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Aliases for SYCE1L Gene

Aliases for SYCE1L Gene

  • Synaptonemal Complex Central Element Protein 1 Like 2 3 5
  • Meiosis-Related Protein 2 3 4
  • Synaptonemal Complex Central Element Protein 1-Like 2 3
  • MRP2 3

External Ids for SYCE1L Gene

Previous GeneCards Identifiers for SYCE1L Gene

  • GC16P075791
  • GC16P062989

Summaries for SYCE1L Gene

GeneCards Summary for SYCE1L Gene

SYCE1L (Synaptonemal Complex Central Element Protein 1 Like) is a Protein Coding gene. An important paralog of this gene is SYCE1.

UniProtKB/Swiss-Prot for SYCE1L Gene

  • May be involved in meiosis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYCE1L Gene

Genomics for SYCE1L Gene

Regulatory Elements for SYCE1L Gene

Enhancers for SYCE1L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F077211 1.2 Ensembl ENCODE 65.8 +13.9 13876 3.1 PKNOX1 SIN3A GLI4 GLIS2 FOS SP3 YY2 REST ZNF610 SMARCA4 SYCE1L MON1B VN2R10P
GH16F077190 1.1 ENCODE 71 -8.0 -7995 2.6 HDGF PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF143 SYCE1L MON1B GC16P077193 PIR54148
GH16F077287 1.2 FANTOM5 Ensembl ENCODE 16.1 +90.0 90037 3.4 SCRT1 JUN BHLHE40 CEBPB MAX USF2 FEZF1 REST NR3C1 EP300 SYCE1L ENSG00000260922 MON1B ADAMTS18 ENSG00000261063 ENSG00000260701
GH16F077297 1.1 Ensembl ENCODE 13 +100.1 100082 5.0 TBP SIN3A FEZF1 RFX5 POLR3A RCOR1 FOS DEK SMARCC1 CEBPB SYCE1L ENSG00000260922 VN2R10P ADAMTS18 ENSG00000261063 ENSG00000260701
GH16F077307 1.1 Ensembl ENCODE 8.3 +108.8 108819 1.9 PKNOX1 INSM2 ZNF366 FOS CREM CEBPB JUNB ZEB2 TSHZ1 TBX21 SYCE1L ADAMTS18 ENSG00000261063 ENSG00000260701
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SYCE1L on UCSC Golden Path with GeneCards custom track

Genomic Location for SYCE1L Gene

Chromosome:
16
Start:
77,199,397 bp from pter
End:
77,213,215 bp from pter
Size:
13,819 bases
Orientation:
Plus strand

Genomic View for SYCE1L Gene

Genes around SYCE1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SYCE1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SYCE1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYCE1L Gene

Proteins for SYCE1L Gene

  • Protein details for SYCE1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8MT33-SYC1L_HUMAN
    Recommended name:
    Synaptonemal complex central element protein 1-like
    Protein Accession:
    A8MT33
    Secondary Accessions:
    • A6NF23

    Protein attributes for SYCE1L Gene

    Size:
    242 amino acids
    Molecular mass:
    27397 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SYCE1L Gene

Post-translational modifications for SYCE1L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SYCE1L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SYCE1L Gene

Domains & Families for SYCE1L Gene

Protein Domains for SYCE1L Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SYCE1L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A8MT33

UniProtKB/Swiss-Prot:

SYC1L_HUMAN :
  • Belongs to the SYCE family.
Family:
  • Belongs to the SYCE family.
genes like me logo Genes that share domains with SYCE1L: view

No data available for Gene Families for SYCE1L Gene

Function for SYCE1L Gene

Molecular function for SYCE1L Gene

UniProtKB/Swiss-Prot Function:
May be involved in meiosis.

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SYCE1L Gene

Localization for SYCE1L Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SYCE1L gene
Compartment Confidence
cytoskeleton 4
nucleus 4
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for SYCE1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000795 synaptonemal complex IEA --
genes like me logo Genes that share ontologies with SYCE1L: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SYCE1L Gene

Pathways & Interactions for SYCE1L Gene

SuperPathways for SYCE1L Gene

No Data Available

Interacting Proteins for SYCE1L Gene

Selected Interacting proteins: A8MT33-SYC1L_HUMAN for SYCE1L Gene via IID

Symbol External ID(s) Details
YWHAZ

Gene Ontology (GO) - Biological Process for SYCE1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007130 synaptonemal complex assembly IEA --
GO:0051321 meiotic cell cycle IEA --
GO:0070193 synaptonemal complex organization IEA --
genes like me logo Genes that share ontologies with SYCE1L: view

No data available for Pathways by source and SIGNOR curated interactions for SYCE1L Gene

Transcripts for SYCE1L Gene

mRNA/cDNA for SYCE1L Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SYCE1L Gene

Synaptonemal complex central element protein 1-like:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SYCE1L Gene

No ASD Table

Relevant External Links for SYCE1L Gene

GeneLoc Exon Structure for
SYCE1L
ECgene alternative splicing isoforms for
SYCE1L

Expression for SYCE1L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SYCE1L Gene

mRNA differential expression in normal tissues according to GTEx for SYCE1L Gene

This gene is overexpressed in Testis (x9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SYCE1L Gene



Protein tissue co-expression partners for SYCE1L Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SYCE1L Gene:

SYCE1L

SOURCE GeneReport for Unigene cluster for SYCE1L Gene:

Hs.734779
genes like me logo Genes that share expression patterns with SYCE1L: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SYCE1L Gene

Orthologs for SYCE1L Gene

This gene was present in the common ancestor of chordates.

Orthologs for SYCE1L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SYCE1L 34 35
  • 99.04 (n)
dog
(Canis familiaris)
Mammalia LOC100856750 34
  • 84.19 (n)
SYCE1L 35
  • 65 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SYCE1L 34 35
  • 79.11 (n)
mouse
(Mus musculus)
Mammalia Syce1l 34 16 35
  • 71.79 (n)
rat
(Rattus norvegicus)
Mammalia Syce1l 34
  • 69.33 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 32 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 22 (a)
OneToMany
Species where no ortholog for SYCE1L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SYCE1L Gene

ENSEMBL:
Gene Tree for SYCE1L (if available)
TreeFam:
Gene Tree for SYCE1L (if available)

Paralogs for SYCE1L Gene

Paralogs for SYCE1L Gene

(1) SIMAP similar genes for SYCE1L Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SYCE1L: view

Variants for SYCE1L Gene

Sequence variations from dbSNP and Humsavar for SYCE1L Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs111382505 -- 77,204,674(+) AAAAA(C/G)ATCAC intron-variant
rs11149971 -- 77,204,913(+) GGCGG(C/T)GTGCG intron-variant
rs111539392 -- 77,202,987(+) TTCCA(A/T)AATAT intron-variant
rs111549465 -- 77,203,862(+) AGTGC(G/T)GGGAT intron-variant
rs111573031 -- 77,204,677(+) AAGAT(C/T)ACTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SYCE1L Gene

Variant ID Type Subtype PubMed ID
nsv1065048 CNV gain 25217958
nsv1056676 CNV loss 25217958
nsv1055234 CNV gain 25217958
esv3639164 CNV loss 21293372
esv3582331 CNV loss 25503493
dgv3027n100 CNV gain 25217958

Variation tolerance for SYCE1L Gene

Gene Damage Index Score: 9.83; 89.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SYCE1L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SYCE1L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SYCE1L Gene

Disorders for SYCE1L Gene

Relevant External Links for SYCE1L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SYCE1L

No disorders were found for SYCE1L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SYCE1L Gene

Publications for SYCE1L Gene

  1. Identification of a new transcript specifically expressed in mouse spermatocytes: mmrp2. (PMID: 16328886) Gu S. … Guo M. (Mol. Biol. Rep. 2005) 2 3 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  3. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J. … Pennacchio L.A. (Nature 2004) 4 64

Products for SYCE1L Gene

Sources for SYCE1L Gene

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