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Aliases for SYDE1 Gene

Aliases for SYDE1 Gene

  • Synapse Defective Rho GTPase Homolog 1 2
  • Synapse Defective 1, Rho GTPase, Homolog 1 (C. Elegans) 2 3 5
  • Synapse Defective Protein 1 Homolog 1 3 4
  • Protein Syd-1 Homolog 1 3 4
  • EC 63
  • EC 63
  • 7h3 3

External Ids for SYDE1 Gene

Previous GeneCards Identifiers for SYDE1 Gene

  • GC19P015080
  • GC19P015218
  • GC19P014786

Summaries for SYDE1 Gene

GeneCards Summary for SYDE1 Gene

SYDE1 (Synapse Defective Rho GTPase Homolog 1) is a Protein Coding gene. Among its related pathways are Signaling by Rho GTPases and Signaling by GPCR. GO annotations related to this gene include GTPase activator activity and protein complex binding. An important paralog of this gene is ABR.

UniProtKB/Swiss-Prot for SYDE1 Gene

  • GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYDE1 Gene

Genomics for SYDE1 Gene

Regulatory Elements for SYDE1 Gene

Enhancers for SYDE1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SYDE1 on UCSC Golden Path with GeneCards custom track

Promoters for SYDE1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SYDE1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SYDE1 Gene

15,107,364 bp from pter
15,114,988 bp from pter
7,625 bases
Plus strand

Genomic View for SYDE1 Gene

Genes around SYDE1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SYDE1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SYDE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYDE1 Gene

Proteins for SYDE1 Gene

  • Protein details for SYDE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Rho GTPase-activating protein SYDE1
    Protein Accession:
    Secondary Accessions:
    • Q7L2I8
    • Q8N6J2
    • Q9H8K4

    Protein attributes for SYDE1 Gene

    735 amino acids
    Molecular mass:
    79793 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SYDE1 Gene


neXtProt entry for SYDE1 Gene

Proteomics data for SYDE1 Gene at MOPED

Selected DME Specific Peptides for SYDE1 Gene

Post-translational modifications for SYDE1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SYDE1 Gene

Domains & Families for SYDE1 Gene

Protein Domains for SYDE1 Gene

Suggested Antigen Peptide Sequences for SYDE1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Rho-GAP domain.
  • Contains 1 Rho-GAP domain.
genes like me logo Genes that share domains with SYDE1: view

No data available for Gene Families for SYDE1 Gene

Function for SYDE1 Gene

Molecular function for SYDE1 Gene

UniProtKB/Swiss-Prot Function:
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.

Enzyme Numbers (IUBMB) for SYDE1 Gene

Phenotypes for SYDE1 Gene

MGI mutant phenotypes for SYDE1:
inferred from 2 alleles
GenomeRNAi human phenotypes for SYDE1:
genes like me logo Genes that share phenotypes with SYDE1: view

Animal Models for SYDE1 Gene

MGI Knock Outs for SYDE1:

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SYDE1 Gene

Localization for SYDE1 Gene

Subcellular locations from

Jensen Localization Image for SYDE1 Gene COMPARTMENTS Subcellular localization image for SYDE1 gene
Compartment Confidence
cytosol 5
golgi apparatus 2
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SYDE1 Gene

Pathways & Interactions for SYDE1 Gene

genes like me logo Genes that share pathways with SYDE1: view

Pathways by source for SYDE1 Gene

Interacting Proteins for SYDE1 Gene

Gene Ontology (GO) - Biological Process for SYDE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with SYDE1: view

No data available for SIGNOR curated interactions for SYDE1 Gene

Drugs & Compounds for SYDE1 Gene

No Compound Related Data Available

Transcripts for SYDE1 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for SYDE1 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9
SP3: -
SP4: -

Relevant External Links for SYDE1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SYDE1 Gene

mRNA expression in normal human tissues for SYDE1 Gene

Protein differential expression in normal tissues from HIPED for SYDE1 Gene

This gene is overexpressed in Placenta (28.3), Tlymphocyte (21.0), and Bone marrow stromal cell (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SYDE1 Gene

SOURCE GeneReport for Unigene cluster for SYDE1 Gene Hs.528701

genes like me logo Genes that share expression patterns with SYDE1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SYDE1 Gene

Orthologs for SYDE1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SYDE1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SYDE1 35
  • 81.42 (n)
  • 84.33 (a)
SYDE1 36
  • 90 (a)
(Canis familiaris)
Mammalia SYDE1 35
  • 87.89 (n)
  • 90.88 (a)
SYDE1 36
  • 91 (a)
(Mus musculus)
Mammalia Syde1 35
  • 82.31 (n)
  • 87.48 (a)
Syde1 16
Syde1 36
  • 87 (a)
(Pan troglodytes)
Mammalia SYDE1 35
  • 99.46 (n)
  • 99.59 (a)
SYDE1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Syde1 35
  • 82.95 (n)
  • 87.07 (a)
(Monodelphis domestica)
Mammalia SYDE1 36
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia SYDE1 36
  • 74 (a)
(Gallus gallus)
Aves SYDE1 35
  • 64.96 (n)
  • 61.49 (a)
SYDE1 36
  • 51 (a)
(Anolis carolinensis)
Reptilia SYDE1 36
  • 52 (a)
(Danio rerio)
Actinopterygii LOC568166 35
  • 58.5 (n)
  • 54.32 (a)
SYDE1 36
  • 40 (a)
fruit fly
(Drosophila melanogaster)
Insecta RhoGAP100F 36
  • 12 (a)
(Caenorhabditis elegans)
Secernentea syd-1 36
  • 15 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BEM2 36
  • 5 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.767 36
  • 28 (a)
Species with no ortholog for SYDE1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SYDE1 Gene

Gene Tree for SYDE1 (if available)
Gene Tree for SYDE1 (if available)

Paralogs for SYDE1 Gene

Paralogs for SYDE1 Gene

(4) SIMAP similar genes for SYDE1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SYDE1: view

Variants for SYDE1 Gene

Sequence variations from dbSNP and Humsavar for SYDE1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_062661 A pancreatic ductal adenocarcinoma sample
rs12977092 -- 15,106,666(+) TACAG(A/G)AGTGA upstream-variant-2KB
rs12980862 -- 15,107,071(+) ACCCA(A/G)GAGAA upstream-variant-2KB
rs71334760 -- 15,105,776(+) CTTGG(C/T)CTCCC upstream-variant-2KB
rs8109071 -- 15,113,414(+) GTTGC(C/G)TAAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SYDE1 Gene

Variant ID Type Subtype PubMed ID
dgv1058e1 CNV Complex 17122850
nsv911130 CNV Loss 21882294
esv34154 CNV Loss 18971310
nsv9668 CNV Gain 18304495

Variation tolerance for SYDE1 Gene

Gene Damage Index Score: 4.28; 62.65% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SYDE1 Gene

Disorders for SYDE1 Gene

Relevant External Links for SYDE1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SYDE1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SYDE1 Gene

Publications for SYDE1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67
  2. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) KA+rlA+ K. … GAPrlich D. (Elife 2015) 3
  3. mSYD1A, a mammalian synapse-defective-1 protein, regulates synaptogenic signaling and vesicle docking. (PMID: 23791195) Wentzel C. … Scheiffele P. (Neuron 2013) 2
  4. Proteins recruited by SH3 domains of Ruk/CIN85 adaptor identified by LC-MS/MS. (PMID: 19531213) Havrylov S. … Redowicz M.J. (Proteome Sci 2009) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for SYDE1 Gene

Sources for SYDE1 Gene