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Aliases for SYNGR3 Gene

Aliases for SYNGR3 Gene

  • Synaptogyrin 3 2 3 5

External Ids for SYNGR3 Gene

Previous GeneCards Identifiers for SYNGR3 Gene

  • GC16P002057
  • GC16P002067
  • GC16P001979
  • GC16P002040
  • GC16P001966
  • GC16P002044
  • GC16P002046
  • GC16P002050
  • GC16P002060
  • GC16P002084
  • GC16P002098
  • GC16P002117

Summaries for SYNGR3 Gene

Entrez Gene Summary for SYNGR3 Gene

  • This gene encodes an integral membrane protein. The exact function of this protein is unclear, but studies of a similar murine protein suggest that it is a synaptic vesicle protein that also interacts with the dopamine transporter. The gene product belongs to the synaptogyrin gene family. [provided by RefSeq, Dec 2010]

GeneCards Summary for SYNGR3 Gene

SYNGR3 (Synaptogyrin 3) is a Protein Coding gene. GO annotations related to this gene include protein N-terminus binding and SH2 domain binding. An important paralog of this gene is SYNGR4.

UniProtKB/Swiss-Prot for SYNGR3 Gene

  • Involved in the positive regulation of dopamine transporter activity. Probably facilitates the physical and functional interactions of the transporter with the dopamine vesicular storage system, allowing a more efficient loading of the vesicles with extracellular dopamine after release (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYNGR3 Gene

Genomics for SYNGR3 Gene

Regulatory Elements for SYNGR3 Gene

Promoters for SYNGR3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SYNGR3 on UCSC Golden Path with GeneCards custom track

Genomic Location for SYNGR3 Gene

Chromosome:
16
Start:
1,989,660 bp from pter
End:
1,994,275 bp from pter
Size:
4,616 bases
Orientation:
Plus strand

Genomic View for SYNGR3 Gene

Genes around SYNGR3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SYNGR3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SYNGR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYNGR3 Gene

Proteins for SYNGR3 Gene

  • Protein details for SYNGR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43761-SNG3_HUMAN
    Recommended name:
    Synaptogyrin-3
    Protein Accession:
    O43761
    Secondary Accessions:
    • B2R9S0

    Protein attributes for SYNGR3 Gene

    Size:
    229 amino acids
    Molecular mass:
    24555 Da
    Quaternary structure:
    • Interacts (via N-terminus) with SLC6A3 (via N-terminus).

neXtProt entry for SYNGR3 Gene

Proteomics data for SYNGR3 Gene at MOPED

Post-translational modifications for SYNGR3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SYNGR3 Gene

No data available for DME Specific Peptides for SYNGR3 Gene

Domains & Families for SYNGR3 Gene

Protein Domains for SYNGR3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SYNGR3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43761

UniProtKB/Swiss-Prot:

SNG3_HUMAN :
  • Contains 1 MARVEL domain.
  • Belongs to the synaptogyrin family.
Domain:
  • Contains 1 MARVEL domain.
Family:
  • Belongs to the synaptogyrin family.
genes like me logo Genes that share domains with SYNGR3: view

No data available for Gene Families for SYNGR3 Gene

Function for SYNGR3 Gene

Molecular function for SYNGR3 Gene

GENATLAS Biochemistry:
synaptogyrin 3,putative vesicle protein,expressed in brain and placenta
UniProtKB/Swiss-Prot Function:
Involved in the positive regulation of dopamine transporter activity. Probably facilitates the physical and functional interactions of the transporter with the dopamine vesicular storage system, allowing a more efficient loading of the vesicles with extracellular dopamine after release (By similarity).
genes like me logo Genes that share phenotypes with SYNGR3: view

Animal Model Products

miRNA for SYNGR3 Gene

miRTarBase miRNAs that target SYNGR3

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SYNGR3 Gene

Localization for SYNGR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYNGR3 Gene

Membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Cell junction, synapse. Note=Found at the neuromuscular synapses. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SYNGR3 Gene COMPARTMENTS Subcellular localization image for SYNGR3 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for SYNGR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008021 synaptic vesicle IEA,ISS --
GO:0016021 integral component of membrane IEA,NAS 9760194
GO:0030054 cell junction IEA --
GO:0030672 synaptic vesicle membrane IBA --
genes like me logo Genes that share ontologies with SYNGR3: view

Pathways & Interactions for SYNGR3 Gene

SuperPathways for SYNGR3 Gene

No Data Available

Interacting Proteins for SYNGR3 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000248121%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000263233%0d%0a
Selected Interacting proteins: ENSP00000248121 O43761-SNG3_HUMAN for SYNGR3 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for SYNGR3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SYNGR3 Gene

Drugs & Compounds for SYNGR3 Gene

No Compound Related Data Available

Transcripts for SYNGR3 Gene

Unigene Clusters for SYNGR3 Gene

Synaptogyrin 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SYNGR3 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c
SP1: - - - - - -
SP2: - - -
SP3: - - - -
SP4: -
SP5: -
SP6:

Relevant External Links for SYNGR3 Gene

GeneLoc Exon Structure for
SYNGR3
ECgene alternative splicing isoforms for
SYNGR3

Expression for SYNGR3 Gene

mRNA expression in normal human tissues for SYNGR3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SYNGR3 Gene

This gene is overexpressed in Brain - Cortex (x6.7), Brain - Hypothalamus (x6.2), Brain - Anterior cingulate cortex (BA24) (x6.1), and Brain - Frontal Cortex (BA9) (x5.9).

Protein differential expression in normal tissues from HIPED for SYNGR3 Gene

This gene is overexpressed in Frontal cortex (48.5) and Brain (10.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for SYNGR3 Gene



SOURCE GeneReport for Unigene cluster for SYNGR3 Gene Hs.435277

mRNA Expression by UniProt/SwissProt for SYNGR3 Gene

O43761-SNG3_HUMAN
Tissue specificity: Expressed in brain and placenta.
genes like me logo Genes that share expression patterns with SYNGR3: view

Protein tissue co-expression partners for SYNGR3 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for SYNGR3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SYNGR3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SYNGR3 36
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SYNGR3 35
  • 90.98 (n)
  • 94.32 (a)
SYNGR3 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SYNGR3 35
  • 90.88 (n)
  • 93.87 (a)
mouse
(Mus musculus)
Mammalia Syngr3 16
Syngr3 35
  • 86.17 (n)
  • 93.89 (a)
Syngr3 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SYNGR3 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SYNGR3 36
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Syngr3 35
  • 85.46 (n)
  • 93.09 (a)
chicken
(Gallus gallus)
Aves SYNGR3 35
  • 71.32 (n)
  • 69.43 (a)
SYNGR3 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SYNGR3 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia syngr3 35
  • 64.9 (n)
  • 61.06 (a)
zebrafish
(Danio rerio)
Actinopterygii syngr3a 36
  • 59 (a)
OneToMany
syngr3b 36
  • 58 (a)
OneToMany
syngr3a 35
  • 63.86 (n)
  • 60.18 (a)
fruit fly
(Drosophila melanogaster)
Insecta synaptogyrin 37
  • 38 (a)
synaptogyrin 36
  • 33 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sng-1 36
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
OneToMany
Species with no ortholog for SYNGR3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SYNGR3 Gene

ENSEMBL:
Gene Tree for SYNGR3 (if available)
TreeFam:
Gene Tree for SYNGR3 (if available)

Paralogs for SYNGR3 Gene

Paralogs for SYNGR3 Gene

(3) SIMAP similar genes for SYNGR3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SYNGR3: view

Variants for SYNGR3 Gene

Sequence variations from dbSNP and Humsavar for SYNGR3 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs3743848 -- 1,993,979(-) ATGCA(A/G)AGGGA utr-variant-3-prime
rs9972634 -- 1,994,636(+) ACAGG(C/T)GCCCG downstream-variant-500B
rs12922682 -- 1,992,138(+) CTGCT(A/C/G)GATGT reference, synonymous-codon
rs28537620 -- 1,993,091(+) CAGAC(C/G)AGGGC utr-variant-3-prime
rs28452667 -- 1,988,580(+) CTAAA(G/T)AAATA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SYNGR3 Gene

Variant ID Type Subtype PubMed ID
esv2422427 CNV Duplication 17116639
dgv2540n71 CNV Loss 21882294
dgv2544n71 CNV Loss 21882294
dgv2545n71 CNV Loss 21882294
nsv905048 CNV Loss 21882294
dgv2546n71 CNV Loss 21882294
dgv2547n71 CNV Loss 21882294
dgv2548n71 CNV Gain 21882294
dgv2549n71 CNV Loss 21882294
dgv2550n71 CNV Loss 21882294
nsv905061 CNV Loss 21882294
dgv2551n71 CNV Loss 21882294
nsv471070 CNV Gain 18288195
nsv905070 CNV Gain+Loss 21882294
dgv2552n71 CNV Gain+Loss 21882294
dgv336n27 CNV Loss 19166990
dgv2553n71 CNV Loss 21882294
nsv521569 CNV Loss 19592680
nsv523037 CNV Loss 19592680
nsv471072 CNV Loss 18288195
dgv2554n71 CNV Loss 21882294
nsv905091 CNV Loss 21882294
dgv2555n71 CNV Gain+Loss 21882294
nsv827501 CNV Loss 20364138
dgv455n67 CNV Gain 20364138

Variation tolerance for SYNGR3 Gene

Gene Damage Index Score: 2.01; 37.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SYNGR3 Gene

HapMap Linkage Disequilibrium report
SYNGR3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SYNGR3 Gene

Disorders for SYNGR3 Gene

Relevant External Links for SYNGR3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SYNGR3

No disorders were found for SYNGR3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SYNGR3 Gene

Publications for SYNGR3 Gene

  1. Characterization of the human synaptogyrin gene family. (PMID: 9760194) Kedra D. … Dumanski J.P. (Hum. Genet. 1998) 2 3 4 23 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. The identification of novel proteins that interact with the GLP-1 receptor and restrain its activity. (PMID: 23864651) Huang X. … Wheeler M.B. (Mol. Endocrinol. 2013) 3
  4. Quantitative proteomic analysis of human substantia nigra in Alzheimer's disease, Huntington's disease and Multiple sclerosis. (PMID: 22926577) Chen S. … Liu F. (Neurochem. Res. 2012) 3
  5. Identification of genes associated with chemosensitivity to SAHA/taxane combination treatment in taxane-resistant breast cancer cells. (PMID: 20224928) Chang H. … Chung H.C. (Breast Cancer Res. Treat. 2011) 3

Products for SYNGR3 Gene

Sources for SYNGR3 Gene

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