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Aliases for SYAP1 Gene

Aliases for SYAP1 Gene

  • Synapse Associated Protein 1 2 3 5
  • Synapse Associated Protein 1, SAP47 Homolog 3
  • Synapse-Associated Protein 1 3
  • SAP47 Homolog (Drosophila) 2
  • SAP47 Homolog 3
  • PRO3113 3

External Ids for SYAP1 Gene

Previous GeneCards Identifiers for SYAP1 Gene

  • GC0XP016468
  • GC0XP015563
  • GC0XP015939
  • GC0XP016099
  • GC0XP016497
  • GC0XP016647
  • GC0XP014492

Summaries for SYAP1 Gene

GeneCards Summary for SYAP1 Gene

SYAP1 (Synapse Associated Protein 1) is a Protein Coding gene. Among its related pathways are PI3K / Akt Signaling.

Gene Wiki entry for SYAP1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYAP1 Gene

Genomics for SYAP1 Gene

Regulatory Elements for SYAP1 Gene

Enhancers for SYAP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XG016718 1.1 ENCODE 0.7 +0.5 531 2.8 HDGF PKNOX1 CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SYAP1 RNU7-56P
GH0XG016483 0.3 FANTOM5 2.2 -236.0 -235980 0.2 SYAP1 LOC100132857 PIR48034
GH0XG016722 0.8 ENCODE 0.4 +5.8 5794 6.0 ELF3 FOXA2 ARID4B RAD21 RARA ZNF121 CREM THAP11 MIXL1 TGIF2 RNU7-56P TXLNG RBBP7 SYAP1
GH0XG016745 0.8 ENCODE 0.3 +26.3 26329 0.2 SOX13 FOXA2 SAP130 ARID4B ZNF384 RARA TEAD3 RERE NR2F6 CREM RNU7-56P SYAP1
GH0XG016743 0.6 ENCODE 0.3 +24.7 24663 1.3 CTCF ZFP37 RAD21 ZNF121 ZNF664 ZNF24 HNF4A MAFK NFE2L2 RBBP7 RNU7-56P SYAP1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SYAP1 on UCSC Golden Path with GeneCards custom track

Promoters for SYAP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000244856 416 2001 HDGF PKNOX1 FOXA2 CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2

Genomic Location for SYAP1 Gene

Chromosome:
X
Start:
16,719,584 bp from pter
End:
16,765,336 bp from pter
Size:
45,753 bases
Orientation:
Plus strand

Genomic View for SYAP1 Gene

Genes around SYAP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SYAP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SYAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYAP1 Gene

Proteins for SYAP1 Gene

  • Protein details for SYAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96A49-SYAP1_HUMAN
    Recommended name:
    Synapse-associated protein 1
    Protein Accession:
    Q96A49
    Secondary Accessions:
    • Q68CP1
    • Q96C60
    • Q96JQ6
    • Q96T20

    Protein attributes for SYAP1 Gene

    Size:
    352 amino acids
    Molecular mass:
    39933 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAK55531.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SYAP1 Gene

neXtProt entry for SYAP1 Gene

Post-translational modifications for SYAP1 Gene

  • Ubiquitination at posLast=194194 and Lys210
  • Glycosylation at posLast=7979
  • Modification sites at PhosphoSitePlus

Other Protein References for SYAP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SYAP1 Gene

Domains & Families for SYAP1 Gene

Protein Domains for SYAP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SYAP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SYAP1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for SYAP1 Gene

Function for SYAP1 Gene

Gene Ontology (GO) - Molecular Function for SYAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21044950
genes like me logo Genes that share ontologies with SYAP1: view

Phenotypes for SYAP1 Gene

MGI mutant phenotypes for SYAP1:
inferred from 2 alleles
GenomeRNAi human phenotypes for SYAP1:
genes like me logo Genes that share phenotypes with SYAP1: view

Animal Models for SYAP1 Gene

MGI Knock Outs for SYAP1:

Animal Model Products

CRISPR Products

miRNA for SYAP1 Gene

miRTarBase miRNAs that target SYAP1

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SYAP1 Gene

Localization for SYAP1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SYAP1 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
golgi apparatus 5
mitochondrion 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for SYAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005794 Golgi apparatus IDA --
GO:0005829 cytosol IDA --
GO:0070062 extracellular exosome IDA 18570454
genes like me logo Genes that share ontologies with SYAP1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SYAP1 Gene

Pathways & Interactions for SYAP1 Gene

SuperPathways for SYAP1 Gene

SuperPathway Contained pathways
1 PI3K / Akt Signaling
genes like me logo Genes that share pathways with SYAP1: view

Pathways by source for SYAP1 Gene

1 Cell Signaling Technology pathway for SYAP1 Gene

Gene Ontology (GO) - Biological Process for SYAP1 Gene

None

No data available for SIGNOR curated interactions for SYAP1 Gene

Drugs & Compounds for SYAP1 Gene

No Compound Related Data Available

Transcripts for SYAP1 Gene

mRNA/cDNA for SYAP1 Gene

Unigene Clusters for SYAP1 Gene

Synapse associated protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SYAP1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b
SP1:
SP2:
SP3: -
SP4: - - - -
SP5:

Relevant External Links for SYAP1 Gene

GeneLoc Exon Structure for
SYAP1
ECgene alternative splicing isoforms for
SYAP1

Expression for SYAP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SYAP1 Gene

Protein differential expression in normal tissues from HIPED for SYAP1 Gene

This gene is overexpressed in Adrenal (8.0), Oral epithelium (7.8), Heart (7.1), and Skin (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SYAP1 Gene



Protein tissue co-expression partners for SYAP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of SYAP1 Gene:

SYAP1

SOURCE GeneReport for Unigene cluster for SYAP1 Gene:

Hs.744256

Evidence on tissue expression from TISSUES for SYAP1 Gene

  • Liver(4.6)
  • Blood(4.2)
  • Skin(4.2)
  • Nervous system(2.3)
genes like me logo Genes that share expression patterns with SYAP1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SYAP1 Gene

Orthologs for SYAP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SYAP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SYAP1 34 35
  • 99.81 (n)
dog
(Canis familiaris)
Mammalia SYAP1 34 35
  • 88.92 (n)
cow
(Bos Taurus)
Mammalia SYAP1 34 35
  • 87.78 (n)
mouse
(Mus musculus)
Mammalia Syap1 34 16 35
  • 83.24 (n)
rat
(Rattus norvegicus)
Mammalia Syap1 34
  • 83.23 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 81 (a)
OneToMany
-- 35
  • 76 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia SYAP1 35
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves SYAP1 34 35
  • 77.14 (n)
lizard
(Anolis carolinensis)
Reptilia SYAP1 35
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia syap1 34
  • 72.12 (n)
MGC75585 34
African clawed frog
(Xenopus laevis)
Amphibia syap1-prov 34
zebrafish
(Danio rerio)
Actinopterygii syap1 34 35
  • 68.38 (n)
zgc56150 34
fruit fly
(Drosophila melanogaster)
Insecta Sap47 36 34 35
  • 50.9 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004273 34
  • 48.03 (n)
worm
(Caenorhabditis elegans)
Secernentea C16C2.4 35
  • 22 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 29 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2286 34
Species where no ortholog for SYAP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SYAP1 Gene

ENSEMBL:
Gene Tree for SYAP1 (if available)
TreeFam:
Gene Tree for SYAP1 (if available)

Paralogs for SYAP1 Gene

No data available for Paralogs for SYAP1 Gene

Variants for SYAP1 Gene

Sequence variations from dbSNP and Humsavar for SYAP1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1000062367 -- 16,718,514(+) TTTTT(-/C)TTTTT upstream-variant-2KB
rs1000273744 -- 16,756,330(+) TATGA(A/T)GACAT intron-variant
rs1000291529 -- 16,750,245(+) CTCTT(G/T)TAGCA intron-variant
rs1000324605 -- 16,750,491(+) ACCCA(C/G)CATAG intron-variant
rs1000413728 -- 16,719,243(+) GCTTT(A/G)GGTTA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SYAP1 Gene

Variant ID Type Subtype PubMed ID
esv3576787 CNV gain 25503493

Variation tolerance for SYAP1 Gene

Residual Variation Intolerance Score: 60.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.38; 8.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SYAP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SYAP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SYAP1 Gene

Disorders for SYAP1 Gene

Relevant External Links for SYAP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SYAP1

No disorders were found for SYAP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SYAP1 Gene

Publications for SYAP1 Gene

  1. Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs. (PMID: 11483580) Yu Y. … He F. (Genome Res. 2001) 2 3 4 64
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. [Cloning and characterization of syap1, a down regulated gene in human hepatocellular carcinoma]. (PMID: 12549212) Chang Y.C. … Xu Y.H. (Shi Yan Sheng Wu Xue Bao 2001) 3 22 64

Products for SYAP1 Gene

Sources for SYAP1 Gene

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