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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SYN2 Gene

protein-coding   GIFtS: 58
GCID: GC03P012020

Synapsin II

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Synapsin II1 2 3
SYNII2
SYNIIa2
SYNIIb2
synapsin-22

External Ids:    HGNC: 114951   Entrez Gene: 68542   Ensembl: ENSG000001571527   OMIM: 6007555   UniProtKB: Q927773   

Export aliases for SYN2 gene to outside databases

Previous GC identifer: GC03P011976


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SYN2 Gene:
This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with
the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and
they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role
in several neuropsychiatric diseases. This member of the synapsin family encodes a neuron-specific phosphoprotein
that selectively binds to small synaptic vesicles in the presynaptic nerve terminal. The TIMP4 gene is located
within an intron of this gene and is transcribed in the opposite direction. Mutations in this gene may be
associated with abnormal presynaptic function and schizophrenia. Alternative splicing of this gene results in two
transcripts. (provided by RefSeq, Jul 2008)

GeneCards Summary for SYN2 Gene: 
SYN2 (synapsin II) is a protein-coding gene. Diseases associated with SYN2 include epilepsy syndrome, and schizophrenia, and among its related super-pathways are Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell and Norepinephrine Neurotransmitter Release Cycle. GO annotations related to this gene include catalytic activity and ATP binding.

UniProtKB/Swiss-Prot: SYN2_HUMAN, Q92777
Function: Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to
function in the regulation of neurotransmitter release (By similarity)

Gene Wiki entry for SYN2 (Synapsin 2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.2  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SYN2 gene promoter:
         STAT5B   AML1a   Pax-6   COUP   Lmo2   Arnt   GATA-2   S8   POU2F1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSYN2 promoter sequence
   Search SABiosciences Chromatin IP Primers for SYN2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SYN2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p25   Ensembl cytogenetic band:  3p25.2   HGNC cytogenetic band: 3p25.2

SYN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SYN2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P012020:  view genomic region     (about GC identifiers)

Start:
12,045,862 bp from pter      End:
12,233,532 bp from pter
Size:
187,671 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SYN2_HUMAN, Q92777 (See protein sequence)
Recommended Name: Synapsin-2  
Size: 582 amino acids; 62847 Da
Subunit: Interacts with CAPON (By similarity)
Subcellular location: Cell junction, synapse
Caution: There are several mRNAs and ESTs supporting this gene model. However, the genome sequence encoding the
N-terminal part contains several sequence discrepancies
Sequence caution: Sequence=AC022234; Type=Frameshift; Positions=71; Sequence=AC022234; Type=Miscellaneous
discrepancy; Note=Several in-frame stop codons;
Secondary accessions: A8MY98
Alternative splicing: 2 isoforms:  Q92777-1   Q92777-2   

Explore the universe of human proteins at neXtProt for SYN2: NX_Q92777

Explore proteomics data for SYN2 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylation at Ser-10 dissociates synapsins from synaptic vesicles (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q92777

  • SYN2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SYN2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_003169.2  NP_598328.1  
    Reactome Protein details: Q92777
    Human Recombinant Protein Products for SYN2: 
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    OriGene Custom Protein Services for SYN2
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    Novus Biologicals SYN2 Protein
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SYN2 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008021synaptic vesicle IEA--
    GO:0030054cell junction IEA--

    SYN2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/8 InterPro protein domains (see all 8):
     IPR019735 Synapsin_CS
     IPR020898 Synapsin_ATP-bd_dom
     IPR013815 ATP_grasp_subdomain_1
     IPR020897 Synapsin_pre-ATP-grasp_dom
     IPR019736 Synapsin_P_site

    Graphical View of Domain Structure for InterPro Entry Q92777

    ProtoNet protein and cluster: Q92777

    1 Blocks protein domain: IPB001359 Synapsin

    UniProtKB/Swiss-Prot: SYN2_HUMAN, Q92777
    Domain: The A region binds phospholipids with a preference for negatively charged species (By similarity)
    Similarity: Belongs to the synapsin family


    SYN2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SYN2_HUMAN, Q92777
    Function: Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to
    function in the regulation of neurotransmitter release (By similarity)

         Genatlas biochemistry entry for SYN2:
    synapsin II,synaptic vesicles associated phosphoprotein,with two alternative forms SYNIIA,SYNIIB,involved in the
    fine regulation of neurotransmitter release

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity IEA--
    GO:0005524ATP binding IEA--
         
    SYN2 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Syn2):
     behavior/neurological  nervous system 

    SYN2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for SYN2: Syn2tm1Kao Syn2tm1Sud

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SYN2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SYN2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SYN2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SYN2 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SYN2
    8/60 QIAGEN miScript miRNA Assays for microRNAs that regulate SYN2 (see all 60):
    hsa-miR-194* hsa-miR-3678-3p hsa-miR-607 hsa-miR-513a-5p hsa-miR-25 hsa-miR-30d hsa-miR-449a hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidSYN2 3' UTR sequence
    Inhib. RNA
    Products:
        
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                         Customized lentivirus expression plasmids for stable overexpression of SYN2 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYN2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SYN2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Transmission across Chemical Synapses
    Transmission across Chemical Synapses0.72
    Neuronal System0.67
    2Serotonin Neurotransmitter Release Cycle
    Serotonin Neurotransmitter Release Cycle0.60
    Dopamine Neurotransmitter Release Cycle0.60
    3GABA synthesis, release, reuptake and degradation
    Neurotransmitter Release Cycle0.53
    4Synaptic vesicle cycle
    Synaptic Vesicle Pathway0.50

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for SYN2
        Synaptic Vesicle Pathway

    5        Reactome Pathways for SYN2
        Dopamine Neurotransmitter Release Cycle
    Transmission across Chemical Synapses
    Neurotransmitter Release Cycle
    Neuronal System
    Serotonin Neurotransmitter Release Cycle



    SYN2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SYN2

    5/11 Interacting proteins for SYN2 (Q927773) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SYN1P176003I2D: score=4 
    SYN3O149943I2D: score=2 
    DLG4P783523I2D: score=1 
    GRID2O434243I2D: score=1 
    KCNMA1Q127913I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007268synaptic transmission TAS8964517
    GO:0007269neurotransmitter secretion IEA--

    SYN2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SYN2

    Search CenterWatch for drugs/clinical trials and news about SYN2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SYN2 gene (2 alternative transcripts): 
    NM_003178.4  NM_133625.3  

    Unigene Cluster for SYN2:

    Synapsin II
    Hs.445503  [show with all ESTs]
    Unigene Representative Sequence: NM_003178
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000426379(uc003bwm.3) ENST00000432424(uc003bwl.1) ENST00000424884
    ENST00000439861(uc003bwn.3) ENST00000447752 ENST00000425297
    miRNA
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    8/60 QIAGEN miScript miRNA Assays for microRNAs that regulate SYN2 (see all 60):
    hsa-miR-194* hsa-miR-3678-3p hsa-miR-607 hsa-miR-513a-5p hsa-miR-25 hsa-miR-30d hsa-miR-449a hsa-miR-30a
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    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SYN2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SYN2

    Additional mRNA sequence: 

    AB209088.1 AF077671.1 AF077737.1 AK091286.1 AK094464.1 AK295431.1 AK307469.1 BC040661.2 
    BC051307.1 U40215.1 

    9 DOTS entries:

    DT.453338  DT.100021464  DT.100698418  DT.100021463  DT.100021461  DT.70101862  DT.100021462  DT.100750686 
    DT.120943801 

    24/79 AceView cDNA sequences (see all 79):

    AI867893 BQ185580 BE220333 AA829792 BU728023 CB152289 AK091286 AA326223 
    AL119544 BC040661 BQ023793 BE468017 BX953201 AW207820 BX109563 BQ719955 
    BE466171 BX101205 AW592777 AW139618 T08236 AA694554 CK004946 AK094464 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SYN2 expression in normal human tissues (normalized intensities)      SYN2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCACTATGAC
    SYN2 Expression
    About this image


    SYN2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             orbitofrontal cortex   
     
     Fibroblast
             Human Dermal Fibroblasts-adult (HDF-a)   
     
     Dermis (Uncategorized)
             Human Dermal Fibroblasts-adult (HDF-a)   
     
     Amnion (Extraembryonic Tissues)
             Amnion-derived mesenchymal stem cells
     
     Testis (Reproductive System)

    See SYN2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SYN2

    SOURCE GeneReport for Unigene cluster: Hs.445503

    UniProtKB/Swiss-Prot: SYN2_HUMAN, Q92777
    Tissue specificity: Central and peripheral nervous systems

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SYN2 gene from 6/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Syn21 , 5 synapsin II1, 5 90.56(n)1
    95.68(a)1
      6 (53.20 cM)5
    209651  NM_001111015.11  NP_001104485.11 
     1151349025 
    chicken
    (Gallus gallus)
    Aves SYN21 synapsin II 78.48(n)
    81.83(a)
      415963  XM_003641989.1  XP_003642037.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia syn2-A2 synapsin IIa 79.9(n)    AF192752.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.134142 Transcribed sequence with weak similarity to protein more 79.07(n)    CK361225.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Syn1 , 3 neurotransmitter secretion3
    Synapsin1
    47(a)3
    49.49(n)1
    41.41(a)1
      412471  NM_169334.31  NP_731459.21 
    worm
    (Caenorhabditis elegans)
    Secernentea snn-11 Protein SNN-1 47.05(n)
    34.49(a)
      176987  NM_171276.2  NP_741326.1 


    ENSEMBL Gene Tree for SYN2 (if available)
    TreeFam Gene Tree for SYN2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SYN2 gene
    3 SIMAP similar genes for SYN2 using alignment to 2 protein entries:     SYN2_HUMAN (see all proteins):
    syn2    SYN3    SYN1

    SYN2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SYN2
    PGOHUM00000237940


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3708 SNPs in SYN2 are shown (see all 3708)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1883140081,2
    C--11978833(+) AAAGAC/TAACTA 2 -- us2k10--------
    rs1999091941,2
    --11978867(+) GCTTA-/CATTCT 2 -- us2k10--------
    rs1490022401,2
    --11978930(+) CACAGC/GATATG 2 -- us2k10--------
    rs176690621,2
    C,F,H--11978934(+) GGATAT/CGGAAC 2 -- us2k112Minor allele frequency- C:0.03NA NS EA 1088
    rs1932939191,2
    --11978964(+) ATTGAC/TGAAAG 2 -- us2k10--------
    rs26183991,2
    C,H--11979005(-) GCATGG/CAGAAG 2 -- us2k112Minor allele frequency- C:0.01NA WA CSA 139
    rs1849059381,2
    --11979134(+) ATGAGC/TCCCTC 2 -- us2k10--------
    rs117095881,2
    C,H--11979187(+) GCATTT/CCTCAC 2 -- us2k14Minor allele frequency- C:0.00NS EA 420
    rs76356431,2
    C,F--11979210(+) TCCTGT/CGTCTA 2 -- us2k15Minor allele frequency- C:0.46WA CSA 123
    rs1883021101,2
    --11979283(+) ATTCAC/TTTCAG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for SYN2 (12045862 - 12233532 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/17 variations for SYN2 (see all 17):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1007552CNV Deletion20482838
    esv1015927CNV Deletion17803354
    esv2724931CNV Deletion23290073
    dgv810e201CNV Deletion23290073
    dgv850e199CNV Deletion23128226
    esv2504613CNV Deletion19546169
    esv2193425CNV Deletion18987734
    esv2724932CNV Deletion23290073
    esv274410CNV Insertion20981092
    esv2584673CNV Insertion19546169

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600755   
    OMIM disorders: 181500  
    6 diseases for SYN2:    About MalaCards
    epilepsy syndrome    schizophrenia    neuronitis    bipolar disorder
    intrahepatic cholangiocarcinoma    cholangiocarcinoma

    1 disease from the University of Copenhagen DISEASES database for SYN2:
    Schizophrenia

    SYN2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SYN2
    Human Genome Epidemiology (HuGE) Navigator: SYN2 (10 documents)

    Export disorders for SYN2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SYN2 gene, integrated from 9 sources (see all 39):
    (articles sorted by number of sources associating them with SYN2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Association study of polymorphisms in synaptic vesicle-associated genes, SYN2 and CPLX2, with schizophrenia. (PubMed id 16131404)1, 4, 9 Lee H.J....Fukumaki Y. (2005)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. Association of intronic polymorphism rs3773364 A>G in synapsin-2 gene with idiopathic epilepsy. (PubMed id 20034013)1, 4 Lakhan R....Mittal B. (2010)
    4. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    5. No association between bipolar disorder and syngr1 or synapsin II polymorphisms in the Han Chinese population. (PubMed id 19665806)1, 4 Wang Y....Li S. (2009)
    6. Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. (PubMed id 18372903)1, 4 Zeggini E....Altshuler D. (2008)
    7. Multicentre search for genetic susceptibility loci in sporadic epilepsy syndrome and seizure types: a case-control study. (PubMed id 17913586)1, 4 Cavalleri G.L....Goldstein D.B. (2007)
    8. Positive association between synapsin II and schizophrenia. (PubMed id 15271586)1, 4 Chen Q....He L. (2004)
    9. Cloning of cDNAs encoding human synapsins IIa and IIb. (PubMed id 10565545)1, 2 Porton B.... Greengard P. (1999)
    10. Cloning and sequencing analysis of a human synapsin IIb-encoding brain cDNA. (PubMed id 8964517)1, 2 Xie Y. (1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6854 HGNC: 11495 AceView: SYN2 Ensembl:ENSG00000157152 euGenes: HUgn6854
    ECgene: SYN2 H-InvDB: SYN2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SYN2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SYN2 gene:
    Search GeneIP for patents involving SYN2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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