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Aliases for SYCN Gene

Aliases for SYCN Gene

  • Syncollin 2 3
  • Insulin Synthesis-Associated Protein 1 3 4
  • Insulin Synthesis Associated 1 2 3
  • INSSA1 3 4
  • SYL 3 4

External Ids for SYCN Gene

Previous HGNC Symbols for SYCN Gene

  • INSSA1

Previous GeneCards Identifiers for SYCN Gene

  • GC19M044372
  • GC19M044385
  • GC19M039693
  • GC19M036140

Summaries for SYCN Gene

GeneCards Summary for SYCN Gene

SYCN (Syncollin) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SYCN Gene

  • Functions in exocytosis in pancreatic acinar cells regulating the fusion of zymogen granules with each other. May have a pore-forming activity on membranes and regulate exocytosis in other exocrine tissues (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYCN Gene

Genomics for SYCN Gene

Regulatory Elements for SYCN Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SYCN Gene

Start:
39,202,831 bp from pter
End:
39,204,266 bp from pter
Size:
1,436 bases
Orientation:
Minus strand

Genomic View for SYCN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SYCN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYCN Gene

Proteins for SYCN Gene

  • Protein details for SYCN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q0VAF6-SYCN_HUMAN
    Recommended name:
    Syncollin
    Protein Accession:
    Q0VAF6
    Secondary Accessions:

    Protein attributes for SYCN Gene

    Size:
    134 amino acids
    Molecular mass:
    14405 Da
    Quaternary structure:
    • Monomer and homooligomer; most probably hexameric. Interacts with GP2 (By similarity).

neXtProt entry for SYCN Gene

Proteomics data for SYCN Gene at MOPED

Post-translational modifications for SYCN Gene

Other Protein References for SYCN Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SYCN Gene

Domains for SYCN Gene

Protein Domains for SYCN Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SYCN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SYCN: view

No data available for Gene Families and UniProtKB/Swiss-Prot for SYCN Gene

Function for SYCN Gene

Molecular function for SYCN Gene

UniProtKB/Swiss-Prot Function: Functions in exocytosis in pancreatic acinar cells regulating the fusion of zymogen granules with each other. May have a pore-forming activity on membranes and regulate exocytosis in other exocrine tissues (By similarity).

Phenotypes for SYCN Gene

genes like me logo Genes that share phenotypes with SYCN: view

Animal Models for SYCN Gene

MGI Knock Outs for SYCN:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SYCN

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , miRNA , Transcription Factor Targeting and HOMER Transcription for SYCN Gene

Localization for SYCN Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYCN Gene

Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein; Lumenal side. Note=Localizes to zymogen granules. Associated with lipid rafts in a cholesterol-dependent manner. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SYCN Gene COMPARTMENTS Subcellular localization image for SYCN gene
Compartment Confidence
extracellular 3
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SYCN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030658 transport vesicle membrane IEA --
GO:0030667 secretory granule membrane IEA --
genes like me logo Genes that share ontologies with SYCN: view

Pathways for SYCN Gene

SuperPathways for SYCN Gene

No Data Available

Interacting Proteins for SYCN Gene

Selected Interacting proteins: Q0VAF6-SYCN_HUMAN for SYCN Gene via I2D

Symbol External ID(s) Details
STX1B

Gene Ontology (GO) - Biological Process for SYCN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006887 exocytosis IEA --
genes like me logo Genes that share ontologies with SYCN: view

No data available for Pathways by source for SYCN Gene

Compounds for SYCN Gene

(4) Novoseek inferred chemical compound relationships for SYCN Gene

Compound -log(P) Hits PubMed IDs
sucrose 31 2
calcium 10.3 2
cholesterol 7.32 5
lipid 0.177 4
genes like me logo Genes that share compounds with SYCN: view

Transcripts for SYCN Gene

mRNA/cDNA for SYCN Gene

(41) Selected AceView cDNA sequences:
(4) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SYCN Gene

Syncollin:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SYCN

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SYCN

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SYCN Gene

No ASD Table

Relevant External Links for SYCN Gene

GeneLoc Exon Structure for
SYCN
ECgene alternative splicing isoforms for
SYCN

Expression for SYCN Gene

mRNA expression in normal human tissues for SYCN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SYCN Gene

This gene is overexpressed in Pancreas (52.8).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SYCN Gene

SOURCE GeneReport for Unigene cluster for SYCN Gene Hs.124123

genes like me logo Genes that share expressions with SYCN: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for SYCN Gene

Orthologs for SYCN Gene

This gene was present in the common ancestor of chordates.

Orthologs for SYCN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SYCN 35
  • 98.76 (n)
  • 98.51 (a)
SYCN 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SYCN 35
  • 84.18 (n)
  • 77.12 (a)
SYCN 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SYCN 35
  • 84.46 (n)
  • 79.7 (a)
SYCN 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sycn 35
  • 75.94 (n)
  • 73.68 (a)
Sycn 16
Sycn 36
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sycn 35
  • 76.69 (n)
  • 72.18 (a)
chicken
(Gallus gallus)
Aves SYCN 35
  • 66.96 (n)
  • 57.14 (a)
lizard
(Anolis carolinensis)
Reptilia SYCN 36
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486753 35
  • 57.89 (n)
  • 51.75 (a)
zebrafish
(Danio rerio)
Actinopterygii CR450711.2 36
  • 42 (a)
OneToMany
SYCN (1 of 2) 36
  • 43 (a)
OneToMany
Species with no ortholog for SYCN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SYCN Gene

ENSEMBL:
Gene Tree for SYCN (if available)
TreeFam:
Gene Tree for SYCN (if available)

Paralogs for SYCN Gene

No data available for Paralogs for SYCN Gene

Variants for SYCN Gene

Sequence variations from dbSNP and Humsavar for SYCN Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs2082416 - 39,203,924(-) CGCGC(A/C)TGGAG missense, reference
rs3170352 -- 39,202,917(-) GGGCT(C/T)TGCTC downstream-variant-500B
rs3178415 -- 39,202,831(-) GTTGT(A/C)CCCGT downstream-variant-500B
rs35377096 -- 39,203,897(+) GTCTC(C/T)TAAGA missense, reference
rs56095034 -- 39,206,111(+) AAAAA(-/A)GAGAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SYCN Gene

Variant ID Type Subtype PubMed ID
nsv833829 CNV Loss 17160897

Relevant External Links for SYCN Gene

HapMap Linkage Disequilibrium report
SYCN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SYCN Gene

Disorders for SYCN Gene

(1) University of Copenhagen DISEASES for SYCN Gene

Relevant External Links for SYCN

Genetic Association Database (GAD)
SYCN
genes like me logo Genes that share disorders with SYCN: view

No data available for UniProtKB/Swiss-Prot for SYCN Gene

Publications for SYCN Gene

  1. Loss of the zymogen granule protein syncollin affects pancreatic protein synthesis and transport but not secretion. (PMID: 11839820) Antonin W. … Jahn R. (Mol. Cell. Biol. 2002) 2 3
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  3. Validation of four candidate pancreatic cancer serological biomarkers that improve the performance of CA19.9. (PMID: 24007603) Makawita S. … Diamandis E.P. (BMC Cancer 2013) 3
  4. Interleukin 28B polymorphisms are the only common genetic variants associated with low-density lipoprotein cholesterol (LDL-C) in genotype-1 chronic hepatitis C and determine the association between LDL-C and treatment response. (PMID: 22497812) Clark P.J. … Muir A.J. (J. Viral Hepat. 2012) 48
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for SYCN Gene

Sources for SYCN Gene

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