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Aliases for SYNDIG1L Gene

Aliases for SYNDIG1L Gene

  • Synapse Differentiation Inducing 1 Like 2 3 5
  • Transmembrane Protein 90A 2 3 4
  • Interferon Induced Transmembrane Protein Domain Containing 4 2 3
  • Dispanin Subfamily C Member 1 3 4
  • CAPUCIN 3 4
  • TMEM90A 3 4
  • DSPC1 3 4
  • Synapse Differentiation-Inducing Gene Protein 1-Like 3
  • Caudate- And Putamen-Enriched Sequence 3
  • Caudate-And Putamen-Enriched Sequence 2
  • IFITMD4 3

External Ids for SYNDIG1L Gene

Previous HGNC Symbols for SYNDIG1L Gene

  • TMEM90A

Previous GeneCards Identifiers for SYNDIG1L Gene

  • GC14M074873

Summaries for SYNDIG1L Gene

GeneCards Summary for SYNDIG1L Gene

SYNDIG1L (Synapse Differentiation Inducing 1 Like) is a Protein Coding gene. An important paralog of this gene is SYNDIG1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYNDIG1L Gene

Genomics for SYNDIG1L Gene

Regulatory Elements for SYNDIG1L Gene

Enhancers for SYNDIG1L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around SYNDIG1L on UCSC Golden Path with GeneCards custom track

Genomic Location for SYNDIG1L Gene

74,405,893 bp from pter
74,437,631 bp from pter
31,739 bases
Minus strand

Genomic View for SYNDIG1L Gene

Genes around SYNDIG1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SYNDIG1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SYNDIG1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYNDIG1L Gene

Proteins for SYNDIG1L Gene

  • Protein details for SYNDIG1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Synapse differentiation-inducing gene protein 1-like
    Protein Accession:

    Protein attributes for SYNDIG1L Gene

    238 amino acids
    Molecular mass:
    25796 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SYNDIG1L Gene

Post-translational modifications for SYNDIG1L Gene

No Post-translational modifications

Other Protein References for SYNDIG1L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SYNDIG1L Gene

Domains & Families for SYNDIG1L Gene

Protein Domains for SYNDIG1L Gene


Suggested Antigen Peptide Sequences for SYNDIG1L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CD225/Dispanin family.
  • Belongs to the CD225/Dispanin family.
genes like me logo Genes that share domains with SYNDIG1L: view

No data available for Gene Families for SYNDIG1L Gene

Function for SYNDIG1L Gene

Phenotypes for SYNDIG1L Gene

MGI mutant phenotypes for SYNDIG1L:
inferred from 1 alleles
GenomeRNAi human phenotypes for SYNDIG1L:
genes like me logo Genes that share phenotypes with SYNDIG1L: view

Animal Models for SYNDIG1L Gene

MGI Knock Outs for SYNDIG1L:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SYNDIG1L Gene

Localization for SYNDIG1L Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYNDIG1L Gene

Membrane; Multi-pass membrane protein. Golgi apparatus, cis-Golgi network.

Subcellular locations from

Jensen Localization Image for SYNDIG1L Gene COMPARTMENTS Subcellular localization image for SYNDIG1L gene
Compartment Confidence
golgi apparatus 4
plasma membrane 3

Gene Ontology (GO) - Cellular Components for SYNDIG1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SYNDIG1L: view

Pathways & Interactions for SYNDIG1L Gene

SuperPathways for SYNDIG1L Gene

No Data Available

Interacting Proteins for SYNDIG1L Gene

Gene Ontology (GO) - Biological Process for SYNDIG1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009607 response to biotic stimulus IEA --
genes like me logo Genes that share ontologies with SYNDIG1L: view

No data available for Pathways by source and SIGNOR curated interactions for SYNDIG1L Gene

Drugs & Compounds for SYNDIG1L Gene

No Compound Related Data Available

Transcripts for SYNDIG1L Gene


(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SYNDIG1L Gene

Synapse differentiation inducing 1-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SYNDIG1L Gene

No ASD Table

Relevant External Links for SYNDIG1L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SYNDIG1L Gene

mRNA expression in normal human tissues for SYNDIG1L Gene

mRNA differential expression in normal tissues according to GTEx for SYNDIG1L Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x20.6), Brain - Caudate (basal ganglia) (x16.2), and Brain - Nucleus accumbens (basal ganglia) (x13.0).

NURSA nuclear receptor signaling pathways regulating expression of SYNDIG1L Gene:


SOURCE GeneReport for Unigene cluster for SYNDIG1L Gene:

genes like me logo Genes that share expression patterns with SYNDIG1L: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for SYNDIG1L Gene

Orthologs for SYNDIG1L Gene

This gene was present in the common ancestor of chordates.

Orthologs for SYNDIG1L Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SYNDIG1L 34
  • 87.34 (n)
  • 88.61 (a)
  • 89 (a)
(Canis familiaris)
Mammalia SYNDIG1L 34
  • 87.11 (n)
  • 86.13 (a)
  • 87 (a)
(Mus musculus)
Mammalia Syndig1l 34
  • 86.22 (n)
  • 87.76 (a)
Syndig1l 16
Syndig1l 35
  • 89 (a)
(Pan troglodytes)
Mammalia SYNDIG1L 34
  • 98.32 (n)
  • 97.06 (a)
  • 96 (a)
(Rattus norvegicus)
Mammalia Syndig1l 34
  • 86.92 (n)
  • 88.19 (a)
(Monodelphis domestica)
Mammalia SYNDIG1L 35
  • 64 (a)
(Gallus gallus)
Aves SYNDIG1L 34
  • 68.55 (n)
  • 60.87 (a)
  • 58 (a)
(Anolis carolinensis)
Reptilia SYNDIG1L 35
  • 59 (a)
(Danio rerio)
Actinopterygii syndig1l 34
  • 62.03 (n)
  • 56.52 (a)
syndig1l 35
  • 41 (a)
Species where no ortholog for SYNDIG1L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SYNDIG1L Gene

Gene Tree for SYNDIG1L (if available)
Gene Tree for SYNDIG1L (if available)

Paralogs for SYNDIG1L Gene

Paralogs for SYNDIG1L Gene

(2) SIMAP similar genes for SYNDIG1L Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SYNDIG1L: view

Variants for SYNDIG1L Gene

Sequence variations from dbSNP and Humsavar for SYNDIG1L Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs2569 -- 74,406,153(+) GCCTA(A/C)CTGGA utr-variant-3-prime
rs7140692 -- 74,434,484(+) AGCAG(C/T)GGGGA intron-variant
rs7142620 -- 74,410,918(+) ATCCC(A/G)TTTGG intron-variant
rs7144263 -- 74,438,928(+) GCCAA(C/T)ATCAT upstream-variant-2KB
rs7144757 -- 74,439,169(+) TCTTT(C/T)CCCAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SYNDIG1L Gene

Variant ID Type Subtype PubMed ID
esv33960 CNV gain 17666407
nsv832829 CNV loss 17160897

Variation tolerance for SYNDIG1L Gene

Residual Variation Intolerance Score: 73% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.56; 72.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SYNDIG1L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SYNDIG1L Gene

Disorders for SYNDIG1L Gene

Relevant External Links for SYNDIG1L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SYNDIG1L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SYNDIG1L Gene

Publications for SYNDIG1L Gene

  1. Capucin: a novel striatal marker down-regulated in rodent models of Huntington disease. (PMID: 16359841) de Chaldee M. … Elalouf J.-M. (Genomics 2006) 2 3 4 65
  2. The dispanins: a novel gene family of ancient origin that contains 14 human members. (PMID: 22363774) Sallman Almen M. … Schioth H.B. (PLoS ONE 2012) 3 4 65
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 65
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 65
  5. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R. … Weissenbach J. (Nature 2003) 4 65

Products for SYNDIG1L Gene

Sources for SYNDIG1L Gene

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