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Aliases for SWT1 Gene

Aliases for SWT1 Gene

  • SWT1, RNA Endoribonuclease Homolog 2 3 5
  • C1orf26 3 4
  • SWT1 RNA Endoribonuclease Homolog (S. Cerevisiae) 2
  • Chromosome 1 Open Reading Frame 26 2
  • Transcriptional Protein SWT1 3
  • HsSwt1 3

External Ids for SWT1 Gene

Previous HGNC Symbols for SWT1 Gene

  • C1orf26

Summaries for SWT1 Gene

GeneCards Summary for SWT1 Gene

SWT1 (SWT1, RNA Endoribonuclease Homolog) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SWT1 Gene

Genomics for SWT1 Gene

Regulatory Elements for SWT1 Gene

Enhancers for SWT1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F185015 1.5 FANTOM5 Ensembl ENCODE 17.3 -140.3 -140314 3.2 PKNOX1 ZBTB40 RAD21 GATA2 SCRT2 FOS ZNF263 ZNF654 CEBPB REST SWT1 RNF2 TRMT1L FAM129A IVNS1ABP EDEM3 GC01M185014 RNA5SP72 GC01P185027
GH01F184415 1.6 FANTOM5 Ensembl ENCODE 10.3 -738.8 -738805 5.0 PKNOX1 ZNF133 SIN3A GLI4 ZNF2 ZNF121 GLIS2 ZNF416 KLF7 FOS SMG7-AS1 C1orf21 FTH1P25 ENSG00000252612 ENSG00000227554 LOC100422414 SWT1 COLGALT2 ENSG00000230470 GC01P184462
GH01F186081 1.6 FANTOM5 Ensembl ENCODE 10.3 +925.7 925745 2.0 PKNOX1 ATF1 ARNT FEZF1 CBX5 ELK1 GATA2 ZNF263 SP3 JUNB TPR OCLM LOC100422414 SWT1 HMCN1 PDC ENSG00000224691 GC01M185927
GH01F184385 1.4 FANTOM5 ENCODE 10.3 -768.9 -768915 4.6 PKNOX1 ZNF133 SIN3A FEZF1 GLI4 ZNF2 ZNF121 GLIS2 ZNF416 KLF7 SMG7-AS1 ENSG00000227554 FTH1P25 ENSG00000252612 LOC100422414 SWT1 EDEM3 C1orf21 ENSG00000230470
GH01F185373 1.5 FANTOM5 Ensembl ENCODE 8.8 +218.6 218558 4.4 SOX13 PKNOX1 SAP130 ETV1 JUN ZNF384 FOSL1 POLR2A NR2F6 CREM IVNS1ABP RNU7-183P FAM129A SWT1 LOC100422414 RNF2 EDEM3 TRMT1L LOC102724897
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SWT1 on UCSC Golden Path with GeneCards custom track

Promoters for SWT1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000671713 -23 3201 HDGF PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF143 FOS

Genomic Location for SWT1 Gene

Chromosome:
1
Start:
185,157,023 bp from pter
End:
185,291,781 bp from pter
Size:
134,759 bases
Orientation:
Plus strand

Genomic View for SWT1 Gene

Genes around SWT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SWT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SWT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SWT1 Gene

Proteins for SWT1 Gene

  • Protein details for SWT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T5J6-SWT1_HUMAN
    Recommended name:
    Transcriptional protein SWT1
    Protein Accession:
    Q5T5J6
    Secondary Accessions:
    • Q8NEK9
    • Q9BZQ7
    • Q9NXQ0

    Protein attributes for SWT1 Gene

    Size:
    900 amino acids
    Molecular mass:
    103222 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA90960.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for SWT1 Gene

Post-translational modifications for SWT1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SWT1 Gene

Domains & Families for SWT1 Gene

Protein Domains for SWT1 Gene

Suggested Antigen Peptide Sequences for SWT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5T5J6

UniProtKB/Swiss-Prot:

SWT1_HUMAN :
  • Contains 1 PINc domain.
  • Belongs to the SWT1 family.
Domain:
  • Contains 1 PINc domain.
Family:
  • Belongs to the SWT1 family.
genes like me logo Genes that share domains with SWT1: view

No data available for Gene Families for SWT1 Gene

Function for SWT1 Gene

genes like me logo Genes that share phenotypes with SWT1: view

Animal Model Products

miRNA for SWT1 Gene

miRTarBase miRNAs that target SWT1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SWT1 Gene

Localization for SWT1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SWT1 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for SWT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with SWT1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SWT1 Gene

Pathways & Interactions for SWT1 Gene

No Data Available

Interacting Proteins for SWT1 Gene

Gene Ontology (GO) - Biological Process for SWT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with SWT1: view

No data available for Pathways by source and SIGNOR curated interactions for SWT1 Gene

Transcripts for SWT1 Gene

Unigene Clusters for SWT1 Gene

SWT1 RNA endoribonuclease homolog (S. cerevisiae):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SWT1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b
SP1: -
SP2:
SP3: - -

Relevant External Links for SWT1 Gene

GeneLoc Exon Structure for
SWT1
ECgene alternative splicing isoforms for
SWT1

Expression for SWT1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SWT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SWT1 Gene

This gene is overexpressed in Testis (x5.9).

Protein differential expression in normal tissues from HIPED for SWT1 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SWT1 Gene



Protein tissue co-expression partners for SWT1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SWT1 Gene:

SWT1

SOURCE GeneReport for Unigene cluster for SWT1 Gene:

Hs.134183

mRNA Expression by UniProt/SwissProt for SWT1 Gene:

Q5T5J6-SWT1_HUMAN
Tissue specificity: Expressed weakly in testis.
genes like me logo Genes that share expression patterns with SWT1: view

Primer Products

Orthologs for SWT1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SWT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SWT1 34 35
  • 99.56 (n)
dog
(Canis familiaris)
Mammalia SWT1 34 35
  • 87.65 (n)
cow
(Bos Taurus)
Mammalia SWT1 34
  • 87.51 (n)
C16H1ORF26 35
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Swt1 34
  • 83.35 (n)
mouse
(Mus musculus)
Mammalia Swt1 34 16 35
  • 81.87 (n)
oppossum
(Monodelphis domestica)
Mammalia SWT1 35
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SWT1 35
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves SWT1 34 35
  • 59.97 (n)
lizard
(Anolis carolinensis)
Reptilia SWT1 35
  • 37 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii swt1 35
  • 26 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG7206 35
  • 23 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SWT1 37
Species where no ortholog for SWT1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SWT1 Gene

ENSEMBL:
Gene Tree for SWT1 (if available)
TreeFam:
Gene Tree for SWT1 (if available)

Paralogs for SWT1 Gene

No data available for Paralogs for SWT1 Gene

Variants for SWT1 Gene

Sequence variations from dbSNP and Humsavar for SWT1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10033300 -- 185,210,051(+) tcctt(C/T)gccca intron-variant
rs10047141 -- 185,175,522(+) tgcac(A/G)tggcc intron-variant
rs10218496 -- 185,237,252(+) cacac(A/G)tatgt intron-variant
rs10453829 -- 185,212,352(+) GTTGC(C/G)ATCTT intron-variant
rs10489579 -- 185,174,589(-) TTTAA(C/T)TCCAT nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for SWT1 Gene

Variant ID Type Subtype PubMed ID
esv3575349 CNV gain 25503493
nsv3855 CNV insertion 18451855
nsv521613 CNV loss 19592680
nsv548396 CNV loss 21841781
nsv548398 CNV gain 21841781
nsv946540 CNV duplication 23825009

Variation tolerance for SWT1 Gene

Residual Variation Intolerance Score: 66.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.51; 97.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SWT1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SWT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SWT1 Gene

Disorders for SWT1 Gene

Relevant External Links for SWT1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SWT1

No disorders were found for SWT1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SWT1 Gene

Publications for SWT1 Gene

  1. Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus. (PMID: 11318611) Sood R. … Carpten J.D. (Genomics 2001) 2 3 4 64
  2. Comprehensive analysis of the HEPN superfamily: identification of novel roles in intra-genomic conflicts, defense, pathogenesis and RNA processing. (PMID: 23768067) Anantharaman V. … Aravind L. (Biol. Direct 2013) 2 3 64
  3. An endoribonuclease functionally linked to perinuclear mRNP quality control associates with the nuclear pore complexes. (PMID: 19127978) SkruznA1 M. … Hurt E. (PLoS Biol. 2009) 2 3 64
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for SWT1 Gene

Sources for SWT1 Gene

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