Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SYNPO2 Gene

protein-coding   GIFtS: 53
GCID: GC04P119809

Synaptopodin 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Synaptopodin 21 2
genethonin-22
myopodin2
synaptopodin-22
Genethonin-23
Myopodin3

External Ids:    HGNC: 177321   Entrez Gene: 1710242   Ensembl: ENSG000001724037   UniProtKB: Q9UMS63   

Export aliases for SYNPO2 gene to outside databases

Previous GC identifers: GC04P120706 GC04P120090 GC04P120203 GC04P120269 GC04P120270 GC04P120167 GC04P115532


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for SYNPO2 Gene:
SYNPO2 (synaptopodin 2) is a protein-coding gene. Diseases associated with SYNPO2 include myofibrillar myopathy, and duchenne muscular dystrophy. GO annotations related to this gene include muscle alpha-actinin binding and actin binding. An important paralog of this gene is SYNPO.

UniProtKB/Swiss-Prot: SYNP2_HUMAN, Q9UMS6
Function: Has an actin-binding and actin-bundling activity (By similarity)

Gene Wiki entry for SYNPO2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000004.12  NC_018915.2  NT_016354.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the SYNPO2 gene promoter:
         TBP   Pax-5   ATF-2   MIF-1   C/EBPalpha   CRE-BP1   CHOP-10   TFIID   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SYNPO2 promoter sequence
   Search Chromatin IP Primers for SYNPO2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SYNPO2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q26   Ensembl cytogenetic band:  4q26   HGNC cytogenetic band: 4q26

SYNPO2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SYNPO2 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P119809:  view genomic region     (about GC identifiers)

Start:
119,809,996 bp from pter      End:
119,982,402 bp from pter
Size:
172,407 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: SYNP2_HUMAN, Q9UMS6 (See protein sequence)
Recommended Name: Synaptopodin-2  
Size: 1093 amino acids; 117514 Da
Subunit: Interacts with actin (By similarity)
Secondary accessions: B2RWP6 B2Y8J9 Q9UK89 S5XAM4
Alternative splicing: 4 isoforms:  Q9UMS6-1   Q9UMS6-2   Q9UMS6-3   Q9UMS6-4   

Explore the universe of human proteins at neXtProt for SYNPO2: NX_Q9UMS6

Explore proteomics data for SYNPO2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SYNPO2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001122405.1  NP_001122406.1  NP_001273683.1  NP_001273684.1  NP_597734.2  

    ENSEMBL proteins: 
     ENSP00000306015   ENSP00000395143   ENSP00000390965   ENSP00000425496   ENSP00000412623  

    SYNPO2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for SYNPO2
    GenScript Custom Purified and Recombinant Proteins Services for SYNPO2
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SYNPO2

    SYNPO2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for SYNPO2
    OriGene Custom Antibody Services for SYNPO2
    Novus Biologicals SYNPO2 Antibody
    Abcam antibodies for SYNPO2
    Cloud-Clone Corp. Antibodies for SYNPO2
    ThermoFisher Antibodies for SYNPO2
    LSBio Antibodies in human, mouse, rat for SYNPO2

    SYNPO2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SYNPO2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SYNPO2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SYNPO2
    Cloud-Clone Corp. CLIAs for SYNPO2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR001478 PDZ

    Graphical View of Domain Structure for InterPro Entry Q9UMS6

    ProtoNet protein and cluster: Q9UMS6

    1 Blocks protein domain: IPB001478 PDZ/DHR/GLGF domain

    UniProtKB/Swiss-Prot: SYNP2_HUMAN, Q9UMS6
    Similarity: Belongs to the synaptopodin family
    Similarity: Contains 1 PDZ (DHR) domain


    SYNPO2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SYNP2_HUMAN, Q9UMS6
    Function: Has an actin-binding and actin-bundling activity (By similarity)
    Induction: Down-regulated in muscle cell lines derived from patients with Duchenne muscular dystrophy (DMD)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005515protein binding IPI--
    GO:0051371muscle alpha-actinin binding ISS--
    GO:007188914-3-3 protein binding ISS--
         
    SYNPO2 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Synpo2 (no phenotypes)

    SYNPO2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SYNPO2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SYNPO2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SYNPO2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SYNPO2

    miRNA
    Products:
        
    miRTarBase miRNAs that target SYNPO2:
    hsa-mir-335-5p (MIRT016748)

    Block miRNA regulation of human, mouse, rat SYNPO2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SYNPO2 (see all 98):
    hsa-miR-411* hsa-miR-576-3p hsa-miR-549 hsa-miR-642a hsa-miR-607 hsa-miR-520e hsa-miR-200a hsa-miR-578
    SwitchGear 3'UTR luciferase reporter plasmidSYNPO2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SYNPO2
    Predesigned siRNA for gene silencing in human, mouse, rat SYNPO2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SYNPO2

    Clone
    Products:
         
    OriGene clones in human, mouse for SYNPO2 (see all 18)
    OriGene ORF clones in mouse, rat for SYNPO2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SYNPO2 (NM_024875)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SYNPO2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYNPO2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SYNPO2
    Browse ESI BIO Cell Lines and PureStem Progenitors for SYNPO2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYNPO2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    SYNP2_HUMAN, Q9UMS6: Nucleus (By similarity). Cytoplasm (By similarity). Note=Shuttles between the nucleus and
    the cytoplasm in a differentiation-dependent and stress-induced fashion. Localizes to the Z-disk in mature
    striated muscle. The nuclear export is XPO1-dependent (By similarity). Localized in a fiber-like pattern. partly
    overlapping with filamentous actin
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton4
    nucleus4
    cytosol3
    golgi apparatus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0015629actin cytoskeleton IDA--
    GO:0030018Z disc ISS--

    SYNPO2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SYNPO2
    Interactions:

        GeneGlobe Interaction Network for SYNPO2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for SYNPO2 (Q9UMS61, 2, 3 ENSP000003060154) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ILKQ134181, ENSP000002994214EBI-3453434,EBI-747644 STRING: ENSP00000299421
    YWHAGP619813, ENSP000003063304I2D: score=3 STRING: ENSP00000306330
    YWHAZP631043, ENSP000003095034I2D: score=2 STRING: ENSP00000309503
    WNK1Q9H4A33, ENSP000003130594I2D: score=1 STRING: ENSP00000313059
    YWHABP319463, ENSP000003001614I2D: score=1 STRING: ENSP00000300161
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SYNPO2 (SYNP2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for SYNPO2 gene (5 alternative transcripts): 
    NM_001128933.2  NM_001128934.2  NM_001286754.1  NM_001286755.1  NM_133477.2  

    Unigene Cluster for SYNPO2:

    Synaptopodin 2
    Hs.655519  [show with all ESTs]
    Unigene Representative Sequence: NM_001128933
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000307142(uc010inb.3 uc011cgh.2 uc010inc.3) ENST00000429713(uc003icm.4)
    ENST00000434046(uc010ina.3) ENST00000504178 ENST00000448416
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SYNPO2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SYNPO2 (see all 98):
    hsa-miR-411* hsa-miR-576-3p hsa-miR-549 hsa-miR-642a hsa-miR-607 hsa-miR-520e hsa-miR-200a hsa-miR-578
    SwitchGear 3'UTR luciferase reporter plasmidSYNPO2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SYNPO2
    Predesigned siRNA for gene silencing in human, mouse, rat SYNPO2
    Clone
    Products:
         
    OriGene clones in human, mouse for SYNPO2 (see all 18)
    OriGene ORF clones in mouse, rat for SYNPO2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SYNPO2 (NM_024875)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SYNPO2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYNPO2
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for SYNPO2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SYNPO2
      QuantiTect SYBR Green Assays in human, mouse, rat SYNPO2
      QuantiFast Probe-based Assays in human, mouse, rat SYNPO2

    Additional mRNA sequence: 

    AF177291.1 AJ010482.1 AK000774.1 AK021484.1 AK296962.1 AK304121.1 AK307711.1 AL832031.1 
    AL832363.1 AL833294.1 AL833547.1 BC136256.1 BC150629.1 BX647849.1 BX648090.1 CR936673.1 
    EU481975.1 FN422000.1 

    10 DOTS entries:

    DT.115185  DT.111063  DT.100659438  DT.413193  DT.91734350  DT.95151623  DT.75176385  DT.100687565 
    DT.121239608  DT.97822370 

    Selected AceView cDNA sequences (see all 361):

    AI335896 BX470987 AW469406 BE326453 AA468894 AW292003 BF057516 AI696716 
    F28522 BF109968 Z38688 AI969816 AA631771 AA112998 BE222491 AI128071 
    AI266109 BE646185 AL702162 AI659702 AA043596 AI418778 BE048902 AI743706 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    SYNPO2 expression in normal human tissues (normalized intensities)      SYNPO2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTTTGAAAT
    SYNPO2 Expression
    About this image


    SYNPO2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 19) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Adult Endothelial Cells Blood Brain Barrier
             Cerebral Cortex
     
     Placenta (Extraembryonic Tissues)    fully expand to see all 2 entries
             Placenta-derived mesenchymal stem cells (family)
     
     Mesenchymal Stem Cells (Uncategorized)    fully expand to see all 2 entries
             Placenta-derived mesenchymal stem cells (family)
     
     Lower Urinary Tract (Urinary System)
             Ureter
     
     Eye (Sensory Organs)
             Mature Rod Cells Outer Nuclear Layer
    SYNPO2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SYNPO2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.655519

    UniProtKB/Swiss-Prot: SYNP2_HUMAN, Q9UMS6
    Tissue specificity: Skeletal muscle specific

        Custom PCR Arrays for SYNPO2
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for SYNPO2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SYNPO2
    QuantiTect SYBR Green Assays in human, mouse, rat SYNPO2
    QuantiFast Probe-based Assays in human, mouse, rat SYNPO2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYNPO2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for SYNPO2 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Synpo21 , 5 synaptopodin 21, 5 82.83(n)1
    80.34(a)1
      3 (53.80 cM)5
    1184491  NM_080451.21  NP_536699.21 
     1230765195 
    chicken
    (Gallus gallus)
    Aves SYNPO21 synaptopodin 2 66.37(n)
    60.29(a)
      428768  XM_426324.3  XP_426324.3 
    lizard
    (Anolis carolinensis)
    Reptilia SYNPO26
    synaptopodin 2
    53(a)
    1 ↔ 1
    5(140177147-140295186)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia synpo21 synaptopodin 2 59.48(n)
    50.91(a)
      101733716  XM_004911450.1  XP_004911507.1 
    zebrafish
    (Danio rerio)
    Actinopterygii SYNPO2 (2 of 2)6
    SYNPO2 (1 of 2)6
    synaptopodin 2
    41(a)
    32(a)
    1 ↔ many
    1 ↔ many
    7(72582655-72587983) ENSDARG00000079675
    1(24843964-24848670) ENSDARG00000077157


    ENSEMBL Gene Tree for SYNPO2 (if available)
    TreeFam Gene Tree for SYNPO2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for SYNPO2 gene
    SYNPO2  SYNPO2L2  
    4 SIMAP similar genes for SYNPO2 using alignment to 5 protein entries:     SYNP2_HUMAN (see all proteins):
    PDLIM7    PDLIM2    SYNPO2L    MAGI2

    SYNPO2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for SYNPO2 (see all 3737)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1899021031,2
    --119807996(+) AGTGCC/TACAAT 3 -- us2k10--------
    rs1147296561,2
    F--119808243(+) TCCAGG/ATCCTC 3 -- us2k11Minor allele frequency- A:0.01WA 118
    rs357379961,2
    C,F--119808260(+) CCTGCC/TACATC 3 -- us2k19Minor allele frequency- T:0.24NA CSA WA EA 369
    rs1821077171,2
    --119808293(+) AACTGG/TCATGT 3 -- us2k10--------
    rs2009097001,2
    --119808319(+) TGAGT-/GAGAGTG 3 -- us2k10--------
    rs715953291,2
    C--119808321(+) AGTGA-/GAGT/GAGTG
    TGT
    /GTGTGTGT
    GTGTG
    3 -- us2k11NA 2
    rs571151531,2
    C--119808322(+) GTGAG-/AG/GT 
            
    TGTGT
    3 -- us2k10--------
    rs726694961,2
    C,F--119808323(+) GTGAGT/AGTGTG 3 -- us2k12Minor allele frequency- A:0.50NA CSA 4
    rs609193681,2
    C,F--119808374(+) TGGGAT/CGGTCA 3 -- us2k16Minor allele frequency- C:0.09NA CSA WA EA 363
    rs1148286411,2
    C,F--119808487(+) ATGTAT/GGGATG 3 -- us2k11Minor allele frequency- G:0.01NA 120

    HapMap Linkage Disequilibrium report for SYNPO2 (119809996 - 119982402 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for SYNPO2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv992928CNV Deletion20482838
    esv2728225CNV Deletion23290073
    esv2728224CNV Deletion23290073
    esv2728227CNV Deletion23290073
    esv2728223CNV Deletion23290073
    esv2728226CNV Deletion23290073
    esv2728229CNV Deletion23290073
    nsv289598CNV Loss16902084
    nsv522652CNV Loss19592680
    nsv819746CNV Gain19587683

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SYNPO2
    DNA2.0 Custom Variant and Variant Library Synthesis for SYNPO2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    10 diseases for SYNPO2:    About MalaCards
    myofibrillar myopathy    duchenne muscular dystrophy    alcohol dependence    myopathy
    muscular dystrophy    sinusitis    prostate cancer    prostatitis
    cerebritis    endotheliitis


    SYNPO2 for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for SYNPO2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    bladder cancer 43.9 9 12917631 (4), 18636402 (3), 15883195 (1)
    prostate cancer 39.6 24 16979744 (7), 15111326 (5), 11696420 (2), 18371299 (1) (see all 5)
    metastasis 17.9 4 16979744 (2), 15111326 (2)
    tumors 17.7 19 15111326 (5), 16979744 (4), 12917631 (3), 19360353 (3) (see all 6)

    Genetic Association Database (GAD): SYNPO2
    Human Genome Epidemiology (HuGE) Navigator: SYNPO2 (1 document)

    Export disorders for SYNPO2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for SYNPO2 gene, integrated from 10 sources (see all 40):
    (articles sorted by number of sources associating them with SYNPO2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Differentiation and stress-dependent nuclear-cytoplasmic redistribution of myopodin, a novel actin bundling protein. (PubMed id 11673475)1, 2, 3 Weins A.... Mundel P. (J. Cell Biol. 2001)
    2. Interaction between importin 13 and myopodin suggests a nuclear import pathway for myopodin. (PubMed id 17828378)1, 3, 9 Liang J....Tao T. (Mol. Cell. Biochem. 2008)
    3. Multiple isoforms of the tumor suppressor myopodin are simultaneously transcribed in cancer cells. (PubMed id 18371299)1, 2, 9 De Ganck A....Gettemans J. (Biochem. Biophys. Res. Commun. 2008)
    4. Myopodin isoforms alter the chemokinetic response of PC3 cells in response to different migration stimuli via differential effects on Rho-ROCK signaling pathways. (PubMed id 22915763)1, 2 Kai F.... Duncan R. (Carcinogenesis 2012)
    5. A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts. (PubMed id 20332099)1, 4 Kalsi G....Riley B.P. (Hum. Mol. Genet. 2010)
    6. Expression of myopodin induces suppression of tumor growth and metastasis. (PubMed id 15111326)1, 9 Jing L....Luo J.H. (Am. J. Pathol. 2004)
    7. Tumor suppressor role for myopodin in bladder cancer: loss of nuclear expression of myopodin is cell-cycle dependent and predicts clinical outcome. (PubMed id 12917631)1, 9 Sanchez-Carbayo M....Mundel P. (Oncogene 2003)
    8. Down-regulation of myopodin expression reduces invasion and motility of PC-3 prostate cancer cells. (PubMed id 19360353)1, 9 De Ganck A....Gettemans J. (Int. J. Oncol. 2009)
    9. The Nucleo-cytoplasmic actin-binding protein CapG lacks a nuclear export sequence present in structurally related proteins. (PubMed id 12637565)1, 9 Van Impe K....Gettemans J. (J. Biol. Chem. 2003)
    10. Prostate cancer cell migration induced by myopodin isoforms is associated with formation of morphologically and biochemically distinct actin networks. (PubMed id 24005909)1 Kai F. and Duncan R. (FASEB J. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 171024 HGNC: 17732 AceView: SYNPO2 Ensembl:ENSG00000172403 euGenes: HUgn171024
    ECgene: SYNPO2 H-InvDB: SYNPO2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SYNPO2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SYNPO2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SYNPO2 gene:
    Search GeneIP for patents involving SYNPO2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for SYNPO2   OriGene RNAi products in human, mouse, rat for SYNPO2  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SYNPO2  
     OriGene qSTAR qPCR primer pairs in human, mouse for SYNPO2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for SYNPO2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SYNPO2   OriGene Custom Protein Services for SYNPO2  

     
     
     Block miRNA regulation of human, mouse, rat SYNPO2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SYNPO2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SYNPO2 Predesigned siRNA for gene silencing in human, mouse, rat SYNPO2
     QuantiFast Probe-based Assays in human, mouse, rat SYNPO2 QuantiTect SYBR Green Assays in human, mouse, rat SYNPO2
     Custom PCR Arrays for SYNPO2 Search Chromatin IP Primers for SYNPO2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SYNPO2  GeneGlobe Interaction Network for SYNPO2
     Regulatory tfbs in SYNPO2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for SYNPO2 GenScript cDNA clones with any tag delivered in your preferred vector for SYNPO2
     GenScript Custom Assay Services for SYNPO2 GenScript Custom overexpressing Cell Line Services for SYNPO2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for SYNPO2 (SYNP2)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SYNPO2 antibodies
     Antibodies for SYNPO2
     See all of Abcam's Antibodies, Kits and Proteins for SYNPO2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for SYNPO2
     Antibodies for SYNPO2
     ELISAs for SYNPO2
     CLIAs for SYNPO2



     Browse ESI BIO Cell Lines and PureStem Progenitors for SYNPO2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYNPO2
     SwitchGear 3'UTR luciferase reporter plasmids for SYNPO2
     SwitchGear Promoter luciferase reporter plasmids for SYNPO2
     ThermoFisher Antibodies for SYNPO2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYNPO2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SYNPO2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SYNPO2
     LSBio Antibodies in human, mouse, rat for SYNPO2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SYNPO2 gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4