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Aliases for SYNGR2 Gene

Aliases for SYNGR2 Gene

  • Synaptogyrin 2 2 3 5
  • Cellugyrin 2 3 4
  • Synaptogyrin-2 3

External Ids for SYNGR2 Gene

Previous GeneCards Identifiers for SYNGR2 Gene

  • GC17P075988
  • GC17P079151
  • GC17P076625
  • GC17P076761
  • GC17P073676
  • GC17P076164
  • GC17P071589

Summaries for SYNGR2 Gene

Entrez Gene Summary for SYNGR2 Gene

  • This gene encodes an integral membrane protein containing four transmembrane regions and a C-terminal cytoplasmic tail that is tyrosine phosphorylated. The exact function of this protein is unclear, but studies of a similar rat protein suggest that it may play a role in regulating membrane traffic in non-neuronal cells. The gene belongs to the synaptogyrin gene family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

GeneCards Summary for SYNGR2 Gene

SYNGR2 (Synaptogyrin 2) is a Protein Coding gene. An important paralog of this gene is SYNGR3.

Additional gene information for SYNGR2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYNGR2 Gene

Genomics for SYNGR2 Gene

Regulatory Elements for SYNGR2 Gene

Enhancers for SYNGR2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H078167 1.6 FANTOM5 ENCODE dbSUPER 14.2 +0.6 619 2.5 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF143 ZNF207 SP3 SP5 SYNGR2 GC17P078172 PIR60455 GC17M078168
GH17H078136 1.6 Ensembl ENCODE dbSUPER 13.5 -28.8 -28820 6.3 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B ZNF766 ZNF143 FOS USP36 SYNGR2 TK1 AFMID TNRC6C-AS1 TMC8 TMC6 C17orf99
GH17H078197 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.9 +30.3 30302 3.4 CTCF PKNOX1 BATF ZIC2 CTBP1 GATA3 POLR2A ZNF548 PAF1 SMARCE1 PGS1 USP36 TMEM235 SYNGR2 C17orf99 TNRC6C-AS1 ENSG00000200063 RNU6-625P SEPT9 SOCS3
GH17H078170 1.8 FANTOM5 Ensembl ENCODE dbSUPER 9.2 +5.5 5508 6.1 HDGF YY1 GLIS2 ZNF143 KLF7 RUNX3 PAF1 SP3 ZHX2 REST AFMID C17orf99 TNRC6C-AS1 SYNGR2 TK1 TMC6 PGS1 SOCS3 GC17P078174
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SYNGR2 on UCSC Golden Path with GeneCards custom track

Promoters for SYNGR2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000098853 249 1601 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF143 ZNF207 SP3 SP5

Genomic Locations for SYNGR2 Gene

Genomic Locations for SYNGR2 Gene
4,977 bases
Plus strand

Genomic View for SYNGR2 Gene

Genes around SYNGR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SYNGR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SYNGR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYNGR2 Gene

Proteins for SYNGR2 Gene

  • Protein details for SYNGR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • O43762
    • Q3KQZ2
    • Q658S7

    Protein attributes for SYNGR2 Gene

    224 amino acids
    Molecular mass:
    24810 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SYNGR2 Gene


neXtProt entry for SYNGR2 Gene

Post-translational modifications for SYNGR2 Gene

  • Ubiquitination at Lys10
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SYNGR2 Gene

Domains & Families for SYNGR2 Gene

Gene Families for SYNGR2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for SYNGR2 Gene


Suggested Antigen Peptide Sequences for SYNGR2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the synaptogyrin family.
  • Belongs to the synaptogyrin family.
genes like me logo Genes that share domains with SYNGR2: view

Function for SYNGR2 Gene

Molecular function for SYNGR2 Gene

GENATLAS Biochemistry:
synaptogyrin 2,putative vesicle protein,expressed in all tissues except in brain

Phenotypes From GWAS Catalog for SYNGR2 Gene

Gene Ontology (GO) - Molecular Function for SYNGR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SYNGR2: view
genes like me logo Genes that share phenotypes with SYNGR2: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SYNGR2 Gene

Localization for SYNGR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYNGR2 Gene

Membrane; Multi-pass membrane protein. Cytoplasmic vesicle.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SYNGR2 gene
Compartment Confidence
extracellular 5
plasma membrane 3
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SYNGR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005811 lipid particle IEA --
GO:0008021 synaptic vesicle IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane NAS,IEA 9760194
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with SYNGR2: view

Pathways & Interactions for SYNGR2 Gene

SuperPathways for SYNGR2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SYNGR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045055 regulated exocytosis ISS --
GO:0048499 synaptic vesicle membrane organization ISS --
genes like me logo Genes that share ontologies with SYNGR2: view

No data available for Pathways by source and SIGNOR curated interactions for SYNGR2 Gene

Drugs & Compounds for SYNGR2 Gene

No Compound Related Data Available

Transcripts for SYNGR2 Gene

Unigene Clusters for SYNGR2 Gene

Synaptogyrin 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SYNGR2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
SP2: -

Relevant External Links for SYNGR2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SYNGR2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SYNGR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SYNGR2 Gene

This gene is overexpressed in Nasal epithelium (30.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SYNGR2 Gene

Protein tissue co-expression partners for SYNGR2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SYNGR2 Gene:


SOURCE GeneReport for Unigene cluster for SYNGR2 Gene:


mRNA Expression by UniProt/SwissProt for SYNGR2 Gene:

Tissue specificity: Ubiquitous; low expression in brain.

Evidence on tissue expression from TISSUES for SYNGR2 Gene

  • Lung(4.8)
  • Skin(4.7)
  • Stomach(4.4)
  • Nervous system(3.7)
  • Pancreas(3.5)
  • Intestine(3.4)
  • Muscle(3.1)
  • Heart(2.1)
  • Spleen(2)
genes like me logo Genes that share expression patterns with SYNGR2: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SYNGR2 Gene

Orthologs for SYNGR2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SYNGR2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SYNGR2 33 34
  • 98.06 (n)
(Bos Taurus)
Mammalia SYNGR2 34 33
  • 89.73 (n)
(Canis familiaris)
Mammalia SYNGR2 33 34
  • 88.24 (n)
(Mus musculus)
Mammalia Syngr2 16 34 33
  • 87.2 (n)
(Rattus norvegicus)
Mammalia Syngr2 33
  • 86.46 (n)
(Ornithorhynchus anatinus)
Mammalia SYNGR2 34
  • 71 (a)
(Gallus gallus)
Aves SYNGR2 34 33
  • 73.96 (n)
(Anolis carolinensis)
Reptilia SYNGR2 34
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia syngr2 33
  • 63.17 (n)
(Danio rerio)
Actinopterygii LOC100537807 33
  • 60.84 (n)
syngr2b 34 34
  • 49 (a)
fruit fly
(Drosophila melanogaster)
Insecta synaptogyrin 34 35
  • 38 (a)
(Caenorhabditis elegans)
Secernentea sng-1 34
  • 26 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 44 (a)
Species where no ortholog for SYNGR2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SYNGR2 Gene

Gene Tree for SYNGR2 (if available)
Gene Tree for SYNGR2 (if available)

Paralogs for SYNGR2 Gene

Paralogs for SYNGR2 Gene

(3) SIMAP similar genes for SYNGR2 Gene using alignment to 6 proteins: Pseudogenes for SYNGR2 Gene

genes like me logo Genes that share paralogs with SYNGR2: view

Variants for SYNGR2 Gene

Sequence variations from dbSNP and Humsavar for SYNGR2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000204801 -- 78,168,376(+) TGCGG(C/G)CGGCG upstream-variant-2KB
rs1000633548 -- 78,172,066(+) GCTAA(C/G)GAGCC utr-variant-3-prime
rs1001118230 -- 78,167,137(+) CAGGG(A/T)GTTCT upstream-variant-2KB
rs1001710991 -- 78,168,073(+) CACTG(C/T)CCTTC upstream-variant-2KB
rs1001791632 -- 78,172,441(+) ACCAC(A/C)CTGTG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SYNGR2 Gene

Variant ID Type Subtype PubMed ID
nsv470607 CNV loss 18288195

Variation tolerance for SYNGR2 Gene

Residual Variation Intolerance Score: 67.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.58; 65.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SYNGR2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SYNGR2 Gene

Disorders for SYNGR2 Gene

Relevant External Links for SYNGR2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SYNGR2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SYNGR2 Gene

Publications for SYNGR2 Gene

  1. Characterization of the human synaptogyrin gene family. (PMID: 9760194) Kedra D … Dumanski JP (Human genetics 1998) 2 3 4 22 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. Synaptogyrin-2 Promotes Replication of a Novel Tick-borne Bunyavirus through Interacting with Viral Nonstructural Protein NSs. (PMID: 27226560) Sun Q … Xing Z (The Journal of biological chemistry 2016) 3 60

Products for SYNGR2 Gene

Sources for SYNGR2 Gene

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