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Aliases for SYNPO Gene

Aliases for SYNPO Gene

  • Synaptopodin 2 3 5
  • KIAA1029 4

External Ids for SYNPO Gene

Previous GeneCards Identifiers for SYNPO Gene

  • GC05P149963
  • GC05P150009
  • GC05P149960
  • GC05P145127

Summaries for SYNPO Gene

Entrez Gene Summary for SYNPO Gene

  • Synaptopodin is an actin-associated protein that may play a role in actin-based cell shape and motility. The name synaptopodin derives from the protein's associations with postsynaptic densities and dendritic spines and with renal podocytes (Mundel et al., 1997 [PubMed 9314539]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SYNPO Gene

SYNPO (Synaptopodin) is a Protein Coding gene. Diseases associated with SYNPO include membranous glomerulonephritis and crescentic glomerulonephritis. GO annotations related to this gene include actin binding. An important paralog of this gene is SYNPO2L.

UniProtKB/Swiss-Prot for SYNPO Gene

  • Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity (By similarity).

Gene Wiki entry for SYNPO Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYNPO Gene

Genomics for SYNPO Gene

Regulatory Elements for SYNPO Gene

Genomic Location for SYNPO Gene

Chromosome:
5
Start:
150,586,037 bp from pter
End:
150,659,230 bp from pter
Size:
73,194 bases
Orientation:
Plus strand

Genomic View for SYNPO Gene

Genes around SYNPO on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SYNPO Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SYNPO Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYNPO Gene

Proteins for SYNPO Gene

  • Protein details for SYNPO Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N3V7-SYNPO_HUMAN
    Recommended name:
    Synaptopodin
    Protein Accession:
    Q8N3V7
    Secondary Accessions:
    • A5PKZ8
    • D3DQG8
    • O15271
    • Q9UPX1

    Protein attributes for SYNPO Gene

    Size:
    929 amino acids
    Molecular mass:
    99463 Da
    Quaternary structure:
    • Interacts with BAIAP1. Interacts with actin (By similarity). Interacts (via PPxY motifs) with WWC1 (via WW domains).
    SequenceCaution:
    • Sequence=BAA82981.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SYNPO Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SYNPO Gene

Proteomics data for SYNPO Gene at MOPED

Post-translational modifications for SYNPO Gene

Other Protein References for SYNPO Gene

Antibody Products

No data available for DME Specific Peptides for SYNPO Gene

Domains & Families for SYNPO Gene

Protein Domains for SYNPO Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SYNPO Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N3V7

UniProtKB/Swiss-Prot:

SYNPO_HUMAN :
  • Belongs to the synaptopodin family.
Family:
  • Belongs to the synaptopodin family.
genes like me logo Genes that share domains with SYNPO: view

No data available for Gene Families for SYNPO Gene

Function for SYNPO Gene

Molecular function for SYNPO Gene

UniProtKB/Swiss-Prot Function:
Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity (By similarity).

Gene Ontology (GO) - Molecular Function for SYNPO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding ISS --
genes like me logo Genes that share ontologies with SYNPO: view
genes like me logo Genes that share phenotypes with SYNPO: view

Animal Models for SYNPO Gene

MGI Knock Outs for SYNPO:

Animal Model Products

  • Taconic Biosciences Mouse Models for SYNPO

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SYNPO Gene

Localization for SYNPO Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYNPO Gene

Cytoplasm, cytoskeleton. Cell junction, tight junction. Perikaryon. Cell projection, dendritic spine. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse. Note=Localized at the tight junction of cells. In brain, localized to the postsynaptic densities and in the perikarya. Associated with dendritic spines of a subset of synapses. {ECO:0000250 UniProtKB:Q8CC35}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SYNPO Gene COMPARTMENTS Subcellular localization image for SYNPO gene
Compartment Confidence
cytoskeleton 5
nucleus 4
plasma membrane 4
cytosol 3
extracellular 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for SYNPO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0014069 postsynaptic density IEA --
GO:0015629 actin cytoskeleton ISS --
GO:0045211 postsynaptic membrane IEA --
genes like me logo Genes that share ontologies with SYNPO: view

Pathways & Interactions for SYNPO Gene

SuperPathways for SYNPO Gene

No Data Available

Gene Ontology (GO) - Biological Process for SYNPO Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SYNPO Gene

Drugs & Compounds for SYNPO Gene

(2) Additional Compounds for SYNPO Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SYNPO: view

Transcripts for SYNPO Gene

Unigene Clusters for SYNPO Gene

Synaptopodin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SYNPO Gene

No ASD Table

Relevant External Links for SYNPO Gene

GeneLoc Exon Structure for
SYNPO
ECgene alternative splicing isoforms for
SYNPO

Expression for SYNPO Gene

mRNA expression in normal human tissues for SYNPO Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SYNPO Gene

This gene is overexpressed in Muscle - Skeletal (x9.7), Heart - Left Ventricle (x4.6), and Artery - Aorta (x4.5).

Protein differential expression in normal tissues from HIPED for SYNPO Gene

This gene is overexpressed in Brain (30.6) and Frontal cortex (14.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SYNPO Gene



SOURCE GeneReport for Unigene cluster for SYNPO Gene Hs.435228

mRNA Expression by UniProt/SwissProt for SYNPO Gene

Q8N3V7-SYNPO_HUMAN
Tissue specificity: Expressed in cerebral cortex.
genes like me logo Genes that share expression patterns with SYNPO: view

Protein tissue co-expression partners for SYNPO Gene

Primer Products

In Situ Assay Products

Orthologs for SYNPO Gene

This gene was present in the common ancestor of chordates.

Orthologs for SYNPO Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Synpo 35
  • 83.52 (n)
  • 84.2 (a)
Synpo 16
Synpo 36
  • 58 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SYNPO 35
  • 99 (n)
  • 98.78 (a)
SYNPO 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Synpo 35
  • 82.91 (n)
  • 83.66 (a)
cow
(Bos Taurus)
Mammalia SYNPO 36
  • 65 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SYNPO 36
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SYNPO 36
  • 45 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SYNPO 36
  • 44 (a)
OneToOne
chicken
(Gallus gallus)
Aves SYNPO 36
  • 39 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SYNPO 36
  • 35 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii SYNPO 36
  • 29 (a)
OneToOne
Species with no ortholog for SYNPO:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SYNPO Gene

ENSEMBL:
Gene Tree for SYNPO (if available)
TreeFam:
Gene Tree for SYNPO (if available)

Paralogs for SYNPO Gene

Paralogs for SYNPO Gene

genes like me logo Genes that share paralogs with SYNPO: view

Variants for SYNPO Gene

Sequence variations from dbSNP and Humsavar for SYNPO Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs28197 -- 150,658,503(-) GGGAC(C/T)TGAAT utr-variant-3-prime
rs28298 -- 150,658,236(-) TTCAA(A/G)CCCAA utr-variant-3-prime
rs40310 -- 150,616,653(-) CAGGG(A/C)GATGA intron-variant, upstream-variant-2KB
rs33409 -- 150,658,703(-) CACCC(C/T)GGTAA utr-variant-3-prime
rs33411 -- 150,650,668(-) GCAAG(A/G)CGCTG intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SYNPO Gene

Variant ID Type Subtype PubMed ID
dgv1862e1 CNV Complex 17122850
nsv5063 CNV Loss 18451855
nsv5064 CNV Insertion 18451855
nsv428129 CNV Loss 18775914
esv33898 CNV Loss 17666407

Variation tolerance for SYNPO Gene

Residual Variation Intolerance Score: 48.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.78; 79.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SYNPO Gene

HapMap Linkage Disequilibrium report
SYNPO
Human Gene Mutation Database (HGMD)
SYNPO

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SYNPO Gene

Disorders for SYNPO Gene

MalaCards: The human disease database

(10) MalaCards diseases for SYNPO Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
membranous glomerulonephritis
  • membranous nephropathy
crescentic glomerulonephritis
  • idiopathic crescentic glomerulonephritis
pauci-immune glomerulonephritis
nephrosclerosis
  • renal sclerosis
galloway-mowat syndrome
  • galloway syndrome
- elite association - COSMIC cancer census association via MalaCards
Search SYNPO in MalaCards View complete list of genes associated with diseases

Relevant External Links for SYNPO

Genetic Association Database (GAD)
SYNPO
Human Genome Epidemiology (HuGE) Navigator
SYNPO
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SYNPO
genes like me logo Genes that share disorders with SYNPO: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SYNPO Gene

Publications for SYNPO Gene

  1. Synaptopodin: an actin-associated protein in telencephalic dendrites and renal podocytes. (PMID: 9314539) Mundel P. … Kriz W. (J. Cell Biol. 1997) 2 3 4 23 67
  2. Functional analysis of promoter mutations in the ACTN4 and SYNPO genes in focal segmental glomerulosclerosis. (PMID: 19666657) Dai S. … Chen N. (Nephrol. Dial. Transplant. 2010) 3 23
  3. Glomerular expression of nephrin and synaptopodin, but not podocin, is decreased in kidney sections from women with preeclampsia. (PMID: 17255128) Garovic V.D. … Grande J.P. (Nephrol. Dial. Transplant. 2007) 3 23
  4. Expression of synaptopodin and GLEPP1 as markers of steroid responsiveness in primary focal segmental glomerulosclerosis. (PMID: 16564554) Hirakawa M. … Iida M. (Life Sci. 2006) 3 23
  5. Synaptopodin orchestrates actin organization and cell motility via regulation of RhoA signalling. (PMID: 16622418) Asanuma K. … Mundel P. (Nat. Cell Biol. 2006) 3 23

Products for SYNPO Gene

Sources for SYNPO Gene

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