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SYBU Gene

protein-coding   GIFtS: 52
GCID: GC08M110586

Syntabulin (Syntaxin-Interacting)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Syntabulin (Syntaxin-Interacting)1 2     Golgi-Localized Protein2
GOLSYN2 3 5     GOLSYN A Protein2
Golgi-Localized Syntaphilin-Related Protein2 3     GOLSYN B Protein2
Syntaxin-1-Binding Protein2 3     GOLSYN C Protein2
KIAA14723 5     Implicated In Syntaxin Trafficking In Neurons2
syntaphilin-like1     Microtubule-Associated Protein2
OCSYN2     syntabulin2
SNPHL2     

External Ids:    HGNC: 260111   Entrez Gene: 556382   Ensembl: ENSG000001476427   OMIM: 6115685   UniProtKB: Q9NX953   

Export aliases for SYBU gene to outside databases

Previous GC identifer: GC08M105908


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SYBU Gene:
Syntabulin/GOLSYN is part of a kinesin motor-adaptor complex that is critical for the anterograde axonal transport
of active zone components and contributes to activity-dependent presynaptic assembly during neuronal development
(Cai et al., 2007 (PubMed 17611281)).(supplied by OMIM, Mar 2008)

GeneCards Summary for SYBU Gene:
SYBU (syntabulin (syntaxin-interacting)) is a protein-coding gene. Diseases associated with SYBU include neuronitis, and choroiditis. GO annotations related to this gene include kinesin binding and syntaxin-1 binding. An important paralog of this gene is SNPH.

UniProtKB/Swiss-Prot: SYBU_HUMAN, Q9NX95
Function: Part of a kinesin motor-adapter complex that is critical for the anterograde axonal transport of active
zone components and contributes to activity-dependent presynaptic assembly during neuronal development (By
similarity)

Gene Wiki entry for SYBU (GOLSYN) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000008.11  NT_008046.17  NC_018919.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for SYBU
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSYBU promoter sequence
   Search Chromatin IP Primers for SYBU

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SYBU


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q23.2   Ensembl cytogenetic band:  8q23.2   HGNC cytogenetic band: 8q23.2

SYBU Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SYBU gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M110586:  view genomic region     (about GC identifiers)

Start:
110,586,207 bp from pter      End:
110,704,020 bp from pter
Size:
117,814 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SYBU_HUMAN, Q9NX95 (See protein sequence)
Recommended Name: Syntabulin  
Size: 663 amino acids; 72388 Da
Subunit: Interacts with STX1A and KIF5B
Secondary accessions: A8K354 B3KQX3 B3KU61 Q5R1T1 Q5R1T2 Q5R1T3 Q5Y2M6 Q8ND49 Q8TCR6 Q96D80
Q9P256
Alternative splicing: 5 isoforms:  Q9NX95-1   Q9NX95-2   Q9NX95-3   Q9NX95-4   Q9NX95-5   

Explore the universe of human proteins at neXtProt for SYBU: NX_Q9NX95

Explore proteomics data for SYBU at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SYBU Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (15 alternative transcripts): 
    NP_001093213.1  NP_001093214.1  NP_001093215.1  NP_001093216.1  NP_001093217.1  NP_001093218.1  NP_001093219.1  NP_001093220.1  
    NP_001093221.1  NP_001093222.1  NP_001093223.1  NP_001093224.1  NP_001093225.1  NP_001093226.1  NP_060256.3  

    ENSEMBL proteins: 
     ENSP00000433446   ENSP00000415654   ENSP00000436266   ENSP00000382019   ENSP00000414748  
     ENSP00000436041   ENSP00000434871   ENSP00000276646   ENSP00000432501   ENSP00000432962  
     ENSP00000433941   ENSP00000434679   ENSP00000431492   ENSP00000436850   ENSP00000436797  
     ENSP00000432835   ENSP00000434074   ENSP00000436908   ENSP00000431469   ENSP00000435433  
     ENSP00000434158   ENSP00000434840   ENSP00000435224   ENSP00000432291   ENSP00000436520  
     ENSP00000434061   ENSP00000431895   ENSP00000434612   ENSP00000407118   ENSP00000402652  
     ENSP00000403544   ENSP00000386154   ENSP00000404369   ENSP00000386196  

    SYBU Human Recombinant Protein Products:

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    SYBU Assay Products:

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    Cloud-Clone Corp. CLIAs for SYBU


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR026198 Syntabulin
     IPR028197 Syntaphilin/Syntabulin

    Graphical View of Domain Structure for InterPro Entry Q9NX95

    ProtoNet protein and cluster: Q9NX95


    SYBU for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SYBU_HUMAN, Q9NX95
    Function: Part of a kinesin motor-adapter complex that is critical for the anterograde axonal transport of active
    zone components and contributes to activity-dependent presynaptic assembly during neuronal development (By
    similarity)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16713569
    GO:0008017microtubule binding IEA--
    GO:0017075syntaxin-1 binding IEA--
    GO:0019894kinesin binding IEA--
         
    SYBU for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SYBU:
     Increased G1 DNA content 

    Animal Models:
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SYBU
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    miRNA
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    miRTarBase miRNAs that target SYBU:
    hsa-mir-130b-3p (MIRT020241), hsa-mir-19b-3p (MIRT031204), hsa-mir-32-5p (MIRT028295), hsa-mir-93-5p (MIRT027999)

    Block miRNA regulation of human, mouse, rat SYBU using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SYBU (see all 18):
    hsa-miR-3673 hsa-miR-3194-5p hsa-miR-301a hsa-miR-499-5p hsa-miR-1276 hsa-miR-3658 hsa-miR-130b hsa-miR-31*
    SwitchGear 3'UTR luciferase reporter plasmidSYBU 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for SYBU
    Predesigned siRNA for gene silencing in human, mouse, rat SYBU

    Gene Editing
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    OriGene ORF clones in mouse, rat for SYBU
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    GenScript: all cDNA clones in your preferred vector (see all 15): SYBU (NM_001099753)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SYBU
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYBU

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYBU


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SYBU_HUMAN, Q9NX95: Isoform 1: Cytoplasm, cytoskeleton. Cytoplasmic vesicle. Note=Colocalizes with syntaxin
    vesicles along microtubules in neuronal processes
    SYBU_HUMAN, Q9NX95: Isoform 3: Golgi apparatus membrane; Single-pass membrane protein
    SYBU_HUMAN, Q9NX95: Isoform 4: Golgi apparatus membrane; Single-pass membrane protein
    SYBU_HUMAN, Q9NX95: Isoform 5: Golgi apparatus membrane; Single-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    golgi apparatus5
    cytosol2
    mitochondrion1
    nucleus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005856cytoskeleton IEA--
    GO:0016021integral component of membrane IEA--
    GO:0016023cytoplasmic membrane-bounded vesicle IEA--
    GO:0097433dense body IEA--

    SYBU for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SYBU
    Interactions:

        Search GeneGlobe Interaction Network for SYBU

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for SYBU (Q9NX951, 2, 3 ENSP000002766464) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATXN1P542531, 2, 3, ENSP000002447694EBI-948293,EBI-930964 MINT-2874423 MINT-2874442 MINT-2874461 I2D: score=3 STRING: ENSP00000244769
    RPL29P479142, 3, ENSP000002941894MINT-63765 I2D: score=5 STRING: ENSP00000294189
    DTNBP1Q96EV83, ENSP000003416804I2D: score=2 STRING: ENSP00000341680
    KIF5BP331763, ENSP000003070784I2D: score=1 STRING: ENSP00000307078
    EXOC1Q9NV703, ENSP000003265144I2D: score=1 STRING: ENSP00000326514
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0061178regulation of insulin secretion involved in cellular response to glucose stimulus IEA--

    SYBU for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SYBU



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SYBU gene (15 alternative transcripts): 
    NM_001099743.1  NM_001099744.1  NM_001099745.1  NM_001099746.1  NM_001099747.1  NM_001099748.1  NM_001099749.1  NM_001099750.1  
    NM_001099751.1  NM_001099752.1  NM_001099753.1  NM_001099754.1  NM_001099755.1  NM_001099756.1  NM_017786.5  

    Unigene Cluster for SYBU:

    Syntabulin (syntaxin-interacting)
    Hs.390738  [show with all ESTs]
    Unigene Representative Sequence: AB195679
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 39):
    ENST00000533895 ENST00000424158(uc010mct.3) ENST00000532779(uc011lhw.2)
    ENST00000399066(uc003yni.4) ENST00000446070 ENST00000528331 ENST00000529175(uc003ynh.4)
    ENST00000276646(uc003ynk.4 uc003ynj.4 uc010mco.3) ENST00000528647
    ENST00000533065 ENST00000529690 ENST00000533171 ENST00000527707 ENST00000533394
    ENST00000532594 ENST00000528045 ENST00000527664 ENST00000528735
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate SYBU (see all 18):
    hsa-miR-3673 hsa-miR-3194-5p hsa-miR-301a hsa-miR-499-5p hsa-miR-1276 hsa-miR-3658 hsa-miR-130b hsa-miR-31*
    SwitchGear 3'UTR luciferase reporter plasmidSYBU 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SYBU
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    GenScript: all cDNA clones in your preferred vector (see all 15): SYBU (NM_001099753)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SYBU
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SYBU
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for SYBU
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SYBU
      QuantiTect SYBR Green Assays in human, mouse, rat SYBU
      QuantiFast Probe-based Assays in human, mouse, rat SYBU

    Additional mRNA sequence: 

    AB040905.1 AB195676.1 AB195677.1 AB195678.1 AB195679.1 AK000373.1 AK055246.1 AK090559.1 
    AK093952.1 AK096558.1 AK290469.1 AK297182.1 AL713645.1 AL834406.1 AY705385.1 BC012082.1 

    20 DOTS entries:

    DT.444579  DT.120642776  DT.95269030  DT.100754966  DT.95269032  DT.120642737  DT.101956548  DT.95269031 
    DT.120642768  DT.100754964  DT.91720083  DT.120642684  DT.100754968  DT.97822923  DT.99927828  DT.120642765 
    DT.120642682  DT.120642696  DT.120642744  DT.120642754 

    Selected AceView cDNA sequences (see all 124):

    AK090559 CD702811 AW517294 AW005782 BM921662 AA937104 AL713645 BM695876 
    AK055246 BM666954 AA255630 BX094310 BC012082 AI004340 BI917062 CR607313 
    AI861965 BM921663 AK091374 AA878208 Z38812 BU607867 AI889021 AL834406 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SYBU (see all 9)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d · 7e
    SP1:                    -     -           -     -     -                                                                           
    SP2:                          -           -     -     -                                                                           
    SP3:        -     -     -     -           -     -     -                                                                           
    SP4:                    -     -           -     -     -                 -     -     -                                             
    SP5:                    -     -                 -     -                                                                           


    ECgene alternative splicing isoforms for SYBU

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SYBU expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGAAAATAA
    SYBU Expression
    About this image


    SYBU expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Cerebral Cortex
             ganglion/cranial/facial VII   
     
     Pancreas (Endocrine System)
    SYBU Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SYBU Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.390738

    UniProtKB/Swiss-Prot: SYBU_HUMAN, Q9NX95
    Tissue specificity: Isoform 3, isoform 4 and isoform 5 are expressed in HeLa cell line (at protein level). Isoform
    3 is expressed in fetal and adult brain. Isoform 4 is expressed in numerous fetal tissues (brain, kidney, liver,
    lung, and thymus) and in adult brain, kidney, liver, lung, pancreas, colon, prostate, small intestine, testis and
    thymus. Isoform 5 is expressed in fetal brain, brain and small intestine

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SYBU

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SYBU gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sybu1 , 5 syntabulin (syntaxin-interacting)1, 5 83.96(n)1
    85.78(a)1
      15 (16.91 cM)5
    3196131  NM_001285840.11  NP_001272769.11 
     446718595 
    chicken
    (Gallus gallus)
    Aves SYBU1 syntabulin (syntaxin-interacting) 68.28(n)
    66.26(a)
      420277  XM_418389.4  XP_418389.4 
    lizard
    (Anolis carolinensis)
    Reptilia SYBU6
    syntabulin (syntaxin-interacting)
    59(a)
    1 ↔ 1
    4(10708651-10738992)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.84412 Xenopus laevis transcribed sequence with weak similarity more 77.58(n)    CD361419.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sybu1 syntabulin (syntaxin-interacting) 56.16(n)
    50.17(a)
      568207  NM_001077173.1  NP_001070641.1 


    ENSEMBL Gene Tree for SYBU (if available)
    TreeFam Gene Tree for SYBU (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SYBU gene
    SNPH2  
    1 SIMAP similar gene for SYBU using alignment to 17 protein entries:     SYBU_HUMAN (see all proteins):
    SNPH

    SYBU for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SYBU (see all 2382)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs713059611,2
    C--105947219(+) AAAAAA/-GAAAG 15 -- int11Minor allele frequency- -:0.00NA 2
    rs1823636831,2
    --110586058(+) CCCTCA/TTCCTA 15 -- ds50010--------
    rs1446558361,2
    C--110586133(+) TTAGAG/TCAACC 15 -- ds50010--------
    rs47342151,2
    C,F,H--110586134(+) TAGATC/AAACCC 15 -- ds50017Minor allele frequency- A:0.01NS EA NA 584
    rs1434514841,2
    C--110586141(+) ACCCAA/GTGTTC 15 -- ds50010--------
    rs1437046291,2
    C--110586290(+) AACTA-/ACTC  
            
    TTTTT
    15 -- ds50010--------
    rs748763501,2
    C--110586338(+) CCCTAG/TTGATA 15 -- ds50010--------
    rs1460057081,2
    C--110586342(+) TTGAT-/AAAG  
            
    AAAGA
    15 -- ds50010--------
    rs2008687941,2
    C--110586388(+) GAAGT-/AAAAAT 15 -- ds50010--------
    rs1161489111,2
    C,F--110586426(+) GGATAA/GAACAT 15 -- ut311Minor allele frequency- G:0.03WA 118

    HapMap Linkage Disequilibrium report for SYBU (110586207 - 110704020 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for SYBU:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv398033CNV Insertion16902084
    esv1058770CNV Insertion17803354
    nsv396337CNV Insertion16902084
    esv993723CNV Insertion20482838
    nsv519645CNV Loss19592680
    esv275395CNV Gain+Loss21479260

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SYBU
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611568    OMIM disorders: --

    7 diseases for SYBU:    
    About MalaCards
    neuronitis    choroiditis    glaucoma    schizophrenia
    ataxia    prostatitis    cerebritis


    SYBU for disorders           About GeneDecksing

    Genetic Association Database (GAD): SYBU
    Human Genome Epidemiology (HuGE) Navigator: SYBU (1 document)

    Export disorders for SYBU gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SYBU gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with SYBU)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of gene for Golgi-localized syntaphilin-related protein on human chromosome 8q23. (PubMed id 15656992)1, 2, 3 Funakoshi E.... Ito F. (Gene 2005)
    2. Syntabulin is a microtubule-associated protein implicated in syntaxin transport in neurons. (PubMed id 15459722)1, 2, 3 Su Q.... Sheng Z.-H. (Nat. Cell Biol. 2004)
    3. Syntabulin-kinesin-1 family member 5B-mediated axonal transport contributes to activity-dependent presynaptic assembly. (PubMed id 17611281)1, 3 Cai Q....Sheng Z.H. (J. Neurosci. 2007)
    4. Expression of m-Golsyn/Syntabulin gene during mouse brain development. (PubMed id 16750881)1, 3 Funakoshi E....Ito F. (Neurosci. Lett. 2006)
    5. Syntabulin-mediated anterograde transport of mitochondria along neuronal processes. (PubMed id 16157705)1, 3 Cai Q....Sheng Z.H. (J. Cell Biol. 2005)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)1, 2 Nagase T.... Ohara O. (DNA Res. 2000)
    8. The microtubule associated protein syntabulin is required for glucose-stimulated and cAMP-potentiated insulin secretion. (PubMed id 22975310)1 Ying Y....Ma X. (FEBS Lett. 2012)
    9. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    10. Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study. (PubMed id 17903294)4 Yang Q....O'Donnell C.J. (BMC Med. Genet. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55638 HGNC: 26011 AceView: FLJ20366 Ensembl:ENSG00000147642 euGenes: HUgn55638
    ECgene: SYBU H-InvDB: SYBU

    (According to HUGE)
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    HUGE: KIAA1472

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SYBU Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SYBU gene:
    Search GeneIP for patents involving SYBU

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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