Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SYK Gene

protein-coding   GIFtS: 76
GCID: GC09P093564

Spleen Tyrosine Kinase

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Spleen Tyrosine Kinase1 2 3
p72-Syk2 3
EC 2.7.10.23 8
Tyrosine-Protein Kinase SYK2
EC 2.7.108

External Ids:    HGNC: 114911   Entrez Gene: 68502   Ensembl: ENSG000001650257   OMIM: 6000855   UniProtKB: P434053   

Export aliases for SYK gene to outside databases

Previous GC identifers: GC09P084403 GC09P085292 GC09P086863 GC09P088905 GC09P090643 GC09P092603 GC09P063244


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for SYK Gene:
This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely
expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling
events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is
thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas.
Alternatively spliced transcript variants encoding different isoforms have been found for this gene. (provided by
RefSeq, Mar 2010)

GeneCards Summary for SYK Gene:
SYK (spleen tyrosine kinase) is a protein-coding gene. Diseases associated with SYK include zap-70 deficiency, and mycobacterium abscessus. GO annotations related to this gene include protein tyrosine kinase activity and protein kinase binding. An important paralog of this gene is TNK1.

UniProtKB/Swiss-Prot: KSYK_HUMAN, P43405
Function: Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane
receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological
processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and
vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via
interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with
the receptor can also be indirect and mediated by adapter proteins containing ITAM or partial hemITAM domains.
The phosphorylation of the ITAM domains is generally mediated by SRC subfamily kinases upon engagement of the
receptor. More rarely signal transduction via SYK could be ITAM-independent. Direct downstream effectors
phosphorylated by SYK include VAV1, PLCG1, PI-3-kinase, LCP2 and BLNK. Initially identified as essential in
B-cell receptor (BCR) signaling, it is necessary for the maturation of B-cells most probably at the pro-B to
pre-B transition. Activated upon BCR engagement, it phosphorylates and activates BLNK an adapter linking the
activated BCR to downstream signaling adapters and effectors. It also phosphorylates and activates PLCG1 and the
PKC signaling pathway. It also phosphorylates BTK and regulates its activity in B-cell antigen receptor
(BCR)-coupled signaling. Beside its function downstream of BCR plays also a role in T-cell receptor signaling.
Plays also a crucial role in the innate immune response to fungal, bacterial and viral pathogens. It is for
instance activated by the membrane lectin CLEC7A. Upon stimulation by fungal proteins, CLEC7A together with SYK
activates immune cells inducing the production of ROS. Also activates the inflammasome and NF-kappa-B-mediated
transcription of chemokines and cytokines in presence of pathogens. Regulates neutrophil degranulation and
phagocytosis through activation of the MAPK signaling cascade. Also mediates the activation of dendritic cells by
cell necrosis stimuli. Also involved in mast cells activation. Also functions downstream of receptors mediating
cell adhesion. Relays for instance, integrin-mediated neutrophils and macrophages activation and P-selectin
receptor/SELPG-mediated recruitment of leukocytes to inflammatory loci. Plays also a role in non-immune
processes. It is for instance involved in vascular development where it may regulate blood and lymphatic vascular
separation. It is also required for osteoclast development and function. Functions in the activation of platelets
by collagen, mediating PLCG2 phosphorylation and activation. May be coupled to the collagen receptor by the ITAM
domain-containing FCER1G. Also activated by the membrane lectin CLEC1B that is required for activation of
platelets by PDPN/podoplanin. Involved in platelet adhesion being activated by ITGB3 engaged by fibrinogen

summary for SYK Gene:
Spleen tyrosine kinase (Syk) is a non-receptor cytoplasmic enzyme that is primarily expressed in cells of
hematopoietic lineage. Syk contains two adjacent SH2 domains that bind to immunoreceptor tyrosine-based
activation motifs (ITAMs) to activate and autophosphorylate the enzyme. This allows Syk to phosphorylate its
specific substrates including other enzymes and adaptor proteins, orchestrating a complex series of cellular
responses such as cell proliferation, differentiation, survival and phagocytosis. Recently, Syk has been
found to be expressed in a variety of other cells including fibroblasts (where it mediates adipogenesis),
epithelial cells (where it controls cell division and acts as a tumor suppressor), hepatocytes (where it is
involved in ERK activation) and neuronal cells (where it is involved in neuronal differentiation).

Gene Wiki entry for SYK (Syk) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000009.12  NT_008470.20  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SYK gene promoter:
         AhR   STAT1   p53   AP-1   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSYK promoter sequence
   Search Chromatin IP Primers for SYK

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SYK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q22   Ensembl cytogenetic band:  9q22.2   HGNC cytogenetic band: 9q22

SYK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SYK gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P093564:  view genomic region     (about GC identifiers)

Start:
93,564,012 bp from pter      End:
93,660,842 bp from pter
Size:
96,831 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: KSYK_HUMAN, P43405 (See protein sequence)
Recommended Name: Tyrosine-protein kinase SYK  
Size: 635 amino acids; 72066 Da
Subunit: Interacts with LYN; phosphorylates SYK (By similarity). Interacts with RHOH (phosphorylated); regulates
mast cells activation (By similarity). Interacts with NFAM1 (phosphorylated); probably involved in BCR signaling
(By similarity). Interacts with VAV1 (via SH2 domain); phosphorylates VAV1 upon BCR activation. Interacts with
GAB2 (phosphorylated); probably involved in IgE Fc receptor signaling (By similarity). Interacts (via its SH2
domains) with CD79A (via its phosphorylated ITAM domain); the interaction stimulates SYK autophosphorylation and
activation (By similarity). Interacts with FCRL3. Interacts (via SH2 domains) with FCER1G (via ITAM domain);
activates SYK and mediates neutrophils and macrophages integrin-mediated activation (By similarity). Interacts
with ITGB2 and FGR; involved in ITGB2 downstream signaling (By similarity). Interacts with ITGB3; upon activation
by ITGB3 promotes platelet adhesion. Interacts (via SH2 domains) with TYROBP (via ITAM domain); involved in
neutrophils and macrophages integrin-mediated activation (By similarity). Interacts with MSN and SELPLG; mediates
the selectin-dependent activation of SYK by SELPLG. Interacts with BLNK (via SH2 domain). Interacts (via the
second SH2 domain) with USP25 (via C-terminus); phosphorylates USP25 and regulates USP25 intracellular levels.
Interacts (via SH2 domains) with CLEC1B (dimer). Interacts with CLEC7A; participates in leukocyte activation in
presence of fungal pathogens. Interacts (phosphorylated) with SLA; may regulate SYK through CBL recruitment.
Interacts with YWHAG; attenuates BCR-induced membrane translocation and activation of SYK. Interacts with
Epstein-Barr virus LMP2A. Interacts (via SH2 domains) with GCSAM; the interaction increases after B-cell receptor
stimulation, resulting in enhanced SYK autophosphorylation and activity
Selected PDB 3D structures from and Proteopedia for SYK (see all 31):
1A81 (3D)        1CSY (3D)        1CSZ (3D)        1XBA (3D)        1XBB (3D)        1XBC (3D)    
Alternative splicing: 2 isoforms:  P43405-1   P43405-2   

Explore the universe of human proteins at neXtProt for SYK: NX_P43405

Explore proteomics data for SYK at MOPED

Post-translational modifications: 

  • Ubiquitinated by CBLB after BCR activation; which promotes proteasomal degradation (By similarity)1
  • Autophosphorylated. Phosphorylated on tyrosine residues by LYN following receptors engagement. Phosphorylation on
    Tyr-323 creates a binding site for CBL, an adapter protein that serves as a negative regulator of BCR-stimulated
    calcium ion signaling. Phosphorylation at Tyr-348 creates a binding site for VAV1. Phosphorylation on Tyr-348 and
    Tyr-352 enhances the phosphorylation and activation of phospholipase C-gamma and the early phase of calcium ion
    mobilization via a phosphoinositide 3-kinase-independent pathway (By similarity). Phosphorylation on Ser-297 is
    very common, it peaks 5 minutes after BCR stimulation, and creates a binding site for YWHAG. Phosphorylation at
    Tyr-630 creates a binding site for BLNK. Dephosphorylated by PTPN61
  • Ubiquitination2 at Lys517
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for SYK (P43405) (see all 19)
     RDLAARN  FVHRDLA  AARNVLL  SYGQKPY 


    See SYK Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001128524.1  NP_001167638.1  NP_001167639.1  NP_003168.2  

    ENSEMBL proteins: 
     ENSP00000364907   ENSP00000364904   ENSP00000364899   ENSP00000364898  
    Reactome Protein details: P43405

    SYK Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant SYK Protein
    R&D Systems Recombinant & Natural Proteins for SYK
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for SYK
    OriGene Protein Over-expression Lysate for SYK
    OriGene MassSpec for SYK
    OriGene Custom Protein Services for SYK
    GenScript Custom Purified and Recombinant Proteins Services for SYK
    Novus Biologicals SYK Proteins
    Novus Biologicals SYK Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for SYK
    Cloud-Clone Corp. Proteins for SYK

    SYK Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of SYK
    R&D Systems Antibodies for SYK
    Cell Signaling Technology (CST) Antibodies for SYK 
    OriGene Antibodies for SYK
    OriGene Custom Antibody Services for SYK
    Novus Biologicals SYK Antibodies
    Abcam antibodies for SYK
    Cloud-Clone Corp. Antibodies for SYK
    ThermoFisher Antibody for SYK
    LSBio Antibodies in human, mouse, rat for SYK

    SYK Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SYK
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SYK
    Cell Signaling Technology (CST) Sandwich ELISA Kits for SYK
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SYK
    Cloud-Clone Corp. CLIAs for SYK


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    SH2D: SH2 domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: spleen tyrosine kinase
    Syk family

    Selected InterPro protein domains (see all 9):
     IPR012234 Tyr_kinase_non-rcpt_SYK/ZAP70
     IPR017441 Protein_kinase_ATP_BS
     IPR001245 Ser-Thr/Tyr_kinase_cat_dom
     IPR011009 Kinase-like_dom
     IPR000980 SH2

    Graphical View of Domain Structure for InterPro Entry P43405

    ProtoNet protein and cluster: P43405

    2 Blocks protein domains:
    IPB000980 SH2 domain signature
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: KSYK_HUMAN, P43405
    Domain: The SH2 domains mediate the interaction of SYK with the phosphorylated ITAM domains of transmembrane
    proteins. Some proteins like CLEC1B have a partial ITAM domain (also called hemITAM) containing a single YxxL
    motif. The interaction with SYK requires CLEC1B homodimerization
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. SYK/ZAP-70 subfamily
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 2 SH2 domains


    SYK for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KSYK_HUMAN, P43405
    Function: Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane
    receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological
    processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and
    vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via
    interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with
    the receptor can also be indirect and mediated by adapter proteins containing ITAM or partial hemITAM domains.
    The phosphorylation of the ITAM domains is generally mediated by SRC subfamily kinases upon engagement of the
    receptor. More rarely signal transduction via SYK could be ITAM-independent. Direct downstream effectors
    phosphorylated by SYK include VAV1, PLCG1, PI-3-kinase, LCP2 and BLNK. Initially identified as essential in
    B-cell receptor (BCR) signaling, it is necessary for the maturation of B-cells most probably at the pro-B to
    pre-B transition. Activated upon BCR engagement, it phosphorylates and activates BLNK an adapter linking the
    activated BCR to downstream signaling adapters and effectors. It also phosphorylates and activates PLCG1 and the
    PKC signaling pathway. It also phosphorylates BTK and regulates its activity in B-cell antigen receptor
    (BCR)-coupled signaling. Beside its function downstream of BCR plays also a role in T-cell receptor signaling.
    Plays also a crucial role in the innate immune response to fungal, bacterial and viral pathogens. It is for
    instance activated by the membrane lectin CLEC7A. Upon stimulation by fungal proteins, CLEC7A together with SYK
    activates immune cells inducing the production of ROS. Also activates the inflammasome and NF-kappa-B-mediated
    transcription of chemokines and cytokines in presence of pathogens. Regulates neutrophil degranulation and
    phagocytosis through activation of the MAPK signaling cascade. Also mediates the activation of dendritic cells by
    cell necrosis stimuli. Also involved in mast cells activation. Also functions downstream of receptors mediating
    cell adhesion. Relays for instance, integrin-mediated neutrophils and macrophages activation and P-selectin
    receptor/SELPG-mediated recruitment of leukocytes to inflammatory loci. Plays also a role in non-immune
    processes. It is for instance involved in vascular development where it may regulate blood and lymphatic vascular
    separation. It is also required for osteoclast development and function. Functions in the activation of platelets
    by collagen, mediating PLCG2 phosphorylation and activation. May be coupled to the collagen receptor by the ITAM
    domain-containing FCER1G. Also activated by the membrane lectin CLEC1B that is required for activation of
    platelets by PDPN/podoplanin. Involved in platelet adhesion being activated by ITGB3 engaged by fibrinogen
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
    Enzyme regulation: Autoinhibited. Intramolecular binding of the interdomains A and B (also called linker region)
    to parts of the catalytic domain keep the catalytic center in an inactive conformation. The phosphorylation of
    the interdomains or the binding of the SH2 domains with dually phosphorylated ITAM domains on transmembrane
    proteins disrupt those intramolecular interactions allowing the kinase domain to adopt an active conformation.
    The phosphorylation of SYK and of the ITAM domains which is responsible for SYK activation is essentially
    mediated by SRC subfamily kinases, like LYN, upon transmembrane receptors engagement. May also be negatively
    regulated by PTPN6 through dephosphorylation. Downstream signaling adapters and intermediates like BLNK or RHOH
    may mediate positive and/or negative feedback regulation. Negatively regulated by CBL and CBLB through
    ubiquitination and probable degradation. Phosphorylates SH3BP2 which in turn may regulate SYK through LYN (By
    similarity)

         Genatlas biochemistry entry for SYK:
    spleen tyrosine kinase,non SRC family,expressed in B,T and myeloid cells

         Enzyme Numbers (IUBMB): EC 2.7.10.21 2 EC 2.7.102

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity NAS12885943
    GO:0004713protein tyrosine kinase activity TAS--
    GO:0004715non-membrane spanning protein tyrosine kinase activity TAS--
    GO:0004716receptor signaling protein tyrosine kinase activity IEA--
    GO:0005178integrin binding IPI12885943
         
    SYK for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for SYK:
     Decreased substrate adherent c  Upregulation of Wnt/beta-caten 

         13 MGI mutant phenotypes (inferred from 10 alleles(MGI details for Syk):
     cardiovascular system  cellular  hematopoietic system  homeostasis/metabolism  immune system 
     limbs/digits/tail  liver/biliary system  mortality/aging  nervous system  no phenotypic analysis 
     renal/urinary system  respiratory system  skeleton 

    SYK for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for SYK: Syktm1.1Tara Syktm1Paw Syktm1Tyb

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SYK
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SYK

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SYK
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SYK

    miRNA
    Products:
        
    miRTarBase miRNAs that target SYK:
    hsa-mir-99b-3p (MIRT038521), hsa-mir-615-3p (MIRT040474), hsa-mir-331-3p (MIRT043443)

    Block miRNA regulation of human, mouse, rat SYK using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate SYK:
    hsa-miR-767-3p hsa-miR-2276 hsa-miR-4290 hsa-miR-497* hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmidSYK 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SYK
    Predesigned siRNA for gene silencing in human, mouse, rat SYK

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SYK

    Clone
    Products:
         
    OriGene clones in human, mouse for SYK (see all 22)
    OriGene ORF clones in mouse, rat for SYK
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): SYK (NM_003177)
    Sino Biological Human cDNA Clone for SYK
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SYK
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYK

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SYK
    Browse ESI BIO Cell Lines and PureStem Progenitors for SYK 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYK


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    KSYK_HUMAN, P43405: Cell membrane (Probable). Cytoplasm, cytosol (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol4
    cytoskeleton2
    extracellular2
    nucleus2
    endosome1
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--
    GO:0019815B cell receptor complex IEA--
    GO:0032009early phagosome ISS--

    SYK for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for SYK About   (see all 49)  
    See pathways by source

    SuperPathContained pathways About
    1Immune response Fc epsilon RI pathway
    Immune response Fc epsilon RI pathway0.43
    Fc epsilon RI signaling pathway0.41
    Immune response BCR pathway0.43
    Fc-epsilon receptor I signaling in mast cells0.34
    2Immune response Role of DAP12 receptors in NK cells
    Immune response Role of DAP12 receptors in NK cells0.33
    Natural killer cell mediated cytotoxicity0.31
    Immune response CD16 signaling in NK cells0.33
    3IL2-mediated signaling events
    IL-2 Signaling pathway0.49
    IL2-mediated signaling events0.49
    4B cell receptor signaling pathway (KEGG)
    B cell receptor signaling pathway0.42
    BCR signaling pathway0.42
    5CD28 co-stimulation
    GPVI-mediated activation cascade0.31
    CTLA4 Signaling0.30

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for SYK
        Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for SYK (see all 15)
        Fc-Gamma-RIIB Signaling in B-Cells
    Fc-GammaR Pathway
    TREM1 Pathway
    PI3K Signaling in B-Lymphocyte
    CD28 Signaling in T-Helper Cell

    2 Cell Signaling Technology (CST) Pathways for SYK
        Lymphocyte Signaling
    Tyrosine Kinases / Adaptors

    Selected GeneGo (Thomson Reuters) Pathways for SYK (see all 8)
        Development EPO-induced MAPK pathway
    Immune response CD16 signaling in NK cells
    Immune response BCR pathway
    Immune response IL-2 activation and signaling pathway
    Immune response NFAT in immune response

    Selected BioSystems Pathways for SYK (see all 13)
        IL-5 Signaling Pathway
    B Cell Receptor Signaling Pathway
    IL-3 Signaling Pathway
    IL-2 Signaling pathway
    RANKL/RANK Signaling Pathway


    Selected Reactome Pathways for SYK (see all 13)
        FCERI mediated MAPK activation
    FCGR activation
    Regulation of signaling by CBL
    Role of LAT2/NTAL/LAB on calcium mobilization
    GPVI-mediated activation cascade


    Selected Kegg Pathways  (Kegg details for SYK) (see all 10):
        NF-kappa B signaling pathway
    PI3K-Akt signaling pathway
    Osteoclast differentiation
    Natural killer cell mediated cytotoxicity
    B cell receptor signaling pathway


    SYK for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SYK: 
              Th17 Response in human mouse rat
              Lymphoma in human mouse rat
              Antifungal Response in human mouse rat
              Tumor Metastasis in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SYK

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SYK (P434051, 2, 3 ENSP000003648984) via UniProtKB, MINT, STRING, and/or I2D (see all 228)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ERBB2P046261, 2, 3, ENSP000002695714EBI-78302,EBI-641062 MINT-74765 MINT-74767 MINT-74769 MINT-74758 MINT-74768 MINT-74764 MINT-74766 I2D: score=2 STRING: ENSP00000269571
    CBLP226811, 2, 3, ENSP000002640334EBI-78302,EBI-518228 MINT-50721 MINT-50719 MINT-6538977 MINT-50720 MINT-6539663 MINT-50715 MINT-7301412 MINT-17273 I2D: score=6 STRING: ENSP00000264033
    LCKP062391, 2, 3, ENSP000003378254EBI-78302,EBI-1348 MINT-8036452 MINT-8036467 MINT-16945 MINT-8033612 MINT-56730 MINT-8036437 MINT-8033582 MINT-8033597 I2D: score=4 STRING: ENSP00000337825
    CD3EP077661, 2, 3, ENSP000003545664EBI-78302,EBI-1211297 MINT-8035866 MINT-8031546 MINT-8031561 MINT-8031530 MINT-8035897 MINT-8035882 I2D: score=4 STRING: ENSP00000354566
    EGFRP005331, 2, 3, ENSP000002754934EBI-78302,EBI-297353 MINT-74761 MINT-74757 MINT-74759 MINT-74760 MINT-74762 MINT-74763 I2D: score=2 STRING: ENSP00000275493
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 54):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000187activation of MAPK activity ----
    GO:0001525angiogenesis IEA--
    GO:0001820serotonin secretion ----
    GO:0001945lymph vessel development ISS--
    GO:0002250adaptive immune response ISS--

    SYK for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for SYK
    6 ApexBio Compounds for SYK     About this table
    CompoundAction CAS #
    BAY 61-3606potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity[732983-37-8]
    MNSSelective inhibitor of Src and Syk tyrosine kinases[1485-00-3]
    PiceatannolInhibits p56lck and syk protein tyrosine kinases[10083-24-6]
    PRT062607 HydrochloridePotent and selective Syk inhibitor[1370261-97-4]
    R406ATP-competitive Syk inhibitor[841290-81-1]
    R788ATP-competitive Syk inhibitor[1025687-58-4]

    Compounds for SYK available from Tocris Bioscience    About this table
    CompoundAction CAS #
    ER 27319 maleateSelective Syk kinase inhibitor[201010-95-9]
    PiceatannolInhibits TNF-induced NF-kappaB activation[10083-24-6]
    MNSSelective inhibitor of Src and Syk[1485-00-3]

    3 HMDB Compounds for SYK    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    CalciumCa (see all 2)7440-70-2--

    6 DrugBank Compounds for SYK    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Staurosporine-- 62996-74-1target--17139284 17016423
    2-{2-[(3,5-dimethylphenyl)amino]pyrimidin-4-yl}-N-[(1S)-2-hydroxy-1-methylethyl]-4-methyl-1,3-thiazole-5-carboxamide-- --target--10592235
    2-{[(1R,2S)-2-aminocyclohexyl]amino}-4-[(3-methylphenyl)amino]pyrimidine-5-carboxamide-- --target--10592235
    6-({5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]pyrimidin-4-yl}amino)-2,2-dimethyl-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one-- --target--10592235
    Ellagic Acid-- 476-66-4targetinhibitor16610779
    N-(2-hydroxy-1,1-dimethylethyl)-1-methyl-3-(1H-pyrrolo[2,3-b]pyridin-2-yl)-1H-indole-5-carboxamide-- --target--10592235

    Selected Novoseek inferred chemical compound relationships for SYK gene (see all 74)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    piceatannol 93.2 94 10194444 (4), 10586078 (4), 15123770 (2), 12393431 (2) (see all 50)
    tyrosine 90.8 1368 9186005 (6), 10931839 (6), 7538118 (6), 9208937 (5) (see all 99)
    convulxin 76.2 8 9670039 (2), 10217417 (1), 10942756 (1), 11278467 (1) (see all 6)
    phosphotyrosine 69.1 11 8590001 (1), 10075687 (1), 18689684 (1), 19421152 (1) (see all 11)
    pp55 67.3 1 9195899 (1)
    4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine 64.7 4 14978183 (1), 15107458 (1), 19797620 (1)
    phosphatidylinositol 62.2 25 12477728 (5), 11698498 (3), 9183664 (1), 7831290 (1) (see all 18)
    wortmannin 53.2 7 10586078 (2), 11698498 (1), 16918505 (1), 14699155 (1) (see all 5)
    bis(maltolato)oxovanadium(iv) 52.2 1 7657667 (1)
    phosphoinositide 51.3 14 11331248 (1), 20367574 (1), 12077122 (1), 11907067 (1) (see all 13)



    SYK for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for SYK gene (4 alternative transcripts): 
    NM_001135052.2  NM_001174167.1  NM_001174168.1  NM_003177.5  

    Unigene Cluster for SYK:

    Spleen tyrosine kinase
    Hs.371720  [show with all ESTs]
    Unigene Representative Sequence: NM_003177
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000375754(uc004aqz.3) ENST00000375751(uc004ara.3) ENST00000375747(uc004arb.3)
    ENST00000476708 ENST00000375746(uc004arc.3 uc011ltt.2 uc011ltr.2 uc011lts.2)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SYK using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate SYK:
    hsa-miR-767-3p hsa-miR-2276 hsa-miR-4290 hsa-miR-497* hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmidSYK 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SYK
    Predesigned siRNA for gene silencing in human, mouse, rat SYK
    Clone
    Products:
         
    OriGene clones in human, mouse for SYK (see all 22)
    OriGene ORF clones in mouse, rat for SYK
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): SYK (NM_003177)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SYK
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYK
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SYK
    OriGene qSTAR qPCR primer pairs in human, mouse for SYK
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SYK
      QuantiTect SYBR Green Assays in human, mouse, rat SYK
      QuantiFast Probe-based Assays in human, mouse, rat SYK

    Additional mRNA sequence: 

    AJ420449.1 AK057772.1 AK075020.1 AK290927.1 BC001645.2 BC002962.1 BC011399.1 FN391891.1 
    FN391892.1 FN391893.1 L28824.1 S80267.1 X73568.1 Z29630.1 

    19 DOTS entries:

    DT.113736  DT.100775429  DT.100775428  DT.100736526  DT.86850732  DT.100775425  DT.95161192  DT.87016326 
    DT.95212498  DT.100743088  DT.100651169  DT.100739866  DT.121160422  DT.91994386  DT.95161189  DT.95161195 
    DT.100026638  DT.97815100  DT.91768282 

    Selected AceView cDNA sequences (see all 315):

    T92606 BM542999 AA804654 AV651074 AI014662 AI871668 BQ011658 AK057772 
    AA486583 BM542806 AW575750 AA878639 AK075020 AW170502 AW575809 BQ064905 
    BG315206 W33093 AW575810 AA907259 BC011399 BQ223631 CA394477 AL832053 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SYK (see all 10)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a ·
    SP1:                                                        -                                         -                                                         
    SP2:        -     -     -     -     -                       -                                         -                                                         
    SP3:        -     -     -     -     -                       -                                   -     -                                                         
    SP4:                    -     -     -                       -                                   -     -                                                         
    SP5:                                                        -           -     -     -     -     -     -     -     -                                             

    ExUns: 17b · 17c ^ 18
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for SYK

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    SYK expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGACTGATCC
    SYK Expression
    About this image


    SYK expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Myoblasts Mandibular Arch Muscles
     
     Ovary (Reproductive System)
             Oviduct
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Blood (Hematopoietic System)
             Plasmacytoid Dendritic cells Peripheral Blood
    SYK Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SYK Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.371720

    UniProtKB/Swiss-Prot: KSYK_HUMAN, P43405
    Tissue specificity: Widely expressed in hematopoietic cells (at protein level). Within the B-cells compartment it
    is for instance expressed for pro-B-cells to plasma cells

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SYK: 
              Th17 Response in human mouse rat
              Lymphoma in human mouse rat
              Antifungal Response in human mouse rat
              Tumor Metastasis in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SYK
    OriGene qSTAR qPCR primer pairs in human, mouse for SYK
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SYK
    QuantiTect SYBR Green Assays in human, mouse, rat SYK
    QuantiFast Probe-based Assays in human, mouse, rat SYK
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYK

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for SYK gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Syk1 , 5 spleen tyrosine kinase1, 5 85.43(n)1
    93(a)1
      13 (27.41 cM)5
    209631  NM_001198977.11  NP_001185906.11 
     525831735 
    chicken
    (Gallus gallus)
    Aves SYK1 spleen tyrosine kinase 72.71(n)
    80.56(a)
      427272  NM_001031430.1  NP_001026601.1 
    lizard
    (Anolis carolinensis)
    Reptilia SYK6
    spleen tyrosine kinase
    75(a)
    1 ↔ 1
    2(32078575-32126403)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC687542 hypothetical protein MGC68754 72.87(n)    BC061936.1 
    zebrafish
    (Danio rerio)
    Actinopterygii syk1 spleen tyrosine kinase 67.3(n)
    71.55(a)
      405769  NM_212843.1  NP_998008.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta shark6
    SH2 ankyrin repeat kinase
    21(a)
    1 → many
    2R(12086931-12090388)
    worm
    (Caenorhabditis elegans)
    Secernentea ark-16
    Protein ARK-1, isoform a (ark-1) mRNA, complete cd...
    11(a)
    many ↔ many
    IV(12622084-12631022) WBGene00000186


    ENSEMBL Gene Tree for SYK (if available)
    TreeFam Gene Tree for SYK (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for SYK gene
    TNK12  JAK32  JAK22  TNK22  TYK22  ERBB42  JAK12  ERBB32  
    PTK22  ERBB22  ZAP702  EGFR2  PTK2B2  
    4 SIMAP similar genes for SYK using alignment to 3 protein entries:     KSYK_HUMAN (see all proteins):
    p72syk    ZAP70    EPHA2    PTPN11

    SYK for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for SYK (see all 2742)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs58991041,2
    C--93566299(+) TTACC-/AAAAAA 3 -- int1 trp30--------
    rs715096641,2
    C--93567237(+) TGAGG-/T/TT  
            
    TTTTT
    3 -- int11NA 2
    rs58991051,2
    C--93567246(+) TTTTT-/T/TT  
            
    CCTTT
    3 -- int1 trp31NA 2
    rs38383361,2
    C--93569179(+) NNNNN-/ATTTTTG
    /ATTTTTGT
    ATTTT
    3 -- int10--------
    rs58991061,2
    C--93569814(+) GGTAC-/CTGGTA 3 -- int11Minor allele frequency- C:0.00CSA 2
    rs105732131,2
    C--93570744(+) GTTGG-/T/TT  
            
    TTTTT
    3 -- int10--------
    rs790952911,2
    C--93572779(+) AACTTG/TGGGGG 3 -- int10--------
    rs1460636361,2
    C--93572885(+) GATAT-/AGGAGA 3 -- int10--------
    rs58991071,2
    C,F--93573351(+) AACTTA/-GGTGA 3 -- int12Minor allele frequency- -:0.50NA 4
    rs759231601,2
    C--93573351(+) AACTTA/G/TGGTGA 3 -- int10--------

    HapMap Linkage Disequilibrium report for SYK (93564012 - 93660842 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SYK (see all 17):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2738748CNV Deletion23290073
    esv2738752CNV Deletion23290073
    esv2738753CNV Deletion23290073
    esv2738750CNV Deletion23290073
    esv2738754CNV Deletion23290073
    esv2664340CNV Deletion23128226
    esv2738749CNV Deletion23290073
    esv2669899CNV Deletion23128226
    esv1404670CNV Insertion17803354
    esv24177CNV Loss19812545

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SYK
    DNA2.0 Custom Variant and Variant Library Synthesis for SYK

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 600085    OMIM disorders: --

    Selected diseases for SYK (see all 78):    
    About MalaCards
    zap-70 deficiency    mycobacterium abscessus    cherubism    splenic marginal zone lymphoma
    peripheral t-cell lymphoma    wiskott-aldrich syndrome    lymphedema    leukemia/lymphoma, t-cell
    allergic rhinitis    rhinitis    mediastinitis    follicular lymphoma
    vascular dementia    urticaria    allergic asthma    burkitt's lymphoma
    chronic lymphocytic leukemia    mantle cell lymphoma    diffuse large b-cell lymphoma    cutaneous t cell lymphoma

    5 diseases from the University of Copenhagen DISEASES database for SYK:
    Leukemia     Lymphoma     Arthritis     Asthma
    Cherubism

    SYK for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for SYK gene (see all 50)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia lymphocytic chronic 49.7 5 19549911 (1), 19092849 (1), 19965662 (1), 20335218 (1) (see all 5)
    lymphoma b-cell 42.2 9 16912221 (1), 19092849 (1), 19296913 (1), 19965662 (1) (see all 7)
    lymphocytic leukemia chronic b-cell 41.1 6 16912221 (1), 19092849 (1), 19296913 (1), 19144411 (1)
    leukemia b-cell 37.4 2 16912221 (1), 19092849 (1)
    wiskott-aldrich syndrome 34.5 2 16460447 (1), 11313252 (1)
    leukemia basophilic 32.9 3 7513161 (1), 12193692 (1), 14996825 (1)
    lymphoma t-cell peripheral 32.4 1 16341044 (1)
    autoimmune diseases 31.2 13 15212616 (2), 19220318 (1), 17662659 (1), 20013945 (1) (see all 8)
    rheumatoid arthritis 29.9 8 17537677 (2), 18447591 (1), 19530990 (1), 20001666 (1) (see all 6)
    lymphoma 29.8 21 17182546 (5), 20133729 (3), 16670274 (2), 9565626 (1) (see all 10)

    Genetic Association Database (GAD): SYK
    Human Genome Epidemiology (HuGE) Navigator: SYK (3 documents)

    Export disorders for SYK gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for SYK gene, integrated from 10 sources (see all 921):
    (articles sorted by number of sources associating them with SYK)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular mechanism of the Syk activation switch. (PubMed id 18818202)1, 2, 9 Tsang E.... Bradshaw J.M. (J. Biol. Chem. 2008)
    2. Phospholipase C-gamma1 interacts with conserved phosphotyrosyl residues in the linker region of Syk and is a substrate for Syk. (PubMed id 8657103)1, 2, 9 Law C.L.... Clark E.A. (Mol. Cell. Biol. 1996)
    3. Coordinated regulation of the tyrosine phosphorylation of Cbl by Fyn and Syk tyrosine kinases. (PubMed id 9535867)1, 2, 9 Deckert M.... Liu Y.C. (J. Biol. Chem. 1998)
    4. Molecular cloning of human Syk. A B cell protein-tyrosine kinase associated with the surface immunoglobulin M-B cell receptor complex. (PubMed id 8163536)1, 2, 9 Law C.-L.... Clark E.A. (J. Biol. Chem. 1994)
    5. Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton. (PubMed id 11940607)1, 2, 9 Obergfell A.... Shattil S.J. (J. Cell Biol. 2002)
    6. Structural basis for Syk tyrosine kinase ubiquity in signal transduction pathways revealed by the crystal structure of its regulatory SH2 domains bound to a dually phosphorylated ITAM peptide. (PubMed id 9698567)1, 2, 9 Fuetterer K.... Waksman G. (J. Mol. Biol. 1998)
    7. Integral membrane protein 2 of Epstein-Barr virus regulates reactivation from latency through dominant negative effects on protein-tyrosine kinases. (PubMed id 7895172)1, 2, 9 Miller C.L.... Kieff E. (Immunity 1995)
    8. Cloning of the cDNA for the deleted syk kinase homologous to ZAP-70 from human basophilic leukemia cell line (KU812). (PubMed id 7513161)1, 2, 9 Yagi S.... Ra C. (Biochem. Biophys. Res. Commun. 1994)
    9. Association of the Src homology 2 domain-containing leukocyte phosphoprotein of 76 kD (SLP-76) with the p85 subunit of phosphoinositide 3-kinase. (PubMed id 15388330)1, 2, 9 Shim E.K.... Lee J.R. (FEBS Lett. 2004)
    10. ITAM-based interaction of ERM proteins with Syk mediates signaling by the leukocyte adhesion receptor PSGL-1. (PubMed id 12387735)1, 2, 9 Urzainqui A....Sanchez-Madrid F. (Immunity 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 6850 HGNC: 11491 AceView: SYK Ensembl:ENSG00000165025 euGenes: HUgn6850
    ECgene: SYK Kegg: 6850 H-InvDB: SYK

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SYK Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SYK Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SYK gene:
    Search GeneIP for patents involving SYK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Small Molecules at EMD Millipore
     EMD Millipore Purified and/or Recombinant SYK Protein
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of SYK
     
     EMD Millipore genomic analysis products

      
     Antibodies for SYK (SYK)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for SYK (SYK)   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for SYK   OriGene RNAi products in human, mouse, rat for SYK  
     OriGene qPCR primer pairs and template standards for SYK   OriGene Protein Over-expression Lysate for SYK  
     OriGene MassSpec something-or-other for SYK   OriGene clones in human, mouse for SYK  
     OriGene qSTAR qPCR primer pairs in human, mouse for SYK   OriGene Purified Protein for SYK  
     OriGene ORF clones in mouse, rat for SYK   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SYK   OriGene Custom Protein Services for SYK  

     
     
     Block miRNA regulation of human, mouse, rat SYK using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SYK
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SYK Predesigned siRNA for gene silencing in human, mouse, rat SYK
     QuantiFast Probe-based Assays in human, mouse, rat SYK QuantiTect SYBR Green Assays in human, mouse, rat SYK
     PCR Arrays including human, mouse, rat SYK Search Chromatin IP Primers for SYK
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SYK  GeneGlobe Interaction Network for SYK
     Regulatory tfbs in SYK promoter
     GenScript Custom Purified and Recombinant Proteins Services for SYK GenScript cDNA clones with any tag delivered in your preferred vector for SYK
     GenScript Custom Assay Services for SYK GenScript Custom overexpressing Cell Line Services for SYK
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for SYK 

     Tocris compounds for SYK
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for SYK
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Drugs for SYK
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SYK antibodies
     SYK proteins
     SYK lysates
     Antibodies for SYK
     See all of Abcam's Antibodies, Kits and Proteins for SYK
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for SYK
     Proteins for SYK
     Antibodies for SYK
     ELISAs for SYK
     CLIAs for SYK



     Browse ESI BIO Cell Lines and PureStem Progenitors for SYK
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYK
     SwitchGear 3'UTR luciferase reporter plasmids for SYK
     SwitchGear Promoter luciferase reporter plasmids for SYK
     ThermoFisher Antibody for SYK
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYK
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SYK
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SYK
     LSBio Antibodies in human, mouse, rat for SYK
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     ApexBio compounds for SYK
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SYK gene at Home site.
    Version: 3.12.162 20 Aug 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4