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Aliases for SYCE3 Gene

Aliases for SYCE3 Gene

  • Synaptonemal Complex Central Element Protein 3 2 3 5
  • Testis Highly Expressed Gene 2 Protein 3 4
  • Testis Highly Expressed Protein 2 2 3
  • C22orf41 3 4
  • THEG2 3 4
  • Chromosome 22 Open Reading Frame 41 2
  • THEG-2 4

External Ids for SYCE3 Gene

Previous HGNC Symbols for SYCE3 Gene

  • C22orf41

Previous GeneCards Identifiers for SYCE3 Gene

  • GC22M050990

Summaries for SYCE3 Gene

GeneCards Summary for SYCE3 Gene

SYCE3 (Synaptonemal Complex Central Element Protein 3) is a Protein Coding gene. Among its related pathways are Meiosis and Cell Cycle, Mitotic.

UniProtKB/Swiss-Prot for SYCE3 Gene

  • Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Required for chromosome loading of the central element-specific SCS proteins, and for initiating synapsis between homologous chromosomes. Chromosome loading appears to require SYCP1. Required for fertility.

Additional gene information for SYCE3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYCE3 Gene

Genomics for SYCE3 Gene

Regulatory Elements for SYCE3 Gene

Enhancers for SYCE3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22H050562 1 ENCODE 26.5 -0.3 -347 1 PKNOX1 ATF1 ARID4B SIN3A YY1 ZNF121 SLC30A9 GLIS2 ELK1 ZNF143 SYCE3 CHKB CPT1B LMF2 GC22P050566
GH22H050536 2.1 FANTOM5 Ensembl ENCODE dbSUPER 11.1 +19.2 19240 13 HDGF FOXA2 PKNOX1 ARNT ARID4B SIN3A YY1 SLC30A9 ZNF766 ZNF143 TYMP ODF3B ENSG00000272821 CPT1B SCO2 CHKB SYCE3 LOC105373098 ARSA TUBGCP6
GH22H050505 1.1 ENCODE 20.1 +55.1 55052 4 PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF207 ZNF143 SYCE3 LMF2 TYMP MIOX LOC105377205 BRD1 ARSA ENSG00000272940 NCAPH2
GH22H050152 0.5 FANTOM5 42.9 +410.4 410380 0 USF2 SYCE3 MOV10L1 MLC1 SELENOO CPT1B MIOX PANX2 ENSG00000280395
GH22H050619 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.9 -59.0 -58952 3 PKNOX1 ATF1 MLX ZFP64 SIN3A ARID4B DMAP1 YY1 ZNF121 GLIS2 ARSA CPT1B CHKB TUBGCP6 SYCE3 MAPK8IP2 HDAC10 NCAPH2 PPP6R2 SBF1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SYCE3 on UCSC Golden Path with GeneCards custom track

Promoters for SYCE3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000147743 -195 1001 PKNOX1 ATF1 ARID4B SIN3A YY1 SLC30A9 GLIS2 ELK1 ZNF143 KLF7

Genomic Location for SYCE3 Gene

Chromosome:
22
Start:
50,551,112 bp from pter
End:
50,562,905 bp from pter
Size:
11,794 bases
Orientation:
Minus strand

Genomic View for SYCE3 Gene

Genes around SYCE3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SYCE3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SYCE3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYCE3 Gene

Proteins for SYCE3 Gene

  • Protein details for SYCE3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A1L190-SYCE3_HUMAN
    Recommended name:
    Synaptonemal complex central element protein 3
    Protein Accession:
    A1L190

    Protein attributes for SYCE3 Gene

    Size:
    88 amino acids
    Molecular mass:
    10601 Da
    Quaternary structure:
    • Homodimer. Interacts with SYCE1. Interacts with SYCE2.

neXtProt entry for SYCE3 Gene

Post-translational modifications for SYCE3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SYCE3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SYCE3 Gene

Domains & Families for SYCE3 Gene

Gene Families for SYCE3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SYCE3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SYCE3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SYCE3: view

No data available for UniProtKB/Swiss-Prot for SYCE3 Gene

Function for SYCE3 Gene

Molecular function for SYCE3 Gene

UniProtKB/Swiss-Prot Function:
Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Required for chromosome loading of the central element-specific SCS proteins, and for initiating synapsis between homologous chromosomes. Chromosome loading appears to require SYCP1. Required for fertility.

Phenotypes From GWAS Catalog for SYCE3 Gene

Gene Ontology (GO) - Molecular Function for SYCE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SYCE3: view

Phenotypes for SYCE3 Gene

genes like me logo Genes that share phenotypes with SYCE3: view

Animal Models for SYCE3 Gene

MGI Knock Outs for SYCE3:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SYCE3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SYCE3 Gene

Localization for SYCE3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYCE3 Gene

Nucleus. Chromosome. Note=Colocalizes with SYCE1 in the central elements. {ECO:0000250 UniProtKB:B5KM66}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SYCE3 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SYCE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000801 central element ISS --
GO:0005634 nucleus ISS --
GO:0005694 chromosome ISS --
genes like me logo Genes that share ontologies with SYCE3: view

Pathways & Interactions for SYCE3 Gene

SuperPathways for SYCE3 Gene

SuperPathway Contained pathways
1 Meiosis
.73
2 Cell Cycle, Mitotic
genes like me logo Genes that share pathways with SYCE3: view

Pathways by source for SYCE3 Gene

3 Reactome pathways for SYCE3 Gene

Gene Ontology (GO) - Biological Process for SYCE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0007130 synaptonemal complex assembly ISS --
GO:0007131 reciprocal meiotic recombination ISS --
GO:0007283 spermatogenesis ISS --
GO:0043065 positive regulation of apoptotic process IEA --
genes like me logo Genes that share ontologies with SYCE3: view

No data available for SIGNOR curated interactions for SYCE3 Gene

Drugs & Compounds for SYCE3 Gene

No Compound Related Data Available

Transcripts for SYCE3 Gene

mRNA/cDNA for SYCE3 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SYCE3 Gene

Synaptonemal complex central element protein 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SYCE3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SYCE3 Gene

No ASD Table

Relevant External Links for SYCE3 Gene

GeneLoc Exon Structure for
SYCE3
ECgene alternative splicing isoforms for
SYCE3

Expression for SYCE3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SYCE3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SYCE3 Gene

This gene is overexpressed in Testis (x43.0).

NURSA nuclear receptor signaling pathways regulating expression of SYCE3 Gene:

SYCE3

SOURCE GeneReport for Unigene cluster for SYCE3 Gene:

Hs.535660
genes like me logo Genes that share expression patterns with SYCE3: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SYCE3 Gene

Orthologs for SYCE3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SYCE3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SYCE3 33 34
  • 99.62 (n)
dog
(Canis familiaris)
Mammalia SYCE3 33 34
  • 90.42 (n)
cow
(Bos Taurus)
Mammalia SYCE3 33 34
  • 89.92 (n)
mouse
(Mus musculus)
Mammalia Syce3 33 16 34
  • 86.97 (n)
rat
(Rattus norvegicus)
Mammalia Syce3 33
  • 85.44 (n)
chicken
(Gallus gallus)
Aves SYCE3 33
  • 73.33 (n)
lizard
(Anolis carolinensis)
Reptilia SYCE3 34
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia syce3 33
  • 66.27 (n)
zebrafish
(Danio rerio)
Actinopterygii SYCE3 34
  • 31 (a)
OneToOne
Species where no ortholog for SYCE3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SYCE3 Gene

ENSEMBL:
Gene Tree for SYCE3 (if available)
TreeFam:
Gene Tree for SYCE3 (if available)

Paralogs for SYCE3 Gene

No data available for Paralogs for SYCE3 Gene

Variants for SYCE3 Gene

Sequence variations from dbSNP and Humsavar for SYCE3 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1000018363 -- 50,561,473(+) CACCA(A/G)AGCAC intron-variant, upstream-variant-2KB
rs1000521753 -- 50,564,667(+) TTGAG(C/T)ACCCT intron-variant, upstream-variant-2KB
rs1000559790 -- 50,557,128(+) CATCT(C/T)CTCGA intron-variant
rs1000775439 -- 50,550,655(+) CCCCC(A/G)ATCTC intron-variant, utr-variant-3-prime
rs1000909837 -- 50,556,835(+) GGAGT(A/G)AGTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SYCE3 Gene

Variant ID Type Subtype PubMed ID
dgv2483n106 CNV deletion 24896259
esv2758852 CNV loss 17122850
esv5697 CNV gain 19470904
nsv1057656 CNV gain 25217958
nsv1059234 CNV gain 25217958
nsv1060174 CNV loss 25217958
nsv1073192 CNV deletion 25765185
nsv1160782 CNV deletion 26073780
nsv471224 CNV loss 18288195
nsv589222 CNV gain 21841781
nsv589223 CNV loss 21841781
nsv829340 CNV gain 20364138
nsv834238 CNV loss 17160897
nsv834239 CNV loss 17160897
nsv955202 CNV deletion 24416366

Variation tolerance for SYCE3 Gene

Gene Damage Index Score: 2.26; 40.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SYCE3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SYCE3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SYCE3 Gene

Disorders for SYCE3 Gene

Relevant External Links for SYCE3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SYCE3

No disorders were found for SYCE3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SYCE3 Gene

Publications for SYCE3 Gene

  1. A novel mouse synaptonemal complex protein is essential for loading of central element proteins, recombination, and fertility. (PMID: 21637789) Schramm S … Benavente R (PLoS genetics 2011) 2 3 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 60
  5. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R … Iakoucheva LM (Nature communications 2014) 3 60

Products for SYCE3 Gene

Sources for SYCE3 Gene

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