SYCP2L Gene
protein-coding GIFtS: 39
GCID: GC06P010762
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synaptonemal complex protein 2-like(Previous name: chromosome 6 open reading frame 177 )
(Previous symbol: C6orf177)
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Aliases
for SYCP2L gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Synaptonemal Complex Protein 2-Like1 2 | | 145 KDa Nucleolar Protein Homolog2 3 | | C6orf1771 2 3 | | SCP-2-Like1 | | NO1451 2 3 | | Chromosome 6 Open Reading Frame 1771 | | DJ62D2.11 | | HsNO1451 |
Export aliases for SYCP2L gene to outside databasesPrevious GC identifers: GC06P010997 GC06P010887 |
Summaries
for SYCP2L gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for SYCP2L gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007592.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SYCP2L gene promoter:
p53 Bach2 SREBP-1c Pax-2 Pax-2a GATA-1 SREBP-1b SREBP-1a POU2F1 POU2F1a
Other transcription factors
Search SABiosciences Chromatin IP Primers for SYCP2L
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SYCP2L |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p24.2 Ensembl cytogenetic band: 6p24.2 HGNC cytogenetic band: 6p24.2SYCP2L Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P010762: view genomic region
(about GC identifiers)
Start:
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10,748,027 bp from pter |
End:
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10,979,553 bp from pter |
Size:
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231,527 bases |
Orientation:
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plus strand |
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Proteins
for SYCP2L gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SYC2L_HUMAN, Q5T4T6 (See
protein sequence)Recommended Name: Synaptonemal complex protein 2-like Size: 812 amino acids; 93599 Da
Subcellular location: Nucleus. Note=Detected in nuclear granules and sizable aggregates
Sequence caution: Sequence=CAI16226.1; Type=Erroneous gene model prediction; Sequence=CAI22075.1; Type=Erroneous genemodel prediction;
Secondary accessions: A6NDS5 Q08GK5 Q6ZRM2 Q96EJ2Alternative splicing: 2 isoforms: Q5T4T6-1 Q5T4T6-2 Explore the universe of human proteins at neXtProt for SYCP2L: NX_Q5T4T6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5T4T6
SYCP2L Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001035364.2
ENSEMBL proteins: ENSP00000283141 ENSP00000340320 ENSP00000417870 ENSP00000440676
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
SYCP2L for ontologies About GeneDecksing
SYCP2L Antibody Products:
Assay Products for SYCP2L: |
Protein
Domains /
Families
for SYCP2L gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SYCP2L for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q5T4T6ProtoNet protein and cluster: Q5T4T6 UniProtKB/Swiss-Prot: SYC2L_HUMAN, Q5T4T6Similarity: Belongs to the SYCP2 family |
Function
for SYCP2L gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SYCP2L
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SYCP2L
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: SYCP2L (NM_001040274) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYCP2L |
1 GenomeRNAi human phenotype for SYCP2L:
|
Pathways & Interactions
for SYCP2L gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SYCP2L
|
Drugs & Compounds
for SYCP2L gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SYCP2L
Search CenterWatch for drugs/clinical trials and news about SYCP2L / SYC2L
|
Transcripts
for SYCP2L gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SYCP2L gene (2 alternative transcripts): NM_194299.1 NM_001040274.2 Unigene Cluster for SYCP2L: Synaptonemal complex protein 2-like Hs.729128 [show with all ESTs]Unigene Representative Sequence: NM_0010402747 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000283141(uc003mzo.3 uc011din.1 uc010jow.3) ENST00000341041
ENST00000487561 ENST00000474197 ENST00000465872 ENST00000488191 ENST00000543878(uc011dim.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SYCP2L
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SYCP2L
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SYCP2L (NM_001040274) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SYCP2L | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SYCP2L |
Additional cDNA sequence: AM293674.1 BC012225.1 5 DOTS entries: DT.451722 DT.40118684 DT.428416 DT.101978998 DT.121397398 22 AceView cDNA sequences: AW183165 AA782841 BX281631 BX095003 BM750187 CD724012 AA442215 AK128130 BC012225 AW663048 AI027433 BF590345 AA115860 NM_194299 BE541431 AW674916 AA115861 AA854950 D78862 D78902 C17789 H75288
GeneLoc Exon Structure
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Expression
for SYCP2L gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SYCP2L expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGAAAGACCA
About this image
See SYCP2L Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SYCP2L
SOURCE GeneReport for Unigene cluster: Hs.729128
UniProtKB/Swiss-Prot: SYC2L_HUMAN, Q5T4T6Tissue specificity: Expressed in the ovary (at protein level)
SABiosciences Custom PCR Arrays for SYCP2L
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SYCP2L
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SYCP2L | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SYCP2L | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SYCP2L | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYCP2L |
Orthologs
for SYCP2L gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for SYCP2L gene from 4/12 species (see all 12) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
SYCP2L1 |
synaptonemal complex protein 2-like |
53.33(n)
43.79(a) |
|
771534 XM_001234802.2 XP_001234803.2 |
lizard
(Anolis carolinensis) |
Reptilia |
SYCP2L6 |
-- |
13(a) |
possible ortholog |
4(147990126-148029472) |
African clawed frog
(Xenopus laevis) |
Amphibia |
NO1452 |
NO145 protein |
69.91(n) |
|
AJ249963.2 |
zebrafish
(Danio rerio) |
Actinopterygii |
LOC1001499101 |
similar to synaptonemal complex protein 2-like |
47.4(n)
33.19(a) |
|
100149910 XM_001923161.2 XP_001923196.2 |
ENSEMBL Gene Tree for SYCP2L (if available)
TreeFam Gene Tree for SYCP2L (if available) |
Paralogs
for SYCP2L gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SYCP2L gene
- SYCP22
1 SIMAP similar gene for SYCP2L using alignment to 3 protein entries: SYC2L_HUMAN (see all proteins):SYCP2
SYCP2L for paralogs About GeneDecksing
|
Genomic Variants
for SYCP2L gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SYCP2L (10748027 - 10979553 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for SYCP2L
1 CNV: 6478 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SYCP2L |
|
Disorders
/ Diseases
for SYCP2L gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 SYCP2L for disorders About MalaCards
SYCP2L for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: SYCP2L (1 document)
Export disorders for SYCP2L gene to outside databases
|
Publications
for SYCP2L gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SYCP2L gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with SYCP2L) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. (PubMed id 22267201)1 Stolk L....Lunetta K.L. (2012)
- Genetic loci associated with plasma phospholipid n-3 f atty acids: a meta-analysis of genome-wide association studies from the CHARGE C onsortium. (PubMed id 21829377)1 Lemaitre R.N....Steffen L.M. (2011)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Genome-wide association studies identify loci associa ted with age at menarche and age at natural menopause. (PubMed id 19448621)1 He C....Chasman D.I. (2009)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- Regulatory mechanisms governing the oocyte-specific synthesis of the karyoskeletal protein NO145. (PubMed id 17374641)2 Voltmer-Irsch S.... Schmidt-Zachmann M.S. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)2 Mungall A.J.... Beck S. (2003)
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External Searches for SYCP2L gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing SYCP2L gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SYCP2L gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SYCP2L gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SYCP2L | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for SYCP2L gene:
Search GeneIP for patents involving SYCP2L
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SYCP2L gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SYCP2L | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SYCP2L | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SYCP2L | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SYCP2L | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SYCP2L | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SYCP2L |
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| | | | Search Tocris compounds for SYCP2L |
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 | | | SYCP2L Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYCP2L |
|  |  |  | | | | Search ThermoFisher Antibodies for SYCP2L |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SYCP2L |
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