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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SYK Gene

protein-coding   GIFtS: 73
GCID: GC09P093564

spleen tyrosine kinase
 Explore 74 diseases affiliated with
SYK via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SYK    

Aliases
for SYK gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Spleen Tyrosine Kinase1 2 3
P72-Syk1
EC 2.7.10.23 8
Tyrosine-Protein Kinase SYK2
EC 2.7.108

External Ids:    HGNC: 114911   Entrez Gene: 68502   Ensembl: ENSG000001650257   OMIM: 6000855   UniProtKB: P434053   

Export aliases for SYK gene to outside databases

Previous GC identifers: GC09P084403 GC09P085292 GC09P086863 GC09P088905 GC09P090643 GC09P092603 GC09P063244


Summaries
for SYK gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SYK:
This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in
hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate
diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a
modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively
spliced transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Mar 2010)

UniProtKB/Swiss-Prot: KSYK_HUMAN, P43405
Function: Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane
receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes
including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular
development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction
between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the receptor can
also be indirect and mediated by adapter proteins containing ITAM or partial hemITAM domains. The phosphorylation of
the ITAM domains is generally mediated by SRC subfamily kinases upon engagement of the receptor. More rarely signal
transduction via SYK could be ITAM-independent. Direct downstream effectors phosphorylated by SYK include VAV1, PLCG1,
PI-3-kinase, LCP2 and BLNK. Initially identified as essential in B-cell receptor (BCR) signaling, it is necessary for
the maturation of B-cells most probably at the pro-B to pre-B transition. Activated upon BCR engagement, it
phosphorylates and activates BLNK an adapter linking the activated BCR to downstream signaling adapters and effectors.
It also phosphorylates and activates PLCG1 and the PKC signaling pathway. It also phosphorylates BTK and regulates its
activity in B-cell antigen receptor (BCR)-coupled signaling. Beside its function downstream of BCR plays also a role
in T-cell receptor signaling. Plays also a crucial role in the innate immune response to fungal, bacterial and viral
pathogens. It is for instance activated by the membrane lectin CLEC7A. Upon stimulation by fungal proteins, CLEC7A
together with SYK activates immune cells inducing the production of ROS. Also activates the inflammasome and
NF-kappa-B-mediated transcription of chemokines and cytokines in presence of pathogens. Regulates neutrophil
degranulation and phagocytosis through activation of the MAPK signaling cascade. Also mediates the activation of
dendritic cells by cell necrosis stimuli. Also involved in mast cells activation. Also functions downstream of
receptors mediating cell adhesion. Relays for instance, integrin-mediated neutrophils and macrophages activation and
P-selectin receptor/SELPG-mediated recruitment of leukocytes to inflammatory loci. Plays also a role in non-immune
processes. It is for instance involved in vascular development where it may regulate blood and lymphatic vascular
separation. It is also required for osteoclast development and function. Functions in the activation of platelets by
collagen, mediating PLCG2 phosphorylation and activation. May be coupled to the collagen receptor by the ITAM
domain-containing FCER1G. Also activated by the membrane lectin CLEC1B that is required for activation of platelets by
PDPN/podoplanin. Involved in platelet adhesion being activated by ITGB3 engaged by fibrinogen

summary for SYK:
Spleen tyrosine kinase (Syk) is a non-receptor cytoplasmic enzyme that is primarily expressed in cells of
hematopoietic lineage. Syk contains two adjacent SH2 domains that bind to immunoreceptor tyrosine-based
activation motifs (ITAMs) to activate and autophosphorylate the enzyme. This allows Syk to phosphorylate its
specific substrates including other enzymes and adaptor proteins, orchestrating a complex series of cellular
responses such as cell proliferation, differentiation, survival and phagocytosis. Recently, Syk has been
found to be expressed in a variety of other cells including fibroblasts (where it mediates adipogenesis),
epithelial cells (where it controls cell division and acts as a tumor suppressor), hepatocytes (where it is
involved in ERK activation) and neuronal cells (where it is involved in neuronal differentiation).

Gene Wiki entry for SYK (Syk)


Genomic Views
for SYK gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.1  NT_008470.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SYK gene promoter:
         AhR   STAT1   p53   AP-1   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SYK promoter sequence
   Search SABiosciences Chromatin IP Primers for SYK

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SYK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q22   Ensembl cytogenetic band:  9q22.2   HGNC cytogenetic band: 9q22

SYK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SYK gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P093564:  view genomic region     (about GC identifiers)

Start:
 93,564,012 bp from pter      End:
 93,660,842 bp from pter
Size:
 96,831 bases      Orientation:
 plus strand

Proteins
for SYK gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: KSYK_HUMAN, P43405 (See protein sequence)
Recommended Name: Tyrosine-protein kinase SYK  
Size: 635 amino acids; 72066 Da
Subunit: Interacts with LYN; phosphorylates SYK (By similarity). Interacts with RHOH (phosphorylated); regulates mast
cells activation (By similarity). Interacts with NFAM1 (phosphorylated); probably involved in BCR signaling (By
similarity). Interacts with VAV1 (via SH2 domain); phosphorylates VAV1 upon BCR activation. Interacts with GAB2
(phosphorylated); probably involved in IgE Fc receptor signaling (By similarity). Interacts (via its SH2 domains) with
CD79A (via its phosphorylated ITAM domain); the interaction stimulates SYK autophosphorylation and activation (By
similarity). Interacts with FCRL3. Interacts (via SH2 domains) with FCER1G (via ITAM domain); activates SYK and
mediates neutrophils and macrophages integrin-mediated activation (By similarity). Interacts with ITGB2 and FGR;
involved in ITGB2 downstream signaling (By similarity). Interacts with ITGB3; upon activation by ITGB3 promotes
platelet adhesion. Interacts (via SH2 domains) with TYROBP (via ITAM domain); involved in neutrophils and macrophages
integrin-mediated activation (By similarity). Interacts with MSN and SELPLG; mediates the selectin-dependent
activation of SYK by SELPLG. Interacts with BLNK (via SH2 domain). Interacts (via the second SH2 domain) with USP25
(via C-terminus); phosphorylates USP25 and regulates USP25 intracellular levels. Interacts (via SH2 domains) with
CLEC1B (dimer). Interacts with CLEC7A; participates in leukocyte activation in presence of fungal pathogens. Interacts
(phosphorylated) with SLA; may regulate SYK through CBL recruitment. Interacts with YWHAG; attenuates BCR-induced
membrane translocation and activation of SYK. Interacts with Epstein-Barr virus LMP2A
Subcellular location: Cell membrane (Probable). Cytoplasm, cytosol (Probable)
6/26 PDB 3D structures from and Proteopedia for SYK (see all 26):
1A81 (3D)        1CSY (3D)        1CSZ (3D)        1XBA (3D)        1XBB (3D)        1XBC (3D)    
Alternative splicing: 2 isoforms:  P43405-1   P43405-2   

Explore the universe of human proteins at neXtProt for SYK: NX_P43405

Post-translational modifications:

  • Ubiquitinated by CBLB after BCR activation; which promotes proteasomal degradation (By similarity)1
  • Autophosphorylated. Phosphorylated on tyrosine residues by LYN following receptors engagement. Phosphorylation on
    • Tyr-323 creates a binding site for CBL, an adapter protein that serves as a negative regulator of BCR-stimulated
    calcium ion signaling. Phosphorylation at Tyr-348 creates a binding site for VAV1. Phosphorylation on Tyr-348 and
    Tyr-352 enhances the phosphorylation and activation of phospholipase C-gamma and the early phase of calcium ion
    mobilization via a phosphoinositide 3-kinase-independent pathway (By similarity). Phosphorylation on Ser-297 is very
    common, it peaks 5 minutes after BCR stimulation, and creates a binding site for YWHAG. Phosphorylation at Tyr-630
    creates a binding site for BLNK. Dephosphorylated by PTPN61
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P43405

    • 4/19 DME Specific Peptides for SYK (P43405) (see all 19)
     RDLAARN  FVHRDLA  AARNVLL  SYGQKPY 

    SYK Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001128524.1  NP_001167638.1  NP_001167639.1  NP_003168.2  

    ENSEMBL proteins: 
     ENSP00000364907   ENSP00000364904   ENSP00000364899   ENSP00000364898  
    Reactome Protein details: P43405
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant SYK Protein
    R&D Systems Recombinant & Natural Proteins for SYK
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: SYK
    OriGene Protein Over-expression Lysate: SYK
    OriGene Custom Protein Services for SYK 
    GenScript Custom Purified and Recombinant Proteins Services for SYK
    Novus Biologicals SYK Proteins
    Novus Biologicals SYK Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for SYK
    Uscn Proteins for SYK

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--
    GO:0019815B cell receptor complex IEA--
    GO:0032009early phagosome ISS--


    SYK for ontologies           About GeneDecksing



    SYK Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of SYK
    R&D Systems Antibodies for SYK
    Cell Signaling Technology (CST) Antibodies for SYK 
    OriGene Antibodies (see all 5): SYK
    OriGene Custom Antibody Services for SYK 
    GenScript Superior Antibodies for SYK
    Novus Biologicals SYK Antibodies
    Abcam antibodies for SYK 
    Uscn Antibodies for SYK
    ThermoFisher Antibody for SYK

    Assay Products for SYK: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SYK
    Cell Signaling Technology (CST) Sandwich ELISA Kits for SYK
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for SYK

    Protein Domains /
    Families
    for SYK gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SYK for domains           About GeneDecksing

    5/9 InterPro domains/families (see all 9):
     IPR012234 Tyr_kinase_non-rcpt_SYK/ZAP70
     IPR017441 Protein_kinase_ATP_BS
     IPR001245 Ser-Thr/Tyr_kinase_cat_dom
     IPR011009 Kinase-like_dom
     IPR000980 SH2

    Graphical View of Domain Structure for InterPro Entry P43405

    ProtoNet protein and cluster: P43405

    2 Blocks protein families:
    IPB000980 SH2 domain signature
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: KSYK_HUMAN, P43405
    Domain: The SH2 domains mediate the interaction of SYK with the phosphorylated ITAM domains of transmembrane proteins.
    Some proteins like CLEC1B have a partial ITAM domain (also called hemITAM) containing a single YxxL motif. The
    interaction with SYK requires CLEC1B homodimerization
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. SYK/ZAP-70 subfamily
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 2 SH2 domains


    Function
    for SYK gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: KSYK_HUMAN, P43405
    Function: Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane
    receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes
    including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular
    development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction
    between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the receptor can
    also be indirect and mediated by adapter proteins containing ITAM or partial hemITAM domains. The phosphorylation of
    the ITAM domains is generally mediated by SRC subfamily kinases upon engagement of the receptor. More rarely signal
    transduction via SYK could be ITAM-independent. Direct downstream effectors phosphorylated by SYK include VAV1, PLCG1,
    PI-3-kinase, LCP2 and BLNK. Initially identified as essential in B-cell receptor (BCR) signaling, it is necessary for
    the maturation of B-cells most probably at the pro-B to pre-B transition. Activated upon BCR engagement, it
    phosphorylates and activates BLNK an adapter linking the activated BCR to downstream signaling adapters and effectors.
    It also phosphorylates and activates PLCG1 and the PKC signaling pathway. It also phosphorylates BTK and regulates its
    activity in B-cell antigen receptor (BCR)-coupled signaling. Beside its function downstream of BCR plays also a role
    in T-cell receptor signaling. Plays also a crucial role in the innate immune response to fungal, bacterial and viral
    pathogens. It is for instance activated by the membrane lectin CLEC7A. Upon stimulation by fungal proteins, CLEC7A
    together with SYK activates immune cells inducing the production of ROS. Also activates the inflammasome and
    NF-kappa-B-mediated transcription of chemokines and cytokines in presence of pathogens. Regulates neutrophil
    degranulation and phagocytosis through activation of the MAPK signaling cascade. Also mediates the activation of
    dendritic cells by cell necrosis stimuli. Also involved in mast cells activation. Also functions downstream of
    receptors mediating cell adhesion. Relays for instance, integrin-mediated neutrophils and macrophages activation and
    P-selectin receptor/SELPG-mediated recruitment of leukocytes to inflammatory loci. Plays also a role in non-immune
    processes. It is for instance involved in vascular development where it may regulate blood and lymphatic vascular
    separation. It is also required for osteoclast development and function. Functions in the activation of platelets by
    collagen, mediating PLCG2 phosphorylation and activation. May be coupled to the collagen receptor by the ITAM
    domain-containing FCER1G. Also activated by the membrane lectin CLEC1B that is required for activation of platelets by
    PDPN/podoplanin. Involved in platelet adhesion being activated by ITGB3 engaged by fibrinogen
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
    Enzyme regulation: Autoinhibited. Intramolecular binding of the interdomains A and B (also called linker region) to
    parts of the catalytic domain keep the catalytic center in an inactive conformation. The phosphorylation of the
    interdomains or the binding of the SH2 domains with dually phosphorylated ITAM domains on transmembrane proteins
    disrupt those intramolecular interactions allowing the kinase domain to adopt an active conformation. The
    phosphorylation of SYK and of the ITAM domains which is responsible for SYK activation is essentially mediated by SRC
    subfamily kinases, like LYN, upon transmembrane receptors engagement. May also be negatively regulated by PTPN6
    through dephosphorylation. Downstream signaling adapters and intermediates like BLNK or RHOH may mediate positive
    and/or negative feedback regulation. Negatively regulated by CBL and CBLB through ubiquitination and probable
    degradation. Phosphorylates SH3BP2 which in turn may regulate SYK through LYN (By similarity)

         Genatlas biochemistry entry for SYK:
    spleen tyrosine kinase,non SRC family,expressed in B,T and myeloid cells

    Enzyme Numbers (IUBMB): EC 2.7.10.21 2 EC 2.7.102

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 2): SYK
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SYK
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate SYK:
    hsa-miR-767-3p hsa-miR-2276 hsa-miR-4290 hsa-miR-497* hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmid: SYK 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SYK (see all 7)
    OriGene shRNA RFP: SYK
    OriGene siRNA: SYK
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SYK

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SYK

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SYK (see all 6)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SYK (see all 5)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 4): SYK (NM_003177)
    Sino Biological Human cDNA Clone for SYK
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SYK
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYK 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for SYK
    Search LifeMap BioReagents cell lines for SYK

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYK

    Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity NAS12885943
    GO:0004713protein tyrosine kinase activity ----
    GO:0004715non-membrane spanning protein tyrosine kinase activity TAS--
    GO:0004716receptor signaling protein tyrosine kinase activity IEA--
    GO:0005178integrin binding IPI12885943


    SYK for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for SYK:
     Decreased substrate adherent c  Upregulation of Wnt/beta-caten 

    Animal Models:
         Mouse knock-outs for SYK: Syktm1.1Tara Syktm1Tyb Syktm1Paw
         13 MGI mutant phenotypes (inferred from 9 alleles) (MGI details for Syk):
     cardiovascular system  cellular  hematopoietic system  homeostasis/metabolism  immune system 
     limbs/digits/tail  liver/biliary system  mortality/aging  nervous system  no phenotypic analysis 
     renal/urinary system  respiratory system  skeleton 

    SYK for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SYK gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/51 super-pathways (see all 51) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Immune response CD16 signaling in NK cells
    		Immune response CD16 signaling in NK cells1.00
    		Immune response_Role of DAP12 receptors in NK cells0.32
    		Immune response_CD16 signaling in NK cells0.99
    		Immune response Role of DAP12 receptors in NK cells0.32
    2Immune response Fc epsilon RI pathway
    		Immune response Fc epsilon RI pathway1.00
    		Fc-epsilon receptor I signaling in mast cells0.33
    		Immune response_Fc epsilon RI pathway0.99
    3Immune System
    		Immune System1.00
    		Innate Immune System0.46
    		Adaptive Immune System0.59
    4B cell receptor signaling pathway
    		B cell receptor signaling pathway1.00
    		PI3K Signaling in B-Lymphocyte0.35
    		BCR signaling pathway0.41
    5Interleukin receptor SHC signaling
    		Interleukin-2 signaling0.67
    		Signaling by Interleukins0.25
    		Interleukin-3, 5 and GM-CSF signaling0.57

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/8 EMD Millipore Pathways for SYK (see all 8)
        Immune response BCR pathway
    Immune response CD16 signaling in NK cells
    Immune response Role of DAP12 receptors in NK cells
    Signal transduction IP3 signaling
    Development EPO-induced MAPK pathway

    5/15 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for SYK (see all 15)
        Fc-Gamma-RIIB Signaling in B-Cells
    Fc-GammaR Pathway
    TREM1 Pathway
    PI3K Signaling in B-Lymphocyte
    CD28 Signaling in T-Helper Cell

    2 Cell Signaling Technology (CST) Pathways for SYK
        Lymphocyte Signaling
    Tyrosine Kinases / Adaptors

    5/8 GeneGo (Thomson Reuters) Pathways for SYK (see all 8)
        Development EPO-induced MAPK pathway
    Immune response CD16 signaling in NK cells
    Immune response BCR pathway
    Immune response IL-2 activation and signaling pathway
    Immune response NFAT in immune response

    5/13 BioSystems Pathways for SYK (see all 13) 
        IL-5 Signaling Pathway
    IL-2 Signaling Pathway
    IL-3 Signaling Pathway
    RANKL/RANK Signaling Pathway
    B Cell Receptor Signaling Pathway

    5/27        Reactome Pathways for SYK (see all 27)
        FCGR activation
    Regulation of signaling by CBL
    CBL ubiquitinates PI3K
    GPVI stimulates PI3K beta, gamma
    DAP12 interactions


    5/6         Kegg Pathways  (Kegg details for SYK) (see all 6):
        Osteoclast differentiation
    Natural killer cell mediated cytotoxicity
    B cell receptor signaling pathway
    Fc epsilon RI signaling pathway
    Fc gamma R-mediated phagocytosis


    SYK for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SYK

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/222 Interacting proteins for SYK (P434051, 2, 3 ENSP000003648984) via UniProtKB, MINT, STRING, and/or I2D (see all 222)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CBLP226812, 3, ENSP000002640334MINT-50721 MINT-50719 MINT-6538977 MINT-50720 MINT-50715 MINT-6539663 MINT-7301412 MINT-17273 I2D: score=6 STRING: ENSP00000264033
    LCKP062392, 3, ENSP000003378254MINT-8036452 MINT-8036467 MINT-16945 MINT-8033612 MINT-56730 MINT-8036437 MINT-8033582 MINT-8033597 I2D: score=4 STRING: ENSP00000337825
    ERBB2P046262, 3, ENSP000002695714MINT-74765 MINT-74767 MINT-74769 MINT-74758 MINT-74768 MINT-74764 MINT-74766 I2D: score=2 STRING: ENSP00000269571
    CD3EP077662, 3, ENSP000003545664MINT-8035866 MINT-8031546 MINT-8031561 MINT-8031530 MINT-8035897 MINT-8035882 I2D: score=4 STRING: ENSP00000354566
    EGFRP005332, 3, ENSP000002754934MINT-74761 MINT-74757 MINT-74759 MINT-74760 MINT-74762 MINT-74763 I2D: score=2 STRING: ENSP00000275493
    About this table

    Gene Ontology (GO): 5/53 biological process terms (GO ID links to tree view) (see all 53):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000187activation of MAPK activity ----
    GO:0001525angiogenesis IEA--
    GO:0001820serotonin secretion ----
    GO:0001945lymph vessel development ISS--
    GO:0002250adaptive immune response ISS--


    SYK for ontologies           About GeneDecksing



    Drugs & Compounds
    for SYK gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SYK for compounds           About GeneDecksing

    EMD Millipore small molecules for SYK:
    Small Molecule - inhibitor
    Enzo Life Sciences drugs & compounds for SYK

    Compounds for SYK available from Tocris Bioscience    About this table
    CompoundAction CAS #
    ER 27319 maleateSelective Syk kinase inhibitor[201010-95-9]
    PiceatannolInhibits TNF-induced NF-kappaB activation[10083-24-6]
    MNSSelective inhibitor of Src and Syk[1485-00-3]

    3 HMDB Compounds for SYK    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    CalciumCa (see all 2)7440-70-2--

    5 DrugBank Compounds for SYK    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Staurosporine-- 62996-74-1target--17139284 17016423
    2-{2-[(3,5-dimethylphenyl)amino]pyrimidin-4-yl}-N-[(1S)-2-hydroxy-1-methylethyl]-4-methyl-1,3-thiazole-5-carboxamide-- --target--10592235
    2-{[(1R,2S)-2-aminocyclohexyl]amino}-4-[(3-methylphenyl)amino]pyrimidine-5-carboxamide-- --target--10592235
    6-({5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]pyrimidin-4-yl}amino)-2,2-dimethyl-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one-- --target--10592235
    N-(2-hydroxy-1,1-dimethylethyl)-1-methyl-3-(1H-pyrrolo[2,3-b]pyridin-2-yl)-1H-indole-5-carboxamide-- --target--10592235

    10/74 Novoseek chemical compound relationships for SYK gene (see all 74)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    piceatannol 93.2 94 10194444 (4), 10586078 (4), 15123770 (2), 12393431 (2) (see all 50)
    tyrosine 90.8 1368 9186005 (6), 10931839 (6), 7538118 (6), 9208937 (5) (see all 99)
    convulxin 76.2 8 9670039 (2), 10217417 (1), 10942756 (1), 11278467 (1) (see all 6)
    phosphotyrosine 69.1 11 8590001 (1), 10075687 (1), 18689684 (1), 19421152 (1) (see all 11)
    pp55 67.3 1 9195899 (1)
    4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine 64.7 4 14978183 (1), 15107458 (1), 19797620 (1)
    phosphatidylinositol 62.2 25 12477728 (5), 11698498 (3), 9183664 (1), 7831290 (1) (see all 18)
    wortmannin 53.2 7 10586078 (2), 11698498 (1), 16918505 (1), 14699155 (1) (see all 5)
    bis(maltolato)oxovanadium(iv) 52.2 1 7657667 (1)
    phosphoinositide 51.3 14 11331248 (1), 20367574 (1), 12077122 (1), 11907067 (1) (see all 13)

    Search CenterWatch for drugs/clinical trials and news about SYK / KSYK 

    Transcripts
    for SYK gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SYK gene (4 alternative transcripts): 
    NM_001135052.2  NM_001174167.1  NM_001174168.1  NM_003177.5  

    Unigene Cluster for SYK:

    Spleen tyrosine kinase
    Hs.371720  [show with all ESTs]
    Unigene Representative Sequence: NM_003177
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000375754(uc004aqz.3) ENST00000375751(uc004ara.3) ENST00000375747(uc004arb.3)
    ENST00000476708 ENST00000375746(uc004arc.3 uc011ltt.2 uc011ltr.2 uc011lts.2)


    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 2): SYK
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    5 QIAGEN miScript miRNA Assays for microRNAs that regulate SYK:
    hsa-miR-767-3p hsa-miR-2276 hsa-miR-4290 hsa-miR-497* hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmid: SYK 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SYK (see all 7)
    OriGene shRNA RFP: SYK
    OriGene siRNA: SYK
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SYK
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 4): SYK (NM_003177)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SYK
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYK 
    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SYK

    Additional cDNA sequence: 

    AJ420449.1 AK057772.1 AK075020.1 AK290927.1 BC001645.2 BC002962.1 BC011399.1 FN391891.1 
    FN391892.1 FN391893.1 L28824.1 S80267.1 X73568.1 Z29630.1 

    19 DOTS entries:

    DT.113736  DT.100775429  DT.100775428  DT.100736526  DT.86850732  DT.100775425  DT.95161192  DT.87016326 
    DT.95212498  DT.100743088  DT.100651169  DT.100739866  DT.121160422  DT.91994386  DT.95161189  DT.95161195 
    DT.100026638  DT.97815100  DT.91768282 

    24/315 AceView cDNA sequences (see all 315):

    CB177901 AA486583 BX363732 BM475950 BF334860 BX482304 AI871668 T48751 
    AA826096 BM542806 CD245195 AA552029 AW518156 W33093 BC011399 AA872010 
    AA279637 BI908048 BU753966 AW086131 T92606 BG315206 AA771697 CF136975 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for SYK (see all 10)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a ·
    SP1:                                                        -                                         -                                                         
    SP2:        -     -     -     -     -                       -                                         -                                                         
    SP3:        -     -     -     -     -                       -                                   -     -                                                         
    SP4:                    -     -     -                       -                                   -     -                                                         
    SP5:                                                        -           -     -     -     -     -     -     -     -                                             

    ExUns: 17b · 17c ^ 18
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for SYK

    Expression
    for SYK gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SYK expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGACTGATCC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SYK expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    4 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Skeletal MuscleHyoid Arch MusclesMononuclear MyocytesSkeletal Muscle
    Skeletal MuscleHyoid Arch MusclesMyoblastsSkeletal Muscle
    Skeletal MuscleMandibular Arch MusclesMononuclear MyocytesSkeletal Muscle
    Skeletal MuscleMandibular Arch MusclesMyoblastsSkeletal Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SYK Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SYK

    SOURCE GeneReport for Unigene cluster: Hs.371720

    UniProtKB/Swiss-Prot: KSYK_HUMAN, P43405
    Tissue specificity: Widely expressed in hematopoietic cells (at protein level). Within the B-cells compartment it is
    for instance expressed for pro-B-cells to plasma cells

        SABiosciences Expression via Pathway-Focused PCR Arrays including SYK: 
              Th17 Response in human mouse rat
              Lymphoma in human mouse rat
              Antifungal Response in human mouse rat
              Tumor Metastasis in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYK

    Orthologs
    for SYK gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for SYK gene from 5/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SYK1 spleen tyrosine kinase 72.76(n)
    80.56(a)    		   427272  NM_001031430.1  NP_001026601.1 
    lizard
    (Anolis carolinensis)    		 Reptilia SYK6
    		 --
    		 75(a)
    		 1 ↔ 1
    		 2(32083568-32121042)
    African clawed frog
    (Xenopus laevis)    		 Amphibia MGC687542 hypothetical protein MGC68754 72.87(n)    BC061936.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii syk1 spleen tyrosine kinase 67.3(n)
    71.55(a)    		   405769  NM_212843.1  NP_998008.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta shark6
    		 SH2 ankyrin repeat kinase
    		 20(a)
    		 possible ortholog
    		 2R(12086931-12090388)


    ENSEMBL Gene Tree for SYK (if available)
    TreeFam Gene Tree for SYK (if available) 

    Paralogs
    for SYK gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SYK gene
    TNK12  JAK22  JAK32  TNK22  TYK22  ERBB42  JAK12  ERBB32  
    PTK22  ERBB22  ZAP702  EGFR2  PTK2B2  
    4 SIMAP similar genes for SYK using alignment to 3 protein entries:     KSYK_HUMAN (see all proteins):
    p72syk    ZAP70    EPHA2    PTPN11

    SYK for paralogs           About GeneDecksing



    Genomic Variants
    for SYK gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2347 NCBI SNPs in SYK are shown (see all 2347)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 9 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1827194561,2
    		--93562069(+) GCTAGA/GCATGG 2 -- us2k10--------
    rs1874247761,2
    		--93562091(+) TGTAAA/TCCCAG 2 -- us2k10--------
    rs1927558851,2
    		--93562127(+) ATCACA/GAGGTC 2 -- us2k10--------
    rs1419450751,2
    		--93562141(+) AGATCA/GAGACC 2 -- us2k10--------
    rs1836936151,2
    		--93562872(+) CCATTC/TATACA 3 -- us2k10--------
    rs2909881,2
    		C,F,A,H,--93562955(-) AATTGG/CAGGTA 3 -- us2k111Minor allele frequency- C:0.45NS NA WA EA 492
    rs1389370011,2
    		--93562969(+) GTATGC/TCACTT 3 -- us2k10--------
    rs1889878281,2
    		--93562972(+) TGTCAC/TTTCCC 3 -- us2k10--------
    rs756746731,2
    		F,--93563060(+) CCATTC/TGCAAA 3 -- us2k11Minor allele frequency- T:0.03WA 118
    rs123492691,2
    		--93563265(+) TATATA/TTTTTT 3 -- us2k12Minor allele frequency- T:0.24CSA WA 119

    HapMap Linkage Disequilibrium report for SYK (93564012 - 93660842 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for SYK
         3 CNVs: 70766 6694 6695
         1 Indel: 60758

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SYK
    DNA2.0 Custom Variant and Variant Library Synthesis for SYK

    Disorders / Diseases
    for SYK gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SYK for disorders           About GeneDecksing

    OMIM gene information: 600085    OMIM disorders: --

    20/74 diseases for SYK (see all 74):    About MalaCards
    zap-70 deficiency    breast carcinoma    splenic marginal zone lymphoma    wiskott-aldrich syndrome
    diffuse large b-cell lymphoma    carcinoma    human t-cell leukemia virus type 1    b-cell lymphomas
    non-hodgkin lymphoma    allergic rhinitis    squamous cell carcinoma    lupus erythematosus
    burkitt's lymphoma    leukemia/lymphoma    oral squamous cell carcinoma    mantle cell lymphoma
    lymphoblastic leukemia    squamous cell carcinoma of the head and neck    leukemia    systemic lupus erythematosus

    5 diseases from the University of Copenhagen DISEASES database for SYK:
    Leukemia     Lymphoma     Arthritis     Cherubism
    Asthma

    10/50 Novoseek disease relationships for SYK gene (see all 50)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia lymphocytic chronic 49.7 5 19549911 (1), 19092849 (1), 19965662 (1), 20335218 (1) (see all 5)
    lymphoma b-cell 42.2 9 16912221 (1), 19092849 (1), 19296913 (1), 19965662 (1) (see all 7)
    lymphocytic leukemia chronic b-cell 41.1 6 16912221 (1), 19092849 (1), 19296913 (1), 19144411 (1)
    leukemia b-cell 37.4 2 16912221 (1), 19092849 (1)
    wiskott-aldrich syndrome 34.5 2 16460447 (1), 11313252 (1)
    leukemia basophilic 32.9 3 7513161 (1), 12193692 (1), 14996825 (1)
    lymphoma t-cell peripheral 32.4 1 16341044 (1)
    autoimmune diseases 31.2 13 15212616 (2), 19220318 (1), 17662659 (1), 20013945 (1) (see all 8)
    rheumatoid arthritis 29.9 8 17537677 (2), 18447591 (1), 19530990 (1), 20001666 (1) (see all 6)
    lymphoma 29.8 21 17182546 (5), 20133729 (3), 16670274 (2), 9565626 (1) (see all 10)

    Human Genome Epidemiology (HuGE) Navigator: SYK (3 documents)

    Export disorders for SYK gene to outside databases

    Publications
    for SYK gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SYK gene, integrated from 9 sources (see all 890):
    (articles sorted by number of sources associating them with SYK)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular mechanism of the Syk activation switch. (PubMed id 18818202)1, 2, 9 Tsang E....Bradshaw J.M. (2008)
    2. Phospholipase C-gamma1 interacts with conserved phosphotyrosyl residues in the linker region of Syk and is a substrate for Syk. (PubMed id 8657103)1, 2, 9 Law C.L....Clark E.A. (1996)
    3. Coordinated regulation of the tyrosine phosphorylation of Cbl by Fyn and Syk tyrosine kinases. (PubMed id 9535867)1, 2, 9 Deckert M.... Liu Y.C. (1998)
    4. Molecular cloning of human Syk. A B cell protein-tyrosine kinase associated with the surface immunoglobulin M-B cell receptor complex. (PubMed id 8163536)1, 2, 9 Law C.-L.... Clark E.A. (1994)
    5. Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton. (PubMed id 11940607)1, 2, 9 Obergfell A....Shattil S.J. (2002)
    6. Structural basis for Syk tyrosine kinase ubiquity in signal transduction pathways revealed by the crystal structure of its regulatory SH2 domains bound to a dually phosphorylated ITAM peptide. (PubMed id 9698567)1, 2, 9 Fuetterer K.... Waksman G. (1998)
    7. Integral membrane protein 2 of Epstein-Barr virus regulates reactivation from latency through dominant negative effects on protein-tyrosine kinases. (PubMed id 7895172)1, 2, 9 Miller C.L.... Kieff E. (1995)
    8. Cloning of the cDNA for the deleted syk kinase homologous to ZAP-70 from human basophilic leukemia cell line (KU812). (PubMed id 7513161)1, 2, 9 Yagi S.... Ra C. (1994)
    9. Association of the Src homology 2 domain-containing leukocyte phosphoprotein of 76 kD (SLP-76) with the p85 subunit of phosphoinositide 3-kinase. (PubMed id 15388330)1, 2, 9 Shim E.K....Lee J.R. (2004)
    10. ITAM-based interaction of ERM proteins with Syk mediates signaling by the leukocyte adhesion receptor PSGL-1. (PubMed id 12387735)1, 2, 9 Urzainqui A....Sanchez-Madrid F. (2002)

    External Searches for SYK gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SYK gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6850 HGNC: 11491 AceView: SYK Ensembl:ENSG00000165025 euGenes: HUgn6850
    ECgene: SYK Kegg: 6850 H-InvDB: SYK

    Other Databases showing SYK gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SYK gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SYK Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SYK Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for SYK gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SYK gene:
    Search GeneIP for patents involving SYK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for SYK gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

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     SYK Proteins, Antibodies, CLIAs, and ELISAs
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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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    von Willebrand factor
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