SYNDIG1L Gene
protein-coding GIFtS: 35
GCID: GC14M074873
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|
synapse differentiation inducing 1-like(Previous name: transmembrane protein 90A )
(Previous symbol: TMEM90A)
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Aliases
for SYNDIG1L gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Synapse Differentiation Inducing 1-Like1 2 | | Capucin3 | | TMEM90A1 2 3 5 | | Caudate- And Putamen-Enriched Sequence2 | | Transmembrane Protein 90A1 2 3 | | Caudate-And Putamen-Enriched Sequence2 | | IFITMD41 2 | | Interferon Induced Transmembrane Protein Domain Containing 42 | | Dispanin Subfamily C Member 12 3 | | Synapse Differentiation-Inducing Gene Protein 1-Like2 | | DSPC12 3 | | Capucin3 | | CAPUCIN2 5 | | |
Export aliases for SYNDIG1L gene to outside databases |
Summaries
for SYNDIG1L gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for SYNDIG1L gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000014.8 NC_018925.1 NT_026437.12
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for SYNDIG1L
Other transcription factors
Search SABiosciences Chromatin IP Primers for SYNDIG1L
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SYNDIG1L |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q24.3 Ensembl cytogenetic band: 14q24.3 HGNC cytogenetic band: 14q24.3SYNDIG1L Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14M074873: view genomic region
(about GC identifiers)
Start:
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74,872,596 bp from pter |
End:
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74,892,805 bp from pter |
Size:
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20,210 bases |
Orientation:
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minus strand |
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Proteins
for SYNDIG1L gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SYN1L_HUMAN, A6NDD5 (See
protein sequence)Recommended Name: Synapse differentiation-inducing gene protein 1-like Size: 238 amino acids; 25796 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential). Golgi apparatus, cis-Golgi network (Bysimilarity)Explore the universe of human proteins at neXtProt for SYNDIG1L: NX_A6NDD5
SYNDIG1L Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001099049.1
ENSEMBL proteins: ENSP00000450439 ENSP00000451519 ENSP00000331474
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005794 | Golgi apparatus |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
SYNDIG1L for ontologies About GeneDecksing
SYNDIG1L Antibody Products:
Assay Products for SYNDIG1L: |
Protein
Domains /
Families
for SYNDIG1L gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SYNDIG1L for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry A6NDD5ProtoNet protein and cluster: A6NDD5 UniProtKB/Swiss-Prot: SYN1L_HUMAN, A6NDD5Similarity: Belongs to the CD225/Dispanin family |
Function
for SYNDIG1L gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SYNDIG1L (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SYNDIG1L
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for SYNDIG1L | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SYNDIG1L | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SYNDIG1L |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYNDIG1L |
Animal Models:
Mouse knock-out Syndig1ltm1Embr for SYNDIG1L
2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Syndig1l):
SYNDIG1L for phenotypes About GeneDecksing
|
Pathways & Interactions
for SYNDIG1L gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SYNDIG1L
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0009607 | response to biotic stimulus |
IEA | -- |
SYNDIG1L for ontologies About GeneDecksing
|
Drugs & Compounds
for SYNDIG1L gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SYNDIG1L
Search CenterWatch for drugs/clinical trials and news about SYNDIG1L / SYN1L
|
Transcripts
for SYNDIG1L gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SYNDIG1L gene: NM_001105579.1 Unigene Cluster for SYNDIG1L: Synapse differentiation inducing 1-like Hs.12400 [show with all ESTs]Unigene Representative Sequence: NM_0011055793 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000554823 ENST00000554953 ENST00000331628(uc001xpx.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SYNDIG1L (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SYNDIG1L
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for SYNDIG1L | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SYNDIG1L | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SYNDIG1L |
Additional cDNA sequence: AK094873.1 BC030107.2 BC045804.1 3 DOTS entries: DT.427170 DT.106401 DT.95184328
GeneLoc Exon Structure
|
Expression
for SYNDIG1L gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SYNDIG1L expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCCCATCCAG
About this image
See SYNDIG1L Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SYNDIG1L
SOURCE GeneReport for Unigene cluster: Hs.12400
SABiosciences Custom PCR Arrays for SYNDIG1L
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SYNDIG1L
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SYNDIG1L | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SYNDIG1L | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SYNDIG1L | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYNDIG1L |
Orthologs
for SYNDIG1L gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for SYNDIG1L gene from 3/9 species (see all 9) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
SYNDIG1L1 |
synapse differentiation inducing 1-like |
67.97(n)
60.87(a) |
|
423351 XM_421266.3 XP_421266.1 |
lizard
(Anolis carolinensis) |
Reptilia |
SYNDIG1L6 |
-- |
59(a) |
1 ↔ 1 |
1(23389143-23407568) |
zebrafish
(Danio rerio) |
Actinopterygii |
syndig1l1 |
synapse differentiation inducing 1-like |
62.75(n)
57.39(a) |
|
555204 NM_001044781.1 NP_001038246.1 |
ENSEMBL Gene Tree for SYNDIG1L (if available)
TreeFam Gene Tree for SYNDIG1L (if available) |
Paralogs
for SYNDIG1L gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SYNDIG1L gene
- TMEM912 SYNDIG12
2 SIMAP similar genes for SYNDIG1L using alignment to 2 protein entries: SYN1L_HUMAN (see all proteins):SYNDIG1 TMEM91
SYNDIG1L for paralogs About GeneDecksing
|
Genomic Variants
for SYNDIG1L gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 14 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SYNDIG1L (74872596 - 74892805 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SYNDIG1L: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SYNDIG1L |
|
Disorders
/ Diseases
for SYNDIG1L gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SYNDIG1L for disorders About GeneDecksing
OMIM gene information: 609999
OMIM disorders: --
1  disease for SYNDIG1L: About MalaCardshuntington's disease
Export disorders for SYNDIG1L gene to outside databases
|
Publications
for SYNDIG1L gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SYNDIG1L gene integrated from 9 sources:
(articles sorted by number of sources associating them with SYNDIG1L) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Capucin: a novel striatal marker down-regulated in rodent models of Huntington disease. (PubMed id 16359841)1, 2, 3 de Chaldee M....Elalouf J.M. (2006)
- The dispanins: a novel gene family of ancient origin that contains 14 human members. (PubMed id 22363774)2 Sallman Almen M.... Schioth H.B. (2012)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)2 Heilig R.... Weissenbach J. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for SYNDIG1L gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing SYNDIG1L gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SYNDIG1L gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SYNDIG1L gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SYNDIG1L | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for SYNDIG1L gene:
Search GeneIP for patents involving SYNDIG1L
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SYNDIG1L gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SYNDIG1L | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SYNDIG1L | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SYNDIG1L | | | OriGene Protein Over-expression Lysate for SYNDIG1L | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SYNDIG1L | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SYNDIG1L | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SYNDIG1L | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SYNDIG1L | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SYNDIG1L | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SYNDIG1L | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SYNDIG1L | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SYNDIG1L | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SYNDIG1L |
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 | | | SYNDIG1L Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYNDIG1L |
|  |  |  | | | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SYNDIG1L |
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