Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SYCP3 Gene

protein-coding   GIFtS: 59
GCID: GC12M102105

Synaptonemal Complex Protein 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
Synaptonemal Complex Protein 31 2
SCP32 3 5
COR12 5
SPGF42 5
SCP-33

External Ids:    HGNC: 181301   Entrez Gene: 505112   Ensembl: ENSG000001393517   OMIM: 6047595   UniProtKB: Q8IZU33   
ORGUL members:         

Export aliases for SYCP3 gene to outside databases

Previous GC identifers: GC12U990147 GC12M100624 GC12M099182


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for SYCP3 Gene:
This gene encodes an essential structural component of the synaptonemal complex. This complex is involved in
synapsis, recombination and segregation of meiotic chromosomes. Mutations in this gene are associated with
azoospermia in males and susceptibility to pregnancy loss in females. Alternate splicing results in multiple
transcript variants that encode the same protein. (provided by RefSeq, May 2010)

GeneCards Summary for SYCP3 Gene:
SYCP3 (synaptonemal complex protein 3) is a protein-coding gene. Diseases associated with SYCP3 include pregnancy loss, and azoospermia due to perturbations of meiosis.

UniProtKB/Swiss-Prot: SYCP3_HUMAN, Q8IZU3
Function: Component of the transverse filaments of synaptonemal complexes (SCS), formed between homologous
chromosomes during meiotic prophase. Has an essential meiotic function in spermatogenesis. May be important for
testis development. Required for efficient phosphorylation of HORMAD1 and HORMAD2 (By similarity)

Gene Wiki entry for SYCP3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000012.12  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SYCP3 gene promoter:
         AML1a   Nkx2-2   FOXD3   Nkx2-5   STAT5A   NF-YB   Ik-2   IRF-7A   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSYCP3 promoter sequence
   Search Chromatin IP Primers for SYCP3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SYCP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q   Ensembl cytogenetic band:  12q23.2   HGNC cytogenetic band: 12q23.2

SYCP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SYCP3 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M102105:  view genomic region     (about GC identifiers)

Start:
102,122,426 bp from pter      End:
102,133,250 bp from pter
Size:
10,825 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: SYCP3_HUMAN, Q8IZU3 (See protein sequence)
Recommended Name: Synaptonemal complex protein 3  
Size: 236 amino acids; 27729 Da
Subunit: Interacts with SYCP2 (By similarity)

Explore the universe of human proteins at neXtProt for SYCP3: NX_Q8IZU3

Explore proteomics data for SYCP3 at MOPED

Post-translational modifications: 

  • Phosphorylated (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SYCP3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001171419.1  NP_001171420.1  NP_710161.1  

    ENSEMBL proteins: 
     ENSP00000266743   ENSP00000376658   ENSP00000376655  
    Reactome Protein details: Q8IZU3

    SYCP3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for SYCP3
    OriGene Protein Over-expression Lysate for SYCP3
    OriGene MassSpec for SYCP3
    OriGene Custom Protein Services for SYCP3
    GenScript Custom Purified and Recombinant Proteins Services for SYCP3
    Novus Biologicals SYCP3 Proteins
    Novus Biologicals SYCP3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SYCP3

    SYCP3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for SYCP3 (SCP3/SYCP3)
    OriGene Antibodies for SYCP3
    OriGene Custom Antibody Services for SYCP3
    Novus Biologicals SYCP3 Antibodies
    Abcam antibodies for SYCP3
    Cloud-Clone Corp. Antibodies for SYCP3
    ThermoFisher Antibodies for SYCP3
    LSBio Antibodies in human, mouse, rat for SYCP3

    SYCP3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SYCP3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SYCP3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SYCP3
    Cloud-Clone Corp. CLIAs for SYCP3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR006888 Cor1/Xlr/Xmr

    Graphical View of Domain Structure for InterPro Entry Q8IZU3

    ProtoNet protein and cluster: Q8IZU3

    1 Blocks protein domain: IPB006888 Cor1/Xlr/Xmr conserved region

    UniProtKB/Swiss-Prot: SYCP3_HUMAN, Q8IZU3
    Similarity: Belongs to the XLR/SYCP3 family


    SYCP3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SYCP3_HUMAN, Q8IZU3
    Function: Component of the transverse filaments of synaptonemal complexes (SCS), formed between homologous
    chromosomes during meiotic prophase. Has an essential meiotic function in spermatogenesis. May be important for
    testis development. Required for efficient phosphorylation of HORMAD1 and HORMAD2 (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
         
    SYCP3 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Sycp3):
     endocrine/exocrine gland  reproductive system 

    SYCP3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for SYCP3: Sycp3tm1Hoog Sycp3tm1(KOMP)Vlcg

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SYCP3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SYCP3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SYCP3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SYCP3

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat SYCP3 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate SYCP3
    SwitchGear 3'UTR luciferase reporter plasmidSYCP3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SYCP3
    Predesigned siRNA for gene silencing in human, mouse, rat SYCP3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SYCP3

    Clone
    Products:
         
    OriGene clones in human, mouse for SYCP3 (see all 14)
    OriGene ORF clones in mouse, rat for SYCP3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): SYCP3 (NM_153694)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SYCP3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYCP3

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SYCP3
    Browse ESI BIO Cell Lines and PureStem Progenitors for SYCP3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYCP3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    SYCP3_HUMAN, Q8IZU3: Nucleus (By similarity). Chromosome (By similarity). Note=In tripartite segments of
    synaptonemal complexes, irrespective of whether these are synapsed or unsynapsed (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005694chromosome IEA--

    SYCP3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for SYCP3 About    
    See pathways by source

    SuperPathContained pathways About
    1Packaging Of Telomere Ends
    Meiotic Synapsis0.66
    Chromosome Maintenance0.62
    2Cell Cycle, Mitotic
    Cell Cycle0.90
    3Meiosis (REACTOME)
    Meiosis0.74
    4Meiosis (EMD)
    Meiosis

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for SYCP3
        Meiotic synapsis



    SYCP3 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including SYCP3: 
              Embryonic Stem Cells in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for SYCP3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SYCP3 (Q8IZU32, 3 ENSP000002667434) via UniProtKB, MINT, STRING, and/or I2D (see all 30)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BRCA2P515872, ENSP000003694974MINT-8303514 MINT-8303444 STRING: ENSP00000369497
    KAT8Q9H7Z63, ENSP000004060374I2D: score=1 STRING: ENSP00000406037
    PABPC1P119403, ENSP000003130074I2D: score=1 STRING: ENSP00000313007
    SMC1AQ146833, ENSP000003234214I2D: score=1 STRING: ENSP00000323421
    SMC3Q9UQE73, ENSP000003547204I2D: score=1 STRING: ENSP00000354720
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007141male meiosis I NAS15218256
    GO:0035093spermatogenesis, exchange of chromosomal proteins IMP14643120
    GO:0051301cell division ----

    SYCP3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SYCP3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for SYCP3 gene (3 alternative transcripts): 
    NM_001177948.1  NM_001177949.1  NM_153694.4  

    Unigene Cluster for SYCP3:

    Synaptonemal complex protein 3
    Hs.506504  [show with all ESTs]
    Unigene Representative Sequence: BC062662
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000478238 ENST00000266743 ENST00000478139(uc001tis.3) ENST00000392927(uc001tir.3 uc001tiq.3)
    ENST00000392924
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SYCP3 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate SYCP3
    SwitchGear 3'UTR luciferase reporter plasmidSYCP3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SYCP3
    Predesigned siRNA for gene silencing in human, mouse, rat SYCP3
    Clone
    Products:
         
    OriGene clones in human, mouse for SYCP3 (see all 14)
    OriGene ORF clones in mouse, rat for SYCP3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): SYCP3 (NM_153694)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SYCP3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYCP3
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for SYCP3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SYCP3
      QuantiTect SYBR Green Assays in human, mouse, rat SYCP3
      QuantiFast Probe-based Assays in human, mouse, rat SYCP3

    Additional mRNA sequence: 

    AF492003.1 AF517774.1 BC062662.1 

    10 DOTS entries:

    DT.95258155  DT.440957  DT.121178796  DT.40240243  DT.40264019  DT.456021  DT.91716996  DT.100818423 
    DT.121178791  DT.91823852 

    Selected AceView cDNA sequences (see all 32):

    AF517774 AF492003 BC062662 BU852431 AW972555 AK125930 AI075991 AI214984 
    BG207820 AA971665 AL045184 NM_153694 BU165769 BU568620 BG215085 BQ428625 
    BG202454 AI285929 BU568927 BG212523 BG201028 BG189124 BG202574 BG191294 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for SYCP3    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8
    SP1:                                -                                                   
    SP2:                    -           -                                                   
    SP3:                                -                                                   
    SP4:                    -           -                                                   
    SP5:                    -                                                               


    ECgene alternative splicing isoforms for SYCP3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    SYCP3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTATTCTGAT
    SYCP3 Expression
    About this image


    SYCP3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Gonad (Reproductive System)    fully expand to see all 5 entries
             Primordial Germ Cells Primitive Gonad
             Human oogonial stem cells
     
     Ovary (Reproductive System)    fully expand to see all 4 entries
             Ovarian Somatic Cells Ovigerous Cord
             Ovarian tissue-dissociated cells (human)
             Oocytes
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             XY Germ Cells Testis Cord
             Long-time differentiated EBs
             testis ; cells in seminiferous ducts   
     
     Germ Cells (Reproductive System)
             Human oogonial stem cells
     
     Inner Cell Mass (Early Embryonic Tissues)
             ES-J1
    SYCP3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SYCP3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.506504

    UniProtKB/Swiss-Prot: SYCP3_HUMAN, Q8IZU3
    Tissue specificity: Testis-specific

        Pathway & Disease-focused RT2 Profiler PCR Array including SYCP3: 
              Embryonic Stem Cells in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for SYCP3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SYCP3
    QuantiTect SYBR Green Assays in human, mouse, rat SYCP3
    QuantiFast Probe-based Assays in human, mouse, rat SYCP3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYCP3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for SYCP3 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sycp31 , 5 synaptonemal complex protein 31, 5 84.05(n)1
    72.65(a)1
      10 (43.94 cM)5
    209621  NM_011517.21  NP_035647.21 
     884595695 
    chicken
    (Gallus gallus)
    Aves SYCP31 synaptonemal complex protein 3 78.44(n)
    77.02(a)
      418097  XM_004937837.1  XP_004937894.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia sycp31 synaptonemal complex protein 3 72.78(n)
    66.81(a)
      779673  NM_001078758.1  NP_001072226.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.154742 Transcribed sequence with weak similarity to protein more 77.93(n)    BQ074134.1 


    ENSEMBL Gene Tree for SYCP3 (if available)
    TreeFam Gene Tree for SYCP3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for SYCP3 gene

    SYCP3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SYCP3
    PGOHUM00000244626


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for SYCP3 (see all 277)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1154847571,2
    C,F--101962421(+) ATAAAC/TGCAGA 3 -- ds50012Minor allele frequency- T:0.06WA NA 238
    rs1425315931,2
    --101962453(+) GAAATC/TAGGTA 3 -- ds50010--------
    rs1437275361,2
    C--101962510(+) GTGAC-/ATTATGTC 3 -- ds50010--------
    rs772881921,2
    C,F--101962535(+) ACATAT/GTCACA 3 -- ds50012Minor allele frequency- G:0.20WA 120
    rs1505403771,2
    --101962563(+) TGTTAG/TTTATA 3 -- ds50010--------
    rs1813436771,2
    --101962732(+) TTTTTA/CCTTAA 3 -- ds50010--------
    rs1398461631,2
    C--101962736(+) TCCTT-/AAAG  
            
    AACAT
    3 -- ds50010--------
    rs177238331,2
    C,F--101962879(+) GAAAGC/TTTAAT 3 -- ut315Minor allele frequency- T:0.01NA 146
    rs1150134751,2
    C,F--101962901(+) AGGAAT/CAGTTG 3 -- ut311Minor allele frequency- C:0.02WA 118
    rs1858206311,2
    C--101963033(+) CTAACA/GTTATA 3 -- ut310--------

    HapMap Linkage Disequilibrium report for SYCP3 (102122426 - 102133250 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SYCP3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv860CNV Loss18451855
    nsv832497CNV Gain17160897

    Human Gene Mutation Database (HGMD): SYCP3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SYCP3
    DNA2.0 Custom Variant and Variant Library Synthesis for SYCP3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 604759   
    OMIM disorders: 270960  
    UniProtKB/Swiss-Prot: SYCP3_HUMAN, Q8IZU3
  • Spermatogenic failure 4 (SPGF4) [MIM:270960]: An infertility disorder characterized by azoospermia, a
    condition of having no sperm present in the ejaculate. Testicular histology shows arrest of spermatogenesis at
    the pachytene stage of primary spermatocytes. Note=The disease is caused by mutations affecting the gene
    represented in this entry

  • 15 diseases for SYCP3:    
    About MalaCards
    pregnancy loss    azoospermia due to perturbations of meiosis    sycp3-related pregnancy loss, susceptibility to    spermatogenic failure 4
    reflex sympathetic dystrophy    azoospermia    gemistocytic astrocytoma    beta-mannosidosis
    ataxia telangiectasia    infertility    astrocytoma    ataxia
    multiple myeloma    myeloma    lung cancer

    2 diseases from the University of Copenhagen DISEASES database for SYCP3:
    Azoospermia     Gemistocytic astrocytoma

    SYCP3 for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for SYCP3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    azoospermia 80.4 11 14643120 (3), 16824523 (2), 16520322 (1), 16227348 (1) (see all 5)
    ataxia telangiectasia 47.9 2 15218256 (1)
    infertility 40.1 1 16520322 (1)

    Genetic Association Database (GAD): SYCP3
    Human Genome Epidemiology (HuGE) Navigator: SYCP3 (5 documents)

    Export disorders for SYCP3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for SYCP3 gene, integrated from 10 sources (see all 44):
    (articles sorted by number of sources associating them with SYCP3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Azoospermia in patients heterozygous for a mutation in SYCP3. (PubMed id 14643120)1, 2, 4, 9 Miyamoto T.... Lamb D.J. (Lancet 2003)
    2. A new gene family (FAM9) of low-copy repeats in Xp22.3 expressed exclusively in testis: implications for recombinations in this region. (PubMed id 12213195)1, 2, 3 Martinez-Garay I....Kutsche K. (Genomics 2002)
    3. Mutations of the SYCP3 gene in women with recurrent pregnancy loss. (PubMed id 19110213)1, 4, 9 Bolor H....Kurahashi H. (Am. J. Hum. Genet. 2009)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Comparative genome sequence analysis of the Bpa/Str region in mouse and man. (PubMed id 10854409)1, 3 Mallon A.-M....Brown S.D.M. (Genome Res. 2000)
    6. Testicular expression of synaptonemal complex protein 3 (SYCP3) messenger ribonucleic acid in 110 patients with nonobstructive azoospermia. (PubMed id 16824523)1, 9 Aarabi M....Akhondi M.M. (Fertil. Steril. 2006)
    7. Ectopic expression of X-linked lymphocyte-regulated protein pM1 renders tumor cells resistant to antitumor immunity. (PubMed id 20395201)1, 9 Kang T.H....Kim T.W. (Cancer Res. 2010)
    8. Mammalian neo-oogenesis and expression of meiosis-specific protein SCP3 in adult human and monkey ovaries. (PubMed id 18256545)1, 9 Bukovsky A....Dominguez R. (Cell Cycle 2008)
    9. Kinetics of meiosis in azoospermic males: a joint histological and cytological approach. (PubMed id 15218256)1, 9 de Boer P....te Velde E.R. (Cytogenet. Genome Res. 2004)
    10. Synaptonemal complex protein 3 as a novel prognostic marker in early stage non-small cell lung cancer. (PubMed id 23069255)1 Chung J.Y....Hewitt S.M. (Hum. Pathol. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 50511 HGNC: 18130 AceView: SYCP3 Ensembl:ENSG00000139351 euGenes: HUgn50511
    ECgene: SYCP3 H-InvDB: SYCP3

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SYCP3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SYCP3 gene:
    Search GeneIP for patents involving SYCP3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for SYCP3 (SCP3/SYCP3)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for SYCP3   OriGene RNAi products in human, mouse, rat for SYCP3  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for SYCP3  
     OriGene MassSpec something-or-other for SYCP3   OriGene clones in human, mouse for SYCP3  
     OriGene qSTAR qPCR primer pairs in human, mouse for SYCP3   OriGene Purified Protein for SYCP3  
     OriGene ORF clones in mouse, rat for SYCP3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SYCP3   OriGene Custom Protein Services for SYCP3  

     
     
     Block miRNA regulation of human, mouse, rat SYCP3 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SYCP3
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SYCP3 Predesigned siRNA for gene silencing in human, mouse, rat SYCP3
     QuantiFast Probe-based Assays in human, mouse, rat SYCP3 QuantiTect SYBR Green Assays in human, mouse, rat SYCP3
     PCR Arrays including human, mouse, rat SYCP3 Search Chromatin IP Primers for SYCP3
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SYCP3  Search GeneGlobe Interaction Network for SYCP3
     Regulatory tfbs in SYCP3 promoter
     GenScript Custom Purified and Recombinant Proteins Services for SYCP3 GenScript cDNA clones with any tag delivered in your preferred vector for SYCP3
     GenScript Custom Assay Services for SYCP3 GenScript Custom overexpressing Cell Line Services for SYCP3
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for SYCP3
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SYCP3 antibodies
     SYCP3 proteins
     SYCP3 lysates
     Antibodies for SYCP3
     See all of Abcam's Antibodies, Kits and Proteins for SYCP3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for SYCP3
     Antibodies for SYCP3
     ELISAs for SYCP3
     CLIAs for SYCP3



     Browse ESI BIO Cell Lines and PureStem Progenitors for SYCP3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYCP3
     SwitchGear 3'UTR luciferase reporter plasmids for SYCP3
     SwitchGear Promoter luciferase reporter plasmids for SYCP3
     ThermoFisher Antibodies for SYCP3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYCP3
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SYCP3
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SYCP3
     LSBio Antibodies in human, mouse, rat for SYCP3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SYCP3 gene at Home site.
    Version: 3.12.162 20 Aug 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4