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Aliases for SYCE3 Gene

Aliases for SYCE3 Gene

  • Synaptonemal Complex Central Element Protein 3 2 3 5
  • Testis Highly Expressed Gene 2 Protein 3 4
  • Testis Highly Expressed Protein 2 2 3
  • C22orf41 3 4
  • THEG2 3 4
  • Chromosome 22 Open Reading Frame 41 2
  • THEG-2 4

External Ids for SYCE3 Gene

Previous HGNC Symbols for SYCE3 Gene

  • C22orf41

Previous GeneCards Identifiers for SYCE3 Gene

  • GC22M050990

Summaries for SYCE3 Gene

GeneCards Summary for SYCE3 Gene

SYCE3 (Synaptonemal Complex Central Element Protein 3) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SYCE3 Gene

  • Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Required for chromosome loading of the central element-specific SCS proteins, and for initiating synapsis between homologous chromosomes. Chromosome loading appears to require SYCP1. Required for fertility.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYCE3 Gene

Genomics for SYCE3 Gene

Regulatory Elements for SYCE3 Gene

Enhancers for SYCE3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around SYCE3 on UCSC Golden Path with GeneCards custom track

Promoters for SYCE3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for SYCE3 Gene

Chromosome:
22
Start:
50,551,112 bp from pter
End:
50,562,905 bp from pter
Size:
11,794 bases
Orientation:
Minus strand

Genomic View for SYCE3 Gene

Genes around SYCE3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SYCE3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SYCE3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYCE3 Gene

Proteins for SYCE3 Gene

  • Protein details for SYCE3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A1L190-SYCE3_HUMAN
    Recommended name:
    Synaptonemal complex central element protein 3
    Protein Accession:
    A1L190

    Protein attributes for SYCE3 Gene

    Size:
    88 amino acids
    Molecular mass:
    10601 Da
    Quaternary structure:
    • Homodimer. Interacts with SYCE1. Interacts with SYCE2.

neXtProt entry for SYCE3 Gene

Post-translational modifications for SYCE3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SYCE3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SYCE3 Gene

Domains & Families for SYCE3 Gene

Protein Domains for SYCE3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SYCE3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SYCE3: view

No data available for Gene Families and UniProtKB/Swiss-Prot for SYCE3 Gene

Function for SYCE3 Gene

Molecular function for SYCE3 Gene

UniProtKB/Swiss-Prot Function:
Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Required for chromosome loading of the central element-specific SCS proteins, and for initiating synapsis between homologous chromosomes. Chromosome loading appears to require SYCP1. Required for fertility.

Gene Ontology (GO) - Molecular Function for SYCE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SYCE3: view

Phenotypes for SYCE3 Gene

genes like me logo Genes that share phenotypes with SYCE3: view

Animal Models for SYCE3 Gene

MGI Knock Outs for SYCE3:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SYCE3 Gene

Localization for SYCE3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYCE3 Gene

Nucleus. Chromosome. Note=Colocalizes with SYCE1 in the central elements. {ECO:0000250 UniProtKB:B5KM66}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SYCE3 Gene COMPARTMENTS Subcellular localization image for SYCE3 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for SYCE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000801 central element ISS --
GO:0005634 nucleus ISS --
GO:0005694 chromosome ISS --
genes like me logo Genes that share ontologies with SYCE3: view

Pathways & Interactions for SYCE3 Gene

SuperPathways for SYCE3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SYCE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007130 synaptonemal complex assembly ISS --
GO:0007131 reciprocal meiotic recombination ISS --
GO:0007283 spermatogenesis ISS --
GO:0043065 positive regulation of apoptotic process IEA --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with SYCE3: view

No data available for Pathways by source and SIGNOR curated interactions for SYCE3 Gene

Drugs & Compounds for SYCE3 Gene

No Compound Related Data Available

Transcripts for SYCE3 Gene

mRNA/cDNA for SYCE3 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SYCE3 Gene

Synaptonemal complex central element protein 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SYCE3 Gene

No ASD Table

Relevant External Links for SYCE3 Gene

GeneLoc Exon Structure for
SYCE3
ECgene alternative splicing isoforms for
SYCE3

Expression for SYCE3 Gene

mRNA expression in normal human tissues for SYCE3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SYCE3 Gene

This gene is overexpressed in Testis (x43.0).

NURSA nuclear receptor signaling pathways regulating expression of SYCE3 Gene:

SYCE3

SOURCE GeneReport for Unigene cluster for SYCE3 Gene:

Hs.535660
genes like me logo Genes that share expression patterns with SYCE3: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for SYCE3 Gene

Orthologs for SYCE3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SYCE3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SYCE3 34
  • 89.92 (n)
  • 89.53 (a)
SYCE3 35
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SYCE3 34
  • 90.42 (n)
  • 90.8 (a)
SYCE3 35
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Syce3 34
  • 86.97 (n)
  • 90.8 (a)
Syce3 16
Syce3 35
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SYCE3 34
  • 99.62 (n)
  • 100 (a)
SYCE3 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Syce3 34
  • 85.44 (n)
  • 89.66 (a)
chicken
(Gallus gallus)
Aves SYCE3 34
  • 73.33 (n)
  • 76.47 (a)
lizard
(Anolis carolinensis)
Reptilia SYCE3 35
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia syce3 34
  • 66.27 (n)
  • 63.1 (a)
zebrafish
(Danio rerio)
Actinopterygii SYCE3 35
  • 31 (a)
OneToOne
Species where no ortholog for SYCE3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SYCE3 Gene

ENSEMBL:
Gene Tree for SYCE3 (if available)
TreeFam:
Gene Tree for SYCE3 (if available)

Paralogs for SYCE3 Gene

No data available for Paralogs for SYCE3 Gene

Variants for SYCE3 Gene

Sequence variations from dbSNP and Humsavar for SYCE3 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
VAR_060126 -
rs28429837 -- 50,555,627(+) TCTCC(A/T)CAACC intron-variant
rs28549096 -- 50,557,562(+) CTACC(A/G)TAATG intron-variant
rs6009921 -- 50,552,776(+) aggtc(A/G)ggtct intron-variant
rs6009922 -- 50,555,862(+) catct(C/T)ggctc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SYCE3 Gene

Variant ID Type Subtype PubMed ID
dgv2483n106 CNV deletion 24896259
esv2758852 CNV loss 17122850
esv5697 CNV gain 19470904
nsv1057656 CNV gain 25217958
nsv1059234 CNV gain 25217958
nsv1060174 CNV loss 25217958
nsv1073192 CNV deletion 25765185
nsv1160782 CNV deletion 26073780
nsv471224 CNV loss 18288195
nsv589222 CNV gain 21841781
nsv589223 CNV loss 21841781
nsv829340 CNV gain 20364138
nsv834238 CNV loss 17160897
nsv834239 CNV loss 17160897
nsv955202 CNV deletion 24416366

Variation tolerance for SYCE3 Gene

Gene Damage Index Score: 2.26; 40.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SYCE3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SYCE3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SYCE3 Gene

Disorders for SYCE3 Gene

Relevant External Links for SYCE3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SYCE3

No disorders were found for SYCE3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SYCE3 Gene

Publications for SYCE3 Gene

  1. A novel mouse synaptonemal complex protein is essential for loading of central element proteins, recombination, and fertility. (PMID: 21637789) Schramm S. … Benavente R. (PLoS Genet. 2011) 2 3 65
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  3. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R. … Iakoucheva L.M. (Nat. Commun. 2014) 3 65
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 65
  5. [Cloning and expression of a novel mouse testis gene TSEG-2]. (PMID: 19323366) Wang Z.Y. … Jiang G.S. (Zhonghua Nan Ke Xue 2009) 3 65

Products for SYCE3 Gene

Sources for SYCE3 Gene

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