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SYNPO Gene

protein-coding   GIFtS: 55
GCID: GC05P149960

Synaptopodin

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
synaptopodin1 2
KIAA10293

External Ids:    HGNC: 306721   Entrez Gene: 113462   Ensembl: ENSG000001719927   OMIM: 6081555   UniProtKB: Q8N3V73   

Export aliases for SYNPO gene to outside databases

Previous GC identifers: GC05P149963 GC05P150009 GC05P145127


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SYNPO Gene:
Synaptopodin is an actin-associated protein that may play a role in actin-based cell shape and motility. The name
synaptopodin derives from the protein's associations with postsynaptic densities and dendritic spines and with
renal podocytes (Mundel et al., 1997 (PubMed 9314539)).(supplied by OMIM, Mar 2008)

GeneCards Summary for SYNPO Gene:
SYNPO (synaptopodin) is a protein-coding gene. Diseases associated with SYNPO include pauci-immune glomerulonephritis, and crescentic glomerulonephritis. GO annotations related to this gene include actin binding. An important paralog of this gene is SYNPO2.

UniProtKB/Swiss-Prot: SYNPO_HUMAN, Q8N3V7
Function: Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic
spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines
of telencephalic neurons, which is involved in synaptic plasticity (By similarity)

Gene Wiki entry for SYNPO Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000005.10  NT_029289.12  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SYNPO gene promoter:
         NF-1   AML1a   p53   MyoD   Olf-1   MEF-2A   Msx-1   aMEF-2   Zic3   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSYNPO promoter sequence
   Search Chromatin IP Primers for SYNPO

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SYNPO


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q33.1   Ensembl cytogenetic band:  5q33.1   HGNC cytogenetic band: 5q33.1

SYNPO Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SYNPO gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P149960:  view genomic region     (about GC identifiers)

Start:
149,980,642 bp from pter      End:
150,038,792 bp from pter
Size:
58,151 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SYNPO_HUMAN, Q8N3V7 (See protein sequence)
Recommended Name: Synaptopodin  
Size: 929 amino acids; 99463 Da
Subunit: Interacts with BAIAP1. Interacts with actin (By similarity). Interacts (via PPxY motifs) with WWC1 (via
WW domains)
Sequence caution: Sequence=BAA82981.2; Type=Erroneous initiation;
Secondary accessions: A5PKZ8 D3DQG8 O15271 Q9UPX1
Alternative splicing: 3 isoforms:  Q8N3V7-1   Q8N3V7-2   Q8N3V7-3   (Contains a phosphoserine at position 871. Contains a phosphoserine at position 826. Contains a phosphoserine at position 894. Contains a phosphoserine at position 854)

Explore the universe of human proteins at neXtProt for SYNPO: NX_Q8N3V7

Explore proteomics data for SYNPO at MOPED

Post-translational modifications: 

  • O-glycosylated (By similarity)1
  • Isoform 2 is phosphorylated on Ser-826, Thr-836, Ser-840 and Ser-8711
  • Glycosylation2 at Asn330
  • Modification sites at PhosphoSitePlus

  • See SYNPO Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001103444.1  NP_001159680.1  NP_001159681.1  NP_009217.3  

    ENSEMBL proteins: 
     ENSP00000377789   ENSP00000428378   ENSP00000302139   ENSP00000429268  

    SYNPO Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Protein for SYNPO
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    Novus Biologicals SYNPO Protein
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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for SYNPO

    SYNPO Antibody Products:

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    LSBio Antibodies in human, mouse, rat for SYNPO

    SYNPO Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for SYNPO
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SYNPO
    Cloud-Clone Corp. CLIAs for SYNPO


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR028753 Synpo

    Graphical View of Domain Structure for InterPro Entry Q8N3V7

    ProtoNet protein and cluster: Q8N3V7

    UniProtKB/Swiss-Prot: SYNPO_HUMAN, Q8N3V7
    Similarity: Belongs to the synaptopodin family


    SYNPO for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SYNPO_HUMAN, Q8N3V7
    Function: Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic
    spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines
    of telencephalic neurons, which is involved in synaptic plasticity (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding ISS--
    GO:0005515protein binding IPI15841212
         
    SYNPO for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Synpo):
     behavior/neurological  nervous system  renal/urinary system 

    SYNPO for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SYNPO
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SYNPO

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SYNPO
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SYNPO

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat SYNPO using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SYNPO (see all 36):
    hsa-miR-194* hsa-miR-650 hsa-miR-759 hsa-miR-570 hsa-miR-1304 hsa-miR-548m hsa-miR-124 hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidSYNPO 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SYNPO
    Predesigned siRNA for gene silencing in human, mouse, rat SYNPO

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SYNPO

    Clone
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    OriGene clones in human, mouse for SYNPO (see all 20)
    OriGene ORF clones in mouse, rat for SYNPO
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): SYNPO (NM_007286)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SYNPO
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYNPO

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    Browse ESI BIO Cell Lines and PureStem Progenitors for SYNPO 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYNPO


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SYNPO_HUMAN, Q8N3V7: Cytoplasm, cytoskeleton (By similarity). Cell junction, tight junction (By similarity).
    Perikaryon (By similarity). Cell projection, dendritic spine (By similarity). Cell junction, synapse,
    postsynaptic cell membrane, postsynaptic density (By similarity). Cell junction, synapse (By similarity).
    Note=Localized at the tight junction of cells. In brain, localized to the postsynaptic densities and in the
    perikarya. Associated with dendritic spines of a subset of synapses (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton4
    nucleus3
    plasma membrane3
    cytosol2
    extracellular2

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001725stress fiber IEA--
    GO:0005737cytoplasm IEA--
    GO:0005923tight junction IEA--
    GO:0014069postsynaptic density IEA--
    GO:0015629actin cytoskeleton ISS--

    SYNPO for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including SYNPO: 
              Synaptic Plasticity in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for SYNPO

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for SYNPO (Q8N3V73 ENSP000003021394) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAGI1Q96QZ73, ENSP000003854504I2D: score=3 STRING: ENSP00000385450
    YWHAGP619813, ENSP000003063304I2D: score=3 STRING: ENSP00000306330
    YWHAZP631043, ENSP000003095034I2D: score=2 STRING: ENSP00000309503
    WNK1Q9H4A33, ENSP000003130594I2D: score=1 STRING: ENSP00000313059
    GRB2P629933, ENSP000003390074I2D: score=1 STRING: ENSP00000339007
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0032233positive regulation of actin filament bundle assembly ISS--
    GO:0051492regulation of stress fiber assembly ISS--

    SYNPO for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SYNPO

    2 Novoseek inferred chemical compound relationships for SYNPO gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    steroid 4.29 19 18336100 (8), 16564554 (2), 11135064 (1)
    creatinine 0 2 18685143 (1), 17596726 (1)



    SYNPO for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SYNPO gene (4 alternative transcripts): 
    NM_001109974.2  NM_001166208.1  NM_001166209.1  NM_007286.5  

    Unigene Cluster for SYNPO:

    Synaptopodin
    Hs.435228  [show with all ESTs]
    Unigene Representative Sequence: NM_007286
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000394243(uc003lsn.3) ENST00000522122(uc021yfu.1) ENST00000518872
    ENST00000307662(uc003lsp.3) ENST00000519664(uc003lso.4)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SYNPO using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SYNPO (see all 36):
    hsa-miR-194* hsa-miR-650 hsa-miR-759 hsa-miR-570 hsa-miR-1304 hsa-miR-548m hsa-miR-124 hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidSYNPO 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SYNPO
    Predesigned siRNA for gene silencing in human, mouse, rat SYNPO
    Clone
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    OriGene clones in human, mouse for SYNPO (see all 20)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): SYNPO (NM_007286)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SYNPO
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYNPO
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for SYNPO
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SYNPO
      QuantiTect SYBR Green Assays in human, mouse, rat SYNPO
      QuantiFast Probe-based Assays in human, mouse, rat SYNPO

    Additional mRNA sequence: 

    AB028952.1 AF499136.1 AF499137.1 AJ278122.1 AK091066.1 AK095279.1 AK127049.1 AK290178.1 
    AL049298.1 AL049959.1 AL831818.1 BC042624.1 BC113927.1 BC114512.1 BC142683.1 BC146665.1 
    BC152538.1 Y11072.1 

    14 DOTS entries:

    DT.212782  DT.95148843  DT.100663805  DT.100814523  DT.100814520  DT.99971048  DT.95148839  DT.120876890 
    DT.120876898  DT.92020312  DT.95124298  DT.99992801  DT.100814521  DT.99949580 

    Selected AceView cDNA sequences (see all 273):

    BF338936 AW732550 F21715 AK127049 AI056286 AB028952 BU150071 AW967275 
    BQ899749 AJ346805 BX508994 AI804447 F26310 AX746763 AA302622 BF871740 
    N62311 AF499137 Y11072 BE907317 F29853 BX501087 AA397825 AJ346453 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SYNPO expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAACAGGGG
    SYNPO Expression
    About this image


    SYNPO expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Kidney (Urinary System)    fully expand to see all 4 entries
             Ureteric Bud Cells Ureteric Bud
             Proximal tubule-like cells
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Chondrocytes Tracheal Cartilage
             Tracheal Cartilage
     
     Epithelial Cells
             Presumptive Podocytes Podocyte Layer
     
     Bone (Muscoskeletal System)
             Rib
     
     Cartilage (Muscoskeletal System)
             Tracheal Cartilage
    SYNPO Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SYNPO Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.435228

    UniProtKB/Swiss-Prot: SYNPO_HUMAN, Q8N3V7
    Tissue specificity: Expressed in cerebral cortex

        Pathway & Disease-focused RT2 Profiler PCR Array including SYNPO: 
              Synaptic Plasticity in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYNPO

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SYNPO gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Synpo1 , 5 synaptopodin1, 5 83.52(n)1
    84.2(a)1
      18 (34.36 cM)5
    1040271  NM_177340.21  NP_796314.21 
     605939735 
    chicken
    (Gallus gallus)
    Aves SYNPO6
    synaptopodin
    39(a)
    1 ↔ 1
    13(12415125-12417545)
    lizard
    (Anolis carolinensis)
    Reptilia SYNPO6
    synaptopodin
    35(a)
    1 ↔ 1
    2(138508956-138511334)
    zebrafish
    (Danio rerio)
    Actinopterygii SYNPO6
    synaptopodin
    29(a)
    1 ↔ 1
    Zv9_NA403(44369-57460) ENSDARG00000086156


    ENSEMBL Gene Tree for SYNPO (if available)
    TreeFam Gene Tree for SYNPO (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SYNPO gene
    SYNPO22  SYNPO2L2  

    SYNPO for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SYNPO (see all 1296)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs119601461,2
    C,F,H--149978644(+) AGGAGG/TCCTGT 1 -- us2k17Minor allele frequency- T:0.28NA WA CSA EA 247
    rs119601081,2
    C,F,A,H--149978662(+) TGTTGC/GAACCC 1 -- us2k124Minor allele frequency- G:0.21NS EA NA WA CSA 2643
    rs755727121,2
    F--149978712(+) TTCCAA/GACAGG 1 -- us2k10--------
    rs1164353961,2
    F--149978728(+) CACCAT/AGTACC 1 -- us2k11Minor allele frequency- A:0.02WA 118
    rs768564911,2
    C,F--149978737(+) CCGGGC/AGAAGC 1 -- us2k11Minor allele frequency- A:0.02EA 120
    rs1504366281,2
    --149978738(+) CGGGCA/GAAGCC 1 -- us2k10--------
    rs1917375261,2
    --149978791(+) GAAACA/GACGAT 1 -- us2k10--------
    rs1827926931,2
    --149978970(+) TTGGCG/TGTAGA 1 -- us2k10--------
    rs1412598441,2
    --149979058(+) GACCCA/GCACTG 1 -- us2k10--------
    rs1449855111,2
    --149979123(+) GCCTAA/GGGAGA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SYNPO (149980642 - 150038792 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for SYNPO:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv5064CNV Insertion18451855
    nsv428129CNV Loss18775914
    nsv5063CNV Loss18451855
    esv33898CNV Loss17666407
    dgv1862e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): SYNPO
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SYNPO
    DNA2.0 Custom Variant and Variant Library Synthesis for SYNPO

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608155    OMIM disorders: --

    Selected diseases for SYNPO (see all 22):    
    About MalaCards
    pauci-immune glomerulonephritis    crescentic glomerulonephritis    membranous glomerulonephritis    nephrosclerosis
    focal segmental glomerulosclerosis    glomerulonephritis    nephrotic syndrome    diabetic nephropathy
    proteinuria    nephroblastoma    wilms tumor    lupus nephritis
    nephritis    ischemia    prostate cancer    hiv-1
    hypertension    prostatitis    cerebritis    endotheliitis

    3 diseases from the University of Copenhagen DISEASES database for SYNPO:
    Proteinuria     Glomerulonephritis     Nephrotic syndrome

    SYNPO for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10 Novoseek inferred disease relationships for SYNPO gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glomerulosclerosis, focal segmental 86.2 7 19666657 (2), 11135064 (1), 16564554 (1), 11793093 (1) (see all 6)
    hiv-associated nephropathy 81.4 1 9890309 (1)
    proteinuria 65.7 9 17596726 (2), 16564554 (1), 11793093 (1), 16628251 (1) (see all 6)
    nephrotic syndrome 62.3 4 11135064 (2), 15693890 (1), 11793093 (1)
    diabetic nephropathies 60.6 1 17596726 (1)
    wilms tumor 53.7 5 14569107 (2), 11158216 (1), 19755763 (1), 14531802 (1)
    sclerosis 46.6 2 11135064 (1), 18336100 (1)
    hypertrophy 7.35 1 19755763 (1)
    tumors 2.14 1 16205945 (1)
    prostate cancer 0 1 11696420 (1)

    Genetic Association Database (GAD): SYNPO
    Human Genome Epidemiology (HuGE) Navigator: SYNPO (1 document)

    Export disorders for SYNPO gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SYNPO gene, integrated from 10 sources (see all 118):
    (articles sorted by number of sources associating them with SYNPO)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Synaptopodin: an actin-associated protein in telencephalic dendrites and renal podocytes. (PubMed id 9314539)1, 2, 3, 9 Mundel P.... Kriz W. (J. Cell Biol. 1997)
    2. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)1, 2, 3 Kikuno R.... Ohara O. (DNA Res. 1999)
    3. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PubMed id 20201926)1, 4 Joslyn G....White R.L. (Alcohol. Clin. Exp. Res. 2010)
    4. KIBRA modulates directional migration of podocytes. (PubMed id 18596123)1, 2 Duning K.... Pavenstaedt H. (J. Am. Soc. Nephrol. 2008)
    5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    6. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (Nat. Biotechnol. 2005)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Interaction of two actin-binding proteins, synaptopodin and alpha- actinin-4, with the tight junction protein MAGI-1. (PubMed id 12042308)1, 2 Patrie K.M.... Margolis B. (J. Biol. Chem. 2002)
    9. Expression of synaptopodin and GLEPP1 as markers of steroid responsiveness in primary focal segmental glomerulosclerosis. (PubMed id 16564554)1, 9 Hirakawa M....Iida M. (Life Sci. 2006)
    10. Functional analysis of promoter mutations in the ACTN4 and SYNPO genes in focal segmental glomerulosclerosis. (PubMed id 19666657)1, 9 Dai S....Chen N. (Nephrol. Dial. Transplant. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11346 HGNC: 30672 AceView: SYNPOandMYOZ3 Ensembl:ENSG00000171992 euGenes: HUgn11346
    ECgene: SYNPO H-InvDB: SYNPO

    (According to HUGE)
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    HUGE: KIAA1029

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SYNPO Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SYNPO gene:
    Search GeneIP for patents involving SYNPO

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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