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Aliases for SYK Gene

Aliases for SYK Gene

  • Spleen Associated Tyrosine Kinase 2 3 5
  • Spleen Tyrosine Kinase 2 3 4
  • EC 2.7.10.2 4 61
  • P72-Syk 3 4
  • Tyrosine-Protein Kinase SYK 3
  • EC 2.7.10 61

External Ids for SYK Gene

Previous GeneCards Identifiers for SYK Gene

  • GC09P084403
  • GC09P085292
  • GC09P086863
  • GC09P088905
  • GC09P090643
  • GC09P092603
  • GC09P093564
  • GC09P063244

Summaries for SYK Gene

Entrez Gene Summary for SYK Gene

  • This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

GeneCards Summary for SYK Gene

SYK (Spleen Associated Tyrosine Kinase) is a Protein Coding gene. Diseases associated with SYK include Hantavirus Pulmonary Syndrome and Mycobacterium Abscessus. Among its related pathways are RET signaling and Fc-GammaR Pathway. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is ZAP70.

UniProtKB/Swiss-Prot for SYK Gene

  • Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the receptor can also be indirect and mediated by adapter proteins containing ITAM or partial hemITAM domains. The phosphorylation of the ITAM domains is generally mediated by SRC subfamily kinases upon engagement of the receptor. More rarely signal transduction via SYK could be ITAM-independent. Direct downstream effectors phosphorylated by SYK include VAV1, PLCG1, PI-3-kinase, LCP2 and BLNK. Initially identified as essential in B-cell receptor (BCR) signaling, it is necessary for the maturation of B-cells most probably at the pro-B to pre-B transition. Activated upon BCR engagement, it phosphorylates and activates BLNK an adapter linking the activated BCR to downstream signaling adapters and effectors. It also phosphorylates and activates PLCG1 and the PKC signaling pathway. It also phosphorylates BTK and regulates its activity in B-cell antigen receptor (BCR)-coupled signaling. In addition to its function downstream of BCR plays also a role in T-cell receptor signaling. Plays also a crucial role in the innate immune response to fungal, bacterial and viral pathogens. It is for instance activated by the membrane lectin CLEC7A. Upon stimulation by fungal proteins, CLEC7A together with SYK activates immune cells inducing the production of ROS. Also activates the inflammasome and NF-kappa-B-mediated transcription of chemokines and cytokines in presence of pathogens. Regulates neutrophil degranulation and phagocytosis through activation of the MAPK signaling cascade. Also mediates the activation of dendritic cells by cell necrosis stimuli. Also involved in mast cells activation. Also functions downstream of receptors mediating cell adhesion. Relays for instance, integrin-mediated neutrophils and macrophages activation and P-selectin receptor/SELPG-mediated recruitment of leukocytes to inflammatory loci. Plays also a role in non-immune processes. It is for instance involved in vascular development where it may regulate blood and lymphatic vascular separation. It is also required for osteoclast development and function. Functions in the activation of platelets by collagen, mediating PLCG2 phosphorylation and activation. May be coupled to the collagen receptor by the ITAM domain-containing FCER1G. Also activated by the membrane lectin CLEC1B that is required for activation of platelets by PDPN/podoplanin. Involved in platelet adhesion being activated by ITGB3 engaged by fibrinogen. Together with CEACAM20, enhances production of the cytokine CXCL8/IL-8 via the NFKB pathway and may thus have a role in the intestinal immune response (By similarity).

Tocris Summary for SYK Gene

  • Spleen tyrosine kinase (Syk) is a non-receptor cytoplasmic enzyme that is primarily expressed in cells of hematopoietic lineage. Syk contains two adjacent SH2 domains that bind to immunoreceptor tyrosine-based activation motifs (ITAMs) to activate the enzyme.

Gene Wiki entry for SYK Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYK Gene

Genomics for SYK Gene

Regulatory Elements for SYK Gene

Enhancers for SYK Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F090806 1.2 Ensembl ENCODE 47.8 +7.0 7040 3.8 ZNF263 ZNF146 CBX3 SMARCA4 MAX CEBPB RELA SYK GC09M090810
GH09F090802 0.5 ENCODE 46 +2.1 2060 5.7 PKNOX1 MLX CREB3L1 ARID4B SIN3A YY1 ZNF143 DEK ZNF263 SP3 SYK GC09M090810
GH09F090769 1.1 Ensembl ENCODE 33.1 -30.5 -30480 3.6 CTCF ZNF687 CEBPB JUNB MNT TBX21 IKZF1 ETV6 SPI1 SYK NFIL3 GC09P090776
GH09F090825 1.1 Ensembl ENCODE 28.1 +26.9 26904 6.0 ELF3 PKNOX1 ARID4B RAD21 ZSCAN9 ZNF48 YY1 RARA SCRT2 ETV6 SYK GC09M090810 PIR33467
GH09F090814 1.2 FANTOM5 Ensembl ENCODE 25.1 +13.6 13634 2.6 HDGF HDAC1 ARNT SIN3A ZNF335 GLIS2 ZNF766 SCRT2 ETV6 SMAD5 SYK GC09M090810 PIR33467
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SYK on UCSC Golden Path with GeneCards custom track

Promoters for SYK Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001472560 1320 3201 PKNOX1 MLX CREB3L1 ARID4B SIN3A YY1 ZNF143 DEK ZNF263 SP3

Genomic Location for SYK Gene

Chromosome:
9
Start:
90,801,680 bp from pter
End:
90,898,560 bp from pter
Size:
96,881 bases
Orientation:
Plus strand

Genomic View for SYK Gene

Genes around SYK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SYK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SYK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYK Gene

Proteins for SYK Gene

  • Protein details for SYK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P43405-KSYK_HUMAN
    Recommended name:
    Tyrosine-protein kinase SYK
    Protein Accession:
    P43405

    Protein attributes for SYK Gene

    Size:
    635 amino acids
    Molecular mass:
    72066 Da
    Quaternary structure:
    • Interacts with LYN; phosphorylates SYK (By similarity). Interacts with RHOH (phosphorylated); regulates mast cells activation (By similarity). Interacts with NFAM1 (phosphorylated); probably involved in BCR signaling (By similarity). Interacts with VAV1 (via SH2 domain); phosphorylates VAV1 upon BCR activation. Interacts with GAB2 (phosphorylated); probably involved in IgE Fc receptor signaling (By similarity). Interacts (via its SH2 domains) with CD79A (via its phosphorylated ITAM domain); the interaction stimulates SYK autophosphorylation and activation (By similarity). Interacts with FCRL3. Interacts (via SH2 domains) with FCER1G (via ITAM domain); activates SYK and mediates neutrophils and macrophages integrin-mediated activation (By similarity). Interacts with ITGB2 and FGR; involved in ITGB2 downstream signaling (By similarity). Interacts with ITGB3; upon activation by ITGB3 promotes platelet adhesion. Interacts (via SH2 domains) with TYROBP (via ITAM domain); involved in neutrophils and macrophages integrin-mediated activation (By similarity). Interacts with MSN and SELPLG; mediates the selectin-dependent activation of SYK by SELPLG. Interacts with BLNK (via SH2 domain). Interacts (via the second SH2 domain) with USP25 (via C-terminus); phosphorylates USP25 and regulates USP25 intracellular levels. Interacts (via SH2 domains) with CLEC1B (dimer). Interacts with CLEC7A; participates in leukocyte activation in presence of fungal pathogens. Interacts (phosphorylated) with SLA; may regulate SYK through CBL recruitment. Interacts with YWHAG; attenuates BCR-induced membrane translocation and activation of SYK. Interacts with Epstein-Barr virus LMP2A. Interacts (via SH2 domains) with GCSAM; the interaction increases after B-cell receptor stimulation, resulting in enhanced SYK autophosphorylation and activity. Interacts with TNS2; leading to the phosphorylation of SYK (PubMed:22019427). Interacts with FLNA (via filamin repeat 5); docks SYK to the plasma membrane (PubMed:20713593). Interacts with CEACAM1; lipopolysaccharide activated neutrophils induce phosphorylation of SYK resulting in the formation of a complex including TLR4 and the phosphorylated form of SYK and CEACAM1, which in turn, recruits PTPN6 that dephosphorylates SYK, reducing the production of reactive oxygen species (ROS) and lysosome disruption, leading to a reduction of the inflammasome activity (By similarity). Interacts (via SH2 domains) with CEACAM20 (phosphorylated form); the interaction further enhances CEACAM20 phosphorylation (By similarity).

    Three dimensional structures from OCA and Proteopedia for SYK Gene

    Alternative splice isoforms for SYK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SYK Gene

Selected DME Specific Peptides for SYK Gene

P43405:
  • LCHYHSQE
  • SSKSDVWSFGVLMWE
  • RDLAARN
  • EKLIATTAHE
  • RKAHHYTIERELNGTYAI
  • QLDNPYIVR
  • SYGQKPY
  • SDVWSFGVLMWE
  • LCWTYDVENRPGF
  • MGMKYLEE
  • AARNVLL
  • DGLLRVLTVPCQKIG
  • KSDVWSFG
  • KWYAPECIN
  • ALEQAIISQ
  • FDTLWQLVEHYSYK
  • HYAKISDFGLSKAL
  • FVHRDLA
  • NFVHRDLAARNVL

Post-translational modifications for SYK Gene

  • Autophosphorylated. Phosphorylated on tyrosine residues by LYN following receptors engagement. Phosphorylation on Tyr-323 creates a binding site for CBL, an adapter protein that serves as a negative regulator of BCR-stimulated calcium ion signaling. Phosphorylation at Tyr-348 creates a binding site for VAV1. Phosphorylation on Tyr-348 and Tyr-352 enhances the phosphorylation and activation of phospholipase C-gamma and the early phase of calcium ion mobilization via a phosphoinositide 3-kinase-independent pathway (By similarity). Phosphorylation on Ser-297 is very common, it peaks 5 minutes after BCR stimulation, and creates a binding site for YWHAG. Phosphorylation at Tyr-630 creates a binding site for BLNK. Dephosphorylated by PTPN6.
  • Ubiquitinated by CBLB after BCR activation; which promotes proteasomal degradation.
  • Ubiquitination at Lys 517
  • Modification sites at PhosphoSitePlus

Domains & Families for SYK Gene

Gene Families for SYK Gene

Suggested Antigen Peptide Sequences for SYK Gene

Graphical View of Domain Structure for InterPro Entry

P43405

UniProtKB/Swiss-Prot:

KSYK_HUMAN :
  • The SH2 domains mediate the interaction of SYK with the phosphorylated ITAM domains of transmembrane proteins. Some proteins like CLEC1B have a partial ITAM domain (also called hemITAM) containing a single YxxL motif. The interaction with SYK requires CLEC1B homodimerization.
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. SYK/ZAP-70 subfamily.
Domain:
  • The SH2 domains mediate the interaction of SYK with the phosphorylated ITAM domains of transmembrane proteins. Some proteins like CLEC1B have a partial ITAM domain (also called hemITAM) containing a single YxxL motif. The interaction with SYK requires CLEC1B homodimerization.
  • Contains 1 protein kinase domain.
  • Contains 2 SH2 domains.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. SYK/ZAP-70 subfamily.
genes like me logo Genes that share domains with SYK: view

Function for SYK Gene

Molecular function for SYK Gene

GENATLAS Biochemistry:
spleen tyrosine kinase,non SRC family,expressed in B,T and myeloid cells
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Autoinhibited. Intramolecular binding of the interdomains A and B (also called linker region) to parts of the catalytic domain keep the catalytic center in an inactive conformation. The phosphorylation of the interdomains or the binding of the SH2 domains with dually phosphorylated ITAM domains on transmembrane proteins disrupt those intramolecular interactions allowing the kinase domain to adopt an active conformation. The phosphorylation of SYK and of the ITAM domains which is responsible for SYK activation is essentially mediated by SRC subfamily kinases, like LYN, upon transmembrane receptors engagement. May also be negatively regulated by PTPN6 through dephosphorylation. Downstream signaling adapters and intermediates like BLNK or RHOH may mediate positive and/or negative feedback regulation. Negatively regulated by CBL and CBLB through ubiquitination and probable degradation. Phosphorylates SH3BP2 which in turn may regulate SYK through LYN (By similarity).
UniProtKB/Swiss-Prot Function:
Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the receptor can also be indirect and mediated by adapter proteins containing ITAM or partial hemITAM domains. The phosphorylation of the ITAM domains is generally mediated by SRC subfamily kinases upon engagement of the receptor. More rarely signal transduction via SYK could be ITAM-independent. Direct downstream effectors phosphorylated by SYK include VAV1, PLCG1, PI-3-kinase, LCP2 and BLNK. Initially identified as essential in B-cell receptor (BCR) signaling, it is necessary for the maturation of B-cells most probably at the pro-B to pre-B transition. Activated upon BCR engagement, it phosphorylates and activates BLNK an adapter linking the activated BCR to downstream signaling adapters and effectors. It also phosphorylates and activates PLCG1 and the PKC signaling pathway. It also phosphorylates BTK and regulates its activity in B-cell antigen receptor (BCR)-coupled signaling. In addition to its function downstream of BCR plays also a role in T-cell receptor signaling. Plays also a crucial role in the innate immune response to fungal, bacterial and viral pathogens. It is for instance activated by the membrane lectin CLEC7A. Upon stimulation by fungal proteins, CLEC7A together with SYK activates immune cells inducing the production of ROS. Also activates the inflammasome and NF-kappa-B-mediated transcription of chemokines and cytokines in presence of pathogens. Regulates neutrophil degranulation and phagocytosis through activation of the MAPK signaling cascade. Also mediates the activation of dendritic cells by cell necrosis stimuli. Also involved in mast cells activation. Also functions downstream of receptors mediating cell adhesion. Relays for instance, integrin-mediated neutrophils and macrophages activation and P-selectin receptor/SELPG-mediated recruitment of leukocytes to inflammatory loci. Plays also a role in non-immune processes. It is for instance involved in vascular development where it may regulate blood and lymphatic vascular separation. It is also required for osteoclast development and function. Functions in the activation of platelets by collagen, mediating PLCG2 phosphorylation and activation. May be coupled to the collagen receptor by the ITAM domain-containing FCER1G. Also activated by the membrane lectin CLEC1B that is required for activation of platelets by PDPN/podoplanin. Involved in platelet adhesion being activated by ITGB3 engaged by fibrinogen. Together with CEACAM20, enhances production of the cytokine CXCL8/IL-8 via the NFKB pathway and may thus have a role in the intestinal immune response (By similarity).

Enzyme Numbers (IUBMB) for SYK Gene

Gene Ontology (GO) - Molecular Function for SYK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity NAS,IDA 12885943
GO:0004674 protein serine/threonine kinase activity IDA 23071339
GO:0004713 protein tyrosine kinase activity TAS --
GO:0004715 non-membrane spanning protein tyrosine kinase activity TAS --
GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity IEA --
genes like me logo Genes that share ontologies with SYK: view
genes like me logo Genes that share phenotypes with SYK: view

Animal Models for SYK Gene

MGI Knock Outs for SYK:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SYK Gene

Localization for SYK Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYK Gene

Cell membrane. Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SYK Gene COMPARTMENTS Subcellular localization image for SYK gene
Compartment Confidence
cytosol 5
nucleus 5
plasma membrane 5
cytoskeleton 2
endosome 2
extracellular 2
lysosome 2
endoplasmic reticulum 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for SYK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 23071339
GO:0005737 cytoplasm IDA 23071339
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SYK: view

Pathways & Interactions for SYK Gene

genes like me logo Genes that share pathways with SYK: view

SIGNOR curated interactions for SYK Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for SYK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity IEA --
GO:0001525 angiogenesis IEA --
GO:0001820 serotonin secretion IEA --
GO:0001945 lymph vessel development ISS --
GO:0002092 positive regulation of receptor internalization IEA --
genes like me logo Genes that share ontologies with SYK: view

Drugs & Compounds for SYK Gene

(60) Drugs for SYK Gene - From: DrugBank, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nilvadipine Approved Pharma Syk kinase inhibitor; inhibits Abeta production 1
Piceatannol Experimental Pharma p56lck/Syk inhibitor, Inhibits TNF-induced NF-kappaB activation 0
2-{[(1R,2S)-2-aminocyclohexyl]amino}-4-[(3-methylphenyl)amino]pyrimidine-5-carboxamide Experimental Pharma Target 0
2-{2-[(3,5-dimethylphenyl)amino]pyrimidin-4-yl}-N-[(1S)-2-hydroxy-1-methylethyl]-4-methyl-1,3-thiazole-5-carboxamide Experimental Pharma Target 0
6-({5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]pyrimidin-4-yl}amino)-2,2-dimethyl-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one Experimental Pharma Target 0

(40) Additional Compounds for SYK Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(4) Tocris Compounds for SYK Gene

Compound Action Cas Number
ER 27319 maleate Selective Syk kinase inhibitor 1204480-26-1
MNS Selective inhibitor of Src and Syk 1485-00-3
Nilvadipine Syk kinase inhibitor; inhibits Abeta production 75530-68-6
Piceatannol Inhibits TNF-induced NF-kappaB activation 10083-24-6

(11) ApexBio Compounds for SYK Gene

Compound Action Cas Number
BAY 61-3606 Syk Inhibitor 732983-37-8
BAY 61-3606 dihydrochloride Syk tyrosine kinase inhibitor 648903-57-5
Cerdulatinib Syk/JAK inhibitor 1198300-79-6
Fostamatinib (R788) Spleen tyrosine kinase (Syk) inhibitor 901119-35-5
GS-9973 1229208-44-9
MNS Inhibitor of Src/Syk tyrosine kinases 1485-00-3
Piceatannol p56lck/Syk inhibitor 10083-24-6
PRT062607 Hydrochloride SYK inhibitor,potent and selective 1370261-97-4
R406 SYK inhibitor,potent and ATP-competitive 841290-81-1
R406 (free base) Syk inhibitor 841290-80-0
R788 Syk inhibitor,ATP competitive and potent 1025687-58-4
genes like me logo Genes that share compounds with SYK: view

Drug Products

Transcripts for SYK Gene

Unigene Clusters for SYK Gene

Spleen tyrosine kinase:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SYK Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a ·
SP1: - -
SP2: - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - -
SP5: - - - - - - - - -
SP6:
SP7: - - -
SP8: -
SP9: -
SP10: - -

ExUns: 17b · 17c ^ 18
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: - -
SP9:
SP10:

Relevant External Links for SYK Gene

GeneLoc Exon Structure for
SYK
ECgene alternative splicing isoforms for
SYK

Expression for SYK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SYK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SYK Gene

This gene is overexpressed in Whole Blood (x16.4) and Spleen (x4.1).

Protein differential expression in normal tissues from HIPED for SYK Gene

This gene is overexpressed in Peripheral blood mononuclear cells (18.0), Lymph node (14.1), Platelet (7.4), and Blymphocyte (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SYK Gene



Protein tissue co-expression partners for SYK Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SYK Gene:

SYK

SOURCE GeneReport for Unigene cluster for SYK Gene:

Hs.371720

mRNA Expression by UniProt/SwissProt for SYK Gene:

P43405-KSYK_HUMAN
Tissue specificity: Widely expressed in hematopoietic cells (at protein level). Within the B-cells compartment it is for instance expressed for pro-B-cells to plasma cells.
genes like me logo Genes that share expression patterns with SYK: view

Primer Products

Orthologs for SYK Gene

This gene was present in the common ancestor of animals.

Orthologs for SYK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SYK 34 35
  • 95.66 (n)
cow
(Bos Taurus)
Mammalia SYK 34 35
  • 88.19 (n)
dog
(Canis familiaris)
Mammalia SYK 34 35
  • 86.45 (n)
mouse
(Mus musculus)
Mammalia Syk 34 16 35
  • 85.43 (n)
rat
(Rattus norvegicus)
Mammalia Syk 34
  • 84.72 (n)
oppossum
(Monodelphis domestica)
Mammalia SYK 35
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves SYK 34 35
  • 72.71 (n)
lizard
(Anolis carolinensis)
Reptilia SYK 35
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia syk 34
  • 67.74 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC68754 34
zebrafish
(Danio rerio)
Actinopterygii syk 34 35
  • 67.3 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10821 34
fruit fly
(Drosophila melanogaster)
Insecta shark 35
  • 21 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ark-1 35
  • 11 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2657 35
  • 27 (a)
OneToMany
Species where no ortholog for SYK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SYK Gene

ENSEMBL:
Gene Tree for SYK (if available)
TreeFam:
Gene Tree for SYK (if available)

Paralogs for SYK Gene

Paralogs for SYK Gene

(4) SIMAP similar genes for SYK Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SYK: view

Variants for SYK Gene

Sequence variations from dbSNP and Humsavar for SYK Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs796052158 Likely benign 90,844,052(+) GCTTC(G/T)CCCTG nc-transcript-variant, reference, missense
rs1000735 -- 90,892,334(-) TCAGA(C/G)ACTGG intron-variant
rs10115164 -- 90,805,005(+) TCTCT(A/T)AAAAG intron-variant
rs10118039 -- 90,815,771(+) ATGTG(C/T)TCGGC intron-variant
rs10119179 -- 90,870,518(+) AAGTT(A/G)TACCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SYK Gene

Variant ID Type Subtype PubMed ID
dgv265n6 CNV deletion 16902084
dgv4479e59 CNV duplication 20981092
dgv7687n100 CNV gain 25217958
esv1404670 CNV insertion 17803354
esv24177 CNV loss 19812545
esv2664340 CNV deletion 23128226
esv2669899 CNV deletion 23128226
esv2738748 CNV deletion 23290073
esv2738749 CNV deletion 23290073
esv2738750 CNV deletion 23290073
esv2738752 CNV deletion 23290073
esv2738753 CNV deletion 23290073
esv2738754 CNV deletion 23290073
esv275555 CNV gain+loss 21479260
esv3545114 CNV deletion 23714750
esv3573290 CNV loss 25503493
esv3576680 CNV gain 25503493
esv3621048 CNV gain 21293372
esv3621051 CNV gain 21293372
esv3621052 CNV gain 21293372
esv3621053 CNV gain 21293372
esv3621054 CNV gain 21293372
esv7686 CNV gain 19470904
nsv1038685 CNV gain 25217958
nsv1046989 CNV gain 25217958
nsv1075661 CNV deletion 25765185
nsv1077561 CNV duplication 25765185
nsv1124447 CNV deletion 24896259
nsv1125970 CNV tandem duplication 24896259
nsv1129054 CNV duplication 24896259
nsv1130179 CNV deletion 24896259
nsv1130609 CNV deletion 24896259
nsv1134926 CNV tandem duplication 24896259
nsv1146213 CNV duplication 26484159
nsv1147832 CNV insertion 26484159
nsv614855 CNV gain 21841781
nsv614856 CNV gain 21841781
nsv831652 CNV gain 17160897
nsv950888 CNV duplication 24416366

Variation tolerance for SYK Gene

Residual Variation Intolerance Score: 18.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.19; 24.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SYK Gene

Human Gene Mutation Database (HGMD)
SYK
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SYK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SYK Gene

Disorders for SYK Gene

MalaCards: The human disease database

(14) MalaCards diseases for SYK Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hantavirus pulmonary syndrome
  • hps
mycobacterium abscessus
  • m. abscessus
b cell linker protein deficiency
  • b-cell linker protein deficiency
peripheral t-cell lymphoma
  • lymphoma t-cell peripheral
nasu-hakola disease
  • polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy
- elite association - COSMIC cancer census association via MalaCards
Search SYK in MalaCards View complete list of genes associated with diseases

Relevant External Links for SYK

Genetic Association Database (GAD)
SYK
Human Genome Epidemiology (HuGE) Navigator
SYK
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SYK
genes like me logo Genes that share disorders with SYK: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SYK Gene

Publications for SYK Gene

  1. Molecular mechanism of the Syk activation switch. (PMID: 18818202) Tsang E. … Bradshaw J.M. (J. Biol. Chem. 2008) 3 4 22 64
  2. The kinase Syk as an adaptor controlling sustained calcium signalling and B-cell development. (PMID: 18369315) Kulathu Y. … Reth M. (EMBO J. 2008) 3 4 22 64
  3. Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton. (PMID: 11940607) Obergfell A. … Shattil S.J. (J. Cell Biol. 2002) 3 4 22 64
  4. ITAM-based interaction of ERM proteins with Syk mediates signaling by the leukocyte adhesion receptor PSGL-1. (PMID: 12387735) Urzainqui A. … Sanchez-Madrid F. (Immunity 2002) 3 4 22 64
  5. Coordinated regulation of the tyrosine phosphorylation of Cbl by Fyn and Syk tyrosine kinases. (PMID: 9535867) Deckert M. … Liu Y.C. (J. Biol. Chem. 1998) 3 4 22 64

Products for SYK Gene

  • Addgene plasmids for SYK

Sources for SYK Gene

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