External Ids for SYMPK Gene
Previous GeneCards Identifiers for SYMPK Gene
This gene encodes a nuclear protein that functions in the regulation of polyadenylation and promotes gene expression. The protein forms a high-molecular weight complex with components of the polyadenylation machinery. It is thought to serve as a scaffold for recruiting regulatory factors to the polyadenylation complex. It also participates in 3'-end maturation of histone mRNAs, which do not undergo polyadenylation. The protein also localizes to the cytoplasmic plaques of tight junctions in some cell types. [provided by RefSeq, Jul 2008]
GeneCards Summary for SYMPK Gene
SYMPK (Symplekin) is a Protein Coding gene. Diseases associated with SYMPK include Vein Disease. Among its related pathways are Tight junction and mRNA surveillance pathway. GO annotations related to this gene include binding.
UniProtKB/Swiss-Prot for SYMPK Gene
Scaffold protein that functions as a component of a multimolecular complex involved in histone mRNA 3-end processing. Specific component of the tight junction (TJ) plaque, but might not be an exclusively junctional component. May have a house-keeping rule. Is involved in pre-mRNA polyadenylation. Enhances SSU72 phosphatase activity.