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Aliases for SYCP3 Gene

Aliases for SYCP3 Gene

  • Synaptonemal Complex Protein 3 2 3
  • SCP3 3 4 6
  • SPGF4 3 6
  • COR1 3 6
  • SCP-3 4

External Ids for SYCP3 Gene

Summaries for SYCP3 Gene

Entrez Gene Summary for SYCP3 Gene

  • This gene encodes an essential structural component of the synaptonemal complex. This complex is involved in synapsis, recombination and segregation of meiotic chromosomes. Mutations in this gene are associated with azoospermia in males and susceptibility to pregnancy loss in females. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, May 2010]

GeneCards Summary for SYCP3 Gene

SYCP3 (Synaptonemal Complex Protein 3) is a Protein Coding gene. Diseases associated with SYCP3 include spermatogenic failure 4 and sycp3-related pregnancy loss, susceptibility to. Among its related pathways are Cell Cycle, Mitotic and Meiosis.

UniProtKB/Swiss-Prot for SYCP3 Gene

  • Component of the transverse filaments of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Has an essential meiotic function in spermatogenesis. May be important for testis development. Required for efficient phosphorylation of HORMAD1 and HORMAD2 (By similarity).

Gene Wiki entry for SYCP3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYCP3 Gene

Genomics for SYCP3 Gene

Genomic Location for SYCP3 Gene

Start:
101,728,648 bp from pter
End:
101,739,689 bp from pter
Size:
11,042 bases
Orientation:
Minus strand

Genomic View for SYCP3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SYCP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYCP3 Gene

Regulatory Elements for SYCP3 Gene

Proteins for SYCP3 Gene

  • Protein details for SYCP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZU3-SYCP3_HUMAN
    Recommended name:
    Synaptonemal complex protein 3
    Protein Accession:
    Q8IZU3
    Secondary Accessions:

    Protein attributes for SYCP3 Gene

    Size:
    236 amino acids
    Molecular mass:
    27729 Da
    Quaternary structure:
    • Interacts with SYCP2.

    Three dimensional structures from OCA and Proteopedia for SYCP3 Gene

neXtProt entry for SYCP3 Gene

Proteomics data for SYCP3 Gene at MOPED

Post-translational modifications for SYCP3 Gene

Other Protein References for SYCP3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SYCP3 Gene

Domains for SYCP3 Gene

Protein Domains for SYCP3 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

SYCP3_HUMAN
Family:
  • Belongs to the XLR/SYCP3 family.:
    • Q8IZU3
genes like me logo Genes that share domains with SYCP3: view

No data available for Gene Families for SYCP3 Gene

Function for SYCP3 Gene

Molecular function for SYCP3 Gene

UniProtKB/Swiss-Prot Function: Component of the transverse filaments of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Has an essential meiotic function in spermatogenesis. May be important for testis development. Required for efficient phosphorylation of HORMAD1 and HORMAD2 (By similarity).

Gene Ontology (GO) - Molecular Function for SYCP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with SYCP3: view

Phenotypes for SYCP3 Gene

genes like me logo Genes that share phenotypes with SYCP3: view

Animal Models for SYCP3 Gene

MGI Knock Outs for SYCP3:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for SYCP3 Gene

Localization for SYCP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYCP3 Gene

Nucleus. Chromosome. Note=In tripartite segments of synaptonemal complexes, irrespective of whether these are synapsed or unsynapsed. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SYCP3 Gene COMPARTMENTS Subcellular localization image for SYCP3 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for SYCP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 22899867
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with SYCP3: view

Pathways for SYCP3 Gene

genes like me logo Genes that share pathways with SYCP3: view

Pathways by source for SYCP3 Gene

4 Reactome pathways for SYCP3 Gene

Gene Ontology (GO) - Biological Process for SYCP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007141 male meiosis I NAS 15218256
GO:0035093 spermatogenesis, exchange of chromosomal proteins IMP 14643120
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with SYCP3: view

Transcripts for SYCP3 Gene

Unigene Clusters for SYCP3 Gene

Synaptonemal complex protein 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SYCP3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8
SP1: -
SP2: - -
SP3: -
SP4: - -
SP5: -

Relevant External Links for SYCP3 Gene

GeneLoc Exon Structure for
SYCP3
ECgene alternative splicing isoforms for
SYCP3

Expression for SYCP3 Gene

mRNA expression in normal human tissues for SYCP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SYCP3 Gene

This gene is overexpressed in Testis (44.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SYCP3 Gene

SOURCE GeneReport for Unigene cluster for SYCP3 Gene Hs.506504

mRNA Expression by UniProt/SwissProt for SYCP3 Gene

Q8IZU3-SYCP3_HUMAN
Tissue specificity: Testis-specific.
genes like me logo Genes that share expressions with SYCP3: view

Orthologs for SYCP3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SYCP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SYCP3 36
  • 99.72 (n)
  • 100 (a)
SYCP3 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SYCP3 36
  • 88.84 (n)
  • 82.11 (a)
SYCP3 37
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 37
  • 47 (a)
OneToMany
-- 37
  • 48 (a)
OneToMany
-- 37
  • 42 (a)
OneToMany
SYCP3 36
  • 88.65 (n)
  • 82.98 (a)
mouse
(Mus musculus)
Mammalia 1700013H16Rik 37
  • 28 (a)
OneToMany
3830403N18Rik 37
  • 34 (a)
OneToMany
Gm1140 37
  • 23 (a)
OneToMany
Gm14692 37
  • 23 (a)
OneToMany
Gm20736 37
  • 31 (a)
OneToMany
Gm20843 37
  • 31 (a)
OneToMany
Gm20874 37
  • 31 (a)
OneToMany
Gm20888 37
  • 31 (a)
OneToMany
Gm20901 37
  • 33 (a)
OneToMany
Gm20923 37
  • 31 (a)
OneToMany
Gm20937 37
  • 31 (a)
OneToMany
Gm21171 37
  • 31 (a)
OneToMany
Gm21209 37
  • 31 (a)
OneToMany
Gm21258 37
  • 31 (a)
OneToMany
Gm21518 37
  • 31 (a)
OneToMany
Gm21638 37
  • 31 (a)
OneToMany
Gm21650 37
  • 31 (a)
OneToMany
Gm773 37
  • 29 (a)
OneToMany
Sycp3 36
  • 84.05 (n)
  • 72.65 (a)
Sycp3 16
Sycp3 37
  • 67 (a)
OneToMany
Xlr 37
  • 33 (a)
OneToMany
Xlr3a 37
  • 28 (a)
OneToMany
Xlr3b 37
  • 26 (a)
OneToMany
Xlr3c 37
  • 26 (a)
OneToMany
Xlr4a 37
  • 24 (a)
OneToMany
Xlr4b 37
  • 24 (a)
OneToMany
Xlr4c 37
  • 25 (a)
OneToMany
Xlr5a 37
  • 23 (a)
OneToMany
Xlr5b 37
  • 24 (a)
OneToMany
Xlr5c 37
  • 20 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 34 (a)
OneToMany
-- 37
  • 34 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Sycp3 36
  • 83.62 (n)
  • 73.08 (a)
chicken
(Gallus gallus)
Aves SYCP3 36
  • 78.44 (n)
  • 77.02 (a)
SYCP3 37
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sycp3 36
  • 72.78 (n)
  • 66.81 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.15474 36
sycp3 36
  • 63.83 (n)
  • 55.32 (a)
sycp3 37
  • 55 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4217 37
  • 32 (a)
OneToOne
Species with no ortholog for SYCP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SYCP3 Gene

ENSEMBL:
Gene Tree for SYCP3 (if available)
TreeFam:
Gene Tree for SYCP3 (if available)

Paralogs for SYCP3 Gene

Pseudogenes.org Pseudogenes for SYCP3 Gene

genes like me logo Genes that share paralogs with SYCP3: view

No data available for Paralogs for SYCP3 Gene

Variants for SYCP3 Gene

Sequence variations from dbSNP and Humsavar for SYCP3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1065472 -- 101,736,045(-) TGGTC(C/T)TTGTC intron-variant
rs2041151 -- 101,735,871(+) tatat(A/T)ttttt intron-variant
rs2288379 -- 101,730,141(-) CCAAT(A/C)TATCC intron-variant
rs3751248 -- 101,737,786(+) CCCAA(A/C)ATGAG intron-variant
rs5800484 -- 101,735,814(+) AAAAA(-/TAGT)TAAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SYCP3 Gene

Variant ID Type Subtype PubMed ID
nsv832497 CNV Gain 17160897
nsv860 CNV Loss 18451855

Relevant External Links for SYCP3 Gene

HapMap Linkage Disequilibrium report
SYCP3
Human Gene Mutation Database (HGMD)
SYCP3

Disorders for SYCP3 Gene

(1) OMIM Diseases for SYCP3 Gene (604759)

UniProtKB/Swiss-Prot

SYCP3_HUMAN
  • Spermatogenic failure 4 (SPGF4) [MIM:270960]: An infertility disorder characterized by azoospermia, a condition of having no sperm present in the ejaculate. Testicular histology shows arrest of spermatogenesis at the pachytene stage of primary spermatocytes. {ECO:0000269 PubMed:14643120}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(2) University of Copenhagen DISEASES for SYCP3 Gene

(3) Novoseek inferred disease relationships for SYCP3 Gene

Disease -log(P) Hits PubMed IDs
azoospermia 80.4 8
ataxia telangiectasia 47.9 1
infertility 40.1 1

Relevant External Links for SYCP3

Genetic Association Database (GAD)
SYCP3
Human Genome Epidemiology (HuGE) Navigator
SYCP3
genes like me logo Genes that share disorders with SYCP3: view

Publications for SYCP3 Gene

  1. Azoospermia in patients heterozygous for a mutation in SYCP3. (PMID: 14643120) Miyamoto T. … Lamb D.J. (Lancet 2003) 3 4 23 49
  2. Mutations of the SYCP3 gene in women with recurrent pregnancy loss. (PMID: 19110213) Bolor H. … Kurahashi H. (Am. J. Hum. Genet. 2009) 3 23 49
  3. A new gene family (FAM9) of low-copy repeats in Xp22.3 expressed exclusively in testis: implications for recombinations in this region. (PMID: 12213195) Martinez-Garay I. … Kutsche K. (Genomics 2002) 2 3 4
  4. Mammalian neo-oogenesis and expression of meiosis-specific protein SCP3 in adult human and monkey ovaries. (PMID: 18256545) Bukovsky A. … Dominguez R. (Cell Cycle 2008) 3 23
  5. Ectopic expression of X-linked lymphocyte-regulated protein pM1 renders tumor cells resistant to antitumor immunity. (PMID: 20395201) Kang T.H. … Kim T.W. (Cancer Res. 2010) 3 23

Products for SYCP3 Gene

Sources for SYCP3 Gene

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