Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SYNE4 Gene

protein-coding   GIFtS: 38
GCID: GC19M036602

Spectrin Repeat Containing, Nuclear Envelope Family Member...

(Previous name: chromosome 19 open reading frame 46)
(Previous symbol: C19orf46)
  Search for SYNE4
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Spectrin Repeat Containing, Nuclear Envelope Family Member 41 2
C19orf461 2 3
Nuclear Envelope Spectrin Repeat Protein 42 3
Chromosome 19 Open Reading Frame 461
Nesp42
nesprin-42

External Ids:    HGNC: 267031   Entrez Gene: 1631832   Ensembl: ENSG000001813927   UniProtKB: Q8N2053   

Export aliases for SYNE4 gene to outside databases

Previous GC identifer: GC19M036496


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SYNE4 Gene: 
SYNE4 (spectrin repeat containing, nuclear envelope family member 4) is a protein-coding gene. GO annotations related to this gene include actin binding.

UniProtKB/Swiss-Prot: SYNE4_HUMAN, Q8N205
Function: Contributes to the establishment of secretory epithelial morphology by promoting kinesin-dependent
apical migration of the centrosome and Golgi apparatus and basal localization of the nucleus (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  NC_018930.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for SYNE4
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for SYNE4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SYNE4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.12   Ensembl cytogenetic band:  19q13.12   HGNC cytogenetic band: 19q13.12

SYNE4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SYNE4 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M036602:  view genomic region     (about GC identifiers)

Start:
36,494,002 bp from pter      End:
36,499,695 bp from pter
Size:
5,694 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SYNE4_HUMAN, Q8N205 (See protein sequence)
Recommended Name: Nesprin-4  
Size: 404 amino acids; 43512 Da
Subunit: Interacts with KIF5B and KCL1 (By similarity)
Subcellular location: Nucleus outer membrane; Single-pass type IV membrane protein (By similarity). Note=The
nucleus outer membrane location requires the presence of a SUN domain-containing protein (By similarity)
Sequence caution: Sequence=BAC04222.1; Type=Miscellaneous discrepancy; Note=Intron retention;
Secondary accessions: A8MRS0 A8MYE3 Q7Z7L3
Alternative splicing: 2 isoforms:  Q8N205-1   Q8N205-2   

Explore the universe of human proteins at neXtProt for SYNE4: NX_Q8N205

Explore proteomics data for SYNE4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8N205

  • SYNE4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SYNE4 Protein Expression
    REFSEQ proteins: NP_001034965.1  
    ENSEMBL proteins: 
     ENSP00000380572   ENSP00000425550   ENSP00000343152   ENSP00000316130   ENSP00000422716  

    Human Recombinant Protein Products for SYNE4: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for SYNE4
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for SYNE4
    GenScript Custom Purified and Recombinant Proteins Services for SYNE4
    Novus Biologicals SYNE4 Protein
    Novus Biologicals SYNE4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane ----
    GO:0031309integral to nuclear outer membrane ISS--

    SYNE4 for ontologies           About GeneDecksing



    SYNE4 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SYNE4
    GenScript Custom Superior Antibodies Services for SYNE4
    Novus Biologicals SYNE4 Antibodies
    Abcam antibodies for SYNE4
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for SYNE4
    LSBio Antibodies in human, mouse, rat for SYNE4 

    Assay Products for SYNE4: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SYNE4
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SYNE4
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR012315 KASH

    Graphical View of Domain Structure for InterPro Entry Q8N205

    ProtoNet protein and cluster: Q8N205

    UniProtKB/Swiss-Prot: SYNE4_HUMAN, Q8N205
    Domain: The KASH domain, which contains a transmembrane domain, mediates the nuclear envelope targeting and is
    involved in the binding to SUN1 and SUN2 through recognition of their SUN domains (By similarity)
    Similarity: Belongs to the nesprin family
    Similarity: Contains 1 KASH domain


    SYNE4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SYNE4_HUMAN, Q8N205
    Function: Contributes to the establishment of secretory epithelial morphology by promoting kinesin-dependent
    apical migration of the centrosome and Golgi apparatus and basal localization of the nucleus (By similarity)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005515protein binding ----
         
    SYNE4 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Syne4):
     hearing/vestibular/ear  nervous system 

    SYNE4 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SYNE4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SYNE4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SYNE4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SYNE4 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SYNE4
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate SYNE4
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SYNE4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SYNE4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SYNE4
    Sirion Biotech Customized adenovirus for overexpression of SYNE4

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for SYNE4 (see all 8)
    OriGene ORF clones in mouse, rat for SYNE4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for SYNE4
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SYNE4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYNE4
    Sirion Biotech Customized lentivirus for stable overexpression of SYNE4 
                         Customized lentivirus expression plasmids for stable overexpression of SYNE4 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SYNE4
    Search LifeMap BioReagents cell lines for SYNE4
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYNE4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SYNE4

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5/16 Interacting proteins for SYNE4 (Q8N2052, 3 ENSP000003161304) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CSNK2BP678702, 3MINT-8253077 I2D: score=2 
    ENSG00000206406P678702, 3MINT-8253077 I2D: score=2 
    ENSG00000224398P678702, 3MINT-8253077 I2D: score=2 
    ENSG00000224774P678702, 3MINT-8253077 I2D: score=2 
    ENSG00000228875P678702, 3MINT-8253077 I2D: score=2 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0045198establishment of epithelial cell apical/basal polarity ISS--

    SYNE4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SYNE4

    Search CenterWatch for drugs/clinical trials and news about SYNE4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SYNE4 gene (2 alternative transcripts): 
    NM_153233.1  NM_001039876.1  

    Unigene Cluster for SYNE4:

    Spectrin repeat containing, nuclear envelope family member 4
    Hs.436743  [show with all ESTs]
    Unigene Representative Sequence: NM_001039876
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000505054 ENST00000397428 ENST00000503121 ENST00000340477(uc021utd.1 uc002ocs.1)
    ENST00000324444(uc002ocq.1 uc010een.1) ENST00000465425 ENST00000490730(uc002ocr.1)

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SYNE4
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate SYNE4
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SYNE4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SYNE4
    Clone
    Products:
         
    OriGene clones in human, mouse for SYNE4 (see all 8)
    OriGene ORF clones in mouse, rat for SYNE4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for SYNE4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SYNE4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYNE4
    Sirion Biotech Customized lentivirus for stable overexpression of SYNE4 
                         Customized lentivirus expression plasmids for stable overexpression of SYNE4 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for SYNE4
    Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat SYNE4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SYNE4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SYNE4

    Additional mRNA sequence: 

    BC038360.1 BC052573.1 

    5 DOTS entries:

    DT.100752167  DT.86847338  DT.100021380  DT.101981153  DT.121452927 

    24/29 AceView cDNA sequences (see all 29):

    NM_153233 AK093764 AX748293 CR595098 AI244887 AA827649 AW299369 BC038360 
    AW016070 BM976898 AL541773 CB052141 AI052236 BM980299 CB241656 BG740714 
    AI088309 BC052573 BX115848 BF434490 BU538399 AV750009 CB052140 AW615387 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SYNE4    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b
    SP1:                    -     -     -           -                           
    SP2:                                                                        
    SP3:                                                                        
    SP4:              -     -                                                   


    ECgene alternative splicing isoforms for SYNE4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SYNE4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SYNE4 Expression
    About this image


    See SYNE4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SYNE4

    SOURCE GeneReport for Unigene cluster: Hs.436743
        SABiosciences Custom PCR Arrays for SYNE4
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for SYNE4
    Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat SYNE4
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SYNE4
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SYNE4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYNE4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for SYNE4 gene from 1/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Syne41 , 5 expressed sequence AI4289365
    spectrin repeat containing, nuclear envelope family more1
    77.06(n)1
    68.81(a)1
      7 (17.39 cM)5
    2330661  NM_153577.21  NP_705805.11 
     303148075 


    ENSEMBL Gene Tree for SYNE4 (if available)
    TreeFam Gene Tree for SYNE4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/176 SNPs in SYNE4 are shown (see all 176)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs777589491,2
    C,F--36493930(+) CCTAGG/AGTACA 1 -- ds50011Minor allele frequency- A:0.02WA 118
    rs739283791,2
    C--36494195(+) CACCTA/GGTATC 1 -- ut312Minor allele frequency- G:0.04WA 120
    rs739283801,2
    C--36494234(+) ATTACG/ACACAT 1 -- ut311Minor allele frequency- A:0.50WA 2
    rs1466492261,2
    C--36494246(+) AGACTA/GGGGGA 2 P L mis10--------
    rs2008181931,2
    C--36494297(+) GTATTC/TGGGCA 2 Q R mis10--------
    rs1999389881,2
    C--36494327(+) CTGACG/ACGGGC 2 /A /V mis11Minor allele frequency- A:0.00EU 1239
    rs3747021341,2
    C--36494328(+) TGACGC/TGGGCA 2 T A mis10--------
    rs1412025301,2
    C--36494352(+) ACCCAC/TCAGGA 2 M V mis10--------
    rs1449519041,2
    C--36494376(+) GAAGAA/G/TGATAA 3 I L F mis10--------
    rs2021075341,2
    C--36494424(+) GGCCCA/TGTGAA 1 -- spa10--------

    HapMap Linkage Disequilibrium report for SYNE4 (36494002 - 36499695 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SYNE4: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SYNE4
    DNA2.0 Custom Variant and Variant Library Synthesis for SYNE4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SYNE4 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with SYNE4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    3. The LINC complex is essential for hearing. (PubMed id 23348741)1 Horn H.F....Avraham K.B. (2013)
    4. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    5. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 163183 HGNC: 26703 AceView: FLJ36445 Ensembl:ENSG00000181392 euGenes: HUgn163183
    ECgene: SYNE4 H-InvDB: SYNE4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SYNE4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SYNE4 gene:
    Search GeneIP for patents involving SYNE4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SYNE4  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for SYNE4  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SYNE4  
     OriGene qSTAR qPCR primer pairs in human, mouse for SYNE4   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for SYNE4   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SYNE4   OriGene Custom Protein Services for SYNE4  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SYNE4
     QIAGEN SeqTarget long-range PCR primers for resequencing SYNE4
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SYNE4
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SYNE4
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SYNE4
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SYNE4
     GenScript Custom Purified and Recombinant Proteins Services for SYNE4 GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for SYNE4
     GenScript Custom Assay Services for SYNE4 GenScript Custom Superior Antibodies Services for SYNE4
     GenScript Custom overexpressing Cell Line Services for SYNE4 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Search Regulatory tfbs for SYNE4
     Search Chromatin IP Primers for SYNE4
     Search RT2 qPCR Primer Assays in human, mouse, rat SYNE4
     Search GNC Networks for SYNE4
     SABiosciences Custom PCR Arrays for SYNE4
     Search Tocris compounds for SYNE4
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SYNE4 antibodies
     SYNE4 proteins
     SYNE4 lysates
     Antibodies for SYNE4
     See all of Abcam's Antibodies, Kits and Proteins for SYNE4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for SYNE4
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYNE4
     Browse SwitchGear 3'UTR luciferase reporter plasmids for SYNE4
     Browse SwitchGear Promoter luciferase reporter plasmids for SYNE4
     ThermoFisher Antibodies for SYNE4
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYNE4
     inGenious Targeting Laboratory - Custom generated mouse model solutions for SYNE4
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SYNE4
    Customized:
     lentivirus for stable overexpression of SYNE4
     lentivirus expression plasmids for stable overexpression of SYNE4
     adenovirus for overexpression of SYNE4
     LSBio Antibodies in human, mouse, rat for SYNE4
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SYNE4 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4