SYNE4 Gene
protein-coding GIFtS: 38
GCID: GC19M036496
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spectrin repeat containing, nuclear envelope family member...(Previous name: chromosome 19 open reading frame 46 )
(Previous symbol: C19orf46)
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Aliases
for SYNE4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Spectrin Repeat Containing, Nuclear Envelope Family Member 41 2 | | FLJ364451 | | C19orf461 2 3 | | Nesprin-41 | | Nesp41 2 | | Chromosome 19 Open Reading Frame 461 | | Nuclear Envelope Spectrin Repeat Protein 42 3 | | Nesprin-41 |
Export aliases for SYNE4 gene to outside databases |
Summaries
for SYNE4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: SYNE4_HUMAN, Q8N205Function: Contributes to the establishment of secretory epithelial morphology by promoting kinesin-dependent apicalmigration of the centrosome and Golgi apparatus and basal localization of the nucleus (By similarity)
|
Genomic Views
for SYNE4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for SYNE4
Other transcription factors
Search SABiosciences Chromatin IP Primers for SYNE4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SYNE4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.12 Ensembl cytogenetic band: 19q13.12 HGNC cytogenetic band: 19q13.12SYNE4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M036496: view genomic region
(about GC identifiers)
Start:
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36,494,002 bp from pter |
End:
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36,499,695 bp from pter |
Size:
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5,694 bases |
Orientation:
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minus strand |
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Proteins
for SYNE4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SYNE4_HUMAN, Q8N205 (See
protein sequence)Recommended Name: Nesprin-4 Size: 404 amino acids; 43512 Da
Subunit: Interacts with KIF5B and KCL1 (By similarity)
Subcellular location: Nucleus outer membrane; Single-pass type IV membrane protein (By similarity). Note=The nucleusouter membrane location requires the presence of a SUN domain-containing protein (By similarity)
Sequence caution: Sequence=BAC04222.1; Type=Miscellaneous discrepancy; Note=Intron retention;
Secondary accessions: A8MRS0 A8MYE3 Q7Z7L3Alternative splicing: 2 isoforms: Q8N205-1 Q8N205-2 Explore the universe of human proteins at neXtProt for SYNE4: NX_Q8N205
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8N205
SYNE4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001034965.1
ENSEMBL proteins: ENSP00000380572 ENSP00000425550 ENSP00000343152 ENSP00000316130 ENSP00000422716
Human Recombinant Protein Products for SYNE4:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0031309 | integral to nuclear outer membrane |
ISS | -- |
SYNE4 for ontologies About GeneDecksing
SYNE4 Antibody Products:
Assay Products for SYNE4: |
Protein
Domains /
Families
for SYNE4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SYNE4 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8N205ProtoNet protein and cluster: Q8N205 UniProtKB/Swiss-Prot: SYNE4_HUMAN, Q8N205Domain: The KASH domain, which contains a transmembrane domain, mediates the nuclear envelope targeting and is involvedin the binding to SUN1 and SUN2 through recognition of their SUN domains (By similarity)Similarity: Belongs to the nesprin familySimilarity: Contains 1 KASH domain |
Function
for SYNE4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: SYNE4_HUMAN, Q8N205Function: Contributes to the establishment of secretory epithelial morphology by promoting kinesin-dependent apicalmigration of the centrosome and Golgi apparatus and basal localization of the nucleus (By similarity) Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
SYNE4 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SYNE4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SYNE4 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for SYNE4 | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SYNE4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYNE4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYNE4 |
|
Pathways & Interactions
for SYNE4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SYNE4
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
5/10 Interacting proteins for SYNE4 (Q8N2052, 3 ENSP000003161304) via UniProtKB, MINT, STRING, and/or I2D (see all 10)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0045198 | establishment of epithelial cell apical/basal polarity |
ISS | -- |
SYNE4 for ontologies About GeneDecksing
|
Drugs & Compounds
for SYNE4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SYNE4
Search CenterWatch for drugs/clinical trials and news about SYNE4
|
Transcripts
for SYNE4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SYNE4 gene (2 alternative transcripts): NM_153233.1 NM_001039876.1 Unigene Cluster for SYNE4: Spectrin repeat containing, nuclear envelope family member 4 Hs.436743 [show with all ESTs]Unigene Representative Sequence: NM_0010398767 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000505054 ENST00000397428 ENST00000503121 ENST00000340477(uc021utd.1 uc002ocs.1)
ENST00000324444(uc002ocq.1 uc010een.1) ENST00000465425 ENST00000490730(uc002ocr.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SYNE4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SYNE4 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for SYNE4 | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SYNE4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYNE4 |
Additional cDNA sequence: BC038360.1 BC052573.1 5 DOTS entries: DT.100752167 DT.86847338 DT.100021380 DT.101981153 DT.121452927 24/29 AceView cDNA sequences (see all 29): AI244887 AW016070 AA827649 AK093764 AX748293 BC038360 CR595098 AW299369 NM_153233 AI088309 CB241656 AI052236 CB052141 BX115848 BG740714 BF434490 AL541773 BM980299 BM976898 BU538399 BC052573 AW615387 AA991508 AV750009
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for SYNE4 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b |
|---|
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| SP1: | | | | | | | - | | - | | - | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | - | | - | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SYNE4
|
Expression
for SYNE4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --
See SYNE4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SYNE4
SOURCE GeneReport for Unigene cluster: Hs.436743
SABiosciences Custom PCR Arrays for SYNE4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SYNE4
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat SYNE4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SYNE4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SYNE4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYNE4 |
Orthologs
for SYNE4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of human and mouse.
Orthologs for SYNE4 gene from 1/6 species (see all 6) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Syne41 , 5 |
expressed sequence AI4289365
spectrin repeat containing, nuclear envelope family more1 |
77.06(n)1
68.81(a)1 |
|
7 (17.39 cM)5
2330661 NM_153577.21 NP_705805.11
303148075 |
ENSEMBL Gene Tree for SYNE4 (if available)
TreeFam Gene Tree for SYNE4 (if available) |
Paralogs
for SYNE4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for SYNE4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SYNE4 (36494002 - 36499695 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SYNE4: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SYNE4 |
|
Disorders
/ Diseases
for SYNE4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for SYNE4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SYNE4 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SYNE4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
|
External Searches for SYNE4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SYNE4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SYNE4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SYNE4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SYNE4 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SYNE4 gene:
Search GeneIP for patents involving SYNE4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SYNE4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SYNE4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SYNE4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SYNE4 | | | OriGene Protein Over-expression Lysate for SYNE4 | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for SYNE4 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SYNE4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SYNE4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SYNE4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SYNE4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SYNE4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SYNE4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SYNE4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SYNE4 |
| |
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| | | | Search Tocris compounds for SYNE4 |
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 | | | SYNE4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYNE4 |
|  |  |  |  | | | | ThermoFisher Antibody for SYNE4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYNE4 |
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