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Aliases for SYCN Gene

Aliases for SYCN Gene

  • Syncollin 2 3 3 5
  • Insulin Synthesis-Associated Protein 1 3 4
  • Insulin Synthesis Associated 1 2 3
  • INSSA1 3 4
  • SYL 3 4

External Ids for SYCN Gene

Previous HGNC Symbols for SYCN Gene

  • INSSA1

Previous GeneCards Identifiers for SYCN Gene

  • GC19M044372
  • GC19M044385
  • GC19M039693
  • GC19M036140

Summaries for SYCN Gene

GeneCards Summary for SYCN Gene

SYCN (Syncollin) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SYCN Gene

  • Functions in exocytosis in pancreatic acinar cells regulating the fusion of zymogen granules with each other. May have a pore-forming activity on membranes and regulate exocytosis in other exocrine tissues (By similarity).

Additional gene information for SYCN Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYCN Gene

Genomics for SYCN Gene

Regulatory Elements for SYCN Gene

Enhancers for SYCN Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H039166 1.4 Ensembl ENCODE dbSUPER 13.5 +36.1 36082 3 PKNOX1 NFIB SIN3A ZBTB7B ZNF121 GLIS2 SCRT2 EGR2 SP5 ZIK1 PAK4 HNRNPL FBL NCCRP1 SYCN ENSG00000269688 ZNF780B FBXO17 RPS16 ZNF780A
GH19H039204 1 ENCODE 0.7 -0.6 -648 1 TCF12 ZNF121 GTF3C2 ZNF766 GLIS2 KLF7 SP3 MEF2D SMARCA4 GLIS1 HNRNPL FBL ENSG00000269688 PAK4 RPS16 RN7SL566P ENSG00000268756 ACTN4 PSMC4 SYCN
GH19H039201 0.7 ENCODE 0.7 +2.3 2344 0 CTCF ZIC2 ZNF2 GLIS2 FOXK2 ZNF366 PATZ1 ZNF548 ZNF639 DPF2 HNRNPL PLEKHG2 FBL RN7SL566P ENSG00000269688 RPS16 NCCRP1 SYCN
GH19H039199 0.7 ENCODE 0.7 +4.5 4511 2 TFAP4 PKNOX1 ZNF362 ZNF521 CEBPG ZNF645 ZNF121 ZNF776 ZSCAN16 ZBTB33 ENSG00000266963 ENSG00000269172 ENSG00000269792 LOC105372399 LGALS14 ENSG00000267375 ENSG00000269445 CATSPERG LOC100129935 ZNF780B
GH19H039212 0.8 ENCODE 0.4 -8.3 -8290 0 RB1 ARNT NFXL1 RAD21 GTF3C2 ZNF391 ATF7 SMARCA5 ZNF654 ZNF280D HNRNPL FBL ENSG00000269688 PAK4 RN7SL566P ENSG00000268756 PSMC4 GC19M039650 PIR53704 SYCN
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SYCN on UCSC Golden Path with GeneCards custom track

Genomic Location for SYCN Gene

Chromosome:
19
Start:
39,202,831 bp from pter
End:
39,204,266 bp from pter
Size:
1,436 bases
Orientation:
Minus strand

Genomic View for SYCN Gene

Genes around SYCN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SYCN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SYCN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYCN Gene

Proteins for SYCN Gene

  • Protein details for SYCN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q0VAF6-SYCN_HUMAN
    Recommended name:
    Syncollin
    Protein Accession:
    Q0VAF6

    Protein attributes for SYCN Gene

    Size:
    134 amino acids
    Molecular mass:
    14405 Da
    Quaternary structure:
    • Monomer and homooligomer; most probably hexameric. Interacts with GP2 (By similarity).

neXtProt entry for SYCN Gene

Post-translational modifications for SYCN Gene

Other Protein References for SYCN Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SYCN Gene

Domains & Families for SYCN Gene

Gene Families for SYCN Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for SYCN Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SYCN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SYCN: view

No data available for UniProtKB/Swiss-Prot for SYCN Gene

Function for SYCN Gene

Molecular function for SYCN Gene

UniProtKB/Swiss-Prot Function:
Functions in exocytosis in pancreatic acinar cells regulating the fusion of zymogen granules with each other. May have a pore-forming activity on membranes and regulate exocytosis in other exocrine tissues (By similarity).
genes like me logo Genes that share phenotypes with SYCN: view

Animal Models for SYCN Gene

MGI Knock Outs for SYCN:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SYCN
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SYCN Gene

Localization for SYCN Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYCN Gene

Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein; Lumenal side. Note=Localizes to zymogen granules. Associated with lipid rafts in a cholesterol-dependent manner. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SYCN gene
Compartment Confidence
extracellular 3
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SYCN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0030658 transport vesicle membrane IEA --
GO:0030667 secretory granule membrane IEA --
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with SYCN: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SYCN Gene

Pathways & Interactions for SYCN Gene

No Data Available

Interacting Proteins for SYCN Gene

Selected Interacting proteins: Q0VAF6-SYCN_HUMAN for SYCN Gene via IID

Symbol External ID(s) Details
STX1B

Gene Ontology (GO) - Biological Process for SYCN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006887 exocytosis IEA --
genes like me logo Genes that share ontologies with SYCN: view

No data available for Pathways by source and SIGNOR curated interactions for SYCN Gene

Drugs & Compounds for SYCN Gene

(3) Drugs for SYCN Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for SYCN Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SYCN: view

Transcripts for SYCN Gene

mRNA/cDNA for SYCN Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(41) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SYCN Gene

Syncollin:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SYCN
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SYCN Gene

No ASD Table

Relevant External Links for SYCN Gene

GeneLoc Exon Structure for
SYCN
ECgene alternative splicing isoforms for
SYCN

Expression for SYCN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SYCN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SYCN Gene

This gene is overexpressed in Pancreas (x52.8).

Protein differential expression in normal tissues from HIPED for SYCN Gene

This gene is overexpressed in Pancreas (35.5), Pancreatic juice (25.7), and Islet of Langerhans (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SYCN Gene



Protein tissue co-expression partners for SYCN Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SYCN Gene:

SYCN

SOURCE GeneReport for Unigene cluster for SYCN Gene:

Hs.124123

Evidence on tissue expression from TISSUES for SYCN Gene

  • Pancreas(4)
genes like me logo Genes that share expression patterns with SYCN: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SYCN Gene

Orthologs for SYCN Gene

This gene was present in the common ancestor of chordates.

Orthologs for SYCN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SYCN 33 34
  • 98.76 (n)
dog
(Canis familiaris)
Mammalia SYCN 33 34
  • 84.46 (n)
cow
(Bos Taurus)
Mammalia SYCN 33 34
  • 84.18 (n)
rat
(Rattus norvegicus)
Mammalia Sycn 33
  • 76.69 (n)
mouse
(Mus musculus)
Mammalia Sycn 33 16 34
  • 75.94 (n)
chicken
(Gallus gallus)
Aves SYCN 33
  • 66.96 (n)
lizard
(Anolis carolinensis)
Reptilia SYCN 34
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486753 33
  • 57.89 (n)
zebrafish
(Danio rerio)
Actinopterygii SYCN (1 of 2) 34
  • 43 (a)
OneToMany
CR450711.2 34
  • 42 (a)
OneToMany
Species where no ortholog for SYCN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SYCN Gene

ENSEMBL:
Gene Tree for SYCN (if available)
TreeFam:
Gene Tree for SYCN (if available)

Paralogs for SYCN Gene

No data available for Paralogs for SYCN Gene

Variants for SYCN Gene

Sequence variations from dbSNP and Humsavar for SYCN Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000168233 -- 39,205,970(+) GGCAC(A/G)GTGAC upstream-variant-2KB
rs1000471317 -- 39,206,032(+) AGAGG(C/T)TGCAG upstream-variant-2KB
rs1001572415 -- 39,203,134(+) GCCTG(G/T)GAGTT intron-variant
rs1003338282 -- 39,203,816(+) GCTGG(G/T)GCCTG intron-variant
rs1003564331 -- 39,205,523(+) TGCAT(A/G)CAAAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SYCN Gene

Variant ID Type Subtype PubMed ID
nsv833829 CNV loss 17160897
nsv953571 CNV deletion 24416366

Variation tolerance for SYCN Gene

Residual Variation Intolerance Score: 74.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.52; 11.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SYCN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SYCN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SYCN Gene

Disorders for SYCN Gene

Relevant External Links for SYCN

Genetic Association Database (GAD)
SYCN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SYCN

No disorders were found for SYCN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SYCN Gene

Publications for SYCN Gene

  1. Loss of the zymogen granule protein syncollin affects pancreatic protein synthesis and transport but not secretion. (PMID: 11839820) Antonin W … Jahn R (Molecular and cellular biology 2002) 2 3 60
  2. Validation of four candidate pancreatic cancer serological biomarkers that improve the performance of CA19.9. (PMID: 24007603) Makawita S … Diamandis EP (BMC cancer 2013) 3 60
  3. Interleukin 28B polymorphisms are the only common genetic variants associated with low-density lipoprotein cholesterol (LDL-C) in genotype-1 chronic hepatitis C and determine the association between LDL-C and treatment response. (PMID: 22497812) Clark PJ … IDEAL investigators (Journal of viral hepatitis 2012) 45 60
  4. The secretory granule protein syncollin localizes to HL-60 cells and neutrophils. (PMID: 16517980) Bach JP … Schrader M (The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2006) 22 60
  5. Ectopic expression of syncollin in INS-1 beta-cells sorts it into granules and impairs regulated secretion. (PMID: 15766266) Li J … Li G (Biochemistry 2005) 22 60

Products for SYCN Gene

Sources for SYCN Gene

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