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Aliases for SYF2 Gene

Aliases for SYF2 Gene

  • SYF2 Pre-MRNA-Splicing Factor 2 3
  • P29 3 4 6
  • Functional Spliceosome-Associated Protein 29 2 3
  • CCNDBP1 Interactor 2 3
  • CCNDBP1-Interactor 3 4
  • CBPIN 3 4
  • SYF2 Homolog, RNA Splicing Factor (S. Cerevisiae) 2
  • SYF2 Homolog, RNA Splicing Factor 3
  • Pre-MRNA-Splicing Factor SYF2 3
  • GCIP-Interacting Protein P29 3
  • FSAP29 3
  • GCIPIP 4
  • NTC31 3

External Ids for SYF2 Gene

Previous HGNC Symbols for SYF2 Gene


Previous GeneCards Identifiers for SYF2 Gene

  • GC01M025296
  • GC01M025421
  • GC01M025548
  • GC01M023802

Summaries for SYF2 Gene

Entrez Gene Summary for SYF2 Gene

  • This gene encodes a nuclear protein that interacts with cyclin D-type binding-protein 1, which is thought to be a cell cycle regulator at the G1/S transition. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for SYF2 Gene

SYF2 (SYF2 Pre-MRNA-Splicing Factor) is a Protein Coding gene. Among its related pathways are Spliceosome.

UniProtKB/Swiss-Prot for SYF2 Gene

  • May be involved in pre-mRNA splicing.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYF2 Gene

Genomics for SYF2 Gene

Regulatory Elements for SYF2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SYF2 Gene

25,222,276 bp from pter
25,232,522 bp from pter
10,247 bases
Minus strand

Genomic View for SYF2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SYF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYF2 Gene

Proteins for SYF2 Gene

  • Protein details for SYF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Pre-mRNA-splicing factor SYF2
    Protein Accession:
    Secondary Accessions:
    • Q5TH73

    Protein attributes for SYF2 Gene

    243 amino acids
    Molecular mass:
    28722 Da
    Quaternary structure:
    • Identified in the spliceosome C complex. Interacts with CCNDBP1.
    • Sequence=CAI21417.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for SYF2 Gene


neXtProt entry for SYF2 Gene

Proteomics data for SYF2 Gene at MOPED

Post-translational modifications for SYF2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SYF2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SYF2 Gene

Domains for SYF2 Gene

Protein Domains for SYF2 Gene


Suggested Antigen Peptide Sequences for SYF2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SYF2 family.
  • Belongs to the SYF2 family.
genes like me logo Genes that share domains with SYF2: view

No data available for Gene Families for SYF2 Gene

Function for SYF2 Gene

Molecular function for SYF2 Gene

UniProtKB/Swiss-Prot Function:
May be involved in pre-mRNA splicing.

Gene Ontology (GO) - Molecular Function for SYF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with SYF2: view
genes like me logo Genes that share phenotypes with SYF2: view

Animal Model Products

miRNA for SYF2 Gene

miRTarBase miRNAs that target SYF2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for SYF2 Gene

Localization for SYF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYF2 Gene

Subcellular locations from

Jensen Localization Image for SYF2 Gene COMPARTMENTS Subcellular localization image for SYF2 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for SYF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 11118353
GO:0071013 catalytic step 2 spliceosome IDA 11991638
genes like me logo Genes that share ontologies with SYF2: view

Pathways for SYF2 Gene

SuperPathways for SYF2 Gene

Superpath Contained pathways
1 Spliceosome
genes like me logo Genes that share pathways with SYF2: view

Pathways by source for SYF2 Gene

1 KEGG pathway for SYF2 Gene

Gene Ontology (GO) - Biological Process for SYF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome IC 11991638
GO:0001701 in utero embryonic development IEA --
GO:0007095 mitotic G2 DNA damage checkpoint IEA --
GO:0007369 gastrulation IEA --
GO:0048568 embryonic organ development IEA --
genes like me logo Genes that share ontologies with SYF2: view

Transcripts for SYF2 Gene

Unigene Clusters for SYF2 Gene

SYF2 homolog, RNA splicing factor (S. cerevisiae):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SYF2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SYF2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b
SP1: - -
SP2: - - -
SP3: -
SP4: -

Relevant External Links for SYF2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SYF2 Gene

mRNA expression in normal human tissues for SYF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for SYF2 Gene

This gene is overexpressed in CD8 Tcells (9.4), Testis (8.7), and Fetal Brain (8.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SYF2 Gene

SOURCE GeneReport for Unigene cluster for SYF2 Gene Hs.20013

mRNA Expression by UniProt/SwissProt for SYF2 Gene

Tissue specificity: Abundantly expressed in the heart, skeletal muscle and kidney. Expressed at lower level other tissues.
genes like me logo Genes that share expressions with SYF2: view

Expression partners for SYF2 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for SYF2 Gene

Orthologs for SYF2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SYF2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SYF2 35
  • 91.49 (n)
  • 94.47 (a)
SYF2 36
  • 94 (a)
(Canis familiaris)
Mammalia SYF2 35
  • 90.91 (n)
  • 94.63 (a)
-- 36
  • 87 (a)
-- 36
  • 93 (a)
(Mus musculus)
Mammalia Syf2 35
  • 83.61 (n)
  • 90.91 (a)
Syf2 16
Syf2 36
  • 90 (a)
(Pan troglodytes)
Mammalia SYF2 35
  • 98.35 (n)
  • 97.12 (a)
SYF2 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Syf2 35
  • 83.4 (n)
  • 91.29 (a)
(Monodelphis domestica)
Mammalia SYF2 36
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia SYF2 36
  • 90 (a)
(Gallus gallus)
Aves SYF2 35
  • 77.96 (n)
  • 84.71 (a)
SYF2 36
  • 79 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 86 (a)
-- 36
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6933 35
syf2 35
  • 73.96 (n)
  • 83.26 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC53740 35
(Danio rerio)
Actinopterygii hmzeh0031 35
syf2 35
  • 70.76 (n)
  • 79.24 (a)
syf2 36
  • 79 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8518 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010515 35
  • 55.25 (n)
  • 53.24 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12343 35
  • 57.24 (n)
  • 59.02 (a)
CG12343 36
  • 56 (a)
(Caenorhabditis elegans)
Secernentea K04G7.11 35
  • 57.26 (n)
  • 51.67 (a)
K04G7.11 36
  • 47 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G16860 35
  • 50.64 (n)
  • 37.5 (a)
(Oryza sativa)
Liliopsida Os06g0711600 35
  • 50.56 (n)
  • 41.15 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU00361 35
  • 42.48 (n)
  • 34.88 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes syf2 35
  • 48.29 (n)
  • 34.11 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10576 36
  • 50 (a)
Species with no ortholog for SYF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SYF2 Gene

Gene Tree for SYF2 (if available)
Gene Tree for SYF2 (if available)

Paralogs for SYF2 Gene Pseudogenes for SYF2 Gene

genes like me logo Genes that share paralogs with SYF2: view

No data available for Paralogs for SYF2 Gene

Variants for SYF2 Gene

Sequence variations from dbSNP and Humsavar for SYF2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs9899 -- 25,223,105(+) TGAAA(G/T)GATAT utr-variant-3-prime
rs942988 -- 25,229,322(-) ACACA(C/T)TTTTC intron-variant
rs1045554 -- 25,223,246(-) GTTTA(C/T)AGAAG utr-variant-3-prime
rs3179809 -- 25,222,681(-) ATTTC(A/T)AACAT utr-variant-3-prime
rs6672228 -- 25,231,661(+) AGTCC(C/T)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SYF2 Gene

Variant ID Type Subtype PubMed ID
nsv7187 CNV Insertion 18451855

Relevant External Links for SYF2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SYF2 Gene

Disorders for SYF2 Gene

No disorders were found for SYF2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for SYF2 Gene

Publications for SYF2 Gene

  1. p29, a novel GCIP-interacting protein, localizes in the nucleus. (PMID: 11118353) Chang M.-S. … Yang Y.-C. (Biochem. Biophys. Res. Commun. 2000) 2 3 4
  2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  3. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PMID: 11991638) Jurica M.S. … Moore M.J. (RNA 2002) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4

Products for SYF2 Gene

Sources for SYF2 Gene

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