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Aliases for SYDE1 Gene

Aliases for SYDE1 Gene

  • Synapse Defective 1, Rho GTPase, Homolog 1 (C. Elegans) 2 3
  • Synapse Defective Protein 1 Homolog 1 3 4
  • Protein Syd-1 Homolog 1 3 4
  • Rho GTPase-Activating Protein SYDE1 3
  • EC 64
  • EC 64
  • 7h3 3

External Ids for SYDE1 Gene

Summaries for SYDE1 Gene

GeneCards Summary for SYDE1 Gene

SYDE1 (Synapse Defective 1, Rho GTPase, Homolog 1 (C. Elegans)) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Rho GTPase cycle. An important paralog of this gene is ABR.

UniProtKB/Swiss-Prot for SYDE1 Gene

  • GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYDE1 Gene

Genomics for SYDE1 Gene

Genomic Location for SYDE1 Gene

15,107,403 bp from pter
15,114,988 bp from pter
7,586 bases
Plus strand

Genomic View for SYDE1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SYDE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYDE1 Gene

Regulatory Elements for SYDE1 Gene

Proteins for SYDE1 Gene

  • Protein details for SYDE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Rho GTPase-activating protein SYDE1
    Protein Accession:
    Secondary Accessions:
    • Q7L2I8
    • Q8N6J2
    • Q9H8K4

    Protein attributes for SYDE1 Gene

    735 amino acids
    Molecular mass:
    79793 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SYDE1 Gene


neXtProt entry for SYDE1 Gene

Proteomics data for SYDE1 Gene at MOPED

Selected DME Specific Peptides for SYDE1 Gene

Post-translational modifications for SYDE1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SYDE1 Gene

Domains for SYDE1 Gene

Protein Domains for SYDE1 Gene


  • Contains 1 Rho-GAP domain.:
    • Q6ZW31
genes like me logo Genes that share domains with SYDE1: view

No data available for Gene Families for SYDE1 Gene

Function for SYDE1 Gene

Molecular function for SYDE1 Gene

UniProtKB/Swiss-Prot Function: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.

Enzyme Numbers (IUBMB) for SYDE1 Gene

Gene Ontology (GO) - Molecular Function for SYDE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity ISS --
GO:0005515 protein binding --
GO:0032403 protein complex binding IEA --
genes like me logo Genes that share ontologies with SYDE1: view

Phenotypes for SYDE1 Gene

MGI mutant phenotypes for SYDE1:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with SYDE1: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SYDE1 Gene

Localization for SYDE1 Gene

Subcellular locations from

Jensen Localization Image for SYDE1 Gene COMPARTMENTS Subcellular localization image for SYDE1 gene
Compartment Confidence
cytosol 4
golgi apparatus 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SYDE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005829 cytosol TAS --
GO:0044300 cerebellar mossy fiber IEA --
GO:0097060 synaptic membrane IEA --
genes like me logo Genes that share ontologies with SYDE1: view

Pathways for SYDE1 Gene

genes like me logo Genes that share pathways with SYDE1: view

Pathways by source for SYDE1 Gene

Interacting Proteins for SYDE1 Gene

Gene Ontology (GO) - Biological Process for SYDE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007130 synaptonemal complex assembly IEA --
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0016081 synaptic vesicle docking IEA --
GO:0043547 positive regulation of GTPase activity --
genes like me logo Genes that share ontologies with SYDE1: view

Transcripts for SYDE1 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for SYDE1 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9
SP3: -
SP4: -

Relevant External Links for SYDE1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SYDE1 Gene

mRNA expression in normal human tissues for SYDE1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SYDE1 Gene

SOURCE GeneReport for Unigene cluster for SYDE1 Gene Hs.528701

genes like me logo Genes that share expressions with SYDE1: view

Orthologs for SYDE1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SYDE1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SYDE1 36
  • 99.46 (n)
  • 99.59 (a)
SYDE1 37
  • 100 (a)
(Bos Taurus)
Mammalia SYDE1 36
  • 81.42 (n)
  • 84.33 (a)
SYDE1 37
  • 90 (a)
(Canis familiaris)
Mammalia SYDE1 36
  • 87.89 (n)
  • 90.88 (a)
SYDE1 37
  • 91 (a)
(Mus musculus)
Mammalia Syde1 36
  • 82.31 (n)
  • 87.48 (a)
Syde1 16
Syde1 37
  • 87 (a)
(Monodelphis domestica)
Mammalia SYDE1 37
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia SYDE1 37
  • 74 (a)
(Rattus norvegicus)
Mammalia Syde1 36
  • 82.95 (n)
  • 87.07 (a)
(Gallus gallus)
Aves SYDE1 36
  • 64.96 (n)
  • 61.49 (a)
SYDE1 37
  • 51 (a)
(Anolis carolinensis)
Reptilia SYDE1 37
  • 52 (a)
(Danio rerio)
Actinopterygii LOC568166 36
  • 58.5 (n)
  • 54.32 (a)
SYDE1 37
  • 40 (a)
fruit fly
(Drosophila melanogaster)
Insecta RhoGAP100F 37
  • 12 (a)
(Caenorhabditis elegans)
Secernentea syd-1 37
  • 15 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BEM2 37
  • 5 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.767 37
  • 28 (a)
Species with no ortholog for SYDE1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SYDE1 Gene

Gene Tree for SYDE1 (if available)
Gene Tree for SYDE1 (if available)

Paralogs for SYDE1 Gene

Paralogs for SYDE1 Gene

Selected SIMAP similar genes for SYDE1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SYDE1: view

Variants for SYDE1 Gene

Sequence variations from dbSNP and Humsavar for SYDE1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs12359 -- 15,114,445(+) GCACT(C/G)TTTGT utr-variant-3-prime
rs2040858 -- 15,111,617(+) AGGGG(A/G)CCCTG intron-variant
rs2240297 -- 15,110,039(+) GTCCC(A/G)CAGCC missense, reference
rs2240298 -- 15,111,876(+) GAGAT(A/G)GGCAT intron-variant
rs2886739 -- 15,105,367(-) tgtcc(A/T)taacc upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SYDE1 Gene

Variant ID Type Subtype PubMed ID
dgv1058e1 CNV Complex 17122850
nsv911130 CNV Loss 21882294
esv34154 CNV Loss 18971310
nsv9668 CNV Gain 18304495

Relevant External Links for SYDE1 Gene

HapMap Linkage Disequilibrium report

Disorders for SYDE1 Gene

No disorders were found for SYDE1 Gene.

No data available for UniProtKB/Swiss-Prot for SYDE1 Gene

Publications for SYDE1 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Proteins recruited by SH3 domains of Ruk/CIN85 adaptor identified by LC-MS/MS. (PMID: 19531213) Havrylov S. … Redowicz M.J. (Proteome Sci 2009) 3
  4. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for SYDE1 Gene

Sources for SYDE1 Gene

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