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Aliases for SYK Gene

Aliases for SYK Gene

  • Spleen Tyrosine Kinase 2 3 4 5
  • EC 2.7.10.2 4 63
  • P72-Syk 3 4
  • EC 2.7.10 63

External Ids for SYK Gene

Previous GeneCards Identifiers for SYK Gene

  • GC09P084403
  • GC09P085292
  • GC09P086863
  • GC09P088905
  • GC09P090643
  • GC09P092603
  • GC09P093564
  • GC09P063244

Summaries for SYK Gene

Entrez Gene Summary for SYK Gene

  • This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

GeneCards Summary for SYK Gene

SYK (Spleen Tyrosine Kinase) is a Protein Coding gene. Diseases associated with SYK include b cell linker protein deficiency and nasu-hakola disease. Among its related pathways are Platelet activation, signaling and aggregation and Signaling by GPCR. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is TYK2.

UniProtKB/Swiss-Prot for SYK Gene

  • Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the receptor can also be indirect and mediated by adapter proteins containing ITAM or partial hemITAM domains. The phosphorylation of the ITAM domains is generally mediated by SRC subfamily kinases upon engagement of the receptor. More rarely signal transduction via SYK could be ITAM-independent. Direct downstream effectors phosphorylated by SYK include VAV1, PLCG1, PI-3-kinase, LCP2 and BLNK. Initially identified as essential in B-cell receptor (BCR) signaling, it is necessary for the maturation of B-cells most probably at the pro-B to pre-B transition. Activated upon BCR engagement, it phosphorylates and activates BLNK an adapter linking the activated BCR to downstream signaling adapters and effectors. It also phosphorylates and activates PLCG1 and the PKC signaling pathway. It also phosphorylates BTK and regulates its activity in B-cell antigen receptor (BCR)-coupled signaling. In addition to its function downstream of BCR plays also a role in T-cell receptor signaling. Plays also a crucial role in the innate immune response to fungal, bacterial and viral pathogens. It is for instance activated by the membrane lectin CLEC7A. Upon stimulation by fungal proteins, CLEC7A together with SYK activates immune cells inducing the production of ROS. Also activates the inflammasome and NF-kappa-B-mediated transcription of chemokines and cytokines in presence of pathogens. Regulates neutrophil degranulation and phagocytosis through activation of the MAPK signaling cascade. Also mediates the activation of dendritic cells by cell necrosis stimuli. Also involved in mast cells activation. Also functions downstream of receptors mediating cell adhesion. Relays for instance, integrin-mediated neutrophils and macrophages activation and P-selectin receptor/SELPG-mediated recruitment of leukocytes to inflammatory loci. Plays also a role in non-immune processes. It is for instance involved in vascular development where it may regulate blood and lymphatic vascular separation. It is also required for osteoclast development and function. Functions in the activation of platelets by collagen, mediating PLCG2 phosphorylation and activation. May be coupled to the collagen receptor by the ITAM domain-containing FCER1G. Also activated by the membrane lectin CLEC1B that is required for activation of platelets by PDPN/podoplanin. Involved in platelet adhesion being activated by ITGB3 engaged by fibrinogen.

Tocris Summary for SYK Gene

  • Spleen tyrosine kinase (Syk) is a non-receptor cytoplasmic enzyme that is primarily expressed in cells of hematopoietic lineage. Syk contains two adjacent SH2 domains that bind to immunoreceptor tyrosine-based activation motifs (ITAMs) to activate the enzyme.

Gene Wiki entry for SYK Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYK Gene

Genomics for SYK Gene

Regulatory Elements for SYK Gene

Promoters for SYK Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SYK on UCSC Golden Path with GeneCards custom track

Genomic Location for SYK Gene

Chromosome:
9
Start:
90,801,680 bp from pter
End:
90,898,560 bp from pter
Size:
96,881 bases
Orientation:
Plus strand

Genomic View for SYK Gene

Genes around SYK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SYK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SYK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYK Gene

Proteins for SYK Gene

  • Protein details for SYK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P43405-KSYK_HUMAN
    Recommended name:
    Tyrosine-protein kinase SYK
    Protein Accession:
    P43405

    Protein attributes for SYK Gene

    Size:
    635 amino acids
    Molecular mass:
    72066 Da
    Quaternary structure:
    • Interacts with LYN; phosphorylates SYK (By similarity). Interacts with RHOH (phosphorylated); regulates mast cells activation (By similarity). Interacts with NFAM1 (phosphorylated); probably involved in BCR signaling (By similarity). Interacts with VAV1 (via SH2 domain); phosphorylates VAV1 upon BCR activation. Interacts with GAB2 (phosphorylated); probably involved in IgE Fc receptor signaling (By similarity). Interacts (via its SH2 domains) with CD79A (via its phosphorylated ITAM domain); the interaction stimulates SYK autophosphorylation and activation (By similarity). Interacts with FCRL3. Interacts (via SH2 domains) with FCER1G (via ITAM domain); activates SYK and mediates neutrophils and macrophages integrin-mediated activation (By similarity). Interacts with ITGB2 and FGR; involved in ITGB2 downstream signaling (By similarity). Interacts with ITGB3; upon activation by ITGB3 promotes platelet adhesion. Interacts (via SH2 domains) with TYROBP (via ITAM domain); involved in neutrophils and macrophages integrin-mediated activation (By similarity). Interacts with MSN and SELPLG; mediates the selectin-dependent activation of SYK by SELPLG. Interacts with BLNK (via SH2 domain). Interacts (via the second SH2 domain) with USP25 (via C-terminus); phosphorylates USP25 and regulates USP25 intracellular levels. Interacts (via SH2 domains) with CLEC1B (dimer). Interacts with CLEC7A; participates in leukocyte activation in presence of fungal pathogens. Interacts (phosphorylated) with SLA; may regulate SYK through CBL recruitment. Interacts with YWHAG; attenuates BCR-induced membrane translocation and activation of SYK. Interacts with Epstein-Barr virus LMP2A. Interacts (via SH2 domains) with GCSAM; the interaction increases after B-cell receptor stimulation, resulting in enhanced SYK autophosphorylation and activity. Interacts with TNS2; leading to the phosphorylation of SYK (PubMed:22019427). Interacts with FLNA (via filamin repeat 5); docks SYK to the plasma membrane (PubMed:20713593).

    Three dimensional structures from OCA and Proteopedia for SYK Gene

    Alternative splice isoforms for SYK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SYK Gene

Proteomics data for SYK Gene at MOPED

Post-translational modifications for SYK Gene

  • Autophosphorylated. Phosphorylated on tyrosine residues by LYN following receptors engagement. Phosphorylation on Tyr-323 creates a binding site for CBL, an adapter protein that serves as a negative regulator of BCR-stimulated calcium ion signaling. Phosphorylation at Tyr-348 creates a binding site for VAV1. Phosphorylation on Tyr-348 and Tyr-352 enhances the phosphorylation and activation of phospholipase C-gamma and the early phase of calcium ion mobilization via a phosphoinositide 3-kinase-independent pathway (By similarity). Phosphorylation on Ser-297 is very common, it peaks 5 minutes after BCR stimulation, and creates a binding site for YWHAG. Phosphorylation at Tyr-630 creates a binding site for BLNK. Dephosphorylated by PTPN6.
  • Ubiquitinated by CBLB after BCR activation; which promotes proteasomal degradation.
  • Ubiquitination at Lys 517
  • Modification sites at PhosphoSitePlus

Other Protein References for SYK Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SYK (Syk)

Domains & Families for SYK Gene

Gene Families for SYK Gene

Suggested Antigen Peptide Sequences for SYK Gene

Graphical View of Domain Structure for InterPro Entry

P43405

UniProtKB/Swiss-Prot:

KSYK_HUMAN :
  • The SH2 domains mediate the interaction of SYK with the phosphorylated ITAM domains of transmembrane proteins. Some proteins like CLEC1B have a partial ITAM domain (also called hemITAM) containing a single YxxL motif. The interaction with SYK requires CLEC1B homodimerization.
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. SYK/ZAP-70 subfamily.
Domain:
  • The SH2 domains mediate the interaction of SYK with the phosphorylated ITAM domains of transmembrane proteins. Some proteins like CLEC1B have a partial ITAM domain (also called hemITAM) containing a single YxxL motif. The interaction with SYK requires CLEC1B homodimerization.
  • Contains 1 protein kinase domain.
  • Contains 2 SH2 domains.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. SYK/ZAP-70 subfamily.
genes like me logo Genes that share domains with SYK: view

Function for SYK Gene

Molecular function for SYK Gene

GENATLAS Biochemistry:
spleen tyrosine kinase,non SRC family,expressed in B,T and myeloid cells
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Autoinhibited. Intramolecular binding of the interdomains A and B (also called linker region) to parts of the catalytic domain keep the catalytic center in an inactive conformation. The phosphorylation of the interdomains or the binding of the SH2 domains with dually phosphorylated ITAM domains on transmembrane proteins disrupt those intramolecular interactions allowing the kinase domain to adopt an active conformation. The phosphorylation of SYK and of the ITAM domains which is responsible for SYK activation is essentially mediated by SRC subfamily kinases, like LYN, upon transmembrane receptors engagement. May also be negatively regulated by PTPN6 through dephosphorylation. Downstream signaling adapters and intermediates like BLNK or RHOH may mediate positive and/or negative feedback regulation. Negatively regulated by CBL and CBLB through ubiquitination and probable degradation. Phosphorylates SH3BP2 which in turn may regulate SYK through LYN (By similarity).
UniProtKB/Swiss-Prot Function:
Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the receptor can also be indirect and mediated by adapter proteins containing ITAM or partial hemITAM domains. The phosphorylation of the ITAM domains is generally mediated by SRC subfamily kinases upon engagement of the receptor. More rarely signal transduction via SYK could be ITAM-independent. Direct downstream effectors phosphorylated by SYK include VAV1, PLCG1, PI-3-kinase, LCP2 and BLNK. Initially identified as essential in B-cell receptor (BCR) signaling, it is necessary for the maturation of B-cells most probably at the pro-B to pre-B transition. Activated upon BCR engagement, it phosphorylates and activates BLNK an adapter linking the activated BCR to downstream signaling adapters and effectors. It also phosphorylates and activates PLCG1 and the PKC signaling pathway. It also phosphorylates BTK and regulates its activity in B-cell antigen receptor (BCR)-coupled signaling. In addition to its function downstream of BCR plays also a role in T-cell receptor signaling. Plays also a crucial role in the innate immune response to fungal, bacterial and viral pathogens. It is for instance activated by the membrane lectin CLEC7A. Upon stimulation by fungal proteins, CLEC7A together with SYK activates immune cells inducing the production of ROS. Also activates the inflammasome and NF-kappa-B-mediated transcription of chemokines and cytokines in presence of pathogens. Regulates neutrophil degranulation and phagocytosis through activation of the MAPK signaling cascade. Also mediates the activation of dendritic cells by cell necrosis stimuli. Also involved in mast cells activation. Also functions downstream of receptors mediating cell adhesion. Relays for instance, integrin-mediated neutrophils and macrophages activation and P-selectin receptor/SELPG-mediated recruitment of leukocytes to inflammatory loci. Plays also a role in non-immune processes. It is for instance involved in vascular development where it may regulate blood and lymphatic vascular separation. It is also required for osteoclast development and function. Functions in the activation of platelets by collagen, mediating PLCG2 phosphorylation and activation. May be coupled to the collagen receptor by the ITAM domain-containing FCER1G. Also activated by the membrane lectin CLEC1B that is required for activation of platelets by PDPN/podoplanin. Involved in platelet adhesion being activated by ITGB3 engaged by fibrinogen.

Enzyme Numbers (IUBMB) for SYK Gene

Gene Ontology (GO) - Molecular Function for SYK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004713 protein tyrosine kinase activity IEA,TAS --
genes like me logo Genes that share ontologies with SYK: view
genes like me logo Genes that share phenotypes with SYK: view

Animal Models for SYK Gene

MGI Knock Outs for SYK:

Animal Model Products

  • Taconic Biosciences Mouse Models for SYK

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SYK Gene

Localization for SYK Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYK Gene

Cell membrane. Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SYK Gene COMPARTMENTS Subcellular localization image for SYK gene
Compartment Confidence
cytosol 5
nucleus 5
plasma membrane 5
cytoskeleton 2
endosome 2
extracellular 2
lysosome 2
endoplasmic reticulum 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for SYK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019815 B cell receptor complex IEA --
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA --
genes like me logo Genes that share ontologies with SYK: view

Pathways & Interactions for SYK Gene

genes like me logo Genes that share pathways with SYK: view

SIGNOR curated interactions for SYK Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for SYK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0001820 serotonin secretion IEA --
GO:0001945 lymph vessel development ISS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002250 adaptive immune response ISS --
genes like me logo Genes that share ontologies with SYK: view

Drugs & Compounds for SYK Gene

(52) Drugs for SYK Gene - From: Novoseek, DGIdb, ApexBio, Tocris, DrugBank, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nilvadipine Approved Pharma Syk kinase inhibitor; inhibits Abeta production 1
Piceatannol Experimental Pharma p56lck/Syk inhibitor, Inhibits TNF-induced NF-kappaB activation 0
2-{[(1R,2S)-2-aminocyclohexyl]amino}-4-[(3-methylphenyl)amino]pyrimidine-5-carboxamide Experimental Pharma Target 0
2-{2-[(3,5-dimethylphenyl)amino]pyrimidin-4-yl}-N-[(1S)-2-hydroxy-1-methylethyl]-4-methyl-1,3-thiazole-5-carboxamide Experimental Pharma Target 0
6-({5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]pyrimidin-4-yl}amino)-2,2-dimethyl-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one Experimental Pharma Target 0

(46) Additional Compounds for SYK Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ER 27319 maleate
1204480-26-1
genes like me logo Genes that share compounds with SYK: view

Drug Products

Transcripts for SYK Gene

Unigene Clusters for SYK Gene

Spleen tyrosine kinase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SYK Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a ·
SP1: - -
SP2: - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - -
SP5: - - - - - - - - -
SP6:
SP7: - - -
SP8: -
SP9: -
SP10: - -

ExUns: 17b · 17c ^ 18
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: - -
SP9:
SP10:

Relevant External Links for SYK Gene

GeneLoc Exon Structure for
SYK
ECgene alternative splicing isoforms for
SYK

Expression for SYK Gene

mRNA expression in normal human tissues for SYK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SYK Gene

This gene is overexpressed in Whole Blood (x16.4) and Spleen (x4.1).

Protein differential expression in normal tissues from HIPED for SYK Gene

This gene is overexpressed in Peripheral blood mononuclear cells (18.0), Lymph node (14.1), Platelet (7.4), and Blymphocyte (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SYK Gene



SOURCE GeneReport for Unigene cluster for SYK Gene Hs.371720

mRNA Expression by UniProt/SwissProt for SYK Gene

P43405-KSYK_HUMAN
Tissue specificity: Widely expressed in hematopoietic cells (at protein level). Within the B-cells compartment it is for instance expressed for pro-B-cells to plasma cells.
genes like me logo Genes that share expression patterns with SYK: view

Protein tissue co-expression partners for SYK Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for SYK Gene

This gene was present in the common ancestor of animals.

Orthologs for SYK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SYK 36
  • 100 (a)
OneToOne
SYK 35
  • 95.66 (n)
  • 95.06 (a)
cow
(Bos Taurus)
Mammalia SYK 36
  • 92 (a)
OneToOne
SYK 35
  • 88.19 (n)
  • 93.21 (a)
dog
(Canis familiaris)
Mammalia SYK 35
  • 86.45 (n)
  • 92.88 (a)
SYK 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Syk 16
Syk 35
  • 85.43 (n)
  • 93 (a)
Syk 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SYK 36
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Syk 35
  • 84.72 (n)
  • 92.31 (a)
chicken
(Gallus gallus)
Aves SYK 35
  • 72.71 (n)
  • 80.56 (a)
SYK 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SYK 36
  • 75 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68754 35
tropical clawed frog
(Silurana tropicalis)
Amphibia syk 35
  • 67.74 (n)
  • 71.38 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10821 35
zebrafish
(Danio rerio)
Actinopterygii syk 36
  • 72 (a)
OneToOne
syk 35
  • 67.3 (n)
  • 71.55 (a)
fruit fly
(Drosophila melanogaster)
Insecta shark 36
  • 21 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ark-1 36
  • 11 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2657 36
  • 27 (a)
OneToMany
Species with no ortholog for SYK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SYK Gene

ENSEMBL:
Gene Tree for SYK (if available)
TreeFam:
Gene Tree for SYK (if available)

Paralogs for SYK Gene

Paralogs for SYK Gene

(4) SIMAP similar genes for SYK Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SYK: view

Variants for SYK Gene

Sequence variations from dbSNP and Humsavar for SYK Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs16906862 - 90,844,032(+) GAGCC(A/C/G/T)CAACT nc-transcript-variant, reference, missense
rs13559 -- 90,898,027(-) TGGGT(A/G)TGAGA utr-variant-3-prime
rs167078 -- 90,825,400(-) tctag(A/T)tcttt intron-variant
rs188312 -- 90,823,333(+) ttctc(A/G)caaaa intron-variant
rs726756 -- 90,892,949(+) TGGCT(C/T)CCTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SYK Gene

Variant ID Type Subtype PubMed ID
nsv893567 CNV Gain 21882294
nsv831652 CNV Gain 17160897
nsv893568 CNV Loss 21882294
nsv893569 CNV Gain 21882294
esv275555 CNV Gain+Loss 21479260
esv7686 CNV Gain 19470904
esv2738748 CNV Deletion 23290073
esv24177 CNV Loss 19812545
esv2738749 CNV Deletion 23290073
esv2669899 CNV Deletion 23128226
esv1404670 CNV Insertion 17803354
esv2664340 CNV Deletion 23128226
esv2738750 CNV Deletion 23290073
esv2738752 CNV Deletion 23290073
esv2738753 CNV Deletion 23290073
dgv265n6 CNV Loss 16902084
esv2738754 CNV Deletion 23290073

Variation tolerance for SYK Gene

Residual Variation Intolerance Score: 18.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.19; 24.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SYK Gene

HapMap Linkage Disequilibrium report
SYK
Human Gene Mutation Database (HGMD)
SYK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SYK Gene

Disorders for SYK Gene

MalaCards: The human disease database

(12) MalaCards diseases for SYK Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
b cell linker protein deficiency
  • b-cell linker protein deficiency
nasu-hakola disease
  • polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy
mycobacterium abscessus
  • m. abscessus
subcutaneous mycosis
  • subcutaneous fungal disease
intraocular retinoblastoma
  • pediatric intraocular retinoblastoma
- elite association - COSMIC cancer census association via MalaCards
Search SYK in MalaCards View complete list of genes associated with diseases

Relevant External Links for SYK

Genetic Association Database (GAD)
SYK
Human Genome Epidemiology (HuGE) Navigator
SYK
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SYK
genes like me logo Genes that share disorders with SYK: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SYK Gene

Publications for SYK Gene

  1. Molecular mechanism of the Syk activation switch. (PMID: 18818202) Tsang E. … Bradshaw J.M. (J. Biol. Chem. 2008) 3 4 23 67
  2. Syk expression in peripheral blood leukocytes, CD34+ progenitors, and CD34-derived basophils. (PMID: 19889729) Ishmael S.S. … MacGlashan D.W. (J. Leukoc. Biol. 2010) 3 23
  3. Regulation of Syk kinase and FcRbeta expression in human basophils during treatment with omalizumab. (PMID: 20236696) Zaidi A.K. … Macglashan D.W. (J. Allergy Clin. Immunol. 2010) 3 23
  4. Rituximab inhibits B-cell receptor signaling. (PMID: 19965664) Kheirallah S. … Bezombes C. (Blood 2010) 3 23
  5. STAT3 is a substrate of SYK tyrosine kinase in B-lineage leukemia/lymphoma cells exposed to oxidative stress. (PMID: 20133729) Uckun F.M. … Ozer Z. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3 23

Products for SYK Gene

  • Addgene plasmids for SYK

Sources for SYK Gene

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