Aliases for SYNE4 Gene
External Ids for SYNE4 Gene
Previous Symbols for SYNE4 Gene
GeneCards Summary for SYNE4 Gene
SYNE4 (Spectrin Repeat Containing, Nuclear Envelope Family Member 4) is a Protein Coding gene. Diseases associated with SYNE4 include deafness, autosomal recessive 76 and autosomal recessive non-syndromic sensorineural deafness type dfnb. GO annotations related to this gene include actin binding.
UniProtKB/Swiss-Prot for SYNE4 Gene
As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning (By similarity). Behaves as a kinesin cargo, providing a functional binding site for kinesin-1 at the nuclear envelope. Hence may contribute to the establishment of secretory epithelial morphology by promoting kinesin-dependent apical migration of the centrosome and Golgi apparatus and basal localization of the nucleus (By similarity).