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Aliases for SYNGR1 Gene

Aliases for SYNGR1 Gene

  • Synaptogyrin 1 2 3 5

External Ids for SYNGR1 Gene

Previous GeneCards Identifiers for SYNGR1 Gene

  • GC22P036360
  • GC22P037989
  • GC22P037988
  • GC22P038070
  • GC22P039745
  • GC22P022711

Summaries for SYNGR1 Gene

Entrez Gene Summary for SYNGR1 Gene

  • This gene encodes an integral membrane protein associated with presynaptic vesicles in neuronal cells. The exact function of this protein is unclear, but studies of a similar murine protein suggest that it functions in synaptic plasticity without being required for synaptic transmission. The gene product belongs to the synaptogyrin gene family. Three alternatively spliced variants encoding three different isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for SYNGR1 Gene

SYNGR1 (Synaptogyrin 1) is a Protein Coding gene. An important paralog of this gene is SYNGR3.

UniProtKB/Swiss-Prot for SYNGR1 Gene

  • Involved in the regulation of short-term and long-term synaptic plasticity.

Gene Wiki entry for SYNGR1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYNGR1 Gene

Genomics for SYNGR1 Gene

Regulatory Elements for SYNGR1 Gene

Enhancers for SYNGR1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SYNGR1 on UCSC Golden Path with GeneCards custom track

Promoters for SYNGR1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SYNGR1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SYNGR1 Gene

Chromosome:
22
Start:
39,349,925 bp from pter
End:
39,385,588 bp from pter
Size:
35,664 bases
Orientation:
Plus strand

Genomic View for SYNGR1 Gene

Genes around SYNGR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SYNGR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SYNGR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYNGR1 Gene

Proteins for SYNGR1 Gene

  • Protein details for SYNGR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43759-SNG1_HUMAN
    Recommended name:
    Synaptogyrin-1
    Protein Accession:
    O43759
    Secondary Accessions:
    • A6NP69
    • A8K0E2
    • O43757
    • O43758
    • Q53Y02
    • Q96J56
    • Q9UGZ4

    Protein attributes for SYNGR1 Gene

    Size:
    233 amino acids
    Molecular mass:
    25456 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SYNGR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SYNGR1 Gene

Proteomics data for SYNGR1 Gene at MOPED

Post-translational modifications for SYNGR1 Gene

  • Ubiquitination at Lys 10
  • Modification sites at PhosphoSitePlus

Other Protein References for SYNGR1 Gene

No data available for DME Specific Peptides for SYNGR1 Gene

Domains & Families for SYNGR1 Gene

Protein Domains for SYNGR1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SYNGR1 Gene

Graphical View of Domain Structure for InterPro Entry

O43759

UniProtKB/Swiss-Prot:

SNG1_HUMAN :
  • Contains 1 MARVEL domain.
  • Belongs to the synaptogyrin family.
Domain:
  • Contains 1 MARVEL domain.
Family:
  • Belongs to the synaptogyrin family.
genes like me logo Genes that share domains with SYNGR1: view

No data available for Gene Families for SYNGR1 Gene

Function for SYNGR1 Gene

Molecular function for SYNGR1 Gene

GENATLAS Biochemistry:
synaptogyrin,putative vesicle protein,expressed in neurons of the central nervous system,with three alternatively spliced isoforms,SYNGR1a,SYNGR1b,SYNGR1c
UniProtKB/Swiss-Prot Function:
Involved in the regulation of short-term and long-term synaptic plasticity.

Phenotypes for SYNGR1 Gene

genes like me logo Genes that share phenotypes with SYNGR1: view

Animal Models for SYNGR1 Gene

MGI Knock Outs for SYNGR1:

Animal Model Products

  • Taconic Biosciences Mouse Models for SYNGR1

miRNA for SYNGR1 Gene

miRTarBase miRNAs that target SYNGR1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SYNGR1 Gene

Localization for SYNGR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYNGR1 Gene

Membrane; Multi-pass membrane protein. Melanosome. Cell junction, synapse. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SYNGR1 Gene COMPARTMENTS Subcellular localization image for SYNGR1 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for SYNGR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008021 synaptic vesicle IEA --
GO:0016021 integral component of membrane NAS 9760194
GO:0030054 cell junction IEA --
GO:0042470 melanosome IEA --
genes like me logo Genes that share ontologies with SYNGR1: view

Pathways & Interactions for SYNGR1 Gene

SuperPathways for SYNGR1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SYNGR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0048172 regulation of short-term neuronal synaptic plasticity ISS --
genes like me logo Genes that share ontologies with SYNGR1: view

No data available for Pathways by source and SIGNOR curated interactions for SYNGR1 Gene

Drugs & Compounds for SYNGR1 Gene

No Compound Related Data Available

Transcripts for SYNGR1 Gene

Unigene Clusters for SYNGR1 Gene

Synaptogyrin 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SYNGR1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8
SP1: - - -
SP2: - - - -
SP3: - - - - - -
SP4: - -
SP5: - - -
SP6: - - -
SP7: - - -

Relevant External Links for SYNGR1 Gene

GeneLoc Exon Structure for
SYNGR1
ECgene alternative splicing isoforms for
SYNGR1

Expression for SYNGR1 Gene

mRNA expression in normal human tissues for SYNGR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SYNGR1 Gene

This gene is overexpressed in Brain - Cerebellum (x6.0), Brain - Cortex (x5.8), Brain - Cerebellar Hemisphere (x5.2), Brain - Frontal Cortex (BA9) (x4.7), and Brain - Anterior cingulate cortex (BA24) (x4.4).

Protein differential expression in normal tissues from HIPED for SYNGR1 Gene

This gene is overexpressed in Nasal epithelium (20.1), Frontal cortex (19.4), and Retina (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SYNGR1 Gene



SOURCE GeneReport for Unigene cluster for SYNGR1 Gene Hs.216226

genes like me logo Genes that share expression patterns with SYNGR1: view

Protein tissue co-expression partners for SYNGR1 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for SYNGR1 Gene

Orthologs for SYNGR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SYNGR1 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Syngr1 35
  • 90.56 (n)
  • 94.06 (a)
Syngr1 16
Syngr1 36
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Syngr1 35
  • 89.95 (n)
  • 93.15 (a)
cow
(Bos Taurus)
Mammalia SYNGR1 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SYNGR1 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SYNGR1 36
  • 62 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SYNGR1 36
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves SYNGR1 35
  • 78.3 (n)
  • 77.36 (a)
SYNGR1 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SYNGR1 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia syngr1 35
  • 69.12 (n)
  • 73.27 (a)
zebrafish
(Danio rerio)
Actinopterygii syngr1a 35
  • 66.83 (n)
  • 66.67 (a)
syngr1a 36
  • 66 (a)
OneToMany
syngr1b 36
  • 52 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta synaptogyrin 37
  • 42 (a)
synaptogyrin 35
  • 57.5 (n)
  • 43.27 (a)
synaptogyrin 36
  • 37 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011318 35
  • 59.81 (n)
  • 52.78 (a)
worm
(Caenorhabditis elegans)
Secernentea sng-1 35
  • 44.86 (n)
  • 30.86 (a)
sng-1 36
  • 28 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 48 (a)
OneToMany
Species with no ortholog for SYNGR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SYNGR1 Gene

ENSEMBL:
Gene Tree for SYNGR1 (if available)
TreeFam:
Gene Tree for SYNGR1 (if available)

Paralogs for SYNGR1 Gene

Paralogs for SYNGR1 Gene

(3) SIMAP similar genes for SYNGR1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SYNGR1: view

Variants for SYNGR1 Gene

Sequence variations from dbSNP and Humsavar for SYNGR1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
VAR_060490 -
rs7423 -- 39,385,424(+) GGGCC(A/C/G/T)CCACT utr-variant-3-prime
rs2267407 -- 39,351,045(+) GGAGG(A/G)GTTCA intron-variant
rs2267408 -- 39,362,825(+) TACCC(C/G)CCGTG intron-variant, upstream-variant-2KB
rs2281112 -- 39,375,837(+) TCCCC(C/G/T)CTGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SYNGR1 Gene

Variant ID Type Subtype PubMed ID
nsv834198 CNV Loss 17160897
nsv834199 CNV Loss 17160897
nsv915098 CNV Loss 21882294
nsv915099 CNV Loss 21882294
nsv817996 CNV Gain 17921354

Variation tolerance for SYNGR1 Gene

Residual Variation Intolerance Score: 28.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.65; 14.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SYNGR1 Gene

Human Gene Mutation Database (HGMD)
SYNGR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SYNGR1 Gene

Disorders for SYNGR1 Gene

Relevant External Links for SYNGR1

Genetic Association Database (GAD)
SYNGR1
Human Genome Epidemiology (HuGE) Navigator
SYNGR1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SYNGR1

No disorders were found for SYNGR1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SYNGR1 Gene

Publications for SYNGR1 Gene

  1. Characterization of the human synaptogyrin gene family. (PMID: 9760194) Kedra D. … Dumanski J.P. (Hum. Genet. 1998) 2 3 4 67
  2. Association study and mutational screening of SYNGR1 as a candidate susceptibility gene for schizophrenia. (PMID: 19641478) Iatropoulos P. … Barlati S. (Psychiatr. Genet. 2009) 3 23
  3. Identification of rare mutations of synaptogyrin 1 gene in patients with schizophrenia. (PMID: 17049558) Cheng M.C. … Chen C.H. (J. Psychiatr. Res. 2007) 3 23
  4. A nonsense mutation in the synaptogyrin 1 gene in a family with schizophrenia. (PMID: 14732601) Verma R. … Brahmachari S.K. (Biol. Psychiatry 2004) 3 23
  5. Essential roles in synaptic plasticity for synaptogyrin I and synaptophysin I. (PMID: 10595519) Janz R. … Bolshakov V.Y. (Neuron 1999) 2 3

Products for SYNGR1 Gene

Sources for SYNGR1 Gene

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