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Aliases for SYNJ2BP Gene

Aliases for SYNJ2BP Gene

  • Synaptojanin 2 Binding Protein 2 3
  • OMP25 3 4 6
  • Mitochondrial Outer Membrane Protein 25 3 4
  • Activin Receptor Interacting Protein 5 2 3
  • ARIP2 3 6
  • Synaptojanin-2-Binding Protein 3

External Ids for SYNJ2BP Gene

Previous GeneCards Identifiers for SYNJ2BP Gene

  • GC14M068343
  • GC14M064635
  • GC14M068828
  • GC14M069908
  • GC14M070833
  • GC14M051001

Summaries for SYNJ2BP Gene

GeneCards Summary for SYNJ2BP Gene

SYNJ2BP (Synaptojanin 2 Binding Protein) is a Protein Coding gene. GO annotations related to this gene include protein C-terminus binding and type II activin receptor binding.

Gene Wiki entry for SYNJ2BP Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYNJ2BP Gene

Genomics for SYNJ2BP Gene

Regulatory Elements for SYNJ2BP Gene

Genomic Location for SYNJ2BP Gene

Start:
70,366,496 bp from pter
End:
70,417,090 bp from pter
Size:
50,595 bases
Orientation:
Minus strand

Genomic View for SYNJ2BP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SYNJ2BP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYNJ2BP Gene

Proteins for SYNJ2BP Gene

  • Protein details for SYNJ2BP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P57105-SYJ2B_HUMAN
    Recommended name:
    Synaptojanin-2-binding protein
    Protein Accession:
    P57105
    Secondary Accessions:
    • Q49SH3
    • Q96IA4

    Protein attributes for SYNJ2BP Gene

    Size:
    145 amino acids
    Molecular mass:
    15928 Da
    Quaternary structure:
    • Binds (via the PDZ domain) to isoform 2A of SYNJ2 (via the unique motif in the C-terminus). Interacts with MAPK12.

    Three dimensional structures from OCA and Proteopedia for SYNJ2BP Gene

neXtProt entry for SYNJ2BP Gene

Proteomics data for SYNJ2BP Gene at MOPED

Post-translational modifications for SYNJ2BP Gene

  • Ubiquitination at Lys64
  • Modification sites at PhosphoSitePlus

Other Protein References for SYNJ2BP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SYNJ2BP Gene

Domains for SYNJ2BP Gene

Protein Domains for SYNJ2BP Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SYNJ2BP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P57105

UniProtKB/Swiss-Prot:

SYJ2B_HUMAN :
  • P57105
Domain:
  • Contains 1 PDZ (DHR) domain.
genes like me logo Genes that share domains with SYNJ2BP: view

No data available for Gene Families for SYNJ2BP Gene

Function for SYNJ2BP Gene

Gene Ontology (GO) - Molecular Function for SYNJ2BP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008022 protein C-terminus binding --
GO:0070699 type II activin receptor binding --
genes like me logo Genes that share ontologies with SYNJ2BP: view

Animal Model Products

CRISPR Products

miRNA for SYNJ2BP Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SYNJ2BP

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SYNJ2BP Gene

Localization for SYNJ2BP Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYNJ2BP Gene

Mitochondrion outer membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SYNJ2BP Gene COMPARTMENTS Subcellular localization image for SYNJ2BP gene
Compartment Confidence
mitochondrion 5
cytosol 3
extracellular 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SYNJ2BP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA 18845145
GO:0005741 mitochondrial outer membrane IEA --
GO:0009986 cell surface --
GO:0016021 integral component of membrane IEA --
GO:0031307 integral component of mitochondrial outer membrane --
genes like me logo Genes that share ontologies with SYNJ2BP: view

Pathways for SYNJ2BP Gene

SuperPathways for SYNJ2BP Gene

No Data Available

Gene Ontology (GO) - Biological Process for SYNJ2BP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002092 positive regulation of receptor internalization --
GO:0032926 negative regulation of activin receptor signaling pathway --
GO:0032927 positive regulation of activin receptor signaling pathway --
GO:0048312 intracellular distribution of mitochondria --
GO:2000010 positive regulation of protein localization to cell surface --
genes like me logo Genes that share ontologies with SYNJ2BP: view

No data available for Pathways by source for SYNJ2BP Gene

Transcripts for SYNJ2BP Gene

mRNA/cDNA for SYNJ2BP Gene

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SYNJ2BP

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SYNJ2BP Gene

No ASD Table

Relevant External Links for SYNJ2BP Gene

GeneLoc Exon Structure for
SYNJ2BP
ECgene alternative splicing isoforms for
SYNJ2BP

Expression for SYNJ2BP Gene

mRNA expression in normal human tissues for SYNJ2BP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SYNJ2BP Gene

SOURCE GeneReport for Unigene cluster for SYNJ2BP Gene Hs.443661

genes like me logo Genes that share expressions with SYNJ2BP: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SYNJ2BP Gene

Orthologs for SYNJ2BP Gene

This gene was present in the common ancestor of chordates.

Orthologs for SYNJ2BP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SYNJ2BP 35
  • 99.54 (n)
  • 99.31 (a)
SYNJ2BP 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SYNJ2BP 35
  • 93.79 (n)
  • 95.86 (a)
SYNJ2BP 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SYNJ2BP 35
  • 93.1 (n)
  • 93.1 (a)
SYNJ2BP 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Synj2bp 35
  • 89.43 (n)
  • 91.03 (a)
Synj2bp 16
Synj2bp 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SYNJ2BP 36
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Synj2bp 35
  • 88.28 (n)
  • 88.97 (a)
chicken
(Gallus gallus)
Aves SYNJ2BP 35
  • 69.83 (n)
  • 67.88 (a)
SYNJ2BP 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SYNJ2BP 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia synj2bp 35
  • 62.8 (n)
  • 58.7 (a)
zebrafish
(Danio rerio)
Actinopterygii synj2bp 35
  • 56.34 (n)
  • 54.93 (a)
synj2bp 36
  • 49 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSENDO-3 36
  • 38 (a)
OneToOne
Species with no ortholog for SYNJ2BP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SYNJ2BP Gene

ENSEMBL:
Gene Tree for SYNJ2BP (if available)
TreeFam:
Gene Tree for SYNJ2BP (if available)

Paralogs for SYNJ2BP Gene

Selected SIMAP similar genes for SYNJ2BP Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SYNJ2BP: view

No data available for Paralogs for SYNJ2BP Gene

Variants for SYNJ2BP Gene

Sequence variations from dbSNP and Humsavar for SYNJ2BP Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
VAR_051394 -

Structural Variations from Database of Genomic Variants (DGV) for SYNJ2BP Gene

Variant ID Type Subtype PubMed ID
nsv902075 CNV Gain 21882294
esv1345963 CNV Insertion 17803354
esv989380 CNV Insertion 20482838
esv1691671 CNV Insertion 17803354

Relevant External Links for SYNJ2BP Gene

HapMap Linkage Disequilibrium report
SYNJ2BP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SYNJ2BP Gene

Disorders for SYNJ2BP Gene

Relevant External Links for SYNJ2BP

Genetic Association Database (GAD)
SYNJ2BP
Human Genome Epidemiology (HuGE) Navigator
SYNJ2BP
genes like me logo Genes that share disorders with SYNJ2BP: view

No data available for UniProtKB/Swiss-Prot for SYNJ2BP Gene

Publications for SYNJ2BP Gene

  1. Identification and characterization of human ARIP2 and its relation to breast cancer. (PMID: 19349195) Li Z.D. … Li Y.X. (Cytokine 2009) 3 23
  2. Regulation of endocytosis of activin type II receptors by a novel PDZ protein through Ral/Ral-binding protein 1-dependent pathway. (PMID: 11882656) Matsuzaki T. … Sugino H. (J. Biol. Chem. 2002) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for SYNJ2BP Gene

Sources for SYNJ2BP Gene

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