External Ids for SYMPK Gene
Previous GeneCards Identifiers for SYMPK Gene
This gene encodes a nuclear protein that functions in the regulation of polyadenylation and promotes gene expression. The protein forms a high-molecular weight complex with components of the polyadenylation machinery. It is thought to serve as a scaffold for recruiting regulatory factors to the polyadenylation complex. It also participates in 3'-end maturation of histone mRNAs, which do not undergo polyadenylation. The protein also localizes to the cytoplasmic plaques of tight junctions in some cell types. [provided by RefSeq, Jul 2008]
GeneCards Summary for SYMPK Gene
SYMPK (Symplekin) is a Protein Coding gene. Diseases associated with SYMPK include Vein Disease. Among its related pathways are Transport of the SLBP independent Mature mRNA and Tight junction. GO annotations related to this gene include binding.
UniProtKB/Swiss-Prot for SYMPK Gene
Scaffold protein that functions as a component of a multimolecular complex involved in histone mRNA 3-end processing. Specific component of the tight junction (TJ) plaque, but might not be an exclusively junctional component. May have a house-keeping rule. Is involved in pre-mRNA polyadenylation. Enhances SSU72 phosphatase activity.