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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SYCE3 Gene

protein-coding   GIFtS: 35
GCID: GC22M050990

Synaptonemal Complex Central Element Protein 3

(Previous name: chromosome 22 open reading frame 41)
(Previous symbol: C22orf41)
  Search for SYCE3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Synaptonemal Complex Central Element Protein 31 2     THEG22 3
C22orf411 2 3     Chromosome 22 Open Reading Frame 411
Testis Highly Expressed Protein 21 2     THEG-23
Testis Highly Expressed Gene 2 Protein2 3     

External Ids:    HGNC: 352451   Entrez Gene: 6441862   Ensembl: ENSG000002174427   UniProtKB: A1L1903   

Export aliases for SYCE3 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SYCE3 Gene: 
SYCE3 (synaptonemal complex central element protein 3) is a protein-coding gene.

UniProtKB/Swiss-Prot: SYCE3_HUMAN, A1L190
Function: Major component of the transverse central element of synaptonemal complexes (SCS), formed between
homologous chromosomes during meiotic prophase. Required for chromosome loading of the central element-specific
SCS proteins, and for initiating synapsis between homologous chromosomes. Chromosome loading appears to require
SYCP1. Required for fertility (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.2  NT_011526.7  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for SYCE3
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
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Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SYCE3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.33   Ensembl cytogenetic band:  22q13.33   HGNC cytogenetic band: 22q13.33

SYCE3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SYCE3 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M050990:  view genomic region     (about GC identifiers)

Start:
50,989,541 bp from pter      End:
51,001,334 bp from pter
Size:
11,794 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SYCE3_HUMAN, A1L190 (See protein sequence)
Recommended Name: Synaptonemal complex central element protein 3  
Size: 88 amino acids; 10601 Da
Subunit: Interacts with SYCE1 and SYCE2 (By similarity)
Subcellular location: Nucleus (By similarity). Chromosome (By similarity). Note=Colocalizes with SYCE1 in the
central elements (By similarity)

Explore the universe of human proteins at neXtProt for SYCE3: NX_A1L190

Explore proteomics data for SYCE3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_A1L190

  • SYCE3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SYCE3 Protein Expression
    REFSEQ proteins: NP_001116697.1  
    ENSEMBL proteins: 
     ENSP00000385480   ENSP00000385122  

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    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000801central element ISS--
    GO:0005634nucleus ISS--
    GO:0005694chromosome ISS--

    SYCE3 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: A1L190


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SYCE3_HUMAN, A1L190
    Function: Major component of the transverse central element of synaptonemal complexes (SCS), formed between
    homologous chromosomes during meiotic prophase. Required for chromosome loading of the central element-specific
    SCS proteins, and for initiating synapsis between homologous chromosomes. Chromosome loading appears to require
    SYCP1. Required for fertility (By similarity)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    SYCE3 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Syce3):
     endocrine/exocrine gland  reproductive system 

    SYCE3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Syce3tm1Rben for SYCE3

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SYCE3 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SYCE3

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for SYCE3 (ENSP000003851224) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SYCE2ENSP000002936954STRING: ENSP00000293695
    SYCE1ENSP000003412824STRING: ENSP00000341282
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IEA--
    GO:0007130synaptonemal complex assembly ISS--
    GO:0007131reciprocal meiotic recombination ISS--
    GO:0007283spermatogenesis ISS--
    GO:0051301cell division IEA--

    SYCE3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SYCE3

    Search CenterWatch for drugs/clinical trials and news about SYCE3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SYCE3 gene: 
    NM_001123225.1  

    Unigene Cluster for SYCE3:

    Synaptonemal complex central element protein 3
    Hs.535660  [show with all ESTs]
    Unigene Representative Sequence: HY226834
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000406915(uc003bmj.4 uc010hbe.3) ENST00000402753
    miRNA
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    Inhib. RNA
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    Additional mRNA sequence: 

    BC127859.1 BC127860.1 EU082028.1 

    2 DOTS entries:

    DT.408460  DT.120664574 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SYCE3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATAGCTGTA
    SYCE3 Expression
    About this image


    See SYCE3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SYCE3

    SOURCE GeneReport for Unigene cluster: Hs.535660
        SABiosciences Custom PCR Arrays for SYCE3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYCE3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for SYCE3 gene from 4/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Syce31 , 5 synaptonemal complex central element protein 31, 5 86.97(n)1
    90.8(a)1
      15 (44.87 cM)5
    754591  NM_001162880.11  NP_001156352.11 
     893901745 
    chicken
    (Gallus gallus)
    Aves SYCE31 synaptonemal complex central element protein 3 75.31(n)
    79.01(a)
      769096  XM_001231856.2  XP_001231857.1 
    lizard
    (Anolis carolinensis)
    Reptilia SYCE36
    synaptonemal complex central element protein 3
    71(a)
    1 ↔ 1
    4(138998475-139009888)
    zebrafish
    (Danio rerio)
    Actinopterygii SYCE36
    synaptonemal complex central element protein 3
    31(a)
    1 ↔ 1
    14(35642420-35643512)


    ENSEMBL Gene Tree for SYCE3 (if available)
    TreeFam Gene Tree for SYCE3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/313 SNPs in SYCE3 are shown (see all 313)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0601264
    ----see VAR_0601262 L P mis40--------
    rs1488326431,2
    --50990018(+) CTACAA/GACATC 1 -- int10--------
    rs113307411,2
    C--50990071(+) ATACAC/-CAGAC 1 -- int11Minor allele frequency- -:0.50CSA 2
    rs114279651,2
    C--50990082(+) TGATG-/TTAAAA 1 -- int10--------
    rs604149101,2
    C,F--50990086(+) TGTAAA/GAAACT 1 -- int11Minor allele frequency- G:0.21WA 118
    rs1862498061,2
    --50990125(+) AGAATC/TAGAGC 1 -- int10--------
    rs1900810051,2
    --50990178(+) TGCAGA/GTGACC 1 -- int10--------
    rs738912801,2
    C,F--50990216(+) ACACTC/TAGGTA 1 -- int12Minor allele frequency- T:0.16WA 120
    rs65201481,2
    C,F,A,H--50990323(+) GCTTTC/TGTTGA 1 -- int112Minor allele frequency- T:0.12NA NS EA WA CSA 666
    rs1434265811,2
    --50990424(+) CAACTC/TGAAGG 1 -- int10--------

    HapMap Linkage Disequilibrium report for SYCE3 (50989541 - 51001334 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SYCE3: --
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing SYCE3
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SYCE3 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with SYCE3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel mouse synaptonemal complex protein is essenti al for loading of central element proteins, recombination, and fertility. (PubMed id 21637789)1, 3 Schramm S....Benavente R. (2011)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. [Cloning and expression of a novel mouse testis gene TSEG-2] (PubMed id 19323366)1 Wang Z.Y....Jiang G.S. (2009)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    5. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 644186 HGNC: 35245 Ensembl:ENSG00000217442 euGenes: HUgn644186 ECgene: SYCE3
    H-InvDB: SYCE3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SYCE3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SYCE3 gene:
    Search GeneIP for patents involving SYCE3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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