Aliases for SYNJ2 Gene
External Ids for SYNJ2 Gene
Previous GeneCards Identifiers for SYNJ2 Gene
The gene is a member of the inositol-polyphosphate 5-phosphatase family. The encoded protein interacts with the ras-related C3 botulinum toxin substrate 1, which causes translocation of the encoded protein to the plasma membrane where it inhibits clathrin-mediated endocytosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
GeneCards Summary for SYNJ2 Gene
SYNJ2 (Synaptojanin 2) is a Protein Coding gene. Among its related pathways are Inositol phosphate metabolism (KEGG) and Vesicle-mediated transport. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is SYNJ1.
UniProtKB/Swiss-Prot for SYNJ2 Gene
Inositol 5-phosphatase which may be involved in distinct membrane trafficking and signal transduction pathways. May mediate the inhibitory effect of Rac1 on endocytosis.