Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SYCN Gene

protein-coding GIFtS: 41
GCID: GC19M039693

syncollin

(Previous name: insulin synthesis associated 1 )
(Previous symbol: INSSA1)

Explore 4 diseases affiliated with
SYCN via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Syncollin¹
INSSA1¹ ² ³
SYL¹ ² ³
Insulin Synthesis Associated 1¹ ²
Insulin Synthesis-Associated Protein 1² ³
FLJ27441¹

External Ids:	HGNC: 18442¹	Entrez Gene: 342898²	Ensembl: ENSG00000179751⁷	UniProtKB: Q0VAF6³

Export aliases for SYCN gene to outside databases

Previous GC identifers: GC19M044372 GC19M044385 GC19M036140

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: SYCN_HUMAN, Q0VAF6

Function: Functions in exocytosis in pancreatic acinar cells regulating the fusion of zymogen granules with each other.

May have a pore-forming activity on membranes and regulate exocytosis in other exocrine tissues (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011109.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SYCN gene promoter:
CREB AML1a deltaCREB NRSF form 1 MyoD NRSF form 2 GATA-1 c-Ets-1
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for SYCN

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SYCN

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2 Ensembl cytogenetic band: 19q13.2 HGNC cytogenetic band: 19q13.2

SYCN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SYCN gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M039693: view genomic region (about GC identifiers)

Start:	39,693,562 bp from pter	End:	39,694,906 bp from pter
Size:	1,345 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SYCN_HUMAN, Q0VAF6 (See protein sequence)

Recommended Name: Syncollin precursor

Size: 134 amino acids; 14405 Da

Subunit: Monomer and homooligomer; most probably hexameric. Interacts with GP2 (By similarity)

Subcellular location: Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein; Lumenal side (By

similarity). Note=Localizes to zymogen granules (By similarity). Associated with lipid rafts in a

cholesterol-dependent manner (By similarity)

Explore the universe of human proteins at neXtProt for SYCN: NX_Q0VAF6

Post-translational modifications:

Contains intrachain disulfide bonds (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q0VAF6

SYCN Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001073937.1

ENSEMBL proteins:

ENSP00000325564

Human Recombinant Protein Products for SYCN:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: SYCN OriGene Custom Protein Services for SYCN
	GenScript Custom Purified and Recombinant Proteins Services for SYCN
	Novus Biologicals SYCN Protein Novus Biologicals SYCN Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SYCN

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0030658	transport vesicle membrane	IEA	--
GO:0030667	secretory granule membrane	IEA	--

SYCN for ontologies About GeneDecksing

SYCN Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for SYCN
	GenScript Custom Superior Antibodies Services for SYCN
	Novus Biologicals SYCN Antibodies
	Abcam antibodies for SYCN
	Uscn Antibodies for SYCN
	ThermoFisher Antibodies for SYCN

Assay Products for SYCN:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for SYCN
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for SYCN

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q0VAF6

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: SYCN_HUMAN, Q0VAF6

Function: Functions in exocytosis in pancreatic acinar cells regulating the fusion of zymogen granules with each other.

May have a pore-forming activity on membranes and regulate exocytosis in other exocrine tissues (By similarity)

Phenotypes:
1 GenomeRNAi human phenotype for SYCN:

Decreased viability with pacli

2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Sycn):

endocrine/exocrine gland

immune system

SYCN for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Sycn^tm1Rja for SYCN

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SYCN

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SYCN
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate SYCN:
		hsa-miR-3184 hsa-miR-423-5p
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SYCN (see all 7) OriGene shRNA RFP: SYCN OriGene siRNA: SYCN
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SYCN
		Sirion Biotech Custom design and validation of potent shRNA sequences against SYCN

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for SYCN
			Sirion Biotech Customized adenovirus for overexpression of SYCN Sirion Biotech Customized adenovirus for potent knockdown of SYCN

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SYCN (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SYCN OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SYCN (NM_001080468)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SYCN
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYCN

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SYCN
		Search LifeMap BioReagents cell lines for SYCN
		Sirion Biotech Customized stable knockdown cell line services for SYCN Sirion Biotech Customized inducible knockdown cell line services for SYCN Sirion Biotech Customized stable overexpressing cell line services for SYCN Sirion Biotech Customized inducible overexpressing cell line services for SYCN

In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for SYCN

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SYCN

1 Interacting protein for SYCN (Q0VAF6³) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
STX1B	P61266³	I2D: score=1

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006887	exocytosis	IEA	--

SYCN for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

SYCN for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SYCN
4 Novoseek chemical compound relationships for SYCN gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
sucrose	31	2	12235484 (1), 10753942 (1)
calcium	10.3	2	9244306 (2)
cholesterol	7.32	5	11389693 (4), 11853552 (1)
lipid	0.177	4	12235484 (2), 11853552 (2)

Search CenterWatch for drugs/clinical trials and news about SYCN

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SYCN gene:

NM_001080468.2

Unigene Cluster for SYCN:

Syncollin

Hs.124123 [show with all ESTs]

Unigene Representative Sequence: CA775865

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000318438(uc002okr.2)

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SYCN
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate SYCN:
		hsa-miR-3184 hsa-miR-423-5p
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SYCN (see all 7) OriGene shRNA RFP: SYCN OriGene siRNA: SYCN
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SYCN
		Sirion Biotech Custom design and validation of potent shRNA sequences against SYCN

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SYCN (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SYCN OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SYCN (NM_001080468)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SYCN
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYCN

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SYCN Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SYCN
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SYCN
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SYCN

Additional cDNA sequence:

AK130951.1 BC039541.1 BC121075.2 BC121076.2

3 DOTS entries:

DT.97838769 DT.95069317 DT.99998039

24/41 AceView cDNA sequences (see all 41):

BC039541 AA845110 BU579945 BX088921 AK130951 BM919811 AW600300 AW004051

BI832482 CA776833 BM509454 BI835878 BE045769 CA777117 BU069542 AA824393

BM509208 BQ267466 BM091222 BI837764 AI200988 BI837815 AA812593 BI835127

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SYCN expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCCCCGCTGC

About this image

SYCN expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Pancreas

Islets of Langerhans

Mature Beta Cells

Pancreas

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SYCN Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SYCN

SOURCE GeneReport for Unigene cluster: Hs.124123

SABiosciences Custom PCR Arrays for SYCN

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SYCN Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SYCN
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SYCN
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SYCN

In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for SYCN

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for SYCN gene from 4/8 species (see all 8) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Sycn^{1 , 5}	syncollin^{1, 5}	75.94(n)¹ 73.68(a)¹		7 (16.83 cM)⁵ 68416¹ NM_026716.3¹ NP_080992.3¹ 28540885⁵
chicken (Gallus gallus)	Aves	LOC100858140¹	syncollin-like	66.96(n) 57.14(a)		100858140 XM_003643498.1 XP_003643546.1
lizard (Anolis carolinensis)	Reptilia	SYCN⁶	--	53(a)	1 ↔ 1	GL343755.1(117121-117519)
zebrafish (Danio rerio)	Actinopterygii	LOC795071¹	syncollin-like	55.2(n) 44(a)		795071 XM_001335131.3 XP_001335167.1

ENSEMBL Gene Tree for SYCN (if available)
TreeFam Gene Tree for SYCN (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs193060228^1,2		--	39693179(+)	`CCAAAG/TTGCTA`	1	--	ds500¹		0	--	--	--	--
rs183570080^1,2		--	39693195(+)	`ACAGGC/TCTGAG`	1	--	ds500¹		0	--	--	--	--
rs77686449^1,2		--	39693313(+)	`TGGGCG/ATGTGT`	1	--	ds500¹		1		NA	120
rs187119516^1,2		--	39693470(+)	`GACGGC/GGACAA`	1	--	ds500¹		0	--	--	--	--
rs191932264^1,2		--	39693488(+)	`AAGGCC/TGTATT`	1	--	ds500¹		0	--	--	--	--
rs73553708^1,2	C,F	--	39693670(+)	`GGGCTC/GTCAGA`	1	--	int¹		5		WA CSA	126
rs140851376^1,2		--	39693848(+)	`GTCACC/TGCTGG`	1	--	int¹		0	--	--	--	--
rs112633711^1,2		--	39693931(+)	`GGGACG/TGATTT`	1	--	int¹		1		CSA	2
rs188319116^1,2		--	39693979(+)	`AGAGCA/GTGAAG`	1	--	int¹		0	--	--	--	--
rs116074489^1,2	C,F	--	39694284(+)	`GGGACC/TGGGTG`	1	--	int¹		1		WA	118

HapMap Linkage Disequilibrium report for SYCN (39693562 - 39694906 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SYCN: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SYCN

DNA2.0 Custom Variant and Variant Library Synthesis for SYCN

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SYCN for disorders About GeneDecksing

4 diseases for SYCN: About MalaCards

optic papillitis toxic encephalopathy cholesterol pancreatitis

1 disease from the University of Copenhagen DISEASES database for SYCN:

Toxic encephalopathy

Export disorders for SYCN gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SYCN gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with SYCN)

Utopia: connect your pdf to the dynamic
world of online information

Loss of the zymogen granule protein syncollin affects pancreatic protein synthesis and transport but not secretion. (PubMed id 11839820)^{1, 3} Antonin W....Jahn R. (2002)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Analysis of the association of syncollin with the membrane of the pancreatic zymogen granule. (PubMed id 10753942)⁹ An S.J....Edwardson J.M. (2000)
Cholesterol-dependent interaction of syncollin with the membrane of the pancreatic zymogen granule. (PubMed id 11389693)⁹ Hodel A....Edwardson J.M. (2001)
Syncollin homo-oligomers associate with lipid bilayers in the form of doughnut-shaped structures. (PubMed id 12235484)⁹ Geisse N.A....Edwardson J.M. (2002)
Ectopic expression of syncollin in INS-1 beta-cells sorts it into granules and impairs regulated secretion. (PubMed id 15766266)⁹ Li J....Li G. (2005)
Interaction of syncollin with GP-2, the major membrane protein of pancreatic zymogen granules, and association with lipid microdomains. (PubMed id 11853552)⁹ Kalus I....Schrader M. (2002)
The secretory granule protein syncollin localizes to HL-60 cells and neutrophils. (PubMed id 16517980)⁹ Bach J.P....Schrader M. (2006)
The secretory granule protein syncollin binds to syntaxin in a Ca2(+)-sensitive manner. (PubMed id 9244306)⁹ Edwardson J.M....Jahn R. (1997)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 342898	HGNC: 18442	AceView: SYCN	Ensembl:ENSG00000179751	euGenes: HUgn342898
ECgene: SYCN	H-InvDB: SYCN

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SYCN	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SYCN gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SYCN gene:
Search GeneIP for patents involving SYCN

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for SYCN
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SYCN		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SYCN
	OriGene Protein Over-expression Lysate for SYCN		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for SYCN		Browse 3'-UTR reporter clones for miRNA target validation
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SYCN		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SYCN
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for SYCN		OriGene Custom Protein Services for SYCN
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SYCN
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SYCN
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SYCN
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SYCN
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SYCN
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SYCN

	GenScript Custom Purified and Recombinant Proteins Services for SYCN		GenScript cDNA clones with any tag delivered in your preferred vector for SYCN
	GenScript Custom Assay Services for SYCN		GenScript Custom Superior Antibodies Services for SYCN
	GenScript Custom overexpressing Cell Line Services for SYCN		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in SYCN promoter
	Search Chromatin IP Primers for SYCN
	RT² qPCR Primer Assay in human, mouse, rat SYCN
	Search GNC Networks for SYCN
	SABiosciences Custom PCR Arrays for SYCN

Search Tocris compounds for SYCN

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	SYCN antibodies
	SYCN proteins
	SYCN lysates

	Antibodies for SYCN
	See all of Abcam's Antibodies, Kits and Proteins for SYCN
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

SYCN Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for SYCN

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for SYCN

	Browse SwitchGear 3'UTR luciferase reporter plasmids for SYCN
	Browse SwitchGear Promoter luciferase reporter plasmids for SYCN

ThermoFisher Antibodies for SYCN

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYCN

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SYCN

Sirion Biotech Customized:

	stable knockdown cell line services for SYCN
	inducible knockdown cell line services for SYCN
	design and validation of potent shRNA sequences against SYCN
	adenovirus for potent knockdown of SYCN
	adenovirus for overexpression of SYCN
	stable overexpressing cell line services for SYCN
	inducible overexpressing cell line services for SYCN

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes SYCN gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

SYCN Gene

syncollin

Aliases
for SYCN gene

Summaries
for SYCN gene

Genomic Views
for SYCN gene

Proteins
for SYCN gene

Protein Domains /
Families
for SYCN gene

Function
for SYCN gene

Pathways & Interactions
for SYCN gene

Drugs & Compounds
for SYCN gene

Transcripts
for SYCN gene

Expression
for SYCN gene

Orthologs
for SYCN gene

Paralogs
for SYCN gene

Genomic Variants
for SYCN gene

Disorders / Diseases
for SYCN gene

Publications
for SYCN gene

External Searches for SYCN gene

Genome Databases showing SYCN gene

Other Databases showing SYCN gene

Specialized Databases showing SYCN gene

Intellectual Property
for SYCN gene

Products
for SYCN gene

View Random Gene

Advanced Search

Export list of displayed genes

SYCN Gene

syncollin

Aliasesfor SYCN gene

Summariesfor SYCN gene

Genomic Viewsfor SYCN gene

Proteinsfor SYCN gene

Protein Domains /Familiesfor SYCN gene

Functionfor SYCN gene

Pathways & Interactionsfor SYCN gene

Drugs & Compoundsfor SYCN gene

Transcriptsfor SYCN gene

Expression for SYCN gene

Orthologsfor SYCN gene

Paralogsfor SYCN gene

Genomic Variantsfor SYCN gene

Disorders / Diseasesfor SYCN gene

Publicationsfor SYCN gene

External Searches for SYCN gene

Genome Databases showing SYCN gene

Other Databases showing SYCN gene

Specialized Databases showing SYCN gene

Intellectual Propertyfor SYCN gene

Productsfor SYCN gene

View Random Gene

Aliases
for SYCN gene

Summaries
for SYCN gene

Genomic Views
for SYCN gene

Proteins
for SYCN gene

Protein Domains /
Families
for SYCN gene

Function
for SYCN gene

Pathways & Interactions
for SYCN gene

Drugs & Compounds
for SYCN gene

Transcripts
for SYCN gene

Expression
for SYCN gene

Orthologs
for SYCN gene

Paralogs
for SYCN gene

Genomic Variants
for SYCN gene

Disorders / Diseases
for SYCN gene

Publications
for SYCN gene

Intellectual Property
for SYCN gene

Products
for SYCN gene