Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SYCP1 Gene

protein-coding   GIFtS: 56
GCID: GC01P115397

Synaptonemal Complex Protein 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Synaptonemal Complex Protein 11 2
Cancer/Testis Antigen 81 2 3
SCP12 3 5
CT82 3
SCP-12 3
HOM-TES-142

External Ids:    HGNC: 114871   Entrez Gene: 68472   Ensembl: ENSG000001987657   OMIM: 6021625   UniProtKB: Q154313   

Export aliases for SYCP1 gene to outside databases

Previous GC identifers: GC01P115810 GC01P114279 GC01P114497 GC01P114696 GC01P115109 GC01P115198 GC01P113255


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for SYCP1 Gene:
SYCP1 (synaptonemal complex protein 1) is a protein-coding gene. Diseases associated with SYCP1 include spermatocytoma, and testicular cancer.

UniProtKB/Swiss-Prot: SYCP1_HUMAN, Q15431
Function: Major component of the transverse filaments of synaptonemal complexes (SCS), formed between homologous
chromosomes during meiotic prophase

Gene Wiki entry for SYCP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000001.11  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SYCP1 gene promoter:
         COUP-TF1   AML1a   HTF   COUP   HNF-4alpha2   IRF-1   E4BP4   HNF-4alpha1   COUP-TF   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SYCP1 promoter sequence
   Search Chromatin IP Primers for SYCP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SYCP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13-p12   Ensembl cytogenetic band:  1p13.2   HGNC cytogenetic band: 1p13-p12

SYCP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SYCP1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P115397:  view genomic region     (about GC identifiers)

Start:
115,397,424 bp from pter      End:
115,537,991 bp from pter
Size:
140,568 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: SYCP1_HUMAN, Q15431 (See protein sequence)
Recommended Name: Synaptonemal complex protein 1  
Size: 976 amino acids; 114192 Da
Subunit: Found in a complex with SYCE1 and SYCE2. Interacts with SYCE1 and SYCE2 (By similarity)
Secondary accessions: O14963 Q5VXJ6

Explore the universe of human proteins at neXtProt for SYCP1: NX_Q15431

Explore proteomics data for SYCP1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys295
  • Modification sites at PhosphoSitePlus

  • See SYCP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001269470.1  NP_001269471.1  NP_003167.2  

    ENSEMBL proteins: 
     ENSP00000358535   ENSP00000410011   ENSP00000358531  
    Reactome Protein details: Q15431

    SYCP1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for SYCP1
    OriGene Protein Over-expression Lysate for SYCP1
    OriGene MassSpec for SYCP1
    OriGene Custom Protein Services for SYCP1
    GenScript Custom Purified and Recombinant Proteins Services for SYCP1
    Novus Biologicals SYCP1 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SYCP1

    SYCP1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for SYCP1
    OriGene Custom Antibody Services for SYCP1
    Novus Biologicals SYCP1 Antibodies
    Abcam antibodies for SYCP1
    Cloud-Clone Corp. Antibodies for SYCP1
    ThermoFisher Antibodies for SYCP1
    LSBio Antibodies in human, mouse, rat for SYCP1

    SYCP1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SYCP1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SYCP1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SYCP1
    Cloud-Clone Corp. CLIAs for SYCP1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR008827 SCP-1

    Graphical View of Domain Structure for InterPro Entry Q15431

    ProtoNet protein and cluster: Q15431

    1 Blocks protein domain: IPB008827 Synaptonemal complex 1

    UniProtKB/Swiss-Prot: SYCP1_HUMAN, Q15431
    Domain: Consists of an alpha-helical stretch of 700 AA residues, flanked by N- and C-terminal globular domains.
    The C-terminal domain has DNA-binding capacity (By similarity)


    SYCP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SYCP1_HUMAN, Q15431
    Function: Major component of the transverse filaments of synaptonemal complexes (SCS), formed between homologous
    chromosomes during meiotic prophase

         Genatlas biochemistry entry for SYCP1:
    synaptonemal complex protein 1,axial element,homolog to mouse Scp1,DNA binding protein involved in the structural
    organization of meiotic prophase chromosomes,

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005515protein binding ----
         
    SYCP1 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Sycp1):
     endocrine/exocrine gland  reproductive system 

    SYCP1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Sycp1tm1Aps for SYCP1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SYCP1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SYCP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SYCP1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SYCP1

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat SYCP1 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate SYCP1:
    hsa-miR-633 hsa-miR-186
    SwitchGear 3'UTR luciferase reporter plasmidSYCP1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SYCP1
    Predesigned siRNA for gene silencing in human, mouse, rat SYCP1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SYCP1

    Clone
    Products:
         
    OriGene clones in human, mouse for SYCP1 (see all 5)
    OriGene ORF clones in mouse, rat for SYCP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SYCP1 (NM_003176)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SYCP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYCP1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SYCP1
    Browse ESI BIO Cell Lines and PureStem Progenitors for SYCP1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYCP1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    SYCP1_HUMAN, Q15431: Nucleus (By similarity). Chromosome (By similarity). Note=In tripartite segments of
    synaptonemal complexes, between lateral elements in the nucleus. Found only where the chromosome cores are
    synapsed. Its N-terminus is found towards the center of the synaptonemal complex while the C-terminus extends
    well into the lateral domain of the synaptonemal complex (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol1
    golgi apparatus1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000795synaptonemal complex ----
    GO:0000801central element IEA--
    GO:0000802transverse filament IEA--
    GO:0001673male germ cell nucleus IEA--
    GO:0005694chromosome ----

    SYCP1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for SYCP1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Packaging Of Telomere Ends
    Meiotic Synapsis0.66
    Chromosome Maintenance0.62
    2Cell Cycle, Mitotic
    Cell Cycle0.90
    3Meiosis (REACTOME)
    Meiosis0.74

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for SYCP1
        Meiotic synapsis



    SYCP1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SYCP1
    Interactions:

        Search GeneGlobe Interaction Network for SYCP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

    Selected Interacting proteins for SYCP1 (Q154313 ENSP000003585314) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPK3P273613, ENSP000002630254I2D: score=1 STRING: ENSP00000263025
    YWHABP319463I2D: score=1 
    HSPA2ENSP000002472074STRING: ENSP00000247207
    RAD21ENSP000002973384STRING: ENSP00000297338
    SMC1AENSP000003234214STRING: ENSP00000323421
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007130synaptonemal complex assembly ISS15944401
    GO:0007131reciprocal meiotic recombination TAS1464329
    GO:0007283spermatogenesis TAS1464329
    GO:0032880regulation of protein localization IEA--
    GO:0051301cell division ----

    SYCP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SYCP1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for SYCP1 gene (3 alternative transcripts): 
    NM_001282541.1  NM_001282542.1  NM_003176.3  

    Unigene Cluster for SYCP1:

    Synaptonemal complex protein 1
    Hs.112743  [show with all ESTs]
    Unigene Representative Sequence: NM_003176
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369522(uc001efr.3 uc010owt.2 uc001efq.3 uc009wgw.3)
    ENST00000455987 ENST00000369518 ENST00000477215 ENST00000468191 ENST00000482717
    ENST00000493377 ENST00000477590
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SYCP1 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate SYCP1:
    hsa-miR-633 hsa-miR-186
    SwitchGear 3'UTR luciferase reporter plasmidSYCP1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SYCP1
    Predesigned siRNA for gene silencing in human, mouse, rat SYCP1
    Clone
    Products:
         
    OriGene clones in human, mouse for SYCP1 (see all 5)
    OriGene ORF clones in mouse, rat for SYCP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SYCP1 (NM_003176)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SYCP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYCP1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for SYCP1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SYCP1
      QuantiTect SYBR Green Assays in human, mouse, rat SYCP1
      QuantiFast Probe-based Assays in human, mouse, rat SYCP1

    Additional mRNA sequence: 

    AF273043.1 AK315268.1 BC026162.2 BC065190.1 BC105299.1 BC126266.1 BC144019.1 BC144020.1 
    D67035.1 X95654.1 

    6 DOTS entries:

    DT.410796  DT.92456997  DT.92456998  DT.100742272  DT.410797  DT.121436631 

    Selected AceView cDNA sequences (see all 129):

    AA609655 AF273043 NM_003176 BC026162 BG211017 BX105409 BU569048 BG197477 
    BG185603 BG184033 H64207 BG203186 AW182834 AI968160 BU853521 BG202654 
    BG191886 BG204698 AA926967 BG185089 BG213634 BG219426 BG201600 BG188770 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SYCP1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
    SP1:                                                                        
    SP2:                                                                        
    SP3:                                                        -               
    SP4:                                                                        


    ECgene alternative splicing isoforms for SYCP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    SYCP1 expression in normal human tissues (normalized intensities)      SYCP1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAACTGTTT
    SYCP1 Expression
    About this image


    SYCP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Gonad
             XY Germ Cells Testis Cord
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             XY Germ Cells Testis Cord
             sperm   
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             XX Germ Cells Ovigerous Cord
             Ovigerous Cord
    SYCP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SYCP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.112743

    UniProtKB/Swiss-Prot: SYCP1_HUMAN, Q15431
    Tissue specificity: Testis

        Custom PCR Arrays for SYCP1
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for SYCP1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SYCP1
    QuantiTect SYBR Green Assays in human, mouse, rat SYCP1
    QuantiFast Probe-based Assays in human, mouse, rat SYCP1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYCP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for SYCP1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sycp11 , 5 synaptonemal complex protein 11, 5 84.41(n)1
    74.95(a)1
      3 (45.25 cM)5
    209571  NM_011516.21  NP_035646.21 
     1028184995 
    chicken
    (Gallus gallus)
    Aves SYCP11 synaptonemal complex protein 1 64.93(n)
    53.24(a)
      772081  XM_004935006.1  XP_004935063.1 
    lizard
    (Anolis carolinensis)
    Reptilia SYCP16
    synaptonemal complex protein 1
    51(a)
    1 ↔ 1
    4(130522741-130553135)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia sycp11 synaptonemal complex protein 1 55.12(n)
    36.61(a)
      101734306  XM_004911387.1  XP_004911444.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.183952 Danio rerio, Similar to synaptonemal complex protein more 72.66(n)    BC045503.1 


    ENSEMBL Gene Tree for SYCP1 (if available)
    TreeFam Gene Tree for SYCP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for SYCP1 (see all 2441)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs730005171,2
    C,F--115395515(+) GGTGGT/CACTTT 1 -- us2k12Minor allele frequency- C:0.16WA 120
    rs118044421,2
    C,F,H--115395583(+) AGACTC/TAGTTT 1 -- us2k12Minor allele frequency- T:0.05NA 124
    rs1838967821,2
    --115395654(+) TTTATC/GGGGAA 1 -- us2k10--------
    rs1884362821,2
    C--115395665(+) TGATTA/GTTTCT 1 -- us2k10--------
    rs1478777231,2
    --115395684(+) AAAATG/TAGCTA 1 -- us2k10--------
    rs1812468101,2
    --115395910(+) TACTAA/CAAAGT 1 -- us2k10--------
    rs117997001,2
    C,F,H--115395974(+) TCTTCA/CCTCCA 1 -- us2k1 tfbs36Minor allele frequency- C:0.03NS NA 628
    rs1857812761,2
    --115396123(+) AAATTC/TTTCAA 1 -- us2k10--------
    rs2008969261,2
    --115396204(+) TCTCT-/CTTTTT 1 -- us2k10--------
    rs127357071,2
    C,F--115396226(+) ttttgG/Tgagac 1 -- us2k13Minor allele frequency- T:0.50NA 6

    HapMap Linkage Disequilibrium report for SYCP1 (115397424 - 115537991 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for SYCP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2610148CNV Deletion19546169
    esv2674805CNV Deletion23128226
    esv2347804CNV Deletion18987734
    esv28734CNV Loss19812545
    nsv872164CNV Loss21882294
    dgv333n71CNV Loss21882294
    nsv528883CNV Loss19592680
    nsv524392CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SYCP1
    DNA2.0 Custom Variant and Variant Library Synthesis for SYCP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 602162    OMIM disorders: --

    12 diseases for SYCP1:    About MalaCards
    spermatocytoma    testicular cancer    azoospermia    infertility
    seminoma    cutaneous t cell lymphoma    male infertility    nasopharyngitis
    esophagitis    squamous cell carcinoma    adenocarcinoma    pancreatitis


    SYCP1 for disorders           About GeneDecksing

    6 Novoseek inferred disease relationships for SYCP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    testicular cancer 66.7 1 14991579 (1)
    infertility male 55.3 1 9436675 (1)
    azoospermia 47.3 1 16520322 (1)
    infertility 33.1 1 16520322 (1)
    tumors 4.74 3 9560255 (2), 16929165 (1)
    cancer 0 1 9560255 (1)

    Genetic Association Database (GAD): SYCP1
    Human Genome Epidemiology (HuGE) Navigator: SYCP1 (2 documents)

    Export disorders for SYCP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for SYCP1 gene, integrated from 10 sources (see all 35):
    (articles sorted by number of sources associating them with SYCP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a meiosis-specific protein as a member of the class of cancer/testis antigens. (PubMed id 9560255)1, 3, 9 TA1reci O....Pfreundschuh M. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    2. Assignment of synaptonemal complex protein 1 (SCP1) to human chromosome 1p13 by fluorescence in situ hybridization and its expression in the testis. (PubMed id 9371398)1, 2, 9 Kondoh N.... Nishimune Y. (Cytogenet. Cell Genet. 1997)
    3. Human synaptonemal complex protein 1 (SCP1): isolation and characterization of the cDNA and chromosomal localization of the gene. (PubMed id 9119375)1, 2, 9 Meuwissen R.L.J.... Heyting C. (Genomics 1997)
    4. Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent. (PubMed id 20378615)1, 4 Aston K.I....Carrell D.T. (Hum. Reprod. 2010)
    5. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    6. Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry. (PubMed id 17370265)1, 2 Denis N.J.... Figeys D. (Proteomics 2007)
    7. Two novel proteins recruited by synaptonemal complex protein 1 (SYCP1) are at the centre of meiosis. (PubMed id 15944401)1, 9 Costa Y....Cooke H.J. (J. Cell. Sci. 2005)
    8. Identification of an epitope derived from the cancer testis antigen HOM-TES-14/SCP1 and presented by dendritic cells to circulating CD4+ T cells. (PubMed id 16030183)1, 9 Neumann F....Pfreundschuh M. (Blood 2005)
    9. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    10. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 6847 HGNC: 11487 AceView: SYCP1 Ensembl:ENSG00000198765 euGenes: HUgn6847
    ECgene: SYCP1 H-InvDB: SYCP1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SYCP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SYCP1 gene:
    Search GeneIP for patents involving SYCP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for SYCP1   OriGene RNAi products in human, mouse, rat for SYCP1  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for SYCP1  
     OriGene MassSpec something-or-other for SYCP1   OriGene clones in human, mouse for SYCP1  
     OriGene qSTAR qPCR primer pairs in human, mouse for SYCP1   OriGene Purified Protein for SYCP1  
     OriGene ORF clones in mouse, rat for SYCP1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SYCP1   OriGene Custom Protein Services for SYCP1  

     
     
     Block miRNA regulation of human, mouse, rat SYCP1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SYCP1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SYCP1 Predesigned siRNA for gene silencing in human, mouse, rat SYCP1
     QuantiFast Probe-based Assays in human, mouse, rat SYCP1 QuantiTect SYBR Green Assays in human, mouse, rat SYCP1
     Custom PCR Arrays for SYCP1 Search Chromatin IP Primers for SYCP1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SYCP1  Search GeneGlobe Interaction Network for SYCP1
     Regulatory tfbs in SYCP1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for SYCP1 GenScript cDNA clones with any tag delivered in your preferred vector for SYCP1
     GenScript Custom Assay Services for SYCP1 GenScript Custom overexpressing Cell Line Services for SYCP1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for SYCP1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SYCP1 antibodies
     SYCP1 proteins
     Antibodies for SYCP1
     See all of Abcam's Antibodies, Kits and Proteins for SYCP1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for SYCP1
     Antibodies for SYCP1
     ELISAs for SYCP1
     CLIAs for SYCP1



     Browse ESI BIO Cell Lines and PureStem Progenitors for SYCP1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYCP1
     SwitchGear 3'UTR luciferase reporter plasmids for SYCP1
     SwitchGear Promoter luciferase reporter plasmids for SYCP1
     ThermoFisher Antibodies for SYCP1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYCP1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SYCP1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SYCP1
     LSBio Antibodies in human, mouse, rat for SYCP1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SYCP1 gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4