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Aliases for SYNPO2 Gene

Aliases for SYNPO2 Gene

  • Synaptopodin 2 2 3
  • Genethonin-2 3 4
  • Myopodin 3 4
  • Synaptopodin-2 3

External Ids for SYNPO2 Gene

Previous GeneCards Identifiers for SYNPO2 Gene

  • GC04P120706
  • GC04P120090
  • GC04P120203
  • GC04P120269
  • GC04P120270
  • GC04P120167
  • GC04P119809
  • GC04P115532

Summaries for SYNPO2 Gene

GeneCards Summary for SYNPO2 Gene

SYNPO2 (Synaptopodin 2) is a Protein Coding gene. GO annotations related to this gene include actin binding and muscle alpha-actinin binding. An important paralog of this gene is SYNPO2L.

UniProtKB/Swiss-Prot for SYNPO2 Gene

  • Has an actin-binding and actin-bundling activity.

Gene Wiki entry for SYNPO2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYNPO2 Gene

Genomics for SYNPO2 Gene

Regulatory Elements for SYNPO2 Gene

Genomic Location for SYNPO2 Gene

118,850,688 bp from pter
119,061,247 bp from pter
210,560 bases
Plus strand

Genomic View for SYNPO2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SYNPO2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYNPO2 Gene

Proteins for SYNPO2 Gene

  • Protein details for SYNPO2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B2RWP6
    • B2Y8J9
    • Q9UK89
    • S5XAM4

    Protein attributes for SYNPO2 Gene

    1093 amino acids
    Molecular mass:
    117514 Da
    Quaternary structure:
    • Interacts with actin.

    Alternative splice isoforms for SYNPO2 Gene


neXtProt entry for SYNPO2 Gene

Proteomics data for SYNPO2 Gene at MOPED

Post-translational modifications for SYNPO2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SYNPO2 Gene

Domains for SYNPO2 Gene

Protein Domains for SYNPO2 Gene


Suggested Antigen Peptide Sequences for SYNPO2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 PDZ (DHR) domain.
  • Belongs to the synaptopodin family.
  • Contains 1 PDZ (DHR) domain.
  • Belongs to the synaptopodin family.
genes like me logo Genes that share domains with SYNPO2: view

No data available for Gene Families for SYNPO2 Gene

Function for SYNPO2 Gene

Molecular function for SYNPO2 Gene

UniProtKB/Swiss-Prot Function:
Has an actin-binding and actin-bundling activity.
UniProtKB/Swiss-Prot Induction:
Down-regulated in muscle cell lines derived from patients with Duchenne muscular dystrophy (DMD).

Gene Ontology (GO) - Molecular Function for SYNPO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005515 protein binding IPI 21643011
GO:0051371 muscle alpha-actinin binding ISS --
GO:0071889 14-3-3 protein binding ISS --
genes like me logo Genes that share ontologies with SYNPO2: view

Animal Model Products

miRNA for SYNPO2 Gene

miRTarBase miRNAs that target SYNPO2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SYNPO2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SYNPO2 Gene

Localization for SYNPO2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYNPO2 Gene

Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm in a differentiation-dependent and stress-induced fashion. Localizes to the Z-disk in mature striated muscle. The nuclear export is XPO1-dependent (By similarity). Localized in a fiber-like pattern. partly overlapping with filamentous actin. {ECO:0000250, ECO:0000269 PubMed:18371299}.

Subcellular locations from

Jensen Localization Image for SYNPO2 Gene COMPARTMENTS Subcellular localization image for SYNPO2 gene
Compartment Confidence
cytoskeleton 4
nucleus 4
cytosol 3
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SYNPO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005925 focal adhesion IDA 21423176
GO:0015629 actin cytoskeleton IDA --
GO:0030018 Z disc ISS --
genes like me logo Genes that share ontologies with SYNPO2: view

Pathways for SYNPO2 Gene

SuperPathways for SYNPO2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SYNPO2 Gene


No data available for Pathways by source for SYNPO2 Gene

Transcripts for SYNPO2 Gene

Unigene Clusters for SYNPO2 Gene

Synaptopodin 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SYNPO2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SYNPO2 Gene

No ASD Table

Relevant External Links for SYNPO2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SYNPO2 Gene

mRNA expression in normal human tissues for SYNPO2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SYNPO2 Gene

This gene is overexpressed in Muscle - Skeletal (12.5), Esophagus - Muscularis (5.9), Colon - Sigmoid (4.3), and Artery - Tibial (4.2).

Protein differential expression in normal tissues for SYNPO2 Gene

This gene is overexpressed in Colon muscle (12.1), Prostate (10.8), Rectum (7.7), Urinary Bladder (7.3), Colon (6.6), and Seminal vesicle (6.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SYNPO2 Gene

SOURCE GeneReport for Unigene cluster for SYNPO2 Gene Hs.655519

mRNA Expression by UniProt/SwissProt for SYNPO2 Gene

Tissue specificity: Skeletal muscle specific.
genes like me logo Genes that share expressions with SYNPO2: view

Expression partners for SYNPO2 Gene

* - Elite partner

Primer Products

In Situ Assay Products

Orthologs for SYNPO2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SYNPO2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SYNPO2 35
  • 86.54 (n)
  • 85.75 (a)
  • 86 (a)
(Canis familiaris)
Mammalia SYNPO2 35
  • 82.33 (n)
  • 80.98 (a)
  • 81 (a)
(Mus musculus)
Mammalia Synpo2 35
  • 82.83 (n)
  • 80.34 (a)
Synpo2 16
Synpo2 36
  • 80 (a)
(Pan troglodytes)
Mammalia SYNPO2 35
  • 99.58 (n)
  • 99.21 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Synpo2 35
  • 81.76 (n)
  • 78.19 (a)
(Monodelphis domestica)
Mammalia SYNPO2 36
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia SYNPO2 36
  • 62 (a)
(Gallus gallus)
Aves SYNPO2 35
  • 66.37 (n)
  • 60.29 (a)
  • 55 (a)
(Anolis carolinensis)
Reptilia SYNPO2 36
  • 53 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia synpo2 35
  • 59.48 (n)
  • 50.91 (a)
(Danio rerio)
Actinopterygii SYNPO2 (1 of 2) 36
  • 32 (a)
SYNPO2 (2 of 2) 36
  • 41 (a)
Species with no ortholog for SYNPO2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SYNPO2 Gene

Gene Tree for SYNPO2 (if available)
Gene Tree for SYNPO2 (if available)

Paralogs for SYNPO2 Gene

Paralogs for SYNPO2 Gene

(4) SIMAP similar genes for SYNPO2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SYNPO2: view

Variants for SYNPO2 Gene

Sequence variations from dbSNP and Humsavar for SYNPO2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs1846 -- 118,981,925(-) CTGAA(C/T)GCAAA intron-variant
rs1847 -- 118,981,909(-) TTTCC(A/G)TCCAG intron-variant
rs10103 -- 119,035,530(+) TGTCA(C/T)TCTAG utr-variant-3-prime, intron-variant
rs13837 -- 119,033,378(+) AACTT(G/T)AATTG utr-variant-3-prime, intron-variant
rs25613 -- 119,060,454(+) GGGTA(-/TTC)TTCTC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SYNPO2 Gene

Variant ID Type Subtype PubMed ID
nsv289598 CNV Loss 16902084
esv2728223 CNV Deletion 23290073
esv2728224 CNV Deletion 23290073
esv2728225 CNV Deletion 23290073
esv2728226 CNV Deletion 23290073
esv2728227 CNV Deletion 23290073
esv2728229 CNV Deletion 23290073
esv992928 CNV Deletion 20482838
nsv522652 CNV Loss 19592680
nsv819746 CNV Gain 19587683

Relevant External Links for SYNPO2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SYNPO2 Gene

Disorders for SYNPO2 Gene

(4) Novoseek inferred disease relationships for SYNPO2 Gene

Disease -log(P) Hits PubMed IDs
bladder cancer 43.9 8
prostate cancer 39.6 16
metastasis 17.9 4
tumors 17.7 17

Relevant External Links for SYNPO2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with SYNPO2: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for SYNPO2 Gene

Publications for SYNPO2 Gene

  1. Multiple isoforms of the tumor suppressor myopodin are simultaneously transcribed in cancer cells. (PMID: 18371299) De Ganck A. … Gettemans J. (Biochem. Biophys. Res. Commun. 2008) 3 4 23
  2. Differentiation and stress-dependent nuclear-cytoplasmic redistribution of myopodin, a novel actin bundling protein. (PMID: 11673475) Weins A. … Mundel P. (J. Cell Biol. 2001) 2 3 4
  3. Interaction between importin 13 and myopodin suggests a nuclear import pathway for myopodin. (PMID: 17828378) Liang J. … Tao T. (Mol. Cell. Biochem. 2008) 2 3 23
  4. Down-regulation of myopodin expression reduces invasion and motility of PC-3 prostate cancer cells. (PMID: 19360353) De Ganck A. … Gettemans J. (Int. J. Oncol. 2009) 3 23
  5. The Nucleo-cytoplasmic actin-binding protein CapG lacks a nuclear export sequence present in structurally related proteins. (PMID: 12637565) Van Impe K. … Gettemans J. (J. Biol. Chem. 2003) 3 23

Products for SYNPO2 Gene

Sources for SYNPO2 Gene

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