SYN2 Gene

Aliases
for SYN2 gene

Previous GC identifer: GC03P011976

Summaries
for SYN2 gene

Genomic Views
for SYN2 gene

RefSeq DNA sequence:

NC_000003.11  NC_018914.1  NT_022517.18  

SwitchGear Promoter luciferase reporter plasmid: SYN2 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SYN2

SYN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P012020:  view genomic region     (about GC identifiers)

Proteins
for SYN2 gene

Explore the universe of human proteins at neXtProt for SYN2: NX_Q92777

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for SYN2
	GenScript Custom Purified and Recombinant Proteins Services for SYN2
	Novus Biologicals SYN2 Protein
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SYN2

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	OriGene Antibodies (see all 2): SYN2 OriGene Custom Antibody Services for SYN2
	GenScript Custom Superior Antibodies Services for SYN2
	Novus Biologicals SYN2 Antibodies
	Abcam antibodies for SYN2
	Uscn Antibodies for SYN2
	ThermoFisher Antibodies for SYN2

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for SYN2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for SYN2

Protein Domains /
Families
for SYN2 gene

ProtoNet protein and cluster: Q92777

Function
for SYN2 gene

miRNA Products:		OriGene 3'-UTR Clone (see all 2): SYN2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SYN2
		8/60 QIAGEN miScript miRNA Assays for microRNAs that regulate SYN2 (see all 60):
		hsa-miR-194* hsa-miR-3678-3p hsa-miR-607 hsa-miR-513a-5p hsa-miR-25 hsa-miR-30d hsa-miR-449a hsa-miR-30a
		SwitchGear 3'UTR luciferase reporter plasmid: SYN2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SYN2 (see all 7) OriGene shRNA RFP: SYN2 OriGene siRNA: SYN2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SYN2

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for SYN2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SYN2 (see all 7) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SYN2 (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): SYN2 (NM_133625)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SYN2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYN2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SYN2
		Search LifeMap BioReagents cell lines for SYN2

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYN2

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

(inferred from 2 alleles) (MGI details for Syn2)

Pathways & Interactions
for SYN2 gene

	Super-pathway	contained gene-specific pathways
1	Serotonin Neurotransmitter Release Cycle	Serotonin Neurotransmitter Release Cycle 1.00 Dopamine Neurotransmitter Release Cycle 1.00
2	Transmission across Chemical Synapses	Transmission across Chemical Synapses 1.00 Neuronal System 0.67
3	Synaptic Vesicle Pathway	Synaptic Vesicle Pathway 1.00
4	GABA synthesis, release, reuptake and degradation	Neurotransmitter Release Cycle 0.53

1 BioSystems Pathway for SYN2

Synaptic Vesicle Pathway

5        Reactome Pathways for SYN2

	Dopamine Neurotransmitter Release Cycle
	Transmission across Chemical Synapses
	Neurotransmitter Release Cycle
	Neuronal System
	Serotonin Neurotransmitter Release Cycle

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

Drugs & Compounds
for SYN2 gene

Transcripts
for SYN2 gene

Expression
for SYN2 gene

SYN2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCACTATGAC

1 LifeMap In Vivo Development Anatomical Compartment/Cell
	Tissue Anatomical Compartment Cell			Category (developmental path)
	EyeLens			Eye
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SYN2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SYN2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SYN2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SYN2

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYN2

Orthologs
for SYN2 gene

Paralogs
for SYN2 gene

Paralogs for SYN2 gene

3 SIMAP similar genes for SYN2 using alignment to 3 protein entries:     SYN2_HUMAN (see all proteins):

syn2    SYN3    SYN1

SYN2 for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for SYN2
PGOHUM00000237940

Genomic Variants
for SYN2 gene

10/3047 NCBI SNPs in SYN2 are shown (see all 3047)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs176690621,2	C,F,H,	--	11977178(+)	GGATAT/CGGAAC	2	--	us2k1		12		NA NS EA	1088
rs117095881,2	C,H	--	11977431(+)	GCATTT/CCTCAC	2	--	us2k1		4		NS EA	420
rs76356431,2	C,	--	11977454(+)	TCCTGT/CGTCTA	2	--	us2k1		5		WA CSA	123
rs38890031,2	C,F,H,	--	11977916(+)	tattgA/Ttccag	2	--	us2k1 tfbs3		17		NS EA NA WA CSA	1636
rs67914851,2	C	--	11977967(+)	TGCTGT/GGTCCT	2	--	us2k1		2		NA	4
rs790446341,2		--	11978342(+)	ACACAC/GCCCAC	2	--	us2k1		1		NA	120
rs731356261,2	C,	--	11980032(+)	AAAAAG/CGTTTA	2	--	int1		2		WA	120
rs731356271,2	C,F,	--	11980198(+)	GGCTTG/ATTCCC	2	--	int1		3		WA	122
rs731356281,2	C,	--	11980361(+)	TTTTTG/CTAGCT	2	--	int1		1		WA	2
rs782099851,2		--	11981071(+)	TGCATA/GTGATA	2	--	int1		0	--	--	--	--

HapMap Linkage Disequilibrium report for SYN2 (12045862 - 12233532 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for SYN2
     4 CNVs: 98236 6161 50912 98235
     1 Inversion: 37239

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SYN2

DNA2.0 Custom Variant and Variant Library Synthesis for SYN2

Disorders / Diseases
for SYN2 gene

Publications
for SYN2 gene

PubMed articles for SYN2 gene, integrated from 9 sources (see all 38): (articles sorted by number of sources associating them with SYN2)

Utopia: connect your pdf to the dynamic world of online information

1. Association study of polymorphisms in synaptic vesicle-associated genes, SYN2 and CPLX2, with schizophrenia. (PubMed id 16131404)^{1, 4, 9} Lee H.J....Fukumaki Y. (2005)
2. Positive association between synapsin II and schizophrenia. (PubMed id 15271586)^{1, 4} Chen Q....He L. (2004)
3. Cloning of cDNAs encoding human synapsins IIa and IIb. (PubMed id 10565545)^{1, 2} Porton B.... Greengard P. (1999)
4. Cloning and sequencing analysis of a human synapsin IIb-encoding brain cDNA. (PubMed id 8964517)^{1, 2} Xie Y. (1996)
5. Localization of the synapsin II (SYN2) gene to human chromosome 3 and mouse chromosome 6. (PubMed id 8530057)^{1, 3} Li L....Jenkins N.A. (1995)
6. Association of synapsin 2 with schizophrenia in families of Northern European ancestry. (PubMed id 17766091)^{1, 9} Saviouk V....Brzustowicz L.M. (2007)
7. Synapsin II is involved in the molecular pathway of li thium treatment in bipolar disorder. (PubMed id 22384280)¹ Cruceanu C....Turecki G. (2012)
8. A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resi stance. (PubMed id 22581228)¹ Manning A.K....Langenberg C. (2012)
9. Lack of association between synapsin II (SYN2) gene po lymorphism and susceptibility epilepsy: a case-control study and meta-analysis. (PubMed id 21465568)¹ Haerian B.S....Mohamed Z. (2011)
10. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)

External Searches for SYN2 gene

Genome Databases showing SYN2 gene

Other Databases showing SYN2 gene

Specialized Databases showing SYN2 gene

Products
for SYN2 gene