Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SYNGR1 Gene

protein-coding   GIFtS: 56
GCID: GC22P039745

synaptogyrin 1
 Explore 3 diseases affiliated with
SYNGR1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SYNGR1    

Aliases
for SYNGR1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Synaptogyrin 11 2
Synaptogyrin-11

External Ids:    HGNC: 114981   Entrez Gene: 91452   Ensembl: ENSG000001003217   OMIM: 6039255   UniProtKB: O437593   

Export aliases for SYNGR1 gene to outside databases

Previous GC identifers: GC22P036360 GC22P037989 GC22P037988 GC22P038070 GC22P022711


Summaries
for SYNGR1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SYNGR1:
This gene encodes an integral membrane protein associated with presynaptic vesicles in neuronal cells. The exact
function of this protein is unclear, but studies of a similar murine protein suggest that it functions in synaptic
plasticity without being required for synaptic transmission. The gene product belongs to the synaptogyrin gene family.
Three alternatively spliced variants encoding three different isoforms have been identified. (provided by RefSeq, Jul
2008)

UniProtKB/Swiss-Prot: SNG1_HUMAN, O43759
Function: Involved in the regulation of short-term and long-term synaptic plasticity (By similarity)

Gene Wiki entry for SYNGR1


Genomic Views
for SYNGR1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.1  NT_011520.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SYNGR1 gene promoter:
         PPAR-gamma1   Pax-2   Pax-2a   PPAR-gamma2   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SYNGR1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SYNGR1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SYNGR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.1   Ensembl cytogenetic band:  22q13.1   HGNC cytogenetic band: 22q13

SYNGR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SYNGR1 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P039745:  view genomic region     (about GC identifiers)

Start:
 39,745,930 bp from pter      End:
 39,781,593 bp from pter
Size:
 35,664 bases      Orientation:
 plus strand

Proteins
for SYNGR1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SNG1_HUMAN, O43759 (See protein sequence)
Recommended Name: Synaptogyrin-1  
Size: 233 amino acids; 25456 Da
Subcellular location: Membrane; Multi-pass membrane protein. Melanosome. Cell junction, synapse. Note=Identified by
mass spectrometry in melanosome fractions from stage I to stage IV
Secondary accessions: A6NP69 A8K0E2 O43757 O43758 Q53Y02 Q96J56 Q9UGZ4
Alternative splicing: 3 isoforms:  O43759-1   O43759-2   O43759-3   

Explore the universe of human proteins at neXtProt for SYNGR1: NX_O43759

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O43759

    • SYNGR1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_004702.2  NP_663783.1  NP_663791.1  

    ENSEMBL proteins: 
     ENSP00000318845   ENSP00000216155   ENSP00000412442   ENSP00000385447   ENSP00000332287  
     ENSP00000370946  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: SYNGR1
    OriGene Protein Over-expression Lysate: SYNGR1
    OriGene Custom Protein Services for SYNGR1 
    GenScript Custom Purified and Recombinant Proteins Services for SYNGR1
    Novus Biologicals SYNGR1 Proteins
    Novus Biologicals SYNGR1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SYNGR1

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral to plasma membrane ----
    GO:0008021synaptic vesicle ----
    GO:0016021integral to membrane NAS9760194
    GO:0030054cell junction IEA--
    GO:0030672synaptic vesicle membrane IEA--


    SYNGR1 for ontologies           About GeneDecksing



    SYNGR1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies: SYNGR1
    OriGene Custom Antibody Services for SYNGR1 
    GenScript Custom Superior Antibodies Services for SYNGR1
    Novus Biologicals SYNGR1 Antibodies
    Search for Antibodies for SYNGR1 at Abcam  
    Uscn Antibodies for SYNGR1
    ThermoFisher Antibodies for SYNGR1

    Assay Products for SYNGR1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SYNGR1
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for SYNGR1

    Protein Domains /
    Families
    for SYNGR1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SYNGR1 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR016579 Synaptogyrin
     IPR021128 MARVEL-like_dom
     IPR008253 Marvel

    Graphical View of Domain Structure for InterPro Entry O43759

    ProtoNet protein and cluster: O43759

    1 Blocks protein family: IPB008253 Marvel

    UniProtKB/Swiss-Prot: SNG1_HUMAN, O43759
    Similarity: Belongs to the synaptogyrin family
    Similarity: Contains 1 MARVEL domain


    Function
    for SYNGR1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SNG1_HUMAN, O43759
    Function: Involved in the regulation of short-term and long-term synaptic plasticity (By similarity)

         Genatlas biochemistry entry for SYNGR1:
    synaptogyrin,putative vesicle protein,expressed in neurons of the central nervous system,with three alternatively
    spliced isoforms,SYNGR1a,SYNGR1b,SYNGR1c

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 3): SYNGR1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SYNGR1
    8/44 QIAGEN miScript miRNA Assays for microRNAs that regulate SYNGR1 (see all 44):
    hsa-miR-194* hsa-miR-3194-5p hsa-miR-486-3p hsa-miR-218 hsa-miR-654-5p hsa-miR-1243 hsa-miR-556-3p hsa-miR-30b*
    SwitchGear 3'UTR luciferase reporter plasmid: SYNGR1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SYNGR1 (see all 7)
    OriGene shRNA RFP: SYNGR1
    OriGene siRNA: SYNGR1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SYNGR1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SYNGR1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SYNGR1 (see all 6)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SYNGR1 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): SYNGR1 (NM_004711)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SYNGR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYNGR1 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for SYNGR1
    Search LifeMap BioReagents cell lines for SYNGR1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYNGR1

    Animal Models:
         Mouse knock-out Syngr1tm1Sud for SYNGR1
         2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Syngr1):
     nervous system  no phenotypic analysis 

    SYNGR1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SYNGR1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SYNGR1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    5 Interacting proteins for SYNGR1 (O437593 ENSP000003322874) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CREB3O438893I2D: score=1 
    GRIN1Q055863I2D: score=1 
    GRIN2BQ132243I2D: score=1 
    YWHABP319463I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006605protein targeting IEA--
    GO:0048169regulation of long-term neuronal synaptic plasticity ISS--
    GO:0048172regulation of short-term neuronal synaptic plasticity ISS--


    SYNGR1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SYNGR1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SYNGR1
    Search CenterWatch for drugs/clinical trials and news about SYNGR1 / SNG1 

    Transcripts
    for SYNGR1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SYNGR1 gene (3 alternative transcripts): 
    NM_004711.4  NM_145731.3  NM_145738.2  

    Unigene Cluster for SYNGR1:

    Synaptogyrin 1
    Hs.216226  [show with all ESTs]
    Unigene Representative Sequence: NM_004711
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000318801(uc003axo.4) ENST00000216155 ENST00000415332 ENST00000406293
    ENST00000328933(uc003axq.4) ENST00000489206 ENST00000381535(uc003axs.4)


    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 3): SYNGR1
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SYNGR1
    8/44 QIAGEN miScript miRNA Assays for microRNAs that regulate SYNGR1 (see all 44):
    hsa-miR-194* hsa-miR-3194-5p hsa-miR-486-3p hsa-miR-218 hsa-miR-654-5p hsa-miR-1243 hsa-miR-556-3p hsa-miR-30b*
    SwitchGear 3'UTR luciferase reporter plasmid: SYNGR1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SYNGR1 (see all 7)
    OriGene shRNA RFP: SYNGR1
    OriGene siRNA: SYNGR1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SYNGR1
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SYNGR1 (see all 6)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SYNGR1 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): SYNGR1 (NM_004711)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SYNGR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYNGR1 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SYNGR1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SYNGR1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SYNGR1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SYNGR1

    Additional cDNA sequence: 

    AJ002303.1 AJ002304.1 AJ002305.1 AK289507.1 AK295863.1 AK308714.1 BC000731.2 BT007135.1 
    CR456590.1 

    8 DOTS entries:

    DT.217979  DT.95097165  DT.92424981  DT.95200856  DT.75176502  DT.92424980  DT.100781241  DT.100841680 

    24/243 AceView cDNA sequences (see all 243):

    CD671560 Z38383 CD619192 AA324724 BU731216 BG742766 Z42119 BU684728 
    NM_145738 BI752815 BQ898157 CR594457 AA323555 AI086903 BG818916 BU954309 
    BI488579 NM_004711 AA317308 BX501388 BM479463 T31217 BE670337 BE314288 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for SYNGR1 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8
    SP1:                          -     -     -                                       
    SP2:              -           -     -     -                                       
    SP3:              -           -     -     -                 -     -               
    SP4:              -                       -                                       
    SP5:              -           -     -                                             


    ECgene alternative splicing isoforms for SYNGR1

    Expression
    for SYNGR1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SYNGR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SYNGR1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeInner Nuclear LayerMature Horizontal CellsHorizontal, Retina
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ progenitor W8 (Embryonic Progenitor Cell)

    See SYNGR1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SYNGR1

    SOURCE GeneReport for Unigene cluster: Hs.216226
        SABiosciences Custom PCR Arrays for SYNGR1
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SYNGR1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SYNGR1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SYNGR1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SYNGR1
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYNGR1

    Orthologs
    for SYNGR1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for SYNGR1 gene from 6/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SYNGR11 synaptogyrin 1 78.35(n)
    76.62(a)    		   418015  NM_001252278.1  NP_001239207.1 
    lizard
    (Anolis carolinensis)    		 Reptilia SYNGR16
    		 --
    		 78(a)
    		 1 ↔ 1
    		 5(24660061-24699201)
    African clawed frog
    (Xenopus laevis)    		 Amphibia AB072005.12   -- 75.16(n)    AB072005.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii AL921056.12   -- 75.86(n)    AL921056.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta synaptogyrin1 , 3 regulation of calcium ion dependent
    exocytosis3
    CG10808-PA1    		 42(a)3
    56.4(n)1
    44.08(a)1    		   50C63
    365331  NM_137064.21  NP_610908.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea sng-11 Protein SNG-1 43.09(n)
    31.53(a)    		   180995  NM_076838.3  NP_509239.1 


    ENSEMBL Gene Tree for SYNGR1 (if available)
    TreeFam Gene Tree for SYNGR1 (if available) 

    Paralogs
    for SYNGR1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SYNGR1 gene
    SYNGR42  SYNGR32  SYNGR22  
    3 SIMAP similar genes for SYNGR1 using alignment to 5 protein entries:     SNG1_HUMAN (see all proteins):
    SYNGR3    SYNGR2    SYNGR4

    SYNGR1 for paralogs           About GeneDecksing



    Genomic Variants
    for SYNGR1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/772 NCBI SNPs in SYNGR1 are shown (see all 772)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 22 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs110899511,2
    		C,A,H--39743979(+) ttttgG/Tatttt 2 -- us2k10--------
    rs1845495361,2
    		--39744150(+) TTGGTA/GAGGTG 2 -- us2k10--------
    rs1890948141,2
    		--39744163(+) TAACTA/GTTCAA 2 -- us2k10--------
    rs1376951,2
    		F,--39744223(+) cgaacG/Attctt 2 -- us2k12Minor allele frequency- A:0.04NA EA 240
    rs59957141,2
    		--39744316(+) aacaaG/Tgtctt 2 -- us2k10--------
    rs119135991,2
    		C,H,--39744538(+) gctggG/Tactac 2 -- us2k12Minor allele frequency- T:0.25NA WA 4
    rs1430626101,2
    		--39744691(+) CACTGC/TGCCCG 2 -- us2k10--------
    rs1841438161,2
    		--39744714(+) GCTTTC/GTTCTA 2 -- us2k10--------
    rs1482235061,2
    		--39744719(+) CTTCTA/GAAAGT 2 -- us2k10--------
    rs1892645751,2
    		--39744744(+) GTAGAA/CACCTT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for SYNGR1 (39745930 - 39781593 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for SYNGR1
         1 CNV: 9848
    Human Gene Mutation Database (HGMD): SYNGR1

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SYNGR1
    DNA2.0 Custom Variant and Variant Library Synthesis for SYNGR1

    Disorders / Diseases
    for SYNGR1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SYNGR1 for disorders           About GeneDecksing

    OMIM gene information: 603925    OMIM disorders: --

    3 diseases for SYNGR1:    About MalaCards
    neuronitis    bipolar disorder    schizophrenia

    1 disease from the University of Copenhagen DISEASES database for SYNGR1:
    Schizophrenia
    Genetic Association Database (GAD): SYNGR1
    Human Genome Epidemiology (HuGE) Navigator: SYNGR1 (4 documents)

    Export disorders for SYNGR1 gene to outside databases

    Publications
    for SYNGR1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SYNGR1 gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with SYNGR1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the human synaptogyrin gene family. (PubMed id 9760194)1, 2, 3 Kedra D....Dumanski J.P. (1998)
    2. Identification of rare mutations of synaptogyrin 1 gene in patients with schizophrenia. (PubMed id 17049558)1, 2, 9 Cheng M.C. and Chen C.H. (2007)
    3. A nonsense mutation in the synaptogyrin 1 gene in a family with schizophrenia. (PubMed id 14732601)1, 4, 9 Verma R....Brahmachari S.K. (2004)
    4. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)1, 2 Chi A....Hunt D.F. (2006)
    5. SYNGR1 is associated with schizophrenia and bipolar disorder in southern India. (PubMed id 16215643)1, 4 Verma R....Brahmachari S.K. (2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
    8. Essential roles in synaptic plasticity for synaptogyrin I and synaptophysin I. (PubMed id 10595519)1, 3 Janz R....Bolshakov V.Y. (1999)
    9. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I....O'Brien K.P. (1999)
    10. Association study and mutational screening of SYNGR1 as a candidate susceptibility gene for schizophrenia. (PubMed id 19641478)1, 9 Iatropoulos P....Barlati S. (2009)

    External Searches for SYNGR1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SYNGR1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9145 HGNC: 11498 AceView: SYNGR1 Ensembl:ENSG00000100321 euGenes: HUgn9145
    ECgene: SYNGR1 H-InvDB: SYNGR1

    Other Databases showing SYNGR1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SYNGR1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SYNGR1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SYNGR1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SYNGR1 gene:
    Search GeneIP for patents involving SYNGR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for SYNGR1 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for SYNGR1   OriGene shRNA RFP for SYNGR1  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SYNGR1   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SYNGR1  
     OriGene Protein Over-expression Lysate for SYNGR1   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for SYNGR1   OriGene 3'-UTR Clone for SYNGR1  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SYNGR1   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SYNGR1  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for SYNGR1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SYNGR1   OriGene Custom Protein Services for SYNGR1  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SYNGR1
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SYNGR1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SYNGR1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SYNGR1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SYNGR1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SYNGR1
     GenScript Custom Purified and Recombinant Proteins Services for SYNGR1 GenScript cDNA clones with any tag delivered in your preferred vector for SYNGR1
     GenScript Custom Assay Services for SYNGR1 GenScript Custom Superior Antibodies Services for SYNGR1
     GenScript Custom overexpressing Cell Line Services for SYNGR1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in SYNGR1 promoter
     Search Chromatin IP Primers for SYNGR1
     RT2 qPCR Primer Assay in human, mouse, rat SYNGR1
     Search GNC Networks for SYNGR1
     SABiosciences Custom PCR Arrays for SYNGR1
     Search Tocris compounds for SYNGR1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SYNGR1 antibodies
     SYNGR1 proteins
     SYNGR1 lysates
     Search for Antibodies for SYNGR1 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for SYNGR1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     SYNGR1 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for SYNGR1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYNGR1
     SwitchGear 3'UTR luciferase reporter plasmids for SYNGR1
     SwitchGear Promoter luciferase reporter plasmids for SYNGR1
     ThermoFisher Antibodies for SYNGR1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYNGR1
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      SYNGR1 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4