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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SYNPO Gene

protein-coding   GIFtS: 54
GCID: GC05P149960

Synaptopodin

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
synaptopodin1 2
KIAA10293

External Ids:    HGNC: 306721   Entrez Gene: 113462   Ensembl: ENSG000001719927   OMIM: 6081555   UniProtKB: Q8N3V73   

Export aliases for SYNPO gene to outside databases

Previous GC identifers: GC05P149963 GC05P150009 GC05P145127


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SYNPO Gene:
Synaptopodin is an actin-associated protein that may play a role in actin-based cell shape and motility. The name
synaptopodin derives from the protein's associations with postsynaptic densities and dendritic spines and with
renal podocytes (Mundel et al., 1997 (PubMed 9314539)).(supplied by OMIM, Mar 2008)

GeneCards Summary for SYNPO Gene: 
SYNPO (synaptopodin) is a protein-coding gene. Diseases associated with SYNPO include pauci-immune glomerulonephritis, and crescentic glomerulonephritis. GO annotations related to this gene include protein binding and actin binding. An important paralog of this gene is SYNPO2.

UniProtKB/Swiss-Prot: SYNPO_HUMAN, Q8N3V7
Function: Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic
spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines
of telencephalic neurons, which is involved in synaptic plasticity (By similarity)

Gene Wiki entry for SYNPO Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NT_029289.11  NC_018916.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SYNPO gene promoter:
         NF-1   AML1a   p53   MyoD   Olf-1   MEF-2A   Msx-1   aMEF-2   Zic3   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSYNPO promoter sequence
   Search SABiosciences Chromatin IP Primers for SYNPO

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SYNPO


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q33.1   Ensembl cytogenetic band:  5q33.1   HGNC cytogenetic band: 5q33.1

SYNPO Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SYNPO gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P149960:  view genomic region     (about GC identifiers)

Start:
149,980,642 bp from pter      End:
150,038,792 bp from pter
Size:
58,151 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SYNPO_HUMAN, Q8N3V7 (See protein sequence)
Recommended Name: Synaptopodin  
Size: 929 amino acids; 99463 Da
Subunit: Interacts with BAIAP1. Interacts with actin (By similarity). Interacts (via PPxY motifs) with WWC1 (via
WW domains)
Subcellular location: Cytoplasm, cytoskeleton (By similarity). Cell junction, tight junction (By similarity).
Perikaryon (By similarity). Cell projection, dendritic spine (By similarity). Cell junction, synapse,
postsynaptic cell membrane, postsynaptic density (By similarity). Cell junction, synapse (By similarity).
Note=Localized at the tight junction of cells. In brain, localized to the postsynaptic densities and in the
perikarya. Associated with dendritic spines of a subset of synapses (By similarity)
Sequence caution: Sequence=BAA82981.2; Type=Erroneous initiation;
Secondary accessions: A5PKZ8 D3DQG8 O15271 Q9UPX1
Alternative splicing: 3 isoforms:  Q8N3V7-1   Q8N3V7-2   Q8N3V7-3   (Contains a phosphoserine at position 871. Contains a phosphoserine at position 826. Contains a phosphoserine at position 894. Contains a phosphoserine at position 854)

Explore the universe of human proteins at neXtProt for SYNPO: NX_Q8N3V7

Explore proteomics data for SYNPO at MOPED 

Post-translational modifications:

  • UniProtKB: O-glycosylated (By similarity)
  • UniProtKB: Isoform 2 is phosphorylated on Ser-826, Thr-836, Ser-840 and Ser-871
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8N3V7

  • SYNPO Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SYNPO Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001103444.1  NP_001159680.1  NP_001159681.1  NP_009217.3  

    ENSEMBL proteins: 
     ENSP00000377789   ENSP00000428378   ENSP00000302139   ENSP00000429268  

    Human Recombinant Protein Products for SYNPO: 
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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SYNPO 

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001725stress fiber IEA--
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane IEA--
    GO:0005923tight junction IEA--
    GO:0014069postsynaptic density IEA--

    SYNPO for ontologies           About GeneDecksing



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    Cloud-Clone Corp. ELISAs for SYNPO 
    Cloud-Clone Corp. CLIAs for SYNPO


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q8N3V7

    UniProtKB/Swiss-Prot: SYNPO_HUMAN, Q8N3V7
    Similarity: Belongs to the synaptopodin family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SYNPO_HUMAN, Q8N3V7
    Function: Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic
    spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines
    of telencephalic neurons, which is involved in synaptic plasticity (By similarity)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding ISS--
    GO:0005515protein binding IPI15841212
         
    SYNPO for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Synpo):
     behavior/neurological  nervous system  renal/urinary system 

    SYNPO for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SYNPO 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SYNPO

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SYNPO 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SYNPO 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SYNPO
    8/36 QIAGEN miScript miRNA Assays for microRNAs that regulate SYNPO (see all 36):
    hsa-miR-194* hsa-miR-650 hsa-miR-759 hsa-miR-570 hsa-miR-1304 hsa-miR-548m hsa-miR-124 hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidSYNPO 3' UTR sequence
    Inhib. RNA
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                         Customized lentivirus expression plasmids for stable overexpression of SYNPO 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYNPO


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SYNPO

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/8 Interacting proteins for SYNPO (Q8N3V73 ENSP000003021394) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAGI1Q96QZ73, ENSP000003854504I2D: score=3 STRING: ENSP00000385450
    YWHAGP619813, ENSP000003063304I2D: score=3 STRING: ENSP00000306330
    YWHAZP631043, ENSP000003095034I2D: score=2 STRING: ENSP00000309503
    WNK1Q9H4A33, ENSP000003130594I2D: score=1 STRING: ENSP00000313059
    GRB2P629933, ENSP000003390074I2D: score=1 STRING: ENSP00000339007
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0032233positive regulation of actin filament bundle assembly ISS--
    GO:0051492regulation of stress fiber assembly ISS--

    SYNPO for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SYNPO for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SYNPO

    2 Novoseek inferred chemical compound relationships for SYNPO gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    steroid 4.29 19 18336100 (8), 16564554 (2), 11135064 (1)
    creatinine 0 2 18685143 (1), 17596726 (1)

    Search CenterWatch for drugs/clinical trials and news about SYNPO

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SYNPO gene (4 alternative transcripts): 
    NM_001109974.2  NM_001166208.1  NM_001166209.1  NM_007286.5  

    Unigene Cluster for SYNPO:

    Synaptopodin
    Hs.435228  [show with all ESTs]
    Unigene Representative Sequence: NM_007286
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000394243(uc003lsn.3) ENST00000522122(uc021yfu.1) ENST00000518872
    ENST00000307662(uc003lsp.3) ENST00000519664(uc003lso.4)

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SYNPO
    8/36 QIAGEN miScript miRNA Assays for microRNAs that regulate SYNPO (see all 36):
    hsa-miR-194* hsa-miR-650 hsa-miR-759 hsa-miR-570 hsa-miR-1304 hsa-miR-548m hsa-miR-124 hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidSYNPO 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Clone
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SYNPO

    Additional mRNA sequence: 

    AB028952.1 AF499136.1 AF499137.1 AJ278122.1 AK091066.1 AK095279.1 AK127049.1 AK290178.1 
    AL049298.1 AL049959.1 AL831818.1 BC042624.1 BC113927.1 BC114512.1 BC142683.1 BC146665.1 
    BC152538.1 Y11072.1 

    14 DOTS entries:

    DT.212782  DT.95148843  DT.100663805  DT.100814523  DT.100814520  DT.99971048  DT.95148839  DT.120876890 
    DT.120876898  DT.92020312  DT.95124298  DT.99992801  DT.100814521  DT.99949580 

    24/273 AceView cDNA sequences (see all 273):

    AX746763 F21715 F28669 AL119558 AJ573002 BQ023492 BM714498 CA394792 
    BE274201 AW732550 AK127049 BX508994 BX501087 AB028952 F25272 F29853 
    NM_007286 AI056286 BU150071 BI259166 AI956138 AA293680 BF871740 BF338936 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SYNPO expression in normal human tissues (normalized intensities)      SYNPO embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAACAGGGG
    SYNPO Expression
    About this image


    SYNPO expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/18 selected tissues (see all 18) fully expand
     
     Tooth (Integumentary System)    fully expand to see all 4 entries
             visceral organ/oral region/upper jaw   
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Thoracic Rib
             skeleton/pectoral girdle and thoracic body wall/sternum   
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Dorsal Aorta
             heart/valve   
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Chondrocytes Tracheal Cartilage
             Tracheal Cartilage
     
     Nose (Sensory Organs)    fully expand to see all 2 entries
             sensory organ/nose/naris   

    See SYNPO Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SYNPO

    SOURCE GeneReport for Unigene cluster: Hs.435228

    UniProtKB/Swiss-Prot: SYNPO_HUMAN, Q8N3V7
    Tissue specificity: Expressed in cerebral cortex

        SABiosciences Expression via Pathway-Focused PCR Array including SYNPO: 
              Synaptic Plasticity in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYNPO

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for SYNPO gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Synpo1 , 5 synaptopodin1, 5 83.28(n)1
    83.78(a)1
      18 (34.36 cM)5
    1040271  NM_001109975.11  NP_001103445.11 
     605939735 
    chicken
    (Gallus gallus)
    Aves SYNPO6
    synaptopodin
    37(a)
    1 ↔ 1
    13(12415125-12417545)
    lizard
    (Anolis carolinensis)
    Reptilia SYNPO6
    Uncharacterized protein
    37(a)
    1 ↔ 1
    2(138508956-138511334)
    zebrafish
    (Danio rerio)
    Actinopterygii SYNPO6
    synaptopodin
    29(a)
    1 ↔ 1
    Zv9_NA403(44369-57460)


    ENSEMBL Gene Tree for SYNPO (if available)
    TreeFam Gene Tree for SYNPO (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SYNPO gene
    SYNPO22  SYNPO2L2  

    SYNPO for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1296 SNPs in SYNPO are shown (see all 1296)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs119601461,2
    C,F,H--149978644(+) AGGAGG/TCCTGT 1 -- us2k17Minor allele frequency- T:0.28NA WA CSA EA 247
    rs119601081,2
    C,F,A,H--149978662(+) TGTTGC/GAACCC 1 -- us2k124Minor allele frequency- G:0.21NS EA NA WA CSA 2643
    rs755727121,2
    F--149978712(+) TTCCAA/GACAGG 1 -- us2k10--------
    rs1164353961,2
    F--149978728(+) CACCAT/AGTACC 1 -- us2k11Minor allele frequency- A:0.02WA 118
    rs768564911,2
    C,F--149978737(+) CCGGGC/AGAAGC 1 -- us2k11Minor allele frequency- A:0.02EA 120
    rs1504366281,2
    --149978738(+) CGGGCA/GAAGCC 1 -- us2k10--------
    rs1917375261,2
    --149978791(+) GAAACA/GACGAT 1 -- us2k10--------
    rs1827926931,2
    --149978970(+) TTGGCG/TGTAGA 1 -- us2k10--------
    rs1412598441,2
    --149979058(+) GACCCA/GCACTG 1 -- us2k10--------
    rs1449855111,2
    --149979123(+) GCCTAA/GGGAGA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SYNPO (149980642 - 150038792 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for SYNPO:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv5064CNV Insertion18451855
    nsv428129CNV Loss18775914
    nsv5063CNV Loss18451855
    esv33898CNV Loss17666407
    dgv1862e1CNV Complex17122850


    Human Gene Mutation Database (HGMD): SYNPO
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SYNPO
    DNA2.0 Custom Variant and Variant Library Synthesis for SYNPO

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608155    OMIM disorders: --

    20 diseases for SYNPO:    About MalaCards
    pauci-immune glomerulonephritis    crescentic glomerulonephritis    membranous glomerulonephritis    focal segmental glomerulosclerosis
    nephrosclerosis    proteinuria    nephroblastoma    nephrotic syndrome
    glomerulonephritis    lupus nephritis    wilms tumor    nephritis
    ischemia    prostate cancer    hypertension    cerebritis
    prostatitis    alzheimer's disease    endotheliitis    neuronitis

    3 diseases from the University of Copenhagen DISEASES database for SYNPO:
    Proteinuria     Glomerulonephritis     Nephrotic syndrome

    SYNPO for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10 Novoseek inferred disease relationships for SYNPO gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glomerulosclerosis, focal segmental 86.2 7 19666657 (2), 11135064 (1), 16564554 (1), 11793093 (1) (see all 6)
    hiv-associated nephropathy 81.4 1 9890309 (1)
    proteinuria 65.7 9 17596726 (2), 16564554 (1), 11793093 (1), 16628251 (1) (see all 6)
    nephrotic syndrome 62.3 4 11135064 (2), 15693890 (1), 11793093 (1)
    diabetic nephropathies 60.6 1 17596726 (1)
    wilms tumor 53.7 5 14569107 (2), 11158216 (1), 19755763 (1), 14531802 (1)
    sclerosis 46.6 2 11135064 (1), 18336100 (1)
    hypertrophy 7.35 1 19755763 (1)
    tumors 2.14 1 16205945 (1)
    prostate cancer 0 1 11696420 (1)

    Genetic Association Database (GAD): SYNPO
    Human Genome Epidemiology (HuGE) Navigator: SYNPO (1 document)

    Export disorders for SYNPO gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SYNPO gene, integrated from 9 sources (see all 117):
    (articles sorted by number of sources associating them with SYNPO)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Synaptopodin: an actin-associated protein in telencephalic dendrites and renal podocytes. (PubMed id 9314539)1, 2, 3, 9 Mundel P.... Kriz W. (1997)
    2. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)1, 2, 3 Kikuno R....Ohara O. (1999)
    3. Human Variation in Alcohol Response Is Influenced by Variation in Neuronal Signaling Genes. (PubMed id 20201926)1, 4 Joslyn G....White R.L. (2010)
    4. KIBRA modulates directional migration of podocytes. (PubMed id 18596123)1, 2 Duning K.... Pavenstaedt H. (2008)
    5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    6. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. Interaction of two actin-binding proteins, synaptopodin and alpha- actinin-4, with the tight junction protein MAGI-1. (PubMed id 12042308)1, 2 Patrie K.M.... Margolis B. (2002)
    9. Expression of synaptopodin and GLEPP1 as markers of steroid responsiveness in primary focal segmental glomerulosclerosis. (PubMed id 16564554)1, 9 Hirakawa M....Iida M. (2006)
    10. Functional analysis of promoter mutations in the ACTN 4 and SYNPO genes in focal segmental glomerulosclerosis. (PubMed id 19666657)1, 9 Dai S....Chen N. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11346 HGNC: 30672 AceView: SYNPOandMYOZ3 Ensembl:ENSG00000171992 euGenes: HUgn11346
    ECgene: SYNPO H-InvDB: SYNPO

    (According to HUGE)
    About This Section
    HUGE: KIAA1029

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SYNPO Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SYNPO gene:
    Search GeneIP for patents involving SYNPO

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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