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Aliases for SYNDIG1 Gene

Aliases for SYNDIG1 Gene

  • Synapse Differentiation Inducing 1 2 3 5
  • Transmembrane Protein 90B 2 3 4
  • Interferon Induced Transmembrane Protein Domain Containing 5 2 3
  • Synapse Differentiation Induced Gene 1 2 3
  • Dispanin Subfamily C Member 2 3 4
  • C20orf39 3 4
  • TMEM90B 3 4
  • DSPC2 3 4
  • Synapse Differentiation-Inducing Gene Protein 1 3
  • Chromosome 20 Open Reading Frame 39 2
  • IFITMD5 3
  • SynDIG1 4

External Ids for SYNDIG1 Gene

Previous HGNC Symbols for SYNDIG1 Gene

  • C20orf39
  • TMEM90B

Summaries for SYNDIG1 Gene

Entrez Gene Summary for SYNDIG1 Gene

  • This gene encodes a protein that belongs to the interferon-induced transmembrane family of proteins. A similar protein in rat is thought to regulate the development of excitatory synapses. [provided by RefSeq, Jul 2013]

GeneCards Summary for SYNDIG1 Gene

SYNDIG1 (Synapse Differentiation Inducing 1) is a Protein Coding gene. GO annotations related to this gene include protein homodimerization activity and glutamate receptor binding. An important paralog of this gene is SYNDIG1L.

UniProtKB/Swiss-Prot for SYNDIG1 Gene

  • May regulate AMPA receptor content at nascent synapses, and have a role in postsynaptic development and maturation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYNDIG1 Gene

Genomics for SYNDIG1 Gene

Regulatory Elements for SYNDIG1 Gene

Enhancers for SYNDIG1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around SYNDIG1 on UCSC Golden Path with GeneCards custom track

Promoters for SYNDIG1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for SYNDIG1 Gene

Chromosome:
20
Start:
24,469,199 bp from pter
End:
24,666,617 bp from pter
Size:
197,419 bases
Orientation:
Plus strand

Genomic View for SYNDIG1 Gene

Genes around SYNDIG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SYNDIG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SYNDIG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYNDIG1 Gene

Proteins for SYNDIG1 Gene

  • Protein details for SYNDIG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H7V2-SYNG1_HUMAN
    Recommended name:
    Synapse differentiation-inducing gene protein 1
    Protein Accession:
    Q9H7V2
    Secondary Accessions:
    • Q6IA30
    • Q9H514

    Protein attributes for SYNDIG1 Gene

    Size:
    258 amino acids
    Molecular mass:
    28551 Da
    Quaternary structure:
    • Homodimer. Interacts with GRIA1 and GRIA2 (By similarity).

neXtProt entry for SYNDIG1 Gene

Post-translational modifications for SYNDIG1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SYNDIG1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SYNDIG1 Gene

Domains & Families for SYNDIG1 Gene

Protein Domains for SYNDIG1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SYNDIG1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H7V2

UniProtKB/Swiss-Prot:

SYNG1_HUMAN :
  • Belongs to the CD225/Dispanin family.
Family:
  • Belongs to the CD225/Dispanin family.
genes like me logo Genes that share domains with SYNDIG1: view

No data available for Gene Families for SYNDIG1 Gene

Function for SYNDIG1 Gene

Molecular function for SYNDIG1 Gene

UniProtKB/Swiss-Prot Function:
May regulate AMPA receptor content at nascent synapses, and have a role in postsynaptic development and maturation.

Gene Ontology (GO) - Molecular Function for SYNDIG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0035254 glutamate receptor binding IEA,ISS --
GO:0042803 protein homodimerization activity IEA,ISS --
genes like me logo Genes that share ontologies with SYNDIG1: view

Phenotypes for SYNDIG1 Gene

GenomeRNAi human phenotypes for SYNDIG1:
genes like me logo Genes that share phenotypes with SYNDIG1: view

Animal Model Products

CRISPR Products

miRNA for SYNDIG1 Gene

miRTarBase miRNAs that target SYNDIG1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SYNDIG1 Gene

Localization for SYNDIG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYNDIG1 Gene

Cell membrane; Single-pass type II membrane protein. Early endosome membrane; Single-pass type II membrane protein. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse. Cell projection, dendrite. Cell projection, dendritic spine. Note=Shuttles between the cell surface and early endosome membrane. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SYNDIG1 Gene COMPARTMENTS Subcellular localization image for SYNDIG1 gene
Compartment Confidence
plasma membrane 5
endosome 4
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SYNDIG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IEA,ISS --
GO:0014069 postsynaptic density IEA,ISS --
GO:0030054 cell junction IEA --
GO:0031901 early endosome membrane IEA,ISS --
GO:0043197 dendritic spine IEA,ISS --
genes like me logo Genes that share ontologies with SYNDIG1: view

Pathways & Interactions for SYNDIG1 Gene

SuperPathways for SYNDIG1 Gene

No Data Available

Interacting Proteins for SYNDIG1 Gene

Gene Ontology (GO) - Biological Process for SYNDIG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IEA,ISS --
GO:0009607 response to biotic stimulus IEA --
GO:0051965 positive regulation of synapse assembly IEA,IDA 20152115
GO:0097091 synaptic vesicle clustering IEA,ISS --
genes like me logo Genes that share ontologies with SYNDIG1: view

No data available for Pathways by source and SIGNOR curated interactions for SYNDIG1 Gene

Drugs & Compounds for SYNDIG1 Gene

No Compound Related Data Available

Transcripts for SYNDIG1 Gene

mRNA/cDNA for SYNDIG1 Gene

Unigene Clusters for SYNDIG1 Gene

Synapse differentiation inducing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SYNDIG1 Gene

No ASD Table

Relevant External Links for SYNDIG1 Gene

GeneLoc Exon Structure for
SYNDIG1
ECgene alternative splicing isoforms for
SYNDIG1

Expression for SYNDIG1 Gene

mRNA expression in normal human tissues for SYNDIG1 Gene

mRNA differential expression in normal tissues according to GTEx for SYNDIG1 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.6), Brain - Cortex (x4.1), and Brain - Cerebellum (x4.0).

Protein differential expression in normal tissues from HIPED for SYNDIG1 Gene

This gene is overexpressed in Lung (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SYNDIG1 Gene



Protein tissue co-expression partners for SYNDIG1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SYNDIG1 Gene:

SYNDIG1

SOURCE GeneReport for Unigene cluster for SYNDIG1 Gene:

Hs.124638
genes like me logo Genes that share expression patterns with SYNDIG1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for SYNDIG1 Gene

Orthologs for SYNDIG1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SYNDIG1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SYNDIG1 34
  • 85.27 (n)
  • 86.43 (a)
SYNDIG1 35
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM90B 34
  • 90.57 (n)
  • 93.8 (a)
SYNDIG1 35
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Syndig1 34
  • 87.73 (n)
  • 93.02 (a)
Syndig1 16
Syndig1 35
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SYNDIG1 34
  • 99.74 (n)
  • 100 (a)
TMEM90B 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Syndig1 34
  • 87.98 (n)
  • 91.47 (a)
oppossum
(Monodelphis domestica)
Mammalia SYNDIG1 35
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SYNDIG1 35
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves SYNDIG1 34
  • 80.99 (n)
  • 86.33 (a)
SYNDIG1 35
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SYNDIG1 35
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia syndig1 34
  • 74.68 (n)
  • 82.56 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC792553 34
  • 73.25 (n)
  • 72.96 (a)
SYNDIG1 35
  • 63 (a)
OneToOne
Species where no ortholog for SYNDIG1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SYNDIG1 Gene

ENSEMBL:
Gene Tree for SYNDIG1 (if available)
TreeFam:
Gene Tree for SYNDIG1 (if available)

Paralogs for SYNDIG1 Gene

Paralogs for SYNDIG1 Gene

(1) SIMAP similar genes for SYNDIG1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SYNDIG1: view

Variants for SYNDIG1 Gene

Sequence variations from dbSNP and Humsavar for SYNDIG1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs6083553 - 24,543,257(+) GGGTG(A/G)GGGCC nc-transcript-variant, reference, missense
rs1467660 -- 24,504,889(+) CTGCA(A/C)TAGCC intron-variant
rs715863 -- 24,545,212(+) CGGGA(A/G)GCCCA intron-variant
rs719491 -- 24,497,300(+) AGTTC(A/G)AGCAA intron-variant
rs727409 -- 24,576,891(+) TTCTC(C/T)ACCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SYNDIG1 Gene

Variant ID Type Subtype PubMed ID
esv1529124 CNV insertion 17803354
esv2540968 CNV insertion 19546169
esv2651577 CNV insertion 19546169
esv2657114 CNV deletion 23128226
esv2662588 CNV deletion 23128226
esv2673324 CNV deletion 23128226
esv3378968 CNV insertion 20981092
esv3567926 CNV loss 25503493
esv3567927 CNV loss 25503493
esv3645551 CNV loss 21293372
esv3645552 CNV gain 21293372
esv3645553 CNV gain 21293372
esv3645554 CNV loss 21293372
esv3645555 CNV loss 21293372
esv990034 CNV loss 20482838
nsv1115598 CNV duplication 24896259
nsv178771 CNV deletion 16902084
nsv179076 CNV deletion 16902084
nsv513540 CNV insertion 21212237
nsv522873 CNV gain 19592680
nsv524920 CNV gain 19592680
nsv833946 CNV gain 17160897
nsv9793 CNV gain+loss 18304495

Variation tolerance for SYNDIG1 Gene

Residual Variation Intolerance Score: 66.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.90; 35.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SYNDIG1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SYNDIG1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SYNDIG1 Gene

Disorders for SYNDIG1 Gene

Relevant External Links for SYNDIG1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SYNDIG1

No disorders were found for SYNDIG1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SYNDIG1 Gene

Publications for SYNDIG1 Gene

  1. The dispanins: a novel gene family of ancient origin that contains 14 human members. (PMID: 22363774) Sallman Almen M. … Schioth H.B. (PLoS ONE 2012) 3 4 65
  2. SynDIG1: an activity-regulated, AMPA- receptor-interacting transmembrane protein that regulates excitatory synapse development. (PMID: 20152115) Kalashnikova E. … DA-az E. (Neuron 2010) 2 3 65
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  5. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4 65

Products for SYNDIG1 Gene

Sources for SYNDIG1 Gene

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