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Aliases for SYNGR1 Gene

Aliases for SYNGR1 Gene

  • Synaptogyrin 1 2 3
  • Synaptogyrin-1 3

External Ids for SYNGR1 Gene

Previous GeneCards Identifiers for SYNGR1 Gene

  • GC22P036360
  • GC22P037989
  • GC22P037988
  • GC22P038070
  • GC22P039745
  • GC22P022711

Summaries for SYNGR1 Gene

Entrez Gene Summary for SYNGR1 Gene

  • This gene encodes an integral membrane protein associated with presynaptic vesicles in neuronal cells. The exact function of this protein is unclear, but studies of a similar murine protein suggest that it functions in synaptic plasticity without being required for synaptic transmission. The gene product belongs to the synaptogyrin gene family. Three alternatively spliced variants encoding three different isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for SYNGR1 Gene

SYNGR1 (Synaptogyrin 1) is a Protein Coding gene. An important paralog of this gene is SYNGR3.

UniProtKB/Swiss-Prot for SYNGR1 Gene

  • Involved in the regulation of short-term and long-term synaptic plasticity.

Gene Wiki entry for SYNGR1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYNGR1 Gene

Genomics for SYNGR1 Gene

Regulatory Elements for SYNGR1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SYNGR1 Gene

39,349,925 bp from pter
39,385,588 bp from pter
35,664 bases
Plus strand

Genomic View for SYNGR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SYNGR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYNGR1 Gene

Proteins for SYNGR1 Gene

  • Protein details for SYNGR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A6NP69
    • A8K0E2
    • O43757
    • O43758
    • Q53Y02
    • Q96J56
    • Q9UGZ4

    Protein attributes for SYNGR1 Gene

    233 amino acids
    Molecular mass:
    25456 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SYNGR1 Gene


neXtProt entry for SYNGR1 Gene

Proteomics data for SYNGR1 Gene at MOPED

Post-translational modifications for SYNGR1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SYNGR1 Gene

Antibody Products

No data available for DME Specific Peptides for SYNGR1 Gene

Domains for SYNGR1 Gene

Protein Domains for SYNGR1 Gene


Suggested Antigen Peptide Sequences for SYNGR1 Gene

Graphical View of Domain Structure for InterPro Entry



  • O43759
  • Contains 1 MARVEL domain.
  • Belongs to the synaptogyrin family.
genes like me logo Genes that share domains with SYNGR1: view

No data available for Gene Families for SYNGR1 Gene

Function for SYNGR1 Gene

Molecular function for SYNGR1 Gene

GENATLAS Biochemistry: synaptogyrin,putative vesicle protein,expressed in neurons of the central nervous system,with three alternatively spliced isoforms,SYNGR1a,SYNGR1b,SYNGR1c
UniProtKB/Swiss-Prot Function: Involved in the regulation of short-term and long-term synaptic plasticity.

Gene Ontology (GO) - Molecular Function for SYNGR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SYNGR1: view

Phenotypes for SYNGR1 Gene

genes like me logo Genes that share phenotypes with SYNGR1: view

Animal Models for SYNGR1 Gene

MGI Knock Outs for SYNGR1:

Animal Model Products

miRNA for SYNGR1 Gene

miRTarBase miRNAs that target SYNGR1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SYNGR1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SYNGR1 Gene

Localization for SYNGR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYNGR1 Gene

Membrane; Multi-pass membrane protein. Melanosome. Cell junction, synapse. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Subcellular locations from

Jensen Localization Image for SYNGR1 Gene COMPARTMENTS Subcellular localization image for SYNGR1 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for SYNGR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008021 synaptic vesicle --
GO:0016020 membrane --
GO:0016021 integral component of membrane NAS 9760194
GO:0030054 cell junction IEA --
GO:0030672 synaptic vesicle membrane IBA --
genes like me logo Genes that share ontologies with SYNGR1: view

Pathways for SYNGR1 Gene

SuperPathways for SYNGR1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SYNGR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006605 protein targeting IEA --
GO:0048169 regulation of long-term neuronal synaptic plasticity ISS --
GO:0048172 regulation of short-term neuronal synaptic plasticity ISS --
genes like me logo Genes that share ontologies with SYNGR1: view

No data available for Pathways by source for SYNGR1 Gene

Transcripts for SYNGR1 Gene

Unigene Clusters for SYNGR1 Gene

Synaptogyrin 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SYNGR1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SYNGR1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SYNGR1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8
SP1: - - -
SP2: - - - -
SP3: - - - - - -
SP4: - -
SP5: - - -
SP6: - - -
SP7: - - -

Relevant External Links for SYNGR1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SYNGR1 Gene

mRNA expression in normal human tissues for SYNGR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SYNGR1 Gene

This gene is overexpressed in Brain - Cerebellum (6.0), Brain - Cortex (5.8), Brain - Cerebellar Hemisphere (5.2), Brain - Frontal Cortex (BA9) (4.7), and Brain - Anterior cingulate cortex (BA24) (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SYNGR1 Gene

SOURCE GeneReport for Unigene cluster for SYNGR1 Gene Hs.216226

genes like me logo Genes that share expressions with SYNGR1: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for SYNGR1 Gene

Orthologs for SYNGR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SYNGR1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SYNGR1 36
  • 87 (a)
(Bos Taurus)
Mammalia SYNGR1 36
  • 85 (a)
(Canis familiaris)
Mammalia SYNGR1 36
  • 84 (a)
(Mus musculus)
Mammalia Syngr1 35
  • 90.56 (n)
  • 94.06 (a)
Syngr1 16
Syngr1 36
  • 94 (a)
(Ornithorhynchus anatinus)
Mammalia SYNGR1 36
  • 62 (a)
(Rattus norvegicus)
Mammalia Syngr1 35
  • 89.95 (n)
  • 93.15 (a)
(Gallus gallus)
Aves SYNGR1 35
  • 78.3 (n)
  • 77.36 (a)
  • 76 (a)
(Anolis carolinensis)
Reptilia SYNGR1 36
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia syngr1 35
  • 69.12 (n)
  • 73.27 (a)
(Danio rerio)
Actinopterygii syngr1a 35
  • 66.83 (n)
  • 66.67 (a)
syngr1a 36
  • 66 (a)
syngr1b 36
  • 52 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011318 35
  • 59.81 (n)
  • 52.78 (a)
fruit fly
(Drosophila melanogaster)
Insecta synaptogyrin 35
  • 57.5 (n)
  • 43.27 (a)
synaptogyrin 36
  • 37 (a)
synaptogyrin 37
  • 42 (a)
(Caenorhabditis elegans)
Secernentea sng-1 35
  • 44.86 (n)
  • 30.86 (a)
sng-1 36
  • 28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 48 (a)
Species with no ortholog for SYNGR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SYNGR1 Gene

Gene Tree for SYNGR1 (if available)
Gene Tree for SYNGR1 (if available)

Paralogs for SYNGR1 Gene

Paralogs for SYNGR1 Gene

Selected SIMAP similar genes for SYNGR1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SYNGR1: view

Variants for SYNGR1 Gene

Sequence variations from dbSNP and Humsavar for SYNGR1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs7423 -- 39,385,424(+) GGGCC(A/C/G/T)CCACT utr-variant-3-prime
rs137694 -- 39,347,972(+) ttttt(-/TTT)gtatt upstream-variant-2KB
rs137695 -- 39,348,218(+) cgaac(A/G)ttctt upstream-variant-2KB
rs137696 -- 39,348,416(+) TTTTT(-/T)GAGAC upstream-variant-2KB
rs137697 -- 39,349,634(+) CAAGC(A/G)TGAAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SYNGR1 Gene

Variant ID Type Subtype PubMed ID
nsv834198 CNV Loss 17160897
nsv834199 CNV Loss 17160897
nsv915098 CNV Loss 21882294
nsv915099 CNV Loss 21882294
nsv817996 CNV Gain 17921354

Relevant External Links for SYNGR1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SYNGR1 Gene

Disorders for SYNGR1 Gene

(1) University of Copenhagen DISEASES for SYNGR1 Gene

Relevant External Links for SYNGR1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with SYNGR1: view

No data available for UniProtKB/Swiss-Prot for SYNGR1 Gene

Publications for SYNGR1 Gene

  1. A nonsense mutation in the synaptogyrin 1 gene in a family with schizophrenia. (PMID: 14732601) Verma R. … Brahmachari S.K. (Biol. Psychiatry 2004) 3 23 48
  2. Identification of rare mutations of synaptogyrin 1 gene in patients with schizophrenia. (PMID: 17049558) Cheng M.C. … Chen C.H. (J. Psychiatr. Res. 2007) 3 4 23
  3. Association study and mutational screening of SYNGR1 as a candidate susceptibility gene for schizophrenia. (PMID: 19641478) Iatropoulos P. … Barlati S. (Psychiatr. Genet. 2009) 3 23 48
  4. Characterization of the human synaptogyrin gene family. (PMID: 9760194) Kedra D. … Dumanski J.P. (Hum. Genet. 1998) 2 3 4
  5. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 3 4

Products for SYNGR1 Gene

Sources for SYNGR1 Gene

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