SYCE1L Gene
protein-coding GIFtS: 33
GCID: GC16P077233
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synaptonemal complex central element protein 1-like
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Aliases
for SYCE1L gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Synaptonemal Complex Central Element Protein 1-Like1 2 | | MRP21 2 | | Meiosis-Related Protein2 3 |
Export aliases for SYCE1L gene to outside databasesPrevious GC identifers: GC16P075791 GC16P062989 |
Summaries
for SYCE1L gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: SYC1L_HUMAN, A8MT33Function: May be involved in meiosis (By similarity)
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Genomic Views
for SYCE1L gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010498.15
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for SYCE1L
Other transcription factors
Search SABiosciences Chromatin IP Primers for SYCE1L
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SYCE1L |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16q23.1 Ensembl cytogenetic band: 16q23.1 HGNC cytogenetic band: 16q23.1SYCE1L Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16P077233: view genomic region
(about GC identifiers)
Start:
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77,233,294 bp from pter |
End:
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77,247,112 bp from pter |
Size:
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13,819 bases |
Orientation:
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plus strand |
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Proteins
for SYCE1L gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SYC1L_HUMAN, A8MT33 (See
protein sequence)Recommended Name: Synaptonemal complex central element protein 1-like Size: 242 amino acids; 27397 Da
Secondary accessions: A6NF23Explore the universe of human proteins at neXtProt for SYCE1L: NX_A8MT33
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_A8MT33
SYCE1L Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001123451.1
ENSEMBL proteins: ENSP00000367911 ENSP00000454349
Human Recombinant Protein Products for SYCE1L:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000795 | synaptonemal complex |
IEA | -- |
SYCE1L for ontologies About GeneDecksing
SYCE1L Antibody Products:
Assay Products for SYCE1L: |
Protein
Domains /
Families
for SYCE1L gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SYCE1L for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry A8MT33ProtoNet protein and cluster: A8MT33 UniProtKB/Swiss-Prot: SYC1L_HUMAN, A8MT33Similarity: Belongs to the SYCE family |
Function
for SYCE1L gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: SYC1L_HUMAN, A8MT33Function: May be involved in meiosis (By similarity)Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SYCE1L (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SYCE1L
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SYCE1L (NM_001129979) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SYCE1L | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SYCE1L |
|
Pathways & Interactions
for SYCE1L gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SYCE1L
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
SYCE1L for ontologies About GeneDecksing
|
Drugs & Compounds
for SYCE1L gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SYCE1L
Search CenterWatch for drugs/clinical trials and news about SYCE1L / SYC1L
|
Transcripts
for SYCE1L gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SYCE1L gene: NM_001129979.1 Unigene Cluster for SYCE1L: Synaptonemal complex central element protein 1-like Hs.734779 [show with all ESTs]Unigene Representative Sequence: AL5126973 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000378644(uc010vnh.1 uc002ffb.3) ENST00000568925 ENST00000563157
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SYCE1L (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SYCE1L
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SYCE1L (NM_001129979) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SYCE1L | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SYCE1L |
Additional cDNA sequence: AL512697.1 BC035731.1 4 DOTS entries: DT.97808599 DT.75161141 DT.75194450 DT.97793068
GeneLoc Exon Structure
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Expression
for SYCE1L gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SYCE1L expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCGGTGAATG
About this image
See SYCE1L Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SYCE1L
SOURCE GeneReport for Unigene cluster: Hs.734779
SABiosciences Custom PCR Arrays for SYCE1L
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SYCE1L
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SYCE1L | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SYCE1L | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SYCE1L |
Orthologs
for SYCE1L gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for SYCE1L gene from 2/7 species (see all 7) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
24(a) |
1 → many |
2(69124124-69140136) |
zebrafish
(Danio rerio) |
Actinopterygii |
si:ch211-199g17.96 |
si:ch211-199g17.9 |
29(a) |
1 → many |
19(44971772-44979396) |
ENSEMBL Gene Tree for SYCE1L (if available)
TreeFam Gene Tree for SYCE1L (if available) |
Paralogs
for SYCE1L gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SYCE1L gene
- SYCE12
1 SIMAP similar gene for SYCE1L using alignment to 2 protein entries: SYC1L_HUMAN (see all proteins):SYCE1
SYCE1L for paralogs About GeneDecksing
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Genomic Variants
for SYCE1L gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SYCE1L (77233294 - 77247112 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SYCE1L: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SYCE1L |
|
Disorders
/ Diseases
for SYCE1L gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for SYCE1L gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SYCE1L gene integrated from 9 sources:
(articles sorted by number of sources associating them with SYCE1L) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of a new transcript specifically expre ssed in mouse spermatocytes: mmrp2. (PubMed id 16328886)1, 3 Gu S....Guo M. (2005)
- The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)2 Martin J.... Pennacchio L.A. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
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External Searches for SYCE1L gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing SYCE1L gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SYCE1L gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SYCE1L gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SYCE1L | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SYCE1L gene:
Search GeneIP for patents involving SYCE1L
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SYCE1L gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SYCE1L | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SYCE1L | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SYCE1L | | | OriGene Protein Over-expression Lysate for SYCE1L | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SYCE1L | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SYCE1L | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SYCE1L | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SYCE1L | | OriGene Custom Protein Services for SYCE1L | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SYCE1L | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SYCE1L | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SYCE1L | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SYCE1L | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SYCE1L | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SYCE1L |
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| | | | Search Tocris compounds for SYCE1L |
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 | | | SYCE1L Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  |  | | | | Search ThermoFisher Antibodies for SYCE1L |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SYCE1L |
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