SYF2 Gene
protein-coding GIFtS: 49
GCID: GC01M025548
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SYF2 homolog, RNA splicing factor (S. cerevisiae)(Previous name: CCNDBP1 interactor )
(Previous symbol: CBPIN)
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Aliases
for SYF2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| SYF2 Homolog, RNA Splicing Factor (S. Cerevisiae)1 2 | | P292 5 | | CBPIN1 2 3 | | DKFZp564O20821 | | NTC311 2 | | Functional Spliceosome-Associated Protein 292 | | CCNDBP1 Interactor1 2 | | GCIP-Interacting Protein P292 | | FSAP291 | | Pre-MRNA-Splicing Factor SYF22 | | P292 5 | | GCIPIP3 | | CCNDBP1-Interactor1 | | |
Export aliases for SYF2 gene to outside databasesPrevious GC identifers: GC01M025296 GC01M025421 GC01M023802 |
Summaries
for SYF2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SYF2:
This gene encodes a nuclear protein that interacts with cyclin D-type binding-protein 1, which is thought to be a cellcycle regulator at the G1/S transition. Alternate transcriptional splice variants, encoding different isoforms, havebeen characterized. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: SYF2_HUMAN, O95926Function: May be involved in pre-mRNA splicing (By similarity)
|
Genomic Views
for SYF2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004610.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SYF2 gene promoter:
NF-1/L NF-1 AML1a Pax-6 CUTL1 IRF-1 Ik-2 POU2F1 POU2F1a IRF-7A
Other transcription factors
Search SABiosciences Chromatin IP Primers for SYF2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SYF2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p36.11 Ensembl cytogenetic band: 1p36.11 HGNC cytogenetic band: 1p36.11SYF2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M025548: view genomic region
(about GC identifiers)
Start:
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25,548,764 bp from pter |
End:
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25,559,013 bp from pter |
Size:
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10,250 bases |
Orientation:
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minus strand |
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Proteins
for SYF2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SYF2_HUMAN, O95926 (See
protein sequence)Recommended Name: Pre-mRNA-splicing factor SYF2 Size: 243 amino acids; 28722 Da
Subunit: Identified in the spliceosome C complex. Interacts with CCNDBP1
Subcellular location: Nucleus
Sequence caution: Sequence=CAI21417.1; Type=Erroneous gene model prediction;
Secondary accessions: Q5TH73Explore the universe of human proteins at neXtProt for SYF2: NX_O95926
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O95926
SYF2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_056299.1 NP_997053.1
ENSEMBL proteins: ENSP00000236273 ENSP00000346330
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
SYF2 for ontologies About GeneDecksing
SYF2 Antibody Products:
Assay Products for SYF2: |
Protein
Domains /
Families
for SYF2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SYF2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry O95926ProtoNet protein and cluster: O95926 UniProtKB/Swiss-Prot: SYF2_HUMAN, O95926Similarity: Belongs to the SYF2 family |
Function
for SYF2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SYF2_HUMAN, O95926Function: May be involved in pre-mRNA splicing (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SYF2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SYF2 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): SYF2 (NM_207170) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SYF2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYF2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYF2 |
4 GenomeRNAi human phenotypes for SYF2:
Animal Models:
3 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Syf2):
SYF2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for SYF2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | mRNA Splicing - Major Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Kegg Pathway (Kegg details for SYF2):
SYF2 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SYF2
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
5/8 Interacting proteins for SYF2 (O959263 ENSP000002362734) via UniProtKB, MINT, STRING, and/or I2D (see all 8)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000398 | mRNA splicing, via spliceosome |
IC | 11991638 |
SYF2 for ontologies About GeneDecksing
|
Drugs & Compounds
for SYF2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SYF2
Search CenterWatch for drugs/clinical trials and news about SYF2
|
Transcripts
for SYF2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SYF2 gene (2 alternative transcripts): NM_015484.4 NM_207170.3 Unigene Cluster for SYF2: SYF2 homolog, RNA splicing factor (S. cerevisiae) Hs.20013 [show with all ESTs]Unigene Representative Sequence: NM_0154844 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000236273(uc001bjt.1 uc001bju.1 uc010oeo.1) ENST00000354361
ENST00000474160 ENST00000476231(uc001bjv.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SYF2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SYF2 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): SYF2 (NM_207170) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SYF2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYF2 |
Additional cDNA sequence: AF273089.1 AK303582.1 AK314859.1 AL080166.1 BC010862.1 7 DOTS entries: DT.117301 DT.97785772 DT.91759708 DT.100707976 DT.100792438 DT.86849238 DT.95174656 24/255 AceView cDNA sequences (see all 255): AI401700 CA428430 BQ775334 AW083731 CA426151 BU617376 AI076145 CD366096 BM693145 CA418852 BQ574844 BG390792 AI126914 AW236015 AW590424 BM697473 CD679065 BC015824 BE886709 BU158414 NM_015484 BG036187 AI372958 BQ651403
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for SYF2 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b |
|---|
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| SP1: | | | | | - | | | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | - | | | | - | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP4: | | | | | - | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SYF2
|
Expression
for SYF2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SYF2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TACAGTTCCC
About this image
See SYF2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SYF2
SOURCE GeneReport for Unigene cluster: Hs.20013
UniProtKB/Swiss-Prot: SYF2_HUMAN, O95926Tissue specificity: Abundantly expressed in the heart, skeletal muscle and kidney. Expressed at lower level othertissues
SABiosciences Custom PCR Arrays for SYF2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SYF2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SYF2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SYF2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SYF2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYF2 |
Orthologs
for SYF2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for SYF2 gene from 9/30 species (see all 30) About this table
ENSEMBL Gene Tree for SYF2 (if available)
TreeFam Gene Tree for SYF2 (if available) |
Paralogs
for SYF2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SYF2 gene
SYF2 for paralogs About GeneDecksing
4 Pseudogenes.org Pseudogenes for SYF2
PGOHUM00000248434 PGOHUM00000247754 PGOHUM00000237688 PGOHUM00000236447
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Genomic Variants
for SYF2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SYF2 (25548764 - 25559013 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for SYF2
2 CNVs: 2047 0680 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SYF2 |
|
Disorders
/ Diseases
for SYF2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 SYF2 for disorders About MalaCards
SYF2 for disorders About GeneDecksing
OMIM gene information: 607090
OMIM disorders: --
Export disorders for SYF2 gene to outside databases
|
Publications
for SYF2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SYF2 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with SYF2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- p29, a novel GCIP-interacting protein, localizes in the nucleus. (PubMed id 11118353)1, 2, 3 Chang M.-S.... Yang Y.-C. (2000)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PubMed id 11991638)1, 2 Jurica M.S.... Moore M.J. (2002)
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R....Peters J.M. (2010)
- Silencing of p29 affects DNA damage responses with UV irradiation. (PubMed id 16951160)1 Chu P.C....Chang M.S. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for SYF2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SYF2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SYF2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SYF2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SYF2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SYF2 gene:
Search GeneIP for patents involving SYF2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SYF2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for SYF2 | | OriGene shRNA RFP for SYF2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SYF2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SYF2 | | | OriGene Protein Over-expression Lysate for SYF2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SYF2 | | OriGene 3'-UTR Clone for SYF2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SYF2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SYF2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for SYF2 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SYF2 | | OriGene Custom Protein Services for SYF2 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SYF2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SYF2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SYF2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SYF2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SYF2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SYF2 |
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 |  |  |  | |
| | | | Search Tocris compounds for SYF2 |
| |  |  |  |  | | | | | | Recombinant Protein for SYF2 |
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 | | | SYF2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYF2 |
|  |  |  | | | | ThermoFisher Antibodies for SYF2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYF2 |
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