Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SYCP2L Gene

Aliases for SYCP2L Gene

  • Synaptonemal Complex Protein 2-Like 2 3
  • 145 KDa Nucleolar Protein Homolog 3 4
  • SCP-2-Like 3 4
  • C6orf177 3 4
  • NO145 3 4
  • Chromosome 6 Open Reading Frame 177 2
  • DJ62D2.1 3
  • HsNO145 4

External Ids for SYCP2L Gene

Previous Symbols for SYCP2L Gene

  • C6orf177

Summaries for SYCP2L Gene

GeneCards Summary for SYCP2L Gene

SYCP2L (Synaptonemal Complex Protein 2-Like) is a Protein Coding gene. An important paralog of this gene is SYCP2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYCP2L Gene

Genomics for SYCP2L Gene

Genomic Location for SYCP2L Gene

Start:
10,886,831 bp from pter
End:
10,979,320 bp from pter
Size:
92,490 bases
Orientation:
Plus strand

Genomic View for SYCP2L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SYCP2L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYCP2L Gene

Regulatory Elements for SYCP2L Gene

Proteins for SYCP2L Gene

  • Protein details for SYCP2L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T4T6-SYC2L_HUMAN
    Recommended name:
    Synaptonemal complex protein 2-like
    Protein Accession:
    Q5T4T6
    Secondary Accessions:
    • A6NDS5
    • Q08GK5
    • Q6ZRM2
    • Q96EJ2

    Protein attributes for SYCP2L Gene

    Size:
    812 amino acids
    Molecular mass:
    93599 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAI16226.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI22075.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for SYCP2L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SYCP2L Gene

Proteomics data for SYCP2L Gene at MOPED

Post-translational modifications for SYCP2L Gene

No Post-translational modifications

Other Protein References for SYCP2L Gene

No data available for DME Specific Peptides for SYCP2L Gene

Domains for SYCP2L Gene

Protein Domains for SYCP2L Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

SYC2L_HUMAN
Family:
  • Belongs to the SYCP2 family.:
    • Q5T4T6
genes like me logo Genes that share domains with SYCP2L: view

No data available for Gene Families for SYCP2L Gene

Function for SYCP2L Gene

Phenotypes for SYCP2L Gene

GenomeRNAi human phenotypes for SYCP2L:
genes like me logo Genes that share phenotypes with SYCP2L: view

miRNA for SYCP2L Gene

miRTarBase miRNAs that target SYCP2L

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for SYCP2L Gene

Localization for SYCP2L Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYCP2L Gene

Nucleus. Note=Detected in nuclear granules and sizable aggregates.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SYCP2L Gene COMPARTMENTS Subcellular localization image for SYCP2L gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for SYCP2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with SYCP2L: view

Pathways for SYCP2L Gene

SuperPathways for SYCP2L Gene

No Data Available

Interacting Proteins for SYCP2L Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000283141%0d%0a9606.ENSP00000266743%0d%0a
Selected Interacting proteins: ENSP00000283141 for SYCP2L Gene via STRING

Symbol External ID(s) Details
SYCP3

Gene Ontology (GO) - Biological Process for SYCP2L Gene

None

No data available for Pathways by source for SYCP2L Gene

Transcripts for SYCP2L Gene

mRNA/cDNA for SYCP2L Gene

Unigene Clusters for SYCP2L Gene

Synaptonemal complex protein 2-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SYCP2L Gene

No ASD Table

Relevant External Links for SYCP2L Gene

GeneLoc Exon Structure for
SYCP2L
ECgene alternative splicing isoforms for
SYCP2L

Expression for SYCP2L Gene

mRNA expression in normal human tissues for SYCP2L Gene

mRNA differential expression in normal tissues according to GTEx for SYCP2L Gene

This gene is overexpressed in Testis (4.4).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SYCP2L Gene

SOURCE GeneReport for Unigene cluster for SYCP2L Gene Hs.729128

mRNA Expression by UniProt/SwissProt for SYCP2L Gene

Q5T4T6-SYC2L_HUMAN
Tissue specificity: Expressed in the ovary (at protein level).
genes like me logo Genes that share expressions with SYCP2L: view

Orthologs for SYCP2L Gene

This gene was present in the common ancestor of chordates.

Orthologs for SYCP2L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SYCP2L 36
  • 99.34 (n)
  • 98.89 (a)
SYCP2L 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SYCP2L 36
  • 79 (n)
  • 68.31 (a)
SYCP2L 37
  • 61 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SYCP2L 36
  • 80.34 (n)
  • 68.33 (a)
SYCP2L 37
  • 65 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sycp2l 36
  • 67.56 (n)
  • 52.01 (a)
Sycp2l 16
Sycp2l 37
  • 63 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SYCP2L 37
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SYCP2L 37
  • 54 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sycp2l 36
  • 63.36 (n)
  • 53.27 (a)
chicken
(Gallus gallus)
Aves SYCP2L 36
  • 63.09 (n)
  • 54.19 (a)
SYCP2L 37
  • 30 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SYCP2L 37
  • 24 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia NO145 36
tropical clawed frog
(Silurana tropicalis)
Amphibia sycp2l 36
  • 56.49 (n)
  • 46.07 (a)
zebrafish
(Danio rerio)
Actinopterygii sycp2l 36
  • 50 (n)
  • 35.94 (a)
sycp2l 37
  • 25 (a)
OneToOne
Species with no ortholog for SYCP2L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SYCP2L Gene

ENSEMBL:
Gene Tree for SYCP2L (if available)
TreeFam:
Gene Tree for SYCP2L (if available)

Paralogs for SYCP2L Gene

Paralogs for SYCP2L Gene

Selected SIMAP similar genes for SYCP2L Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SYCP2L: view

Variants for SYCP2L Gene

Sequence variations from dbSNP and Humsavar for SYCP2L Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs946350 -- 10,892,720(+) ggacc(C/G)tggta intron-variant
rs946351 -- 10,892,887(+) GCTGT(A/G)TATAG intron-variant
rs1150561 -- 10,963,614(+) AATCA(A/G)ATGAA intron-variant
rs1225726 -- 10,929,877(+) AGAGG(A/T)TACAG intron-variant
rs1225727 -- 10,929,896(+) GATGG(C/T)GCCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SYCP2L Gene

Variant ID Type Subtype PubMed ID
nsv519302 CNV Loss 19592680
nsv348982 CNV Loss 16902084
nsv519009 CNV Loss 19592680
esv2506207 CNV Insertion 19546169

Relevant External Links for SYCP2L Gene

HapMap Linkage Disequilibrium report
SYCP2L

Disorders for SYCP2L Gene

Relevant External Links for SYCP2L

Genetic Association Database (GAD)
SYCP2L
Human Genome Epidemiology (HuGE) Navigator
SYCP2L
genes like me logo Genes that share disorders with SYCP2L: view

No data available for UniProtKB/Swiss-Prot for SYCP2L Gene

Publications for SYCP2L Gene

  1. Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. (PMID: 22267201) Stolk L. … Lunetta K.L. (Nat. Genet. 2012) 3 49
  2. Genome-wide association studies identify loci associated with age at menarche and age at natural menopause. (PMID: 19448621) He C. … Chasman D.I. (Nat. Genet. 2009) 3 49
  3. Genetic loci associated with plasma phospholipid n-3 fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium. (PMID: 21829377) Lemaitre R.N. … Steffen L.M. (PLoS Genet. 2011) 3 49
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for SYCP2L Gene

Sources for SYCP2L Gene

Back to Top

Content