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Aliases for SYCE2 Gene

Aliases for SYCE2 Gene

  • Synaptonemal Complex Central Element Protein 2 2 3
  • CESC1 3 4 6
  • Central Element Synaptonemal Complex Protein 1 4
  • Central Element Synaptonemal Complex 1 2

External Ids for SYCE2 Gene

Previous GeneCards Identifiers for SYCE2 Gene

  • GC19M012872
  • GC19U900619
  • GC19M013010
  • GC19M012581

Summaries for SYCE2 Gene

Entrez Gene Summary for SYCE2 Gene

  • The protein encoded by this gene is part of the synaptonemal complex formed between homologous chromosomes during meiotic prophase. The encoded protein associates with SYCP1 and SYCE1 and is found only where chromosome cores are synapsed. [provided by RefSeq, Dec 2012]

GeneCards Summary for SYCE2 Gene

SYCE2 (Synaptonemal Complex Central Element Protein 2) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Meiosis.

UniProtKB/Swiss-Prot for SYCE2 Gene

  • Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Requires SYCP1 in order to be incorporated into the central element. May have a role in the synaptonemal complex assembly, stabilization and recombination (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYCE2 Gene

Genomics for SYCE2 Gene

Regulatory Elements for SYCE2 Gene

Transcription factor binding sites by QIAGEN in the SYCE2 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SYCE2 Gene

Start:
12,898,738 bp from pter
End:
12,919,302 bp from pter
Size:
20,565 bases
Orientation:
Minus strand

Genomic View for SYCE2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SYCE2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYCE2 Gene

Proteins for SYCE2 Gene

  • Protein details for SYCE2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PIF2-SYCE2_HUMAN
    Recommended name:
    Synaptonemal complex central element protein 2
    Protein Accession:
    Q6PIF2
    Secondary Accessions:
    • B4DYD3

    Protein attributes for SYCE2 Gene

    Size:
    218 amino acids
    Molecular mass:
    24690 Da
    Quaternary structure:
    • Homodimer. Found in a complex with SYCP1 and SYCE1. Interacts with SYCP1, SYCE1 and SYCE3 (By similarity).

neXtProt entry for SYCE2 Gene

Proteomics data for SYCE2 Gene at MOPED

Post-translational modifications for SYCE2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SYCE2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SYCE2 Gene

Domains for SYCE2 Gene

Protein Domains for SYCE2 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for SYCE2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6PIF2

UniProtKB/Swiss-Prot:

SYCE2_HUMAN :
  • Q6PIF2
Family:
  • Belongs to the SYCE family.
genes like me logo Genes that share domains with SYCE2: view

No data available for Gene Families for SYCE2 Gene

Function for SYCE2 Gene

Molecular function for SYCE2 Gene

UniProtKB/Swiss-Prot Function: Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Requires SYCP1 in order to be incorporated into the central element. May have a role in the synaptonemal complex assembly, stabilization and recombination (By similarity).

Gene Ontology (GO) - Molecular Function for SYCE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with SYCE2: view

Phenotypes for SYCE2 Gene

genes like me logo Genes that share phenotypes with SYCE2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SYCE2 Mrp2 - 6621

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SYCE2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SYCE2 Gene

Localization for SYCE2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYCE2 Gene

Nucleus. Note=Associates with chromatin. In prophase I stage of meiosis, localizes in the transverse central elements of the central region between lateral elements of the synaptonemal complexes. Found only where the chromosome cores are synapsed. Colocalizes with SYCE1 in the central elements (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SYCE2 Gene COMPARTMENTS Subcellular localization image for SYCE2 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for SYCE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000801 central element ISS --
genes like me logo Genes that share ontologies with SYCE2: view

Pathways for SYCE2 Gene

genes like me logo Genes that share pathways with SYCE2: view

Pathways by source for SYCE2 Gene

4 Reactome pathways for SYCE2 Gene

Interacting Proteins for SYCE2 Gene

Gene Ontology (GO) - Biological Process for SYCE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007130 synaptonemal complex assembly NAS 15944401
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with SYCE2: view

Transcripts for SYCE2 Gene

mRNA/cDNA for SYCE2 Gene

(18) Selected AceView cDNA sequences:
(4) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SYCE2 Gene

Synaptonemal complex central element protein 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SYCE2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SYCE2
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SYCE2 Gene

No ASD Table

Relevant External Links for SYCE2 Gene

GeneLoc Exon Structure for
SYCE2
ECgene alternative splicing isoforms for
SYCE2

Expression for SYCE2 Gene

mRNA expression in normal human tissues for SYCE2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SYCE2 Gene

This gene is overexpressed in Testis (13.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SYCE2 Gene

SOURCE GeneReport for Unigene cluster for SYCE2 Gene Hs.655173

genes like me logo Genes that share expressions with SYCE2: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for SYCE2 Gene

Orthologs for SYCE2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SYCE2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SYCE2 35
  • 99.69 (n)
  • 99.54 (a)
SYCE2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SYCE2 35
  • 85.86 (n)
  • 82.42 (a)
SYCE2 36
  • 71 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SYCE2 35
  • 86.46 (n)
  • 85.45 (a)
SYCE2 36
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Syce2 35
  • 78.34 (n)
  • 73.89 (a)
Syce2 16
Syce2 36
  • 67 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SYCE2 36
  • 39 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SYCE2 36
  • 28 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Syce2 35
  • 77.71 (n)
  • 73.89 (a)
chicken
(Gallus gallus)
Aves SYCE2 35
  • 64.24 (n)
  • 53.64 (a)
lizard
(Anolis carolinensis)
Reptilia SYCE2 36
  • 48 (a)
OneToOne
Species with no ortholog for SYCE2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SYCE2 Gene

ENSEMBL:
Gene Tree for SYCE2 (if available)
TreeFam:
Gene Tree for SYCE2 (if available)

Paralogs for SYCE2 Gene

Pseudogenes.org Pseudogenes for SYCE2 Gene

genes like me logo Genes that share paralogs with SYCE2: view

No data available for Paralogs for SYCE2 Gene

Variants for SYCE2 Gene

Sequence variations from dbSNP and Humsavar for SYCE2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs741702 -- 12,913,436(+) CACCG(A/C)GGGTG intron-variant
rs2003262 -- 12,912,157(+) ggtct(C/G)gaact intron-variant
rs2900660 -- 12,912,045(-) CAGGA(G/T)AATTG intron-variant
rs3115524 -- 12,910,545(+) ttttt(A/G)tattt intron-variant
rs4804743 -- 12,907,611(+) catgg(C/G/T)gaaac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SYCE2 Gene

Variant ID Type Subtype PubMed ID
nsv911082 CNV Loss 21882294
nsv833754 CNV Loss 17160897
esv2668234 CNV Deletion 23128226

Relevant External Links for SYCE2 Gene

HapMap Linkage Disequilibrium report
SYCE2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SYCE2 Gene

Disorders for SYCE2 Gene

Relevant External Links for SYCE2

Genetic Association Database (GAD)
SYCE2
Human Genome Epidemiology (HuGE) Navigator
SYCE2
genes like me logo Genes that share disorders with SYCE2: view

No data available for UniProtKB/Swiss-Prot for SYCE2 Gene

Publications for SYCE2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Two novel proteins recruited by synaptonemal complex protein 1 (SYCP1) are at the centre of meiosis. (PMID: 15944401) Costa Y. … Cooke H.J. (J. Cell. Sci. 2005) 2 3
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48

Products for SYCE2 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate SYCE2
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat
  • Predesigned siRNA for gene silencing in human,mouse,rat for SYCE2
  • Block miRNA regulation of SYCE2 using miScript Target Protectors

Sources for SYCE2 Gene

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