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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SYMPK Gene

protein-coding GIFtS: 54
GCID: GC19M046318

symplekin

Explore 7 diseases affiliated with
SYMPK via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Symplekin¹
SPK¹ ² ³ ⁵
SYM¹ ²

External Ids:	HGNC: 22935¹	Entrez Gene: 8189²	Ensembl: ENSG00000125755⁷	OMIM: 602388⁵	UniProtKB: Q92797³

Export aliases for SYMPK gene to outside databases

Previous GC identifers: GC19M050994 GC19M051010 GC19M042747

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SYMPK:

This gene encodes a nuclear protein that functions in the regulation of polyadenylation and promotes gene expression.

The protein forms a high-molecular weight complex with components of the polyadenylation machinery. It is thought to

serve as a scaffold for recruiting regulatory factors to the polyadenylation complex. It also participates in 3'-end

maturation of histone mRNAs, which do not undergo polyadenylation. The protein also localizes to the cytoplasmic

plaques of tight junctions in some cell types. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: SYMPK_HUMAN, Q92797

Function: Scaffold protein that functions as a component of a multimolecular complex involved in histone mRNA 3'-end

processing. Specific component of the tight junction (TJ) plaque, but might not be an exclusively junctional

component. May have a house-keeping rule. Is involved in pre-mRNA polyadenylation. Enhances SSU72 phosphatase activity

Gene Wiki entry for SYMPK

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011109.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SYMPK gene promoter:
Bach1 USF1 Olf-1 Ik-3 c-Ets-1 AREB6 HEN1 USF-1 ZID
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SYMPK promoter sequence

Search SABiosciences Chromatin IP Primers for SYMPK

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SYMPK

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.3 Ensembl cytogenetic band: 19q13.32 HGNC cytogenetic band: 19q13.3

SYMPK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SYMPK gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M046318: view genomic region (about GC identifiers)

Start:	46,318,693 bp from pter	End:	46,366,548 bp from pter
Size:	47,856 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SYMPK_HUMAN, Q92797 (See protein sequence)

Recommended Name: Symplekin

Size: 1274 amino acids; 141148 Da

Subunit: Found in a heat-sensitive complex at least composed of several cleavage and polyadenylation specific and

cleavage stimulation factors. Interacts with CPSF2, CPSF3 and CSTF2. Interacts with HSF1 in heat-stressed cells.

Interacts with SSU72

Subcellular location: Cytoplasm, cytoskeleton. Cell junction, tight junction. Cell membrane; Peripheral membrane

protein; Cytoplasmic side. Cell junction. Nucleus, nucleoplasm. Note=Cytoplasmic face of adhesion plaques (major) and

nucleoplasm (minor) (in cells with TJ). Nucleoplasm (in cells without TJ). Nuclear bodies of heat-stressed cells

Miscellaneous: Could be used as a differentiation marker in the differential diagnosis of tumors

Sequence caution: Sequence=AAC50667.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Sequence=AAH30214.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;

Sequence=BAD92261.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=CAA71861.1;

Type=Frameshift; Positions=67;

6/7 PDB 3D structures from and Proteopedia for SYMPK (see all 7):

3O2Q (3D)

3O2S (3D)

3O2T (3D)

3ODR (3D)

3ODS (3D)

4H3H (3D)

Secondary accessions: O00521 O00689 O00733 Q59GT5 Q8N2U5

Alternative splicing: 2 isoforms: Q92797-1 Q92797-2 (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SYMPK: NX_Q92797

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q92797

SYMPK Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_004810.2

ENSEMBL proteins:

ENSP00000245934

Human Recombinant Protein Products:

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	Novus Biologicals SYMPK Protein Novus Biologicals SYMPK Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SYMPK

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--
GO:0005654	nucleoplasm	IDA	8769423
GO:0005730	NOT nucleolus	IDA	--
GO:0005737	cytoplasm	IDA	--
GO:0005856	cytoskeleton	IEA	--

SYMPK for ontologies About GeneDecksing

SYMPK Antibody Products:

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	Uscn Antibodies for SYMPK
	Search ThermoFisher Antibodies for SYMPK

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	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for SYMPK

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SYMPK for domains About GeneDecksing

4 InterPro domains/families:

IPR011989 ARM-like

IPR022075 Symplekin_C

IPR021850 DUF3453

IPR016024 ARM-type_fold

Graphical View of Domain Structure for InterPro Entry Q92797

ProtoNet protein and cluster: Q92797

1 Blocks protein family: IPB000357 HEAT repeat

UniProtKB/Swiss-Prot: SYMPK_HUMAN, Q92797

Domain: The HEAT repeats have been determined based on 3D-structure analysis of the D.melanogaster ortholog and are not

detected by sequence-based prediction programs

Similarity: Belongs to the Symplekin family

Similarity: Contains 5 HEAT repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: SYMPK_HUMAN, Q92797

Function: Scaffold protein that functions as a component of a multimolecular complex involved in histone mRNA 3'-end

processing. Specific component of the tight junction (TJ) plaque, but might not be an exclusively junctional

component. May have a house-keeping rule. Is involved in pre-mRNA polyadenylation. Enhances SSU72 phosphatase activity

miRNA Products:		OriGene 3'-UTR Clone: SYMPK Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SYMPK
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate SYMPK
		SwitchGear 3'UTR luciferase reporter plasmid: SYMPK 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SYMPK OriGene shRNA RFP: SYMPK OriGene siRNA: SYMPK
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for SYMPK

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		GenScript: all cDNA clones in your preferred vector: SYMPK (NM_004819)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SYMPK
		Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SYMPK

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SYMPK
		Search LifeMap BioReagents cell lines for SYMPK

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYMPK

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	18688255

SYMPK for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for SYMPK:

Decreased viability with pacli

Animal Models:
1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Sympk):

mortality/aging

SYMPK for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Sertoli-Sertoli Cell Junction Dynamics

Sertoli-Sertoli Cell Junction Dynamics

1.00

Epithelial Tight Junctions

0.36

Chromatin Regulation / Acetylation

Chromatin Regulation / Acetylation

1.00

Tight junction

Tight junction

1.00

mRNA surveillance pathway

mRNA surveillance pathway

1.00

Translational Control

Translational Control

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for SYMPK

	Sertoli-Sertoli Cell Junction Dynamics
	Epithelial Tight Junctions

2 Cell Signaling Technology (CST) Pathways for SYMPK

	Chromatin Regulation / Acetylation
	Translational Control

2 Kegg Pathways (Kegg details for SYMPK):

	mRNA surveillance pathway
	Tight junction

SYMPK for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for SYMPK

STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

5/754 Interacting proteins for SYMPK (Q92797^{2, 3} ENSP00000245934⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 754)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CPSF2	Q9P2I0²^,³, ENSP00000298875⁴	MINT-6802626 MINT-7945693 MINT-8198073 MINT-6802510 MINT-7947479 MINT-6802610 I2D: score=1 STRING: ENSP00000298875
CSTF2	P33240²^,³, ENSP00000362063⁴	MINT-6802510 I2D: score=3 STRING: ENSP00000362063
CPSF3	Q9UKF6², ENSP00000238112⁴	MINT-7945693 MINT-8198073 MINT-6802510 MINT-7947479 MINT-6802610 STRING: ENSP00000238112
PCBP2	Q15366², ENSP00000352438⁴	MINT-7945693 MINT-8198073 MINT-7947479 STRING: ENSP00000352438
CDC73	Q6P1J9², ENSP00000356405⁴	MINT-7945693 MINT-7947479 STRING: ENSP00000356405

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006378	mRNA polyadenylation	IMP	--
GO:0006397	mRNA processing	--	--
GO:0007155	cell adhesion	IEA	--
GO:0008150	biological_process	--	--
GO:0035307	positive regulation of protein dephosphorylation	IDA	--

SYMPK for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

SYMPK for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SYMPK
1 Novoseek chemical compound relationship for SYMPK gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
adenylate	24.1	1	16230528 (1)

Search CenterWatch for drugs/clinical trials and news about SYMPK

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SYMPK gene:

NM_004819.2

Unigene Cluster for SYMPK:

Symplekin

Hs.515475 [show with all ESTs]

Unigene Representative Sequence: AB210010

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000245934(uc002pdn.3 uc002pdo.1 uc002pdp.1 uc002pdq.2)

miRNA Products:		OriGene 3'-UTR Clone: SYMPK Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SYMPK
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		SwitchGear 3'UTR luciferase reporter plasmid: SYMPK 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SYMPK (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SYMPK (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SYMPK (NM_004819)
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Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SYMPK Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SYMPK
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SYMPK

Additional cDNA sequence:

AB210010.1 AF049526.1 AK130602.1 AK300252.1 AL831859.1 BC006536.2 BC006567.2 BC030214.1

U49240.1 U88726.1 Y10931.1

23 DOTS entries:

DT.452017 DT.100754064 DT.100037326 DT.40191674 DT.95278861 DT.100037325 DT.121469918 DT.95072423

DT.91750131 DT.121469878 DT.91948970 DT.97860378 DT.100783806 DT.121469905 DT.91762946 DT.92053277

DT.95127510 DT.100783808 DT.121469864 DT.91762941 DT.97860377 DT.91974827 DT.92007355

24/296 AceView cDNA sequences (see all 296):

BC006536 BC006567 CB217016 CA446599 BU182320 BM457257 F12181 BU196958

AL044661 CK725005 CA390883 BI826767 BG739999 CD243784 BG258290 AL044066

BM693610 CA431136 BE734035 BU178580 BU541637 BU620428 BE535210 Y10931

GeneLoc Exon Structure

5/12 Alternative Splicing Database (ASD) splice patterns (SP) for SYMPK (see all 12) About this scheme

ExUns:	1	^	2a	·	2b	·	2c	^	3	^	4	^	5	^	6a	·	6b	·	6c	^	7	^	8	^	9a	·	9b	^	10a	·	10b	^	11a	·	11b	^	12	^	13a	·	13b	^	14	^	15	^	16	^	17	^	18	^
SP1:			-		-																				-		-														-
SP2:			-		-																				-		-
SP3:
SP4:			-
SP5:

ExUns:	19	^	20	^	21a	·	21b	^	22	^	23	^	24a	·	24b	^	25	^	26a	·	26b	·	26c	^	27	^	28a	·	28b
SP1:			-		-
SP2:
SP3:					-										-				-
SP4:
SP5:			-		-										-

ECgene alternative splicing isoforms for SYMPK

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SYMPK expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GATGACGACT

About this image
See SYMPK Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SYMPK

SOURCE GeneReport for Unigene cluster: Hs.515475

UniProtKB/Swiss-Prot: SYMPK_HUMAN, Q92797

Tissue specificity: In testis, expressed in polar epithelia and Sertoli cells but not in vascular endothelia. The

protein is detected in stomach, duodenum, pancreas, liver, fetal brain, carcinomas, lens-forming cells, fibroblasts,

lymphocytes, lymphoma cells, erythroleukemia cells but not in endothelium of vessels, epidermis, intercalated disks,

Purkinje fiber cells of the heart and lymph node

SABiosciences Expression via Pathway-Focused PCR Arrays including SYMPK:

Tight Junctions in human mouse rat

Huntington's Disease in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SYMPK Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SYMPK

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYMPK

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for SYMPK gene from 8/27 species (see all 27) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Sympk^{1 , 5}	symplekin^{1, 5}	88.43(n)¹ 94.89(a)¹		7 (9.46 cM)⁵ 68188¹ NM_026605.2¹ NP_080881.2¹ 19024377⁵
lizard (Anolis carolinensis)	Reptilia	SYMPK⁶	--	81(a)	1 ↔ 1	GL343962.1(14629-53626)
African clawed frog (Xenopus laevis)	Amphibia	MGC53503²	similar to symplekin; Huntingtin interacting protein more	73.37(n)		BC047265.1
zebrafish (Danio rerio)	Actinopterygii	Dr.4673²	Transcribed sequence with moderate similarity to protein more	81.32(n)		CD759709.1
fruit fly (Drosophila melanogaster)	Insecta	Sym¹	Symplekin	46.95(n) 37.61(a)		40709 NM_141323.1 NP_649580.1
worm (Caenorhabditis elegans)	Secernentea	symk-1¹	Protein SYMK-1	41.39(n) 31.29(a)		182490 NM_072809.4 NP_505210.2
thale cress (Arabidopsis thaliana)	eudicotyledons	ESP4¹	symplekin	40.72(n) 29.59(a)		831597 NM_120218.2 NP_195760.1
rice (Oryza sativa)	Liliopsida	Os07g0693900¹	hypothetical protein	41.37(n) 30.64(a)		4344390 NM_001067269.1 NP_001060734.1

ENSEMBL Gene Tree for SYMPK (if available)
TreeFam Gene Tree for SYMPK (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs201397109^1,2		--	46318435(+)	`CCCATA/GGTTCG`	2	--	ut5¹ ds500¹		0	--	--	--	--
rs114004022^1,2	F,	--	46318563(+)	`GCGGGG/AAGCGG`	2	--	ds500¹ ut5¹		1		WA	118
rs116464103^1,2		--	46318633(+)	`GTGGAC/TGTCGC`	2	--	us2k¹ ds500¹		1		WA	118
rs5828250^1,2	C,F,	--	46318678(+)	`GCCATC/-CCTTT`	2	--	ds500¹ us2k¹		3		NA CSA	6
rs74596352^1,2	C,F	--	46318680(+)	`CATCCT/CTTTTT`	2	--	ds500¹ us2k¹		3		NA WA	8
rs200841014^1,2		--	46318680(+)	`CATCC-/CTTTTTT`	2	--	us2k¹ ds500¹		0	--	--	--	--
rs199630042^1,2		--	46318681(+)	`ATCCC-/TTTTTT`	2	--	ds500¹ us2k¹		0	--	--	--	--
rs3810333^1,2	C,	--	46318691(-)	`AAAAGG/AAAAAA`	2	--	us2k¹ ds500¹		4		NA EA	244
rs140334478^1,2	C,	--	46318759(+)	`TCAAG-/CCCCG CCCCGTCCCCCAG`	2	--	ut3¹ us2k¹		0	--	--	--	--
rs4991330^1,2	C	--	46318762(+)	`AGCCCA/CGCCCC`	2	--	us2k¹ ut3¹ ese³		0	--	--	--	--

HapMap Linkage Disequilibrium report for SYMPK (46318693 - 46366548 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for SYMPK
1 Indel: 73388

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SYMPK for disorders           About GeneDecksing

OMIM gene information: 602388    OMIM disorders: --

7 diseases for SYMPK:    About MalaCards

thoracic outlet syndrome myotonic dystrophy squamous cell carcinoma huntington's disease

crohn's disease hepatocellular carcinoma carcinoma

Human Genome Epidemiology (HuGE) Navigator: SYMPK (1 document)

Export disorders for SYMPK gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SYMPK gene, integrated from 9 sources (see all 51):
(articles sorted by number of sources associating them with SYMPK)

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Chromosomal localization to 19q13.3, partial genomic structure and 5' cDNA sequence of the human symplekin gene. (PubMed id 9330635)^{1, 2, 3} Ueki K.... Louis D.N. (1997)
Symplekin and multiple other polyadenylation factors participate in 3'-end maturation of histone mRNAs. (PubMed id 16230528)^{1, 2, 9} Kolev N.G. and Steitz J.A. (2005)
Complex protein interactions within the human polyadenylation machinery identify a novel component. (PubMed id 10669729)^{1, 2, 9} Takagaki Y. and Manley J.L. (2000)
Symplekin, a novel type of tight junction plaque protein. (PubMed id 8769423)^{1, 2, 9} Keon B.H.... Franke W.W. (1996)
HSF1 modulation of Hsp70 mRNA polyadenylation via interaction with symplekin. (PubMed id 14707147)^{1, 2, 9} Xing H.... Sarge K.D. (2004)
Crystal structure of the human symplekin-Ssu72-CTD ph osphopeptide complex. (PubMed id 20861839)^{1, 2} Xiang K....Tong L. (2010)
Conserved motifs in both CPSF73 and CPSF100 are required to assemble the active endonuclease for histone mRNA 3'-end maturation. (PubMed id 18688255)^{1, 2} Kolev N.G.... Steitz J.A. (2008)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Six transcripts map within 200 kilobases of the myotonic dystrophy expanded repeat. (PubMed id 9585442)^{1, 2} Alwazzan M.... Brook J.D. (1998)
Symplekin promotes tumorigenicity by up-regulating cl audin-2 expression. (PubMed id 20133805)^{1, 9} Buchert M....Hollande F. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 8189	HGNC: 22935	AceView: SYMPK	Ensembl:ENSG00000125755	euGenes: HUgn8189
ECgene: SYMPK	Kegg: 8189	H-InvDB: SYMPK

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SYMPK	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SYMPK gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SYMPK gene:
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GeneCards and IP:
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