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Aliases for SYCE2 Gene

Aliases for SYCE2 Gene

  • Synaptonemal Complex Central Element Protein 2 2 3 5
  • CESC1 3 4
  • Central Element Synaptonemal Complex Protein 1 4
  • Central Element Synaptonemal Complex 1 2

External Ids for SYCE2 Gene

Previous GeneCards Identifiers for SYCE2 Gene

  • GC19M012872
  • GC19U900619
  • GC19M013010
  • GC19M012581

Summaries for SYCE2 Gene

Entrez Gene Summary for SYCE2 Gene

  • The protein encoded by this gene is part of the synaptonemal complex formed between homologous chromosomes during meiotic prophase. The encoded protein associates with SYCP1 and SYCE1 and is found only where chromosome cores are synapsed. [provided by RefSeq, Dec 2012]

GeneCards Summary for SYCE2 Gene

SYCE2 (Synaptonemal Complex Central Element Protein 2) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Meiosis.

UniProtKB/Swiss-Prot for SYCE2 Gene

  • Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Requires SYCP1 in order to be incorporated into the central element. May have a role in the synaptonemal complex assembly, stabilization and recombination (By similarity).

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYCE2 Gene

Genomics for SYCE2 Gene

Regulatory Elements for SYCE2 Gene

Enhancers for SYCE2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G012781 1.9 FANTOM5 ENCODE dbSUPER 10.5 +130.0 130046 16.0 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 ZNF136 ZNF844 CCDC130 ZNF564 ZNF442 ZNF625 MRI1 ZNF44 C19orf43 WDR83OS
GH19G013042 1.8 FANTOM5 ENCODE dbSUPER 11 -124.6 -124630 3.0 AGO1 YY1 ZNF143 ZNF416 ZNF263 SP3 TBX21 MEF2D ZFP41 GLIS1 TRMT1 ZNF136 CCDC130 ZNF564 ZNF791 ZNF788 ZNF442 ZNF44 WDR83OS ZNF709
GH19G013632 1.5 Ensembl ENCODE dbSUPER 10.5 -713.9 -713904 1.7 PKNOX1 ZFP64 ZNF133 FEZF1 ZNF48 GLIS2 KLF7 YY2 NFYC REST CCDC130 SNRPGP15 MRI1 RPS6P25 WDR83OS RTBDN SYCE2 MAST1 TRMT1 C19orf43
GH19G013044 1.2 dbSUPER 10.6 -121.3 -121262 1.8 HDGF FOXA2 PKNOX1 CREB3L1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 LYL1 NFIX TRMT1 NACC1 DAND5 GADD45GIP1 ZNF709 IER2 STX10 ZNF625
GH19G013055 1.2 dbSUPER 10.6 -120.9 -120930 1.8 CREB3L1 MLX DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC GLIS1 LYL1 NFIX TRMT1 NACC1 DAND5 GADD45GIP1 ZNF709 IER2 STX10 ZNF625
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SYCE2 on UCSC Golden Path with GeneCards custom track

Promoters for SYCE2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000107330 -57 401 HDGF PKNOX1 CREB3L1 ARNT AGO1 SIN3A ZNF2 YY1 ZNF143 ZNF207

Transcription factor binding sites by QIAGEN in the SYCE2 gene promoter:

Genomic Location for SYCE2 Gene

Chromosome:
19
Start:
12,898,786 bp from pter
End:
12,919,343 bp from pter
Size:
20,558 bases
Orientation:
Minus strand

Genomic View for SYCE2 Gene

Genes around SYCE2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SYCE2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SYCE2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYCE2 Gene

Proteins for SYCE2 Gene

  • Protein details for SYCE2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PIF2-SYCE2_HUMAN
    Recommended name:
    Synaptonemal complex central element protein 2
    Protein Accession:
    Q6PIF2
    Secondary Accessions:
    • B4DYD3

    Protein attributes for SYCE2 Gene

    Size:
    218 amino acids
    Molecular mass:
    24690 Da
    Quaternary structure:
    • Homodimer. Found in a complex with SYCP1 and SYCE1. Interacts with SYCP1, SYCE1 and SYCE3 (By similarity).

neXtProt entry for SYCE2 Gene

Post-translational modifications for SYCE2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SYCE2 Gene

No data available for DME Specific Peptides for SYCE2 Gene

Domains & Families for SYCE2 Gene

Protein Domains for SYCE2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SYCE2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6PIF2

UniProtKB/Swiss-Prot:

SYCE2_HUMAN :
  • Belongs to the SYCE family.
Family:
  • Belongs to the SYCE family.
genes like me logo Genes that share domains with SYCE2: view

No data available for Gene Families for SYCE2 Gene

Function for SYCE2 Gene

Molecular function for SYCE2 Gene

UniProtKB/Swiss-Prot Function:
Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Requires SYCP1 in order to be incorporated into the central element. May have a role in the synaptonemal complex assembly, stabilization and recombination (By similarity).
genes like me logo Genes that share phenotypes with SYCE2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SYCE2 Gene

Localization for SYCE2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYCE2 Gene

Nucleus. Note=Associates with chromatin. In prophase I stage of meiosis, localizes in the transverse central elements of the central region between lateral elements of the synaptonemal complexes. Found only where the chromosome cores are synapsed. Colocalizes with SYCE1 in the central elements (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SYCE2 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for SYCE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000801 central element ISS --
GO:0005634 nucleus IDA --
genes like me logo Genes that share ontologies with SYCE2: view

Pathways & Interactions for SYCE2 Gene

SuperPathways for SYCE2 Gene

SuperPathway Contained pathways
1 Meiosis
.73
2 Cell Cycle, Mitotic
genes like me logo Genes that share pathways with SYCE2: view

Pathways by source for SYCE2 Gene

3 Reactome pathways for SYCE2 Gene

Gene Ontology (GO) - Biological Process for SYCE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0007130 synaptonemal complex assembly NAS 15944401
GO:0051301 cell division IEA --
GO:0051321 meiotic cell cycle IEA --
genes like me logo Genes that share ontologies with SYCE2: view

No data available for SIGNOR curated interactions for SYCE2 Gene

Transcripts for SYCE2 Gene

mRNA/cDNA for SYCE2 Gene

Unigene Clusters for SYCE2 Gene

Synaptonemal complex central element protein 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SYCE2 Gene

No ASD Table

Relevant External Links for SYCE2 Gene

GeneLoc Exon Structure for
SYCE2
ECgene alternative splicing isoforms for
SYCE2

Expression for SYCE2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SYCE2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SYCE2 Gene

This gene is overexpressed in Testis (x13.7).

Protein differential expression in normal tissues from HIPED for SYCE2 Gene

This gene is overexpressed in Testis (30.6), Ovary (18.9), and Fetal ovary (18.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SYCE2 Gene



Protein tissue co-expression partners for SYCE2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SYCE2 Gene:

SYCE2

SOURCE GeneReport for Unigene cluster for SYCE2 Gene:

Hs.655173
genes like me logo Genes that share expression patterns with SYCE2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SYCE2 Gene

Orthologs for SYCE2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SYCE2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SYCE2 34 35
  • 99.69 (n)
dog
(Canis familiaris)
Mammalia SYCE2 34 35
  • 86.46 (n)
cow
(Bos Taurus)
Mammalia SYCE2 34 35
  • 85.86 (n)
mouse
(Mus musculus)
Mammalia Syce2 34 16 35
  • 78.34 (n)
rat
(Rattus norvegicus)
Mammalia Syce2 34
  • 77.71 (n)
oppossum
(Monodelphis domestica)
Mammalia SYCE2 35
  • 39 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SYCE2 35
  • 28 (a)
OneToOne
chicken
(Gallus gallus)
Aves SYCE2 34
  • 64.24 (n)
lizard
(Anolis carolinensis)
Reptilia SYCE2 35
  • 48 (a)
OneToOne
Species where no ortholog for SYCE2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SYCE2 Gene

ENSEMBL:
Gene Tree for SYCE2 (if available)
TreeFam:
Gene Tree for SYCE2 (if available)

Paralogs for SYCE2 Gene

Pseudogenes.org Pseudogenes for SYCE2 Gene

genes like me logo Genes that share paralogs with SYCE2: view

No data available for Paralogs for SYCE2 Gene

Variants for SYCE2 Gene

Sequence variations from dbSNP and Humsavar for SYCE2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs121434367 Pathogenic 12,899,486(+) TCACG(C/T)CCTGA intron-variant, nc-transcript-variant, reference, missense
rs121434368 Pathogenic 12,899,471(+) AGGTA(C/T)ACATG intron-variant, nc-transcript-variant, reference, missense
rs121434369 Pathogenic 12,897,824(+) TGATC(C/T)GGCAC nc-transcript-variant, downstream-variant-500B, reference, missense
rs121434372 Pathogenic 12,897,818(+) ATCAC(A/G)TGATC nc-transcript-variant, downstream-variant-500B, reference, missense
rs141437721 Pathogenic 12,897,833(+) ACGCC(A/G)TGAAC nc-transcript-variant, downstream-variant-500B, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for SYCE2 Gene

Variant ID Type Subtype PubMed ID
esv2668234 CNV deletion 23128226
esv3583254 CNV loss 25503493
esv3643715 CNV loss 21293372
esv3643716 CNV loss 21293372
nsv1160589 CNV duplication 26073780
nsv833754 CNV loss 17160897
nsv953977 CNV deletion 24416366

Variation tolerance for SYCE2 Gene

Residual Variation Intolerance Score: 69.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.48; 10.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SYCE2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SYCE2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SYCE2 Gene

Disorders for SYCE2 Gene

Relevant External Links for SYCE2

Genetic Association Database (GAD)
SYCE2
Human Genome Epidemiology (HuGE) Navigator
SYCE2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SYCE2

No disorders were found for SYCE2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SYCE2 Gene

Publications for SYCE2 Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  2. Two novel proteins recruited by synaptonemal complex protein 1 (SYCP1) are at the centre of meiosis. (PMID: 15944401) Costa Y. … Cooke H.J. (J. Cell. Sci. 2005) 2 3 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for SYCE2 Gene

Sources for SYCE2 Gene

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