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SYNC Gene

protein-coding   GIFtS: 44
GCID: GC01M033145

Syncoilin, Intermediate Filament Protein

(Previous names: syncoilin, intermediate filament 1)
(Previous symbol: SYNC1)
  See SYNC-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Syncoilin, Intermediate Filament Protein1 2     Intermediate Filament Protein Syncoilin2
SYNC11 2 3 5     syncoilin2
Syncoilin, Intermediate Filament 11 2     syncoilin-12
Syncoilin Intermediate Filament 12 3     Syncoilin-13
SYNCOILIN2     

External Ids:    HGNC: 288971   Entrez Gene: 814932   Ensembl: ENSG000001625207   OMIM: 6117505   UniProtKB: Q9H7C43   

Export aliases for SYNC gene to outside databases

Previous GC identifers: GC01M032919 GC01M031260


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SYNC Gene:
This gene encodes a member of the intermediate filament family which contains an N-terminal head domain, followed
by a central coiled-coil region and a short C-terminal tail. The protein is highly expressed in skeletal and
cardiac muscle. The protein links the dystrophin associated protein complex (DAPC) to desmin filaments in muscle
and may have a structural role in striated muscle. Multiple transcript variants encoding different isoforms have
been found for this gene. (provided by RefSeq, Jun 2009)

GeneCards Summary for SYNC Gene:
SYNC (syncoilin, intermediate filament protein) is a protein-coding gene. Diseases associated with SYNC include intermediate charcot-marie-tooth neuropathy. GO annotations related to this gene include structural molecule activity.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the SYNC gene promoter:
         NF-1   AP-4   C/EBPalpha   Evi-1   E47   CHOP-10   ARP-1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSYNC promoter sequence
   Search Chromatin IP Primers for SYNC

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SYNC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p35.1   Ensembl cytogenetic band:  1p35.1   HGNC cytogenetic band: 1p35.1

SYNC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SYNC gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M033145:  view genomic region     (about GC identifiers)

Start:
33,145,507 bp from pter      End:
33,169,197 bp from pter
Size:
23,691 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SYNCI_HUMAN, Q9H7C4 (See protein sequence)
Recommended Name: Syncoilin  
Size: 482 amino acids; 55299 Da
Subunit: Interacts with DES and DTNA (By similarity)
Sequence caution: Sequence=AAI19701.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAI19702.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB14970.1;
Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B4DNK8 B4DY58 C9IY41
Alternative splicing: 2 isoforms:  Q9H7C4-1   Q9H7C4-2   

Explore the universe of human proteins at neXtProt for SYNC: NX_Q9H7C4

Explore proteomics data for SYNC at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SYNC Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001155180.1  NP_110413.2  

    ENSEMBL proteins: 
     ENSP00000386439   ENSP00000401975   ENSP00000387594   ENSP00000362583  

    SYNC Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for SYNC
    OriGene Protein Over-expression Lysate for SYNC
    OriGene Custom MassSpec
    OriGene Custom Protein Services for SYNC
    GenScript Custom Purified and Recombinant Proteins Services for SYNC
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SYNC

     
    Search eBioscience for Proteins for SYNC 

     
    antibodies-online proteins for SYNC (2 products) 

     
    antibodies-online peptides for SYNC

    SYNC Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for SYNC
    OriGene Custom Antibody Services for SYNC
    Novus Biologicals SYNC Antibody
    Abcam antibodies for SYNC
    Cloud-Clone Corp. Antibodies for SYNC
    ThermoFisher Antibody for SYNC
    antibodies-online antibodies for SYNC (23 products) 

    SYNC Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SYNC
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SYNC
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SYNC
    Cloud-Clone Corp. CLIAs for SYNC
    Search eBioscience for ELISAs for SYNC 
    antibodies-online kits for SYNC (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IFF3: Intermediate filaments type III

    2 InterPro protein domains:
     IPR027702 Syncoilin
     IPR001664 IF

    Graphical View of Domain Structure for InterPro Entry Q9H7C4

    ProtoNet protein and cluster: Q9H7C4

    UniProtKB/Swiss-Prot: SYNCI_HUMAN, Q9H7C4
    Similarity: Belongs to the intermediate filament family


    Find genes that share domains with SYNC           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SYNCI_HUMAN, Q9H7C4
    Induction: Up-regulated at the sarcolemma in individuals with various forms of neuromuscular disease

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity IEA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with SYNC           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SYNC:
     Decreased viability with pacli 

         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Sync):
     cardiovascular system  homeostasis/metabolism  muscle 

    Find genes that share phenotypes with SYNC           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for SYNC: Synctm1.1Ked Synctm1Chen

       genOway: Develop your customized and physiologically relevant rodent model for SYNC

    miRNA
    Products:
        
    miRTarBase miRNAs that target SYNC:
    hsa-mir-124-3p (MIRT022350)

    Block miRNA regulation of human, mouse, rat SYNC using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SYNC (see all 72):
    hsa-miR-520e hsa-miR-520f hsa-miR-578 hsa-miR-519a hsa-miR-3122 hsa-miR-629 hsa-miR-3649 hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmidSYNC 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SYNC
    Predesigned siRNA for gene silencing in human, mouse, rat SYNC

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SYNC

    Clone
    Products:
         
    OriGene clones in human, mouse for SYNC (see all 12)
    OriGene ORF clones in mouse, rat for SYNC
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 6): SYNC (NM_001159676)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SYNC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYNC

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SYNC
    Browse ESI BIO Cell Lines and PureStem Progenitors for SYNC 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYNC


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SYNCI_HUMAN, Q9H7C4: Cytoplasm, perinuclear region (By similarity). Note=In skeletal muscle, colocalizes with DES
    and DTNA, and is localized at the myotendinous and neuromuscular junctions, sarcolemma and Z-lines. In myotubes,
    detected in a punctate cytoplasmic pattern (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton3
    nucleus3
    cytosol2
    plasma membrane2
    extracellular1
    golgi apparatus1
    lysosome1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005829cytosol IEA--
    GO:0005882intermediate filament IEA--
    GO:0030018Z disc IEA--
    GO:0031594neuromuscular junction IEA--

    Find genes that share ontologies with SYNC           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SYNC
    Interactions:

        Search GeneGlobe Interaction Network for SYNC

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    Selected Interacting proteins for SYNC (Q9H7C43 ENSP000003864394) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DESP176613, ENSP000003630714I2D: score=4 STRING: ENSP00000363071
    DTNAQ9Y4J83, ENSP000003820644I2D: score=1 STRING: ENSP00000382064
    MLST8Q9BVC43I2D: score=1 
    ENSG00000206279ENSP000003822814STRING: ENSP00000382281
    ENSG00000225073ENSP000004003264STRING: ENSP00000400326
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0045103intermediate filament-based process IEA--

    Find genes that share ontologies with SYNC           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SYNC (SYNCI)

    1 Novoseek inferred chemical compound relationship for SYNC gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dapc 93 3 16124004 (2), 15773750 (1)



    Find genes that share compounds with SYNC           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SYNC gene (2 alternative transcripts): 
    NM_001161708.1  NM_030786.2  

    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000409190 ENST00000417633 ENST00000426909 ENST00000373484(uc001bvt.2 uc010ohl.1)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SYNC using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SYNC (see all 72):
    hsa-miR-520e hsa-miR-520f hsa-miR-578 hsa-miR-519a hsa-miR-3122 hsa-miR-629 hsa-miR-3649 hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmidSYNC 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SYNC
    Predesigned siRNA for gene silencing in human, mouse, rat SYNC
    Clone
    Products:
         
    OriGene clones in human, mouse for SYNC (see all 12)
    OriGene ORF clones in mouse, rat for SYNC
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 6): SYNC (NM_001159676)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SYNC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYNC
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SYNC
    OriGene qSTAR qPCR primer pairs in human, mouse for SYNC
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SYNC
      QuantiTect SYBR Green Assays in human, mouse, rat SYNC
      QuantiFast Probe-based Assays in human, mouse, rat SYNC

    12 AceView cDNA sequences:

    CN479602 NM_030786 AK024707 BF196262 AI074110 CB051780 BF924279 AA111835 
    BE938852 BI492943 W24127 AI906308 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SYNC expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGAGTAACA
    SYNC Expression
    About this image


    SYNC expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Fibroblasts
             Detroit 551
     
     Epidermis (Integumentary System)
             Detroit 551
    SYNC Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SYNC Protein Expression
        Custom PCR Arrays for SYNC
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SYNC
    OriGene qSTAR qPCR primer pairs in human, mouse for SYNC
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SYNC
    QuantiTect SYBR Green Assays in human, mouse, rat SYNC
    QuantiFast Probe-based Assays in human, mouse, rat SYNC
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYNC

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SYNC gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sync1 , 5 syncoilin1, 5 81.17(n)1
    79.1(a)1
      4 (63.26 cM)5
    688281  NM_023485.31  NP_075974.31 
     1292876175 
    chicken
    (Gallus gallus)
    Aves SYNC6
    syncoilin, intermediate filament protein
    58(a)
    1 ↔ 1
    23(5187126-5190581)
    lizard
    (Anolis carolinensis)
    Reptilia SYNC6
    syncoilin, intermediate filament protein
    57(a)
    1 ↔ 1
    GL344283.1(26799-46305)
    zebrafish
    (Danio rerio)
    Actinopterygii sync1 syncoilin, intermediate filament protein 48.4(n)
    34.06(a)
      100034635  XM_005159642.1  XP_005159699.1 


    ENSEMBL Gene Tree for SYNC (if available)
    TreeFam Gene Tree for SYNC (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SYNC (see all 564)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1837174781,2
    --31279197(+) CAGGCA/GTGGTG 2 -- int10--------
    rs1880434651,2
    --31279205(+) GTGGCA/GGGCAC 2 -- int10--------
    rs6571291,2
    C,F--31279760(-) attagC/Tgggtg 2 -- int13Minor allele frequency- T:0.04NA CSA WA 122
    rs717514761,2
    C--33148045(+) TAAAA-/AAAAT/
    AAATG
    /TG
    AAATA
    2 -- int11CSA 2
    rs57733801,2
    C--33148362(+) CGAGACT/-CTGTC 2 -- int11Minor allele frequency- -:0.00CSA 2
    rs113834711,2
    C--33152962(+) ATCTC-/AAAAAA 2 -- int1 trp30--------
    rs612205051,2
    C--33152963(+) AAAAAA/-CCATA 2 -- int11Minor allele frequency- -:0.00NA 2
    rs1127247441,2
    C--33153271(+) GTCTC-/AAAAAA 2 -- int11Minor allele frequency- A:0.50CSA 2
    rs584205071,2
    C--33153272(+) AAAAAA/-GAAAA 2 -- int11Minor allele frequency- -:0.00NA 2
    rs26250221,2
    C,F--33154765(+) tcgatC/Attttg 2 -- int11Minor allele frequency- A:0.50CSA 2

    HapMap Linkage Disequilibrium report for SYNC (33145507 - 33169197 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for SYNC:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2661423CNV Deletion23128226
    esv2746530CNV Deletion23290073
    esv2746541CNV Deletion23290073
    nsv509158CNV Insertion20534489
    nsv461039CNV Loss19166990
    nsv519188CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SYNC
    DNA2.0 Custom Variant and Variant Library Synthesis for SYNC

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611750    OMIM disorders: --

    1 disease for SYNC:    
    About MalaCards
    intermediate charcot-marie-tooth neuropathy


    Find genes that share disorders with SYNC           About GenesLikeMe

    5 Novoseek inferred disease relationships for SYNC gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    desmin-related myopathy 92.7 2 11694502 (1), 12467731 (1)
    muscular dystrophies 78.2 3 11694502 (1), 18810324 (1), 16124004 (1)
    neuromuscular diseases 72.5 3 16124004 (2), 18367591 (1)
    muscular dystrophy becker 68.2 1 16124004 (1)
    myopathy 61 1 18367591 (1)


    Export disorders for SYNC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SYNC gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with SYNC)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Syncoilin upregulation in muscle of patients with neuromuscular disease. (PubMed id 16124004)1, 2, 9 Brown S.C.... Muntoni F. (Muscle Nerve 2005)
    2. Syncoilin, a novel member of the intermediate filament superfamily that interacts with alpha-dystrobrevin in skeletal muscle. (PubMed id 11053421)1, 3 Newey S.E....Blake D.J. (J. Biol. Chem. 2001)
    3. Association of syncoilin and desmin: linking intermediate filament proteins to the dystrophin-associated protein complex. (PubMed id 11694502)1, 9 Poon E....Davies K.E. (J. Biol. Chem. 2002)
    4. Dysbindin, syncoilin, and beta-synemin mRNA levels in dystrophic muscles. (PubMed id 20199207)1, 9 Wakayama Y....Masaki H. (Int. J. Neurosci. 2010)
    5. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)
    6. Syncoilin modulates peripherin filament networks and is necessary for large-calibre motor neurons. (PubMed id 20587592)1 Clarke W.T....Davies K.E. (J. Cell. Sci. 2010)
    7. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (Nature 2006)
    8. Disrupted function and axonal distribution of mutant tyrosyl-tRNA synthetase in dominant intermediate Charcot-Marie-Tooth neuropathy. (PubMed id 16429158)1 Jordanova A....Timmerman V. (Nat. Genet. 2006)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 81493 HGNC: 28897 AceView: SYNCOILIN Ensembl:ENSG00000162520 euGenes: HUgn81493
    ECgene: SYNC H-InvDB: SYNC

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SYNC Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SYNC gene:
    Search GeneIP for patents involving SYNC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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