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Aliases for SYNGR2 Gene

Aliases for SYNGR2 Gene

  • Synaptogyrin 2 2 3
  • Cellugyrin 2 3 4

External Ids for SYNGR2 Gene

Previous GeneCards Identifiers for SYNGR2 Gene

  • GC17P075988
  • GC17P079151
  • GC17P076625
  • GC17P076761
  • GC17P073676
  • GC17P076164
  • GC17P071589

Summaries for SYNGR2 Gene

Entrez Gene Summary for SYNGR2 Gene

  • This gene encodes an integral membrane protein containing four transmembrane regions and a C-terminal cytoplasmic tail that is tyrosine phosphorylated. The exact function of this protein is unclear, but studies of a similar rat protein suggest that it may play a role in regulating membrane traffic in non-neuronal cells. The gene belongs to the synaptogyrin gene family. [provided by RefSeq, Jul 2008]

GeneCards Summary for SYNGR2 Gene

SYNGR2 (Synaptogyrin 2) is a Protein Coding gene. An important paralog of this gene is SYNGR3.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYNGR2 Gene

Genomics for SYNGR2 Gene

Regulatory Elements for SYNGR2 Gene

Genomic Location for SYNGR2 Gene

Chromosome:
17
Start:
78,168,551 bp from pter
End:
78,173,527 bp from pter
Size:
4,977 bases
Orientation:
Plus strand

Genomic View for SYNGR2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SYNGR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYNGR2 Gene

Proteins for SYNGR2 Gene

  • Protein details for SYNGR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43760-SNG2_HUMAN
    Recommended name:
    Synaptogyrin-2
    Protein Accession:
    O43760
    Secondary Accessions:
    • O43762
    • Q3KQZ2
    • Q658S7

    Protein attributes for SYNGR2 Gene

    Size:
    224 amino acids
    Molecular mass:
    24810 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SYNGR2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SYNGR2 Gene

Proteomics data for SYNGR2 Gene at MOPED

Post-translational modifications for SYNGR2 Gene

  • Ubiquitination at Lys 10
  • Modification sites at PhosphoSitePlus

Other Protein References for SYNGR2 Gene

Antibody Products

No data available for DME Specific Peptides for SYNGR2 Gene

Domains & Families for SYNGR2 Gene

Protein Domains for SYNGR2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SYNGR2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43760

UniProtKB/Swiss-Prot:

SNG2_HUMAN :
  • Contains 1 MARVEL domain.
  • Belongs to the synaptogyrin family.
Domain:
  • Contains 1 MARVEL domain.
Family:
  • Belongs to the synaptogyrin family.
genes like me logo Genes that share domains with SYNGR2: view

No data available for Gene Families for SYNGR2 Gene

Function for SYNGR2 Gene

Molecular function for SYNGR2 Gene

GENATLAS Biochemistry:
synaptogyrin 2,putative vesicle protein,expressed in all tissues except in brain

Gene Ontology (GO) - Molecular Function for SYNGR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SYNGR2: view
genes like me logo Genes that share phenotypes with SYNGR2: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for SYNGR2 Gene

Localization for SYNGR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYNGR2 Gene

Membrane; Multi-pass membrane protein. Cytoplasmic vesicle.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SYNGR2 Gene COMPARTMENTS Subcellular localization image for SYNGR2 gene
Compartment Confidence
extracellular 5
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for SYNGR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008021 synaptic vesicle --
GO:0016020 membrane --
GO:0016021 integral component of membrane NAS 9760194
GO:0030672 synaptic vesicle membrane IBA --
GO:0031594 neuromuscular junction IBA --
genes like me logo Genes that share ontologies with SYNGR2: view

Pathways & Interactions for SYNGR2 Gene

SuperPathways for SYNGR2 Gene

No Data Available

Interacting Proteins for SYNGR2 Gene

Gene Ontology (GO) - Biological Process for SYNGR2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SYNGR2 Gene

Drugs & Compounds for SYNGR2 Gene

No Compound Related Data Available

Transcripts for SYNGR2 Gene

Unigene Clusters for SYNGR2 Gene

Synaptogyrin 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SYNGR2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
SP1:
SP2: -

Relevant External Links for SYNGR2 Gene

GeneLoc Exon Structure for
SYNGR2
ECgene alternative splicing isoforms for
SYNGR2

Expression for SYNGR2 Gene

mRNA expression in normal human tissues for SYNGR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SYNGR2 Gene

This gene is overexpressed in Nasal epithelium (30.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SYNGR2 Gene



SOURCE GeneReport for Unigene cluster for SYNGR2 Gene Hs.464210

mRNA Expression by UniProt/SwissProt for SYNGR2 Gene

O43760-SNG2_HUMAN
Tissue specificity: Ubiquitous; low expression in brain
genes like me logo Genes that share expression patterns with SYNGR2: view

Protein tissue co-expression partners for SYNGR2 Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for SYNGR2 Gene

Orthologs for SYNGR2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SYNGR2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SYNGR2 35
  • 89.73 (n)
  • 87.95 (a)
SYNGR2 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SYNGR2 35
  • 88.24 (n)
  • 89.73 (a)
SYNGR2 36
  • 57 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Syngr2 35
  • 87.2 (n)
  • 88.84 (a)
Syngr2 16
Syngr2 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SYNGR2 35
  • 98.06 (n)
  • 96.3 (a)
SYNGR2 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Syngr2 35
  • 86.46 (n)
  • 87.95 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia SYNGR2 36
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves SYNGR2 35
  • 73.96 (n)
  • 71.14 (a)
SYNGR2 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SYNGR2 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia syngr2 35
  • 63.17 (n)
  • 59.36 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100537807 35
  • 60.84 (n)
  • 51.94 (a)
syngr2b 36
  • 49 (a)
OneToMany
syngr2b 36
  • 49 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta synaptogyrin 37
  • 38 (a)
synaptogyrin 36
  • 38 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sng-1 36
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
OneToMany
Species with no ortholog for SYNGR2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SYNGR2 Gene

ENSEMBL:
Gene Tree for SYNGR2 (if available)
TreeFam:
Gene Tree for SYNGR2 (if available)

Paralogs for SYNGR2 Gene

Paralogs for SYNGR2 Gene

(3) SIMAP similar genes for SYNGR2 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for SYNGR2 Gene

genes like me logo Genes that share paralogs with SYNGR2: view

Variants for SYNGR2 Gene

Sequence variations from dbSNP and Humsavar for SYNGR2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs10358 -- 78,172,138(+) TCAGC(C/T)GCTCA utr-variant-3-prime
rs10588 -- 78,172,368(+) GAGCC(A/G)GACCA utr-variant-3-prime
rs870355 -- 78,170,115(+) TTGTG(A/G)CTTGG intron-variant
rs906555 -- 78,173,035(-) AAGAA(A/G)GGGGC downstream-variant-500B
rs1043222 -- 78,172,427(+) ATGAT(C/T)TGGGG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SYNGR2 Gene

Variant ID Type Subtype PubMed ID
nsv908860 CNV Loss 21882294
dgv3277n71 CNV Loss 21882294
dgv3278n71 CNV Loss 21882294
nsv470607 CNV Loss 18288195
nsv908872 CNV Gain 21882294
dgv3279n71 CNV Loss 21882294

Variation tolerance for SYNGR2 Gene

Residual Variation Intolerance Score: 67.28% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.58; 65.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SYNGR2 Gene

HapMap Linkage Disequilibrium report
SYNGR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SYNGR2 Gene

Disorders for SYNGR2 Gene

Relevant External Links for SYNGR2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SYNGR2
genes like me logo Genes that share disorders with SYNGR2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SYNGR2 Gene

Publications for SYNGR2 Gene

  1. Characterization of the human synaptogyrin gene family. (PMID: 9760194) Kedra D. … Dumanski J.P. (Hum. Genet. 1998) 2 23 67
  2. The C-terminus of GLUT4 targets the transporter to the perinuclear compartment but not to the insulin-responsive vesicles. (PMID: 19076072) Li L.V. … Kandror K.V. (Biochem. J. 2009) 23 67
  3. Cellugyrin induces biogenesis of synaptic-like microvesicles in PC12 cells. (PMID: 15590695) Belfort G.M. … Kandror K.V. (J. Biol. Chem. 2005) 23 67
  4. Cellugyrin is a marker for a distinct population of intracellular Glut4-containing vesicles. (PMID: 10967091) Kupriyanova T.A. … Kandror K.V. (J. Biol. Chem. 2000) 23 67
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67

Products for SYNGR2 Gene

Sources for SYNGR2 Gene

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