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Aliases for SYCP2L Gene

Aliases for SYCP2L Gene

  • Synaptonemal Complex Protein 2 Like 2 3 5
  • 145 KDa Nucleolar Protein Homolog 3 4
  • SCP-2-Like 3 4
  • C6orf177 3 4
  • NO145 3 4
  • Chromosome 6 Open Reading Frame 177 2
  • Synaptonemal Complex Protein 2-Like 2
  • DJ62D2.1 3
  • HsNO145 4

External Ids for SYCP2L Gene

Previous HGNC Symbols for SYCP2L Gene

  • C6orf177

Previous GeneCards Identifiers for SYCP2L Gene

  • GC06P010997
  • GC06P010762

Summaries for SYCP2L Gene

GeneCards Summary for SYCP2L Gene

SYCP2L (Synaptonemal Complex Protein 2 Like) is a Protein Coding gene. An important paralog of this gene is SYCP2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYCP2L Gene

Genomics for SYCP2L Gene

Regulatory Elements for SYCP2L Gene

Promoters for SYCP2L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SYCP2L on UCSC Golden Path with GeneCards custom track

Genomic Location for SYCP2L Gene

Chromosome:
6
Start:
10,886,831 bp from pter
End:
10,979,320 bp from pter
Size:
92,490 bases
Orientation:
Plus strand

Genomic View for SYCP2L Gene

Genes around SYCP2L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SYCP2L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SYCP2L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYCP2L Gene

Proteins for SYCP2L Gene

  • Protein details for SYCP2L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T4T6-SYC2L_HUMAN
    Recommended name:
    Synaptonemal complex protein 2-like
    Protein Accession:
    Q5T4T6
    Secondary Accessions:
    • A6NDS5
    • Q08GK5
    • Q6ZRM2
    • Q96EJ2

    Protein attributes for SYCP2L Gene

    Size:
    812 amino acids
    Molecular mass:
    93599 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAI16226.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI22075.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for SYCP2L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SYCP2L Gene

Proteomics data for SYCP2L Gene at MOPED

Post-translational modifications for SYCP2L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SYCP2L Gene

No data available for DME Specific Peptides for SYCP2L Gene

Domains & Families for SYCP2L Gene

Protein Domains for SYCP2L Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SYCP2L Gene

Graphical View of Domain Structure for InterPro Entry

Q5T4T6

UniProtKB/Swiss-Prot:

SYC2L_HUMAN :
  • Belongs to the SYCP2 family.
Family:
  • Belongs to the SYCP2 family.
genes like me logo Genes that share domains with SYCP2L: view

No data available for Gene Families for SYCP2L Gene

Function for SYCP2L Gene

genes like me logo Genes that share phenotypes with SYCP2L: view

Animal Model Products

CRISPR Products

miRNA for SYCP2L Gene

miRTarBase miRNAs that target SYCP2L

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SYCP2L Gene

Localization for SYCP2L Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYCP2L Gene

Nucleus. Note=Detected in nuclear granules and sizable aggregates.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SYCP2L Gene COMPARTMENTS Subcellular localization image for SYCP2L gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for SYCP2L Gene

Pathways & Interactions for SYCP2L Gene

SuperPathways for SYCP2L Gene

No Data Available

Interacting Proteins for SYCP2L Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000283141%0d%0a9606.ENSP00000266743%0d%0a
Selected Interacting proteins: ENSP00000283141 for SYCP2L Gene via STRING

Symbol External ID(s) Details
SYCP3

Gene Ontology (GO) - Biological Process for SYCP2L Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SYCP2L Gene

Drugs & Compounds for SYCP2L Gene

No Compound Related Data Available

Transcripts for SYCP2L Gene

mRNA/cDNA for SYCP2L Gene

Unigene Clusters for SYCP2L Gene

Synaptonemal complex protein 2-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SYCP2L Gene

No ASD Table

Relevant External Links for SYCP2L Gene

GeneLoc Exon Structure for
SYCP2L
ECgene alternative splicing isoforms for
SYCP2L

Expression for SYCP2L Gene

mRNA expression in normal human tissues for SYCP2L Gene

mRNA differential expression in normal tissues according to GTEx for SYCP2L Gene

This gene is overexpressed in Testis (x4.4).

Protein differential expression in normal tissues from HIPED for SYCP2L Gene

This gene is overexpressed in Neutrophil (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SYCP2L Gene



SOURCE GeneReport for Unigene cluster for SYCP2L Gene Hs.729128

mRNA Expression by UniProt/SwissProt for SYCP2L Gene

Q5T4T6-SYC2L_HUMAN
Tissue specificity: Expressed in the ovary (at protein level).
genes like me logo Genes that share expression patterns with SYCP2L: view

Protein tissue co-expression partners for SYCP2L Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SYCP2L Gene

Orthologs for SYCP2L Gene

This gene was present in the common ancestor of chordates.

Orthologs for SYCP2L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SYCP2L 35
  • 99.34 (n)
  • 98.89 (a)
SYCP2L 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SYCP2L 36
  • 61 (a)
OneToOne
SYCP2L 35
  • 79 (n)
  • 68.31 (a)
dog
(Canis familiaris)
Mammalia SYCP2L 35
  • 80.34 (n)
  • 68.33 (a)
SYCP2L 36
  • 65 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sycp2l 36
  • 63 (a)
OneToOne
Sycp2l 35
  • 67.56 (n)
  • 52.01 (a)
oppossum
(Monodelphis domestica)
Mammalia SYCP2L 36
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SYCP2L 36
  • 54 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sycp2l 35
  • 63.36 (n)
  • 53.27 (a)
chicken
(Gallus gallus)
Aves SYCP2L 36
  • 30 (a)
OneToOne
SYCP2L 35
  • 63.09 (n)
  • 54.19 (a)
lizard
(Anolis carolinensis)
Reptilia SYCP2L 36
  • 24 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia NO145 35
tropical clawed frog
(Silurana tropicalis)
Amphibia sycp2l 35
  • 56.49 (n)
  • 46.07 (a)
zebrafish
(Danio rerio)
Actinopterygii sycp2l 36
  • 25 (a)
OneToOne
sycp2l 35
  • 50 (n)
  • 35.94 (a)
Species with no ortholog for SYCP2L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SYCP2L Gene

ENSEMBL:
Gene Tree for SYCP2L (if available)
TreeFam:
Gene Tree for SYCP2L (if available)

Paralogs for SYCP2L Gene

Paralogs for SYCP2L Gene

(1) SIMAP similar genes for SYCP2L Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SYCP2L: view

Variants for SYCP2L Gene

Sequence variations from dbSNP and Humsavar for SYCP2L Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs6456746 - 10,894,148(+) TCCTC(A/G/T)TAGAT reference, missense
VAR_043170 -
VAR_043171 -
VAR_069417 -
rs1225758 -- 10,923,143(+) TTTTT(C/T)CCCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SYCP2L Gene

Variant ID Type Subtype PubMed ID
nsv519302 CNV Loss 19592680
nsv348982 CNV Loss 16902084
nsv519009 CNV Loss 19592680
esv2506207 CNV Insertion 19546169

Variation tolerance for SYCP2L Gene

Residual Variation Intolerance Score: 56% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.63; 78.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SYCP2L Gene

HapMap Linkage Disequilibrium report
SYCP2L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SYCP2L Gene

Disorders for SYCP2L Gene

Relevant External Links for SYCP2L

Genetic Association Database (GAD)
SYCP2L
Human Genome Epidemiology (HuGE) Navigator
SYCP2L
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SYCP2L

No disorders were found for SYCP2L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SYCP2L Gene

Publications for SYCP2L Gene

  1. Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. (PMID: 22267201) Stolk L. … Lunetta K.L. (Nat. Genet. 2012) 3 48 67
  2. Integrated genome-wide association, coexpression network, and expression single nucleotide polymorphism analysis identifies novel pathway in allergic rhinitis. (PMID: 25085501) Bunyavanich S. … Weiss S.T. (BMC Med Genomics 2014) 3
  3. Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality. (PMID: 24159190) SeppAolAo I. … LehtimAoki T. (Eur. Heart J. 2014) 3
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  5. Genetic loci associated with plasma phospholipid n-3 fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium. (PMID: 21829377) Lemaitre R.N. … Steffen L.M. (PLoS Genet. 2011) 3

Products for SYCP2L Gene

Sources for SYCP2L Gene

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