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Aliases for SYNDIG1L Gene

Aliases for SYNDIG1L Gene

  • Synapse Differentiation Inducing 1 Like 2 3
  • Transmembrane Protein 90A 2 3 4
  • Interferon Induced Transmembrane Protein Domain Containing 4 2 3
  • Synapse Differentiation Inducing 1-Like 3 5
  • Caudate-And Putamen-Enriched Sequence 2 3
  • Dispanin Subfamily C Member 1 3 4
  • CAPUCIN 3 4
  • TMEM90A 3 4
  • DSPC1 3 4
  • Caudate- And Putamen-Enriched Sequence 3
  • IFITMD4 3

External Ids for SYNDIG1L Gene

Previous HGNC Symbols for SYNDIG1L Gene

  • TMEM90A

Previous GeneCards Identifiers for SYNDIG1L Gene

  • GC14M074873

Summaries for SYNDIG1L Gene

GeneCards Summary for SYNDIG1L Gene

SYNDIG1L (Synapse Differentiation Inducing 1 Like) is a Protein Coding gene. An important paralog of this gene is SYNDIG1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYNDIG1L Gene

Genomics for SYNDIG1L Gene

Regulatory Elements for SYNDIG1L Gene

Enhancers for SYNDIG1L Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SYNDIG1L on UCSC Golden Path with GeneCards custom track

Genomic Location for SYNDIG1L Gene

Chromosome:
14
Start:
74,405,893 bp from pter
End:
74,437,631 bp from pter
Size:
31,739 bases
Orientation:
Minus strand

Genomic View for SYNDIG1L Gene

Genes around SYNDIG1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SYNDIG1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SYNDIG1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYNDIG1L Gene

Proteins for SYNDIG1L Gene

  • Protein details for SYNDIG1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NDD5-SYN1L_HUMAN
    Recommended name:
    Synapse differentiation-inducing gene protein 1-like
    Protein Accession:
    A6NDD5

    Protein attributes for SYNDIG1L Gene

    Size:
    238 amino acids
    Molecular mass:
    25796 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SYNDIG1L Gene

Proteomics data for SYNDIG1L Gene at MOPED

Post-translational modifications for SYNDIG1L Gene

No Post-translational modifications

Other Protein References for SYNDIG1L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SYNDIG1L Gene

Domains & Families for SYNDIG1L Gene

Protein Domains for SYNDIG1L Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SYNDIG1L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NDD5

UniProtKB/Swiss-Prot:

SYN1L_HUMAN :
  • Belongs to the CD225/Dispanin family.
Family:
  • Belongs to the CD225/Dispanin family.
genes like me logo Genes that share domains with SYNDIG1L: view

No data available for Gene Families for SYNDIG1L Gene

Function for SYNDIG1L Gene

Phenotypes for SYNDIG1L Gene

MGI mutant phenotypes for SYNDIG1L:
inferred from 1 alleles
GenomeRNAi human phenotypes for SYNDIG1L:
genes like me logo Genes that share phenotypes with SYNDIG1L: view

Animal Models for SYNDIG1L Gene

MGI Knock Outs for SYNDIG1L:

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SYNDIG1L Gene

Localization for SYNDIG1L Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYNDIG1L Gene

Membrane; Multi-pass membrane protein. Golgi apparatus, cis-Golgi network.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SYNDIG1L Gene COMPARTMENTS Subcellular localization image for SYNDIG1L gene
Compartment Confidence
golgi apparatus 4
plasma membrane 3

Gene Ontology (GO) - Cellular Components for SYNDIG1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SYNDIG1L: view

Pathways & Interactions for SYNDIG1L Gene

SuperPathways for SYNDIG1L Gene

No Data Available

Interacting Proteins for SYNDIG1L Gene

Gene Ontology (GO) - Biological Process for SYNDIG1L Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SYNDIG1L Gene

Drugs & Compounds for SYNDIG1L Gene

No Compound Related Data Available

Transcripts for SYNDIG1L Gene

mRNA/cDNA for SYNDIG1L Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SYNDIG1L Gene

Synapse differentiation inducing 1-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SYNDIG1L Gene

No ASD Table

Relevant External Links for SYNDIG1L Gene

GeneLoc Exon Structure for
SYNDIG1L
ECgene alternative splicing isoforms for
SYNDIG1L

Expression for SYNDIG1L Gene

mRNA expression in normal human tissues for SYNDIG1L Gene

mRNA differential expression in normal tissues according to GTEx for SYNDIG1L Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x20.6), Brain - Caudate (basal ganglia) (x16.2), and Brain - Nucleus accumbens (basal ganglia) (x13.0).

SOURCE GeneReport for Unigene cluster for SYNDIG1L Gene Hs.12400

genes like me logo Genes that share expression patterns with SYNDIG1L: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SYNDIG1L Gene

Orthologs for SYNDIG1L Gene

This gene was present in the common ancestor of chordates.

Orthologs for SYNDIG1L Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SYNDIG1L 35
  • 87.34 (n)
  • 88.61 (a)
SYNDIG1L 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SYNDIG1L 35
  • 87.11 (n)
  • 86.13 (a)
SYNDIG1L 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Syndig1l 35
  • 86.22 (n)
  • 87.76 (a)
Syndig1l 16
Syndig1l 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SYNDIG1L 35
  • 98.32 (n)
  • 97.06 (a)
SYNDIG1L 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Syndig1l 35
  • 86.92 (n)
  • 88.19 (a)
oppossum
(Monodelphis domestica)
Mammalia SYNDIG1L 36
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves SYNDIG1L 35
  • 68.55 (n)
  • 60.87 (a)
SYNDIG1L 36
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SYNDIG1L 36
  • 59 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii syndig1l 35
  • 62.03 (n)
  • 56.52 (a)
syndig1l 36
  • 41 (a)
OneToOne
Species with no ortholog for SYNDIG1L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SYNDIG1L Gene

ENSEMBL:
Gene Tree for SYNDIG1L (if available)
TreeFam:
Gene Tree for SYNDIG1L (if available)

Paralogs for SYNDIG1L Gene

Paralogs for SYNDIG1L Gene

(2) SIMAP similar genes for SYNDIG1L Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SYNDIG1L: view

Variants for SYNDIG1L Gene

Sequence variations from dbSNP and Humsavar for SYNDIG1L Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs7140692 -- 74,434,484(+) AGCAG(C/T)GGGGA intron-variant
rs7142620 -- 74,410,918(+) ATCCC(A/G)TTTGG intron-variant
rs8017444 -- 74,413,255(+) CTTGG(A/G)CTCTG intron-variant
rs8003322 -- 74,434,937(+) AATTA(C/G)CCGGG intron-variant
rs8003971 -- 74,420,895(+) AGAGA(A/G)GCCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SYNDIG1L Gene

Variant ID Type Subtype PubMed ID
nsv832829 CNV Loss 17160897
esv33960 CNV Gain 17666407

Variation tolerance for SYNDIG1L Gene

Residual Variation Intolerance Score: 73% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.56; 72.19% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SYNDIG1L Gene

Disorders for SYNDIG1L Gene

Relevant External Links for SYNDIG1L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SYNDIG1L

No disorders were found for SYNDIG1L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SYNDIG1L Gene

Publications for SYNDIG1L Gene

  1. Capucin: a novel striatal marker down-regulated in rodent models of Huntington disease. (PMID: 16359841) de Chaldee M. … Elalouf J.-M. (Genomics 2006) 2 3 4 67
  2. The dispanins: a novel gene family of ancient origin that contains 14 human members. (PMID: 22363774) Sallman Almen M. … Schioth H.B. (PLoS ONE 2012) 3
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for SYNDIG1L Gene

Sources for SYNDIG1L Gene

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