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Aliases for SYCE3 Gene

Aliases for SYCE3 Gene

  • Synaptonemal Complex Central Element Protein 3 2 3
  • Testis Highly Expressed Gene 2 Protein 3 4
  • Testis Highly Expressed Protein 2 2 3
  • C22orf41 3 4
  • THEG2 3 4
  • Chromosome 22 Open Reading Frame 41 2
  • THEG-2 4

External Ids for SYCE3 Gene

Previous Symbols for SYCE3 Gene

  • C22orf41

Summaries for SYCE3 Gene

GeneCards Summary for SYCE3 Gene

SYCE3 (Synaptonemal Complex Central Element Protein 3) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SYCE3 Gene

  • Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Required for chromosome loading of the central element-specific SCS proteins, and for initiating synapsis between homologous chromosomes. Chromosome loading appears to require SYCP1. Required for fertility (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYCE3 Gene

Genomics for SYCE3 Gene

Genomic Location for SYCE3 Gene

Start:
50,551,112 bp from pter
End:
50,562,905 bp from pter
Size:
11,794 bases
Orientation:
Minus strand

Genomic View for SYCE3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SYCE3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYCE3 Gene

No data available for Regulatory Elements for SYCE3 Gene

Proteins for SYCE3 Gene

  • Protein details for SYCE3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A1L190-SYCE3_HUMAN
    Recommended name:
    Synaptonemal complex central element protein 3
    Protein Accession:
    A1L190
    Secondary Accessions:

    Protein attributes for SYCE3 Gene

    Size:
    88 amino acids
    Molecular mass:
    10601 Da
    Quaternary structure:
    • Interacts with SYCE1 and SYCE2.

neXtProt entry for SYCE3 Gene

Proteomics data for SYCE3 Gene at MOPED

Post-translational modifications for SYCE3 Gene

No Post-translational modifications

Other Protein References for SYCE3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SYCE3 Gene

Domains for SYCE3 Gene

Protein Domains for SYCE3 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with SYCE3: view

No data available for Gene Families and UniProtKB/Swiss-Prot for SYCE3 Gene

Function for SYCE3 Gene

Molecular function for SYCE3 Gene

UniProtKB/Swiss-Prot Function: Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Required for chromosome loading of the central element-specific SCS proteins, and for initiating synapsis between homologous chromosomes. Chromosome loading appears to require SYCP1. Required for fertility (By similarity).

Gene Ontology (GO) - Molecular Function for SYCE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SYCE3: view

Phenotypes for SYCE3 Gene

genes like me logo Genes that share phenotypes with SYCE3: view

Animal Models for SYCE3 Gene

MGI Knock Outs for SYCE3:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for SYCE3 Gene

Localization for SYCE3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYCE3 Gene

Nucleus. Chromosome. Note=Colocalizes with SYCE1 in the central elements. {ECO:0000250}.

Gene Ontology (GO) - Cellular Components for SYCE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000801 central element ISS --
GO:0005634 nucleus ISS --
GO:0005694 chromosome ISS --
genes like me logo Genes that share ontologies with SYCE3: view

Pathways for SYCE3 Gene

SuperPathways for SYCE3 Gene

No Data Available

Interacting Proteins for SYCE3 Gene

Gene Ontology (GO) - Biological Process for SYCE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007130 synaptonemal complex assembly ISS --
GO:0007131 reciprocal meiotic recombination ISS --
GO:0007283 spermatogenesis ISS --
GO:0043065 positive regulation of apoptotic process IEA --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with SYCE3: view

No data available for Pathways by source for SYCE3 Gene

Transcripts for SYCE3 Gene

mRNA/cDNA for SYCE3 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SYCE3 Gene

Synaptonemal complex central element protein 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SYCE3 Gene

No ASD Table

Relevant External Links for SYCE3 Gene

GeneLoc Exon Structure for
SYCE3
ECgene alternative splicing isoforms for
SYCE3

Expression for SYCE3 Gene

mRNA expression in normal human tissues for SYCE3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SYCE3 Gene

This gene is overexpressed in Testis (43.0).

SOURCE GeneReport for Unigene cluster for SYCE3 Gene Hs.535660

genes like me logo Genes that share expressions with SYCE3: view

Orthologs for SYCE3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SYCE3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SYCE3 36
  • 99.62 (n)
  • 100 (a)
SYCE3 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SYCE3 36
  • 89.92 (n)
  • 89.53 (a)
SYCE3 37
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SYCE3 36
  • 90.42 (n)
  • 90.8 (a)
SYCE3 37
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Syce3 36
  • 86.97 (n)
  • 90.8 (a)
Syce3 16
Syce3 37
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Syce3 36
  • 85.44 (n)
  • 89.66 (a)
chicken
(Gallus gallus)
Aves SYCE3 36
  • 73.33 (n)
  • 76.47 (a)
lizard
(Anolis carolinensis)
Reptilia SYCE3 37
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia syce3 36
  • 66.27 (n)
  • 63.1 (a)
zebrafish
(Danio rerio)
Actinopterygii SYCE3 37
  • 31 (a)
OneToOne
Species with no ortholog for SYCE3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SYCE3 Gene

ENSEMBL:
Gene Tree for SYCE3 (if available)
TreeFam:
Gene Tree for SYCE3 (if available)

Paralogs for SYCE3 Gene

No data available for Paralogs for SYCE3 Gene

Variants for SYCE3 Gene

Sequence variations from dbSNP and Humsavar for SYCE3 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs131768 -- 50,563,409(-) GGGAG(A/G)CCCCA upstream-variant-2KB
rs131769 -- 50,562,965(-) CGGGG(A/C)GGGTT upstream-variant-2KB
rs131770 -- 50,558,252(-) GAGAC(G/T)GGGTT intron-variant
rs131771 -- 50,557,737(-) TTACA(-/ACA)TTATT intron-variant
rs131772 -- 50,556,074(-) ggctc(A/G)ctcct intron-variant

Relevant External Links for SYCE3 Gene

HapMap Linkage Disequilibrium report
SYCE3

No data available for Structural Variations from Database of Genomic Variants (DGV) for SYCE3 Gene

Disorders for SYCE3 Gene

No disorders were found for SYCE3 Gene.

No data available for UniProtKB/Swiss-Prot for SYCE3 Gene

Publications for SYCE3 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. A novel mouse synaptonemal complex protein is essential for loading of central element proteins, recombination, and fertility. (PMID: 21637789) Schramm S. … Benavente R. (PLoS Genet. 2011) 2 3
  3. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R. … Iakoucheva L.M. (Nat. Commun. 2014) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. [Cloning and expression of a novel mouse testis gene TSEG-2]. (PMID: 19323366) Wang Z.Y. … Jiang G.S. (Zhonghua Nan Ke Xue 2009) 3

Products for SYCE3 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate SYCE3
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for SYCE3
    • Block miRNA regulation of SYCE3 using miScript Target Protectors

    Sources for SYCE3 Gene

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