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Aliases for SYBU Gene

Aliases for SYBU Gene

  • Syntabulin (Syntaxin-Interacting) 2 3
  • GOLSYN 3 4 6
  • Golgi-Localized Syntaphilin-Related Protein 3 4
  • Syntaxin-1-Binding Protein 3 4
  • KIAA1472 4 6
  • Implicated In Syntaxin Trafficking In Neurons 3
  • Microtubule-Associated Protein 3
  • Golgi-Localized Protein 3
  • Syntaphilin-Like 2
  • GOLSYN A Protein 3
  • GOLSYN B Protein 3
  • GOLSYN C Protein 3
  • Syntabulin 3
  • OCSYN 3
  • SNPHL 3

External Ids for SYBU Gene

Previous GeneCards Identifiers for SYBU Gene

  • GC08M110586
  • GC08M105908

Summaries for SYBU Gene

Entrez Gene Summary for SYBU Gene

  • Syntabulin/GOLSYN is part of a kinesin motor-adaptor complex that is critical for the anterograde axonal transport of active zone components and contributes to activity-dependent presynaptic assembly during neuronal development (Cai et al., 2007 [PubMed 17611281]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SYBU Gene

SYBU (Syntabulin (Syntaxin-Interacting)) is a Protein Coding gene. GO annotations related to this gene include kinesin binding and syntaxin-1 binding. An important paralog of this gene is SNPH.

UniProtKB/Swiss-Prot for SYBU Gene

  • Part of a kinesin motor-adapter complex that is critical for the anterograde axonal transport of active zone components and contributes to activity-dependent presynaptic assembly during neuronal development.

Gene Wiki entry for SYBU Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYBU Gene

Genomics for SYBU Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SYBU Gene

Start:
109,573,978 bp from pter
End:
109,691,791 bp from pter
Size:
117,814 bases
Orientation:
Minus strand

Genomic View for SYBU Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SYBU Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYBU Gene

No data available for Regulatory Elements for SYBU Gene

Proteins for SYBU Gene

  • Protein details for SYBU Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NX95-SYBU_HUMAN
    Recommended name:
    Syntabulin
    Protein Accession:
    Q9NX95
    Secondary Accessions:
    • A8K354
    • B3KQX3
    • B3KU61
    • Q5R1T1
    • Q5R1T2
    • Q5R1T3
    • Q5Y2M6
    • Q8ND49
    • Q8TCR6
    • Q96D80
    • Q9P256

    Protein attributes for SYBU Gene

    Size:
    663 amino acids
    Molecular mass:
    72388 Da
    Quaternary structure:
    • Interacts with STX1A and KIF5B.

    Alternative splice isoforms for SYBU Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SYBU Gene

Proteomics data for SYBU Gene at MOPED

Post-translational modifications for SYBU Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SYBU Gene

Domains for SYBU Gene

Protein Domains for SYBU Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SYBU: view

No data available for Gene Families and UniProtKB/Swiss-Prot for SYBU Gene

Function for SYBU Gene

Molecular function for SYBU Gene

UniProtKB/Swiss-Prot Function: Part of a kinesin motor-adapter complex that is critical for the anterograde axonal transport of active zone components and contributes to activity-dependent presynaptic assembly during neuronal development.

Gene Ontology (GO) - Molecular Function for SYBU Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15459722
GO:0008017 microtubule binding IEA --
GO:0017075 syntaxin-1 binding IEA --
GO:0019894 kinesin binding IEA --
genes like me logo Genes that share ontologies with SYBU: view

Phenotypes for SYBU Gene

GenomeRNAi human phenotypes for SYBU:
genes like me logo Genes that share phenotypes with SYBU: view

Animal Model Products

miRNA for SYBU Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SYBU

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SYBU Gene

Localization for SYBU Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYBU Gene

Isoform 1: Cytoplasm, cytoskeleton. Cytoplasmic vesicle. Note=Colocalizes with syntaxin vesicles along microtubules in neuronal processes.
Isoform 3: Golgi apparatus membrane; Single-pass membrane protein.
Isoform 4: Golgi apparatus membrane; Single-pass membrane protein.
Isoform 5: Golgi apparatus membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SYBU Gene COMPARTMENTS Subcellular localization image for SYBU gene
Compartment Confidence
cytoskeleton 5
golgi apparatus 5
cytosol 2
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SYBU Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005654 nucleoplasm IDA --
GO:0005739 mitochondrion IDA --
GO:0005794 Golgi apparatus --
GO:0005856 cytoskeleton --
genes like me logo Genes that share ontologies with SYBU: view

Pathways for SYBU Gene

SuperPathways for SYBU Gene

No Data Available

Gene Ontology (GO) - Biological Process for SYBU Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus IEA --
genes like me logo Genes that share ontologies with SYBU: view

No data available for Pathways by source for SYBU Gene

Transcripts for SYBU Gene

Unigene Clusters for SYBU Gene

Syntabulin (syntaxin-interacting):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SYBU

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SYBU

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SYBU Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d · 7e
SP1: - - - - -
SP2: - - - -
SP3: - - - - - - -
SP4: - - - - - - - -
SP5: - - - -
SP6:
SP7: - -
SP8: - - - - - - - -
SP9: - - -

Relevant External Links for SYBU Gene

GeneLoc Exon Structure for
SYBU
ECgene alternative splicing isoforms for
SYBU

Expression for SYBU Gene

mRNA expression in normal human tissues for SYBU Gene

mRNA differential expression in normal tissues according to GTEx for SYBU Gene

This gene is overexpressed in Pancreas (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SYBU Gene

SOURCE GeneReport for Unigene cluster for SYBU Gene Hs.390738

mRNA Expression by UniProt/SwissProt for SYBU Gene

Q9NX95-SYBU_HUMAN
Tissue specificity: Isoform 3, isoform 4 and isoform 5 are expressed in HeLa cell line (at protein level). Isoform 3 is expressed in fetal and adult brain. Isoform 4 is expressed in numerous fetal tissues (brain, kidney, liver, lung, and thymus) and in adult brain, kidney, liver, lung, pancreas, colon, prostate, small intestine, testis and thymus. Isoform 5 is expressed in fetal brain, brain and small intestine.
genes like me logo Genes that share expressions with SYBU: view

In Situ Assay Products

Orthologs for SYBU Gene

This gene was present in the common ancestor of chordates.

Orthologs for SYBU Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SYBU 35
  • 99.65 (n)
  • 99.4 (a)
SYBU 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SYBU 36
  • 69 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SYBU 35
  • 83.66 (n)
  • 83.21 (a)
SYBU 36
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sybu 35
  • 83.96 (n)
  • 85.78 (a)
Sybu 16
Sybu 36
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SYBU 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 65 (a)
OneToMany
-- 36
  • 50 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Sybu 35
  • 83.36 (n)
  • 86.84 (a)
chicken
(Gallus gallus)
Aves SYBU 35
  • 68.28 (n)
  • 66.26 (a)
SYBU 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SYBU 36
  • 59 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.8441 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.16935 35
sybu 35
  • 64.09 (n)
  • 63.16 (a)
zebrafish
(Danio rerio)
Actinopterygii sybu 35
  • 56.16 (n)
  • 50.17 (a)
sybu 36
  • 44 (a)
OneToOne
Species with no ortholog for SYBU:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SYBU Gene

ENSEMBL:
Gene Tree for SYBU (if available)
TreeFam:
Gene Tree for SYBU (if available)

Paralogs for SYBU Gene

Paralogs for SYBU Gene

genes like me logo Genes that share paralogs with SYBU: view

Variants for SYBU Gene

Sequence variations from dbSNP and Humsavar for SYBU Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs2702 -- 109,639,280(+) TAAAG(G/T)ATAAT intron-variant
rs1573853 -- 109,650,909(-) GAATA(G/T)GGATA intron-variant
rs1892758 -- 109,609,129(-) AGGAG(C/G)GGTTC intron-variant, upstream-variant-2KB
rs1892759 -- 109,604,765(-) AAAGA(C/T)CCAAG intron-variant, upstream-variant-2KB
rs1892760 -- 109,584,644(-) AAGTC(C/T)GCAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SYBU Gene

Variant ID Type Subtype PubMed ID
nsv519645 CNV Loss 19592680
esv275395 CNV Gain+Loss 21479260
esv993723 CNV Insertion 20482838
esv1058770 CNV Insertion 17803354
nsv396337 CNV Insertion 16902084
nsv398033 CNV Insertion 16902084

Relevant External Links for SYBU Gene

HapMap Linkage Disequilibrium report
SYBU

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SYBU Gene

Disorders for SYBU Gene

Relevant External Links for SYBU

Genetic Association Database (GAD)
SYBU
Human Genome Epidemiology (HuGE) Navigator
SYBU
genes like me logo Genes that share disorders with SYBU: view

No data available for UniProtKB/Swiss-Prot for SYBU Gene

Publications for SYBU Gene

  1. Syntabulin is a microtubule-associated protein implicated in syntaxin transport in neurons. (PMID: 15459722) Su Q. … Sheng Z.-H. (Nat. Cell Biol. 2004) 2 3 4
  2. Molecular cloning and characterization of gene for Golgi-localized syntaphilin-related protein on human chromosome 8q23. (PMID: 15656992) Funakoshi E. … Ito F. (Gene 2005) 2 3 4
  3. Syntabulin-mediated anterograde transport of mitochondria along neuronal processes. (PMID: 16157705) Cai Q. … Sheng Z.H. (J. Cell Biol. 2005) 2 3
  4. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for SYBU Gene

Sources for SYBU Gene

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