SWI5 Gene
protein-coding GIFtS: 35
GCID: GC09P131041
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SWI5 recombination repair homolog (yeast)(Previous name: chromosome 9 open reading frame 119 )
(Previous symbol: C9orf119)
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Aliases
for SWI5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| SWI5 Recombination Repair Homolog (Yeast)1 2 | | HBV DNAPTP1-Transactivated Protein A2 3 | | C9orf1191 2 3 | | Chromosome 9 Open Reading Frame 1191 | | BA395P17.91 | | DNA Repair Protein SWI5 Homolog2 | | Protein SAE3 Homolog2 3 | | SAE33 |
Export aliases for SWI5 gene to outside databasesPrevious GC identifers: GC09P131038 GC09P131039 |
Summaries
for SWI5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: SWI5_HUMAN, Q1ZZU3Function: Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologousrecombination
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Genomic Views
for SWI5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008470.19
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for SWI5
Other transcription factors
Search SABiosciences Chromatin IP Primers for SWI5
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SWI5 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q34.11 Ensembl cytogenetic band: 9q34.11 HGNC cytogenetic band: 9q34.13SWI5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09P131041: view genomic region
(about GC identifiers)
Start:
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131,037,658 bp from pter |
End:
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131,051,269 bp from pter |
Size:
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13,612 bases |
Orientation:
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plus strand |
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Proteins
for SWI5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SWI5_HUMAN, Q1ZZU3 (See
protein sequence)Recommended Name: DNA repair protein SWI5 homolog Size: 235 amino acids; 26739 Da
Subunit: Component of the SWI5-SFR1 complex. Interacts with RAD51
Subcellular location: Nucleus (By similarity)
Sequence caution: Sequence=CAI13840.1; Type=Erroneous gene model prediction; Sequence=CAI13843.1; Type=Erroneousinitiation; Note=Translation N-terminally extended; Sequence=CAI13844.1; Type=Erroneous gene model prediction;
Secondary accessions: Q5SYX7 Q5SYX8 Q8N2W6Explore the universe of human proteins at neXtProt for SWI5: NX_Q1ZZU3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q1ZZU3
SWI5 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001035100.1
ENSEMBL proteins: ENSP00000419719 ENSP00000361989 ENSP00000316609 ENSP00000411469
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
SWI5 for ontologies About GeneDecksing
SWI5 Antibody Products:
Assay Products for SWI5: |
Protein
Domains /
Families
for SWI5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SWI5 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q1ZZU3ProtoNet protein and cluster: Q1ZZU3 UniProtKB/Swiss-Prot: SWI5_HUMAN, Q1ZZU3Similarity: Belongs to the SWI5/SAE3 family |
Function
for SWI5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SWI5_HUMAN, Q1ZZU3Function: Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologousrecombination
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SWI5 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SWI5
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for SWI5 | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SWI5 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SWI5 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SWI5 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
IPI | -- |
SWI5 for ontologies About GeneDecksing
|
Pathways & Interactions
for SWI5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SWI5
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for SWI5 (ENSP000003166094) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000724 | double-strand break repair via homologous recombination |
IMP | -- |
SWI5 for ontologies About GeneDecksing
|
Drugs & Compounds
for SWI5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SWI5
Search CenterWatch for drugs/clinical trials and news about SWI5
|
Transcripts
for SWI5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SWI5 gene: NM_001040011.1 Unigene Cluster for SWI5: SWI5 recombination repair homolog (yeast) Hs.259594 [show with all ESTs]Unigene Representative Sequence: BU5025975 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000495313 ENST00000372898 ENST00000320188(uc004bup.3) ENST00000419867(uc010mxx.1)
ENST00000418976
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SWI5 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SWI5
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for SWI5 | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SWI5 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SWI5 |
Additional cDNA sequence: AK311408.1 BC029911.1 DQ414820.1 8 DOTS entries: DT.91709622 DT.100755109 DT.211884 DT.91759938 DT.100670445 DT.91759937 DT.95110274 DT.95368338 24/97 AceView cDNA sequences (see all 97): BC029911 CB161208 BU731468 AA041356 AI073907 BM835301 BF516360 AW148808 CB154255 AI262198 AI911723 CK300124 CD678061 CB124669 BE207254 BM764620 BU502470 BE041791 BG656389 AA864210 BM194674 BF718615 BU502597 AI243897
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for SWI5 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b |
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| SP1: | | | | | | | | | | | | | - | | | | | | |
| SP2: | | | | | - | | | | | | | | - | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SWI5
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Expression
for SWI5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SWI5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TACTTTATTT
About this image
See SWI5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SWI5
SOURCE GeneReport for Unigene cluster: Hs.259594
SABiosciences Custom PCR Arrays for SWI5
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SWI5
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat SWI5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SWI5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SWI5 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SWI5 |
Orthologs
for SWI5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for SWI5 gene from 6/14 species (see all 14) About this table
ENSEMBL Gene Tree for SWI5 (if available)
TreeFam Gene Tree for SWI5 (if available) |
Paralogs
for SWI5 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SWI5 gene
SWI5 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for SWI5
PGOHUM00000246840
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Genomic Variants
for SWI5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SWI5 (131037658 - 131051269 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SWI5: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SWI5 |
|
Disorders
/ Diseases
for SWI5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for SWI5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SWI5 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SWI5) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The role of human SWI5-MEI5 complex in homologous recombination repair. (PubMed id 21252223)1, 2, 3 Yuan J. and Chen J. (2011)
- Role for the mammalian Swi5-Sfr1 complex in DNA stran d break repair through homologous recombination. (PubMed id 20976249)1, 3 Akamatsu Y. and Jasin M. (2010)
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)2 Humphray S.J.... Dunham I. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
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External Searches for SWI5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing SWI5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SWI5 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SWI5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SWI5 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SWI5 gene:
Search GeneIP for patents involving SWI5
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SWI5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SWI5 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SWI5 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SWI5 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SWI5 | | OriGene 3'-UTR Clone for SWI5 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SWI5 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SWI5 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SWI5 | | OriGene Custom Protein Services for SWI5 | | | OriGene Custom Immunoassay Development | | |
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 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SWI5 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SWI5 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SWI5 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SWI5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SWI5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SWI5 |
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 |  |  |  | |
| | | | Search Tocris compounds for SWI5 |
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 | | | SWI5 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SWI5 |
|  |  |  | | | | Search ThermoFisher Antibodies for SWI5 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SWI5 |
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