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SYF2 Gene

protein-coding   GIFtS: 52
GCID: GC01M025548

SYF2 Pre-MRNA-Splicing Factor

(Previous names: CCNDBP1 interactor, SYF2 homolog, RNA splicing factor (S....)
(Previous symbol: CBPIN)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SYF2 Pre-MRNA-Splicing Factor1 2     NTC312
CBPIN1 2 3     fSAP292
CCNDBP1 Interactor1 2     GCIP-Interacting Protein P292
Functional Spliceosome-Associated Protein 291 2     Pre-MRNA-Splicing Factor SYF22
CCNDBP1-interactor2 3     SYF2 Homolog, RNA Splicing Factor2
P292 5     GCIPIP3
SYF2 Homolog, RNA Splicing Factor (S. Cerevisiae)1     p293

External Ids:    HGNC: 198241   Entrez Gene: 259492   Ensembl: ENSG000001176147   OMIM: 6070905   UniProtKB: O959263   

Export aliases for SYF2 gene to outside databases

Previous GC identifers: GC01M025296 GC01M025421 GC01M023802


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SYF2 Gene:
This gene encodes a nuclear protein that interacts with cyclin D-type binding-protein 1, which is thought to be a
cell cycle regulator at the G1/S transition. Alternate transcriptional splice variants, encoding different
isoforms, have been characterized. (provided by RefSeq, Jul 2008)

GeneCards Summary for SYF2 Gene:
SYF2 (SYF2 pre-mRNA-splicing factor) is a protein-coding gene. Diseases associated with SYF2 include malaria.

UniProtKB/Swiss-Prot: SYF2_HUMAN, O95926
Function: May be involved in pre-mRNA splicing (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the SYF2 gene promoter:
         NF-1/L   NF-1   AML1a   Pax-6   CUTL1   IRF-1   Ik-2   POU2F1   POU2F1a   IRF-7A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSYF2 promoter sequence
   Search Chromatin IP Primers for SYF2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SYF2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.11   Ensembl cytogenetic band:  1p36.11   HGNC cytogenetic band: 1p36.11

SYF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SYF2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M025548:  view genomic region     (about GC identifiers)

Start:
25,548,767 bp from pter      End:
25,559,013 bp from pter
Size:
10,247 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SYF2_HUMAN, O95926 (See protein sequence)
Recommended Name: Pre-mRNA-splicing factor SYF2  
Size: 243 amino acids; 28722 Da
Subunit: Identified in the spliceosome C complex. Interacts with CCNDBP1
Sequence caution: Sequence=CAI21417.1; Type=Erroneous gene model prediction;
Secondary accessions: Q5TH73

Explore the universe of human proteins at neXtProt for SYF2: NX_O95926

Explore proteomics data for SYF2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SYF2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_056299.1  NP_997053.1  

    ENSEMBL proteins: 
     ENSP00000236273   ENSP00000346330  

    SYF2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR013260 mRNA_splic_SYF2

    Graphical View of Domain Structure for InterPro Entry O95926

    ProtoNet protein and cluster: O95926

    UniProtKB/Swiss-Prot: SYF2_HUMAN, O95926
    Similarity: Belongs to the SYF2 family


    SYF2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SYF2_HUMAN, O95926
    Function: May be involved in pre-mRNA splicing (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0044822poly(A) RNA binding IDA--
         
    SYF2 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for SYF2:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e  Increased gamma-H2AX phosphory 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Syf2):
     cellular  embryogenesis  mortality/aging 

    SYF2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SYF2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SYF2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SYF2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SYF2

    miRNA
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    miRTarBase miRNAs that target SYF2:
    hsa-mir-16-5p (MIRT031481), hsa-mir-320a (MIRT044386)

    Block miRNA regulation of human, mouse, rat SYF2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SYF2 (see all 9):
    hsa-miR-300 hsa-miR-520d-5p hsa-miR-381 hsa-miR-3653 hsa-miR-513c hsa-miR-3658 hsa-miR-524-5p hsa-miR-376c
    SwitchGear 3'UTR luciferase reporter plasmidSYF2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for SYF2
    Predesigned siRNA for gene silencing in human, mouse, rat SYF2

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): SYF2 (NM_207170)
    Sino Biological Human cDNA Clone for SYF2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SYF2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYF2

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    Browse ESI BIO Cell Lines and PureStem Progenitors for SYF2 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYF2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SYF2_HUMAN, O95926: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS11118353
    GO:0071013catalytic step 2 spliceosome IDA11991638

    SYF2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SYF2 About    
    See pathways by source

    SuperPathContained pathways About
    1Spliceosome
    Spliceosome

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1 Kegg Pathway  (Kegg details for SYF2):
        Spliceosome


    SYF2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SYF2
    Interactions:

        Search GeneGlobe Interaction Network for SYF2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SYF2 (O959263 ENSP000002362734) via UniProtKB, MINT, STRING, and/or I2D (see all 112)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCNDBP1O952733, ENSP000003002134I2D: score=1 STRING: ENSP00000300213
    MCM3P252053, ENSP000002298544I2D: score=1 STRING: ENSP00000229854
    CASP3P425743I2D: score=2 
    CASP8Q147903I2D: score=1 
    RBL1P287493I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000075cell cycle checkpoint ----
    GO:0000398mRNA splicing, via spliceosome IC11991638
    GO:0001701in utero embryonic development IEA--
    GO:0007369gastrulation IEA--
    GO:0048568embryonic organ development IEA--

    SYF2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SYF2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SYF2 gene (2 alternative transcripts): 
    NM_015484.4  NM_207170.3  

    Unigene Cluster for SYF2:

    SYF2 homolog, RNA splicing factor (S. cerevisiae)
    Hs.20013  [show with all ESTs]
    Unigene Representative Sequence: NM_015484
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000236273(uc001bjt.1 uc001bju.1 uc010oeo.1) ENST00000354361
    ENST00000474160 ENST00000476231(uc001bjv.1)
    miRNA
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    Block miRNA regulation of human, mouse, rat SYF2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SYF2 (see all 9):
    hsa-miR-300 hsa-miR-520d-5p hsa-miR-381 hsa-miR-3653 hsa-miR-513c hsa-miR-3658 hsa-miR-524-5p hsa-miR-376c
    SwitchGear 3'UTR luciferase reporter plasmidSYF2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SYF2
    Predesigned siRNA for gene silencing in human, mouse, rat SYF2
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    OriGene ORF clones in mouse, rat for SYF2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SYF2 (NM_207170)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SYF2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYF2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SYF2
    OriGene qSTAR qPCR primer pairs in human, mouse for SYF2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SYF2
      QuantiTect SYBR Green Assays in human, mouse, rat SYF2
      QuantiFast Probe-based Assays in human, mouse, rat SYF2

    Additional mRNA sequence: 

    AF273089.1 AK303582.1 AK314859.1 AL080166.1 BC010862.1 

    7 DOTS entries:

    DT.117301  DT.97785772  DT.91759708  DT.100707976  DT.100792438  DT.86849238  DT.95174656 

    Selected AceView cDNA sequences (see all 255):

    BM693145 BQ009073 BU622889 BQ574844 BQ778612 CA436972 AI401700 CB854589 
    BQ001950 BQ021297 CA389847 AI126914 BF002097 BE786293 H57022 NM_015484 
    BU617376 AA832308 BF057608 AW083731 BG390792 BF448069 AW236015 BE466523 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SYF2    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b
    SP1:              -           -                                             
    SP2:              -           -     -                                       
    SP3:                          -                                             
    SP4:              -                                                         


    ECgene alternative splicing isoforms for SYF2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SYF2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACAGTTCCC
    SYF2 Expression
    About this image


    SYF2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
     
     Kidney (Urinary System)
     
     Uterus (Reproductive System)
     
     Thyroid (Endocrine System)
    SYF2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SYF2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.20013

    UniProtKB/Swiss-Prot: SYF2_HUMAN, O95926
    Tissue specificity: Abundantly expressed in the heart, skeletal muscle and kidney. Expressed at lower level other
    tissues

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYF2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SYF2 gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Syf21 , 5 SYF2 homolog, RNA splicing factor (S. cerevisiae)1, 5 83.61(n)1
    90.91(a)1
      4 (67.15 cM)5
    685921  NM_026780.31  NP_081056.11 
     1349308985 
    chicken
    (Gallus gallus)
    Aves SYF21 SYF2 homolog, RNA splicing factor (S. cerevisiae) 77.96(n)
    84.71(a)
      419593  NM_001257294.1  NP_001244223.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    86(a)
    77(a)
    many → 1
    many → 1
    GL343703.1(105224-108303)
    GL344830.1(3167-4416)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC537402 similar to GCIP-interacting protein p29 77.75(n)    BC041520.1 
    zebrafish
    (Danio rerio)
    Actinopterygii hmzeh00312 hmzeh0031 74.64(n)   321342  CK399076.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG123431 CG12343 57.24(n)
    59.02(a)
      36143  NM_136773.2  NP_610617.1 
    worm
    (Caenorhabditis elegans)
    Secernentea K04G7.111 K04G7.11 57.26(n)
    51.67(a)
      176003  NM_066165.6  NP_498566.3 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G168601 AT2G16860 50.64(n)
    37.5(a)
      816187  NM_127239.3  NP_565396.1 
    rice
    (Oryza sativa)
    Liliopsida Os06g07116001 Os06g0711600 50.56(n)
    41.15(a)
      4342038  NM_001065086.1  NP_001058551.1 


    ENSEMBL Gene Tree for SYF2 (if available)
    TreeFam Gene Tree for SYF2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SYF2 gene

    SYF2 for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for SYF2
    PGOHUM00000248434 PGOHUM00000247754 PGOHUM00000237688 PGOHUM00000236447


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SYF2 (see all 283)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1856326771,2
    --23815099(+) GGAGGA/CTGAGG 2 -- us2k10--------
    rs1865059261,2
    --25548299(+) AAAAAA/GAAAAG 2 -- ds50010--------
    rs75164171,2
    C,F,A,H--25548332(+) acaaaA/Gggaga 2 -- ds500115Minor allele frequency- G:0.19NS EA NA WA CSA 1487
    rs1390699011,2
    --25548388(+) TAATCA/GCCAGT 2 -- ds50010--------
    rs1162923891,2
    C,F--25548457(+) TACCCA/GGTCTG 2 -- ds50011Minor allele frequency- G:0.35WA 118
    rs1156561471,2
    F--25548475(+) GTGGCG/ATGATC 2 -- ds50011Minor allele frequency- A:0.03NA 120
    rs1415597771,2
    --25548524(+) TTCTCC/GTGCCT 2 -- ds50010--------
    rs97305971,2
    C--25548527(+) tcctgC/Actcag 2 -- ds50012Minor allele frequency- A:0.00NA 4
    rs124085661,2
    C,A,H--25548537(+) gcctcC/Gcaaag 2 -- ds50010--------
    rs124077111,2
    C,H--25548546(+) agtgcA/Tgggat 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for SYF2 (25548767 - 25559013 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SYF2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv7187CNV Insertion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SYF2
    DNA2.0 Custom Variant and Variant Library Synthesis for SYF2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607090    OMIM disorders: --

    1 disease for SYF2:    
    About MalaCards
    malaria


    SYF2 for disorders           About GeneDecksing


    Export disorders for SYF2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SYF2 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with SYF2)
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    1. p29, a novel GCIP-interacting protein, localizes in the nucleus. (PubMed id 11118353)1, 2, 3 Chang M.-S.... Yang Y.-C. (Biochem. Biophys. Res. Commun. 2000)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PubMed id 11991638)1, 2 Jurica M.S.... Moore M.J. (RNA 2002)
    5. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    6. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    7. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    8. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    9. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    10. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R.... Peters J.M. (Science 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 25949 HGNC: 19824 AceView: P29 Ensembl:ENSG00000117614 euGenes: HUgn25949
    ECgene: SYF2 Kegg: 25949 H-InvDB: SYF2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SYF2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SYF2 gene:
    Search GeneIP for patents involving SYF2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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