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Aliases for SYAP1 Gene

Aliases for SYAP1 Gene

  • Synapse Associated Protein 1 2 3 5
  • Synapse Associated Protein 1, SAP47 Homolog 3
  • Synapse-Associated Protein 1 3
  • SAP47 Homolog (Drosophila) 2
  • SAP47 Homolog 3
  • PRO3113 3

External Ids for SYAP1 Gene

Previous GeneCards Identifiers for SYAP1 Gene

  • GC0XP016468
  • GC0XP015563
  • GC0XP015939
  • GC0XP016099
  • GC0XP016497
  • GC0XP016647
  • GC0XP014492

Summaries for SYAP1 Gene

GeneCards Summary for SYAP1 Gene

SYAP1 (Synapse Associated Protein 1) is a Protein Coding gene. Among its related pathways are PI3K / Akt Signaling.

Gene Wiki entry for SYAP1 Gene

Additional gene information for SYAP1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYAP1 Gene

Genomics for SYAP1 Gene

GeneHancer (GH) Regulatory Elements for SYAP1 Gene

Promoters and enhancers for SYAP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI016718 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.5 530 2.8 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B SYAP1 RNU7-56P
GH0XI016483 Enhancer 0.2 FANTOM5 2.2 -236.0 -235979 0.2 SYAP1 LOC100132857 PIR48034 GC0XP016374
GH0XI016745 Enhancer 0.7 ENCODE 0.3 +26.3 26329 0.2 SOX13 FOXA2 SAP130 ARID4B ZNF384 RARA TEAD3 RERE NR2F6 CREM RNU7-56P SYAP1
GH0XI016722 Enhancer 0.4 ENCODE 0.4 +5.8 5793 6 HMBOX1 ZBTB33 SETDB1 RNU7-56P TXLNG RBBP7 SYAP1
GH0XI016743 Enhancer 0.5 ENCODE 0.3 +24.7 24663 1.2 ZNF121 CTCF RXRA HNF4A RAD21 RBBP7 RNU7-56P SYAP1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SYAP1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SYAP1 gene promoter:

Genomic Locations for SYAP1 Gene

Genomic Locations for SYAP1 Gene
chrX:16,719,584-16,765,336
(GRCh38/hg38)
Size:
45,753 bases
Orientation:
Plus strand
chrX:16,737,707-16,783,459
(GRCh37/hg19)

Genomic View for SYAP1 Gene

Genes around SYAP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SYAP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SYAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYAP1 Gene

Proteins for SYAP1 Gene

  • Protein details for SYAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96A49-SYAP1_HUMAN
    Recommended name:
    Synapse-associated protein 1
    Protein Accession:
    Q96A49
    Secondary Accessions:
    • Q68CP1
    • Q96C60
    • Q96JQ6
    • Q96T20

    Protein attributes for SYAP1 Gene

    Size:
    352 amino acids
    Molecular mass:
    39933 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAK55531.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SYAP1 Gene

neXtProt entry for SYAP1 Gene

Post-translational modifications for SYAP1 Gene

  • Ubiquitination at posLast=194194 and posLast=210210
  • Glycosylation at isoforms=79

Other Protein References for SYAP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SYAP1 Gene

Domains & Families for SYAP1 Gene

Gene Families for SYAP1 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for SYAP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SYAP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SYAP1: view

No data available for UniProtKB/Swiss-Prot for SYAP1 Gene

Function for SYAP1 Gene

Gene Ontology (GO) - Molecular Function for SYAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21044950
genes like me logo Genes that share ontologies with SYAP1: view

Phenotypes for SYAP1 Gene

MGI mutant phenotypes for SYAP1:
inferred from 2 alleles
GenomeRNAi human phenotypes for SYAP1:
genes like me logo Genes that share phenotypes with SYAP1: view

Animal Models for SYAP1 Gene

MGI Knock Outs for SYAP1:

Animal Model Products

miRNA for SYAP1 Gene

miRTarBase miRNAs that target SYAP1

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SYAP1 Gene

Localization for SYAP1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SYAP1 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
golgi apparatus 5
mitochondrion 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (4)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SYAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005794 Golgi apparatus IDA --
GO:0005829 cytosol IDA --
GO:0030424 axon ISS --
genes like me logo Genes that share ontologies with SYAP1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SYAP1 Gene

Pathways & Interactions for SYAP1 Gene

SuperPathways for SYAP1 Gene

SuperPathway Contained pathways
1 PI3K / Akt Signaling
genes like me logo Genes that share pathways with SYAP1: view

Pathways by source for SYAP1 Gene

1 Cell Signaling Technology pathway for SYAP1 Gene

Gene Ontology (GO) - Biological Process for SYAP1 Gene

None

No data available for SIGNOR curated interactions for SYAP1 Gene

Drugs & Compounds for SYAP1 Gene

No Compound Related Data Available

Transcripts for SYAP1 Gene

mRNA/cDNA for SYAP1 Gene

Unigene Clusters for SYAP1 Gene

Synapse associated protein 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SYAP1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b
SP1:
SP2:
SP3: -
SP4: - - - -
SP5:

Relevant External Links for SYAP1 Gene

GeneLoc Exon Structure for
SYAP1
ECgene alternative splicing isoforms for
SYAP1

Expression for SYAP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SYAP1 Gene

Protein differential expression in normal tissues from HIPED for SYAP1 Gene

This gene is overexpressed in Adrenal (8.0), Oral epithelium (7.8), Heart (7.1), and Skin (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SYAP1 Gene



Protein tissue co-expression partners for SYAP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of SYAP1 Gene:

SYAP1

SOURCE GeneReport for Unigene cluster for SYAP1 Gene:

Hs.744256

Evidence on tissue expression from TISSUES for SYAP1 Gene

  • Liver(4.6)
  • Blood(4.2)
  • Skin(4.2)
  • Nervous system(2.3)
genes like me logo Genes that share expression patterns with SYAP1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SYAP1 Gene

Orthologs for SYAP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SYAP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SYAP1 33 34
  • 99.81 (n)
dog
(Canis familiaris)
Mammalia SYAP1 33 34
  • 88.92 (n)
cow
(Bos Taurus)
Mammalia SYAP1 33 34
  • 87.78 (n)
mouse
(Mus musculus)
Mammalia Syap1 33 16 34
  • 83.24 (n)
rat
(Rattus norvegicus)
Mammalia Syap1 33
  • 83.23 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 81 (a)
OneToMany
-- 34
  • 76 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia SYAP1 34
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves SYAP1 33 34
  • 77.14 (n)
lizard
(Anolis carolinensis)
Reptilia SYAP1 34
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia syap1 33
  • 72.12 (n)
MGC75585 33
African clawed frog
(Xenopus laevis)
Amphibia syap1-prov 33
zebrafish
(Danio rerio)
Actinopterygii syap1 33 34
  • 68.38 (n)
zgc56150 33
fruit fly
(Drosophila melanogaster)
Insecta Sap47 35 33 34
  • 50.9 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004273 33
  • 48.03 (n)
worm
(Caenorhabditis elegans)
Secernentea C16C2.4 34
  • 22 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 29 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2286 33
Species where no ortholog for SYAP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SYAP1 Gene

ENSEMBL:
Gene Tree for SYAP1 (if available)
TreeFam:
Gene Tree for SYAP1 (if available)

Paralogs for SYAP1 Gene

No data available for Paralogs for SYAP1 Gene

Variants for SYAP1 Gene

Sequence variations from dbSNP and Humsavar for SYAP1 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000062367 -- 16,718,515(+) /C upstream_transcript_variant
rs1000273744 -- 16,756,330(+) T/A intron_variant
rs1000291529 -- 16,750,245(+) T/G intron_variant
rs1000324605 -- 16,750,491(+) G/C intron_variant
rs1000413728 -- 16,719,243(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SYAP1 Gene

Variant ID Type Subtype PubMed ID
esv3576787 CNV gain 25503493

Variation tolerance for SYAP1 Gene

Residual Variation Intolerance Score: 60.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.38; 8.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SYAP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SYAP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SYAP1 Gene

Disorders for SYAP1 Gene

Additional Disease Information for SYAP1

No disorders were found for SYAP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SYAP1 Gene

Publications for SYAP1 Gene

  1. Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs. (PMID: 11483580) Yu Y … He F (Genome research 2001) 2 3 4 58
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. [Cloning and characterization of syap1, a down regulated gene in human hepatocellular carcinoma]. (PMID: 12549212) Chang YC … Xu YH (Shi yan sheng wu xue bao 2001) 3 22 58

Products for SYAP1 Gene

Sources for SYAP1 Gene

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