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Aliases for SWI5 Gene

Aliases for SWI5 Gene

  • SWI5 Homologous Recombination Repair Protein 2 3 5
  • HBV DNAPTP1-Transactivated Protein A 3 4
  • Protein SAE3 Homolog 3 4
  • C9orf119 3 4
  • SAE3 3 4
  • SWI5 Recombination Repair Homolog (Yeast) 2
  • Chromosome 9 Open Reading Frame 119 2
  • SWI5 Recombination Repair Homolog 3
  • DNA Repair Protein SWI5 Homolog 3

External Ids for SWI5 Gene

Previous HGNC Symbols for SWI5 Gene

  • C9orf119

Previous GeneCards Identifiers for SWI5 Gene

  • GC09P131038
  • GC09P131039
  • GC09P131041
  • GC09P131044
  • GC09P131059

Summaries for SWI5 Gene

GeneCards Summary for SWI5 Gene

SWI5 (SWI5 Homologous Recombination Repair Protein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SWI5 Gene

  • Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination.

Additional gene information for SWI5 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SWI5 Gene

Genomics for SWI5 Gene

GeneHancer (GH) Regulatory Elements for SWI5 Gene

Promoters and enhancers for SWI5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I128274 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 556.1 +0.5 536 3 HDGF PKNOX1 SMAD1 ARID4B SIN3A DMAP1 YY1 ZNF143 KLF13 SP3 SWI5 GOLGA2 SNORA65 SLC27A4 FPGS LOC102723566 RPL12 URM1 ZNF79
GH09I128837 Enhancer 0.9 ENCODE 20.9 +563.0 562989 1.3 FOXA2 ZNF493 ZFP64 ARID4B ZNF48 GLIS2 ZNF213 ZNF202 SP5 ZC3H11A NUP188 SPOUT1 ODF2 GOLGA2 CIZ1 URM1 GLE1 NAIF1 LOC101929314 SWI5
GH09I127387 Enhancer 1.5 Ensembl ENCODE dbSUPER 12.2 -886.1 -886062 4.4 PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 IRF4 ZNF213 SNORA65 RPL12 ZNF79 SWI5 NAIF1 CDK9 ENSG00000228487 GARNL3 SLC2A8 GOLGA2
GH09I127761 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 5.1 -508.5 -508545 11.3 HDGF PKNOX1 ATF1 ARNT ARID4B SIN3A ZBTB7B YY1 TCF12 ZNF121 SH2D3C FPGS ENG LOC102723566 AK1 ST6GALNAC6 ST6GALNAC4 PIP5KL1 FAM129B SWI5
GH09I128241 Enhancer 1.3 FANTOM5 Ensembl ENCODE 4.6 -31.1 -31053 5.7 HDAC1 ELF3 HDGF PKNOX1 ATF1 NFXL1 DNMT3B GLIS2 EGR1 ARID2 MIR199B MIR3154 GLE1 NUP188 NAIF1 URM1 SLC27A4 PHYHD1 SWI5 ST6GALNAC6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SWI5 on UCSC Golden Path with GeneCards custom track

Genomic Locations for SWI5 Gene

Genomic Locations for SWI5 Gene
chr9:128,275,379-128,288,990
(GRCh38/hg38)
Size:
13,612 bases
Orientation:
Plus strand
chr9:131,037,658-131,051,269
(GRCh37/hg19)

Genomic View for SWI5 Gene

Genes around SWI5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SWI5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SWI5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SWI5 Gene

Proteins for SWI5 Gene

  • Protein details for SWI5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q1ZZU3-SWI5_HUMAN
    Recommended name:
    DNA repair protein SWI5 homolog
    Protein Accession:
    Q1ZZU3
    Secondary Accessions:
    • Q5SYX7
    • Q5SYX8
    • Q8N2W6

    Protein attributes for SWI5 Gene

    Size:
    235 amino acids
    Molecular mass:
    26739 Da
    Quaternary structure:
    • Component of the SWI5-SFR1 complex. Interacts with RAD51.
    SequenceCaution:
    • Sequence=CAI13840.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI13843.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI13844.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for SWI5 Gene

Post-translational modifications for SWI5 Gene

No Post-translational modifications

No data available for DME Specific Peptides for SWI5 Gene

Domains & Families for SWI5 Gene

Gene Families for SWI5 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SWI5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SWI5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q1ZZU3

UniProtKB/Swiss-Prot:

SWI5_HUMAN :
  • Belongs to the SWI5/SAE3 family.
Family:
  • Belongs to the SWI5/SAE3 family.
genes like me logo Genes that share domains with SWI5: view

Function for SWI5 Gene

Molecular function for SWI5 Gene

UniProtKB/Swiss-Prot Function:
Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination.

Phenotypes From GWAS Catalog for SWI5 Gene

Gene Ontology (GO) - Molecular Function for SWI5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21252223
genes like me logo Genes that share ontologies with SWI5: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SWI5 Gene

Localization for SWI5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SWI5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SWI5 gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SWI5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0032798 Swi5-Sfr1 complex IDA 21252223
genes like me logo Genes that share ontologies with SWI5: view

Pathways & Interactions for SWI5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SWI5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000724 double-strand break repair via homologous recombination IMP 21252223
GO:0000730 DNA recombinase assembly IBA --
GO:0006281 DNA repair IEA --
GO:0006974 cellular response to DNA damage stimulus IEA --
GO:0071479 cellular response to ionizing radiation IDA 23754376
genes like me logo Genes that share ontologies with SWI5: view

No data available for Pathways by source and SIGNOR curated interactions for SWI5 Gene

Drugs & Compounds for SWI5 Gene

No Compound Related Data Available

Transcripts for SWI5 Gene

Unigene Clusters for SWI5 Gene

SWI5 recombination repair homolog (yeast):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SWI5 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b
SP1: -
SP2: - -
SP3:

Relevant External Links for SWI5 Gene

GeneLoc Exon Structure for
SWI5
ECgene alternative splicing isoforms for
SWI5

Expression for SWI5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SWI5 Gene

mRNA differential expression in normal tissues according to GTEx for SWI5 Gene

This gene is overexpressed in Testis (x4.9).

NURSA nuclear receptor signaling pathways regulating expression of SWI5 Gene:

SWI5

SOURCE GeneReport for Unigene cluster for SWI5 Gene:

Hs.259594

Evidence on tissue expression from TISSUES for SWI5 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with SWI5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SWI5 Gene

Orthologs for SWI5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SWI5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SWI5 33 34
  • 99.15 (n)
cow
(Bos Taurus)
Mammalia SWI5 33 34
  • 81.82 (n)
rat
(Rattus norvegicus)
Mammalia Swi5 33
  • 79.46 (n)
oppossum
(Monodelphis domestica)
Mammalia SWI5 34
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Swi5 33 16 34
  • 77.52 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SWI5 34
  • 71 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SWI5 34
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SWI5 34
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia swi5 33
  • 61.49 (n)
Str.1722 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.33205 33
zebrafish
(Danio rerio)
Actinopterygii swi5 34
  • 36 (a)
OneToOne
Species where no ortholog for SWI5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SWI5 Gene

ENSEMBL:
Gene Tree for SWI5 (if available)
TreeFam:
Gene Tree for SWI5 (if available)

Paralogs for SWI5 Gene

Pseudogenes.org Pseudogenes for SWI5 Gene

genes like me logo Genes that share paralogs with SWI5: view

No data available for Paralogs for SWI5 Gene

Variants for SWI5 Gene

Sequence variations from dbSNP and Humsavar for SWI5 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000116511 -- 128,286,227(+) G/A intron_variant
rs1000328117 -- 128,280,600(+) C/T intron_variant
rs1000329079 -- 128,274,335(+) G/A upstream_transcript_variant
rs1000371851 -- 128,283,148(+) C/T intron_variant
rs1000425640 -- 128,274,686(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SWI5 Gene

Variant ID Type Subtype PubMed ID
nsv831728 CNV loss 17160897
nsv972808 CNV duplication 23825009

Variation tolerance for SWI5 Gene

Gene Damage Index Score: 4.54; 64.87% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SWI5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SWI5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SWI5 Gene

Disorders for SWI5 Gene

Additional Disease Information for SWI5

No disorders were found for SWI5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SWI5 Gene

Publications for SWI5 Gene

  1. The role of the human SWI5-MEI5 complex in homologous recombination repair. (PMID: 21252223) Yuan J … Chen J (The Journal of biological chemistry 2011) 2 3 4 58
  2. FIGNL1-containing protein complex is required for efficient homologous recombination repair. (PMID: 23754376) Yuan J … Chen J (Proceedings of the National Academy of Sciences of the United States of America 2013) 3 4 58
  3. Role for the mammalian Swi5-Sfr1 complex in DNA strand break repair through homologous recombination. (PMID: 20976249) Akamatsu Y … Jasin M (PLoS genetics 2010) 2 3 58
  4. Downregulation of SWI5 and CTC1 genes: hepatitis B virus DNA polymerase transactivated protein 1-mediated inhibition of DNA repair. (PMID: 27265469) Yao XK … Sui W (Acta virologica 2016) 3 58
  5. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 4 58

Products for SWI5 Gene

Sources for SWI5 Gene

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