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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SYNC Gene

protein-coding GIFtS: 46
GCID: GC01M033145

syncoilin, intermediate filament protein

(Previous names: syncoilin, intermediate filament 1 )
(Previous symbol: SYNC1)

Explore 8 diseases affiliated with
SYNC via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Syncoilin, Intermediate Filament Protein¹ ²		Intermediate Filament Protein Syncoilin²
SYNC1¹ ² ³ ⁵		Syncoilin¹
SYNCOILIN¹ ²		Syncoilin-1³
Syncoilin, Intermediate Filament 1¹ ²		Syncoilin-1³
Syncoilin Intermediate Filament 1² ³

External Ids:	HGNC: 28897¹	Entrez Gene: 81493²	Ensembl: ENSG00000162520⁷	OMIM: 611750⁵	UniProtKB: Q9H7C4³

Export aliases for SYNC gene to outside databases

Previous GC identifers: GC01M032919 GC01M031260

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SYNC:

This gene encodes a member of the intermediate filament family which contains an N-terminal head domain, followed by a

central coiled-coil region and a short C-terminal tail. The protein is highly expressed in skeletal and cardiac

muscle. The protein links the dystrophin associated protein complex (DAPC) to desmin filaments in muscle and may have

a structural role in striated muscle. Multiple transcript variants encoding different isoforms have been found for

this gene. (provided by RefSeq, Jun 2009)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_032977.9

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SYNC gene promoter:
NF-1 AP-4 C/EBPalpha Evi-1 E47 CHOP-10 ARP-1 Pax-4a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SYNC promoter sequence

Search SABiosciences Chromatin IP Primers for SYNC

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SYNC

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p35.1 Ensembl cytogenetic band: 1p35.1 HGNC cytogenetic band: 1p35.1

SYNC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SYNC gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M033145: view genomic region (about GC identifiers)

Start:	33,145,507 bp from pter	End:	33,169,197 bp from pter
Size:	23,691 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SYNCI_HUMAN, Q9H7C4 (See protein sequence)

Recommended Name: Syncoilin

Size: 482 amino acids; 55299 Da

Subunit: Interacts with DES and DTNA (By similarity)

Subcellular location: Cytoplasm, perinuclear region (By similarity). Note=In skeletal muscle, colocalizes with DES and

DTNA, and is localized at the myotendinous and neuromuscular junctions, sarcolemma and Z-lines. In myotubes, detected

in a punctate cytoplasmic pattern (By similarity)

Sequence caution: Sequence=AAI19701.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Sequence=AAI19702.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB14970.1;

Type=Erroneous initiation; Note=Translation N-terminally extended;

Secondary accessions: B4DNK8 B4DY58 C9IY41

Alternative splicing: 2 isoforms: Q9H7C4-1 Q9H7C4-2

Explore the universe of human proteins at neXtProt for SYNC: NX_Q9H7C4

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9H7C4

SYNC Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001155180.1 NP_110413.2

ENSEMBL proteins:

ENSP00000386439 ENSP00000401975 ENSP00000387594 ENSP00000362583

Human Recombinant Protein Products for SYNC:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: SYNC OriGene Custom Protein Services for SYNC
	GenScript Custom Purified and Recombinant Proteins Services for SYNC
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SYNC

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	--	--
GO:0005829	cytosol	IEA	--
GO:0005882	intermediate filament	IEA	--
GO:0030018	Z disc	IEA	--
GO:0031594	neuromuscular junction	IEA	--

SYNC for ontologies About GeneDecksing

SYNC Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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	GenScript Custom Superior Antibodies Services for SYNC
	Novus Biologicals SYNC Antibody
	Abcam antibodies for SYNC
	Uscn Antibodies for SYNC
	ThermoFisher Antibody for SYNC

Assay Products for SYNC:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for SYNC
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for SYNC

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SYNC for domains About GeneDecksing

2 InterPro domains/families:

IPR001664 IF

IPR016044 F

Graphical View of Domain Structure for InterPro Entry Q9H7C4

ProtoNet protein and cluster: Q9H7C4

UniProtKB/Swiss-Prot: SYNCI_HUMAN, Q9H7C4

Similarity: Belongs to the intermediate filament family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: SYNCI_HUMAN, Q9H7C4

Induction: Up-regulated at the sarcolemma in individuals with various forms of neuromuscular disease

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005198	structural molecule activity	IEA	--
GO:0005515	protein binding	--	--

SYNC for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for SYNC:

Decreased viability with pacli

3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Sync):

cardiovascular system

homeostasis/metabolism

muscle

SYNC for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for SYNC: Sync^tm1.1Ked Sync^tm1Chen

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SYNC

miRNA Products:		OriGene 3'-UTR Clone (see all 2): SYNC Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SYNC
		8/72 QIAGEN miScript miRNA Assays for microRNAs that regulate SYNC (see all 72):
		hsa-miR-520e hsa-miR-520f hsa-miR-578 hsa-miR-519a hsa-miR-3122 hsa-miR-629 hsa-miR-3649 hsa-miR-761

		SwitchGear 3'UTR luciferase reporter plasmid: SYNC 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SYNC (see all 7) OriGene shRNA RFP: SYNC OriGene siRNA: SYNC
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SYNC
		Sirion Biotech Custom design and validation of potent shRNA sequences against SYNC

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for SYNC
			Sirion Biotech Customized adenovirus for overexpression of SYNC Sirion Biotech Customized adenovirus for potent knockdown of SYNC

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SYNC (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SYNC (see all 3) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 6): SYNC (NM_001159676)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SYNC
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYNC

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SYNC
		Search LifeMap BioReagents cell lines for SYNC
		Sirion Biotech Customized stable knockdown cell line services for SYNC Sirion Biotech Customized inducible knockdown cell line services for SYNC Sirion Biotech Customized stable overexpressing cell line services for SYNC Sirion Biotech Customized inducible overexpressing cell line services for SYNC

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYNC

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SYNC

STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

5/14 Interacting proteins for SYNC (Q9H7C4³ ENSP00000386439⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 14)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DES	P17661³, ENSP00000363071⁴	I2D: score=4 STRING: ENSP00000363071
DTNA	Q9Y4J8³, ENSP00000382064⁴	I2D: score=1 STRING: ENSP00000382064
MLST8	Q9BVC4³	I2D: score=1
BTNL10	ENSP00000383732⁴	STRING: ENSP00000383732
HTR6	ENSP00000289753⁴	STRING: ENSP00000289753

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0045103	intermediate filament-based process	IEA	--

SYNC for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

SYNC for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SYNC
1 Novoseek chemical compound relationship for SYNC gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
dapc	93	3	16124004 (2), 15773750 (1)

Search CenterWatch for drugs/clinical trials and news about SYNC / SYNCI

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SYNC gene (2 alternative transcripts):

NM_001161708.1 NM_030786.2

Unigene Cluster for SYNC:

Syncoilin, intermediate filament protein

Hs.712631 [show with all ESTs]

Unigene Representative Sequence: NM_030786

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000409190 ENST00000417633 ENST00000426909 ENST00000373484(uc001bvt.2 uc010ohl.1)

miRNA Products:		OriGene 3'-UTR Clone (see all 2): SYNC Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SYNC
		8/72 QIAGEN miScript miRNA Assays for microRNAs that regulate SYNC (see all 72):
		hsa-miR-520e hsa-miR-520f hsa-miR-578 hsa-miR-519a hsa-miR-3122 hsa-miR-629 hsa-miR-3649 hsa-miR-761

		SwitchGear 3'UTR luciferase reporter plasmid: SYNC 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SYNC (see all 7) OriGene shRNA RFP: SYNC OriGene siRNA: SYNC
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SYNC
		Sirion Biotech Custom design and validation of potent shRNA sequences against SYNC

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SYNC (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SYNC (see all 3) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 6): SYNC (NM_001159676)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SYNC
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYNC

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SYNC Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SYNC
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SYNC
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SYNC

Additional cDNA sequence:

AK024707.1 AK297958.1 AK302275.1 BC119700.1 BC119701.1

15 DOTS entries:

DT.455410 DT.100037462 DT.75124591 DT.100861479 DT.100799516 DT.91970046 DT.121463401 DT.121463449

DT.65288515 DT.97859978 DT.99939607 DT.100861482 DT.121463577 DT.95169497 DT.95125024

12 AceView cDNA sequences:

AK024707 NM_030786 BF196262 CN479602 BF924279 CB051780 AI074110 AA111835

BE938852 BI492943 W24127 AI906308

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SYNC expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGAGTAACA

About this image

SYNC expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 4 LifeMap Cells

Name

Category

PureStem™ progenitor T42 (Embryonic Progenitor Cell)

PureStem™ progenitor E69 (Embryonic Progenitor Cell)

PureStem™ progenitor T36 (Embryonic Progenitor Cell)

ES04(HES-4) (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SYNC Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SYNC

SOURCE GeneReport for Unigene cluster: Hs.712631

SABiosciences Custom PCR Arrays for SYNC

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SYNC Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SYNC
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SYNC
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SYNC

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYNC

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for SYNC gene from 4/9 species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Sync^{1 , 5}	syncoilin^{1, 5}	80.98(n)¹ 79.27(a)¹		4 (63.26 cM)⁵ 68828¹ NM_023485.3¹ NP_075974.3¹ 129287617⁵
chicken (Gallus gallus)	Aves	SYNC¹	syncoilin, intermediate filament protein	65.71(n) 60.58(a)		419664 XM_417811.2 XP_417811.2
lizard (Anolis carolinensis)	Reptilia	SYNC⁶	--	57(a)	1 ↔ 1	GL344283.1(37736-46293)
zebrafish (Danio rerio)	Actinopterygii	sync¹	syncoilin, intermediate filament protein	47.57(n) 32.82(a)		100034635 XM_003200615.1 XP_003200663.1

ENSEMBL Gene Tree for SYNC (if available)
TreeFam Gene Tree for SYNC (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs79557632^1,2	C	--	31265140(+)	`TCTTAA/CCTGCC`	4	V L	mis¹		0	--	--	--	--
rs56077550^1,2	C,F	--	31269048(+)	`ACTCTC/AAAGCT`	2	--	int¹		3		WA CSA	122
rs6673774^1,2	C,F,H	--	31269228(+)	`GCTGGG/AGTAGT`	2	--	int¹		4		NS EA	418
rs2625022^1,2		--	31269980(+)	`tcgatC/Attttg`	2	--	int¹		1		CSA	2
rs75544685^1,2	F	--	31270322(+)	`CACACA/GTACTA`	2	--	int¹		1		WA	118
rs11320061^1,2	C	--	31270883(+)	`ATAGC-/AACAAG`	2	--	int¹		0	--	--	--	--
rs71855250^1,2	C	--	31271489(+)	`AAAGT-/AGAG AGGCA`	2	--	int¹		0	--	--	--	--
rs113218310^1,2		--	31271756(+)	`AAACAA/GTTGGC`	2	--	int¹		2		CSA WA	119
rs424014^1,2		--	31271875(+)	`ctctaA/Ctaaaa`	2	--	int¹		0	--	--	--	--
rs112840799^1,2		--	31271906(+)	`ATGGTG/AGCATG`	2	--	int¹		1		CSA	2

HapMap Linkage Disequilibrium report for SYNC (33145507 - 33169197 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SYNC: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SYNC

DNA2.0 Custom Variant and Variant Library Synthesis for SYNC

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SYNC for disorders           About GeneDecksing

OMIM gene information: 611750    OMIM disorders: --

8 diseases for SYNC:    About MalaCards

charcot-marie-tooth neuropathy muscular dystrophy myofibrillar myopathy neuromuscular disease

myopathy neuropathy neuronitis intermediate charcot-marie-tooth neuropathy

5 Novoseek disease relationships for SYNC gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
desmin-related myopathy	92.7	2	11694502 (1), 12467731 (1)
muscular dystrophies	78.2	3	11694502 (1), 18810324 (1), 16124004 (1)
neuromuscular diseases	72.5	3	16124004 (2), 18367591 (1)
muscular dystrophy becker	68.2	1	16124004 (1)
myopathy	61	1	18367591 (1)

Export disorders for SYNC gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SYNC gene, integrated from 9 sources (see all 20):
(articles sorted by number of sources associating them with SYNC)

Utopia: connect your pdf to the dynamic
world of online information

Syncoilin upregulation in muscle of patients with neuromuscular disease. (PubMed id 16124004)^{1, 2, 9} Brown S.C.... Muntoni F. (2005)
Syncoilin, a novel member of the intermediate filament superfamily that interacts with alpha-dystrobrevin in skeletal muscle. (PubMed id 11053421)^{1, 3} Newey S.E....Blake D.J. (2001)
Association of syncoilin and desmin: linking intermediate filament proteins to the dystrophin-associated protein complex. (PubMed id 11694502)^{1, 9} Poon E....Davies K.E. (2002)
Dysbindin, syncoilin, and beta-synemin mRNA levels in dystrophic muscles. (PubMed id 20199207)^{1, 9} Wakayama Y....Masaki H. (2010)
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)² Olsen J.V....Mann M. (2010)
Syncoilin modulates peripherin filament networks and is necessary for large-calibre motor neurons. (PubMed id 20587592)¹ Clarke W.T....Davies K.E. (2010)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)² Gregory S.G.... Bentley D.R. (2006)
Disrupted function and axonal distribution of mutant tyrosyl-tRNA synthetase in dominant intermediate Charcot-Marie-Tooth neuropathy. (PubMed id 16429158)¹ Jordanova A....Timmerman V. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)² Ota T.... Sugano S. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 81493	HGNC: 28897	AceView: SYNCOILIN	Ensembl:ENSG00000162520	euGenes: HUgn81493
ECgene: SYNC	H-InvDB: SYNC

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SYNC	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SYNC gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for SYNC gene:
Search GeneIP for patents involving SYNC

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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SYNC Gene

syncoilin, intermediate filament protein

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SYNC Gene

syncoilin, intermediate filament protein

Aliasesfor SYNC gene

Summariesfor SYNC gene

Genomic Viewsfor SYNC gene

Proteinsfor SYNC gene

Protein Domains /Familiesfor SYNC gene

Functionfor SYNC gene

Pathways & Interactionsfor SYNC gene

Drugs & Compoundsfor SYNC gene

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Expression for SYNC gene

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for SYNC gene

Genomic Views
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for SYNC gene

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for SYNC gene

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for SYNC gene

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for SYNC gene

Transcripts
for SYNC gene

Expression
for SYNC gene

Orthologs
for SYNC gene

Paralogs
for SYNC gene

Genomic Variants
for SYNC gene

Disorders / Diseases
for SYNC gene

Publications
for SYNC gene

Intellectual Property
for SYNC gene

Products
for SYNC gene