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SYCP2 Gene

protein-coding   GIFtS: 54
GCID: GC20M058438

Synaptonemal Complex Protein 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Synaptonemal Complex Protein 21 2
SCP22 3 5
Synaptonemal Complex Lateral Element Protein2 3
SCP-22 3
hsSCP22 3

External Ids:    HGNC: 114901   Entrez Gene: 103882   Ensembl: ENSG000001960747   OMIM: 6041055   UniProtKB: Q9BX263   

Export aliases for SYCP2 gene to outside databases

Previous GC identifers: GC20M058167 GC20M059077 GC20M059124 GC20M057872 GC20M055225


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SYCP2 Gene:
The synaptonemal complex is a proteinaceous structure that links homologous chromosomes during the prophase of
meiosis. The protein encoded by this gene is a major component of the synaptonemal complex and may bind DNA at
scaffold attachment regions. The encoded protein requires synaptonemal complex protein 3, but not 1, for
inclusion in the synaptonemal complex. (provided by RefSeq, Jul 2008)

GeneCards Summary for SYCP2 Gene:
SYCP2 (synaptonemal complex protein 2) is a protein-coding gene. GO annotations related to this gene include protein heterodimerization activity. An important paralog of this gene is SYCP2L.

UniProtKB/Swiss-Prot: SYCP2_HUMAN, Q9BX26
Function: Major component of the axial/lateral elements of synaptonemal complexes (SCS) during meiotic prophase.
May be involved in the organization of chromatin by temporarily binding to DNA scaffold attachment regions.
Requires SYCP3, but not SYCP1, in order to be incorporated into the axial/lateral elements (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NT_011362.11  NC_018931.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SYCP2 gene promoter:
         ER-alpha   AhR   USF2   Olf-1   USF-1:USF-2   Arnt   E2F-1   E2F   POU2F1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SYCP2 promoter sequence
   Search Chromatin IP Primers for SYCP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SYCP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.33   Ensembl cytogenetic band:  20q13.33   HGNC cytogenetic band: 20q13.33

SYCP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SYCP2 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M058438:  view genomic region     (about GC identifiers)

Start:
58,438,618 bp from pter      End:
58,508,710 bp from pter
Size:
70,093 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SYCP2_HUMAN, Q9BX26 (See protein sequence)
Recommended Name: Synaptonemal complex protein 2  
Size: 1530 amino acids; 175639 Da
Subunit: Heterodimer with SYCP3. Interacts with SYCP3, SMC1A and SMC3. Interacts with TEX11 (By similarity)
Secondary accessions: A2RUE5 O75763 Q5JX11 Q9NTX8 Q9UG27

Explore the universe of human proteins at neXtProt for SYCP2: NX_Q9BX26

Explore proteomics data for SYCP2 at MOPED

Post-translational modifications: 

  • Phosphorylated (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SYCP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055073.2  
    ENSEMBL proteins: 
     ENSP00000350162   ENSP00000404358   ENSP00000402456   ENSP00000399300   ENSP00000360040  
    Reactome Protein details: Q9BX26

    SYCP2 Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SYCP2

     
    Search eBioscience for Proteins for SYCP2 

    SYCP2 Antibody Products:

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    LSBio Antibodies in human, mouse, rat for SYCP2

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    Cloud-Clone Corp. ELISAs for SYCP2
    Cloud-Clone Corp. CLIAs for SYCP2
    Search eBioscience for ELISAs for SYCP2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR024835 SYCP2/SYCP2-like
     IPR024832 SYCP2

    Graphical View of Domain Structure for InterPro Entry Q9BX26

    ProtoNet protein and cluster: Q9BX26

    UniProtKB/Swiss-Prot: SYCP2_HUMAN, Q9BX26
    Similarity: Belongs to the SYCP2 family


    Find genes that share domains with SYCP2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SYCP2_HUMAN, Q9BX26
    Function: Major component of the axial/lateral elements of synaptonemal complexes (SCS) during meiotic prophase.
    May be involved in the organization of chromatin by temporarily binding to DNA scaffold attachment regions.
    Requires SYCP3, but not SYCP1, in order to be incorporated into the axial/lateral elements (By similarity)

         Genatlas biochemistry entry for SYCP2:
    synaptonemal complex protein 2,axial element homolog to mouse Scp2,DNA binding protein,involved in the structural
    organization of meiotic prophase chromosomes

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding NAS10341103
    GO:0005515protein binding ----
    GO:0046982protein heterodimerization activity IEA--
         
    Find genes that share ontologies with SYCP2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SYCP2:
     Increased circadian rhythm amp 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Sycp2):
     cellular  endocrine/exocrine gland  reproductive system 

    Find genes that share phenotypes with SYCP2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Sycp2tm1Jw for SYCP2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SYCP2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SYCP2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SYCP2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SYCP2

    miRNA
    Products:
        
    miRTarBase miRNAs that target SYCP2:
    hsa-mir-26b-5p (MIRT030161), hsa-mir-1260b (MIRT052762), hsa-mir-769-5p (MIRT016091)

    Block miRNA regulation of human, mouse, rat SYCP2 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate SYCP2:
    hsa-miR-1305
    SwitchGear 3'UTR luciferase reporter plasmidSYCP2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SYCP2
    Predesigned siRNA for gene silencing in human, mouse, rat SYCP2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SYCP2

    Clone
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    OriGene clones in human, mouse for SYCP2 (see all 7)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SYCP2 (NM_014258)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SYCP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYCP2

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for SYCP2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYCP2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SYCP2_HUMAN, Q9BX26: Nucleus (By similarity). Chromosome (By similarity). Note=In axial/lateral elements of the
    tripartite segments of synaptonemal complexes (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000795synaptonemal complex NAS10341103
    GO:0000800lateral element IEA--
    GO:0005634nucleus NAS10341103

    Find genes that share ontologies with SYCP2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SYCP2 About    
    See pathways by source

    SuperPathContained pathways About
    1Packaging Of Telomere Ends
    Meiotic Synapsis0.66
    Chromosome Maintenance0.62
    2Cell Cycle, Mitotic
    Cell Cycle0.90
    3Meiosis (REACTOME)
    Meiosis0.74
    4Meiosis (EMD)
    Meiosis


    Find genes that share SuperPaths with SYCP2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for SYCP2
        Meiotic synapsis


        Pathway & Disease-focused RT2 Profiler PCR Arrays including SYCP2: 
              Necrosis in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Cell Death PathwayFinder in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for SYCP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    Selected Interacting proteins for SYCP2 (Q9BX263 ENSP000003501624) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SYCP3Q8IZU33, ENSP000002667434I2D: score=1 STRING: ENSP00000266743
    BRCA1ENSP000003502834STRING: ENSP00000350283
    RAD21ENSP000002973384STRING: ENSP00000297338
    STAG2ENSP000002180894STRING: ENSP00000218089
    SYCE1ENSP000003412824STRING: ENSP00000341282
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process ----
    GO:0007128meiotic prophase I NAS9592139
    GO:0007130synaptonemal complex assembly NAS10341103
    GO:0007140male meiosis IEA--
    GO:0007143female meiosis IEA--

    Find genes that share ontologies with SYCP2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SYCP2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SYCP2 gene: 
    NM_014258.2  

    Unigene Cluster for SYCP2:

    Synaptonemal complex protein 2
    Hs.202676  [show with all ESTs]
    Unigene Representative Sequence: NM_014258
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000357552 ENST00000412613 ENST00000446834(uc010gju.1) ENST00000474749
    ENST00000461538 ENST00000471331 ENST00000476314 ENST00000425931 ENST00000371001(uc002yaz.3)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SYCP2 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate SYCP2:
    hsa-miR-1305
    SwitchGear 3'UTR luciferase reporter plasmidSYCP2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SYCP2
    Predesigned siRNA for gene silencing in human, mouse, rat SYCP2
    Clone
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    GenScript: all cDNA clones in your preferred vector: SYCP2 (NM_014258)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SYCP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYCP2
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for SYCP2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SYCP2
      QuantiTect SYBR Green Assays in human, mouse, rat SYCP2
      QuantiFast Probe-based Assays in human, mouse, rat SYCP2

    Additional mRNA sequence: 

    AK308889.1 AL080226.1 BC040566.1 BC132864.1 BC132870.1 BC146798.1 BX648091.1 BX649108.1 
    Y08982.1 

    8 DOTS entries:

    DT.91808642  DT.204422  DT.101985096  DT.120818505  DT.91753747  DT.100777091  DT.40250001  DT.95359109 

    Selected AceView cDNA sequences (see all 55):

    AL080226 BM722901 NM_014258 BX114874 BX497862 AA398450 AI439713 BC040566 
    BM677372 C05195 CD171875 H04007 AW118105 BI063905 CA454645 BX649108 
    BX492597 AI678059 AA554180 Y08982 AL703983 BG215648 CD358264 BU687047 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SYCP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAGAAATGC
    SYCP2 Expression
    About this image


    SYCP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Gonad
             XY Germ Cells Testis Cord
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             XY Germ Cells Testis Cord
     
     Ovary (Reproductive System)
             XX Germ Cells Ovigerous Cord
     
     Breast (Uncategorized)
     
     Stomach (Gastrointestinal Tract)
    SYCP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SYCP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.202676
        Pathway & Disease-focused RT2 Profiler PCR Arrays including SYCP2: 
              Necrosis in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Cell Death PathwayFinder in human mouse rat

    Primer
    Products:
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYCP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SYCP2 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sycp21 , 5 synaptonemal complex protein 21, 5 77.91(n)1
    64.79(a)1
      2 (99.81 cM)5
    3205581  NM_177191.31  NP_796165.21 
     1783452935 
    chicken
    (Gallus gallus)
    Aves SYCP21 synaptonemal complex protein 2 58.15(n)
    42.01(a)
      419219  XM_417396.4  XP_417396.4 
    lizard
    (Anolis carolinensis)
    Reptilia SYCP26
    synaptonemal complex protein 2
    44(a)
    1 ↔ 1
    4(148031246-148055444)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia sycp21 synaptonemal complex protein 2 54.54(n)
    40.54(a)
      779792  NM_001078871.1  NP_001072339.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sycp26
    synaptonemal complex protein 2
    15(a)
    1 ↔ 1
    23(12304470-12334591) ENSDARG00000088950


    ENSEMBL Gene Tree for SYCP2 (if available)
    TreeFam Gene Tree for SYCP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SYCP2 gene
    SYCP2L2  
    1 SIMAP similar gene for SYCP2 using alignment to 6 protein entries:     SYCP2_HUMAN (see all proteins):
    SYCP2L

    Find genes that share paralogs with SYCP2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for SYCP2
    PGOHUM00000247570


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SYCP2 (see all 1721)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1876330201,2
    --58438128(+) GGAAAC/TTGAGG 1 -- ds50010--------
    rs1420513211,2
    --58438152(+) AACTGC/GTGGTA 1 -- ds50010--------
    rs1899678381,2
    --58438155(+) TGCTGC/GTAATG 1 -- ds50010--------
    rs1816172911,2
    --58438162(+) AATGAA/TAGGAT 1 -- ds50010--------
    rs13274671,2
    F--58438252(-) gactcC/Ttaaat 1 -- ds50010--------
    rs766986741,2
    C,F--58438274(+) GCTGAC/TGATGA 1 -- ds50011Minor allele frequency- T:0.01NA 120
    rs1900076531,2
    --58438275(+) CTGACC/GATGAG 1 -- ds50010--------
    rs1447547971,2
    --58438306(+) TGATGC/GAATTA 1 -- ds50010--------
    rs1485336101,2
    --58438394(+) ACCCCA/GCTACT 1 -- ds50010--------
    rs1825458181,2
    --58438456(+) GAGAAG/TGGTTT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for SYCP2 (58438618 - 58508710 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SYCP2:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv4584n71CNV Loss21882294
    dgv4583n71CNV Loss21882294
    nsv912968CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SYCP2
    DNA2.0 Custom Variant and Variant Library Synthesis for SYCP2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604105    OMIM disorders: --


    Find genes that share disorders with SYCP2           About GenesLikeMe

    Genetic Association Database (GAD): SYCP2
    Human Genome Epidemiology (HuGE) Navigator: SYCP2 (1 document)

    Export disorders for SYCP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SYCP2 gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with SYCP2)
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    1. Isolation and characterization of the human SCP2 cDNA and chromosomal localization of the gene. (PubMed id 10341103)1, 2, 3 Schalk J.A....Heyting C. (Mamm. Genome 1999)
    2. Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent. (PubMed id 20378615)1, 4 Aston K.I....Carrell D.T. (Hum. Reprod. 2010)
    3. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    4. SCP2: a major protein component of the axial elements of synaptonemal complexes of the rat. (PubMed id 9592139)1, 3 Offenberg H.H....Heyting C. (Nucleic Acids Res. 1998)
    5. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    8. Synaptonemal complex proteins: occurrence, epitope mapping and chromosome disjunction. (PubMed id 7876343)9 Dobson M.J....Moens P.B. (J. Cell. Sci. 1994)
    9. The Puf RNA-binding proteins FBF-1 and FBF-2 inhibit the expression of synaptonemal complex proteins in germline stem cells. (PubMed id 20431119)9 Merritt C. and Seydoux G. (Development 2010)
    10. Wapl localization on the synaptonemal complex, a meiosis-specific proteinaceous structure that binds homologous chromosomes, in the female mouse. (PubMed id 18199270)9 Zhang J....Yuan L. (Reprod. Domest. Anim. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10388 HGNC: 11490 AceView: SYCP2 Ensembl:ENSG00000196074 euGenes: HUgn10388
    ECgene: SYCP2 H-InvDB: SYCP2

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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SYCP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SYCP2 gene:
    Search GeneIP for patents involving SYCP2

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