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Aliases for SWI5 Gene

Aliases for SWI5 Gene

  • SWI5 Homologous Recombination Repair Protein 2 3 5
  • HBV DNAPTP1-Transactivated Protein A 3 4
  • Protein SAE3 Homolog 3 4
  • C9orf119 3 4
  • SAE3 3 4
  • SWI5 Recombination Repair Homolog (Yeast) 2
  • Chromosome 9 Open Reading Frame 119 2
  • SWI5 Recombination Repair Homolog 3

External Ids for SWI5 Gene

Previous HGNC Symbols for SWI5 Gene

  • C9orf119

Previous GeneCards Identifiers for SWI5 Gene

  • GC09P131038
  • GC09P131039
  • GC09P131041
  • GC09P131044
  • GC09P131059

Summaries for SWI5 Gene

GeneCards Summary for SWI5 Gene

SWI5 (SWI5 Homologous Recombination Repair Protein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SWI5 Gene

  • Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SWI5 Gene

Genomics for SWI5 Gene

Genomic Location for SWI5 Gene

Chromosome:
9
Start:
128,275,379 bp from pter
End:
128,288,990 bp from pter
Size:
13,612 bases
Orientation:
Plus strand

Genomic View for SWI5 Gene

Genes around SWI5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SWI5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SWI5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SWI5 Gene

No data available for Regulatory Elements for SWI5 Gene

Proteins for SWI5 Gene

  • Protein details for SWI5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q1ZZU3-SWI5_HUMAN
    Recommended name:
    DNA repair protein SWI5 homolog
    Protein Accession:
    Q1ZZU3
    Secondary Accessions:
    • Q5SYX7
    • Q5SYX8
    • Q8N2W6

    Protein attributes for SWI5 Gene

    Size:
    235 amino acids
    Molecular mass:
    26739 Da
    Quaternary structure:
    • Component of the SWI5-SFR1 complex. Interacts with RAD51.
    SequenceCaution:
    • Sequence=CAI13840.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI13843.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI13844.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for SWI5 Gene

Proteomics data for SWI5 Gene at MOPED

Post-translational modifications for SWI5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SWI5 Gene

Domains & Families for SWI5 Gene

Protein Domains for SWI5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SWI5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q1ZZU3

UniProtKB/Swiss-Prot:

SWI5_HUMAN :
  • Belongs to the SWI5/SAE3 family.
Family:
  • Belongs to the SWI5/SAE3 family.
genes like me logo Genes that share domains with SWI5: view

No data available for Gene Families for SWI5 Gene

Function for SWI5 Gene

Molecular function for SWI5 Gene

UniProtKB/Swiss-Prot Function:
Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination.

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SWI5 Gene

Localization for SWI5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SWI5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SWI5 Gene COMPARTMENTS Subcellular localization image for SWI5 gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 2

Gene Ontology (GO) - Cellular Components for SWI5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032798 Swi5-Sfr1 complex IEA,IDA 21252223
genes like me logo Genes that share ontologies with SWI5: view

Pathways & Interactions for SWI5 Gene

SuperPathways for SWI5 Gene

No Data Available

Interacting Proteins for SWI5 Gene

Gene Ontology (GO) - Biological Process for SWI5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0071479 cellular response to ionizing radiation IDA 23754376
genes like me logo Genes that share ontologies with SWI5: view

No data available for Pathways by source and SIGNOR curated interactions for SWI5 Gene

Drugs & Compounds for SWI5 Gene

No Compound Related Data Available

Transcripts for SWI5 Gene

Unigene Clusters for SWI5 Gene

SWI5 recombination repair homolog (yeast):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SWI5 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b
SP1: -
SP2: - -
SP3:

Relevant External Links for SWI5 Gene

GeneLoc Exon Structure for
SWI5
ECgene alternative splicing isoforms for
SWI5

Expression for SWI5 Gene

mRNA expression in normal human tissues for SWI5 Gene

mRNA differential expression in normal tissues according to GTEx for SWI5 Gene

This gene is overexpressed in Testis (x4.9).

SOURCE GeneReport for Unigene cluster for SWI5 Gene Hs.259594

genes like me logo Genes that share expression patterns with SWI5: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SWI5 Gene

Orthologs for SWI5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SWI5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SWI5 36
  • 100 (a)
OneToOne
SWI5 35
  • 99.15 (n)
  • 99.57 (a)
cow
(Bos Taurus)
Mammalia SWI5 35
  • 81.82 (n)
  • 75.15 (a)
SWI5 36
  • 69 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SWI5 36
  • 61 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Swi5 36
  • 67 (a)
OneToOne
Swi5 16
Swi5 35
  • 77.52 (n)
  • 70.93 (a)
oppossum
(Monodelphis domestica)
Mammalia SWI5 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SWI5 36
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Swi5 35
  • 79.46 (n)
  • 70.93 (a)
lizard
(Anolis carolinensis)
Reptilia SWI5 36
  • 65 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.33205 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1722 35
swi5 35
  • 61.49 (n)
  • 55.34 (a)
zebrafish
(Danio rerio)
Actinopterygii swi5 36
  • 36 (a)
OneToOne
Species with no ortholog for SWI5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SWI5 Gene

ENSEMBL:
Gene Tree for SWI5 (if available)
TreeFam:
Gene Tree for SWI5 (if available)

Paralogs for SWI5 Gene

Pseudogenes.org Pseudogenes for SWI5 Gene

genes like me logo Genes that share paralogs with SWI5: view

No data available for Paralogs for SWI5 Gene

Variants for SWI5 Gene

Sequence variations from dbSNP and Humsavar for SWI5 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs2286816 -- 128,288,975(-) AGATA(C/T)GTTTA downstream-variant-500B, utr-variant-3-prime
rs7047845 -- 128,278,934(+) tgccc(A/G)gctaa intron-variant
rs7864839 -- 128,288,899(+) GGGGC(A/G)TTCCC downstream-variant-500B, utr-variant-3-prime
rs11306272 -- 128,281,057(+) TTTTT(-/T)GAGAG intron-variant
rs35243211 -- 128,285,379(+) GCTCA(A/G)GCTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SWI5 Gene

Variant ID Type Subtype PubMed ID
dgv8294n71 CNV Loss 21882294
nsv831728 CNV Loss 17160897

Variation tolerance for SWI5 Gene

Gene Damage Index Score: 4.54; 64.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SWI5 Gene

HapMap Linkage Disequilibrium report
SWI5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SWI5 Gene

Disorders for SWI5 Gene

Relevant External Links for SWI5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SWI5

No disorders were found for SWI5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SWI5 Gene

Publications for SWI5 Gene

  1. The role of human SWI5-MEI5 complex in homologous recombination repair. (PMID: 21252223) Yuan J. … Chen J. (J. Biol. Chem. 2011) 2 3 4 67
  2. Role for the mammalian Swi5-Sfr1 complex in DNA strand break repair through homologous recombination. (PMID: 20976249) Akamatsu Y. … Jasin M. (PLoS Genet. 2010) 2 3
  3. FIGNL1-containing protein complex is required for efficient homologous recombination repair. (PMID: 23754376) Yuan J. … Chen J. (Proc. Natl. Acad. Sci. U.S.A. 2013) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3

Products for SWI5 Gene

Sources for SWI5 Gene

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