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Aliases for SYF2 Gene

Aliases for SYF2 Gene

  • SYF2 Pre-MRNA Splicing Factor 2 3
  • Functional Spliceosome-Associated Protein 29 2 3
  • SYF2 Pre-MRNA-Splicing Factor 3 5
  • CCNDBP1 Interactor 2 3
  • CCNDBP1-Interactor 3 4
  • CBPIN 3 4
  • P29 3 4
  • SYF2 Homolog, RNA Splicing Factor (S. Cerevisiae) 2
  • SYF2 Homolog, RNA Splicing Factor 3
  • GCIP-Interacting Protein P29 3
  • FSAP29 3
  • GCIPIP 4
  • NTC31 3

External Ids for SYF2 Gene

Previous HGNC Symbols for SYF2 Gene


Previous GeneCards Identifiers for SYF2 Gene

  • GC01M025296
  • GC01M025421
  • GC01M025548
  • GC01M023802

Summaries for SYF2 Gene

Entrez Gene Summary for SYF2 Gene

  • This gene encodes a nuclear protein that interacts with cyclin D-type binding-protein 1, which is thought to be a cell cycle regulator at the G1/S transition. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for SYF2 Gene

SYF2 (SYF2 Pre-MRNA Splicing Factor) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway. GO annotations related to this gene include poly(A) RNA binding.

UniProtKB/Swiss-Prot for SYF2 Gene

  • May be involved in pre-mRNA splicing.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYF2 Gene

Genomics for SYF2 Gene

Regulatory Elements for SYF2 Gene

Enhancers for SYF2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SYF2 on UCSC Golden Path with GeneCards custom track

Promoters for SYF2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SYF2 on UCSC Golden Path with GeneCards custom track

Genomic Location for SYF2 Gene

25,222,276 bp from pter
25,232,522 bp from pter
10,247 bases
Minus strand

Genomic View for SYF2 Gene

Genes around SYF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SYF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SYF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYF2 Gene

Proteins for SYF2 Gene

  • Protein details for SYF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Pre-mRNA-splicing factor SYF2
    Protein Accession:
    Secondary Accessions:
    • Q5TH73

    Protein attributes for SYF2 Gene

    243 amino acids
    Molecular mass:
    28722 Da
    Quaternary structure:
    • Identified in the spliceosome C complex. Interacts with CCNDBP1.
    • Sequence=CAI21417.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for SYF2 Gene


neXtProt entry for SYF2 Gene

Proteomics data for SYF2 Gene at MOPED

Post-translational modifications for SYF2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SYF2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SYF2 Gene

Domains & Families for SYF2 Gene

Protein Domains for SYF2 Gene


Suggested Antigen Peptide Sequences for SYF2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SYF2 family.
  • Belongs to the SYF2 family.
genes like me logo Genes that share domains with SYF2: view

No data available for Gene Families for SYF2 Gene

Function for SYF2 Gene

Molecular function for SYF2 Gene

UniProtKB/Swiss-Prot Function:
May be involved in pre-mRNA splicing.
genes like me logo Genes that share phenotypes with SYF2: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SYF2 Gene

Localization for SYF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYF2 Gene

Subcellular locations from

Jensen Localization Image for SYF2 Gene COMPARTMENTS Subcellular localization image for SYF2 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for SYF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0071012 catalytic step 1 spliceosome IBA --
GO:0071014 post-mRNA release spliceosomal complex IBA --
genes like me logo Genes that share ontologies with SYF2: view

Pathways & Interactions for SYF2 Gene

SuperPathways for SYF2 Gene

Superpath Contained pathways
1 mRNA Splicing - Major Pathway
genes like me logo Genes that share pathways with SYF2: view

Pathways by source for SYF2 Gene

1 KEGG pathway for SYF2 Gene

Gene Ontology (GO) - Biological Process for SYF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007369 gastrulation IEA --
GO:0008284 positive regulation of cell proliferation IEA --
genes like me logo Genes that share ontologies with SYF2: view

No data available for SIGNOR curated interactions for SYF2 Gene

Drugs & Compounds for SYF2 Gene

No Compound Related Data Available

Transcripts for SYF2 Gene

Unigene Clusters for SYF2 Gene

SYF2 homolog, RNA splicing factor (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SYF2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b
SP1: - -
SP2: - - -
SP3: -
SP4: -

Relevant External Links for SYF2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SYF2 Gene

mRNA expression in normal human tissues for SYF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SYF2 Gene

This gene is overexpressed in CD8 Tcells (9.4), Testis (8.7), and Fetal Brain (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SYF2 Gene

SOURCE GeneReport for Unigene cluster for SYF2 Gene Hs.20013

mRNA Expression by UniProt/SwissProt for SYF2 Gene

Tissue specificity: Abundantly expressed in the heart, skeletal muscle and kidney. Expressed at lower level other tissues.
genes like me logo Genes that share expression patterns with SYF2: view

Protein tissue co-expression partners for SYF2 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for SYF2 Gene

Orthologs for SYF2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SYF2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SYF2 35
  • 91.49 (n)
  • 94.47 (a)
SYF2 36
  • 94 (a)
(Canis familiaris)
Mammalia SYF2 35
  • 90.91 (n)
  • 94.63 (a)
-- 36
  • 87 (a)
-- 36
  • 93 (a)
(Mus musculus)
Mammalia Syf2 35
  • 83.61 (n)
  • 90.91 (a)
Syf2 16
Syf2 36
  • 90 (a)
(Pan troglodytes)
Mammalia SYF2 35
  • 98.35 (n)
  • 97.12 (a)
SYF2 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Syf2 35
  • 83.4 (n)
  • 91.29 (a)
(Monodelphis domestica)
Mammalia SYF2 36
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia SYF2 36
  • 90 (a)
(Gallus gallus)
Aves SYF2 35
  • 77.96 (n)
  • 84.71 (a)
SYF2 36
  • 79 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 86 (a)
-- 36
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6933 35
syf2 35
  • 73.96 (n)
  • 83.26 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC53740 35
(Danio rerio)
Actinopterygii hmzeh0031 35
syf2 35
  • 70.76 (n)
  • 79.24 (a)
syf2 36
  • 79 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8518 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010515 35
  • 55.25 (n)
  • 53.24 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12343 35
  • 57.24 (n)
  • 59.02 (a)
CG12343 36
  • 56 (a)
(Caenorhabditis elegans)
Secernentea K04G7.11 35
  • 57.26 (n)
  • 51.67 (a)
K04G7.11 36
  • 47 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G16860 35
  • 50.64 (n)
  • 37.5 (a)
(Oryza sativa)
Liliopsida Os06g0711600 35
  • 50.56 (n)
  • 41.15 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU00361 35
  • 42.48 (n)
  • 34.88 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes syf2 35
  • 48.29 (n)
  • 34.11 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10576 36
  • 50 (a)
Species with no ortholog for SYF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SYF2 Gene

Gene Tree for SYF2 (if available)
Gene Tree for SYF2 (if available)

Paralogs for SYF2 Gene Pseudogenes for SYF2 Gene

genes like me logo Genes that share paralogs with SYF2: view

No data available for Paralogs for SYF2 Gene

Variants for SYF2 Gene

Sequence variations from dbSNP and Humsavar for SYF2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs35324907 - 25,228,228(+) TTGCC(A/G)CACAT reference, missense
rs9899 -- 25,223,105(+) TGAAA(G/T)GATAT utr-variant-3-prime
rs942988 -- 25,229,322(-) ACACA(C/T)TTTTC intron-variant
rs1045554 -- 25,223,246(-) GTTTA(C/T)AGAAG utr-variant-3-prime
rs3179809 -- 25,222,681(-) ATTTC(A/T)AACAT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SYF2 Gene

Variant ID Type Subtype PubMed ID
nsv7187 CNV Insertion 18451855

Variation tolerance for SYF2 Gene

Residual Variation Intolerance Score: 63.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.32; 53.42% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SYF2 Gene

Disorders for SYF2 Gene

Relevant External Links for SYF2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SYF2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SYF2 Gene

Publications for SYF2 Gene

  1. p29, a novel GCIP-interacting protein, localizes in the nucleus. (PMID: 11118353) Chang M.-S. … Yang Y.-C. (Biochem. Biophys. Res. Commun. 2000) 2 3 4 67
  2. Involvement of p29/SYF2/fSAP29/NTC31 in the progression of NSCLC via modulating cell proliferation. (PMID: 25433998) Liu Y. … Ji L. (Pathol. Res. Pract. 2015) 3
  3. SYF2 is upregulated in human epithelial ovarian cancer and promotes cell proliferation. (PMID: 25623116) Yan S. … Wang Y. (Tumour Biol. 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for SYF2 Gene

Sources for SYF2 Gene