SWT1 Gene
protein-coding GIFtS: 41
GCID: GC01P185127
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SWT1 RNA endoribonuclease homolog (S. cerevisiae)(Previous name: chromosome 1 open reading frame 26 )
(Previous symbol: C1orf26)
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Aliases
for SWT1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| SWT1 RNA Endoribonuclease Homolog (S. Cerevisiae)1 2 | | C1orf261 2 3 | | HsSwt11 2 | | FLJ201211 | | Chromosome 1 Open Reading Frame 261 | | Transcriptional Protein SWT12 |
Export aliases for SWT1 gene to outside databases |
Summaries
for SWT1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for SWT1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for SWT1
Other transcription factors
Search SABiosciences Chromatin IP Primers for SWT1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SWT1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q25 Ensembl cytogenetic band: 1q25.3 HGNC cytogenetic band: 1q25SWT1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P185127: view genomic region
(about GC identifiers)
Start:
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185,126,192 bp from pter |
End:
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185,260,913 bp from pter |
Size:
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134,722 bases |
Orientation:
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plus strand |
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Proteins
for SWT1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SWT1_HUMAN, Q5T5J6 (See
protein sequence)Recommended Name: Transcriptional protein SWT1 Size: 900 amino acids; 103222 Da
Sequence caution: Sequence=BAA90960.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q8NEK9 Q9BZQ7 Q9NXQ0Explore the universe of human proteins at neXtProt for SWT1: NX_Q5T5J6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5T5J6
SWT1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001098988.1 NP_060143.4
ENSEMBL proteins: ENSP00000356471 ENSP00000356470 ENSP00000401413
Human Recombinant Protein Products:
SWT1 Antibody Products:
Assay Products for SWT1: |
Protein
Domains /
Families
for SWT1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SWT1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q5T5J6ProtoNet protein and cluster: Q5T5J6 1 Blocks protein family: IPB006596 Nucleotide binding protein
UniProtKB/Swiss-Prot: SWT1_HUMAN, Q5T5J6Similarity: Belongs to the SWT1 familySimilarity: Contains 1 PINc domain |
Function
for SWT1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SWT1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SWT1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): SWT1 (NM_017673) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SWT1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SWT1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SWT1 |
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Pathways & Interactions
for SWT1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SWT1
|
Drugs & Compounds
for SWT1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SWT1
Search CenterWatch for drugs/clinical trials and news about SWT1
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Transcripts
for SWT1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SWT1 gene (2 alternative transcripts): NM_001105518.1 NM_017673.6 Unigene Cluster for SWT1: SWT1 RNA endoribonuclease homolog (S. cerevisiae) Hs.134183 [show with all ESTs]Unigene Representative Sequence: NM_0176733 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000367501 ENST00000367500(uc001grg.4 uc001grh.4) ENST00000450350
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SWT1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SWT1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): SWT1 (NM_017673) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SWT1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SWT1 |
Additional cDNA sequence: AF288392.1 AK000128.1 AK093263.1 AK124353.1 AK127980.1 AK225238.1 AK291443.1 AK315802.1 BC030781.2 7 DOTS entries: DT.112969 DT.121326811 DT.121326846 DT.100653443 DT.100746740 DT.121326828 DT.95165923 24/76 AceView cDNA sequences (see all 76): AW662329 CD628464 AA010695 CD723865 D55590 AA010694 R22876 BE221876 C00491 AI804490 BM769470 BE466543 AL705541 BM769850 AK000128 BM830728 AW197088 AF288392 W16957 AA399027 AI825651 BI756018 AI703135 BX956390
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for SWT1 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20a | · | 20b |
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| SP1: | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SWT1
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Expression
for SWT1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SWT1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGACCTGAT
About this image
See SWT1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SWT1
SOURCE GeneReport for Unigene cluster: Hs.134183
UniProtKB/Swiss-Prot: SWT1_HUMAN, Q5T5J6Tissue specificity: Expressed weakly in testis
SABiosciences Custom PCR Arrays for SWT1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SWT1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SWT1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SWT1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SWT1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SWT1 |
Orthologs
for SWT1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of animals.
Orthologs for SWT1 gene from 5/17 species (see all 17) About this table
ENSEMBL Gene Tree for SWT1 (if available)
TreeFam Gene Tree for SWT1 (if available) |
Paralogs
for SWT1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for SWT1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for SWT1 (185126192 - 185260913 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SWT1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SWT1 |
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Disorders
/ Diseases
for SWT1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SWT1 for disorders About GeneDecksing
4  diseases for SWT1: About MalaCardshepatitis b prostate cancer hepatitis prostatitis
Export disorders for SWT1 gene to outside databases
|
Publications
for SWT1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SWT1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SWT1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus. (PubMed id 11318611)1, 2, 3 Sood R....Carpten J.D. (2001)
- An endoribonuclease functionally linked to perinuclea r mRNP quality control associates with the nuclear pore complexes. (PubMed id 19127978)1, 3 SkruznA1 M....Hurt E. (2009)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (2010)
- Replication of previous genome-wide association studi es of bone mineral density in premenopausal American women. (PubMed id 20200978)1 Ichikawa S....Econs M.J. (2010)
- Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)1 Trynka G....Wijmenga C. (2009)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (1994)
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External Searches for SWT1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing SWT1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SWT1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SWT1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SWT1 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for SWT1 gene:
Search GeneIP for patents involving SWT1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SWT1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SWT1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SWT1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SWT1 | | | OriGene Protein Over-expression Lysate for SWT1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SWT1 | | OriGene 3'-UTR Clone for SWT1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SWT1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SWT1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SWT1 | | OriGene Custom Protein Services for SWT1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SWT1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SWT1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SWT1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SWT1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SWT1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SWT1 |
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| | | | Search Tocris compounds for SWT1 |
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 | | | SWT1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SWT1 |
|  |  |  | | | | ThermoFisher Antibodies for SWT1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SWT1 |
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