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Aliases for SWI5 Gene

Aliases for SWI5 Gene

  • SWI5 Recombination Repair Homolog (Yeast) 2 3
  • HBV DNAPTP1-Transactivated Protein A 3 4
  • Protein SAE3 Homolog 3 4
  • C9orf119 3 4
  • Chromosome 9 Open Reading Frame 119 2
  • DNA Repair Protein SWI5 Homolog 3
  • BA395P17.9 3
  • SAE3 4

External Ids for SWI5 Gene

Previous HGNC Symbols for SWI5 Gene

  • C9orf119

Previous GeneCards Identifiers for SWI5 Gene

  • GC09P131038
  • GC09P131039
  • GC09P131041
  • GC09P131044
  • GC09P131059

Summaries for SWI5 Gene

GeneCards Summary for SWI5 Gene

SWI5 (SWI5 Recombination Repair Homolog (Yeast)) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SWI5 Gene

  • Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SWI5 Gene

Genomics for SWI5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SWI5 Gene

Start:
128,275,379 bp from pter
End:
128,288,990 bp from pter
Size:
13,612 bases
Orientation:
Plus strand

Genomic View for SWI5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SWI5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SWI5 Gene

No data available for Regulatory Elements for SWI5 Gene

Proteins for SWI5 Gene

  • Protein details for SWI5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q1ZZU3-SWI5_HUMAN
    Recommended name:
    DNA repair protein SWI5 homolog
    Protein Accession:
    Q1ZZU3
    Secondary Accessions:
    • Q5SYX7
    • Q5SYX8
    • Q8N2W6

    Protein attributes for SWI5 Gene

    Size:
    235 amino acids
    Molecular mass:
    26739 Da
    Quaternary structure:
    • Component of the SWI5-SFR1 complex. Interacts with RAD51.
    SequenceCaution:
    • Sequence=CAI13840.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI13843.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI13844.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for SWI5 Gene

Proteomics data for SWI5 Gene at MOPED

Post-translational modifications for SWI5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SWI5 Gene

No data available for DME Specific Peptides for SWI5 Gene

Domains for SWI5 Gene

Protein Domains for SWI5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SWI5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q1ZZU3

UniProtKB/Swiss-Prot:

SWI5_HUMAN :
  • Q1ZZU3
Family:
  • Belongs to the SWI5/SAE3 family.
genes like me logo Genes that share domains with SWI5: view

No data available for Gene Families for SWI5 Gene

Function for SWI5 Gene

Molecular function for SWI5 Gene

UniProtKB/Swiss-Prot Function: Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination.

Gene Ontology (GO) - Molecular Function for SWI5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21252223
genes like me logo Genes that share ontologies with SWI5: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SWI5 Gene

Localization for SWI5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SWI5 Gene

Gene Ontology (GO) - Cellular Components for SWI5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0032798 Swi5-Sfr1 complex IDA 21252223
genes like me logo Genes that share ontologies with SWI5: view

No data available for Subcellular locations from COMPARTMENTS for SWI5 Gene

Pathways for SWI5 Gene

SuperPathways for SWI5 Gene

No Data Available

Interacting Proteins for SWI5 Gene

Gene Ontology (GO) - Biological Process for SWI5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000724 double-strand break repair via homologous recombination IMP 21252223
GO:0071479 cellular response to ionizing radiation IDA 23754376
genes like me logo Genes that share ontologies with SWI5: view

No data available for Pathways by source for SWI5 Gene

Transcripts for SWI5 Gene

Unigene Clusters for SWI5 Gene

SWI5 recombination repair homolog (yeast):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SWI5

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SWI5
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SWI5 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b
SP1: -
SP2: - -
SP3:

Relevant External Links for SWI5 Gene

GeneLoc Exon Structure for
SWI5
ECgene alternative splicing isoforms for
SWI5

Expression for SWI5 Gene

mRNA expression in normal human tissues for SWI5 Gene

mRNA differential expression in normal tissues according to GTEx for SWI5 Gene

This gene is overexpressed in Testis (4.9).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SWI5 Gene

SOURCE GeneReport for Unigene cluster for SWI5 Gene Hs.259594

genes like me logo Genes that share expressions with SWI5: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for SWI5 Gene

Orthologs for SWI5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SWI5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SWI5 35
  • 99.15 (n)
  • 99.57 (a)
SWI5 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SWI5 35
  • 81.82 (n)
  • 75.15 (a)
SWI5 36
  • 69 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SWI5 36
  • 61 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Swi5 35
  • 77.52 (n)
  • 70.93 (a)
Swi5 16
Swi5 36
  • 67 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SWI5 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SWI5 36
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Swi5 35
  • 79.46 (n)
  • 70.93 (a)
lizard
(Anolis carolinensis)
Reptilia SWI5 36
  • 65 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.33205 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1722 35
swi5 35
  • 61.49 (n)
  • 55.34 (a)
zebrafish
(Danio rerio)
Actinopterygii swi5 36
  • 36 (a)
OneToOne
Species with no ortholog for SWI5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SWI5 Gene

ENSEMBL:
Gene Tree for SWI5 (if available)
TreeFam:
Gene Tree for SWI5 (if available)

Paralogs for SWI5 Gene

Pseudogenes.org Pseudogenes for SWI5 Gene

genes like me logo Genes that share paralogs with SWI5: view

No data available for Paralogs for SWI5 Gene

Variants for SWI5 Gene

Sequence variations from dbSNP and Humsavar for SWI5 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs1053673 -- 128,288,876(+) GAGAA(A/G)AGGCG utr-variant-3-prime
rs2240956 -- 128,286,481(-) GACAT(A/G)CAGGT intron-variant
rs2240958 -- 128,282,905(-) CCACC(A/G)TGCCC intron-variant
rs2270204 -- 128,280,455(-) AGAGC(A/C)CACTT intron-variant
rs2286816 -- 128,288,975(-) AGATA(C/T)GTTTA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SWI5 Gene

Variant ID Type Subtype PubMed ID
dgv8294n71 CNV Loss 21882294
nsv831728 CNV Loss 17160897

Relevant External Links for SWI5 Gene

HapMap Linkage Disequilibrium report
SWI5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SWI5 Gene

Disorders for SWI5 Gene

No disorders were found for SWI5 Gene.

No data available for UniProtKB/Swiss-Prot for SWI5 Gene

Publications for SWI5 Gene

  1. The role of human SWI5-MEI5 complex in homologous recombination repair. (PMID: 21252223) Yuan J. … Chen J. (J. Biol. Chem. 2011) 2 3 4
  2. FIGNL1-containing protein complex is required for efficient homologous recombination repair. (PMID: 23754376) Yuan J. … Chen J. (Proc. Natl. Acad. Sci. U.S.A. 2013) 3 4
  3. Role for the mammalian Swi5-Sfr1 complex in DNA strand break repair through homologous recombination. (PMID: 20976249) Akamatsu Y. … Jasin M. (PLoS Genet. 2010) 2 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 4

Products for SWI5 Gene

Sources for SWI5 Gene

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