Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SYNGR4 Gene

Aliases for SYNGR4 Gene

  • Synaptogyrin 4 2 3 5
  • Testis Tissue Sperm-Binding Protein Li 72n 3
  • Synaptogyrin-4 3

External Ids for SYNGR4 Gene

Previous GeneCards Identifiers for SYNGR4 Gene

  • GC19P049513
  • GC19P049235
  • GC19P053543
  • GC19P053559
  • GC19P048867
  • GC19P045248

Summaries for SYNGR4 Gene

Entrez Gene Summary for SYNGR4 Gene

  • This gene encodes an integral membrane protein. The gene belongs to the synaptogyrin gene family. Like other members of the family the protein contains four transmembrane regions. The exact function of this protein is unclear. [provided by RefSeq, Jul 2008]

GeneCards Summary for SYNGR4 Gene

SYNGR4 (Synaptogyrin 4) is a Protein Coding gene. An important paralog of this gene is SYNGR3.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYNGR4 Gene

Genomics for SYNGR4 Gene

Regulatory Elements for SYNGR4 Gene

Enhancers for SYNGR4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G048328 1.7 FANTOM5 ENCODE dbSUPER 12.7 -32.6 -32616 5.8 CREB3L1 AGO1 FEZF1 YBX1 YY1 ZNF143 ZNF548 ZNF263 SP3 NFYC TMEM143 BICRA GRWD1 CA11 C19orf68 SYNGR4 NOP53-AS1 EMP3 RASIP1 SLC8A2
GH19G048253 1.8 FANTOM5 ENCODE dbSUPER 11.2 -106.8 -106830 7.1 MLX CREB3L1 DMAP1 YY1 SLC30A9 ZNF143 SP3 TBX21 MEF2D ZNF610 CARD8-AS1 ENSG00000268746 PLA2G4C EMP3 SNORD23 CARD8 RPL18 SYNGR4 TMEM143 KDELR1
GH19G048145 0.4 FANTOM5 43.7 -218.5 -218486 0.2 RFX1 SPACA4 SYNGR4 PLA2G4C ENSG00000269321 ENSG00000269534
GH19G048290 1.3 Ensembl ENCODE 11.7 -73.2 -73221 1.9 HDGF CREB3L1 ARNT AGO1 ARID4B SIN3A FEZF1 ZNF2 ZNF143 FOS CCDC114 SYNGR4 TMEM143 GC19P048288 EMP3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SYNGR4 on UCSC Golden Path with GeneCards custom track

Promoters for SYNGR4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000110693 -481 1601 HDGF PKNOX1 CREB3L1 ARNT WRNIP1 ARID4B SIN3A YY1 ZNF766 ZNF143

Genomic Location for SYNGR4 Gene

48,364,281 bp from pter
48,376,377 bp from pter
12,097 bases
Plus strand

Genomic View for SYNGR4 Gene

Genes around SYNGR4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SYNGR4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SYNGR4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYNGR4 Gene

Proteins for SYNGR4 Gene

  • Protein details for SYNGR4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q3KP58

    Protein attributes for SYNGR4 Gene

    234 amino acids
    Molecular mass:
    25820 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SYNGR4 Gene

Post-translational modifications for SYNGR4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SYNGR4 Gene

No data available for DME Specific Peptides for SYNGR4 Gene

Domains & Families for SYNGR4 Gene

Protein Domains for SYNGR4 Gene


Suggested Antigen Peptide Sequences for SYNGR4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the synaptogyrin family.
  • Belongs to the synaptogyrin family.
genes like me logo Genes that share domains with SYNGR4: view

No data available for Gene Families for SYNGR4 Gene

Function for SYNGR4 Gene

genes like me logo Genes that share phenotypes with SYNGR4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SYNGR4 Gene

Localization for SYNGR4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYNGR4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SYNGR4 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for SYNGR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0030672 synaptic vesicle membrane IBA --
GO:0031594 neuromuscular junction IBA --
genes like me logo Genes that share ontologies with SYNGR4: view

Pathways & Interactions for SYNGR4 Gene

SuperPathways for SYNGR4 Gene

No Data Available

Interacting Proteins for SYNGR4 Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
Selected Interacting proteins: ENSP00000344041 for SYNGR4 Gene via STRING

Gene Ontology (GO) - Biological Process for SYNGR4 Gene


No data available for Pathways by source and SIGNOR curated interactions for SYNGR4 Gene

Drugs & Compounds for SYNGR4 Gene

No Compound Related Data Available

Transcripts for SYNGR4 Gene

Unigene Clusters for SYNGR4 Gene

Synaptogyrin 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SYNGR4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b
SP2: - -
SP3: - - -
SP4: -
SP5: - - - -

Relevant External Links for SYNGR4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SYNGR4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SYNGR4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SYNGR4 Gene

This gene is overexpressed in Testis (x41.5).

Protein differential expression in normal tissues from HIPED for SYNGR4 Gene

This gene is overexpressed in Ovary (36.0) and Testis (33.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SYNGR4 Gene

Protein tissue co-expression partners for SYNGR4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SYNGR4 Gene:


SOURCE GeneReport for Unigene cluster for SYNGR4 Gene:

genes like me logo Genes that share expression patterns with SYNGR4: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SYNGR4 Gene

Orthologs for SYNGR4 Gene

This gene was present in the common ancestor of animals.

Orthologs for SYNGR4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SYNGR4 34 35
  • 98.17 (n)
(Bos Taurus)
Mammalia SYNGR4 34 35
  • 83.33 (n)
(Rattus norvegicus)
Mammalia Syngr4 34
  • 80.2 (n)
(Mus musculus)
Mammalia Syngr4 34 16 35
  • 79.97 (n)
(Canis familiaris)
Mammalia SYNGR4 34 35
  • 77.88 (n)
(Monodelphis domestica)
Mammalia SYNGR4 35
  • 62 (a)
(Anolis carolinensis)
Reptilia SYNGR4 35
  • 46 (a)
fruit fly
(Drosophila melanogaster)
Insecta synaptogyrin 35
  • 19 (a)
(Caenorhabditis elegans)
Secernentea sng-1 35
  • 19 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 25 (a)
Species where no ortholog for SYNGR4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for SYNGR4 Gene

Gene Tree for SYNGR4 (if available)
Gene Tree for SYNGR4 (if available)

Paralogs for SYNGR4 Gene

Paralogs for SYNGR4 Gene

(3) SIMAP similar genes for SYNGR4 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SYNGR4: view

Variants for SYNGR4 Gene

Sequence variations from dbSNP and Humsavar for SYNGR4 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000033332 -- 48,364,869(+) CAGGC(C/T)CTTCA intron-variant, upstream-variant-2KB
rs1000105781 -- 48,373,465(+) AGGAG(A/G)AGCAG intron-variant
rs1000234394 -- 48,370,360(+) CACTT(A/G)TAGTC intron-variant
rs1000619979 -- 48,369,080(+) AGACG(C/T)TCTGG intron-variant, upstream-variant-2KB
rs1000849988 -- 48,367,630(+) GCTTC(C/T)AGGAA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SYNGR4 Gene

Variant ID Type Subtype PubMed ID
dgv1793n106 CNV deletion 24896259
esv2718675 CNV deletion 23290073
esv34181 CNV loss 18971310
esv3644586 CNV loss 21293372
esv3893229 CNV loss 25118596
nsv833854 CNV loss 17160897
nsv9739 CNV gain+loss 18304495

Variation tolerance for SYNGR4 Gene

Residual Variation Intolerance Score: 79.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.12; 61.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SYNGR4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SYNGR4 Gene

Disorders for SYNGR4 Gene

Relevant External Links for SYNGR4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SYNGR4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SYNGR4 Gene

Publications for SYNGR4 Gene

  1. A Novel GLP1 Receptor Interacting Protein ATP6ap2 Regulates Insulin Secretion in Pancreatic Beta Cells. (PMID: 26272612) Dai F.F. … Wheeler M.B. (J. Biol. Chem. 2015) 3 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64
  4. A transcript map of the chromosome 19q-Arm glioma tumor suppressor region. (PMID: 10708517) Smith J.S. … Jenkins R.B. (Genomics 2000) 3 64
  5. Characterization of the human synaptogyrin gene family. (PMID: 9760194) Kedra D. … Dumanski J.P. (Hum. Genet. 1998) 3 64

Products for SYNGR4 Gene

Sources for SYNGR4 Gene

Loading form....