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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SYCP1 Gene

protein-coding   GIFtS: 56
GCID: GC01P115397

synaptonemal complex protein 1
 Explore 15 diseases affiliated with
SYCP1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SYCP1    

Aliases
for SYCP1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Synaptonemal Complex Protein 11 2
SCP11 2 3 5
CT81 2 3
HOM-TES-141 2
Cancer/Testis Antigen 82 3
SCP-12 3

External Ids:    HGNC: 114871   Entrez Gene: 68472   Ensembl: ENSG000001987657   OMIM: 6021625   UniProtKB: Q154313   

Export aliases for SYCP1 gene to outside databases

Previous GC identifers: GC01P115810 GC01P114279 GC01P114497 GC01P114696 GC01P115109 GC01P115198 GC01P113255


Summaries
for SYCP1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: SYCP1_HUMAN, Q15431
Function: Major component of the transverse filaments of synaptonemal complexes (SCS), formed between homologous
chromosomes during meiotic prophase

Gene Wiki entry for SYCP1


Genomic Views
for SYCP1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SYCP1 gene promoter:
         COUP-TF1   AML1a   HTF   COUP   HNF-4alpha2   IRF-1   E4BP4   HNF-4alpha1   COUP-TF   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SYCP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SYCP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SYCP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13-p12   Ensembl cytogenetic band:  1p13.2   HGNC cytogenetic band: 1p13-p12

SYCP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SYCP1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P115397:  view genomic region     (about GC identifiers)

Start:
 115,397,424 bp from pter      End:
 115,537,991 bp from pter
Size:
 140,568 bases      Orientation:
 plus strand

Proteins
for SYCP1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SYCP1_HUMAN, Q15431 (See protein sequence)
Recommended Name: Synaptonemal complex protein 1  
Size: 976 amino acids; 114192 Da
Subunit: Found in a complex with SYCE1 and SYCE2. Interacts with SYCE1 and SYCE2 (By similarity)
Subcellular location: Nucleus (By similarity). Chromosome (By similarity). Note=In tripartite segments of synaptonemal
complexes, between lateral elements in the nucleus. Found only where the chromosome cores are synapsed. Its N-terminus
is found towards the center of the synaptonemal complex while the C-terminus extends well into the lateral domain of
the synaptonemal complex (By similarity)
Secondary accessions: O14963 Q5VXJ6

Explore the universe of human proteins at neXtProt for SYCP1: NX_Q15431

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q15431

    • SYCP1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003167.2  
    ENSEMBL proteins: 
     ENSP00000358535   ENSP00000410011   ENSP00000358531  
    Reactome Protein details: Q15431
    Human Recombinant Protein Products: 
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    Novus Biologicals SYCP1 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SYCP1

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000795synaptonemal complex ----
    GO:0000801central element IEA--
    GO:0000802transverse filament IEA--
    GO:0001673male germ cell nucleus IEA--
    GO:0005634nucleus ----


    SYCP1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for SYCP1

    Protein Domains /
    Families
    for SYCP1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SYCP1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR008827 SCP-1

    Graphical View of Domain Structure for InterPro Entry Q15431

    ProtoNet protein and cluster: Q15431

    1 Blocks protein family: IPB008827 Synaptonemal complex 1

    UniProtKB/Swiss-Prot: SYCP1_HUMAN, Q15431
    Domain: Consists of an alpha-helical stretch of 700 AA residues, flanked by N- and C-terminal globular domains. The
    C-terminal domain has DNA-binding capacity (By similarity)


    Function
    for SYCP1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SYCP1_HUMAN, Q15431
    Function: Major component of the transverse filaments of synaptonemal complexes (SCS), formed between homologous
    chromosomes during meiotic prophase

         Genatlas biochemistry entry for SYCP1:
    synaptonemal complex protein 1,axial element,homolog to mouse Scp1,DNA binding protein involved in the structural
    organization of meiotic prophase chromosomes,

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SYCP1
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate SYCP1:
    hsa-miR-633 hsa-miR-186
    SwitchGear 3'UTR luciferase reporter plasmid: SYCP1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SYCP1 (see all 7)
    OriGene shRNA RFP: SYCP1
    OriGene siRNA: SYCP1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SYCP1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SYCP1

    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for SYCP1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYCP1

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005515protein binding ----


    SYCP1 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Sycp1tm1Aps for SYCP1
         2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Sycp1):
     endocrine/exocrine gland  reproductive system 

    SYCP1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SYCP1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Meiotic Synapsis
    		Meiotic Synapsis1.00
    		Chromosome Maintenance0.56
    		Meiosis0.70
    2Synapsis
    		Synapsis1.00
    3Cell Cycle
    		Cell Cycle1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5        Reactome Pathways for SYCP1
        Synapsis
    Meiotic Synapsis
    Cell Cycle
    Meiosis
    Chromosome Maintenance



    SYCP1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SYCP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    5/25 Interacting proteins for SYCP1 (Q154313 ENSP000003585314) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPK3P273613I2D: score=1 
    YWHABP319463I2D: score=1 
    HSPA2ENSP000002472074STRING: ENSP00000247207
    RAD21ENSP000002973384STRING: ENSP00000297338
    SMC1AENSP000003234214STRING: ENSP00000323421
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007130synaptonemal complex assembly ISS15944401
    GO:0007131reciprocal meiotic recombination TAS1464329
    GO:0007283spermatogenesis TAS1464329
    GO:0032880regulation of protein localization IEA--
    GO:0051301cell division IEA--


    SYCP1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SYCP1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SYCP1
    Search CenterWatch for drugs/clinical trials and news about SYCP1 

    Transcripts
    for SYCP1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SYCP1 gene: 
    NM_003176.2  

    Unigene Cluster for SYCP1:

    Synaptonemal complex protein 1
    Hs.112743  [show with all ESTs]
    Unigene Representative Sequence: NM_003176
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369522(uc001efr.3 uc010owt.2 uc001efq.3 uc009wgw.3)
    ENST00000455987 ENST00000369518 ENST00000477215 ENST00000468191 ENST00000482717
    ENST00000493377 ENST00000477590

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SYCP1
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate SYCP1:
    hsa-miR-633 hsa-miR-186
    SwitchGear 3'UTR luciferase reporter plasmid: SYCP1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SYCP1 (see all 7)
    OriGene shRNA RFP: SYCP1
    OriGene siRNA: SYCP1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SYCP1
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SYCP1
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    GenScript: all cDNA clones in your preferred vector: SYCP1 (NM_003176)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SYCP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYCP1 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SYCP1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SYCP1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SYCP1

    Additional cDNA sequence: 

    AF273043.1 AK315268.1 BC026162.2 BC065190.1 BC105299.1 BC126266.1 BC144019.1 BC144020.1 
    D67035.1 X95654.1 

    6 DOTS entries:

    DT.410796  DT.92456997  DT.92456998  DT.100742272  DT.410797  DT.121436631 

    24/129 AceView cDNA sequences (see all 129):

    NM_003176 BC026162 AA609655 AF273043 BG219427 BI462522 AA868393 BG214220 
    BG188770 BG772129 H64207 BG199574 BI561137 BG187175 BG185603 BG211521 
    BU569993 BG187176 BG202119 BI825601 BX105409 AA913875 BU854570 BG209504 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SYCP1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
    SP1:                                                                        
    SP2:                                                                        
    SP3:                                                        -               
    SP4:                                                                        


    ECgene alternative splicing isoforms for SYCP1

    Expression
    for SYCP1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SYCP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAAACTGTTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SYCP1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    TestisSeminiferous TubulesPrimary SpermatocyteGerm Cells, Male Gametocytes
    OvaryOvigerous CordXX Germ CellsFemale Gametocytes, Germ Cells
    OvaryOvigerous CordOvary
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SYCP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SYCP1

    SOURCE GeneReport for Unigene cluster: Hs.112743

    UniProtKB/Swiss-Prot: SYCP1_HUMAN, Q15431
    Tissue specificity: Testis

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    In Situ
    Assay Products:     
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    Orthologs
    for SYCP1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SYCP1 gene from 8/24 species (see all 24)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Sycp11 , 5 synaptonemal complex protein 11, 5 84.35(n)1
    75.03(a)1    		   3 (45.25 cM)5
    209571  NM_011516.21  NP_035646.21 
     1028184995 
    chicken
    (Gallus gallus)    		 Aves SYCP11 synaptonemal complex protein 1 59.68(n)
    46.47(a)    		   772081  XM_001235268.2  XP_001235269.2 
    lizard
    (Anolis carolinensis)    		 Reptilia SYCP16
    		 --
    		 14(a)
    		 1 ↔ 1
    		 4(130522741-130553135)
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.183952 Danio rerio, Similar to synaptonemal complex protein more 72.66(n)    BC045503.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta c(3)G6
    		 crossover suppressor on 3 of Gowen
    		 7(a)
    		 1 ↔ 1
    		 3R(11615195-11618335)
    worm
    (Caenorhabditis elegans)    		 Secernentea M151.46
    Y39G10AR.116
    		 Protein Y39G10AR.11
    		 9(a)
    8(a)
    		 possible ortholog
    possible ortholog
    		 II(3624201-3626953)
    I(2293134-2297314)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons MFP16
    		 MAR-binding filament-like protein 1
    		 5(a)
    		 1 ↔ 1
    		 3(5430889-5433817)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    		 MAR-binding filament-like protein 1, putative, exp...
    MAR-binding filament-like protein 1, putative, exp...
    		 8(a)
    8(a)
    		 possible ortholog
    possible ortholog
    		 5(4831822-4835626)
    1(4207553-4212302)


    ENSEMBL Gene Tree for SYCP1 (if available)
    TreeFam Gene Tree for SYCP1 (if available) 

    Paralogs
    for SYCP1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for SYCP1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1991 NCBI SNPs in SYCP1 are shown (see all 1991)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs2004233791,2
    		C--113256393(-) GCCCCC/GGNNNN 1 -- int10--------
    rs730005171,2
    		C,--115395515(+) GGTGGT/CACTTT 1 -- us2k12Minor allele frequency- C:0.16WA 120
    rs118044421,2
    		C,F,H,--115395583(+) AGACTC/TAGTTT 1 -- us2k12Minor allele frequency- T:0.05NA 124
    rs1838967821,2
    		--115395654(+) TTTATC/GGGGAA 1 -- us2k10--------
    rs1884362821,2
    		--115395665(+) TGATTA/GTTTCT 1 -- us2k10--------
    rs1478777231,2
    		--115395684(+) AAAATG/TAGCTA 1 -- us2k10--------
    rs1812468101,2
    		--115395910(+) TACTAA/CAAAGT 1 -- us2k10--------
    rs117997001,2
    		C,F,H,--115395974(+) TCTTCA/CCTCCA 1 -- us2k1 tfbs36Minor allele frequency- C:0.03NS NA 628
    rs1857812761,2
    		--115396123(+) AAATTC/TTTCAA 1 -- us2k10--------
    rs2008969261,2
    		--115396204(+) TCTCT-/CTTTTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SYCP1 (115397424 - 115537991 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 5 variations for SYCP1
         4 CNVs: 97475 2322 3306 64651
         1 Indel: 44435

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SYCP1
    DNA2.0 Custom Variant and Variant Library Synthesis for SYCP1

    Disorders / Diseases
    for SYCP1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SYCP1 for disorders           About GeneDecksing

    OMIM gene information: 602162    OMIM disorders: --

    15 diseases for SYCP1:    About MalaCards
    spermatocytoma    male infertility    testicular cancer    infertility
    azoospermia    cutaneous t cell lymphoma    squamous cell carcinoma    seminoma
    esophageal carcinoma    esophagitis    pancreatic carcinoma    carcinoma
    pancreatitis    adenocarcinoma    malaria

    1 disease from the University of Copenhagen DISEASES database for SYCP1:
    Spermatocytoma

    6 Novoseek disease relationships for SYCP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    testicular cancer 66.7 1 14991579 (1)
    infertility male 55.3 1 9436675 (1)
    azoospermia 47.3 1 16520322 (1)
    infertility 33.1 1 16520322 (1)
    tumors 4.74 3 9560255 (2), 16929165 (1)
    cancer 0 1 9560255 (1)

    Human Genome Epidemiology (HuGE) Navigator: SYCP1 (2 documents)

    Export disorders for SYCP1 gene to outside databases

    Publications
    for SYCP1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SYCP1 gene, integrated from 9 sources (see all 34):
    (articles sorted by number of sources associating them with SYCP1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a meiosis-specific protein as a member of the class of cancer/testis antigens. (PubMed id 9560255)1, 3, 9 Tureci O....Pfreundschuh M. (1998)
    2. Assignment of synaptonemal complex protein 1 (SCP1) to human chromosome 1p13 by fluorescence in situ hybridization and its expression in the testis. (PubMed id 9371398)1, 2, 9 Kondoh N.... Nishimune Y. (1997)
    3. Human synaptonemal complex protein 1 (SCP1): isolation and characterization of the cDNA and chromosomal localization of the gene. (PubMed id 9119375)1, 2, 9 Meuwissen R.L.J.... Heyting C. (1997)
    4. Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry. (PubMed id 17370265)1, 2 Denis N.J.... Figeys D. (2007)
    5. Two novel proteins recruited by synaptonemal complex protein 1 (SYCP1) are at the centre of meiosis. (PubMed id 15944401)1, 9 Costa Y....Cooke H.J. (2005)
    6. Identification of an epitope derived from the cancer testis antigen HOM-TES-14/SCP1 and presented by dendritic cells to circulating CD4+ T cells. (PubMed id 16030183)1, 9 Neumann F....Pfreundschuh M. (2005)
    7. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    8. Evaluation of 172 candidate polymorphisms for associa tion with oligozoospermia or azoospermia in a large cohort of men of European d escent. (PubMed id 20378615)1 Aston K.I....Carrell D.T. (2010)
    9. Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R....Peters J.M. (2010)
    10. Investigation of genetic susceptibility factors for h uman longevity - A targeted nonsynonymous SNP study. (PubMed id 20800603)1 Flachsbart F....Nebel A. (2010)

    External Searches for SYCP1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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    Genome Databases showing SYCP1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6847 HGNC: 11487 AceView: SYCP1 Ensembl:ENSG00000198765 euGenes: HUgn6847
    ECgene: SYCP1 H-InvDB: SYCP1

    Other Databases showing SYCP1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SYCP1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SYCP1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SYCP1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SYCP1 gene:
    Search GeneIP for patents involving SYCP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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