Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SYNM Gene

protein-coding   GIFtS: 54
GCID: GC15P099645

Synemin, Intermediate Filament Protein

(Previous name: desmuslin)
(Previous symbol: DMN)
  See SYNM-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Synemin, Intermediate Filament Protein1 2     synemin2
DMN1 2 3 5     Desmuslin3
desmuslin1 2     KIAA03533
Synemin Alpha1 2     EC 1.4.99.18
Synemin Beta1 2     EC 2.6.1.168
SYN2 3     

External Ids:    HGNC: 244661   Entrez Gene: 233362   Ensembl: ENSG000001822537   OMIM: 6060875   UniProtKB: O150613   

Export aliases for SYNM gene to outside databases

Previous GC identifers: GC15P097463 GC15P075774


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for SYNM Gene:
The protein encoded by this gene is an intermediate filament (IF) family member. IF proteins are cytoskeletal
proteins that confer resistance to mechanical stress and are encoded by a dispersed multigene family. This
protein has been found to form a linkage between desmin, which is a subunit of the IF network, and the
extracellular matrix, and provides an important structural support in muscle. Two alternatively spliced variants
encoding different isoforms have been described for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for SYNM Gene:
SYNM (synemin, intermediate filament protein) is a protein-coding gene. Diseases associated with SYNM include pleomorphic xanthoastrocytoma, and central neurocytoma. GO annotations related to this gene include vinculin binding and structural constituent of cytoskeleton. An important paralog of this gene is NES.

UniProtKB/Swiss-Prot: SYNEM_HUMAN, O15061
Function: Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell
cytoskeleton. It forms heteropolymeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal
proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteropolymeric
IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions
within striated muscle cells




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NC_018926.2  NT_010194.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the SYNM gene promoter:
         NF-1   Pax-6   NRSF form 2   Nkx5-1   AP-2gamma   HEN1   HFH-1   AP-2beta   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSYNM promoter sequence
   Search Chromatin IP Primers for SYNM

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SYNM


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q26.3   Ensembl cytogenetic band:  15q26.3   HGNC cytogenetic band: 15q26.3

SYNM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SYNM gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P099645:  view genomic region     (about GC identifiers)

Start:
99,638,420 bp from pter      End:
99,675,800 bp from pter
Size:
37,381 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: SYNEM_HUMAN, O15061 (See protein sequence)
Recommended Name: Synemin  
Size: 1565 amino acids; 172768 Da
Subunit: Interacts with GFAP and VIM (By similarity). Isoform 1 interacts with TLN1 and VCL. Isoform 2 interacts
with DES and DTNA. Isoform 1 and isoform 2 interact with DMD and UTRN
Developmental stage: In lens, first detected at 16 weeks when expression is weakly and uniformly distributed.
Subsequently, expression becomes much stronger in the epithelium of the anterior part at 25 weeks and later. In
retina, weakly expressed at 15 weeks in the nerve fiber and ganglion cell layers (NFL and GCL). From 25 weeks
onwards, much stronger expression is observed in the endfeet of Mueller cells, the NFL, and GCL, and much lower
expression is observed in a minor subpopulation of cells in the inner cell layer (INL). At 30 and 36 weeks,
expression remains in the neural retina, and subsequently becomes stronger in the NFL, GCL, and INL and is
decreased in Mueller cells. At 36 weeks, also expressed at the external border of the outer nuclear layer (ONL)
(at protein level)
Sequence caution: Sequence=AAI10067.1; Type=Erroneous initiation; Sequence=BAA20810.2; Type=Erroneous initiation;
Secondary accessions: A7E2Y2 Q2TBJ4 Q5NJJ9 Q8TE61 Q8TE62
Alternative splicing: 3 isoforms:  O15061-1   O15061-2   O15061-3   

Explore the universe of human proteins at neXtProt for SYNM: NX_O15061

Explore proteomics data for SYNM at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for SYNM (O15061)
     STIARES  GGDLSQA 


    See SYNM Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_056101.5  NP_663780.2  

    ENSEMBL proteins: 
     ENSP00000453040   ENSP00000336775   ENSP00000330469  

    SYNM Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for SYNM
    OriGene Custom MassSpec
    OriGene Custom Protein Services for SYNM
    GenScript Custom Purified and Recombinant Proteins Services for SYNM
    Novus Biologicals SYNM Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for SYNM 

    SYNM Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SYNM
    Novus Biologicals SYNM Antibodies
    Abcam antibodies for SYNM
    Browse Antibodies at Cloud-Clone Corp.
    Search ThermoFisher Antibodies for SYNM
    Search LSBio for Antibodies for SYNM

    SYNM Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SYNM
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SYNM
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for SYNM 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    IFF4: Intermediate filaments type IV
    AKAP: A-kinase anchor proteins

    2 InterPro protein domains:
     IPR018039 Intermediate_filament_CS
     IPR001664 IF

    Graphical View of Domain Structure for InterPro Entry O15061

    ProtoNet protein and cluster: O15061

    UniProtKB/Swiss-Prot: SYNEM_HUMAN, O15061
    Similarity: Belongs to the intermediate filament family


    Find genes that share domains with SYNM           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SYNEM_HUMAN, O15061
    Function: Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell
    cytoskeleton. It forms heteropolymeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal
    proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteropolymeric
    IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions
    within striated muscle cells

         Enzyme Numbers (IUBMB): EC 1.4.99.12 EC 2.6.1.162

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity ----
    GO:0005200structural constituent of cytoskeleton IDA11737198
    GO:0005515protein binding IPI11353857
    GO:0008307structural constituent of muscle IDA11737198
    GO:0017166vinculin binding IDA18028034
         
    Find genes that share ontologies with SYNM           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for SYNM:
     Increased cilium length after   Synthetic lethal with Ras 

         1 MGI phenotypic allele for Synm (no phenotypes)

    Find genes that share phenotypes with SYNM           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SYNM
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SYNM

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SYNM
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SYNM

    miRNA
    Products:
        
    miRTarBase miRNAs that target SYNM:
    hsa-mir-331-3p (MIRT043331)

    Block miRNA regulation of human, mouse, rat SYNM using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SYNM (see all 43):
    hsa-miR-607 hsa-miR-106a hsa-miR-1224-3p hsa-miR-1260b hsa-miR-578 hsa-miR-301a hsa-miR-519a hsa-miR-3142
    SwitchGear 3'UTR luciferase reporter plasmidSYNM 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SYNM
    Predesigned siRNA for gene silencing in human, mouse, rat SYNM

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SYNM

    Clone
    Products:
         
    OriGene clones in human, mouse for SYNM (see all 13)
    OriGene ORF clones in mouse, rat for SYNM
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SYNM (NM_015286)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SYNM
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYNM
    Addgene plasmids for SYNM 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SYNM
    Browse ESI BIO Cell Lines and PureStem Progenitors for SYNM 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYNM


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    SYNEM_HUMAN, O15061: Cytoplasm, cytoskeleton. Cell junction, adherens junction. Note=There are at least two
    distinct SYNM subpopulations, one in which SYMN interacts with DES within the Z-lines, and another in which it
    interacts with both DTNA and DES at the costamere
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus3
    cytosol2
    plasma membrane1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005882intermediate filament NAS11353857
    GO:0005912adherens junction IDA16777071
    GO:0016020membrane IEA--
    GO:0043034costamere IDA16777071
    GO:0060053neurofilament cytoskeleton TAS14552890

    Find genes that share ontologies with SYNM           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for SYNM About    
    See pathways by source

    SuperPathContained pathways About
    1Cytoplasmic microtubules
    Cytoskeleton remodeling Neurofilaments0.32

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for SYNM
        Cytoskeleton remodeling Neurofilaments


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SYNM
    Interactions:

        GeneGlobe Interaction Network for SYNM

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for SYNM (O150612, 3 ENSP000003367754) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DTNAQ9Y4J82, 3, ENSP000003820644MINT-18685 MINT-18684 I2D: score=3 STRING: ENSP00000382064
    DESP176613, ENSP000003630714I2D: score=2 STRING: ENSP00000363071
    AMPHENSP000003486024STRING: ENSP00000348602
    BIN1ENSP000003167794STRING: ENSP00000316779
    GRB2ENSP000003390074STRING: ENSP00000339007
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0045104intermediate filament cytoskeleton organization TAS16777071

    Find genes that share ontologies with SYNM           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SYNM (SYNEM)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for SYNM gene (2 alternative transcripts): 
    NM_015286.5  NM_145728.2  

    Unigene Cluster for SYNM:

    Synemin, intermediate filament protein
    Hs.207106  [show with all ESTs]
    Unigene Representative Sequence: BC151243
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000560674 ENST00000561323(uc002buo.3 uc002bup.3 uc002buq.3)
    ENST00000561306 ENST00000558420 ENST00000336292 ENST00000328642
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SYNM using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SYNM (see all 43):
    hsa-miR-607 hsa-miR-106a hsa-miR-1224-3p hsa-miR-1260b hsa-miR-578 hsa-miR-301a hsa-miR-519a hsa-miR-3142
    SwitchGear 3'UTR luciferase reporter plasmidSYNM 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SYNM
    Predesigned siRNA for gene silencing in human, mouse, rat SYNM
    Clone
    Products:
         
    OriGene clones in human, mouse for SYNM (see all 13)
    OriGene ORF clones in mouse, rat for SYNM
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SYNM (NM_015286)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SYNM
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYNM
    Addgene plasmids for SYNM 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for SYNM
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SYNM
      QuantiTect SYBR Green Assays in human, mouse, rat SYNM
      QuantiFast Probe-based Assays in human, mouse, rat SYNM

    Additional mRNA sequence: 

    AB002351.2 AF147375.1 AF359284.1 AJ310521.1 AJ310522.1 AJ697971.1 AK026420.1 AL833262.1 
    BC022358.1 BC063699.1 BC110066.1 BC151243.1 X58232.1 

    8 DOTS entries:

    DT.316127  DT.100023294  DT.95323309  DT.121017121  DT.121017238  DT.92427604  DT.91727686  DT.95268800 

    Selected AceView cDNA sequences (see all 131):

    AL833262 AL600041 AA877815 AA505344 BI859508 CD676714 AA382580 BE672430 
    AI356629 CA434327 AL042379 AA687435 F36850 AI399970 AL045261 CD679203 
    AF147375 F00434 AI684884 AL048963 AA559017 AW003659 AI659701 AL597598 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for SYNM    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b
    SP1:                                    
    SP2:                                    


    ECgene alternative splicing isoforms for SYNM

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    SYNM expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCTTTAAAA
    SYNM Expression
    About this image


    SYNM expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             HyStem+BMP4-induced E15 cells
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             HyStem+BMP4-induced E15 cells
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             HyStem+BMP4-induced E15 cells
     
     Eye (Sensory Organs)
             Retina
     
     Brain (Nervous System)
             Hippocampus
    SYNM Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SYNM Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.207106

    UniProtKB/Swiss-Prot: SYNEM_HUMAN, O15061
    Tissue specificity: Isoform 2 is strongly detected in adult heart, fetal skeletal muscles and fetal heart. Isoform
    1 is weakly detected in fetal heart and also in fetal skeletal muscle. Isoform 1 and isoform 2 are detected in
    adult bladder (at protein level). The mRNA is predominantly expressed in heart and muscle with some expression in
    brain which may be due to tissue-specific isoforms

        Custom PCR Arrays for SYNM
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for SYNM
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SYNM
    QuantiTect SYBR Green Assays in human, mouse, rat SYNM
    QuantiFast Probe-based Assays in human, mouse, rat SYNM
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYNM

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for SYNM gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Synm1 , 5 synemin, intermediate filament protein1, 5 76.88(n)1
    70.26(a)1
      7 (37.12 cM)5
    2333351  NM_201639.21  NP_964001.21 
     677301615 
    chicken
    (Gallus gallus)
    Aves SYNM1 synemin, intermediate filament protein 54.49(n)
    42(a)
      395599  NM_204809.1  NP_990140.1 
    lizard
    (Anolis carolinensis)
    Reptilia SYNM6
    synemin, intermediate filament protein
    26(a)
    1 ↔ 1
    GL343383.1(237135-320605)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia synm1 synemin, intermediate filament protein 48.37(n)
    37.25(a)
      100486590  XM_002939269.2  XP_002939315.2 
    zebrafish
    (Danio rerio)
    Actinopterygii synm1 synemin, intermediate filament protein 47.8(n)
    34.72(a)
      558800  XM_005159156.1  XP_005159213.1 


    ENSEMBL Gene Tree for SYNM (if available)
    TreeFam Gene Tree for SYNM (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for SYNM gene
    NES2  
    2 SIMAP similar genes for SYNM using alignment to 3 protein entries:     SYNEM_HUMAN (see all proteins):
    DES    VIM

    Find genes that share paralogs with SYNM           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for SYNM (see all 961)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1477529311,2
    --75772909(+) GCCAGA/GGGATG 2 -- us2k10--------
    rs767914691,2
    C--75772948(+) AGTCAA/TAGAGC 2 -- us2k10--------
    rs734763321,2
    C,F--75772984(+) CCAGGC/AAACTG 2 -- us2k12Minor allele frequency- A:0.11WA 120
    rs2601001,2
    C,F,A--79369177(-) AAACAG/CCAGAG 2 -- us2k1 tfbs314Minor allele frequency- C:0.50NA EA WA CSA 732
    rs1867657321,2
    --79369222(+) GGGAAC/TGGGAG 2 -- us2k10--------
    rs1487665331,2
    --79369261(+) CAAATC/TCCCCT 2 -- us2k10--------
    rs1424269081,2
    --79369267(+) CCCCTG/TTCCCA 2 -- us2k10--------
    rs1509571011,2
    --79369649(+) CACCCC/TAACCA 2 -- us2k10--------
    rs2005537741,2
    C--79369695(+) CACTT-/ATACTG
            
    AGAAC
    2 -- us2k10--------
    rs1407531181,2
    --79369749(+) GCAAGC/TGTACA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for SYNM (99638420 - 99675800 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SYNM (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv987621CNV Deletion20482838
    esv2750111CNV Deletion23290073
    esv2667911CNV Deletion23128226
    esv4381CNV Deletion18987735
    nsv509583CNV Insertion20534489
    nsv1686CNV Insertion18451855
    nsv512412CNV Loss21212237
    esv22522CNV Loss19812545
    esv22082CNV Loss19812545
    esv9228CNV Loss19470904

    Human Gene Mutation Database (HGMD): SYNM
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SYNM
    DNA2.0 Custom Variant and Variant Library Synthesis for SYNM

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 606087    OMIM disorders: --

    9 diseases for SYNM:    
    About MalaCards
    pleomorphic xanthoastrocytoma    central neurocytoma    sclerosing hemangioma    olfactory neuroblastoma
    pulmonary sclerosing hemangioma    mesenchymal chondrosarcoma    pineocytoma    alexander disease
    inflammatory myofibroblastic tumor


    Find genes that share disorders with SYNM           About GenesLikeMe

    8 Novoseek inferred disease relationships for SYNM gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma neuroendocrine 52.2 1 19859629 (1)
    myopathy 44.4 3 12669240 (1), 11454237 (1)
    medulloblastoma 30.5 3 2109316 (3)
    tumors 23.2 14 2109316 (3), 2173427 (2), 1693875 (1), 12588433 (1) (see all 9)
    carcinoma 17.9 6 18509200 (1), 16938526 (1), 19859629 (1)
    adenocarcinoma 17.8 2 2170973 (1), 19859629 (1)
    liver diseases 0 3 16938526 (3)
    cancer 0 2 18084875 (1)


    Export disorders for SYNM gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for SYNM gene, integrated from 10 sources (see all 88):
    (articles sorted by number of sources associating them with SYNM)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic organization and single-nucleotide polymorphism map of desmuslin, a novel intermediate filament protein on chromosome 15q26.3. (PubMed id 11454237)1, 2, 3, 9 Mizuno Y.... Kunkel L.M. (BMC Genet. 2001)
    2. Human synemin gene generates splice variants encoding two distinct intermediate filament proteins. (PubMed id 11737198)1, 2, 3, 9 Titeux M.... Li Z. (Eur. J. Biochem. 2001)
    3. Synemin expression in developing normal and pathological human retina and lens. (PubMed id 14552890)1, 2, 9 Tawk M.... Moura-Neto V. (Exp. Neurol. 2003)
    4. Human alpha-synemin interacts directly with vinculin and metavinculin. (PubMed id 18028034)1, 2, 9 Sun N.... Robson R.M. (Biochem. J. 2008)
    5. Interactions of intermediate filament protein synemin with dystrophin and utrophin. (PubMed id 16777071)1, 2, 9 Bhosle R.C.... Robson R.M. (Biochem. Biophys. Res. Commun. 2006)
    6. Identification of a repeated domain within mammalian alpha-synemin that interacts directly with talin. (PubMed id 18342854)1, 2, 9 Sun N.... Robson R.M. (Exp. Cell Res. 2008)
    7. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    8. Desmuslin, an intermediate filament protein that interacts with alpha-dystrobrevin and desmin. (PubMed id 11353857)1, 2 Mizuno Y.... Kunkel L.M. (Proc. Natl. Acad. Sci. U.S.A. 2001)
    9. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9205841)1, 2 Nagase T.... Ohara O. (DNA Res. 1997)
    10. Expression of the intermediate filament protein synemin in myofibrillar myopathies and other muscle diseases. (PubMed id 12669240)1, 9 OlivAc M....Ferrer I. (Acta Neuropathol. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 23336 HGNC: 24466 AceView: DMN Ensembl:ENSG00000182253 euGenes: HUgn23336
    ECgene: SYNM H-InvDB: SYNM

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA0353

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SYNM Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SYNM gene:
    Search GeneIP for patents involving SYNM

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SYNM  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for SYNM  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SYNM  
     OriGene qSTAR qPCR primer pairs in human, mouse for SYNM   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for SYNM   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SYNM   OriGene Custom Protein Services for SYNM  

     
     
     Block miRNA regulation of human, mouse, rat SYNM using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SYNM
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SYNM Predesigned siRNA for gene silencing in human, mouse, rat SYNM
     QuantiFast Probe-based Assays in human, mouse, rat SYNM QuantiTect SYBR Green Assays in human, mouse, rat SYNM
     Custom PCR Arrays for SYNM Search Chromatin IP Primers for SYNM
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SYNM  GeneGlobe Interaction Network for SYNM
     Regulatory tfbs in SYNM promoter
     GenScript Custom Purified and Recombinant Proteins Services for SYNM GenScript cDNA clones with any tag delivered in your preferred vector for SYNM
     GenScript Custom Assay Services for SYNM GenScript Custom overexpressing Cell Line Services for SYNM
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for SYNM (SYNEM)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SYNM antibodies
     SYNM proteins
     Antibodies for SYNM
     See all of Abcam's Antibodies, Kits and Proteins for SYNM
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for SYNM
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYNM
     SwitchGear 3'UTR luciferase reporter plasmids for SYNM
     SwitchGear Promoter luciferase reporter plasmids for SYNM
     Search ThermoFisher Antibodies for SYNM
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYNM
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SYNM
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SYNM
     Search LSBio for Antibodies for SYNM
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Addgene plasmids for SYNM
      Search eBioscience for proteins for SYNM
      Search eBioscience for elisas for SYNM
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SYNM gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4