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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SYK Gene

protein-coding   GIFtS: 75
GCID: GC09P093564

Spleen Tyrosine Kinase

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Spleen Tyrosine Kinase1 2 3
p72-Syk2 3
EC 2.7.10.23 8
Tyrosine-Protein Kinase SYK2
EC 2.7.108

External Ids:    HGNC: 114911   Entrez Gene: 68502   Ensembl: ENSG000001650257   OMIM: 6000855   UniProtKB: P434053   

Export aliases for SYK gene to outside databases

Previous GC identifers: GC09P084403 GC09P085292 GC09P086863 GC09P088905 GC09P090643 GC09P092603 GC09P063244


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SYK Gene:
This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely
expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling
events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is
thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas.
Alternatively spliced transcript variants encoding different isoforms have been found for this gene. (provided by
RefSeq, Mar 2010)

GeneCards Summary for SYK Gene: 
SYK (spleen tyrosine kinase) is a protein-coding gene. Diseases associated with SYK include zap-70 deficiency, and mycobacterium abscessus, and among its related super-pathways are Immune response Role of DAP12 receptors in NK cells and IL2-mediated signaling events. GO annotations related to this gene include integrin binding and protein kinase binding. An important paralog of this gene is TNK1.

UniProtKB/Swiss-Prot: KSYK_HUMAN, P43405
Function: Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane
receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological
processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and
vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via
interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with
the receptor can also be indirect and mediated by adapter proteins containing ITAM or partial hemITAM domains.
The phosphorylation of the ITAM domains is generally mediated by SRC subfamily kinases upon engagement of the
receptor. More rarely signal transduction via SYK could be ITAM-independent. Direct downstream effectors
phosphorylated by SYK include VAV1, PLCG1, PI-3-kinase, LCP2 and BLNK. Initially identified as essential in
B-cell receptor (BCR) signaling, it is necessary for the maturation of B-cells most probably at the pro-B to
pre-B transition. Activated upon BCR engagement, it phosphorylates and activates BLNK an adapter linking the
activated BCR to downstream signaling adapters and effectors. It also phosphorylates and activates PLCG1 and the
PKC signaling pathway. It also phosphorylates BTK and regulates its activity in B-cell antigen receptor
(BCR)-coupled signaling. Beside its function downstream of BCR plays also a role in T-cell receptor signaling.
Plays also a crucial role in the innate immune response to fungal, bacterial and viral pathogens. It is for
instance activated by the membrane lectin CLEC7A. Upon stimulation by fungal proteins, CLEC7A together with SYK
activates immune cells inducing the production of ROS. Also activates the inflammasome and NF-kappa-B-mediated
transcription of chemokines and cytokines in presence of pathogens. Regulates neutrophil degranulation and
phagocytosis through activation of the MAPK signaling cascade. Also mediates the activation of dendritic cells by
cell necrosis stimuli. Also involved in mast cells activation. Also functions downstream of receptors mediating
cell adhesion. Relays for instance, integrin-mediated neutrophils and macrophages activation and P-selectin
receptor/SELPG-mediated recruitment of leukocytes to inflammatory loci. Plays also a role in non-immune
processes. It is for instance involved in vascular development where it may regulate blood and lymphatic vascular
separation. It is also required for osteoclast development and function. Functions in the activation of platelets
by collagen, mediating PLCG2 phosphorylation and activation. May be coupled to the collagen receptor by the ITAM
domain-containing FCER1G. Also activated by the membrane lectin CLEC1B that is required for activation of
platelets by PDPN/podoplanin. Involved in platelet adhesion being activated by ITGB3 engaged by fibrinogen

summary for SYK Gene:
Spleen tyrosine kinase (Syk) is a non-receptor cytoplasmic enzyme that is primarily expressed in cells of
hematopoietic lineage. Syk contains two adjacent SH2 domains that bind to immunoreceptor tyrosine-based
activation motifs (ITAMs) to activate and autophosphorylate the enzyme. This allows Syk to phosphorylate its
specific substrates including other enzymes and adaptor proteins, orchestrating a complex series of cellular
responses such as cell proliferation, differentiation, survival and phagocytosis. Recently, Syk has been
found to be expressed in a variety of other cells including fibroblasts (where it mediates adipogenesis),
epithelial cells (where it controls cell division and acts as a tumor suppressor), hepatocytes (where it is
involved in ERK activation) and neuronal cells (where it is involved in neuronal differentiation).

Gene Wiki entry for SYK (Syk) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NT_008470.19  NC_018920.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SYK gene promoter:
         AhR   STAT1   p53   AP-1   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSYK promoter sequence
   Search SABiosciences Chromatin IP Primers for SYK

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SYK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q22   Ensembl cytogenetic band:  9q22.2   HGNC cytogenetic band: 9q22

SYK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SYK gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P093564:  view genomic region     (about GC identifiers)

Start:
93,564,012 bp from pter      End:
93,660,842 bp from pter
Size:
96,831 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KSYK_HUMAN, P43405 (See protein sequence)
Recommended Name: Tyrosine-protein kinase SYK  
Size: 635 amino acids; 72066 Da
Subunit: Interacts with LYN; phosphorylates SYK (By similarity). Interacts with RHOH (phosphorylated); regulates
mast cells activation (By similarity). Interacts with NFAM1 (phosphorylated); probably involved in BCR signaling
(By similarity). Interacts with VAV1 (via SH2 domain); phosphorylates VAV1 upon BCR activation. Interacts with
GAB2 (phosphorylated); probably involved in IgE Fc receptor signaling (By similarity). Interacts (via its SH2
domains) with CD79A (via its phosphorylated ITAM domain); the interaction stimulates SYK autophosphorylation and
activation (By similarity). Interacts with FCRL3. Interacts (via SH2 domains) with FCER1G (via ITAM domain);
activates SYK and mediates neutrophils and macrophages integrin-mediated activation (By similarity). Interacts
with ITGB2 and FGR; involved in ITGB2 downstream signaling (By similarity). Interacts with ITGB3; upon activation
by ITGB3 promotes platelet adhesion. Interacts (via SH2 domains) with TYROBP (via ITAM domain); involved in
neutrophils and macrophages integrin-mediated activation (By similarity). Interacts with MSN and SELPLG; mediates
the selectin-dependent activation of SYK by SELPLG. Interacts with BLNK (via SH2 domain). Interacts (via the
second SH2 domain) with USP25 (via C-terminus); phosphorylates USP25 and regulates USP25 intracellular levels.
Interacts (via SH2 domains) with CLEC1B (dimer). Interacts with CLEC7A; participates in leukocyte activation in
presence of fungal pathogens. Interacts (phosphorylated) with SLA; may regulate SYK through CBL recruitment.
Interacts with YWHAG; attenuates BCR-induced membrane translocation and activation of SYK. Interacts with
Epstein-Barr virus LMP2A
Subcellular location: Cell membrane (Probable). Cytoplasm, cytosol (Probable)
6/26 PDB 3D structures from and Proteopedia for SYK (see all 26):
1A81 (3D)        1CSY (3D)        1CSZ (3D)        1XBA (3D)        1XBB (3D)        1XBC (3D)    
Alternative splicing: 2 isoforms:  P43405-1   P43405-2   

Explore the universe of human proteins at neXtProt for SYK: NX_P43405

Explore proteomics data for SYK at MOPED 

Post-translational modifications:

  • UniProtKB: Ubiquitinated by CBLB after BCR activation; which promotes proteasomal degradation (By similarity)
  • UniProtKB: Autophosphorylated. Phosphorylated on tyrosine residues by LYN following receptors engagement. Phosphorylation on
    Tyr-323 creates a binding site for CBL, an adapter protein that serves as a negative regulator of BCR-stimulated
    calcium ion signaling. Phosphorylation at Tyr-348 creates a binding site for VAV1. Phosphorylation on Tyr-348 and
    Tyr-352 enhances the phosphorylation and activation of phospholipase C-gamma and the early phase of calcium ion
    mobilization via a phosphoinositide 3-kinase-independent pathway (By similarity). Phosphorylation on Ser-297 is
    very common, it peaks 5 minutes after BCR stimulation, and creates a binding site for YWHAG. Phosphorylation at
    Tyr-630 creates a binding site for BLNK. Dephosphorylated by PTPN6
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P43405

  • 4/19 DME Specific Peptides for SYK (P43405) (see all 19)
     RDLAARN  FVHRDLA  AARNVLL  SYGQKPY 

    SYK Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SYK Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001128524.1  NP_001167638.1  NP_001167639.1  NP_003168.2  

    ENSEMBL proteins: 
     ENSP00000364907   ENSP00000364904   ENSP00000364899   ENSP00000364898  
    Reactome Protein details: P43405
    Human Recombinant Protein Products for SYK: 
    EMD Millipore Purified and/or Recombinant SYK Protein
    R&D Systems Recombinant & Natural Proteins for SYK
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for SYK
    OriGene Protein Over-expression Lysate for SYK
    OriGene MassSpec for SYK 
    OriGene Custom Protein Services for SYK
    GenScript Custom Purified and Recombinant Proteins Services for SYK
    Novus Biologicals SYK Proteins
    Novus Biologicals SYK Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for SYK
    Cloud-Clone Corp. Proteins for SYK 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--
    GO:0019815B cell receptor complex IEA--
    GO:0032009early phagosome ISS--

    SYK for ontologies           About GeneDecksing



    SYK Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of SYK
    R&D Systems Antibodies for SYK
    Cell Signaling Technology (CST) Antibodies for SYK 
    OriGene Antibodies for SYK
    OriGene Custom Antibody Services for SYK
    GenScript Superior Antibodies for SYK
    Novus Biologicals SYK Antibodies
    Abcam antibodies for SYK
    Cloud-Clone Corp. Antibodies for SYK 
    ThermoFisher Antibody for SYK
    LSBio Antibodies in human, mouse, rat for SYK 

    Assay Products for SYK: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SYK
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SYK
    Cell Signaling Technology (CST) Sandwich ELISA Kits for SYK
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SYK 
    Cloud-Clone Corp. CLIAs for SYK


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SH2D: SH2 domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: spleen tyrosine kinase 
    Syk family

    5/9 InterPro protein domains (see all 9):
     IPR012234 Tyr_kinase_non-rcpt_SYK/ZAP70
     IPR017441 Protein_kinase_ATP_BS
     IPR001245 Ser-Thr/Tyr_kinase_cat_dom
     IPR011009 Kinase-like_dom
     IPR000980 SH2

    Graphical View of Domain Structure for InterPro Entry P43405

    ProtoNet protein and cluster: P43405

    2 Blocks protein domains:
    IPB000980 SH2 domain signature
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: KSYK_HUMAN, P43405
    Domain: The SH2 domains mediate the interaction of SYK with the phosphorylated ITAM domains of transmembrane
    proteins. Some proteins like CLEC1B have a partial ITAM domain (also called hemITAM) containing a single YxxL
    motif. The interaction with SYK requires CLEC1B homodimerization
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. SYK/ZAP-70 subfamily
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 2 SH2 domains


    SYK for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KSYK_HUMAN, P43405
    Function: Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane
    receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological
    processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and
    vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via
    interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with
    the receptor can also be indirect and mediated by adapter proteins containing ITAM or partial hemITAM domains.
    The phosphorylation of the ITAM domains is generally mediated by SRC subfamily kinases upon engagement of the
    receptor. More rarely signal transduction via SYK could be ITAM-independent. Direct downstream effectors
    phosphorylated by SYK include VAV1, PLCG1, PI-3-kinase, LCP2 and BLNK. Initially identified as essential in
    B-cell receptor (BCR) signaling, it is necessary for the maturation of B-cells most probably at the pro-B to
    pre-B transition. Activated upon BCR engagement, it phosphorylates and activates BLNK an adapter linking the
    activated BCR to downstream signaling adapters and effectors. It also phosphorylates and activates PLCG1 and the
    PKC signaling pathway. It also phosphorylates BTK and regulates its activity in B-cell antigen receptor
    (BCR)-coupled signaling. Beside its function downstream of BCR plays also a role in T-cell receptor signaling.
    Plays also a crucial role in the innate immune response to fungal, bacterial and viral pathogens. It is for
    instance activated by the membrane lectin CLEC7A. Upon stimulation by fungal proteins, CLEC7A together with SYK
    activates immune cells inducing the production of ROS. Also activates the inflammasome and NF-kappa-B-mediated
    transcription of chemokines and cytokines in presence of pathogens. Regulates neutrophil degranulation and
    phagocytosis through activation of the MAPK signaling cascade. Also mediates the activation of dendritic cells by
    cell necrosis stimuli. Also involved in mast cells activation. Also functions downstream of receptors mediating
    cell adhesion. Relays for instance, integrin-mediated neutrophils and macrophages activation and P-selectin
    receptor/SELPG-mediated recruitment of leukocytes to inflammatory loci. Plays also a role in non-immune
    processes. It is for instance involved in vascular development where it may regulate blood and lymphatic vascular
    separation. It is also required for osteoclast development and function. Functions in the activation of platelets
    by collagen, mediating PLCG2 phosphorylation and activation. May be coupled to the collagen receptor by the ITAM
    domain-containing FCER1G. Also activated by the membrane lectin CLEC1B that is required for activation of
    platelets by PDPN/podoplanin. Involved in platelet adhesion being activated by ITGB3 engaged by fibrinogen
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
    Enzyme regulation: Autoinhibited. Intramolecular binding of the interdomains A and B (also called linker region)
    to parts of the catalytic domain keep the catalytic center in an inactive conformation. The phosphorylation of
    the interdomains or the binding of the SH2 domains with dually phosphorylated ITAM domains on transmembrane
    proteins disrupt those intramolecular interactions allowing the kinase domain to adopt an active conformation.
    The phosphorylation of SYK and of the ITAM domains which is responsible for SYK activation is essentially
    mediated by SRC subfamily kinases, like LYN, upon transmembrane receptors engagement. May also be negatively
    regulated by PTPN6 through dephosphorylation. Downstream signaling adapters and intermediates like BLNK or RHOH
    may mediate positive and/or negative feedback regulation. Negatively regulated by CBL and CBLB through
    ubiquitination and probable degradation. Phosphorylates SH3BP2 which in turn may regulate SYK through LYN (By
    similarity)

         Genatlas biochemistry entry for SYK:
    spleen tyrosine kinase,non SRC family,expressed in B,T and myeloid cells

         Enzyme Numbers (IUBMB): EC 2.7.10.21 2 EC 2.7.102

         Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity NAS12885943
    GO:0004713protein tyrosine kinase activity TAS--
    GO:0004715non-membrane spanning protein tyrosine kinase activity TAS--
    GO:0004716receptor signaling protein tyrosine kinase activity IEA--
    GO:0005178integrin binding IPI12885943
         
    SYK for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for SYK:
     Decreased substrate adherent c  Upregulation of Wnt/beta-caten 

         13 MGI mutant phenotypes (inferred from 10 alleles(MGI details for Syk):
     cardiovascular system  cellular  hematopoietic system  homeostasis/metabolism  immune system 
     limbs/digits/tail  liver/biliary system  mortality/aging  nervous system  no phenotypic analysis 
     renal/urinary system  respiratory system  skeleton 

    SYK for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for SYK: Syktm1.1Tara Syktm1Paw Syktm1Tyb

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SYK 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SYK

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SYK 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SYK 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SYK
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate SYK:
    hsa-miR-767-3p hsa-miR-2276 hsa-miR-4290 hsa-miR-497* hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmidSYK 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SYK
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SYK

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SYK
    Sirion Biotech Customized adenovirus for overexpression of SYK

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for SYK (see all 18)
    OriGene ORF clones in mouse, rat for SYK
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): SYK (NM_003177)
    Sino Biological Human cDNA Clone for SYK
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SYK
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYK
    Sirion Biotech Customized lentivirus for stable overexpression of SYK 
                         Customized lentivirus expression plasmids for stable overexpression of SYK 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SYK
    Search LifeMap BioReagents cell lines for SYK
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYK


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SYK About   (see all 51)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Immune response Fc epsilon RI pathway
    Immune response Fc epsilon RI pathway0.45
    Immune response CD16 signaling in NK cells0.32
    Immune response BCR pathway0.45
    Immune response Role of DAP12 receptors in NK cells0.32
    Fc epsilon RI signaling pathway0.40
    Natural killer cell mediated cytotoxicity0.31
    Fc-epsilon receptor I signaling in mast cells0.33
    2IL-2 Signaling pathway
    IL2-mediated signaling events0.49
    IL-2 Signaling pathway0.49
    3B cell receptor signaling pathway
    B cell receptor signaling pathway0.42
    BCR signaling pathway0.42
    4Interleukin-3, 5 and GM-CSF signaling
    Interleukin-2 signaling0.67
    Regulation of signaling by CBL0.45
    Interleukin-3, 5 and GM-CSF signaling0.57
    Signaling by Interleukins0.45
    5FCERI mediated Ca+2 mobilization
    FCERI mediated Ca+2 mobilization0.60
    Antigen Activates B Cell Receptor Leading to Generation of Second Messengers0.31
    FCERI mediated MAPK activation0.60

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/8 EMD Millipore Pathways for SYK (see all 8)
        Immune response BCR pathway
    Immune response CD16 signaling in NK cells
    Immune response Role of DAP12 receptors in NK cells
    Signal transduction IP3 signaling
    Development EPO-induced MAPK pathway

    1 R&D Systems Pathway for SYK
        Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways

    5/15 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for SYK (see all 15)
        Fc-Gamma-RIIB Signaling in B-Cells
    Fc-GammaR Pathway
    TREM1 Pathway
    PI3K Signaling in B-Lymphocyte
    CD28 Signaling in T-Helper Cell

    2 Cell Signaling Technology (CST) Pathways for SYK
        Lymphocyte Signaling
    Tyrosine Kinases / Adaptors

    5/8 GeneGo (Thomson Reuters) Pathways for SYK (see all 8)
        Development EPO-induced MAPK pathway
    Immune response CD16 signaling in NK cells
    Immune response BCR pathway
    Immune response IL-2 activation and signaling pathway
    Immune response NFAT in immune response

    5/13 BioSystems Pathways for SYK (see all 13)
        IL-5 Signaling Pathway
    IL-3 Signaling Pathway
    IL-2 Signaling pathway
    B Cell Receptor Signaling Pathway
    RANKL/RANK Signaling Pathway


    5/27        Reactome Pathways for SYK (see all 27)
        FCERI mediated MAPK activation
    FCGR activation
    Regulation of signaling by CBL
    DAP12 interactions
    DAP12 signaling


    5/10         Kegg Pathways  (Kegg details for SYK) (see all 10):
        NF-kappa B signaling pathway
    PI3K-Akt signaling pathway
    Osteoclast differentiation
    Natural killer cell mediated cytotoxicity
    B cell receptor signaling pathway


    SYK for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SYK

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/223 Interacting proteins for SYK (P434051, 2, 3 ENSP000003648984) via UniProtKB, MINT, STRING, and/or I2D (see all 223)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CBLP226812, 3, ENSP000002640334MINT-50721 MINT-50719 MINT-6538977 MINT-50720 MINT-50715 MINT-6539663 MINT-7301412 MINT-17273 I2D: score=6 STRING: ENSP00000264033
    LCKP062392, 3, ENSP000003378254MINT-8036452 MINT-8036467 MINT-16945 MINT-8033612 MINT-56730 MINT-8036437 MINT-8033582 MINT-8033597 I2D: score=4 STRING: ENSP00000337825
    ERBB2P046262, 3, ENSP000002695714MINT-74765 MINT-74767 MINT-74769 MINT-74758 MINT-74768 MINT-74764 MINT-74766 I2D: score=2 STRING: ENSP00000269571
    CD3EP077662, 3, ENSP000003545664MINT-8035866 MINT-8031546 MINT-8031561 MINT-8031530 MINT-8035897 MINT-8035882 I2D: score=4 STRING: ENSP00000354566
    EGFRP005332, 3, ENSP000002754934MINT-74761 MINT-74757 MINT-74759 MINT-74760 MINT-74762 MINT-74763 I2D: score=2 STRING: ENSP00000275493
    About this table

    Gene Ontology (GO): 5/53 biological process terms (GO ID links to tree view) (see all 53):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000187activation of MAPK activity ----
    GO:0001525angiogenesis IEA--
    GO:0001820serotonin secretion ----
    GO:0001945lymph vessel development ISS--
    GO:0002250adaptive immune response ISS--

    SYK for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SYK for compounds           About GeneDecksing

    EMD Millipore small molecules for SYK:
    Small Molecule - inhibitor
    Enzo Life Sciences drugs & compounds for SYK

    Compounds for SYK available from Tocris Bioscience    About this table
    CompoundAction CAS #
    ER 27319 maleateSelective Syk kinase inhibitor[201010-95-9]
    PiceatannolInhibits TNF-induced NF-kappaB activation[10083-24-6]
    MNSSelective inhibitor of Src and Syk[1485-00-3]

    3 HMDB Compounds for SYK    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    CalciumCa (see all 2)7440-70-2--

    6 DrugBank Compounds for SYK    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Staurosporine-- 62996-74-1target--17139284 17016423
    2-{2-[(3,5-dimethylphenyl)amino]pyrimidin-4-yl}-N-[(1S)-2-hydroxy-1-methylethyl]-4-methyl-1,3-thiazole-5-carboxamide-- --target--10592235
    2-{[(1R,2S)-2-aminocyclohexyl]amino}-4-[(3-methylphenyl)amino]pyrimidine-5-carboxamide-- --target--10592235
    6-({5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]pyrimidin-4-yl}amino)-2,2-dimethyl-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one-- --target--10592235
    Ellagic Acid-- 476-66-4targetinhibitor16610779
    N-(2-hydroxy-1,1-dimethylethyl)-1-methyl-3-(1H-pyrrolo[2,3-b]pyridin-2-yl)-1H-indole-5-carboxamide-- --target--10592235

    10/74 Novoseek inferred chemical compound relationships for SYK gene (see all 74)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    piceatannol 93.2 94 10194444 (4), 10586078 (4), 15123770 (2), 12393431 (2) (see all 50)
    tyrosine 90.8 1368 9186005 (6), 10931839 (6), 7538118 (6), 9208937 (5) (see all 99)
    convulxin 76.2 8 9670039 (2), 10217417 (1), 10942756 (1), 11278467 (1) (see all 6)
    phosphotyrosine 69.1 11 8590001 (1), 10075687 (1), 18689684 (1), 19421152 (1) (see all 11)
    pp55 67.3 1 9195899 (1)
    4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine 64.7 4 14978183 (1), 15107458 (1), 19797620 (1)
    phosphatidylinositol 62.2 25 12477728 (5), 11698498 (3), 9183664 (1), 7831290 (1) (see all 18)
    wortmannin 53.2 7 10586078 (2), 11698498 (1), 16918505 (1), 14699155 (1) (see all 5)
    bis(maltolato)oxovanadium(iv) 52.2 1 7657667 (1)
    phosphoinositide 51.3 14 11331248 (1), 20367574 (1), 12077122 (1), 11907067 (1) (see all 13)

    Search CenterWatch for drugs/clinical trials and news about SYK / KSYK

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SYK gene (4 alternative transcripts): 
    NM_001135052.2  NM_001174167.1  NM_001174168.1  NM_003177.5  

    Unigene Cluster for SYK:

    Spleen tyrosine kinase
    Hs.371720  [show with all ESTs]
    Unigene Representative Sequence: NM_003177
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000375754(uc004aqz.3) ENST00000375751(uc004ara.3) ENST00000375747(uc004arb.3)
    ENST00000476708 ENST00000375746(uc004arc.3 uc011ltt.2 uc011ltr.2 uc011lts.2)

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    hsa-miR-767-3p hsa-miR-2276 hsa-miR-4290 hsa-miR-497* hsa-miR-548c-3p
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    Additional mRNA sequence: 

    AJ420449.1 AK057772.1 AK075020.1 AK290927.1 BC001645.2 BC002962.1 BC011399.1 FN391891.1 
    FN391892.1 FN391893.1 L28824.1 S80267.1 X73568.1 Z29630.1 

    19 DOTS entries:

    DT.113736  DT.100775429  DT.100775428  DT.100736526  DT.86850732  DT.100775425  DT.95161192  DT.87016326 
    DT.95212498  DT.100743088  DT.100651169  DT.100739866  DT.121160422  DT.91994386  DT.95161189  DT.95161195 
    DT.100026638  DT.97815100  DT.91768282 

    24/315 AceView cDNA sequences (see all 315):

    BG675084 BQ223631 BG315206 CF137622 BM542999 W33093 AA279637 BE513917 
    AW575810 CR606511 BU753966 BX482304 T48751 AA810141 AW080011 AW086131 
    CF136975 AA486583 AA878639 AL832053 BE300949 AA035009 BX363732 T92606 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for SYK (see all 10)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a ·
    SP1:                                                        -                                         -                                                         
    SP2:        -     -     -     -     -                       -                                         -                                                         
    SP3:        -     -     -     -     -                       -                                   -     -                                                         
    SP4:                    -     -     -                       -                                   -     -                                                         
    SP5:                                                        -           -     -     -     -     -     -     -     -                                             

    ExUns: 17b · 17c ^ 18
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for SYK

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SYK expression in normal human tissues (normalized intensities)      SYK embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGACTGATCC
    SYK Expression
    About this image


    SYK expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/26 selected tissues (see all 26) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 12 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             Fetal Liver CD36+ Cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Hippocampus
     
     Lymph (Hematopoietic System)    fully expand to see all 3 entries
             lymph node ; non-germinal center cells   
             LYMPH NODE   
     
     Tonsil (Hematopoietic System)    fully expand to see all 3 entries
             tonsil ; squamous epithelial cells   

    See SYK Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SYK

    SOURCE GeneReport for Unigene cluster: Hs.371720

    UniProtKB/Swiss-Prot: KSYK_HUMAN, P43405
    Tissue specificity: Widely expressed in hematopoietic cells (at protein level). Within the B-cells compartment it
    is for instance expressed for pro-B-cells to plasma cells

        SABiosciences Expression via Pathway-Focused PCR Arrays including SYK: 
              Th17 Response in human mouse rat
              Lymphoma in human mouse rat
              Antifungal Response in human mouse rat
              Tumor Metastasis in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYK

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SYK gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Syk1 , 5 spleen tyrosine kinase1, 5 85.43(n)1
    93(a)1
      13 (27.41 cM)5
    209631  NM_001198977.11  NP_001185906.11 
     525831735 
    chicken
    (Gallus gallus)
    Aves SYK1 spleen tyrosine kinase 72.76(n)
    80.56(a)
      427272  NM_001031430.1  NP_001026601.1 
    lizard
    (Anolis carolinensis)
    Reptilia SYK6
    Tyrosine-protein kinase
    74(a)
    1 ↔ 1
    2(32078575-32126403)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC687542 hypothetical protein MGC68754 72.87(n)    BC061936.1 
    zebrafish
    (Danio rerio)
    Actinopterygii syk1 spleen tyrosine kinase 67.3(n)
    71.55(a)
      405769  NM_212843.1  NP_998008.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta shark6
    hop6
    hopscotch
    21(a)
    12(a)
    possible ortholog
    possible ortholog
    2R(12086931-12090388)
    X(11254932-11262130)


    ENSEMBL Gene Tree for SYK (if available)
    TreeFam Gene Tree for SYK (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SYK gene
    TNK12  JAK32  JAK22  TNK22  TYK22  ERBB42  JAK12  ERBB32  
    PTK22  ERBB22  ZAP702  EGFR2  PTK2B2  
    4 SIMAP similar genes for SYK using alignment to 3 protein entries:     KSYK_HUMAN (see all proteins):
    p72syk    ZAP70    EPHA2    PTPN11

    SYK for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2742 SNPs in SYK are shown (see all 2742)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs58991041,2
    C--93566299(+) TTACC-/AAAAAA 3 -- int1 trp30--------
    rs715096641,2
    C--93567237(+) TGAGG-/T/TT  
            
    TTTTT
    3 -- int11NA 2
    rs58991051,2
    C--93567246(+) TTTTT-/T/TT  
            
    CCTTT
    3 -- int1 trp31NA 2
    rs38383361,2
    C--93569179(+) NNNNN-/ATTTTTG
    /ATTTTTGT
    ATTTT
    3 -- int10--------
    rs58991061,2
    C--93569814(+) GGTAC-/CTGGTA 3 -- int11Minor allele frequency- C:0.00CSA 2
    rs105732131,2
    C--93570744(+) GTTGG-/T/TT  
            
    TTTTT
    3 -- int10--------
    rs790952911,2
    C--93572779(+) AACTTG/TGGGGG 3 -- int10--------
    rs1460636361,2
    C--93572885(+) GATAT-/AGGAGA 3 -- int10--------
    rs58991071,2
    C,F--93573351(+) AACTTA/-GGTGA 3 -- int12Minor allele frequency- -:0.50NA 4
    rs759231601,2
    C--93573351(+) AACTTA/G/TGGTGA 3 -- int10--------

    HapMap Linkage Disequilibrium report for SYK (93564012 - 93660842 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/17 variations for SYK (see all 17):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2738748CNV Deletion23290073
    esv2738752CNV Deletion23290073
    esv2738753CNV Deletion23290073
    esv2738750CNV Deletion23290073
    esv2738754CNV Deletion23290073
    esv2664340CNV Deletion23128226
    esv2738749CNV Deletion23290073
    esv2669899CNV Deletion23128226
    esv1404670CNV Insertion17803354
    esv24177CNV Loss19812545

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600085    OMIM disorders: --

    20/65 diseases for SYK (see all 65):    About MalaCards
    zap-70 deficiency    mycobacterium abscessus    cherubism    peripheral t-cell lymphoma
    splenic marginal zone lymphoma    wiskott-aldrich syndrome    lymphedema    allergic rhinitis
    mediastinitis    rhinitis    urticaria    follicular lymphoma
    allergic asthma    burkitt's lymphoma    mantle cell lymphoma    b-cell lymphomas
    human t-cell leukemia virus type 1    cutaneous t cell lymphoma    diffuse large b-cell lymphoma    squamous cell carcinoma of the head and neck

    5 diseases from the University of Copenhagen DISEASES database for SYK:
    Leukemia     Lymphoma     Arthritis     Asthma
    Cherubism

    SYK for disorders           About GeneDecksing

    10/50 Novoseek inferred disease relationships for SYK gene (see all 50)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia lymphocytic chronic 49.7 5 19549911 (1), 19092849 (1), 19965662 (1), 20335218 (1) (see all 5)
    lymphoma b-cell 42.2 9 16912221 (1), 19092849 (1), 19296913 (1), 19965662 (1) (see all 7)
    lymphocytic leukemia chronic b-cell 41.1 6 16912221 (1), 19092849 (1), 19296913 (1), 19144411 (1)
    leukemia b-cell 37.4 2 16912221 (1), 19092849 (1)
    wiskott-aldrich syndrome 34.5 2 16460447 (1), 11313252 (1)
    leukemia basophilic 32.9 3 7513161 (1), 12193692 (1), 14996825 (1)
    lymphoma t-cell peripheral 32.4 1 16341044 (1)
    autoimmune diseases 31.2 13 15212616 (2), 19220318 (1), 17662659 (1), 20013945 (1) (see all 8)
    rheumatoid arthritis 29.9 8 17537677 (2), 18447591 (1), 19530990 (1), 20001666 (1) (see all 6)
    lymphoma 29.8 21 17182546 (5), 20133729 (3), 16670274 (2), 9565626 (1) (see all 10)

    Genetic Association Database (GAD): SYK
    Human Genome Epidemiology (HuGE) Navigator: SYK (3 documents)

    Export disorders for SYK gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SYK gene, integrated from 9 sources (see all 913):
    (articles sorted by number of sources associating them with SYK)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular mechanism of the Syk activation switch. (PubMed id 18818202)1, 2, 9 Tsang E....Bradshaw J.M. (2008)
    2. Phospholipase C-gamma1 interacts with conserved phosphotyrosyl residues in the linker region of Syk and is a substrate for Syk. (PubMed id 8657103)1, 2, 9 Law C.L....Clark E.A. (1996)
    3. Coordinated regulation of the tyrosine phosphorylation of Cbl by Fyn and Syk tyrosine kinases. (PubMed id 9535867)1, 2, 9 Deckert M.... Liu Y.C. (1998)
    4. Molecular cloning of human Syk. A B cell protein-tyrosine kinase associated with the surface immunoglobulin M-B cell receptor complex. (PubMed id 8163536)1, 2, 9 Law C.-L.... Clark E.A. (1994)
    5. Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton. (PubMed id 11940607)1, 2, 9 Obergfell A....Shattil S.J. (2002)
    6. Structural basis for Syk tyrosine kinase ubiquity in signal transduction pathways revealed by the crystal structure of its regulatory SH2 domains bound to a dually phosphorylated ITAM peptide. (PubMed id 9698567)1, 2, 9 Fuetterer K.... Waksman G. (1998)
    7. Integral membrane protein 2 of Epstein-Barr virus regulates reactivation from latency through dominant negative effects on protein-tyrosine kinases. (PubMed id 7895172)1, 2, 9 Miller C.L.... Kieff E. (1995)
    8. Cloning of the cDNA for the deleted syk kinase homologous to ZAP-70 from human basophilic leukemia cell line (KU812). (PubMed id 7513161)1, 2, 9 Yagi S.... Ra C. (1994)
    9. Association of the Src homology 2 domain-containing leukocyte phosphoprotein of 76 kD (SLP-76) with the p85 subunit of phosphoinositide 3-kinase. (PubMed id 15388330)1, 2, 9 Shim E.K....Lee J.R. (2004)
    10. ITAM-based interaction of ERM proteins with Syk mediates signaling by the leukocyte adhesion receptor PSGL-1. (PubMed id 12387735)1, 2, 9 Urzainqui A....Sanchez-Madrid F. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6850 HGNC: 11491 AceView: SYK Ensembl:ENSG00000165025 euGenes: HUgn6850
    ECgene: SYK Kegg: 6850 H-InvDB: SYK

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SYK Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SYK Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SYK gene:
    Search GeneIP for patents involving SYK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

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     Proteins for SYK
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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