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Aliases for SYCP2 Gene

Aliases for SYCP2 Gene

  • Synaptonemal Complex Protein 2 2 3 5
  • Synaptonemal Complex Lateral Element Protein 3 4
  • SCP-2 3 4
  • SCP2 3 4
  • HsSCP2 4

External Ids for SYCP2 Gene

Previous GeneCards Identifiers for SYCP2 Gene

  • GC20M058167
  • GC20M059077
  • GC20M059124
  • GC20M057872
  • GC20M058438
  • GC20M055225

Summaries for SYCP2 Gene

Entrez Gene Summary for SYCP2 Gene

  • The synaptonemal complex is a proteinaceous structure that links homologous chromosomes during the prophase of meiosis. The protein encoded by this gene is a major component of the synaptonemal complex and may bind DNA at scaffold attachment regions. The encoded protein requires synaptonemal complex protein 3, but not 1, for inclusion in the synaptonemal complex. [provided by RefSeq, Jul 2008]

GeneCards Summary for SYCP2 Gene

SYCP2 (Synaptonemal Complex Protein 2) is a Protein Coding gene. Among its related pathways are Meiosis and Cell Cycle, Mitotic. GO annotations related to this gene include protein heterodimerization activity. An important paralog of this gene is SYCP2L.

UniProtKB/Swiss-Prot for SYCP2 Gene

  • Major component of the axial/lateral elements of synaptonemal complexes (SCS) during meiotic prophase. Plays a role in the assembly of synaptonemal complexes. Required for normal meiotic chromosome synapsis during oocyte and spermatocyte development and for normal male and female fertility. Required for insertion of SYCP3 into synaptonemal complexes. May be involved in the organization of chromatin by temporarily binding to DNA scaffold attachment regions. Requires SYCP3, but not SYCP1, in order to be incorporated into the axial/lateral elements.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYCP2 Gene

Genomics for SYCP2 Gene

Regulatory Elements for SYCP2 Gene

Enhancers for SYCP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20F059876 0.7 FANTOM5 7.8 +57.1 57132 0.4 FAM217B SYCP2 PPP1R3D RNU7-141P
GH20F059861 0.7 FANTOM5 3 +72.1 72057 0.3 PKNOX1 PHACTR3 FAM217B SYCP2 RNU7-141P
GH20F060054 1.1 FANTOM5 ENCODE 2 -123.3 -123309 4.8 INSM2 YBX1 FEZF1 RAD21 GLIS2 SCRT2 ZNF143 FOS ZNF263 ZNF654 C20orf197 PPP1R3D FAM217B SYCP2 ENSG00000276093
GH20F059931 0.4 ENCODE 0.8 +1.9 1859 1.4 SP1 ZNF687 GLIS1 FEZF1 ZBTB33 ZNF600 TRIM28 SYCP2 RNU7-141P
GH20F059926 0.2 ENCODE 0.4 +7.6 7561 0.2 RFX1 ZHX2 DPF2 ZBTB40 RAD21 ZNF217 CTBP1 JUND CBX1 GATA3 SYCP2 RNU7-141P
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SYCP2 on UCSC Golden Path with GeneCards custom track

Promoters for SYCP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001450181 -319 1200 HDGF CREB3L1 ARID4B SIN3A ZNF48 GLIS2 ELK1 ZNF143 ZNF207 FOS

Genomic Location for SYCP2 Gene

Chromosome:
20
Start:
59,863,557 bp from pter
End:
59,933,681 bp from pter
Size:
70,125 bases
Orientation:
Minus strand

Genomic View for SYCP2 Gene

Genes around SYCP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SYCP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SYCP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYCP2 Gene

Proteins for SYCP2 Gene

  • Protein details for SYCP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BX26-SYCP2_HUMAN
    Recommended name:
    Synaptonemal complex protein 2
    Protein Accession:
    Q9BX26
    Secondary Accessions:
    • A2RUE5
    • O75763
    • Q5JX11
    • Q9NTX8
    • Q9UG27

    Protein attributes for SYCP2 Gene

    Size:
    1530 amino acids
    Molecular mass:
    175639 Da
    Quaternary structure:
    • Component of the lateral elements of synaptonemal complexes. Heterodimer with SYCP3 (By similarity). Interacts with SMC1A and SMC3 (By similarity). Interacts with TEX11 (By similarity).

neXtProt entry for SYCP2 Gene

Post-translational modifications for SYCP2 Gene

No data available for DME Specific Peptides for SYCP2 Gene

Domains & Families for SYCP2 Gene

Protein Domains for SYCP2 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9BX26

UniProtKB/Swiss-Prot:

SYCP2_HUMAN :
  • Belongs to the SYCP2 family.
Family:
  • Belongs to the SYCP2 family.
genes like me logo Genes that share domains with SYCP2: view

No data available for Gene Families for SYCP2 Gene

Function for SYCP2 Gene

Molecular function for SYCP2 Gene

GENATLAS Biochemistry:
synaptonemal complex protein 2,axial element homolog to mouse Scp2,DNA binding protein,involved in the structural organization of meiotic prophase chromosomes
UniProtKB/Swiss-Prot Function:
Major component of the axial/lateral elements of synaptonemal complexes (SCS) during meiotic prophase. Plays a role in the assembly of synaptonemal complexes. Required for normal meiotic chromosome synapsis during oocyte and spermatocyte development and for normal male and female fertility. Required for insertion of SYCP3 into synaptonemal complexes. May be involved in the organization of chromatin by temporarily binding to DNA scaffold attachment regions. Requires SYCP3, but not SYCP1, in order to be incorporated into the axial/lateral elements.

Gene Ontology (GO) - Molecular Function for SYCP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding NAS 10341103
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with SYCP2: view
genes like me logo Genes that share phenotypes with SYCP2: view

Animal Models for SYCP2 Gene

MGI Knock Outs for SYCP2:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SYCP2 Gene

Localization for SYCP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYCP2 Gene

Nucleus. Chromosome. Note=In axial/lateral elements of the tripartite segments of synaptonemal complexes. {ECO:0000250 UniProtKB:Q9CUU3}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SYCP2 Gene COMPARTMENTS Subcellular localization image for SYCP2 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for SYCP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000795 synaptonemal complex NAS 10341103
GO:0000800 lateral element ISS --
GO:0005634 nucleus NAS 10341103
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with SYCP2: view

Pathways & Interactions for SYCP2 Gene

SuperPathways for SYCP2 Gene

SuperPathway Contained pathways
1 Meiosis
.73
2 Cell Cycle, Mitotic
genes like me logo Genes that share pathways with SYCP2: view

Pathways by source for SYCP2 Gene

3 Reactome pathways for SYCP2 Gene

Gene Ontology (GO) - Biological Process for SYCP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0007130 synaptonemal complex assembly NAS 10341103
GO:0007140 male meiosis IEA --
GO:0007143 female meiotic division IEA --
GO:0009566 fertilization IEA --
genes like me logo Genes that share ontologies with SYCP2: view

No data available for SIGNOR curated interactions for SYCP2 Gene

Transcripts for SYCP2 Gene

Unigene Clusters for SYCP2 Gene

Synaptonemal complex protein 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SYCP2 Gene

No ASD Table

Relevant External Links for SYCP2 Gene

GeneLoc Exon Structure for
SYCP2
ECgene alternative splicing isoforms for
SYCP2

Expression for SYCP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SYCP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SYCP2 Gene

This gene is overexpressed in Testis (x10.4).

Protein differential expression in normal tissues from HIPED for SYCP2 Gene

This gene is overexpressed in Testis (24.9), Ovary (15.1), Platelet (12.5), and Heart (10.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SYCP2 Gene



Protein tissue co-expression partners for SYCP2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SYCP2 Gene:

SYCP2

SOURCE GeneReport for Unigene cluster for SYCP2 Gene:

Hs.202676
genes like me logo Genes that share expression patterns with SYCP2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for SYCP2 Gene

Orthologs for SYCP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SYCP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SYCP2 34 35
  • 99.24 (n)
dog
(Canis familiaris)
Mammalia SYCP2 34 35
  • 85.17 (n)
cow
(Bos Taurus)
Mammalia SYCP2 34 35
  • 84.94 (n)
mouse
(Mus musculus)
Mammalia Sycp2 34 16 35
  • 77.91 (n)
rat
(Rattus norvegicus)
Mammalia Sycp2 34
  • 77.76 (n)
oppossum
(Monodelphis domestica)
Mammalia SYCP2 35
  • 51 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 51 (a)
OneToMany
-- 35
  • 35 (a)
OneToMany
chicken
(Gallus gallus)
Aves SYCP2 34 35
  • 58.15 (n)
lizard
(Anolis carolinensis)
Reptilia SYCP2 35
  • 44 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sycp2 34
  • 54.54 (n)
zebrafish
(Danio rerio)
Actinopterygii sycp2 35
  • 15 (a)
OneToOne
Species where no ortholog for SYCP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SYCP2 Gene

ENSEMBL:
Gene Tree for SYCP2 (if available)
TreeFam:
Gene Tree for SYCP2 (if available)

Paralogs for SYCP2 Gene

Paralogs for SYCP2 Gene

(1) SIMAP similar genes for SYCP2 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for SYCP2 Gene

genes like me logo Genes that share paralogs with SYCP2: view

Variants for SYCP2 Gene

Sequence variations from dbSNP and Humsavar for SYCP2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs193921008 Uncertain significance 59,886,842(-) CAATT(C/T)TTTTC intron-variant
rs10222013 -- 59,876,470(+) GGTAA(A/G)AGATA intron-variant
rs10222014 -- 59,876,477(+) GATAA(A/G)ATTGC intron-variant
rs1022654 -- 59,934,882(-) TCTGA(G/T)AGCTT intron-variant, upstream-variant-2KB
rs10557809 -- 59,876,022(+) GGGAT(-/AAGAT)GAGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SYCP2 Gene

Variant ID Type Subtype PubMed ID
dgv4335n100 CNV loss 25217958
dgv4336n100 CNV loss 25217958
dgv4337n100 CNV loss 25217958
nsv1062669 CNV loss 25217958
nsv1065994 CNV loss 25217958
nsv586370 CNV loss 21841781
nsv586371 CNV loss 21841781
nsv955145 CNV duplication 24416366

Variation tolerance for SYCP2 Gene

Residual Variation Intolerance Score: 96.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.49; 64.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SYCP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SYCP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SYCP2 Gene

Disorders for SYCP2 Gene

Relevant External Links for SYCP2

Genetic Association Database (GAD)
SYCP2
Human Genome Epidemiology (HuGE) Navigator
SYCP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SYCP2

No disorders were found for SYCP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SYCP2 Gene

Publications for SYCP2 Gene

  1. Isolation and characterization of the human SCP2 cDNA and chromosomal localization of the gene. (PMID: 10341103) Schalk J.A. … Heyting C. (Mamm. Genome 1999) 2 3 4 64
  2. Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent. (PMID: 20378615) Aston K.I. … Carrell D.T. (Hum. Reprod. 2010) 3 46 64
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4 64
  4. SCP2: a major protein component of the axial elements of synaptonemal complexes of the rat. (PMID: 9592139) Offenberg H.H. … Heyting C. (Nucleic Acids Res. 1998) 2 3 64
  5. SR protein kinases promote splicing of nonconsensus introns. (PMID: 26167880) Lipp J.J. … Guthrie C. (Nat. Struct. Mol. Biol. 2015) 3 64

Products for SYCP2 Gene

Sources for SYCP2 Gene

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