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Aliases for SYF2 Gene

Aliases for SYF2 Gene

  • SYF2 Pre-MRNA-Splicing Factor 2 3
  • P29 3 4 6
  • Functional Spliceosome-Associated Protein 29 2 3
  • CCNDBP1 Interactor 2 3
  • CCNDBP1-Interactor 3 4
  • CBPIN 3 4
  • SYF2 Homolog, RNA Splicing Factor (S. Cerevisiae) 2
  • SYF2 Homolog, RNA Splicing Factor 3
  • Pre-MRNA-Splicing Factor SYF2 3
  • GCIP-Interacting Protein P29 3
  • FSAP29 3
  • GCIPIP 4
  • NTC31 3

External Ids for SYF2 Gene

Previous Symbols for SYF2 Gene

  • CBPIN

Summaries for SYF2 Gene

Entrez Gene Summary for SYF2 Gene

  • This gene encodes a nuclear protein that interacts with cyclin D-type binding-protein 1, which is thought to be a cell cycle regulator at the G1/S transition. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for SYF2 Gene

SYF2 (SYF2 Pre-MRNA-Splicing Factor) is a Protein Coding gene. Among its related pathways are Spliceosome.

UniProtKB/Swiss-Prot for SYF2 Gene

  • May be involved in pre-mRNA splicing.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYF2 Gene

Genomics for SYF2 Gene

Genomic Location for SYF2 Gene

Start:
25,222,276 bp from pter
End:
25,232,522 bp from pter
Size:
10,247 bases
Orientation:
Minus strand

Genomic View for SYF2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SYF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYF2 Gene

Regulatory Elements for SYF2 Gene

Proteins for SYF2 Gene

  • Protein details for SYF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95926-SYF2_HUMAN
    Recommended name:
    Pre-mRNA-splicing factor SYF2
    Protein Accession:
    O95926
    Secondary Accessions:
    • Q5TH73

    Protein attributes for SYF2 Gene

    Size:
    243 amino acids
    Molecular mass:
    28722 Da
    Quaternary structure:
    • Identified in the spliceosome C complex. Interacts with CCNDBP1.
    SequenceCaution:
    • Sequence=CAI21417.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for SYF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SYF2 Gene

Proteomics data for SYF2 Gene at MOPED

Post-translational modifications for SYF2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SYF2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SYF2 Gene

Domains for SYF2 Gene

Protein Domains for SYF2 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

SYF2_HUMAN
Family:
  • Belongs to the SYF2 family.:
    • O95926
genes like me logo Genes that share domains with SYF2: view

No data available for Gene Families for SYF2 Gene

Function for SYF2 Gene

Molecular function for SYF2 Gene

UniProtKB/Swiss-Prot Function: May be involved in pre-mRNA splicing.

Gene Ontology (GO) - Molecular Function for SYF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with SYF2: view
genes like me logo Genes that share phenotypes with SYF2: view

miRNA for SYF2 Gene

miRTarBase miRNAs that target SYF2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SYF2 Gene

Localization for SYF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYF2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SYF2 Gene COMPARTMENTS Subcellular localization image for SYF2 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for SYF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 11118353
GO:0071013 catalytic step 2 spliceosome IDA 11991638
genes like me logo Genes that share ontologies with SYF2: view

Pathways for SYF2 Gene

SuperPathways for SYF2 Gene

Superpath Contained pathways
1 Spliceosome
genes like me logo Genes that share pathways with SYF2: view

Pathways by source for SYF2 Gene

1 KEGG pathway for SYF2 Gene

Gene Ontology (GO) - Biological Process for SYF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome IC 11991638
GO:0001701 in utero embryonic development IEA --
GO:0007095 mitotic G2 DNA damage checkpoint IEA --
GO:0007369 gastrulation IEA --
GO:0048568 embryonic organ development IEA --
genes like me logo Genes that share ontologies with SYF2: view

Transcripts for SYF2 Gene

Unigene Clusters for SYF2 Gene

SYF2 homolog, RNA splicing factor (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SYF2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b
SP1: - -
SP2: - - -
SP3: -
SP4: -

Relevant External Links for SYF2 Gene

GeneLoc Exon Structure for
SYF2
ECgene alternative splicing isoforms for
SYF2

Expression for SYF2 Gene

mRNA expression in normal human tissues for SYF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SYF2 Gene

SOURCE GeneReport for Unigene cluster for SYF2 Gene Hs.20013

mRNA Expression by UniProt/SwissProt for SYF2 Gene

O95926-SYF2_HUMAN
Tissue specificity: Abundantly expressed in the heart, skeletal muscle and kidney. Expressed at lower level other tissues.
genes like me logo Genes that share expressions with SYF2: view

Orthologs for SYF2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SYF2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SYF2 36
  • 98.35 (n)
  • 97.12 (a)
SYF2 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SYF2 36
  • 91.49 (n)
  • 94.47 (a)
SYF2 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 37
  • 87 (a)
OneToMany
-- 37
  • 93 (a)
OneToMany
SYF2 36
  • 90.91 (n)
  • 94.63 (a)
mouse
(Mus musculus)
Mammalia Syf2 36
  • 83.61 (n)
  • 90.91 (a)
Syf2 16
Syf2 37
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SYF2 37
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SYF2 37
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Syf2 36
  • 83.4 (n)
  • 91.29 (a)
chicken
(Gallus gallus)
Aves SYF2 36
  • 77.96 (n)
  • 84.71 (a)
SYF2 37
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 86 (a)
OneToMany
-- 37
  • 77 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia MGC53740 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6933 36
syf2 36
  • 73.96 (n)
  • 83.26 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8518 36
zebrafish
(Danio rerio)
Actinopterygii hmzeh0031 36
syf2 36
  • 70.76 (n)
  • 79.24 (a)
syf2 37
  • 79 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010515 36
  • 55.25 (n)
  • 53.24 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12343 36
  • 57.24 (n)
  • 59.02 (a)
CG12343 37
  • 56 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea K04G7.11 36
  • 57.26 (n)
  • 51.67 (a)
K04G7.11 37
  • 47 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G16860 36
  • 50.64 (n)
  • 37.5 (a)
rice
(Oryza sativa)
Liliopsida Os06g0711600 36
  • 50.56 (n)
  • 41.15 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU00361 36
  • 42.48 (n)
  • 34.88 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes syf2 36
  • 48.29 (n)
  • 34.11 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10576 37
  • 50 (a)
OneToOne
Species with no ortholog for SYF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SYF2 Gene

ENSEMBL:
Gene Tree for SYF2 (if available)
TreeFam:
Gene Tree for SYF2 (if available)

Paralogs for SYF2 Gene

Pseudogenes.org Pseudogenes for SYF2 Gene

genes like me logo Genes that share paralogs with SYF2: view

No data available for Paralogs for SYF2 Gene

Variants for SYF2 Gene

Sequence variations from dbSNP and Humsavar for SYF2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs9899 -- 25,223,105(+) TGAAA(G/T)GATAT utr-variant-3-prime
rs942988 -- 25,229,322(-) ACACA(C/T)TTTTC intron-variant
rs1045554 -- 25,223,246(-) GTTTA(C/T)AGAAG utr-variant-3-prime
rs3179809 -- 25,222,681(-) ATTTC(A/T)AACAT utr-variant-3-prime
rs6672228 -- 25,231,661(+) AGTCC(C/T)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SYF2 Gene

Variant ID Type Subtype PubMed ID
nsv7187 CNV Insertion 18451855

Relevant External Links for SYF2 Gene

HapMap Linkage Disequilibrium report
SYF2

Disorders for SYF2 Gene

No disorders were found for SYF2 Gene.

No data available for UniProtKB/Swiss-Prot for SYF2 Gene

Publications for SYF2 Gene

  1. p29, a novel GCIP-interacting protein, localizes in the nucleus. (PMID: 11118353) Chang M.-S. … Yang Y.-C. (Biochem. Biophys. Res. Commun. 2000) 2 3 4
  2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  3. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PMID: 11991638) Jurica M.S. … Moore M.J. (RNA 2002) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4

Products for SYF2 Gene

Sources for SYF2 Gene

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