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Aliases for SYCP3 Gene

Aliases for SYCP3 Gene

  • Synaptonemal Complex Protein 3 2 3 5
  • SCP3 3 4
  • RPRGL4 3
  • SPGF4 3
  • SCP-3 4
  • COR1 3

External Ids for SYCP3 Gene

Previous GeneCards Identifiers for SYCP3 Gene

  • GC12U990147
  • GC12M102105
  • GC12M100624
  • GC12M099182

Summaries for SYCP3 Gene

Entrez Gene Summary for SYCP3 Gene

  • This gene encodes an essential structural component of the synaptonemal complex. This complex is involved in synapsis, recombination and segregation of meiotic chromosomes. Mutations in this gene are associated with azoospermia in males and susceptibility to pregnancy loss in females. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, May 2010]

GeneCards Summary for SYCP3 Gene

SYCP3 (Synaptonemal Complex Protein 3) is a Protein Coding gene. Diseases associated with SYCP3 include spermatogenic failure 4 and sycp3-related pregnancy loss, susceptibility to. Among its related pathways are Cell Cycle, Mitotic and Packaging Of Telomere Ends.

UniProtKB/Swiss-Prot for SYCP3 Gene

  • Component of the synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Required for centromere pairing during meiosis in male germ cells (By similarity). Required for normal meiosis during spermatogenesis and male fertility (PubMed:14643120). Plays a lesser role in female fertility. Required for efficient phosphorylation of HORMAD1 and HORMAD2 (By similarity).

Gene Wiki entry for SYCP3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYCP3 Gene

Genomics for SYCP3 Gene

Regulatory Elements for SYCP3 Gene

Genomic Location for SYCP3 Gene

Chromosome:
12
Start:
101,728,648 bp from pter
End:
101,739,513 bp from pter
Size:
10,866 bases
Orientation:
Minus strand

Genomic View for SYCP3 Gene

Genes around SYCP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SYCP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SYCP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYCP3 Gene

Proteins for SYCP3 Gene

  • Protein details for SYCP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZU3-SYCP3_HUMAN
    Recommended name:
    Synaptonemal complex protein 3
    Protein Accession:
    Q8IZU3

    Protein attributes for SYCP3 Gene

    Size:
    236 amino acids
    Molecular mass:
    27729 Da
    Quaternary structure:
    • Component of the lateral elements of synaptonemal complexes (By similarity). Homotetramer; the tetrameric helix bundles assemble end to end into long homopolimeric fibers that exhibit a transversal striation with a periodicity of about 20 nm (in vitro) (PubMed:24950965). Interacts with SYCP2 (By similarity).

    Three dimensional structures from OCA and Proteopedia for SYCP3 Gene

neXtProt entry for SYCP3 Gene

Proteomics data for SYCP3 Gene at MOPED

Post-translational modifications for SYCP3 Gene

Other Protein References for SYCP3 Gene

Antibody Products

No data available for DME Specific Peptides for SYCP3 Gene

Domains & Families for SYCP3 Gene

Protein Domains for SYCP3 Gene

Suggested Antigen Peptide Sequences for SYCP3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IZU3

UniProtKB/Swiss-Prot:

SYCP3_HUMAN :
  • Composed of a long central coiled coil domain. The N-terminal and C-terminal regions interact with DNA.
  • Belongs to the XLR/SYCP3 family.
Domain:
  • Composed of a long central coiled coil domain. The N-terminal and C-terminal regions interact with DNA.
Family:
  • Belongs to the XLR/SYCP3 family.
genes like me logo Genes that share domains with SYCP3: view

No data available for Gene Families for SYCP3 Gene

Function for SYCP3 Gene

Molecular function for SYCP3 Gene

UniProtKB/Swiss-Prot Function:
Component of the synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Required for centromere pairing during meiosis in male germ cells (By similarity). Required for normal meiosis during spermatogenesis and male fertility (PubMed:14643120). Plays a lesser role in female fertility. Required for efficient phosphorylation of HORMAD1 and HORMAD2 (By similarity).
genes like me logo Genes that share phenotypes with SYCP3: view

Human Phenotype Ontology for SYCP3 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for SYCP3 Gene

MGI Knock Outs for SYCP3:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , miRNA , Transcription Factor Targets and HOMER Transcription for SYCP3 Gene

Localization for SYCP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYCP3 Gene

Nucleus. Chromosome. Chromosome, centromere. Note=It is present in early unpaired cores, in the lateral domains of the synaptonemal complex and in the chromosome cores when they separate at diplotene. It is found axial to the metaphase I chromosomes and in association with pairs of sister centromeres. The centromere-associated protein becomes dissociated from the centromeres at anaphase II and is not found in mitotic metaphase centromeres. {ECO:0000250 UniProtKB:Q60547}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SYCP3 Gene COMPARTMENTS Subcellular localization image for SYCP3 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for SYCP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 22899867
genes like me logo Genes that share ontologies with SYCP3: view

Pathways & Interactions for SYCP3 Gene

genes like me logo Genes that share pathways with SYCP3: view

Pathways by source for SYCP3 Gene

3 Reactome pathways for SYCP3 Gene
1 KEGG pathway for SYCP3 Gene

Gene Ontology (GO) - Biological Process for SYCP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007141 male meiosis I NAS 15218256
genes like me logo Genes that share ontologies with SYCP3: view

No data available for SIGNOR curated interactions for SYCP3 Gene

Drugs & Compounds for SYCP3 Gene

No Compound Related Data Available

Transcripts for SYCP3 Gene

Unigene Clusters for SYCP3 Gene

Synaptonemal complex protein 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SYCP3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8
SP1: -
SP2: - -
SP3: -
SP4: - -
SP5: -

Relevant External Links for SYCP3 Gene

GeneLoc Exon Structure for
SYCP3
ECgene alternative splicing isoforms for
SYCP3

Expression for SYCP3 Gene

mRNA expression in normal human tissues for SYCP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SYCP3 Gene

This gene is overexpressed in Testis (x44.7).

Protein differential expression in normal tissues from HIPED for SYCP3 Gene

This gene is overexpressed in Testis (31.5), Fetal ovary (21.1), and Ovary (16.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SYCP3 Gene



SOURCE GeneReport for Unigene cluster for SYCP3 Gene Hs.506504

mRNA Expression by UniProt/SwissProt for SYCP3 Gene

Q8IZU3-SYCP3_HUMAN
Tissue specificity: Testis-specific.
genes like me logo Genes that share expression patterns with SYCP3: view

Protein tissue co-expression partners for SYCP3 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for SYCP3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SYCP3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SYCP3 35
  • 88.84 (n)
  • 82.11 (a)
SYCP3 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SYCP3 35
  • 88.65 (n)
  • 82.98 (a)
-- 36
  • 47 (a)
OneToMany
-- 36
  • 48 (a)
OneToMany
-- 36
  • 42 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Sycp3 35
  • 84.05 (n)
  • 72.65 (a)
Sycp3 16
1700013H16Rik 36
  • 28 (a)
OneToMany
3830403N18Rik 36
  • 34 (a)
OneToMany
Gm1140 36
  • 23 (a)
OneToMany
Gm14692 36
  • 23 (a)
OneToMany
Gm20736 36
  • 31 (a)
OneToMany
Gm20843 36
  • 31 (a)
OneToMany
Gm20874 36
  • 31 (a)
OneToMany
Gm20888 36
  • 31 (a)
OneToMany
Gm20901 36
  • 33 (a)
OneToMany
Gm20923 36
  • 31 (a)
OneToMany
Gm20937 36
  • 31 (a)
OneToMany
Gm21171 36
  • 31 (a)
OneToMany
Gm21209 36
  • 31 (a)
OneToMany
Gm21258 36
  • 31 (a)
OneToMany
Gm21518 36
  • 31 (a)
OneToMany
Gm21638 36
  • 31 (a)
OneToMany
Gm21650 36
  • 31 (a)
OneToMany
Gm773 36
  • 29 (a)
OneToMany
Sycp3 36
  • 67 (a)
OneToMany
Xlr 36
  • 33 (a)
OneToMany
Xlr3a 36
  • 28 (a)
OneToMany
Xlr3b 36
  • 26 (a)
OneToMany
Xlr3c 36
  • 26 (a)
OneToMany
Xlr4a 36
  • 24 (a)
OneToMany
Xlr4b 36
  • 24 (a)
OneToMany
Xlr4c 36
  • 25 (a)
OneToMany
Xlr5a 36
  • 23 (a)
OneToMany
Xlr5b 36
  • 24 (a)
OneToMany
Xlr5c 36
  • 20 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia SYCP3 35
  • 99.72 (n)
  • 100 (a)
SYCP3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sycp3 35
  • 83.62 (n)
  • 73.08 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 34 (a)
OneToMany
-- 36
  • 34 (a)
OneToMany
chicken
(Gallus gallus)
Aves SYCP3 35
  • 78.44 (n)
  • 77.02 (a)
SYCP3 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sycp3 35
  • 72.78 (n)
  • 66.81 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.15474 35
sycp3 35
  • 63.83 (n)
  • 55.32 (a)
sycp3 36
  • 55 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4217 36
  • 32 (a)
OneToOne
Species with no ortholog for SYCP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SYCP3 Gene

ENSEMBL:
Gene Tree for SYCP3 (if available)
TreeFam:
Gene Tree for SYCP3 (if available)

Paralogs for SYCP3 Gene

Pseudogenes.org Pseudogenes for SYCP3 Gene

genes like me logo Genes that share paralogs with SYCP3: view

No data available for Paralogs for SYCP3 Gene

Variants for SYCP3 Gene

Structural Variations from Database of Genomic Variants (DGV) for SYCP3 Gene

Variant ID Type Subtype PubMed ID
nsv832497 CNV Gain 17160897
nsv860 CNV Loss 18451855

Variation tolerance for SYCP3 Gene

Residual Variation Intolerance Score: 31.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.21; 4.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SYCP3 Gene

HapMap Linkage Disequilibrium report
SYCP3
Human Gene Mutation Database (HGMD)
SYCP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for SYCP3 Gene

Disorders for SYCP3 Gene

MalaCards: The human disease database

(5) MalaCards diseases for SYCP3 Gene - From: OMIM, ClinVar, GeneTests, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
spermatogenic failure 4
  • spermatogenesis arrest
sycp3-related pregnancy loss, susceptibility to
azoospermia
  • spermatogenic failure
mannosidosis, beta
  • beta-mannosidosis
male reproductive system disease
  • genital diseases, male
- elite association - COSMIC cancer census association via MalaCards
Search SYCP3 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

SYCP3_HUMAN
  • Spermatogenic failure 4 (SPGF4) [MIM:270960]: An infertility disorder characterized by azoospermia, a condition of having no sperm present in the ejaculate. Testicular histology shows arrest of spermatogenesis at the pachytene stage of primary spermatocytes. {ECO:0000269 PubMed:14643120}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for SYCP3

Genetic Association Database (GAD)
SYCP3
Human Genome Epidemiology (HuGE) Navigator
SYCP3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SYCP3
genes like me logo Genes that share disorders with SYCP3: view

No data available for Genatlas for SYCP3 Gene

Publications for SYCP3 Gene

  1. Azoospermia in patients heterozygous for a mutation in SYCP3. (PMID: 14643120) Miyamoto T. … Lamb D.J. (Lancet 2003) 3 4 23 48 67
  2. Ectopic expression of X-linked lymphocyte-regulated protein pM1 renders tumor cells resistant to antitumor immunity. (PMID: 20395201) Kang T.H. … Kim T.W. (Cancer Res. 2010) 3 23
  3. Mutations of the SYCP3 gene in women with recurrent pregnancy loss. (PMID: 19110213) Bolor H. … Kurahashi H. (Am. J. Hum. Genet. 2009) 3 23
  4. Mammalian neo-oogenesis and expression of meiosis-specific protein SCP3 in adult human and monkey ovaries. (PMID: 18256545) Bukovsky A. … Dominguez R. (Cell Cycle 2008) 3 23
  5. Testicular expression of synaptonemal complex protein 3 (SYCP3) messenger ribonucleic acid in 110 patients with nonobstructive azoospermia. (PMID: 16824523) Aarabi M. … Akhondi M.M. (Fertil. Steril. 2006) 3 23

Products for SYCP3 Gene

Sources for SYCP3 Gene

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