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Aliases for SYNGR2 Gene

Aliases for SYNGR2 Gene

  • Synaptogyrin 2 2 3 5
  • Cellugyrin 2 3 4
  • Synaptogyrin-2 3

External Ids for SYNGR2 Gene

Previous GeneCards Identifiers for SYNGR2 Gene

  • GC17P075988
  • GC17P079151
  • GC17P076625
  • GC17P076761
  • GC17P073676
  • GC17P076164
  • GC17P071589

Summaries for SYNGR2 Gene

Entrez Gene Summary for SYNGR2 Gene

  • This gene encodes an integral membrane protein containing four transmembrane regions and a C-terminal cytoplasmic tail that is tyrosine phosphorylated. The exact function of this protein is unclear, but studies of a similar rat protein suggest that it may play a role in regulating membrane traffic in non-neuronal cells. The gene belongs to the synaptogyrin gene family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

GeneCards Summary for SYNGR2 Gene

SYNGR2 (Synaptogyrin 2) is a Protein Coding gene. An important paralog of this gene is SYNGR1.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYNGR2 Gene

Genomics for SYNGR2 Gene

Regulatory Elements for SYNGR2 Gene

Enhancers for SYNGR2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G078120 2 FANTOM5 Ensembl ENCODE dbSUPER 12.7 -40.6 -40602 14.8 CREB3L1 MLX AGO1 ZFP64 YBX1 FEZF1 DMAP1 SLC30A9 ZNF143 ZNF263 TMC6 TMC8 SYNGR2 TK1 AFMID TNRC6C-AS1 ENGASE PGS1 TNRC6C
GH17G078167 1.6 FANTOM5 ENCODE dbSUPER 14.3 +0.6 619 2.5 HDGF PKNOX1 ARNT CREB3L1 AGO1 ARID4B SIN3A DMAP1 ZNF143 ZNF207 SYNGR2 PIR60455 GC17M078168 GC17P078172
GH17G078136 1.6 Ensembl ENCODE dbSUPER 13.6 -28.8 -28820 6.3 HDGF PKNOX1 FOXA2 CREB3L1 AGO1 ZFP64 SIN3A ARID4B DMAP1 ZNF2 SYNGR2 TK1 AFMID TNRC6C-AS1 TMC8 TMC6 C17orf99
GH17G078197 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.9 +30.3 30302 3.4 PKNOX1 ARNT FEZF1 YY1 TCF12 GATA2 ZNF548 PAF1 ZHX2 NCOA1 PGS1 TMEM235 SYNGR2 C17orf99 TNRC6C-AS1 ENSG00000200063 RNU6-625P SOCS3 TMC6 TMC8
GH17G078170 1.8 FANTOM5 Ensembl ENCODE dbSUPER 9.3 +5.5 5508 6.1 HDGF AGO1 WRNIP1 ZNF48 YY1 GLIS2 ZNF143 KLF7 PAF1 SP3 AFMID C17orf99 TNRC6C-AS1 SYNGR2 TK1 TMC6 PGS1 SOCS3 GC17P078174
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SYNGR2 on UCSC Golden Path with GeneCards custom track

Promoters for SYNGR2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000098853 249 1601 HDGF PKNOX1 ARNT CREB3L1 AGO1 ARID4B SIN3A DMAP1 ZNF143 ZNF207

Genomic Location for SYNGR2 Gene

Chromosome:
17
Start:
78,168,551 bp from pter
End:
78,173,527 bp from pter
Size:
4,977 bases
Orientation:
Plus strand

Genomic View for SYNGR2 Gene

Genes around SYNGR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SYNGR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SYNGR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYNGR2 Gene

Proteins for SYNGR2 Gene

  • Protein details for SYNGR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43760-SNG2_HUMAN
    Recommended name:
    Synaptogyrin-2
    Protein Accession:
    O43760
    Secondary Accessions:
    • O43762
    • Q3KQZ2
    • Q658S7

    Protein attributes for SYNGR2 Gene

    Size:
    224 amino acids
    Molecular mass:
    24810 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SYNGR2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SYNGR2 Gene

Post-translational modifications for SYNGR2 Gene

  • Ubiquitination at Lys10
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SYNGR2 Gene

Domains & Families for SYNGR2 Gene

Protein Domains for SYNGR2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SYNGR2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43760

UniProtKB/Swiss-Prot:

SNG2_HUMAN :
  • Belongs to the synaptogyrin family.
Family:
  • Belongs to the synaptogyrin family.
genes like me logo Genes that share domains with SYNGR2: view

No data available for Gene Families for SYNGR2 Gene

Function for SYNGR2 Gene

Molecular function for SYNGR2 Gene

GENATLAS Biochemistry:
synaptogyrin 2,putative vesicle protein,expressed in all tissues except in brain

Gene Ontology (GO) - Molecular Function for SYNGR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SYNGR2: view
genes like me logo Genes that share phenotypes with SYNGR2: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SYNGR2 Gene

Localization for SYNGR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYNGR2 Gene

Membrane; Multi-pass membrane protein. Cytoplasmic vesicle.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SYNGR2 gene
Compartment Confidence
extracellular 5
plasma membrane 3
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for SYNGR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008021 synaptic vesicle IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,NAS 9760194
GO:0030672 synaptic vesicle membrane IBA --
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with SYNGR2: view

Pathways & Interactions for SYNGR2 Gene

SuperPathways for SYNGR2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SYNGR2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SYNGR2 Gene

Drugs & Compounds for SYNGR2 Gene

No Compound Related Data Available

Transcripts for SYNGR2 Gene

Unigene Clusters for SYNGR2 Gene

Synaptogyrin 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SYNGR2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
SP1:
SP2: -

Relevant External Links for SYNGR2 Gene

GeneLoc Exon Structure for
SYNGR2
ECgene alternative splicing isoforms for
SYNGR2

Expression for SYNGR2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SYNGR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SYNGR2 Gene

This gene is overexpressed in Nasal epithelium (30.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SYNGR2 Gene



Protein tissue co-expression partners for SYNGR2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SYNGR2 Gene:

SYNGR2

SOURCE GeneReport for Unigene cluster for SYNGR2 Gene:

Hs.464210

mRNA Expression by UniProt/SwissProt for SYNGR2 Gene:

O43760-SNG2_HUMAN
Tissue specificity: Ubiquitous; low expression in brain.

Evidence on tissue expression from TISSUES for SYNGR2 Gene

  • Lung(4.8)
  • Skin(4.7)
  • Stomach(4.4)
  • Nervous system(3.7)
  • Pancreas(3.5)
  • Intestine(3.4)
  • Muscle(3.1)
  • Heart(2.1)
  • Spleen(2)
genes like me logo Genes that share expression patterns with SYNGR2: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SYNGR2 Gene

Orthologs for SYNGR2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SYNGR2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SYNGR2 34 35
  • 98.06 (n)
cow
(Bos Taurus)
Mammalia SYNGR2 34 35
  • 89.73 (n)
dog
(Canis familiaris)
Mammalia SYNGR2 34 35
  • 88.24 (n)
mouse
(Mus musculus)
Mammalia Syngr2 34 16 35
  • 87.2 (n)
rat
(Rattus norvegicus)
Mammalia Syngr2 34
  • 86.46 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SYNGR2 35
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves SYNGR2 34 35
  • 73.96 (n)
lizard
(Anolis carolinensis)
Reptilia SYNGR2 35
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia syngr2 34
  • 63.17 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100537807 34
  • 60.84 (n)
syngr2b 35 35
  • 49 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta synaptogyrin 36 35
  • 38 (a)
worm
(Caenorhabditis elegans)
Secernentea sng-1 35
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 44 (a)
OneToMany
Species where no ortholog for SYNGR2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SYNGR2 Gene

ENSEMBL:
Gene Tree for SYNGR2 (if available)
TreeFam:
Gene Tree for SYNGR2 (if available)

Paralogs for SYNGR2 Gene

Paralogs for SYNGR2 Gene

(3) SIMAP similar genes for SYNGR2 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for SYNGR2 Gene

genes like me logo Genes that share paralogs with SYNGR2: view

Variants for SYNGR2 Gene

Sequence variations from dbSNP and Humsavar for SYNGR2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000204801 -- 78,168,376(+) TGCGG(C/G)CGGCG upstream-variant-2KB
rs1000633548 -- 78,172,066(+) GCTAA(C/G)GAGCC utr-variant-3-prime
rs1001118230 -- 78,167,137(+) CAGGG(A/T)GTTCT upstream-variant-2KB
rs1001710991 -- 78,168,073(+) CACTG(C/T)CCTTC upstream-variant-2KB
rs1001791632 -- 78,172,441(+) ACCAC(A/C)CTGTG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SYNGR2 Gene

Variant ID Type Subtype PubMed ID
nsv470607 CNV loss 18288195

Variation tolerance for SYNGR2 Gene

Residual Variation Intolerance Score: 67.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.58; 65.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SYNGR2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SYNGR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SYNGR2 Gene

Disorders for SYNGR2 Gene

Relevant External Links for SYNGR2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SYNGR2

No disorders were found for SYNGR2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SYNGR2 Gene

Publications for SYNGR2 Gene

  1. Characterization of the human synaptogyrin gene family. (PMID: 9760194) Kedra D. … Dumanski J.P. (Hum. Genet. 1998) 2 3 4 22 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  4. Synaptogyrin-2 Promotes Replication of a Novel Tick-borne Bunyavirus through Interacting with Viral Nonstructural Protein NSs. (PMID: 27226560) Sun Q. … Xing Z. (J. Biol. Chem. 2016) 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for SYNGR2 Gene

Sources for SYNGR2 Gene

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