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SYN2 Gene

protein-coding   GIFtS: 58
GCID: GC03P012020

Synapsin II

  See SYN2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Synapsin II1 2 3
SYNII2
synapsin-22

External Ids:    HGNC: 114951   Entrez Gene: 68542   Ensembl: ENSG000001571527   OMIM: 6007555   UniProtKB: Q927773   

Export aliases for SYN2 gene to outside databases

Previous GC identifer: GC03P011976


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SYN2 Gene:
This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with
the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and
they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role
in several neuropsychiatric diseases. This member of the synapsin family encodes a neuron-specific phosphoprotein
that selectively binds to small synaptic vesicles in the presynaptic nerve terminal. Polymorphisms in this gene
are associated with abnormal presynaptic function and related neuronal disorders, including autism, epilepsy,
bipolar disorder and schizophrenia. Alternative splicing of this gene results in multiple transcript variants.
The tissue inhibitor of metalloproteinase 4 gene is located within an intron of this gene and is transcribed in
the opposite direction. (provided by RefSeq, Feb 2014)

GeneCards Summary for SYN2 Gene:
SYN2 (synapsin II) is a protein-coding gene. Diseases associated with SYN2 include schizophrenia, and bipolar disorder.

UniProtKB/Swiss-Prot: SYN2_HUMAN, Q92777
Function: Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to
function in the regulation of neurotransmitter release (By similarity)

Gene Wiki entry for SYN2 (Synapsin 2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SYN2 gene promoter:
         STAT5B   AML1a   Pax-6   COUP   Lmo2   Arnt   GATA-2   S8   POU2F1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSYN2 promoter sequence
   Search Chromatin IP Primers for SYN2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SYN2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p25   Ensembl cytogenetic band:  3p25.2   HGNC cytogenetic band: 3p25.2

SYN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SYN2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P012020:  view genomic region     (about GC identifiers)

Start:
12,045,862 bp from pter      End:
12,233,532 bp from pter
Size:
187,671 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SYN2_HUMAN, Q92777 (See protein sequence)
Recommended Name: Synapsin-2  
Size: 582 amino acids; 62847 Da
Subunit: Interacts with CAPON (By similarity)
Caution: There are several mRNAs and ESTs supporting this gene model. However, the genome sequence encoding the
N-terminal part contains several sequence discrepancies
Sequence caution: Sequence=AC022234; Type=Frameshift; Positions=71; Sequence=AC022234; Type=Miscellaneous
discrepancy; Note=Several in-frame stop codons;
Secondary accessions: A8MY98
Alternative splicing: 2 isoforms:  Q92777-1   Q92777-2   

Explore the universe of human proteins at neXtProt for SYN2: NX_Q92777

Explore proteomics data for SYN2 at MOPED

Post-translational modifications: 

  • Phosphorylation at Ser-10 dissociates synapsins from synaptic vesicles (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SYN2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_003169.2  NP_598328.1  
    Reactome Protein details: Q92777

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 9):
     IPR019735 Synapsin_CS
     IPR020898 Synapsin_ATP-bd_dom
     IPR013815 ATP_grasp_subdomain_1
     IPR028710 Syn2
     IPR020897 Synapsin_pre-ATP-grasp_dom

    Graphical View of Domain Structure for InterPro Entry Q92777

    ProtoNet protein and cluster: Q92777

    1 Blocks protein domain: IPB001359 Synapsin

    UniProtKB/Swiss-Prot: SYN2_HUMAN, Q92777
    Domain: The A region binds phospholipids with a preference for negatively charged species (By similarity)
    Similarity: Belongs to the synapsin family


    Find genes that share domains with SYN2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SYN2_HUMAN, Q92777
    Function: Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to
    function in the regulation of neurotransmitter release (By similarity)

         Genatlas biochemistry entry for SYN2:
    synapsin II,synaptic vesicles associated phosphoprotein,with two alternative forms SYNIIA,SYNIIB,involved in the
    fine regulation of neurotransmitter release

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity IEA--
    GO:0005524ATP binding IEA--
         
    Find genes that share ontologies with SYN2           About GenesLikeMe


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Syn2):
     behavior/neurological  nervous system  taste/olfaction 

    Find genes that share phenotypes with SYN2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for SYN2: Syn2tm1Kao Syn2tm1Sud

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SYN2
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    Selected qRT-PCR Assays for microRNAs that regulate SYN2 (see all 60):
    hsa-miR-194* hsa-miR-3678-3p hsa-miR-607 hsa-miR-513a-5p hsa-miR-25 hsa-miR-30d hsa-miR-449a hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidSYN2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SYN2

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SYN2_HUMAN, Q92777: Cell junction, synapse
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    mitochondrion3
    cytoskeleton1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008021synaptic vesicle IEA--
    GO:0030054cell junction IEA--

    Find genes that share ontologies with SYN2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SYN2 About    
    See pathways by source

    SuperPathContained pathways About
    1Neurotransmitter Release Cycle
    Serotonin Neurotransmitter Release Cycle0.40
    Dopamine Neurotransmitter Release Cycle0.00
    Neurotransmitter Release Cycle0.32
    2Transmission across Chemical Synapses
    Transmission across Chemical Synapses0.72
    Neuronal System0.68
    3Synaptic vesicle cycle
    Synaptic Vesicle Pathway0.50


    Find genes that share SuperPaths with SYN2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for SYN2
        Synaptic Vesicle Pathway

    2 Reactome Pathways for SYN2
        Dopamine Neurotransmitter Release Cycle
    Serotonin Neurotransmitter Release Cycle


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SYN2
    Interactions:

        Search GeneGlobe Interaction Network for SYN2

    Selected Interacting proteins for SYN2 (Q927773) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SYN1P176003I2D: score=4 
    SYN3O149943I2D: score=2 
    DLG4P783523I2D: score=1 
    GRID2O434243I2D: score=1 
    KCNMA1Q127913I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007268synaptic transmission TAS8964517
    GO:0007269neurotransmitter secretion IEA--

    Find genes that share ontologies with SYN2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SYN2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SYN2 gene (2 alternative transcripts): 
    NM_003178.5  NM_133625.4  

    Unigene Cluster for SYN2:

    Synapsin II
    Hs.445503  [show with all ESTs]
    Unigene Representative Sequence: NM_003178
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000426379(processed_transcript) ENST00000432424(processed_transcript) ENST00000424884(processed_transcript) ENST00000439861(processed_transcript) ENST00000447752(processed_transcript)
    ENST00000425297(processed_transcript)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate SYN2 (see all 60):
    hsa-miR-194* hsa-miR-3678-3p hsa-miR-607 hsa-miR-513a-5p hsa-miR-25 hsa-miR-30d hsa-miR-449a hsa-miR-30a
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    Inhib. RNA
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    Additional mRNA sequence: 

    AB209088.1 AF077671.1 AF077737.1 AK091286.1 AK094464.1 AK295431.1 AK307469.1 BC040661.2 
    BC051307.1 U40215.1 

    9 DOTS entries:

    DT.453338  DT.100021464  DT.100698418  DT.100021463  DT.100021461  DT.70101862  DT.100021462  DT.100750686 
    DT.120943801 

    Selected AceView cDNA sequences (see all 79):

    BC040661 BQ023793 BQ719955 AK091286 AA829792 BE466171 AW207820 BX109563 
    BE468017 AL119544 BE220333 AA326223 BQ185580 BU728023 CB152289 AI867893 
    BX953201 AI792940 T08236 BQ716653 BG701972 BX101205 CD616516 M78985 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SYN2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCACTATGAC
    SYN2 Expression
    About this image


    SYN2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     NULL (Uncategorized)    fully expand to see all 3 entries
             B27-induced amniotic-derived mesenchymal stem cells
     
     Eye (Sensory Organs)
             Lens
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Motor Neurons (Nervous System)
             Motor neuron-like precursor cells
     
     Spinal Cord (Nervous System)
             Motor neuron-like precursor cells
    SYN2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SYN2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.445503

    UniProtKB/Swiss-Prot: SYN2_HUMAN, Q92777
    Tissue specificity: Central and peripheral nervous systems

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SYN2 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Syn21 , 5 synapsin II1, 5 88.66(n)1
    92.57(a)1
      6 (53.20 cM)5
    209651  NM_001111015.11  NP_001104485.11 
     1151349025 
    chicken
    (Gallus gallus)
    Aves SYN21 synapsin II 75.8(n)
    77.76(a)
      415963  XM_003641989.2  XP_003642037.2 
    African clawed frog
    (Xenopus laevis)
    Amphibia syn2-A2 synapsin IIa 79.9(n)    AF192752.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.134142 Transcribed sequence with weak similarity to protein more 79.07(n)    CK361225.1 


    ENSEMBL Gene Tree for SYN2 (if available)
    TreeFam Gene Tree for SYN2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SYN2 gene
    3 SIMAP similar genes for SYN2 using alignment to 2 protein entries:     SYN2_HUMAN (see all proteins):
    syn2    SYN3    SYN1

    Find genes that share paralogs with SYN2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for SYN2
    PGOHUM00000237940


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SYN2 (see all 3708)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1883140081,2
    C--11978833(+) AAAGAC/TAACTA 2 -- us2k10--------
    rs1999091941,2
    --11978867(+) GCTTA-/CATTCT 2 -- us2k10--------
    rs1490022401,2
    --11978930(+) CACAGC/GATATG 2 -- us2k10--------
    rs176690621,2
    C,F,H--11978934(+) GGATAT/CGGAAC 2 -- us2k112Minor allele frequency- C:0.03NA NS EA 1088
    rs1932939191,2
    --11978964(+) ATTGAC/TGAAAG 2 -- us2k10--------
    rs26183991,2
    C,H--11979005(-) GCATGG/CAGAAG 2 -- us2k112Minor allele frequency- C:0.01NA WA CSA 139
    rs1849059381,2
    --11979134(+) ATGAGC/TCCCTC 2 -- us2k10--------
    rs117095881,2
    C,H--11979187(+) GCATTT/CCTCAC 2 -- us2k14Minor allele frequency- C:0.00NS EA 420
    rs76356431,2
    C,F--11979210(+) TCCTGT/CGTCTA 2 -- us2k15Minor allele frequency- C:0.46WA CSA 123
    rs1883021101,2
    --11979283(+) ATTCAC/TTTCAG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for SYN2 (12045862 - 12233532 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SYN2 (see all 17):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1007552CNV Deletion20482838
    esv1015927CNV Deletion17803354
    esv2724931CNV Deletion23290073
    dgv810e201CNV Deletion23290073
    dgv850e199CNV Deletion23128226
    esv2504613CNV Deletion19546169
    esv2193425CNV Deletion18987734
    esv2724932CNV Deletion23290073
    esv274410CNV Insertion20981092
    esv2584673CNV Insertion19546169

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600755   
    OMIM disorders: 181500  
    2 diseases for SYN2:    
    About MalaCards
    schizophrenia    bipolar disorder

    1 disease from the University of Copenhagen DISEASES database for SYN2:
    Schizophrenia

    Find genes that share disorders with SYN2           About GenesLikeMe

    Genetic Association Database (GAD): SYN2
    Human Genome Epidemiology (HuGE) Navigator: SYN2 (10 documents)

    Export disorders for SYN2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SYN2 gene, integrated from 10 sources (see all 45):
    (articles sorted by number of sources associating them with SYN2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Association study of polymorphisms in synaptic vesicle-associated genes, SYN2 and CPLX2, with schizophrenia. (PubMed id 16131404)1, 4, 9 Lee H.J....Fukumaki Y. (Behav Brain Funct 2005)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Association of intronic polymorphism rs3773364 A&gt;G in synapsin-2 gene with idiopathic epilepsy. (PubMed id 20034013)1, 4 Lakhan R....Mittal B. (Synapse 2010)
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    5. No association between bipolar disorder and syngr1 or synapsin II polymorphisms in the Han Chinese population. (PubMed id 19665806)1, 4 Wang Y....Li S. (Psychiatry Res 2009)
    6. Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. (PubMed id 18372903)1, 4 Zeggini E....Altshuler D. (Nat. Genet. 2008)
    7. Multicentre search for genetic susceptibility loci in sporadic epilepsy syndrome and seizure types: a case-control study. (PubMed id 17913586)1, 4 Cavalleri G.L....Goldstein D.B. (Lancet Neurol 2007)
    8. Positive association between synapsin II and schizophrenia. (PubMed id 15271586)1, 4 Chen Q....He L. (Biol. Psychiatry 2004)
    9. Cloning of cDNAs encoding human synapsins IIa and IIb. (PubMed id 10565545)1, 2 Porton B.... Greengard P. (DNA Seq. 1999)
    10. Cloning and sequencing analysis of a human synapsin IIb-encoding brain cDNA. (PubMed id 8964517)1, 2 Xie Y. (Gene 1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6854 HGNC: 11495 AceView: SYN2 Ensembl:ENSG00000157152 euGenes: HUgn6854
    ECgene: SYN2 H-InvDB: SYN2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SYN2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SYN2 gene:
    Search GeneIP for patents involving SYN2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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