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Aliases for SWSAP1 Gene

Aliases for SWSAP1 Gene

  • SWIM-Type Zinc Finger 7 Associated Protein 1 2 3 5
  • SWS1-Associated Protein 1 2 3 4
  • SWIM-Type Zinc Finger 7-Associated Protein 1 3 4
  • ZSWIM7-Associated Protein 1 3 4
  • ZSWIM7AP1 3 4
  • C19orf39 3 4
  • Zinc Finger, SWIM-Type Containing 7 Associated Protein 1 3
  • SWIM-Type Containing 7 Associated Protein 1 2
  • Chromosome 19 Open Reading Frame 39 2
  • Zinc Finger 2
  • SWS1AP1 3

External Ids for SWSAP1 Gene

Previous HGNC Symbols for SWSAP1 Gene

  • C19orf39

Previous GeneCards Identifiers for SWSAP1 Gene

  • GC19P011486

Summaries for SWSAP1 Gene

GeneCards Summary for SWSAP1 Gene

SWSAP1 (SWIM-Type Zinc Finger 7 Associated Protein 1) is a Protein Coding gene. GO annotations related to this gene include ATPase activity and single-stranded DNA binding.

UniProtKB/Swiss-Prot for SWSAP1 Gene

  • ATPase which is preferentially stimulated by single-stranded DNA and is involved in homologous recombination repair (HRR). Has a DNA-binding activity which is independent of its ATPase activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SWSAP1 Gene

Genomics for SWSAP1 Gene

Regulatory Elements for SWSAP1 Gene

Promoters for SWSAP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SWSAP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SWSAP1 Gene

Chromosome:
19
Start:
11,374,685 bp from pter
End:
11,376,951 bp from pter
Size:
2,267 bases
Orientation:
Plus strand

Genomic View for SWSAP1 Gene

Genes around SWSAP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SWSAP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SWSAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SWSAP1 Gene

Proteins for SWSAP1 Gene

  • Protein details for SWSAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6NVH7-SWAP1_HUMAN
    Recommended name:
    ATPase SWSAP1
    Protein Accession:
    Q6NVH7
    Secondary Accessions:
    • Q8NAM1

    Protein attributes for SWSAP1 Gene

    Size:
    229 amino acids
    Molecular mass:
    24311 Da
    Quaternary structure:
    • Interacts with ZSWIM7; they form a functional complex involved in homologous recombination repair and stabilize each other. Interacts with RAD51, RAD51B, RAD51C, RAD51D and XRCC3; involved in homologous recombination repair.

neXtProt entry for SWSAP1 Gene

Proteomics data for SWSAP1 Gene at MOPED

Post-translational modifications for SWSAP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SWSAP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SWSAP1 Gene

Domains & Families for SWSAP1 Gene

Protein Domains for SWSAP1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SWSAP1: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for SWSAP1 Gene

Function for SWSAP1 Gene

Molecular function for SWSAP1 Gene

UniProtKB/Swiss-Prot Function:
ATPase which is preferentially stimulated by single-stranded DNA and is involved in homologous recombination repair (HRR). Has a DNA-binding activity which is independent of its ATPase activity.

Gene Ontology (GO) - Molecular Function for SWSAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003697 single-stranded DNA binding IDA 21965664
GO:0005515 protein binding IPI 21965664
genes like me logo Genes that share ontologies with SWSAP1: view
genes like me logo Genes that share phenotypes with SWSAP1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SWSAP1 Gene

Localization for SWSAP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SWSAP1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SWSAP1 Gene COMPARTMENTS Subcellular localization image for SWSAP1 gene
Compartment Confidence
nucleus 4
extracellular 2
mitochondrion 2
cytosol 1

No data available for Gene Ontology (GO) - Cellular Components for SWSAP1 Gene

Pathways & Interactions for SWSAP1 Gene

SuperPathways for SWSAP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SWSAP1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SWSAP1 Gene

Drugs & Compounds for SWSAP1 Gene

No Compound Related Data Available

Transcripts for SWSAP1 Gene

mRNA/cDNA for SWSAP1 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(53) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SWSAP1 Gene

SWIM-type zinc finger 7 associated protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SWSAP1 Gene

No ASD Table

Relevant External Links for SWSAP1 Gene

GeneLoc Exon Structure for
SWSAP1
ECgene alternative splicing isoforms for
SWSAP1

Expression for SWSAP1 Gene

mRNA expression in normal human tissues for SWSAP1 Gene

SOURCE GeneReport for Unigene cluster for SWSAP1 Gene Hs.631619

genes like me logo Genes that share expression patterns with SWSAP1: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SWSAP1 Gene

Orthologs for SWSAP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SWSAP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SWSAP1 35
  • 83.64 (n)
  • 81.31 (a)
SWSAP1 36
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SWSAP1 35
  • 84.59 (n)
  • 82.55 (a)
SWSAP1 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Swsap1 35
  • 72.99 (n)
  • 71.09 (a)
Swsap1 16
Swsap1 36
  • 55 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SWSAP1 35
  • 99.42 (n)
  • 99.56 (a)
SWSAP1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Swsap1 35
  • 76.38 (n)
  • 74.17 (a)
oppossum
(Monodelphis domestica)
Mammalia SWSAP1 36
  • 45 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SWSAP1 36
  • 41 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SWSAP1 36
  • 36 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii swsap1 36
  • 22 (a)
OneToOne
Species with no ortholog for SWSAP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SWSAP1 Gene

ENSEMBL:
Gene Tree for SWSAP1 (if available)
TreeFam:
Gene Tree for SWSAP1 (if available)

Paralogs for SWSAP1 Gene

No data available for Paralogs for SWSAP1 Gene

Variants for SWSAP1 Gene

Sequence variations from dbSNP and Humsavar for SWSAP1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs317926 - 11,375,838(+) GCCAG(A/G)TGCAC reference, missense
rs316503 -- 11,374,576(+) ACAGA(C/T)TCCTA upstream-variant-2KB
rs11542550 -- 11,375,788(-) GCCAG(A/G)TGCAG reference, synonymous-codon
rs34156839 -- 11,374,876(+) GGCCT(A/C/T)TTCAA reference, missense
rs34651602 -- 11,374,461(+) CTGGT(C/T)CCCCC upstream-variant-2KB

Variation tolerance for SWSAP1 Gene

Residual Variation Intolerance Score: 40.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.70; 46.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SWSAP1 Gene

HapMap Linkage Disequilibrium report
SWSAP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SWSAP1 Gene

Disorders for SWSAP1 Gene

Relevant External Links for SWSAP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SWSAP1

No disorders were found for SWSAP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SWSAP1 Gene

Publications for SWSAP1 Gene

  1. hSWS1.SWSAP1 is an evolutionarily conserved complex required for efficient homologous recombination repair. (PMID: 21965664) Liu T. … Huang J. (J. Biol. Chem. 2011) 2 3 4 67
  2. Evolutionary and functional analysis of the invariant SWIM domain in the conserved Shu2/SWS1 protein family from Saccharomyces cerevisiae to Homo sapiens. (PMID: 25659377) Godin S.K. … Bernstein K.A. (Genetics 2015) 3
  3. Interactome mapping suggests new mechanistic details underlying Alzheimer's disease. (PMID: 21163940) Soler-LA^pez M. … Aloy P. (Genome Res. 2011) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for SWSAP1 Gene

Sources for SWSAP1 Gene

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