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Aliases for SYCE1 Gene

Aliases for SYCE1 Gene

  • Synaptonemal Complex Central Element Protein 1 2 3
  • Cancer/Testis Antigen 76 2 3 4
  • C10orf94 3 4
  • CT76 3 4
  • Chromosome 10 Open Reading Frame 94 2

External Ids for SYCE1 Gene

Previous Symbols for SYCE1 Gene

  • C10orf94

Summaries for SYCE1 Gene

GeneCards Summary for SYCE1 Gene

SYCE1 (Synaptonemal Complex Central Element Protein 1) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Meiosis. An important paralog of this gene is SYCE1L.

UniProtKB/Swiss-Prot for SYCE1 Gene

  • Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Requires SYCP1 in order to be incorporated into the central element. May have a role in the synaptonemal complex assembly, stabilization and recombination (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYCE1 Gene

Genomics for SYCE1 Gene

Genomic Location for SYCE1 Gene

Start:
133,553,900 bp from pter
End:
133,569,835 bp from pter
Size:
15,936 bases
Orientation:
Minus strand

Genomic View for SYCE1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SYCE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYCE1 Gene

Regulatory Elements for SYCE1 Gene

Proteins for SYCE1 Gene

  • Protein details for SYCE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N0S2-SYCE1_HUMAN
    Recommended name:
    Synaptonemal complex central element protein 1
    Protein Accession:
    Q8N0S2
    Secondary Accessions:
    • B2RC80
    • Q9BWU3
    • Q9BWU4

    Protein attributes for SYCE1 Gene

    Size:
    351 amino acids
    Molecular mass:
    39699 Da
    Quaternary structure:
    • Homodimer. Found in a complex with SYCP1 and SYCE2. Interacts with SYCP1, SYCE2 and SYCE3 (By similarity).
    SequenceCaution:
    • Sequence=AAH34821.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for SYCE1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SYCE1 Gene

Proteomics data for SYCE1 Gene at MOPED

Post-translational modifications for SYCE1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SYCE1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SYCE1 Gene

Domains for SYCE1 Gene

Protein Domains for SYCE1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SYCE1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N0S2

UniProtKB/Swiss-Prot:

SYCE1_HUMAN
Family:
  • Belongs to the SYCE family.:
    • Q8N0S2
genes like me logo Genes that share domains with SYCE1: view

No data available for Gene Families for SYCE1 Gene

Function for SYCE1 Gene

Molecular function for SYCE1 Gene

UniProtKB/Swiss-Prot Function: Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Requires SYCP1 in order to be incorporated into the central element. May have a role in the synaptonemal complex assembly, stabilization and recombination (By similarity).

Gene Ontology (GO) - Molecular Function for SYCE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SYCE1: view
genes like me logo Genes that share phenotypes with SYCE1: view

miRNA for SYCE1 Gene

miRTarBase miRNAs that target SYCE1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SYCE1 Gene

Localization for SYCE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYCE1 Gene

Nucleus. Chromosome. Note=Associates with chromatin. In prophase I stage of meiosis, localizes in the transverse central elements of the central region between lateral elements of the synaptonemal complexes. Found only where the chromosome cores are synapsed. Colocalizes with SYCE2 in the central elements (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SYCE1 Gene COMPARTMENTS Subcellular localization image for SYCE1 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SYCE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000795 synaptonemal complex --
GO:0000801 central element ISS 15944401
genes like me logo Genes that share ontologies with SYCE1: view

Pathways for SYCE1 Gene

genes like me logo Genes that share pathways with SYCE1: view

Pathways by source for SYCE1 Gene

4 Reactome pathways for SYCE1 Gene

Gene Ontology (GO) - Biological Process for SYCE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007130 synaptonemal complex assembly IC 15944401
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with SYCE1: view

Transcripts for SYCE1 Gene

Unigene Clusters for SYCE1 Gene

Synaptonemal complex central element protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SYCE1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP1: - - - - - - - -
SP2: - - -
SP3: -
SP4: - - -
SP5:
SP6: -
SP7: -

Relevant External Links for SYCE1 Gene

GeneLoc Exon Structure for
SYCE1
ECgene alternative splicing isoforms for
SYCE1

Expression for SYCE1 Gene

mRNA expression in normal human tissues for SYCE1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SYCE1 Gene

This gene is overexpressed in Testis (16.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SYCE1 Gene

SOURCE GeneReport for Unigene cluster for SYCE1 Gene Hs.553795

genes like me logo Genes that share expressions with SYCE1: view

No data available for mRNA Expression by UniProt/SwissProt for SYCE1 Gene

Orthologs for SYCE1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SYCE1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SYCE1 35
  • 98.96 (n)
  • 98.01 (a)
SYCE1 36
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SYCE1 35
  • 83.12 (n)
  • 79.03 (a)
SYCE1 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC480826 35
  • 83.6 (n)
  • 79.29 (a)
SYCE1 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Syce1 35
  • 76.57 (n)
  • 65.94 (a)
Syce1 16
Syce1 36
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 47 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Syce1 35
  • 76.49 (n)
  • 68.34 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 33 (a)
OneToMany
Species with no ortholog for SYCE1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SYCE1 Gene

ENSEMBL:
Gene Tree for SYCE1 (if available)
TreeFam:
Gene Tree for SYCE1 (if available)

Paralogs for SYCE1 Gene

Paralogs for SYCE1 Gene

Selected SIMAP similar genes for SYCE1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SYCE1: view

Variants for SYCE1 Gene

Sequence variations from dbSNP and Humsavar for SYCE1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs755100 -- 133,558,121(+) TTCTG(C/T)GGGTT intron-variant
rs2149616 -- 133,554,659(+) ATTTC(A/G)GGGAG intron-variant, downstream-variant-500B
rs2149617 -- 133,554,821(+) CAGGT(A/C)CCAGA intron-variant, downstream-variant-500B
rs2183163 -- 133,554,958(+) GGGCC(C/T)GACCC intron-variant, utr-variant-3-prime
rs2987791 -- 133,556,556(+) ACCTT(C/G)GTCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SYCE1 Gene

Variant ID Type Subtype PubMed ID
nsv528260 CNV Loss 19592680
essv9566 CNV CNV 17122850
nsv428243 CNV Gain 18775914
esv2750853 CNV Gain 17911159
nsv470981 CNV Gain 18288195
dgv35e55 CNV Gain 17911159
dgv329e1 CNV Complex 17122850
nsv7631 CNV Loss 18451855
dgv123n27 CNV Gain 19166990
dgv890n71 CNV Gain 21882294
nsv517180 CNV Gain+Loss 19592680
dgv125n27 CNV Gain 19166990
nsv469597 CNV Gain 16826518
nsv514545 CNV Gain 21397061
dgv893n71 CNV Gain+Loss 21882294
esv33719 CNV Gain 17666407
esv28562 CNV Gain+Loss 19812545
nsv498746 CNV Loss 21111241
dgv181e199 CNV Deletion 23128226
esv2421904 CNV Duplication 20811451
nsv436819 CNV Insertion 17901297
nsv8752 CNV Gain+Loss 18304495
dgv895n71 CNV Gain 21882294
dgv330e1 CNV Complex 17122850
dgv126n27 CNV Gain 19166990
nsv818790 CNV Gain 17921354
dgv127n27 CNV Gain 19166990
esv2750875 CNV Loss 17911159
dgv36e55 CNV Gain 17911159
dgv896n71 CNV Gain 21882294
nsv832042 CNV Gain 17160897
dgv128n27 CNV Gain 19166990
dgv898n71 CNV Gain 21882294
dgv900n71 CNV Gain 21882294
dgv37e55 CNV Gain 17911159
nsv442594 CNV CNV 18776908
nsv896392 CNV Gain 21882294
dgv903n71 CNV Gain 21882294
dgv904n71 CNV Gain 21882294
dgv905n71 CNV Gain 21882294
dgv331e1 CNV Complex 17122850
dgv906n71 CNV Gain 21882294
dgv129n27 CNV Gain 19166990
dgv8n64 CNV Gain 17921354
nsv819137 CNV Loss 19587683
dgv908n71 CNV Gain 21882294
nsv896424 CNV Gain 21882294
essv9488 CNV CNV 17122850
nsv482151 CNV Gain 20164927
esv35157 CNV Gain 17911159
dgv909n71 CNV Loss 21882294
nsv896428 CNV Gain 21882294
esv2419070 CNV Deletion 18987734
esv1354504 CNV Deletion 17803354

Relevant External Links for SYCE1 Gene

HapMap Linkage Disequilibrium report
SYCE1
Human Gene Mutation Database (HGMD)
SYCE1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SYCE1 Gene

Disorders for SYCE1 Gene

Relevant External Links for SYCE1

Human Genome Epidemiology (HuGE) Navigator
SYCE1
genes like me logo Genes that share disorders with SYCE1: view

No data available for UniProtKB/Swiss-Prot for SYCE1 Gene

Publications for SYCE1 Gene

  1. Genomic analysis of human chromosome 10q and 4q telomeres suggests a common origin. (PMID: 11829491) van Geel M. … Hewitt J.E. (Genomics 2002) 2 3 4
  2. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Two novel proteins recruited by synaptonemal complex protein 1 (SYCP1) are at the centre of meiosis. (PMID: 15944401) Costa Y. … Cooke H.J. (J. Cell. Sci. 2005) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for SYCE1 Gene

Sources for SYCE1 Gene

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