Aliases for SYNC Gene
External Ids for SYNC Gene
Previous HGNC Symbols for SYNC Gene
Previous GeneCards Identifiers for SYNC Gene
This gene encodes a member of the intermediate filament family which contains an N-terminal head domain, followed by a central coiled-coil region and a short C-terminal tail. The protein is highly expressed in skeletal and cardiac muscle. The protein links the dystrophin associated protein complex (DAPC) to desmin filaments in muscle and may have a structural role in striated muscle. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]
GeneCards Summary for SYNC Gene
SYNC (Syncoilin, Intermediate Filament Protein) is a Protein Coding gene. Diseases associated with SYNC include Neuromuscular Disease and Intermediate Charcot-Marie-Tooth Neuropathy. GO annotations related to this gene include structural molecule activity.
UniProtKB/Swiss-Prot for SYNC Gene
Atypical type III intermediate filament (IF) protein that may play a supportive role in the efficient coupling of mechanical stress between the myofibril and fiber exterior. May facilitate lateral force transmission during skeletal muscle contraction. Does not form homofilaments nor heterofilaments with other IF proteins.