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Aliases for SYN2 Gene

Aliases for SYN2 Gene

  • Synapsin II 2 3 4 5
  • Synapsin-2 3
  • SYNII 3

External Ids for SYN2 Gene

Previous GeneCards Identifiers for SYN2 Gene

  • GC03P011976

Summaries for SYN2 Gene

Entrez Gene Summary for SYN2 Gene

  • This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. This member of the synapsin family encodes a neuron-specific phosphoprotein that selectively binds to small synaptic vesicles in the presynaptic nerve terminal. Polymorphisms in this gene are associated with abnormal presynaptic function and related neuronal disorders, including autism, epilepsy, bipolar disorder and schizophrenia. Alternative splicing of this gene results in multiple transcript variants. The tissue inhibitor of metalloproteinase 4 gene is located within an intron of this gene and is transcribed in the opposite direction. [provided by RefSeq, Feb 2014]

GeneCards Summary for SYN2 Gene

SYN2 (Synapsin II) is a Protein Coding gene. Diseases associated with SYN2 include Schizophrenia. Among its related pathways are Neurotransmitter Release Cycle and Synaptic vesicle cycle. An important paralog of this gene is SYN3.

UniProtKB/Swiss-Prot for SYN2 Gene

  • Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. May play a role in noradrenaline secretion by sympathetic neurons (By similarity).

Gene Wiki entry for SYN2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYN2 Gene

Genomics for SYN2 Gene

Regulatory Elements for SYN2 Gene

Enhancers for SYN2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around SYN2 on UCSC Golden Path with GeneCards custom track

Promoters for SYN2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for SYN2 Gene

Chromosome:
3
Start:
12,004,360 bp from pter
End:
12,192,032 bp from pter
Size:
187,673 bases
Orientation:
Plus strand

Genomic View for SYN2 Gene

Genes around SYN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SYN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SYN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYN2 Gene

Proteins for SYN2 Gene

  • Protein details for SYN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92777-SYN2_HUMAN
    Recommended name:
    Synapsin-2
    Protein Accession:
    Q92777
    Secondary Accessions:
    • A8MY98

    Protein attributes for SYN2 Gene

    Size:
    582 amino acids
    Molecular mass:
    62847 Da
    Quaternary structure:
    • Interacts with CAPON.
    SequenceCaution:
    • Sequence=AC022234; Type=Frameshift; Positions=71; Evidence={ECO:0000305}; Sequence=AC022234; Type=Miscellaneous discrepancy; Note=Several in-frame stop codons.; Evidence={ECO:0000305};

    Alternative splice isoforms for SYN2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SYN2 Gene

Post-translational modifications for SYN2 Gene

  • Phosphorylation at Ser-10 dissociates synapsins from synaptic vesicles. Phosphorylation at Ser-425 by MAPK1/ERK2 and/or MAPK3/ERK1 may play a role in noradrenaline secretion by sympathetic neurons (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SYN2 Gene

No data available for DME Specific Peptides for SYN2 Gene

Domains & Families for SYN2 Gene

Gene Families for SYN2 Gene

Suggested Antigen Peptide Sequences for SYN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92777

UniProtKB/Swiss-Prot:

SYN2_HUMAN :
  • The A region binds phospholipids with a preference for negatively charged species.
  • Belongs to the synapsin family.
Domain:
  • The A region binds phospholipids with a preference for negatively charged species.
Family:
  • Belongs to the synapsin family.
genes like me logo Genes that share domains with SYN2: view

Function for SYN2 Gene

Molecular function for SYN2 Gene

GENATLAS Biochemistry:
synapsin II,synaptic vesicles associated phosphoprotein,with two alternative forms SYNIIA,SYNIIB,involved in the fine regulation of neurotransmitter release
UniProtKB/Swiss-Prot Function:
Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. May play a role in noradrenaline secretion by sympathetic neurons (By similarity).

Gene Ontology (GO) - Molecular Function for SYN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
GO:0005524 ATP binding TAS 15217342
genes like me logo Genes that share ontologies with SYN2: view
genes like me logo Genes that share phenotypes with SYN2: view

Animal Models for SYN2 Gene

MGI Knock Outs for SYN2:

Animal Model Products

CRISPR Products

miRNA for SYN2 Gene

miRTarBase miRNAs that target SYN2

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SYN2 Gene

Localization for SYN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYN2 Gene

Cell junction, synapse.

Gene Ontology (GO) - Cellular Components for SYN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0030054 cell junction IEA --
GO:0030672 synaptic vesicle membrane IEA,ISS --
GO:0031201 SNARE complex IEA --
GO:0043209 myelin sheath IEA --
genes like me logo Genes that share ontologies with SYN2: view

No data available for Subcellular locations from COMPARTMENTS for SYN2 Gene

Pathways & Interactions for SYN2 Gene

genes like me logo Genes that share pathways with SYN2: view

Pathways by source for SYN2 Gene

Interacting Proteins for SYN2 Gene

Gene Ontology (GO) - Biological Process for SYN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007268 chemical synaptic transmission TAS 8964517
GO:0007269 neurotransmitter secretion IEA,ISS --
genes like me logo Genes that share ontologies with SYN2: view

No data available for SIGNOR curated interactions for SYN2 Gene

Drugs & Compounds for SYN2 Gene

No Compound Related Data Available

Transcripts for SYN2 Gene

Unigene Clusters for SYN2 Gene

Synapsin II:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SYN2 Gene

No ASD Table

Relevant External Links for SYN2 Gene

GeneLoc Exon Structure for
SYN2
ECgene alternative splicing isoforms for
SYN2

Expression for SYN2 Gene

mRNA expression in normal human tissues for SYN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SYN2 Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (x7.4), Brain - Frontal Cortex (BA9) (x6.9), Brain - Cortex (x5.9), Brain - Amygdala (x5.4), and Brain - Nucleus accumbens (basal ganglia) (x4.2).

Protein differential expression in normal tissues from HIPED for SYN2 Gene

This gene is overexpressed in Brain (51.9) and Frontal cortex (16.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SYN2 Gene



Protein tissue co-expression partners for SYN2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SYN2 Gene:

SYN2

SOURCE GeneReport for Unigene cluster for SYN2 Gene:

Hs.445503

mRNA Expression by UniProt/SwissProt for SYN2 Gene:

Q92777-SYN2_HUMAN
Tissue specificity: Central and peripheral nervous systems.
genes like me logo Genes that share expression patterns with SYN2: view

Primer Products

Orthologs for SYN2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SYN2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SYN2 34
  • 91.81 (n)
  • 94.96 (a)
dog
(Canis familiaris)
Mammalia SYN2 34
  • 91.44 (n)
  • 94.06 (a)
mouse
(Mus musculus)
Mammalia Syn2 34
  • 88.66 (n)
  • 92.57 (a)
Syn2 16
chimpanzee
(Pan troglodytes)
Mammalia SYN2 34
  • 97.59 (n)
  • 97.59 (a)
rat
(Rattus norvegicus)
Mammalia Syn2 34
  • 89 (n)
  • 91.88 (a)
chicken
(Gallus gallus)
Aves SYN2 34
  • 75.8 (n)
  • 77.76 (a)
African clawed frog
(Xenopus laevis)
Amphibia syn2-A 34
zebrafish
(Danio rerio)
Actinopterygii Dr.13414 34
syn2a 34
  • 69.34 (n)
  • 68.16 (a)
fruit fly
(Drosophila melanogaster)
Insecta Syn 36
  • 47 (a)
Species where no ortholog for SYN2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SYN2 Gene

ENSEMBL:
Gene Tree for SYN2 (if available)
TreeFam:
Gene Tree for SYN2 (if available)

Paralogs for SYN2 Gene

Paralogs for SYN2 Gene

(3) SIMAP similar genes for SYN2 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for SYN2 Gene

genes like me logo Genes that share paralogs with SYN2: view

Variants for SYN2 Gene

Sequence variations from dbSNP and Humsavar for SYN2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs794999 - 12,187,515(+) CCACC(A/G)CCCAC reference, missense
rs366270 -- 12,097,389(+) ataac(A/G)aggtc intron-variant
rs366950 -- 12,116,744(+) ATACT(C/T)TAttt intron-variant
rs369289 -- 12,086,036(-) aaata(A/T)accca intron-variant
rs370126 -- 12,078,472(-) aaaaa(C/T)taact intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SYN2 Gene

Variant ID Type Subtype PubMed ID
dgv1360e212 CNV loss 25503493
dgv763e201 CNV deletion 23290073
dgv850e199 CNV deletion 23128226
esv1007552 CNV deletion 20482838
esv1015927 CNV deletion 17803354
esv1768590 CNV insertion 17803354
esv2193425 CNV deletion 18987734
esv2504613 CNV deletion 19546169
esv2584673 CNV insertion 19546169
esv2724931 CNV deletion 23290073
esv2724932 CNV deletion 23290073
esv3030297 CNV deletion 24192839
esv3310138 CNV mobile element insertion 20981092
esv3383197 CNV insertion 20981092
esv3561484 CNV deletion 23714750
esv3568616 CNV loss 25503493
esv3595315 CNV loss 21293372
nsv1073205 CNV deletion 25765185
nsv1112379 CNV deletion 24896259
nsv1139090 CNV deletion 24896259
nsv1147269 CNV deletion 26484159
nsv236690 CNV deletion 16902084
nsv236830 CNV deletion 16902084
nsv460427 CNV loss 19166990
nsv519277 CNV loss 19592680
nsv589698 CNV loss 21841781
nsv589699 CNV loss 21841781
nsv7351 OTHER inversion 18451855
nsv979803 CNV duplication 23825009

Relevant External Links for SYN2 Gene

Human Gene Mutation Database (HGMD)
SYN2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SYN2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for SYN2 Gene

Disorders for SYN2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SYN2 Gene - From: OMIM and GeneCards

Disorder Aliases PubMed IDs
schizophrenia
  • schizophrenia 12
- elite association - COSMIC cancer census association via MalaCards
Search SYN2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SYN2

Genetic Association Database (GAD)
SYN2
Human Genome Epidemiology (HuGE) Navigator
SYN2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SYN2
genes like me logo Genes that share disorders with SYN2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SYN2 Gene

Publications for SYN2 Gene

  1. Association study of polymorphisms in synaptic vesicle-associated genes, SYN2 and CPLX2, with schizophrenia. (PMID: 16131404) Lee H.J. … Fukumaki Y. (Behav Brain Funct 2005) 3 22 46 65
  2. Association of intronic polymorphism rs3773364 A>G in synapsin-2 gene with idiopathic epilepsy. (PMID: 20034013) Lakhan R. … Mittal B. (Synapse 2010) 3 46 65
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 65
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 65
  5. No association between bipolar disorder and syngr1 or synapsin II polymorphisms in the Han Chinese population. (PMID: 19665806) Wang Y. … Li S. (Psychiatry Res 2009) 3 46 65

Products for SYN2 Gene

Sources for SYN2 Gene

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