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Aliases for SYCP1 Gene

Aliases for SYCP1 Gene

  • Synaptonemal Complex Protein 1 2 3
  • Cancer/Testis Antigen 8 2 3 4
  • SCP1 3 4 6
  • SCP-1 3 4
  • CT8 3 4
  • HOM-TES-14 3

External Ids for SYCP1 Gene

Previous GeneCards Identifiers for SYCP1 Gene

  • GC01P115810
  • GC01P114279
  • GC01P114497
  • GC01P114696
  • GC01P115109
  • GC01P115198
  • GC01P115397
  • GC01P113255

Summaries for SYCP1 Gene

GeneCards Summary for SYCP1 Gene

SYCP1 (Synaptonemal Complex Protein 1) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Meiosis.

UniProtKB/Swiss-Prot for SYCP1 Gene

  • Major component of the transverse filaments of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase

Gene Wiki entry for SYCP1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYCP1 Gene

Genomics for SYCP1 Gene

Regulatory Elements for SYCP1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SYCP1 Gene

114,854,803 bp from pter
114,995,370 bp from pter
140,568 bases
Plus strand

Genomic View for SYCP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SYCP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYCP1 Gene

Proteins for SYCP1 Gene

  • Protein details for SYCP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Synaptonemal complex protein 1
    Protein Accession:
    Secondary Accessions:
    • O14963
    • Q5VXJ6

    Protein attributes for SYCP1 Gene

    976 amino acids
    Molecular mass:
    114192 Da
    Quaternary structure:
    • Found in a complex with SYCE1 and SYCE2. Interacts with SYCE1 and SYCE2 (By similarity).

neXtProt entry for SYCP1 Gene

Proteomics data for SYCP1 Gene at MOPED

Post-translational modifications for SYCP1 Gene

  • Ubiquitination at Lys295
  • Modification sites at PhosphoSitePlus

Other Protein References for SYCP1 Gene

No data available for DME Specific Peptides for SYCP1 Gene

Domains for SYCP1 Gene

Protein Domains for SYCP1 Gene


Suggested Antigen Peptide Sequences for SYCP1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q15431
  • Consists of an alpha-helical stretch of 700 AA residues, flanked by N- and C-terminal globular domains. The C-terminal domain has DNA-binding capacity (By similarity).
genes like me logo Genes that share domains with SYCP1: view

No data available for Gene Families for SYCP1 Gene

Function for SYCP1 Gene

Molecular function for SYCP1 Gene

GENATLAS Biochemistry: synaptonemal complex protein 1,axial element,homolog to mouse Scp1,DNA binding protein involved in the structural organization of meiotic prophase chromosomes,
UniProtKB/Swiss-Prot Function: Major component of the transverse filaments of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase

Gene Ontology (GO) - Molecular Function for SYCP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with SYCP1: view

Phenotypes for SYCP1 Gene

genes like me logo Genes that share phenotypes with SYCP1: view

Animal Models for SYCP1 Gene

MGI Knock Outs for SYCP1:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for SYCP1 Gene

Localization for SYCP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYCP1 Gene

Nucleus. Chromosome. Note=In tripartite segments of synaptonemal complexes, between lateral elements in the nucleus. Found only where the chromosome cores are synapsed. Its N-terminus is found towards the center of the synaptonemal complex while the C-terminus extends well into the lateral domain of the synaptonemal complex (By similarity). {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for SYCP1 Gene COMPARTMENTS Subcellular localization image for SYCP1 gene
Compartment Confidence
nucleus 3
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SYCP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000795 synaptonemal complex --
GO:0000801 central element IEA --
GO:0000802 transverse filament IEA --
GO:0001673 male germ cell nucleus IEA --
GO:0005694 chromosome --
genes like me logo Genes that share ontologies with SYCP1: view

Pathways for SYCP1 Gene

genes like me logo Genes that share pathways with SYCP1: view

Pathways by source for SYCP1 Gene

4 Reactome pathways for SYCP1 Gene

Gene Ontology (GO) - Biological Process for SYCP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000711 meiotic DNA repair synthesis IEA --
GO:0007130 synaptonemal complex assembly ISS 15944401
GO:0007131 reciprocal meiotic recombination TAS 1464329
GO:0007283 spermatogenesis TAS 1464329
GO:0032880 regulation of protein localization IEA --
genes like me logo Genes that share ontologies with SYCP1: view

Transcripts for SYCP1 Gene

Unigene Clusters for SYCP1 Gene

Synaptonemal complex protein 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SYCP1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SYCP1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SYCP1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP3: -

Relevant External Links for SYCP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SYCP1 Gene

mRNA expression in normal human tissues for SYCP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SYCP1 Gene

This gene is overexpressed in Testis (51.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SYCP1 Gene

SOURCE GeneReport for Unigene cluster for SYCP1 Gene Hs.112743

mRNA Expression by UniProt/SwissProt for SYCP1 Gene

Tissue specificity: Testis
genes like me logo Genes that share expressions with SYCP1: view

In Situ Assay Products

Orthologs for SYCP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SYCP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SYCP1 35
  • 99.01 (n)
  • 98.35 (a)
SYCP1 36
  • 99 (a)
(Bos Taurus)
Mammalia SYCP1 35
  • 89.07 (n)
  • 83.5 (a)
SYCP1 36
  • 81 (a)
(Canis familiaris)
Mammalia SYCP1 35
  • 89.86 (n)
  • 84.63 (a)
SYCP1 36
  • 84 (a)
(Mus musculus)
Mammalia Sycp1 35
  • 84.41 (n)
  • 74.95 (a)
Sycp1 16
Sycp1 36
  • 73 (a)
(Monodelphis domestica)
Mammalia SYCP1 36
  • 65 (a)
(Ornithorhynchus anatinus)
Mammalia SYCP1 36
  • 52 (a)
(Rattus norvegicus)
Mammalia Sycp1 35
  • 84.18 (n)
  • 75.16 (a)
(Gallus gallus)
Aves SYCP1 35
  • 64.93 (n)
  • 53.24 (a)
SYCP1 36
  • 51 (a)
(Anolis carolinensis)
Reptilia SYCP1 36
  • 51 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sycp1 35
  • 55.12 (n)
  • 36.61 (a)
(Danio rerio)
Actinopterygii Dr.18395 35
sycp1 35
  • 48.72 (n)
  • 33.91 (a)
sycp1 36
  • 29 (a)
Species with no ortholog for SYCP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SYCP1 Gene

Gene Tree for SYCP1 (if available)
Gene Tree for SYCP1 (if available)

Paralogs for SYCP1 Gene

No data available for Paralogs for SYCP1 Gene

Variants for SYCP1 Gene

Sequence variations from dbSNP and Humsavar for SYCP1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs11084 -- 114,995,312(+) TGCTA(A/G)GAATG utr-variant-3-prime, nc-transcript-variant
rs360575 -- 114,915,587(+) CAAAG(A/C)CACTT intron-variant
rs360576 -- 114,916,553(+) TTTTA(G/T)TTTTT intron-variant
rs360577 -- 114,918,893(+) taggc(C/T)tttcc intron-variant
rs360578 -- 114,918,929(+) tacat(A/G)tttcc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SYCP1 Gene

Variant ID Type Subtype PubMed ID
esv28734 CNV Loss 19812545
nsv524392 CNV Gain 19592680
nsv528883 CNV Loss 19592680
esv2610148 CNV Deletion 19546169
esv2347804 CNV Deletion 18987734
esv2674805 CNV Deletion 23128226
dgv333n71 CNV Loss 21882294
nsv872164 CNV Loss 21882294

Relevant External Links for SYCP1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SYCP1 Gene

Disorders for SYCP1 Gene

(6) Novoseek inferred disease relationships for SYCP1 Gene

Disease -log(P) Hits PubMed IDs
testicular cancer 66.7 1
infertility male 55.3 1
azoospermia 47.3 1
infertility 33.1 1
tumors 4.74 3

Relevant External Links for SYCP1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with SYCP1: view

No data available for UniProtKB/Swiss-Prot for SYCP1 Gene

Publications for SYCP1 Gene

  1. Identification of a meiosis-specific protein as a member of the class of cancer/testis antigens. (PMID: 9560255) TA1reci O. … Pfreundschuh M. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3 23
  2. Human synaptonemal complex protein 1 (SCP1): isolation and characterization of the cDNA and chromosomal localization of the gene. (PMID: 9119375) Meuwissen R.L.J. … Heyting C. (Genomics 1997) 3 4 23
  3. Assignment of synaptonemal complex protein 1 (SCP1) to human chromosome 1p13 by fluorescence in situ hybridization and its expression in the testis. (PMID: 9371398) Kondoh N. … Nishimune Y. (Cytogenet. Cell Genet. 1997) 3 4 23
  4. Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry. (PMID: 17370265) Denis N.J. … Figeys D. (Proteomics 2007) 3 4
  5. Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent. (PMID: 20378615) Aston K.I. … Carrell D.T. (Hum. Reprod. 2010) 3 48

Products for SYCP1 Gene

Sources for SYCP1 Gene

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