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Aliases for SYCE1 Gene

Aliases for SYCE1 Gene

  • Synaptonemal Complex Central Element Protein 1 2 3 5
  • Cancer/Testis Antigen 76 2 3 4
  • C10orf94 3 4
  • CT76 3 4
  • Chromosome 10 Open Reading Frame 94 2
  • SPGF15 3
  • POF12 3

External Ids for SYCE1 Gene

Previous HGNC Symbols for SYCE1 Gene

  • C10orf94

Previous GeneCards Identifiers for SYCE1 Gene

  • GC10M135257
  • GC10M135217
  • GC10M135367
  • GC10M128909

Summaries for SYCE1 Gene

Entrez Gene Summary for SYCE1 Gene

  • This gene encodes a member of the synaptonemal complex, which links homologous chromosomes during prophase I of meiosis. The tripartite structure of the complex is highly conserved amongst metazoans. It consists of two lateral elements and a central region formed by transverse elements and a central element. The protein encoded by this gene localizes to the central element and is required for initiation and elongation of the synapsis. Allelic variants of this gene have been associated with premature ovarian failure and spermatogenic failure. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]

GeneCards Summary for SYCE1 Gene

SYCE1 (Synaptonemal Complex Central Element Protein 1) is a Protein Coding gene. Diseases associated with SYCE1 include Premature Ovarian Failure and Premature Menopause. Among its related pathways are Meiosis and Cell Cycle, Mitotic. An important paralog of this gene is SYCE1L.

UniProtKB/Swiss-Prot for SYCE1 Gene

  • Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Requires SYCP1 in order to be incorporated into the central element. May have a role in the synaptonemal complex assembly, stabilization and recombination (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYCE1 Gene

Genomics for SYCE1 Gene

Regulatory Elements for SYCE1 Gene

Enhancers for SYCE1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10F133516 0.3 FANTOM5 4.5 +53.4 53366 0.4 TEAD1 TEAD3 CYP2E1 SYCE1 LOC105378575
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SYCE1 on UCSC Golden Path with GeneCards custom track

Promoters for SYCE1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001765568 735 601

Genomic Location for SYCE1 Gene

Chromosome:
10
Start:
133,553,900 bp from pter
End:
133,569,835 bp from pter
Size:
15,936 bases
Orientation:
Minus strand

Genomic View for SYCE1 Gene

Genes around SYCE1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SYCE1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SYCE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYCE1 Gene

Proteins for SYCE1 Gene

  • Protein details for SYCE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N0S2-SYCE1_HUMAN
    Recommended name:
    Synaptonemal complex central element protein 1
    Protein Accession:
    Q8N0S2
    Secondary Accessions:
    • B2RC80
    • Q9BWU3
    • Q9BWU4

    Protein attributes for SYCE1 Gene

    Size:
    351 amino acids
    Molecular mass:
    39699 Da
    Quaternary structure:
    • Homodimer. Found in a complex with SYCP1 and SYCE2. Interacts with SYCP1, SYCE2 and SYCE3 (By similarity).
    SequenceCaution:
    • Sequence=AAH34821.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for SYCE1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SYCE1 Gene

Post-translational modifications for SYCE1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SYCE1 Gene

No data available for DME Specific Peptides for SYCE1 Gene

Domains & Families for SYCE1 Gene

Protein Domains for SYCE1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SYCE1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N0S2

UniProtKB/Swiss-Prot:

SYCE1_HUMAN :
  • Belongs to the SYCE family.
Family:
  • Belongs to the SYCE family.
genes like me logo Genes that share domains with SYCE1: view

No data available for Gene Families for SYCE1 Gene

Function for SYCE1 Gene

Molecular function for SYCE1 Gene

UniProtKB/Swiss-Prot Function:
Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Requires SYCP1 in order to be incorporated into the central element. May have a role in the synaptonemal complex assembly, stabilization and recombination (By similarity).

Gene Ontology (GO) - Molecular Function for SYCE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SYCE1: view
genes like me logo Genes that share phenotypes with SYCE1: view

Animal Models for SYCE1 Gene

MGI Knock Outs for SYCE1:

Animal Model Products

miRNA for SYCE1 Gene

miRTarBase miRNAs that target SYCE1

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SYCE1 Gene

Localization for SYCE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYCE1 Gene

Nucleus. Chromosome. Note=Associates with chromatin. In prophase I stage of meiosis, localizes in the transverse central elements of the central region between lateral elements of the synaptonemal complexes. Found only where the chromosome cores are synapsed. Colocalizes with SYCE2 in the central elements (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SYCE1 Gene COMPARTMENTS Subcellular localization image for SYCE1 gene
Compartment Confidence
nucleus 5
cytosol 4
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SYCE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000801 central element ISS 15944401
GO:0005634 nucleus IEA --
GO:0005694 chromosome IEA --
GO:0031225 anchored component of membrane IEA --
genes like me logo Genes that share ontologies with SYCE1: view

Pathways & Interactions for SYCE1 Gene

SuperPathways for SYCE1 Gene

SuperPathway Contained pathways
1 Meiosis
.73
2 Cell Cycle, Mitotic
genes like me logo Genes that share pathways with SYCE1: view

Pathways by source for SYCE1 Gene

3 Reactome pathways for SYCE1 Gene

Gene Ontology (GO) - Biological Process for SYCE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0007130 synaptonemal complex assembly IC 15944401
GO:0051301 cell division IEA --
GO:0051321 meiotic cell cycle IEA --
GO:0070193 synaptonemal complex organization IEA --
genes like me logo Genes that share ontologies with SYCE1: view

No data available for SIGNOR curated interactions for SYCE1 Gene

Transcripts for SYCE1 Gene

Unigene Clusters for SYCE1 Gene

Synaptonemal complex central element protein 1:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SYCE1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP1: - - - - - - - -
SP2: - - -
SP3: -
SP4: - - -
SP5:
SP6: -
SP7: -

Relevant External Links for SYCE1 Gene

GeneLoc Exon Structure for
SYCE1
ECgene alternative splicing isoforms for
SYCE1

Expression for SYCE1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SYCE1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SYCE1 Gene

This gene is overexpressed in Testis (x16.9).

Protein differential expression in normal tissues from HIPED for SYCE1 Gene

This gene is overexpressed in Synovial fluid (25.0), Lymph node (15.0), Testis (12.9), and Fetal ovary (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SYCE1 Gene



NURSA nuclear receptor signaling pathways regulating expression of SYCE1 Gene:

SYCE1

SOURCE GeneReport for Unigene cluster for SYCE1 Gene:

Hs.553795
genes like me logo Genes that share expression patterns with SYCE1: view

Primer Products

No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for SYCE1 Gene

Orthologs for SYCE1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SYCE1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SYCE1 34 35
  • 98.96 (n)
dog
(Canis familiaris)
Mammalia LOC480826 34
  • 83.6 (n)
SYCE1 35
  • 76 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SYCE1 34 35
  • 83.12 (n)
mouse
(Mus musculus)
Mammalia Syce1 34 16 35
  • 76.57 (n)
rat
(Rattus norvegicus)
Mammalia Syce1 34
  • 76.49 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 47 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 33 (a)
OneToMany
Species where no ortholog for SYCE1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SYCE1 Gene

ENSEMBL:
Gene Tree for SYCE1 (if available)
TreeFam:
Gene Tree for SYCE1 (if available)

Paralogs for SYCE1 Gene

Paralogs for SYCE1 Gene

(1) SIMAP similar genes for SYCE1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SYCE1: view

Variants for SYCE1 Gene

Sequence variations from dbSNP and Humsavar for SYCE1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs774225566 Pathogenic 133,558,953(+) TTTGC(C/T)TCACC splice-acceptor-variant
rs875989885 Pathogenic 133,555,706(-) CCAGG(C/T)AGCTG reference, stop-gained
rs10659883 -- 133,563,703(+) AAAAA(-/AA)TCAAG intron-variant
rs10857748 -- 133,558,806(+) CTGAT(C/T)ATCTG intron-variant
rs10857749 -- 133,559,093(+) CTTGC(C/T)AGGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SYCE1 Gene

Variant ID Type Subtype PubMed ID
dgv1000n100 CNV gain 25217958
dgv1001n100 CNV gain 25217958
dgv1003n100 CNV gain+loss 25217958
dgv1004n100 CNV loss 25217958
dgv1006n100 CNV gain 25217958
dgv1007n100 CNV gain 25217958
dgv123n27 CNV gain 19166990
dgv125n27 CNV gain 19166990
dgv126n27 CNV gain 19166990
dgv127n27 CNV gain 19166990
dgv128n27 CNV gain 19166990
dgv129n27 CNV gain 19166990
dgv1486n54 CNV gain 21841781
dgv1487n54 CNV gain 21841781
dgv1492n54 CNV loss 21841781
dgv1493n54 CNV gain 21841781
dgv1494n54 CNV gain+loss 21841781
dgv1495n54 CNV gain 21841781
dgv1496n54 CNV gain 21841781
dgv1497n54 CNV loss 21841781
dgv1498n54 CNV gain 21841781
dgv1499n54 CNV loss 21841781
dgv1500n54 CNV loss 21841781
dgv172e214 CNV gain 21293372
dgv174e214 CNV gain 21293372
dgv181e199 CNV deletion 23128226
dgv304e212 CNV gain 25503493
dgv305e212 CNV gain 25503493
dgv35e55 CNV gain 17911159
dgv36e55 CNV gain 17911159
dgv37e55 CNV gain 17911159
dgv8n64 CNV gain 17921354
dgv999n100 CNV gain 25217958
esv1354504 CNV deletion 17803354
esv2419070 CNV deletion 18987734
esv2421904 CNV duplication 20811451
esv2750853 CNV gain 17911159
esv2750875 CNV loss 17911159
esv2759793 CNV gain+loss 17122850
esv2760130 CNV gain+loss 21179565
esv2764146 CNV gain+loss 21179565
esv28562 CNV gain+loss 19812545
esv33719 CNV gain 17666407
esv3439276 CNV duplication 20981092
esv35157 CNV gain 17911159
esv3579237 CNV loss 25503493
esv3579239 CNV loss 25503493
esv3625046 CNV loss 21293372
esv3625052 CNV loss 21293372
esv3891902 CNV gain+loss 25118596
esv3891903 CNV gain 25118596
nsv1043323 CNV gain 25217958
nsv1052904 CNV gain 25217958
nsv1075825 CNV duplication 25765185
nsv1137976 CNV deletion 24896259
nsv1159789 CNV duplication 26073780
nsv428243 CNV gain 18775914
nsv436819 CNV insertion 17901297
nsv442594 CNV gain 18776908
nsv469597 CNV gain 16826518
nsv470981 CNV gain 18288195
nsv482151 CNV gain 20164927
nsv498746 CNV loss 21111241
nsv514545 CNV gain 21397061
nsv517180 CNV gain+loss 19592680
nsv528260 CNV loss 19592680
nsv552589 CNV gain 21841781
nsv552721 CNV gain 21841781
nsv552725 CNV gain 21841781
nsv552726 CNV gain 21841781
nsv552727 CNV gain 21841781
nsv552729 CNV gain 21841781
nsv552732 CNV gain 21841781
nsv552740 CNV loss 21841781
nsv7631 CNV deletion 18451855
nsv818790 CNV gain 17921354
nsv819137 CNV loss 19587683
nsv832042 CNV gain 17160897
nsv8752 CNV gain+loss 18304495
nsv952711 CNV deletion 24416366

Variation tolerance for SYCE1 Gene

Residual Variation Intolerance Score: 93.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.72; 83.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SYCE1 Gene

Human Gene Mutation Database (HGMD)
SYCE1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SYCE1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SYCE1 Gene

Disorders for SYCE1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SYCE1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
premature ovarian failure
  • premature menopause
premature menopause
  • menopause - premature
- elite association - COSMIC cancer census association via MalaCards
Search SYCE1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

SYCE1_HUMAN
  • Premature ovarian failure 12 (POF12) [MIM:616947]: An ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol. {ECO:0000269 PubMed:25062452}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Spermatogenic failure, 15 (SPGF15) [MIM:616950]: An infertility disorder caused by spermatogenesis defects and characterized by non-obstructive azoospermia due to complete meiotic maturation arrest. SPGF15 inheritance is autosomal recessive. {ECO:0000269 PubMed:25899990}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for SYCE1

Human Genome Epidemiology (HuGE) Navigator
SYCE1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SYCE1
genes like me logo Genes that share disorders with SYCE1: view

No data available for Genatlas for SYCE1 Gene

Publications for SYCE1 Gene

  1. Genomic analysis of human chromosome 10q and 4q telomeres suggests a common origin. (PMID: 11829491) van Geel M. … Hewitt J.E. (Genomics 2002) 2 3 4 64
  2. Deleterious mutation in SYCE1 is associated with non-obstructive azoospermia. (PMID: 25899990) Maor-Sagie E. … Frumkin A. (J. Assist. Reprod. Genet. 2015) 3 4 64
  3. Exome sequencing reveals SYCE1 mutation associated with autosomal recessive primary ovarian insufficiency. (PMID: 25062452) de Vries L. … Basel-Vanagaite L. (J. Clin. Endocrinol. Metab. 2014) 3 4 64
  4. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for SYCE1 Gene

Sources for SYCE1 Gene

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