SWSAP1 Gene
protein-coding GIFtS: 37
GCID: GC19P011486
|
|
SWIM-type zinc finger 7 associated protein 1(Previous name: chromosome 19 open reading frame 39 )
(Previous symbol: C19orf39)
| |
Aliases
for SWSAP1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| SWIM-Type Zinc Finger 7 Associated Protein 11 2 | | ZSWIM7-Associated Protein 12 3 | | C19orf391 2 3 | | FLJ351191 | | ZSWIM7AP11 2 3 | | Chromosome 19 Open Reading Frame 391 | | SWS1AP11 2 | | ATPase SWSAP12 | | SWIM-Type Zinc Finger 7-Associated Protein 12 3 | | Zinc Finger, SWIM-Type Containing 7 Associated Protein 12 | | SWS1-Associated Protein 12 3 | | |
Export aliases for SWSAP1 gene to outside databases |
Summaries
for SWSAP1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: SWAP1_HUMAN, Q6NVH7Function: ATPase which is preferentially stimulated by single-stranded DNA and is involved in homologous recombinationrepair (HRR). Has a DNA-binding activity which is independent of its ATPase activity
|
Genomic Views
for SWSAP1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011295.11
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for SWSAP1
Other transcription factors
Search SABiosciences Chromatin IP Primers for SWSAP1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SWSAP1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.2 Ensembl cytogenetic band: 19p13.2 HGNC cytogenetic band: 19p13.2SWSAP1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P011486: view genomic region
(about GC identifiers)
Start:
|
11,485,361 bp from pter |
End:
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11,487,627 bp from pter |
Size:
|
2,267 bases |
Orientation:
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plus strand |
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Proteins
for SWSAP1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SWAP1_HUMAN, Q6NVH7 (See
protein sequence)Recommended Name: ATPase SWSAP1 Size: 229 amino acids; 24311 Da
Subunit: Interacts with ZSWIM7; they form a functional complex involved in homologous recombination repair andstabilize each other. Interacts with RAD51, RAD51B, RAD51C, RAD51D and XRCC3; involved in homologous recombinationrepair
Subcellular location: Nucleus (Probable)
Secondary accessions: Q8NAM1Explore the universe of human proteins at neXtProt for SWSAP1: NX_Q6NVH7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6NVH7
SWSAP1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_787067.2
ENSEMBL proteins: ENSP00000310008
Human Recombinant Protein Products for SWSAP1:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
SWSAP1 for ontologies About GeneDecksing
SWSAP1 Antibody Products:
Assay Products for SWSAP1: |
Protein
Domains /
Families
for SWSAP1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q6NVH7 |
Function
for SWSAP1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: SWAP1_HUMAN, Q6NVH7Function: ATPase which is preferentially stimulated by single-stranded DNA and is involved in homologous recombinationrepair (HRR). Has a DNA-binding activity which is independent of its ATPase activity Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
SWSAP1 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SWSAP1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SWSAP1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for SWSAP1 | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SWSAP1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SWSAP1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SWSAP1 |
|
Pathways & Interactions
for SWSAP1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SWSAP1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 6)
5/7 Interacting proteins for SWSAP1 (Q6NVH71 ENSP000003100084) via UniProtKB, MINT, STRING, and/or I2D (see all 7)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| XRCC3 | O435421, ENSP000003433924 | EBI-5281637,EBI-2849976 STRING: ENSP00000343392 | | RAD51D | O757711, ENSP000003780904 | EBI-5281637,EBI-1055693 STRING: ENSP00000378090 | | RAD51 | Q066091, ENSP000002678684 | EBI-5281637,EBI-1059207 STRING: ENSP00000267868 | | RAD51C | O435021, ENSP000003367014 | EBI-5281637,EBI-2267048 STRING: ENSP00000336701 | | ZSWIM7 | Q19AV61, ENSP000003822184 | EBI-5281637,EBI-5281647 STRING: ENSP00000382218 |
About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000724 | double-strand break repair via homologous recombination |
IMP | -- | | GO:0006200 | ATP catabolic process |
IDA | -- | | GO:0050821 | protein stabilization |
IMP | -- |
SWSAP1 for ontologies About GeneDecksing
|
Drugs & Compounds
for SWSAP1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SWSAP1
Search CenterWatch for drugs/clinical trials and news about SWSAP1 / SWAP1
|
Transcripts
for SWSAP1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SWSAP1 gene: NM_175871.3 Unigene Cluster for SWSAP1: SWIM-type zinc finger 7 associated protein 1 Hs.631619 [show with all ESTs]Unigene Representative Sequence: NM_1758711 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000312423(uc002mrg.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SWSAP1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SWSAP1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for SWSAP1 | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SWSAP1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SWSAP1 |
Additional cDNA sequence: AK092438.1 BC068071.1 BC119677.2 3 DOTS entries: DT.405470 DT.95262016 DT.91663610 24/53 AceView cDNA sequences (see all 53): AI382116 BM918827 BC068071 AI745355 CF541010 BM712144 CA449500 AW452372 BQ011347 BU677559 CA412949 AL045438 BM670208 AI341600 AI871573 AI192241 AA878367 CD518817 CF528967 AI244444 BM795028 AI806078 AK092438 AI743019
GeneLoc Exon Structure
|
Expression
for SWSAP1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SWSAP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCTGGAATAC
About this image
See SWSAP1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SWSAP1
SOURCE GeneReport for Unigene cluster: Hs.631619
SABiosciences Custom PCR Arrays for SWSAP1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SWSAP1
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat SWSAP1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SWSAP1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SWSAP1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SWSAP1 |
Orthologs
for SWSAP1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for SWSAP1 gene from 3/9 species (see all 9) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Swsap11 , 5 |
RIKEN cDNA 2310047B19 gene5
SWIM type zinc finger 7 associated protein 11 |
71.28(n)1
69.2(a)1 |
|
9 (7.93 cM)5
669621 NM_025870.11 NP_080146.11
219557535 |
lizard
(Anolis carolinensis) |
Reptilia |
C19orf396 |
-- |
41(a) |
1 ↔ 1 |
2(79017581-79019326) |
zebrafish
(Danio rerio) |
Actinopterygii |
swsap16 |
SWIM-type zinc finger 7 associated protein 1 |
21(a) |
1 ↔ 1 |
3(14170454-14176207) |
ENSEMBL Gene Tree for SWSAP1 (if available)
TreeFam Gene Tree for SWSAP1 (if available) |
Paralogs
for SWSAP1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for SWSAP1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SWSAP1 (11485361 - 11487627 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SWSAP1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SWSAP1 |
|
Disorders
/ Diseases
for SWSAP1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 SWSAP1 for disorders About MalaCards
SWSAP1 for disorders About GeneDecksing
OMIM gene information: 614536
OMIM disorders: --
Export disorders for SWSAP1 gene to outside databases
|
Publications
for SWSAP1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SWSAP1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SWSAP1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- hSWS1.SWSAP1 is an evolutionarily conserved complex required for efficient homologous recombination repair. (PubMed id 21965664)1, 2, 3 Liu T.... Huang J. (2011)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Interactome mapping suggests new mechanistic details u nderlying Alzheimer's disease. (PubMed id 21163940)1 Soler-Lopez M....Aloy P. (2011)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for SWSAP1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SWSAP1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SWSAP1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SWSAP1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SWSAP1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SWSAP1 gene:
Search GeneIP for patents involving SWSAP1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SWSAP1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SWSAP1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SWSAP1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SWSAP1 | | | OriGene Protein Over-expression Lysate for SWSAP1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SWSAP1 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SWSAP1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SWSAP1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SWSAP1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SWSAP1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SWSAP1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SWSAP1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SWSAP1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SWSAP1 |
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 |  |  |  | |
| | | | Search Tocris compounds for SWSAP1 |
| |  |  |  |  | | | | |
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 |
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 | | | SWSAP1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SWSAP1 |
|  |  |  |  | | | | ThermoFisher Antibodies for SWSAP1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SWSAP1 |
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