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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SYNPO2 Gene

protein-coding   GIFtS: 53
GCID: GC04P119809

Synaptopodin 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Synaptopodin 21 2     synaptopodin-22
Genethonin 22     Genethonin-23
genethonin-22     Myopodin3
myopodin2     

External Ids:    HGNC: 177321   Entrez Gene: 1710242   Ensembl: ENSG000001724037   UniProtKB: Q9UMS63   

Export aliases for SYNPO2 gene to outside databases

Previous GC identifers: GC04P120706 GC04P120090 GC04P120203 GC04P120269 GC04P120270 GC04P120167 GC04P115532


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SYNPO2 Gene: 
SYNPO2 (synaptopodin 2) is a protein-coding gene. Diseases associated with SYNPO2 include myofibrillar myopathy, and duchenne muscular dystrophy. GO annotations related to this gene include muscle alpha-actinin binding and actin binding. An important paralog of this gene is SYNPO.

UniProtKB/Swiss-Prot: SYNP2_HUMAN, Q9UMS6
Function: Has an actin-binding and actin-bundling activity (By similarity)

Gene Wiki entry for SYNPO2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.2  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SYNPO2 gene promoter:
         TBP   Pax-5   ATF-2   MIF-1   C/EBPalpha   CRE-BP1   CHOP-10   TFIID   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SYNPO2 promoter sequence
   Search SABiosciences Chromatin IP Primers for SYNPO2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SYNPO2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q26   Ensembl cytogenetic band:  4q26   HGNC cytogenetic band: 4q26

SYNPO2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SYNPO2 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P119809:  view genomic region     (about GC identifiers)

Start:
119,809,996 bp from pter      End:
119,982,402 bp from pter
Size:
172,407 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SYNP2_HUMAN, Q9UMS6 (See protein sequence)
Recommended Name: Synaptopodin-2  
Size: 1093 amino acids; 117514 Da
Subunit: Interacts with actin (By similarity)
Subcellular location: Nucleus (By similarity). Cytoplasm (By similarity). Note=Shuttles between the nucleus and
the cytoplasm in a differentiation-dependent and stress-induced fashion. Localizes to the Z-disk in mature
striated muscle. The nuclear export is XPO1-dependent (By similarity). Localized in a fiber-like pattern. partly
overlapping with filamentous actin
Secondary accessions: B2RWP6 B2Y8J9 Q9UK89
Alternative splicing: 3 isoforms:  Q9UMS6-1   Q9UMS6-2   Q9UMS6-3   

Explore the universe of human proteins at neXtProt for SYNPO2: NX_Q9UMS6

Explore proteomics data for SYNPO2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UMS6

  • SYNPO2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SYNPO2 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001122405.1  NP_001122406.1  NP_597734.2  

    ENSEMBL proteins: 
     ENSP00000306015   ENSP00000395143   ENSP00000390965   ENSP00000425496   ENSP00000412623  

    Human Recombinant Protein Products for SYNPO2: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SYNPO2 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0015629actin cytoskeleton IDA--
    GO:0030018Z disc ISS--

    SYNPO2 for ontologies           About GeneDecksing



    SYNPO2 Antibody Products: 
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    Cloud-Clone Corp. ELISAs for SYNPO2 
    Cloud-Clone Corp. CLIAs for SYNPO2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR001478 PDZ

    Graphical View of Domain Structure for InterPro Entry Q9UMS6

    ProtoNet protein and cluster: Q9UMS6

    1 Blocks protein domain: IPB001478 PDZ/DHR/GLGF domain

    UniProtKB/Swiss-Prot: SYNP2_HUMAN, Q9UMS6
    Similarity: Belongs to the synaptopodin family
    Similarity: Contains 1 PDZ (DHR) domain


    SYNPO2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SYNP2_HUMAN, Q9UMS6
    Function: Has an actin-binding and actin-bundling activity (By similarity)
    Induction: Down-regulated in muscle cell lines derived from patients with Duchenne muscular dystrophy (DMD)

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005515protein binding IPI--
    GO:0051371muscle alpha-actinin binding ISS--
    GO:007188914-3-3 protein binding ISS--
         
    SYNPO2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SYNPO2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SYNPO2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SYNPO2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SYNPO2 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SYNPO2
    8/98 QIAGEN miScript miRNA Assays for microRNAs that regulate SYNPO2 (see all 98):
    hsa-miR-411* hsa-miR-576-3p hsa-miR-549 hsa-miR-642a hsa-miR-607 hsa-miR-520e hsa-miR-200a hsa-miR-578
    SwitchGear 3'UTR luciferase reporter plasmidSYNPO2 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Clone
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYNPO2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SYNPO2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/8 Interacting proteins for SYNPO2 (Q9UMS61, 2, 3 ENSP000003060154) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ILKQ134181, ENSP000002994214EBI-3453434,EBI-747644 STRING: ENSP00000299421
    YWHAGP619813, ENSP000003063304I2D: score=3 STRING: ENSP00000306330
    YWHAZP631043, ENSP000003095034I2D: score=2 STRING: ENSP00000309503
    WNK1Q9H4A33, ENSP000003130594I2D: score=1 STRING: ENSP00000313059
    YWHABP319463I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SYNPO2 (SYNP2)

    Search CenterWatch for drugs/clinical trials and news about SYNPO2 / SYNP2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SYNPO2 gene (3 alternative transcripts): 
    NM_001128933.1  NM_001128934.1  NM_133477.2  

    Unigene Cluster for SYNPO2:

    Synaptopodin 2
    Hs.655519  [show with all ESTs]
    Unigene Representative Sequence: NM_001128933
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000307142(uc010inb.3 uc011cgh.2 uc010inc.3) ENST00000429713(uc003icm.4)
    ENST00000434046(uc010ina.3) ENST00000504178 ENST00000448416
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SYNPO2
    8/98 QIAGEN miScript miRNA Assays for microRNAs that regulate SYNPO2 (see all 98):
    hsa-miR-411* hsa-miR-576-3p hsa-miR-549 hsa-miR-642a hsa-miR-607 hsa-miR-520e hsa-miR-200a hsa-miR-578
    SwitchGear 3'UTR luciferase reporter plasmidSYNPO2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SYNPO2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SYNPO2
    Clone
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    OriGene clones in human, mouse for SYNPO2 (see all 13)
    OriGene ORF clones in mouse, rat for SYNPO2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SYNPO2 (NM_024875)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SYNPO2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYNPO2
    Sirion Biotech Customized lentivirus for stable overexpression of SYNPO2 
                         Customized lentivirus expression plasmids for stable overexpression of SYNPO2 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for SYNPO2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SYNPO2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SYNPO2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SYNPO2

    Additional mRNA sequence: 

    AF177291.1 AJ010482.1 AK000774.1 AK021484.1 AK296962.1 AK304121.1 AK307711.1 AL832031.1 
    AL832363.1 AL833294.1 AL833547.1 BC136256.1 BC150629.1 BX647849.1 BX648090.1 CR936673.1 
    EU481975.1 FN422000.1 

    10 DOTS entries:

    DT.115185  DT.111063  DT.100659438  DT.413193  DT.91734350  DT.95151623  DT.75176385  DT.100687565 
    DT.121239608  DT.97822370 

    24/361 AceView cDNA sequences (see all 361):

    Z38688 AI335896 BX470987 AW082507 AK000774 AI886177 BX646256 BX489706 
    AI745570 BX471306 AA555266 AA256538 AI277460 D62928 AI339022 W58286 
    AW469406 BE326453 AA468894 AW292003 BF057516 AI696716 F28522 BF109968 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SYNPO2 expression in normal human tissues (normalized intensities)      SYNPO2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTTTGAAAT
    SYNPO2 Expression
    About this image


    SYNPO2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/20 selected tissues (see all 20) fully expand
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 5 entries
             Ureter
             visceral organ   
     
     Kidney (Urinary System)    fully expand to see all 4 entries
             Metanephros
             kidney ; cells in glomeruli   
             visceral organ/metanephros/pelvis   
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             skeletal muscle ; myocytes   
             vastus lateralis   
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Adult Endothelial Cells Blood Brain Barrier
             Cerebral Cortex
     
     Placenta (Extraembryonic Tissues)    fully expand to see all 2 entries
             Decidua-derived mesenchymal cells
             placenta ; decidual cells   

    See SYNPO2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SYNPO2

    SOURCE GeneReport for Unigene cluster: Hs.655519

    UniProtKB/Swiss-Prot: SYNP2_HUMAN, Q9UMS6
    Tissue specificity: Skeletal muscle specific

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYNPO2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for SYNPO2 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Synpo21 , 5 synaptopodin 21, 5 82.93(n)1
    80.58(a)1
      3 (53.80 cM)5
    1184491  NM_080451.21  NP_536699.21 
     1230765195 
    chicken
    (Gallus gallus)
    Aves SYNPO21 synaptopodin 2 66.31(n)
    60.39(a)
      428768  XM_426324.2  XP_426324.2 
    lizard
    (Anolis carolinensis)
    Reptilia SYNPO26
    Uncharacterized protein
    57(a)
    1 ↔ 1
    5(140177147-140295186)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5705261 uncharacterized LOC570526 51.3(n)
    44.2(a)
      570526  XM_694019.5  XP_699111.5 


    ENSEMBL Gene Tree for SYNPO2 (if available)
    TreeFam Gene Tree for SYNPO2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SYNPO2 gene
    SYNPO2  SYNPO2L2  
    5 SIMAP similar genes for SYNPO2 using alignment to 5 protein entries:     SYNP2_HUMAN (see all proteins):
    PDLIM5    PDLIM7    PDLIM2    SYNPO2L    MAGI2

    SYNPO2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3737 SNPs in SYNPO2 are shown (see all 3737)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1899021031,2
    --119807996(+) AGTGCC/TACAAT 3 -- us2k10--------
    rs1147296561,2
    F--119808243(+) TCCAGG/ATCCTC 3 -- us2k11Minor allele frequency- A:0.01WA 118
    rs357379961,2
    C,F--119808260(+) CCTGCC/TACATC 3 -- us2k19Minor allele frequency- T:0.24NA CSA WA EA 369
    rs1821077171,2
    --119808293(+) AACTGG/TCATGT 3 -- us2k10--------
    rs2009097001,2
    --119808319(+) TGAGT-/GAGAGTG 3 -- us2k10--------
    rs715953291,2
    C--119808321(+) AGTGA-/GAGT/GAGTG
    TGT
    /GTGTGTGT
    GTGTG
    3 -- us2k11NA 2
    rs571151531,2
    C--119808322(+) GTGAG-/AG/GT 
            
    TGTGT
    3 -- us2k10--------
    rs726694961,2
    C,F--119808323(+) GTGAGT/AGTGTG 3 -- us2k12Minor allele frequency- A:0.50NA CSA 4
    rs609193681,2
    C,F--119808374(+) TGGGAT/CGGTCA 3 -- us2k16Minor allele frequency- C:0.09NA CSA WA EA 363
    rs1148286411,2
    C,F--119808487(+) ATGTAT/GGGATG 3 -- us2k11Minor allele frequency- G:0.01NA 120

    HapMap Linkage Disequilibrium report for SYNPO2 (119809996 - 119982402 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for SYNPO2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv992928CNV Deletion20482838
    esv2728225CNV Deletion23290073
    esv2728224CNV Deletion23290073
    esv2728227CNV Deletion23290073
    esv2728223CNV Deletion23290073
    esv2728226CNV Deletion23290073
    esv2728229CNV Deletion23290073
    nsv289598CNV Loss16902084
    nsv522652CNV Loss19592680
    nsv819746CNV Gain19587683

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SYNPO2
    DNA2.0 Custom Variant and Variant Library Synthesis for SYNPO2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    9 diseases for SYNPO2:    About MalaCards
    myofibrillar myopathy    duchenne muscular dystrophy    alcohol dependence    myopathy
    muscular dystrophy    alcoholism    prostate cancer    prostatitis
    colon cancer


    SYNPO2 for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for SYNPO2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    bladder cancer 43.9 9 12917631 (4), 18636402 (3), 15883195 (1)
    prostate cancer 39.6 24 16979744 (7), 15111326 (5), 11696420 (2), 18371299 (1) (see all 5)
    metastasis 17.9 4 16979744 (2), 15111326 (2)
    tumors 17.7 19 15111326 (5), 16979744 (4), 12917631 (3), 19360353 (3) (see all 6)

    Genetic Association Database (GAD): SYNPO2
    Human Genome Epidemiology (HuGE) Navigator: SYNPO2 (1 document)

    Export disorders for SYNPO2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SYNPO2 gene, integrated from 9 sources (see all 36):
    (articles sorted by number of sources associating them with SYNPO2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Differentiation and stress-dependent nuclear-cytoplasmic redistribution of myopodin, a novel actin bundling protein. (PubMed id 11673475)1, 2, 3 Weins A.... Mundel P. (2001)
    2. Interaction between importin 13 and myopodin suggests a nuclear import pathway for myopodin. (PubMed id 17828378)1, 3, 9 Liang J....Tao T. (2008)
    3. Multiple isoforms of the tumor suppressor myopodin are simultaneously transcribed in cancer cells. (PubMed id 18371299)1, 2, 9 De Ganck A....Gettemans J. (2008)
    4. A systematic gene-based screen of chr4q22-q32 identif ies association of a novel susceptibility gene, DKK2, with the quantitative tra it of alcohol dependence symptom counts. (PubMed id 20332099)1, 4 Kalsi G....Riley B.P. (2010)
    5. Expression of myopodin induces suppression of tumor growth and metastasis. (PubMed id 15111326)1, 9 Jing L....Luo J.H. (2004)
    6. Tumor suppressor role for myopodin in bladder cancer: loss of nuclear expression of myopodin is cell-cycle dependent and predicts clinical outcome. (PubMed id 12917631)1, 9 Sanchez-Carbayo M....Mundel P. (2003)
    7. Down-regulation of myopodin expression reduces invasion and motility of PC-3 prostate cancer cells. (PubMed id 19360353)1, 9 De Ganck A....Gettemans J. (2009)
    8. The Nucleo-cytoplasmic actin-binding protein CapG lacks a nuclear export sequence present in structurally related proteins. (PubMed id 12637565)1, 9 Van Impe K....Gettemans J. (2003)
    9. Cellular mechanotransduction relies on tension-induced and chaperone-assisted autophagy. (PubMed id 23434281)1 Ulbricht A....Hohfeld J. (2013)
    10. Diagnostic and prognostic utility of methylation and p rotein expression patterns of myopodin in colon cancer. (PubMed id 22252522)1 Esteban S....Sanchez-Carbayo M. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 171024 HGNC: 17732 AceView: SYNPO2 Ensembl:ENSG00000172403 euGenes: HUgn171024
    ECgene: SYNPO2 H-InvDB: SYNPO2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SYNPO2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SYNPO2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SYNPO2 gene:
    Search GeneIP for patents involving SYNPO2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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