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Aliases for SYAP1 Gene

Aliases for SYAP1 Gene

  • Synapse Associated Protein 1 2 3
  • Synapse Associated Protein 1, SAP47 Homolog 3
  • SAP47 Homolog (Drosophila) 2
  • SAP47 Homolog 3
  • PRO3113 3

External Ids for SYAP1 Gene

Previous GeneCards Identifiers for SYAP1 Gene

  • GC0XP016468
  • GC0XP015563
  • GC0XP015939
  • GC0XP016099
  • GC0XP016497
  • GC0XP016647
  • GC0XP014492

Summaries for SYAP1 Gene

GeneCards Summary for SYAP1 Gene

SYAP1 (Synapse Associated Protein 1) is a Protein Coding gene. Among its related pathways are PI3K / Akt Signaling.

Gene Wiki entry for SYAP1 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYAP1 Gene

Genomics for SYAP1 Gene

Regulatory Elements for SYAP1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SYAP1 Gene

16,719,584 bp from pter
16,765,336 bp from pter
45,753 bases
Plus strand

Genomic View for SYAP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for SYAP1 Gene

Proteins for SYAP1 Gene

  • Protein details for SYAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Synapse-associated protein 1
    Protein Accession:
    Secondary Accessions:
    • Q68CP1
    • Q96C60
    • Q96JQ6
    • Q96T20

    Protein attributes for SYAP1 Gene

    352 amino acids
    Molecular mass:
    39933 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAK55531.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SYAP1 Gene

neXtProt entry for SYAP1 Gene

Proteomics data for SYAP1 Gene at MOPED

Post-translational modifications for SYAP1 Gene

  • Ubiquitination at Lys 194 and Lys 210
  • Glycosylation at Thr 79
  • Modification sites at PhosphoSitePlus

Other Protein References for SYAP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SYAP1 (SYAP1)

No data available for DME Specific Peptides for SYAP1 Gene

Domains & Families for SYAP1 Gene

Protein Domains for SYAP1 Gene


Suggested Antigen Peptide Sequences for SYAP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 BSD domain.
  • Contains 1 BSD domain.
genes like me logo Genes that share domains with SYAP1: view

No data available for Gene Families for SYAP1 Gene

Function for SYAP1 Gene

Phenotypes for SYAP1 Gene

MGI mutant phenotypes for SYAP1:
inferred from 1 alleles
GenomeRNAi human phenotypes for SYAP1:
genes like me logo Genes that share phenotypes with SYAP1: view

Animal Model Products

miRNA for SYAP1 Gene

miRTarBase miRNAs that target SYAP1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SYAP1

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for SYAP1 Gene

Localization for SYAP1 Gene

Subcellular locations from

Jensen Localization Image for SYAP1 Gene COMPARTMENTS Subcellular localization image for SYAP1 gene
Compartment Confidence
extracellular 5
golgi apparatus 4
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for SYAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005794 Golgi apparatus IDA --
GO:0070062 extracellular exosome IDA 18570454
genes like me logo Genes that share ontologies with SYAP1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SYAP1 Gene

Pathways & Interactions for SYAP1 Gene

SuperPathways for SYAP1 Gene

Superpath Contained pathways
1 PI3K / Akt Signaling
genes like me logo Genes that share pathways with SYAP1: view

Pathways by source for SYAP1 Gene

1 Cell Signaling Technology pathway for SYAP1 Gene

Interacting Proteins for SYAP1 Gene

Gene Ontology (GO) - Biological Process for SYAP1 Gene


No data available for SIGNOR curated interactions for SYAP1 Gene

Drugs & Compounds for SYAP1 Gene

No Compound Related Data Available

Transcripts for SYAP1 Gene

mRNA/cDNA for SYAP1 Gene

Unigene Clusters for SYAP1 Gene

Synapse associated protein 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SYAP1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SYAP1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b
SP3: -
SP4: - - - -

Relevant External Links for SYAP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SYAP1 Gene

mRNA expression in normal human tissues for SYAP1 Gene

Protein differential expression in normal tissues from HIPED for SYAP1 Gene

This gene is overexpressed in Adrenal (8.0), Oral epithelium (7.8), Heart (7.1), and Skin (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SYAP1 Gene

SOURCE GeneReport for Unigene cluster for SYAP1 Gene Hs.744256

genes like me logo Genes that share expression patterns with SYAP1: view

Protein tissue co-expression partners for SYAP1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SYAP1 Gene

Orthologs for SYAP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SYAP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SYAP1 35
  • 87.78 (n)
  • 87.78 (a)
SYAP1 36
  • 86 (a)
(Canis familiaris)
Mammalia SYAP1 35
  • 88.92 (n)
  • 90.62 (a)
SYAP1 36
  • 89 (a)
(Mus musculus)
Mammalia Syap1 35
  • 83.24 (n)
  • 85.14 (a)
Syap1 16
Syap1 36
  • 81 (a)
(Pan troglodytes)
Mammalia SYAP1 35
  • 99.81 (n)
  • 99.72 (a)
SYAP1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Syap1 35
  • 83.23 (n)
  • 86.45 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 76 (a)
-- 36
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia SYAP1 36
  • 68 (a)
(Gallus gallus)
Aves SYAP1 35
  • 77.14 (n)
  • 83 (a)
SYAP1 36
  • 79 (a)
(Anolis carolinensis)
Reptilia SYAP1 36
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75585 35
syap1 35
  • 72.12 (n)
  • 77.68 (a)
African clawed frog
(Xenopus laevis)
Amphibia syap1-prov 35
(Danio rerio)
Actinopterygii syap1 35
  • 68.38 (n)
  • 70.91 (a)
zgc56150 35
syap1 36
  • 69 (a)
fruit fly
(Drosophila melanogaster)
Insecta Sap47 37
  • 39 (a)
Sap47 35
  • 50.9 (n)
  • 44.4 (a)
Sap47 36
  • 19 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004273 35
  • 48.03 (n)
  • 37.06 (a)
(Caenorhabditis elegans)
Secernentea C16C2.4 36
  • 22 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2286 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 29 (a)
Species with no ortholog for SYAP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SYAP1 Gene

Gene Tree for SYAP1 (if available)
Gene Tree for SYAP1 (if available)

Paralogs for SYAP1 Gene

No data available for Paralogs for SYAP1 Gene

Variants for SYAP1 Gene

Sequence variations from dbSNP and Humsavar for SYAP1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs4330856 -- 16,727,420(+) ctcac(C/T)gcaac intron-variant
rs4342788 -- 16,735,019(+) AAAAA(A/C)AAACA intron-variant
rs4345743 -- 16,755,470(+) TTTTC(G/T)TTTTA intron-variant
rs4439299 -- 16,726,245(+) aatct(A/G)taact intron-variant
rs4487958 -- 16,734,779(+) TCATT(C/T)GAGGC intron-variant

Variation tolerance for SYAP1 Gene

Residual Variation Intolerance Score: 60.06% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.38; 8.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SYAP1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SYAP1 Gene

Disorders for SYAP1 Gene

Relevant External Links for SYAP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SYAP1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SYAP1 Gene

Publications for SYAP1 Gene

  1. Identification of novel proteins induced by estradiol, 4- hydroxytamoxifen and acolbifene in T47D breast cancer cells. (PMID: 16949628) Al-Dhaheri M.H. … Rowan B.G. (Steroids 2006) 23 67
  2. Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs. (PMID: 11483580) Yu Y. … He F. (Genome Res. 2001) 2 67
  3. [Cloning and characterization of syap1, a down regulated gene in human hepatocellular carcinoma]. (PMID: 12549212) Chang Y.C. … Xu Y.H. (Shi Yan Sheng Wu Xue Bao 2001) 23 67
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 67

Products for SYAP1 Gene

Sources for SYAP1 Gene

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