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Aliases for SWT1 Gene

Aliases for SWT1 Gene

  • SWT1, RNA Endoribonuclease Homolog 2 3 5
  • C1orf26 3 4
  • SWT1 RNA Endoribonuclease Homolog (S. Cerevisiae) 2
  • Chromosome 1 Open Reading Frame 26 2
  • SWT1 RNA Endoribonuclease Homolog 3
  • HsSwt1 3

External Ids for SWT1 Gene

Previous HGNC Symbols for SWT1 Gene

  • C1orf26

Summaries for SWT1 Gene

GeneCards Summary for SWT1 Gene

SWT1 (SWT1, RNA Endoribonuclease Homolog) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SWT1 Gene

Genomics for SWT1 Gene

Regulatory Elements for SWT1 Gene

Enhancers for SWT1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SWT1 on UCSC Golden Path with GeneCards custom track

Promoters for SWT1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SWT1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SWT1 Gene

185,157,023 bp from pter
185,291,781 bp from pter
134,759 bases
Plus strand

Genomic View for SWT1 Gene

Genes around SWT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SWT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SWT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SWT1 Gene

Proteins for SWT1 Gene

  • Protein details for SWT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transcriptional protein SWT1
    Protein Accession:
    Secondary Accessions:
    • Q8NEK9
    • Q9BZQ7
    • Q9NXQ0

    Protein attributes for SWT1 Gene

    900 amino acids
    Molecular mass:
    103222 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA90960.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for SWT1 Gene

Proteomics data for SWT1 Gene at MOPED

Post-translational modifications for SWT1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SWT1 Gene

No data available for DME Specific Peptides for SWT1 Gene

Domains & Families for SWT1 Gene

Protein Domains for SWT1 Gene

Suggested Antigen Peptide Sequences for SWT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 PINc domain.
  • Belongs to the SWT1 family.
  • Contains 1 PINc domain.
  • Belongs to the SWT1 family.
genes like me logo Genes that share domains with SWT1: view

No data available for Gene Families for SWT1 Gene

Function for SWT1 Gene

genes like me logo Genes that share phenotypes with SWT1: view

Animal Model Products

miRNA for SWT1 Gene

miRTarBase miRNAs that target SWT1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SWT1 Gene

Localization for SWT1 Gene

Subcellular locations from

Jensen Localization Image for SWT1 Gene COMPARTMENTS Subcellular localization image for SWT1 gene
Compartment Confidence
nucleus 4
cytosol 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SWT1 Gene

Pathways & Interactions for SWT1 Gene

SuperPathways for SWT1 Gene

No Data Available

Interacting Proteins for SWT1 Gene

Gene Ontology (GO) - Biological Process for SWT1 Gene


No data available for Pathways by source and SIGNOR curated interactions for SWT1 Gene

Drugs & Compounds for SWT1 Gene

No Compound Related Data Available

Transcripts for SWT1 Gene

Unigene Clusters for SWT1 Gene

SWT1 RNA endoribonuclease homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SWT1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b
SP1: -
SP3: - -

Relevant External Links for SWT1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SWT1 Gene

mRNA expression in normal human tissues for SWT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SWT1 Gene

This gene is overexpressed in Testis (x5.9).

Protein differential expression in normal tissues from HIPED for SWT1 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SWT1 Gene

SOURCE GeneReport for Unigene cluster for SWT1 Gene Hs.134183

mRNA Expression by UniProt/SwissProt for SWT1 Gene

Tissue specificity: Expressed weakly in testis.
genes like me logo Genes that share expression patterns with SWT1: view

Protein tissue co-expression partners for SWT1 Gene

- Elite partner

Primer Products

Orthologs for SWT1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SWT1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SWT1 35
  • 87.51 (n)
  • 80.09 (a)
C16H1ORF26 36
  • 78 (a)
(Canis familiaris)
Mammalia SWT1 35
  • 87.65 (n)
  • 81.14 (a)
SWT1 36
  • 79 (a)
(Mus musculus)
Mammalia Swt1 35
  • 81.87 (n)
  • 71.9 (a)
Swt1 16
Swt1 36
  • 70 (a)
(Pan troglodytes)
Mammalia SWT1 35
  • 99.56 (n)
  • 99.11 (a)
SWT1 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Swt1 35
  • 83.35 (n)
  • 74.97 (a)
(Monodelphis domestica)
Mammalia SWT1 36
  • 59 (a)
(Ornithorhynchus anatinus)
Mammalia SWT1 36
  • 56 (a)
(Gallus gallus)
Aves SWT1 35
  • 59.97 (n)
  • 47.57 (a)
SWT1 36
  • 40 (a)
(Anolis carolinensis)
Reptilia SWT1 36
  • 37 (a)
(Danio rerio)
Actinopterygii swt1 36
  • 26 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7206 36
  • 23 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SWT1 38
Species with no ortholog for SWT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SWT1 Gene

Gene Tree for SWT1 (if available)
Gene Tree for SWT1 (if available)

Paralogs for SWT1 Gene

No data available for Paralogs for SWT1 Gene

Variants for SWT1 Gene

Sequence variations from dbSNP and Humsavar for SWT1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10489579 - 185,174,589(-) TTTAA(C/T)TCCAT nc-transcript-variant, reference, missense
rs6698109 - 185,202,737(+) ATTAC(A/G)CTTAT nc-transcript-variant, reference, missense
rs2295950 - 185,206,705(+) GGATT(A/C)GTTAT nc-transcript-variant, reference, missense
VAR_027655 -
rs883753 -- 185,261,718(+) TTGGG(G/T)TAGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SWT1 Gene

Variant ID Type Subtype PubMed ID
nsv521613 CNV Loss 19592680
nsv3855 CNV Insertion 18451855

Variation tolerance for SWT1 Gene

Residual Variation Intolerance Score: 66.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.51; 97.19% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SWT1 Gene

Disorders for SWT1 Gene

Relevant External Links for SWT1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SWT1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SWT1 Gene

Publications for SWT1 Gene

  1. Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus. (PMID: 11318611) Sood R. … Carpten J.D. (Genomics 2001) 2 3 4 67
  2. Comprehensive analysis of the HEPN superfamily: identification of novel roles in intra-genomic conflicts, defense, pathogenesis and RNA processing. (PMID: 23768067) Anantharaman V. … Aravind L. (Biol. Direct 2013) 2 3
  3. An endoribonuclease functionally linked to perinuclear mRNP quality control associates with the nuclear pore complexes. (PMID: 19127978) SkruznA1 M. … Hurt E. (PLoS Biol. 2009) 2 3
  4. Replication of previous genome-wide association studies of bone mineral density in premenopausal American women. (PMID: 20200978) Ichikawa S. … Econs M.J. (J. Bone Miner. Res. 2010) 3
  5. New genetic associations detected in a host response study to hepatitis B vaccine. (PMID: 20237496) Davila S. … Seielstad M. (Genes Immun. 2010) 3

Products for SWT1 Gene

Sources for SWT1 Gene