Aliases for SYCE1 Gene
External Ids for SYCE1 Gene
Previous HGNC Symbols for SYCE1 Gene
Previous GeneCards Identifiers for SYCE1 Gene
This gene encodes a member of the synaptonemal complex, which links homologous chromosomes during prophase I of meiosis. The tripartite structure of the complex is highly conserved amongst metazoans. It consists of two lateral elements and a central region formed by transverse elements and a central element. The protein encoded by this gene localizes to the central element and is required for initiation and elongation of the synapsis. Allelic variants of this gene have been associated with premature ovarian failure and spermatogenic failure. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]
GeneCards Summary for SYCE1 Gene
SYCE1 (Synaptonemal Complex Central Element Protein 1) is a Protein Coding gene. Diseases associated with SYCE1 include Premature Ovarian Failure and Premature Menopause. Among its related pathways are Meiosis and Cell Cycle, Mitotic. An important paralog of this gene is SYCE1L.
UniProtKB/Swiss-Prot for SYCE1 Gene
Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Requires SYCP1 in order to be incorporated into the central element. May have a role in the synaptonemal complex assembly, stabilization and recombination (By similarity).