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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SYDE1 Gene

protein-coding GIFtS: 50
GCID: GC19P015218

synapse defective 1, Rho GTPase, homolog 1 (C. elegans)

Explore 3 diseases affiliated with
SYDE1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Synapse Defective 1, Rho GTPase, Homolog 1 (C. Elegans)¹ ²		FLJ13511¹
7h3¹ ²		Rho GTPase-Activating Protein SYDE1²
Protein Syd-1 Homolog 1² ³		EC 2.4.1.25⁸
Synapse Defective Protein 1 Homolog 1² ³		EC 2.6.1.9⁸

External Ids:	HGNC: 25824¹	Entrez Gene: 85360²	Ensembl: ENSG00000105137⁷	UniProtKB: Q6ZW31³

Export aliases for SYDE1 gene to outside databases

Previous GC identifers: GC19P015080 GC19P014786

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: SYDE1_HUMAN, Q6ZW31

Function: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011295.11

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SYDE1 gene promoter:
USF1 GATA-3 Tal-1 Sp1 NRSF form 1 NRSF form 2 E47 GATA-1 RORalpha1 USF-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SYDE1 promoter sequence

Search SABiosciences Chromatin IP Primers for SYDE1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SYDE1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.12 Ensembl cytogenetic band: 19p13.12 HGNC cytogenetic band: 19p13.12

SYDE1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SYDE1 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P015218: view genomic region (about GC identifiers)

Start:	15,218,214 bp from pter	End:	15,225,789 bp from pter
Size:	7,576 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SYDE1_HUMAN, Q6ZW31 (See protein sequence)

Recommended Name: Rho GTPase-activating protein SYDE1

Size: 735 amino acids; 79793 Da

Secondary accessions: Q7L2I8 Q8N6J2 Q9H8K4

Alternative splicing: 2 isoforms: Q6ZW31-1 Q6ZW31-2

Explore the universe of human proteins at neXtProt for SYDE1: NX_Q6ZW31

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q6ZW31

2 DME Specific Peptides for SYDE1 (Q6ZW31)

DFLRLDH

YGLGGLR

SYDE1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_149014.3

ENSEMBL proteins:

ENSP00000341489

Reactome Protein details: Q6ZW31
Human Recombinant Protein Products for SYDE1:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Novus Biologicals SYDE1 Protein Novus Biologicals SYDE1 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SYDE1

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005829	cytosol	TAS	--

SYDE1 for ontologies About GeneDecksing

SYDE1 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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	Novus Biologicals SYDE1 Antibodies
	Abcam antibodies for SYDE1
	Uscn Antibodies for SYDE1
	Search ThermoFisher Antibodies for SYDE1

Assay Products for SYDE1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for SYDE1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for SYDE1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SYDE1 for domains About GeneDecksing

3 InterPro domains/families:

IPR008973 C2_Ca/lipid-bd_dom_CaLB

IPR008936 Rho_GTPase_activation_prot

IPR000198 RhoGAP_dom

Graphical View of Domain Structure for InterPro Entry Q6ZW31

ProtoNet protein and cluster: Q6ZW31

1 Blocks protein family: IPB000198 RhoGAP domain

UniProtKB/Swiss-Prot: SYDE1_HUMAN, Q6ZW31

Similarity: Contains 1 Rho-GAP domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: SYDE1_HUMAN, Q6ZW31

Function: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By similarity)

Enzyme Numbers (IUBMB): EC 2.6.1.9² EC 2.4.1.25²

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005100	Rho GTPase activator activity	ISS	--

SYDE1 for ontologies About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SYDE1

miRNA Products:		OriGene 3'-UTR Clone: SYDE1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SYDE1
		8/41 QIAGEN miScript miRNA Assays for microRNAs that regulate SYDE1 (see all 41):
		hsa-miR-582-3p hsa-miR-520e hsa-miR-302d hsa-miR-136 hsa-miR-429 hsa-miR-15a hsa-miR-3678-5p hsa-miR-128

		SwitchGear 3'UTR luciferase reporter plasmid: SYDE1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SYDE1 OriGene shRNA RFP: SYDE1 OriGene siRNA: SYDE1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SYDE1
		Sirion Biotech Custom design and validation of potent shRNA sequences against SYDE1

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for SYDE1
			Sirion Biotech Customized adenovirus for overexpression of SYDE1 Sirion Biotech Customized adenovirus for potent knockdown of SYDE1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SYDE1 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SYDE1 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SYDE1 (NM_033025)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SYDE1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYDE1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SYDE1
		Search LifeMap BioReagents cell lines for SYDE1
		Sirion Biotech Customized stable knockdown cell line services for SYDE1 Sirion Biotech Customized inducible knockdown cell line services for SYDE1 Sirion Biotech Customized stable overexpressing cell line services for SYDE1 Sirion Biotech Customized inducible overexpressing cell line services for SYDE1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYDE1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Cell death signalling via NRAGE, NRIF and NADE

Signaling by Rho GTPases

0.25

Rho GTPase cycle

0.25

Signaling by GPCR

Signal Transduction

0.56

Pathway sources
See GeneCards unified pathways
Show all pathways

3 Reactome Pathways for SYDE1

	Signaling by Rho GTPases
	Signal Transduction
	Rho GTPase cycle

SYDE1 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SYDE1

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

2 Interacting proteins for SYDE1 (Q6ZW31³ ENSP00000341489⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
KAT2A	Q92830³	I2D: score=1
SH3KBP1	ENSP00000380921⁴	STRING: ENSP00000380921

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007264	small GTPase mediated signal transduction	TAS	--
GO:0032862	activation of Rho GTPase activity	ISS	--
GO:0051056	regulation of small GTPase mediated signal transduction	TAS	--

SYDE1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SYDE1
Search CenterWatch for drugs/clinical trials and news about SYDE1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SYDE1 gene:

NM_033025.4

Unigene Clusters for SYDE1:

Synapse defective 1, Rho GTPase, homolog 1 (C. elegans)

Hs.528701 [show with all ESTs], Hs.706845

Unigene Representative Sequences: AK128870, AF209931

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000342784(uc002nah.1 uc002nai.1 uc002naj.1)

miRNA Products:		OriGene 3'-UTR Clone: SYDE1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SYDE1
		8/41 QIAGEN miScript miRNA Assays for microRNAs that regulate SYDE1 (see all 41):
		hsa-miR-582-3p hsa-miR-520e hsa-miR-302d hsa-miR-136 hsa-miR-429 hsa-miR-15a hsa-miR-3678-5p hsa-miR-128

		SwitchGear 3'UTR luciferase reporter plasmid: SYDE1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SYDE1 OriGene shRNA RFP: SYDE1 OriGene siRNA: SYDE1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SYDE1
		Sirion Biotech Custom design and validation of potent shRNA sequences against SYDE1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SYDE1 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SYDE1 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SYDE1 (NM_033025)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SYDE1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYDE1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SYDE1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SYDE1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SYDE1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SYDE1

Additional cDNA sequence: AF209931.1

7 DOTS entries:

DT.102829576 DT.97840367 DT.99983997 DT.92423261 DT.100687945 DT.121420810 DT.92414134

24/133 AceView cDNA sequences (see all 133):

BE383218 BU166010 BM471755 BM916657 AA031652 AI468730 AA336131 AW304767

BQ772813 BC029926 AW952588 CA397878 AI521921 BF339476 BU169236 AK023573

BU508752 CA427611 AF209931 AI192799 BM972074 AI031701 AI911408 BI061524

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for SYDE1 (see all 6) About this scheme

ExUns:	1	^	2a	·	2b	^	3a	·	3b	·	3c	^	4	^	5a	·	5b	^	6	^	7	^	8	^	9
SP1:
SP2:
SP3:			-
SP4:																					-
SP5:

ECgene alternative splicing isoforms for SYDE1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SYDE1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTGTATGTG

About this image

SYDE1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Definitive endoderm-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SYDE1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SYDE1

SOURCE GeneReport for Unigene clusters: Hs.528701 Hs.706845

SABiosciences Custom PCR Arrays for SYDE1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SYDE1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SYDE1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SYDE1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SYDE1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYDE1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for SYDE1 gene from 5/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	LOC429892¹	rho GTPase-activating protein SYDE1-like	63.85(n) 59.46(a)		429892 XM_427446.3 XP_427446.3
lizard (Anolis carolinensis)	Reptilia	SYDE1⁶	--	58(a)	1 ↔ 1	2(80126935-80142585)
zebrafish (Danio rerio)	Actinopterygii	LOC568166¹	rho GTPase-activating protein SYDE2-like	59.56(n) 56.21(a)		568166 XM_691479.5 XP_696571.5
fruit fly (Drosophila melanogaster)	Insecta	RhoGAP100F⁶	RhoGAP100F	9(a)	1 → many	3R(27638331-27670966)
worm (Caenorhabditis elegans)	Secernentea	syd-1⁶	Rho GTPase-activating protein syd-1	14(a)	1 → many	II(7585683-7594864)

ENSEMBL Gene Tree for SYDE1 (if available)
TreeFam Gene Tree for SYDE1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SYDE1 gene

RACGAP1² SYDE2² ABR² BCR²

2 SIMAP similar genes for SYDE1 using alignment to 4 protein entries: SYDE1_HUMAN (see all proteins):

ARHGAP12 ARHGAP9

SYDE1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs189954906^1,2		--	15216275(+)	`TACTTC/GGTAGG`	1	--	us2k¹		0	--	--	--	--
rs12459446^1,2	C,F,A,H	--	15216344(+)	`ttttgA/Tttttt`	1	--	us2k¹		3		NA	6
rs183317442^1,2		--	15216427(+)	`CTCCCA/GGGTTC`	1	--	us2k¹		0	--	--	--	--
rs186555234^1,2		--	15216526(+)	`AGGGGA/TTTCCC`	1	--	us2k¹		0	--	--	--	--
rs71334760^1,2	C,F	--	15216587(+)	`CTTGGC/TCTCCC`	1	--	us2k¹		2		NA	4
rs191812861^1,2		--	15216622(+)	`GCCACC/GGCACC`	1	--	us2k¹		0	--	--	--	--
rs144325261^1,2		--	15216639(+)	`AGCCCA/CGGAGT`	1	--	us2k¹		0	--	--	--	--
rs115014257^1,2	F	--	15216698(+)	`AGGGAA/TATTAG`	1	--	us2k¹		1		WA	118
rs56302708^1,2	C,F	--	15216947(+)	`TAGGTG/AGATAA`	1	--	us2k¹		5		NA CSA WA EA	362
rs148779055^1,2		--	15217023(+)	`AGTCAC/TTTATG`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SYDE1 (15218214 - 15225789 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for SYDE1
3 CNVs: 30889 4068 47932

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SYDE1

DNA2.0 Custom Variant and Variant Library Synthesis for SYDE1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SYDE1 for disorders About GeneDecksing

3 diseases for SYDE1: About MalaCards

pancreatic cancer pancreatitis neuronitis

Export disorders for SYDE1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SYDE1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SYDE1)

Utopia: connect your pdf to the dynamic
world of online information

Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{1, 3} Strausberg R.L....Marra M.A. (2002)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)
Proteins recruited by SH3 domains of Ruk/CIN85 adaptor identified by LC-MS/MS. (PubMed id 19531213)¹ Havrylov S....Redowicz M.J. (2009)
A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)² Dephoure N.... Gygi S.P. (2008)
Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. (PubMed id 18772397)² Jones S.... Kinzler K.W. (2008)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 85360	HGNC: 25824	AceView: 7h3	Ensembl:ENSG00000105137	euGenes: HUgn85360
ECgene: SYDE1	H-InvDB: SYDE1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SYDE1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SYDE1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SYDE1 gene:
Search GeneIP for patents involving SYDE1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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	Browse OriGene Antibodies		OriGene shRNA RFP for SYDE1
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SYDE1		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SYDE1
	OriGene Protein Over-expression Lysate for SYDE1		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for SYDE1		OriGene 3'-UTR Clone for SYDE1
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SYDE1		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SYDE1
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for SYDE1		OriGene Custom Protein Services for SYDE1
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SYDE1
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SYDE1
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SYDE1
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SYDE1
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SYDE1
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SYDE1

	GenScript Custom Purified and Recombinant Proteins Services for SYDE1		GenScript cDNA clones with any tag delivered in your preferred vector for SYDE1
	GenScript Custom Assay Services for SYDE1		GenScript Custom Superior Antibodies Services for SYDE1
	GenScript Custom overexpressing Cell Line Services for SYDE1		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
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	Regulatory tfbs in SYDE1 promoter
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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
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	Antibodies for SYDE1
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SYDE1 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for SYDE1

	Gene Synthesis
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYDE1

	SwitchGear 3'UTR luciferase reporter plasmids for SYDE1
	SwitchGear Promoter luciferase reporter plasmids for SYDE1

Search ThermoFisher Antibodies for SYDE1

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYDE1

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SYDE1

Sirion Biotech Customized:

	stable knockdown cell line services for SYDE1
	inducible knockdown cell line services for SYDE1
	design and validation of potent shRNA sequences against SYDE1
	adenovirus for potent knockdown of SYDE1
	adenovirus for overexpression of SYDE1
	stable overexpressing cell line services for SYDE1
	inducible overexpressing cell line services for SYDE1

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes SYDE1 gene at Home site.

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SYDE1 Gene

synapse defective 1, Rho GTPase, homolog 1 (C. elegans)

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SYDE1 Gene

synapse defective 1, Rho GTPase, homolog 1 (C. elegans)

Aliasesfor SYDE1 gene

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Protein Domains /Familiesfor SYDE1 gene

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Genome Databases showing SYDE1 gene

Other Databases showing SYDE1 gene

Specialized Databases showing SYDE1 gene

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for SYDE1 gene

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for SYDE1 gene

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Families
for SYDE1 gene

Function
for SYDE1 gene

Pathways & Interactions
for SYDE1 gene

Drugs & Compounds
for SYDE1 gene

Transcripts
for SYDE1 gene

Expression
for SYDE1 gene

Orthologs
for SYDE1 gene

Paralogs
for SYDE1 gene

Genomic Variants
for SYDE1 gene

Disorders / Diseases
for SYDE1 gene

Publications
for SYDE1 gene

Intellectual Property
for SYDE1 gene

Products
for SYDE1 gene