Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SYN3 Gene

Aliases for SYN3 Gene

  • Synapsin III 2 3 4 5

External Ids for SYN3 Gene

Previous GeneCards Identifiers for SYN3 Gene

  • GC22M029604
  • GC22M031233
  • GC22M032908
  • GC22M015865

Summaries for SYN3 Gene

Entrez Gene Summary for SYN3 Gene

  • This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. The protein encoded by this gene shares the synapsin family domain model, with domains A, C, and E exhibiting the highest degree of conservation. The protein contains a unique domain J, located between domains C and E. Based on this gene's localization to 22q12.3, a possible schizophrenia susceptibility locus, and the established neurobiological roles of the synapsins, this family member may represent a candidate gene for schizophrenia. The TIMP3 gene is located within an intron of this gene and is transcribed in the opposite direction. Alternative splicing of this gene results in multiple splice variants that encode different isoforms. [provided by RefSeq, Oct 2008]

GeneCards Summary for SYN3 Gene

SYN3 (Synapsin III) is a Protein Coding gene. Diseases associated with SYN3 include vulvitis and vulvar disease. Among its related pathways are Neurotransmitter Release Cycle and Transmission across Chemical Synapses. An important paralog of this gene is SYN2.

UniProtKB/Swiss-Prot for SYN3 Gene

  • May be involved in the regulation of neurotransmitter release and synaptogenesis.

Gene Wiki entry for SYN3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYN3 Gene

Genomics for SYN3 Gene

Regulatory Elements for SYN3 Gene

Promoters for SYN3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SYN3 on UCSC Golden Path with GeneCards custom track

Genomic Location for SYN3 Gene

Chromosome:
22
Start:
32,508,022 bp from pter
End:
33,058,391 bp from pter
Size:
550,370 bases
Orientation:
Minus strand

Genomic View for SYN3 Gene

Genes around SYN3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SYN3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SYN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYN3 Gene

Proteins for SYN3 Gene

  • Protein details for SYN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14994-SYN3_HUMAN
    Recommended name:
    Synapsin-3
    Protein Accession:
    O14994
    Secondary Accessions:
    • B1B1F9

    Protein attributes for SYN3 Gene

    Size:
    580 amino acids
    Molecular mass:
    63303 Da
    Quaternary structure:
    • Interacts with CAPON.
    Miscellaneous:
    • Regulated by calcium. Calcium inhibits ATP binding to the C-domain.

    Three dimensional structures from OCA and Proteopedia for SYN3 Gene

neXtProt entry for SYN3 Gene

Proteomics data for SYN3 Gene at MOPED

Post-translational modifications for SYN3 Gene

  • Phosphorylation at Ser-9 dissociates synapsins from synaptic vesicles.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SYN3 Gene

Antibody Products

No data available for DME Specific Peptides for SYN3 Gene

Domains & Families for SYN3 Gene

Graphical View of Domain Structure for InterPro Entry

O14994

UniProtKB/Swiss-Prot:

SYN3_HUMAN :
  • The A region binds phospholipids with a preference for negatively charged species.
  • Belongs to the synapsin family.
Domain:
  • The A region binds phospholipids with a preference for negatively charged species.
Family:
  • Belongs to the synapsin family.
genes like me logo Genes that share domains with SYN3: view

No data available for Gene Families for SYN3 Gene

Function for SYN3 Gene

Molecular function for SYN3 Gene

GENATLAS Biochemistry:
synapsin IIIa,synaptic vesicle-associated phosphoprotein,involved in the regulation of neurotransmitter release,synaptogenesis and synaptic plasticity,with six transcripts (SYN3A to SYN3F),SYN3A,3B,3C deleted in fetal and adult brain,SYN30 only in fetal CNS,SYN3E and 3F non neuronal
UniProtKB/Swiss-Prot Function:
May be involved in the regulation of neurotransmitter release and synaptogenesis.

Gene Ontology (GO) - Molecular Function for SYN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
genes like me logo Genes that share ontologies with SYN3: view
genes like me logo Genes that share phenotypes with SYN3: view

Animal Models for SYN3 Gene

MGI Knock Outs for SYN3:

Animal Model Products

miRNA for SYN3 Gene

miRTarBase miRNAs that target SYN3

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SYN3 Gene

Localization for SYN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYN3 Gene

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Peripheral membrane protein localized to the cytoplasmic surface of synaptic vesicles.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SYN3 Gene COMPARTMENTS Subcellular localization image for SYN3 gene
Compartment Confidence
cytosol 3
nucleus 2
cytoskeleton 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SYN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030054 cell junction IEA --
GO:0030672 synaptic vesicle membrane IEA --
GO:0045202 synapse IEA --
genes like me logo Genes that share ontologies with SYN3: view

Pathways & Interactions for SYN3 Gene

genes like me logo Genes that share pathways with SYN3: view

SIGNOR curated interactions for SYN3 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for SYN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007269 neurotransmitter secretion IEA --
GO:0032228 regulation of synaptic transmission, GABAergic TAS 15217342
genes like me logo Genes that share ontologies with SYN3: view

Drugs & Compounds for SYN3 Gene

(1) Drugs for SYN3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with SYN3: view

Transcripts for SYN3 Gene

Unigene Clusters for SYN3 Gene

Synapsin III:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SYN3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b
SP1: - -
SP2: - -
SP3:

Relevant External Links for SYN3 Gene

GeneLoc Exon Structure for
SYN3
ECgene alternative splicing isoforms for
SYN3

Expression for SYN3 Gene

mRNA expression in normal human tissues for SYN3 Gene

mRNA differential expression in normal tissues according to GTEx for SYN3 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x5.9), Brain - Cortex (x4.8), and Brain - Anterior cingulate cortex (BA24) (x4.5).

Protein differential expression in normal tissues from HIPED for SYN3 Gene

This gene is overexpressed in Frontal cortex (31.7), Brain (25.9), and Fetal Brain (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SYN3 Gene



SOURCE GeneReport for Unigene cluster for SYN3 Gene Hs.608750

mRNA Expression by UniProt/SwissProt for SYN3 Gene

O14994-SYN3_HUMAN
Tissue specificity: Neuron specific. Detected predominantly in brain.
genes like me logo Genes that share expression patterns with SYN3: view

Protein tissue co-expression partners for SYN3 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for SYN3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SYN3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SYN3 35
  • 99.37 (n)
  • 99.48 (a)
cow
(Bos Taurus)
Mammalia SYN3 35
  • 90.95 (n)
  • 94.46 (a)
SYN3 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 84 (a)
OneToMany
-- 36
  • 93 (a)
OneToMany
SYN3 35
  • 90.2 (n)
  • 94.12 (a)
mouse
(Mus musculus)
Mammalia Syn3 16
Syn3 36
  • 92 (a)
OneToOne
Syn3 35
  • 87.85 (n)
  • 92.4 (a)
oppossum
(Monodelphis domestica)
Mammalia SYN3 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 64 (a)
OneToMany
-- 36
  • 62 (a)
OneToMany
-- 36
  • 73 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Syn3 35
  • 87.33 (n)
  • 92.23 (a)
chicken
(Gallus gallus)
Aves SYN3 35
  • 76.42 (n)
  • 79.62 (a)
SYN3 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SYN3 36
  • 76 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia syn3-A 35
tropical clawed frog
(Silurana tropicalis)
Amphibia syn3 35
  • 70.27 (n)
  • 72.08 (a)
zebrafish
(Danio rerio)
Actinopterygii SYN3 36
  • 32 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003318 35
fruit fly
(Drosophila melanogaster)
Insecta Syn 35
  • 54.18 (n)
  • 46.37 (a)
Syn 37
  • 43 (a)
Syn 36
  • 33 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea snn-1 35
  • 46.46 (n)
  • 34.29 (a)
snn-1 36
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 65 (a)
ManyToMany
-- 36
  • 46 (a)
ManyToMany
Species with no ortholog for SYN3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SYN3 Gene

ENSEMBL:
Gene Tree for SYN3 (if available)
TreeFam:
Gene Tree for SYN3 (if available)

Paralogs for SYN3 Gene

Paralogs for SYN3 Gene

(3) SIMAP similar genes for SYN3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SYN3: view

Variants for SYN3 Gene

Sequence variations from dbSNP and Humsavar for SYN3 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs5998526 - 32,518,244(+) GGGGG(C/T)TCAGG intron-variant, nc-transcript-variant, reference, missense, utr-variant-3-prime
rs4447 -- 32,879,153(-) CAGCT(A/G)CAGAG intron-variant
rs4450 -- 32,882,917(+) CAACC(A/T)GCTCC intron-variant
rs4451 -- 32,886,705(+) ccttg(C/G)ccctg intron-variant
rs133922 -- 32,988,850(+) AGAGA(A/G)ATGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SYN3 Gene

Variant ID Type Subtype PubMed ID
nsv914981 CNV Loss 21882294
esv23339 CNV Gain 19812545
esv2724149 CNV Deletion 23290073
esv2724150 CNV Deletion 23290073
esv2529621 CNV Insertion 19546169
esv2724152 CNV Deletion 23290073
esv2666744 CNV Deletion 23128226
esv2724153 CNV Deletion 23290073
esv2742642 CNV Deletion 23290073
esv2724154 CNV Deletion 23290073
esv1328555 CNV Insertion 17803354
esv1395557 CNV Insertion 17803354
nsv459875 CNV Gain 19166990
nsv191249 CNV Insertion 16902084
esv1085289 CNV Insertion 17803354
nsv3599 CNV Loss 18451855
esv2638943 CNV Deletion 19546169
dgv20e194 CNV Deletion 18987734
esv3917 CNV Deletion 18987735
nsv191235 CNV Loss 16902084
esv2724155 CNV Deletion 23290073
esv998207 CNV Deletion 20482838
esv2476031 CNV Deletion 19546169
esv1664547 CNV Deletion 17803354
esv6171 CNV Loss 19470904
nsv3600 CNV Insertion 18451855
nsv507934 CNV Insertion 20534489

Variation tolerance for SYN3 Gene

Residual Variation Intolerance Score: 45.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.61; 72.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SYN3 Gene

HapMap Linkage Disequilibrium report
SYN3
Human Gene Mutation Database (HGMD)
SYN3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SYN3 Gene

Disorders for SYN3 Gene

MalaCards: The human disease database

(3) MalaCards diseases for SYN3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
vulvitis
vulvar disease
  • vulvar diseases
schizophrenia
  • schizophrenia 12
- elite association - COSMIC cancer census association via MalaCards
Search SYN3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SYN3

Genetic Association Database (GAD)
SYN3
Human Genome Epidemiology (HuGE) Navigator
SYN3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SYN3
genes like me logo Genes that share disorders with SYN3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SYN3 Gene

Publications for SYN3 Gene

  1. A third member of the synapsin gene family. (PMID: 9539796) Kao H.-T. … Greengard P. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3 4 67
  2. Association and expression study of synapsin III and schizophrenia. (PMID: 19766700) Chen Q. … Chen X. (Neurosci. Lett. 2009) 3 23
  3. Association between synapsin III gene promoter SNPs and multiple sclerosis in Basque patients. (PMID: 18755822) Otaegui D. … Lopez de Munain A. (Mult. Scler. 2009) 3 23
  4. Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci. (PMID: 25429064) He M. … Qi L. (Hum. Mol. Genet. 2015) 3
  5. No association of four candidate genetic variants in MnSOD and SYNIII with Parkinson's disease in two Chinese populations. (PMID: 24586301) Yu W.J. … Peng R. (PLoS ONE 2014) 3

Products for SYN3 Gene

Sources for SYN3 Gene

Back to Top

Content