Aliases for SYNE2 Gene
External Ids for SYNE2 Gene
The protein encoded by this gene is a nuclear outer membrane protein that binds cytoplasmic F-actin. This binding tethers the nucleus to the cytoskeleton and aids in the maintenance of the structural integrity of the nucleus. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
GeneCards Summary for SYNE2 Gene
SYNE2 (Spectrin Repeat Containing, Nuclear Envelope 2) is a Protein Coding gene. Diseases associated with SYNE2 include emery-dreifuss muscular dystrophy 5, autosomal dominant and syne2-related emery-dreifuss muscular dystrophy. Among its related pathways are Cell Cycle, Mitotic and Meiosis. GO annotations related to this gene include actin binding. An important paralog of this gene is ACTN2.
UniProtKB/Swiss-Prot for SYNE2 Gene
Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Involved in the maintenance of nuclear organization and structural integrity. Connects nuclei to the cytoskeleton by interacting with the nuclear envelope and with F-actin in the cytoplasm. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for centrosome migration to the apical cell surface during early ciliogenesis.