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SWAP70 Gene

protein-coding   GIFtS: 58
GCID: GC11P009685

SWAP Switching B-Cell Complex 70kDa Subunit

  See SWAP70-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SWAP Switching B-Cell Complex 70kDa Subunit1 2
SWAP-702 3
Switch-Associated Protein 702
KIAA06403

External Ids:    HGNC: 170701   Entrez Gene: 230752   Ensembl: ENSG000001337897   OMIM: 6047625   UniProtKB: Q9UH653   

Export aliases for SWAP70 gene to outside databases

Previous GC identifers: GC11P010697 GC11P010255 GC11P009724 GC11P009649 GC11P009642 GC11P009358


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SWAP70 Gene:
SWAP70 (SWAP switching B-cell complex 70kDa subunit) is a protein-coding gene. Diseases associated with SWAP70 include x-linked hyper igm syndrome, and nodular lymphocyte predominant hodgkin lymphoma. GO annotations related to this gene include phospholipid binding and calcium ion binding. An important paralog of this gene is DEF6.

UniProtKB/Swiss-Prot: SWP70_HUMAN, Q9UH65
Function: Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which,
independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of
membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist
stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion (By similarity)

Gene Wiki entry for SWAP70 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_009237.19  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SWAP70 gene promoter:
         AREB6   RP58   POU2F1   POU2F1b   POU2F1a   ARP-1   POU2F1c   XBP-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSWAP70 promoter sequence
   Search Chromatin IP Primers for SWAP70

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SWAP70


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15

SWAP70 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SWAP70 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P009685:  view genomic region     (about GC identifiers)

Start:
9,685,624 bp from pter      End:
9,774,538 bp from pter
Size:
88,915 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SWP70_HUMAN, Q9UH65 (See protein sequence)
Recommended Name: Switch-associated protein 70  
Size: 585 amino acids; 68998 Da
Subunit: The SWAP complex consists of NPM1, NCL, PARP1 and SWAP70 (By similarity)
Sequence caution: Sequence=AAF28999.1; Type=Frameshift; Positions=480, 483; Sequence=BAA31615.1; Type=Erroneous
initiation;
1 PDB 3D structure from and Proteopedia for SWAP70:
2DN6 (3D)    
Secondary accessions: D3DQV1 O75135 Q7LCY6 Q9P061 Q9P0Z8

Explore the universe of human proteins at neXtProt for SWAP70: NX_Q9UH65

Explore proteomics data for SWAP70 at MOPED

Post-translational modifications: 

  • Tyrosine-phosphorylated1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SWAP70 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055870.2  
    ENSEMBL proteins: 
     ENSP00000399056   ENSP00000315630   ENSP00000431768   ENSP00000435587   ENSP00000433824  

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    Cloud-Clone Corp. Proteins for SWAP70

     
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    antibodies-online proteins for SWAP70 (5 products) 

     
    antibodies-online peptides for SWAP70

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PLEKH: Pleckstrin homology (PH) domain containing
    EFHAND: EF-hand domain containing

    3 InterPro protein domains:
     IPR002048 EF_hand_dom
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom

    Graphical View of Domain Structure for InterPro Entry Q9UH65

    ProtoNet protein and cluster: Q9UH65

    1 Blocks protein domain: IPB001849 Pleckstrin-like

    UniProtKB/Swiss-Prot: SWP70_HUMAN, Q9UH65
    Domain: The PH domain is essential for phosphatidylinositol 3,4,5-trisphosphate binding
    Similarity: Contains 1 PH domain


    Find genes that share domains with SWAP70           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SWP70_HUMAN, Q9UH65
    Function: Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which,
    independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of
    membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist
    stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion (By similarity)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding ----
    GO:0005524ATP binding IEA--
         
    Find genes that share ontologies with SWAP70           About GenesLikeMe


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Swap70):
     cellular  hematopoietic system  immune system 

    Find genes that share phenotypes with SWAP70           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Swap70tm1Jess for SWAP70

       genOway: Develop your customized and physiologically relevant rodent model for SWAP70

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    hsa-mir-124-3p (MIRT002694), hsa-mir-145-5p (MIRT006747)

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    Selected qRT-PCR Assays for microRNAs that regulate SWAP70 (see all 21):
    hsa-miR-15a hsa-let-7a-2* hsa-miR-340 hsa-miR-511 hsa-miR-144 hsa-miR-424 hsa-miR-550b hsa-let-7g*
    SwitchGear 3'UTR luciferase reporter plasmidSWAP70 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SWAP70

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SWP70_HUMAN, Q9UH65: Cytoplasm. Cell membrane. Nucleus. Cell projection, lamellipodium. Note=In resting B-cells
    it is localized mainly in the cytoplasm and upon cell activation it is recruited to the plasma membrane and then
    translocates to the nucleus. In activated, class-switching B-cells it is associated with membrane IgG but not
    IgM. Localized to loose actin filament arrays located behind actively extending lamellipodia
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    plasma membrane5
    cytosol3
    cytoskeleton2
    mitochondrion1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane IEA--
    GO:0030027lamellipodium IEA--

    Find genes that share ontologies with SWAP70           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SWAP70
    Interactions:

        Search GeneGlobe Interaction Network for SWAP70

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for SWAP70 (Q9UH653 ENSP000003156304) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NCLP193383, ENSP000003181954I2D: score=1 STRING: ENSP00000318195
    PARP1P098743, ENSP000003557594I2D: score=4 STRING: ENSP00000355759
    NPM1P067483, ENSP000002969304I2D: score=2 STRING: ENSP00000296930
    CELSR3Q9NYQ73, ENSP000001640244I2D: score=3 STRING: ENSP00000164024
    APPBP2Q926243I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016444somatic cell DNA recombination ----
    GO:0045190isotype switching IEA--

    Find genes that share ontologies with SWAP70           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SWAP70 (SWP70)

    3 HMDB Compounds for SWAP70    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    3 Novoseek inferred chemical compound relationships for SWAP70 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phosphoinositide 33.5 2 17454301 (1), 12925760 (1)
    tyrosine 9.5 2 17371938 (1), 11961559 (1)
    lipid 0 1 15163014 (1)



    Find genes that share compounds with SWAP70           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SWAP70 gene: 
    NM_015055.2  

    Unigene Cluster for SWAP70:

    SWAP switching B-cell complex 70kDa subunit
    Hs.153026  [show with all ESTs]
    Unigene Representative Sequence: NM_015055
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000447399 ENST00000318950(uc001mhw.3 uc001mhx.3) ENST00000526358
    ENST00000531814 ENST00000524817(uc001mhv.3) ENST00000534662 ENST00000534562

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate SWAP70 (see all 21):
    hsa-miR-15a hsa-let-7a-2* hsa-miR-340 hsa-miR-511 hsa-miR-144 hsa-miR-424 hsa-miR-550b hsa-let-7g*
    SwitchGear 3'UTR luciferase reporter plasmidSWAP70 3' UTR sequence
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      QuantiFast Probe-based Assays in human, mouse, rat SWAP70

    Additional mRNA sequence: 

    AB014540.1 AF134894.1 AF161439.1 AF210818.1 AK027131.1 AK096859.1 AK304104.1 AL110154.1 
    BC000134.2 BC000616.2 

    10 DOTS entries:

    DT.100818850  DT.452386  DT.99938965  DT.91765214  DT.95372557  DT.100818848  DT.100687484  DT.91765219 
    DT.95297954  DT.100039360 

    Selected AceView cDNA sequences (see all 261):

    BU171077 AF210818 AI139569 BM456737 AI743353 AI581705 AI568136 AI360845 
    AA374801 T91587 AA884032 BQ057608 AA761491 BQ642246 CA436896 AI360840 
    AI926340 AI191712 AI707975 AW291130 CA416936 BU735161 AA812089 CB159908 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SWAP70 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16
    SP1:                                -           -           -     -                                                                           
    SP2:                                                                                                              -     -     -     -         
    SP3:                                                        -     -                                                                           
    SP4:                                                                                                                                          
    SP5:                                -     -     -           -     -                                                                           


    ECgene alternative splicing isoforms for SWAP70

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SWAP70 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAGGAAACT
    SWAP70 Expression
    About this image


    SWAP70 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Blood (Hematopoietic System)
             Mature B-Cells Peripheral Blood
     
     Spleen (Hematopoietic System)
    SWAP70 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SWAP70 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.153026

    UniProtKB/Swiss-Prot: SWP70_HUMAN, Q9UH65
    Tissue specificity: Expressed only in mature B-cells including those associated with mucosa-associated tissue and
    bronchus-associated tissue (PubMed:10681448). Widely expressed. Abundant in spleen, and fairly abundant in
    kidney, lung and liver. Also found in monocytes and macrophages (PubMed:12925760)

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SWAP70 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Swap701 , 5 SWA-70 protein1, 5 89.52(n)1
    95.04(a)1
      7 (57.70 cM)5
    209471  NM_009302.31  NP_033328.31 
     1102217035 
    chicken
    (Gallus gallus)
    Aves SWAP701 SWAP switching B-cell complex 70kDa subunit 79.68(n)
    86.3(a)
      423044  NM_001031180.1  NP_001026351.1 
    lizard
    (Anolis carolinensis)
    Reptilia SWAP706
    SWAP switching B-cell complex 70kDa subunit
    84(a)
    1 ↔ 1
    1(64098628-64137624)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.137642 Xenopus laevis transcribed sequence with moderate similarity more 77.27(n)    BX846621.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc635992 hypothetical protein MGC63599 72.43(n)   393645  BC058058.1 
    mosquito
    (Anopheles gambiae)
    Insecta AgaP_AGAP0123321 AgaP_AGAP012332 45.6(n)
    34.3(a)
      4577474  XM_001238271.2  XP_001238272.2 


    ENSEMBL Gene Tree for SWAP70 (if available)
    TreeFam Gene Tree for SWAP70 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SWAP70 gene
    DEF62  
    3 SIMAP similar genes for SWAP70 using alignment to 6 protein entries:     SWP70_HUMAN (see all proteins):
    DEF6    FAM109A    PLEK2

    Find genes that share paralogs with SWAP70           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SWAP70 (see all 2233)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1132295991,2
    C--9683690(+) AAAAG-/AAAAAA 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1423535581,2
    --9683711(+) AATGCA/GTTTGG 1 -- us2k10--------
    rs1463051331,2
    C--9683720(+) GGATTA/GTATGA 1 -- us2k10--------
    rs1389588041,2
    --9683770(+) ATGTCC/GTGGTC 1 -- us2k10--------
    rs1915393781,2
    --9683893(+) TCTTTC/TTTCTT 1 -- us2k10--------
    rs1998777181,2
    --9683894(+) CTTTT-/TTCTTCTT 1 -- us2k10--------
    rs2008550311,2
    --9683904(+) CTTCT-/TCTTTTT 1 -- us2k10--------
    rs2005133491,2
    C--9683905(+) TTCTTC/TTTTTT 1 -- us2k10--------
    rs355997771,2
    C--9683906(+) TCTTC-/TTTTTT 1 -- us2k11Minor allele frequency- T:0.00NA 2
    rs1413449241,2
    --9683944(+) GACTTC/TGCATG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SWAP70 (9685624 - 9774538 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for SWAP70:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2744096CNV Deletion23290073
    esv2744095CNV Deletion23290073
    esv1146451CNV Deletion17803354
    esv2532017CNV Insertion19546169
    esv271180CNV Insertion20981092
    nsv527910CNV Loss19592680
    esv27859CNV Loss19812545
    nsv896987CNV Gain21882294
    nsv7215OTHER Inversion18451855
    nsv499766OTHER Inversion21111241

    Site Specific Mutation Identification with PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for SWAP70

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 604762    OMIM disorders: --

    2 diseases for SWAP70:    
    About MalaCards
    x-linked hyper igm syndrome    nodular lymphocyte predominant hodgkin lymphoma


    Find genes that share disorders with SWAP70           About GenesLikeMe

    4 Novoseek inferred disease relationships for SWAP70 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lymphoma b-cell 31.9 3 15163014 (3)
    hodgkin disease 27.5 2 15163014 (1)
    lymphoma 5.43 4 15163014 (1)
    immunodeficiency 0 1 11726218 (1)

    Genetic Association Database (GAD): SWAP70
    Human Genome Epidemiology (HuGE) Navigator: SWAP70 (1 document)

    Export disorders for SWAP70 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for SWAP70 gene, integrated from 10 sources (see all 41):
    (articles sorted by number of sources associating them with SWAP70)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Association of SWAP-70 with the B cell antigen receptor complex. (PubMed id 10681448)1, 2, 3, 9 Masat L.... Ferrick D. (Proc. Natl. Acad. Sci. U.S.A. 2000)
    2. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)1, 2, 3 Ishikawa K.... Ohara O. (DNA Res. 1998)
    3. SWAP-70 identifies a transitional subset of actin filaments in motile cells. (PubMed id 12925760)1, 2, 9 Hilpelae P.... Baehler M. (Mol. Biol. Cell 2003)
    4. Analysis of SWAP-70 as a candidate gene for non-X-linked hyper IgM syndrome and common variable immunodeficiency. (PubMed id 11726218)1, 2, 9 Rapalus L....Conley M.E. (Clin. Immunol. 2001)
    5. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Diagnostic surface expression of SWAP-70 on HIV-1 infected T cells. (PubMed id 16547421)1, 9 Kimbara N....Okada N. (Microbiol. Immunol. 2006)
    8. Expression and localization of SWAP-70 in human fetomaternal interface and placenta during tubal pregnancy and normal placentation. (PubMed id 17371938)1, 9 Liu J....Wang Y.L. (J. Histochem. Cytochem. 2007)
    9. Membrane-induced alteration of the secondary structure in the SWAP-70 pleckstrin homology domain. (PubMed id 22247562)1 Tokuda N....Tuzi S. (J. Biochem. 2012)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 23075 HGNC: 17070 AceView: SWAP70 Ensembl:ENSG00000133789 euGenes: HUgn23075
    ECgene: SWAP70 H-InvDB: SWAP70

    (According to HUGE)
    About This Section

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    HUGE: KIAA0640

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SWAP70 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SWAP70 gene:
    Search GeneIP for patents involving SWAP70

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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