XP_699111.5
ENSEMBL Gene Tree for SYNPO2 (if available)TreeFam Gene Tree for SYNPO2 (if available)
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Paralogsfor SYNPO2 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for SYNPO2 gene SYNPO 2 SYNPO2L 2 6 SIMAP similar genes for SYNPO2 using alignment to 5 protein entries: SYNP2_HUMAN (see all proteins ):PDLIM5 LDB3 PDLIM7 PDLIM2 SYNPO2L MAGI2
SYNPO2 for paralogs About GeneDecksing
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Genomic Variantsfor SYNPO2 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 2 variations for SYNPO2 1 CNV : 6312 1 Indel : 59166 SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing SYNPO2
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Disorders
/ Diseasesfor SYNPO2 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
SYNPO2 for disorders About GeneDecksing 9 diseases for SYNPO2 : About MalaCards duchenne muscular dystrophy myofibrillar myopathy muscular dystrophy urinary bladder cancer alcohol dependence myopathy prostate cancer alcoholism prostatitis 4 Novoseek disease relationships for SYNPO2 gene About this table
Human Genome Epidemiology (HuGE) Navigator: SYNPO2 (1 document)Export disorders for SYNPO2 gene to outside databases
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Publicationsfor SYNPO2 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for SYNPO2 gene, integrated from 9 sources (see all 33 ): (articles sorted by number of sources associating them with SYNPO2) Utopia : connect your pdf to the dynamic world of online information
Differentiation and stress-dependent nuclear-cytoplasmic redistribution of myopodin, a novel actin bundling protein. (PubMed id 11673475) 1 , 2 , 3 Weins A.... Mundel P. (2001) Interaction between importin 13 and myopodin suggests a nuclear import pathway for myopodin. (PubMed id 17828378) 1 , 3, 9 Liang J....Tao T. (2008) Multiple isoforms of the tumor suppressor myopodin are simultaneously transcribed in cancer cells. (PubMed id 18371299) 1 , 2 , 9 De Ganck A....Gettemans J. (2008) Expression of myopodin induces suppression of tumor growth and metastasis. (PubMed id 15111326) 1 , 9 Jing L....Luo J.H. (2004) Tumor suppressor role for myopodin in bladder cancer: loss of nuclear expression of myopodin is cell-cycle dependent and predicts clinical outcome. (PubMed id 12917631) 1 , 9 Sanchez-Carbayo M....Mundel P. (2003) Down-regulation of myopodin expression reduces invasion and motility of PC-3 prostate cancer cells. (PubMed id 19360353) 1 , 9 De Ganck A....Gettemans J. (2009) The Nucleo-cytoplasmic actin-binding protein CapG lacks a nuclear export sequence present in structurally related proteins. (PubMed id 12637565) 1 , 9 Van Impe K....Gettemans J. (2003) Diagnostic and prognostic utility of methylation and p rotein expression patterns of myopodin in colon cancer. (PubMed id 22252522) 1 Esteban S....Sanchez-Carbayo M. (2012) Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048) 1 Danielsen J.M....Nielsen M.L. (2011) Phosphorylation and interaction of myopodin by integr in-link kinase lead to suppression of cell growth and motility in prostate canc er cells. (PubMed id 21643011) 1 Yu Y.P. and Luo J.H. (2011)
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External Searches for SYNPO2 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing SYNPO2 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing SYNPO2 gene
(According to HUGE )
About This Section --
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Specialized Databases showing SYNPO2 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for SYNPO2 gene: Search GeneIP for patents involving SYNPO2 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor SYNPO2 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for SYNPO2 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for SYNPO2 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for SYNPO2 Browse OriGene Protein Over-expression Lysates Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for SYNPO2 OriGene 3'-UTR Clone for SYNPO2 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for SYNPO2 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for SYNPO2 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for SYNPO2 OriGene Custom Protein Services for SYNPO2 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SYNPO2 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing SYNPO2 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SYNPO2 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat SYNPO2 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat SYNPO2 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat SYNPO2
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SYNPO2 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYNPO2
ThermoFisher Antibodies for SYNPO2
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SYNPO2
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