SYNCRIP Gene
protein-coding GIFtS: 52
GCID: GC06M086267
|
|
synaptotagmin binding, cytoplasmic RNA interacting protein
| |
Aliases
for SYNCRIP gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Synaptotagmin Binding, Cytoplasmic RNA Interacting Protein1 2 | | DJ3J17.21 | | GRY-RBP1 2 3 | | GRYRBP2 | | NSAP11 2 3 | | PP682 | | HNRPQ11 2 | | Heterogeneous Nuclear Ribonucleoprotein Q2 | | HnRNP-Q1 | | HNRPQ3 | | Glycine- And Tyrosine-Rich RNA-Binding Protein2 3 | | HnRNP Q3 | | NS1-Associated Protein 12 3 | | Synaptotagmin-Binding, Cytoplasmic RNA-Interacting Protein3 |
Export aliases for SYNCRIP gene to outside databasesPrevious GC identifers: GC06M086317 GC06M086318 GC06M086377 GC06M086380 GC06M083541 |
Summaries
for SYNCRIP gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SYNCRIP:
This gene encodes a member of the cellular heterogeneous nuclear ribonucleoprotein (hnRNP) family. hnRNPs are RNAbinding proteins that complex with heterogeneous nuclear RNA (hnRNA) and regulate alternative splicing,polyadenylation, and other aspects of mRNA metabolism and transport. The encoded protein plays a role in multipleaspects of mRNA maturation and is associated with several multiprotein complexes including the apoB RNAediting-complex and survival of motor neurons (SMN) complex. Alternatively spliced transcript variants encodingmultiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm ofchromosome 20. (provided by RefSeq, Dec 2011)
UniProtKB/Swiss-Prot: HNRPQ_HUMAN, O60506Function: Heterogenous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. Component of theCRD-mediated complex that promotes MYC mRNA stability. Isoform 1, isoform 2 and isoform 3 are associated in vitro withpre-mRNA, splicing intermediates and mature mRNA protein complexes. Isoform 1 binds to apoB mRNA AU-rich sequences.Isoform 1 is part of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of theAPOB mRNA through either by binding to A1CF (APOBEC1 complementation factor), to APOBEC1 or to RNA itself. May beinvolved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmicdeadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant ofinstability (mCRD) domain. Interacts in vitro preferentially with poly(A) and poly(U) RNA sequences. Isoform 3 may beinvolved in cytoplasmic vesicle-based mRNA transport through interaction with synaptotagmins. Component of the GAIT(gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-inducedtranscript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation assembles intothe GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (suchas ceruplasmin) and suppresses their translation; seems not to be essential for GAIT complex function
Gene Wiki entry for SYNCRIP
|
Genomic Views
for SYNCRIP gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007299.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SYNCRIP gene promoter:
AhR SRF Sp1 Egr-1 SRF (504 AA) HNF-4alpha2 Nkx2-5 Arnt HNF-4alpha1 Egr-4
Other transcription factors
Search SABiosciences Chromatin IP Primers for SYNCRIP
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SYNCRIP |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6q14-q15 Ensembl cytogenetic band: 6q14.3 HGNC cytogenetic band: 6q14-q15SYNCRIP Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M086267: view genomic region
(about GC identifiers)
Start:
|
86,267,696 bp from pter |
End:
|
86,353,510 bp from pter |
Size:
|
85,815 bases |
Orientation:
|
minus strand |
|
Proteins
for SYNCRIP gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: HNRPQ_HUMAN, O60506 (See
protein sequence)Recommended Name: Heterogeneous nuclear ribonucleoprotein Q Size: 623 amino acids; 69603 Da
Subunit: Isoform 1 is a component of the APOB mRNA editosome complex and interacts with APOBEC1 and A1CF (APOBEC1complementation factor). Part of a complex associated with the FOS mCRD domain and consisting of PABPC1, PAIP1,CSDE1/UNR, HNRPD and SYNCRIP. Isoform 3 interacts with HNRPR. Interacts with POLR2A hyperphosphorylated C-terminaldomain. Interacts with minute virus of mice (MVM) NS1 protein. Isoform 1, isoform 2 and isoform 3 interact with SMN.Isoform 3 interacts through its C-terminal domain with SYT7, SYT8 and SYT9 (By similarity). The non-phosphorylated andphosphorylated forms are colocalized with PAIP1 in polysomes (By similarity). Identified in a histone pre-mRNAcomplex, at least composed of ERI1, LSM11, SLBP, SNRPB, SYNCRIP and YBX1 (By similarity). Identified in thespliceosome C complex. Component of the coding region determinant (CRD)-mediated complex, composed of DHX9, HNRNPU,IGF2BP1, SYNCRIP and YBX1. Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1,ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1. Identified in a mRNP granule complex, at least composed ofACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2,ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 anduntranslated mRNAs. Interacts with GTPBP1. Component of the GAIT complex; in humans the complex assembly seems to be atwo-step process in which EPRS first associates with SYNCRIP to form a pre-GAIT complex which is deficient in GAITelement binding
Subcellular location: Cytoplasm. Microsome (By similarity). Endoplasmic reticulum (By similarity). Nucleus (Bysimilarity). Note=The tyrosine phosphorylated form bound to RNA is found in microsomes (By similarity). Localized incytoplasmic mRNP granules containing untranslated mRNAs
Subcellular location: Isoform 1: Nucleus, nucleoplasm (By similarity). Note=Expressed predominantly in the nucleoplasm(By similarity)
Subcellular location: Isoform 2: Nucleus, nucleoplasm (By similarity). Note=Expressed predominantly in the nucleoplasm(By similarity)
Subcellular location: Isoform 3: Nucleus, nucleoplasm (By similarity). Note=Expressed predominantly in the nucleoplasm(By similarity)
Sequence caution: Sequence=AAH15575.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-Asequence starting in position 413;
1 PDB 3D structure from  and Proteopedia  for SYNCRIP:2DGU (3D)
Secondary accessions: E1P501 E1P502 Q53H05 Q5TCG2 Q5TCG3 Q8IW78 Q8N599 Q96LC1 Q96LC2 Q9Y583Alternative splicing: 5 isoforms: O60506-1 O60506-2 O60506-3 O60506-4 O60506-5 (May be due to a competing donor splice site and to an exon inclusion)Explore the universe of human proteins at neXtProt for SYNCRIP: NX_O60506
Post-translational modifications:
Phosphorylated on tyrosine. The membrane-bound form found in microsomes is phosphorylated in vitro by insulin receptortyrosine kinase (INSR). Phosphorylation is inhibited upon binding to RNA, whereas the cytoplasmic form is poorlyphosphorylated (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O60506
SYNCRIP Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (7 alternative transcripts):
NP_001153145.1 NP_001153146.1 NP_001153147.1 NP_001153148.1 NP_001153149.1 NP_001240700.1 NP_006363.4
ENSEMBL proteins: ENSP00000426494 ENSP00000347380 ENSP00000358635 ENSP00000397782
Human Recombinant Protein Products for SYNCRIP:
Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9): About this table
SYNCRIP for ontologies About GeneDecksing
SYNCRIP Antibody Products:
Assay Products for SYNCRIP: |
Protein
Domains /
Families
for SYNCRIP gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SYNCRIP for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O60506ProtoNet protein and cluster: O60506 UniProtKB/Swiss-Prot: HNRPQ_HUMAN, O60506Domain: The domain containing eight Arg-Gly-Gly repeats may be involved in RNA-binding and protein-protein interactionsSimilarity: Contains 3 RRM (RNA recognition motif) domains |
Function
for SYNCRIP gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: HNRPQ_HUMAN, O60506Function: Heterogenous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. Component of theCRD-mediated complex that promotes MYC mRNA stability. Isoform 1, isoform 2 and isoform 3 are associated in vitro withpre-mRNA, splicing intermediates and mature mRNA protein complexes. Isoform 1 binds to apoB mRNA AU-rich sequences.Isoform 1 is part of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of theAPOB mRNA through either by binding to A1CF (APOBEC1 complementation factor), to APOBEC1 or to RNA itself. May beinvolved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmicdeadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant ofinstability (mCRD) domain. Interacts in vitro preferentially with poly(A) and poly(U) RNA sequences. Isoform 3 may beinvolved in cytoplasmic vesicle-based mRNA transport through interaction with synaptotagmins. Component of the GAIT(gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-inducedtranscript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation assembles intothe GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (suchas ceruplasmin) and suppresses their translation; seems not to be essential for GAIT complex function Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
SYNCRIP for ontologies About GeneDecksing
Phenotypes:
4 GenomeRNAi human phenotypes for SYNCRIP:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SYNCRIP (see all 9)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SYNCRIP (see all 6)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 6): SYNCRIP (NM_001159676) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SYNCRIP | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYNCRIP |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYNCRIP |
|
Pathways & Interactions
for SYNCRIP gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Translational Control | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Cell Signaling Technology (CST) Pathway for SYNCRIP
SYNCRIP for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SYNCRIP
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/765 Interacting proteins for SYNCRIP (O605061, 2, 3 ENSP000003586354) via UniProtKB, MINT, STRING, and/or I2D (see all 765)About this table
Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table
SYNCRIP for ontologies About GeneDecksing
|
Drugs & Compounds
for SYNCRIP gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SYNCRIP
Search CenterWatch for drugs/clinical trials and news about SYNCRIP / HNRPQ
|
Transcripts
for SYNCRIP gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SYNCRIP gene (7 alternative transcripts): NM_001159673.1 NM_001159674.1 NM_001159675.1 NM_001159676.1 NM_001159677.1 NM_001253771.1 NM_006372.4 Unigene Cluster for SYNCRIP: Synaptotagmin binding, cytoplasmic RNA interacting protein Hs.571177 [show with all ESTs]Unigene Representative Sequence: NM_0011596774 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000503906 ENST00000355238(uc003pku.3 uc003pkv.3 uc003pkw.3 uc003pkx.3 uc003pky.3)
ENST00000369622(uc003pkz.2 uc003pla.2) ENST00000444272
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SYNCRIP (see all 9)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SYNCRIP (see all 6)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 6): SYNCRIP (NM_001159676) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SYNCRIP | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYNCRIP |
Additional cDNA sequence: AB209098.1 AF037448.1 AF155568.1 AK056188.1 AK222776.1 AK294212.1 AK299796.1 AK313572.1 AY034481.1 AY034482.1 AY034483.1 BC009176.2 BC015575.2 BC021932.1 BC024283.1 BC032643.1 BC040844.1 24/30 DOTS entries (see all 30): DT.100874783 DT.100046070 DT.455852 DT.91776556 DT.100874784 DT.91950888 DT.95264437 DT.86854256 DT.100874788 DT.99982340 DT.100046084 DT.100840959 DT.97860332 DT.121330193 DT.100668409 DT.120798424 DT.91776560 DT.121330146 DT.120834968 DT.121330084 DT.100041401 DT.100733770 DT.100874798 DT.121330247 24/467 AceView cDNA sequences (see all 467): NM_006372 CA447046 CA413299 AK056188 AI581394 CB130920 CR611039 AA032165 BC005110 BM455117 BF732338 AA363926 BM751035 BU164891 AI285030 BQ945048 BI438839 AA431154 AA625241 CD358572 CF129670 CD652059 AA987698 BE407142
GeneLoc Exon Structure
5/12 Alternative Splicing Database (ASD) splice patterns (SP) for SYNCRIP (see all 12) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | |
| SP3: | | | | | | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14a | · | 14b |
|---|
|
| SP1: | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SYNCRIP
|
Expression
for SYNCRIP gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SYNCRIP expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCAAACAATC
About this image
See SYNCRIP Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SYNCRIP
SOURCE GeneReport for Unigene cluster: Hs.571177
UniProtKB/Swiss-Prot: HNRPQ_HUMAN, O60506Tissue specificity: Ubiquitously expressed. Detected in heart, brain, pancreas, placenta, spleen, lung, liver, skeletalmuscle, kidney, thymus, prostate, uterus, small intestine, colon, peripheral blood and testis
SABiosciences Custom PCR Arrays for SYNCRIP
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SYNCRIP
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SYNCRIP | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SYNCRIP | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SYNCRIP | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYNCRIP |
Orthologs
for SYNCRIP gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for SYNCRIP gene from 8/23 species (see all 23) About this table
ENSEMBL Gene Tree for SYNCRIP (if available)
TreeFam Gene Tree for SYNCRIP (if available) |
Paralogs
for SYNCRIP gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SYNCRIP gene
- RBM472 DND12 RBM462 A1CF2 HNRNPR2
8 SIMAP similar genes for SYNCRIP using alignment to 5 protein entries: HNRPQ_HUMAN (see all proteins):DKFZp686A13234 HNRPR DKFZp686O0665 HNRNPR RBM46 A1CF
RBM47 TIAL1
SYNCRIP for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for SYNCRIP
PGOHUM00000247585
|
Genomic Variants
for SYNCRIP gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SYNCRIP (86267696 - 86353510 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SYNCRIP: --
Human Gene Mutation Database (HGMD): SYNCRIP
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SYNCRIP |
|
Disorders
/ Diseases
for SYNCRIP gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SYNCRIP for disorders About GeneDecksing
9  diseases for SYNCRIP: About MalaCardsspinal muscular atrophy muscular atrophy neuronitis hepatitis c
hepatocellular carcinoma colon cancer hepatitis carcinoma
prostatitis
Export disorders for SYNCRIP gene to outside databases
|
Publications
for SYNCRIP gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SYNCRIP gene, integrated from 9 sources (see all 76):
(articles sorted by number of sources associating them with SYNCRIP) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Two-hybrid cloning identifies an RNA-binding protein, GRY-RBP, as a component of apobec-1 editosome. (PubMed id 11352648)1, 2, 3, 9 Lau P.P.... Chan L. (2001)
- A novel heterogeneous nuclear ribonucleoprotein-like protein interacts with NS1 of the minute virus of mice. (PubMed id 9847309)1, 2, 3, 9 Harris C.E.... Astell C.R. (1999)
- SMN interacts with a novel family of hnRNP and spliceosomal proteins. (PubMed id 11574476)1, 2, 9 Mourelatos Z.... Dreyfuss G. (2001)
- Control of c-myc mRNA stability by IGF2BP1-associated cytoplasmic RNPs. (PubMed id 19029303)1, 2 Weidensdorfer D....HA1ttelmaier S. (2009)
- Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry. (PubMed id 17370265)1, 2 Denis N.J.... Figeys D. (2007)
- Molecular composition of IMP1 ribonucleoprotein granules. (PubMed id 17289661)1, 2 Joeson L.... Nielsen F.C. (2007)
- Noncanonical function of glutamyl-prolyl-tRNA synthetase: gene-specific silencing of translation. (PubMed id 15479637)1, 2 Sampath P....Fox P.L. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Signaling initiated by overexpression of the fibroblast growth factor receptor-1 investigated by mass spectrometry. (PubMed id 12601080)1, 2 Hinsby A.M.... Mann M. (2003)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
|
External Searches for SYNCRIP gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SYNCRIP gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SYNCRIP gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SYNCRIP gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SYNCRIP | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SYNCRIP gene:
Search GeneIP for patents involving SYNCRIP
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SYNCRIP gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SYNCRIP | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SYNCRIP | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SYNCRIP | | | OriGene Protein Over-expression Lysate for SYNCRIP | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SYNCRIP | | OriGene 3'-UTR Clone for SYNCRIP | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SYNCRIP | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SYNCRIP | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SYNCRIP | | OriGene Custom Protein Services for SYNCRIP | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SYNCRIP | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SYNCRIP | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SYNCRIP | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SYNCRIP | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SYNCRIP | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SYNCRIP |
| |
 |  |  |  | |
| | Antibodies & Assays for SYNCRIP (NSAP1) |
| | | | Search Tocris compounds for SYNCRIP |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | SYNCRIP Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYNCRIP |
|  |  |  |  | | | | ThermoFisher Antibodies for SYNCRIP |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYNCRIP |
| |  | |
|
|
|
