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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SWAP70 Gene

protein-coding   GIFtS: 59
GCID: GC11P009642

SWAP Switching B-Cell Complex 70kDa Subunit

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
SWAP Switching B-Cell Complex 70kDa Subunit1 2
SWAP-702 3
Switch-Associated Protein 702
KIAA06403

External Ids:    HGNC: 170701   Entrez Gene: 230752   Ensembl: ENSG000001337897   OMIM: 6047625   UniProtKB: Q9UH653   

Export aliases for SWAP70 gene to outside databases

Previous GC identifers: GC11P010697 GC11P010255 GC11P009724 GC11P009649 GC11P009358


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SWAP70 Gene: 
SWAP70 (SWAP switching B-cell complex 70kDa subunit) is a protein-coding gene. Diseases associated with SWAP70 include nodular lymphocyte predominant hodgkin lymphoma, and x-linked hyper igm syndrome. GO annotations related to this gene include phospholipid binding and ATP binding. An important paralog of this gene is DEF6.

UniProtKB/Swiss-Prot: SWP70_HUMAN, Q9UH65
Function: Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which,
independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of
membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist
stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion (By similarity)

Gene Wiki entry for SWAP70 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_009237.18  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SWAP70 gene promoter:
         AREB6   RP58   POU2F1   POU2F1b   POU2F1a   ARP-1   POU2F1c   XBP-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSWAP70 promoter sequence
   Search SABiosciences Chromatin IP Primers for SWAP70

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SWAP70


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15

SWAP70 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SWAP70 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P009642:  view genomic region     (about GC identifiers)

Start:
9,685,624 bp from pter      End:
9,774,538 bp from pter
Size:
88,915 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SWP70_HUMAN, Q9UH65 (See protein sequence)
Recommended Name: Switch-associated protein 70  
Size: 585 amino acids; 68998 Da
Subunit: The SWAP complex consists of NPM1, NCL, PARP1 and SWAP70 (By similarity)
Subcellular location: Cytoplasm. Cell membrane. Nucleus. Cell projection, lamellipodium. Note=In resting B-cells
it is localized mainly in the cytoplasm and upon cell activation it is recruited to the plasma membrane and then
translocates to the nucleus. In activated, class-switching B-cells it is associated with membrane IgG but not
IgM. Localized to loose actin filament arrays located behind actively extending lamellipodia
Sequence caution: Sequence=AAF28999.1; Type=Frameshift; Positions=480, 483; Sequence=BAA31615.1; Type=Erroneous
initiation;
1 PDB 3D structure from and Proteopedia for SWAP70:
2DN6 (3D)    
Secondary accessions: D3DQV1 O75135 Q7LCY6 Q9P061 Q9P0Z8

Explore the universe of human proteins at neXtProt for SWAP70: NX_Q9UH65

Explore proteomics data for SWAP70 at MOPED 

Post-translational modifications:

  • UniProtKB: Tyrosine-phosphorylated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UH65

  • SWAP70 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SWAP70 Protein Expression
    REFSEQ proteins: NP_055870.2  
    ENSEMBL proteins: 
     ENSP00000399056   ENSP00000315630   ENSP00000431768   ENSP00000435587   ENSP00000433824  

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    Cloud-Clone Corp. Proteins for SWAP70 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA--
    GO:0005886plasma membrane IDA--
    GO:0030027lamellipodium IEA--

    SWAP70 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PLEKH: Pleckstrin homology (PH) domain containing
    EFHAND: EF-hand domain containing

    3 InterPro protein domains:
     IPR002048 EF_hand_dom
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom

    Graphical View of Domain Structure for InterPro Entry Q9UH65

    ProtoNet protein and cluster: Q9UH65

    1 Blocks protein domain: IPB001849 Pleckstrin-like

    UniProtKB/Swiss-Prot: SWP70_HUMAN, Q9UH65
    Domain: The PH domain is essential for phosphatidylinositol 3,4,5-trisphosphate binding
    Similarity: Contains 1 PH domain


    SWAP70 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SWP70_HUMAN, Q9UH65
    Function: Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which,
    independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of
    membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist
    stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion (By similarity)

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding ----
    GO:0005524ATP binding IEA--
    GO:0005543phospholipid binding IEA--
         
    SWAP70 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Swap70):
     cellular  hematopoietic system  immune system 

    SWAP70 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Swap70tm1Jess for SWAP70

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    hsa-miR-15a hsa-let-7a-2* hsa-miR-340 hsa-miR-511 hsa-miR-144 hsa-miR-424 hsa-miR-550b hsa-let-7g*
    SwitchGear 3'UTR luciferase reporter plasmidSWAP70 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SWAP70

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/8 Interacting proteins for SWAP70 (Q9UH653 ENSP000003156304) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NCLP193383, ENSP000003181954I2D: score=1 STRING: ENSP00000318195
    PARP1P098743, ENSP000003557594I2D: score=4 STRING: ENSP00000355759
    NPM1P067483, ENSP000002969304I2D: score=2 STRING: ENSP00000296930
    CELSR3Q9NYQ73, ENSP000001640244I2D: score=3 STRING: ENSP00000164024
    APPBP2Q926243I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016444somatic cell DNA recombination ----
    GO:0045190isotype switching IEA--

    SWAP70 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SWAP70 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SWAP70 (SWP70)

    3 HMDB Compounds for SWAP70    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    3 Novoseek inferred chemical compound relationships for SWAP70 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phosphoinositide 33.5 2 17454301 (1), 12925760 (1)
    tyrosine 9.5 2 17371938 (1), 11961559 (1)
    lipid 0 1 15163014 (1)

    Search CenterWatch for drugs/clinical trials and news about SWAP70 / SWP70

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for SWAP70 gene: 
    NM_015055.2  

    Unigene Cluster for SWAP70:

    SWAP switching B-cell complex 70kDa subunit
    Hs.153026  [show with all ESTs]
    Unigene Representative Sequence: NM_015055
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000447399 ENST00000318950(uc001mhw.3 uc001mhx.3) ENST00000526358
    ENST00000531814 ENST00000524817(uc001mhv.3) ENST00000534662 ENST00000534562

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    hsa-miR-15a hsa-let-7a-2* hsa-miR-340 hsa-miR-511 hsa-miR-144 hsa-miR-424 hsa-miR-550b hsa-let-7g*
    SwitchGear 3'UTR luciferase reporter plasmidSWAP70 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AB014540.1 AF134894.1 AF161439.1 AF210818.1 AK027131.1 AK096859.1 AK304104.1 AL110154.1 
    BC000134.2 BC000616.2 

    10 DOTS entries:

    DT.100818850  DT.452386  DT.99938965  DT.91765214  DT.95372557  DT.100818848  DT.100687484  DT.91765219 
    DT.95297954  DT.100039360 

    24/261 AceView cDNA sequences (see all 261):

    BQ720437 BQ642246 BQ063894 N28620 AI360840 CA416936 BU171077 AI926340 
    AA374801 AA884032 AI568136 AA767294 AW291130 CA436896 BQ057608 BU683483 
    BQ213729 BU151276 AA737061 AA768170 CB159908 BU741951 AA442783 AA612923 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for SWAP70 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16
    SP1:                                -           -           -     -                                                                           
    SP2:                                                                                                              -     -     -     -         
    SP3:                                                        -     -                                                                           
    SP4:                                                                                                                                          
    SP5:                                -     -     -           -     -                                                                           


    ECgene alternative splicing isoforms for SWAP70

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SWAP70 expression in normal human tissues (normalized intensities)      SWAP70 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAGGAAACT
    SWAP70 Expression
    About this image


    SWAP70 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/12 selected tissues (see all 12) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             bronchus ; respiratory epithelial cells   
     
     Stomach (Gastrointestinal Tract)    fully expand to see all 2 entries
             stomach, upper ; glandular cells   
     
     Colon (Gastrointestinal Tract)
             colon ; endothelial cells   
     
     Uterus (Reproductive System)
             uterus, post-menopause ; glandular cells   

    See SWAP70 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SWAP70

    SOURCE GeneReport for Unigene cluster: Hs.153026

    UniProtKB/Swiss-Prot: SWP70_HUMAN, Q9UH65
    Tissue specificity: Expressed only in mature B-cells including those associated with mucosa-associated tissue and
    bronchus-associated tissue (PubMed:10681448). Widely expressed. Abundant in spleen, and fairly abundant in
    kidney, lung and liver. Also found in monocytes and macrophages (PubMed:12925760)

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SWAP70

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for SWAP70 gene from 5/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Swap701 , 5 SWA-70 protein1, 5 89.52(n)1
    95.04(a)1
      7 (57.70 cM)5
    209471  NM_009302.31  NP_033328.31 
     1102217035 
    chicken
    (Gallus gallus)
    Aves SWAP701 SWAP switching B-cell complex 70kDa subunit 79.68(n)
    86.3(a)
      423044  NM_001031180.1  NP_001026351.1 
    lizard
    (Anolis carolinensis)
    Reptilia SWAP706
    Uncharacterized protein
    84(a)
    1 ↔ 1
    1(64098628-64137624)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.137642 Xenopus laevis transcribed sequence with moderate similarity more 77.27(n)    BX846621.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc635992 hypothetical protein MGC63599 72.43(n)   393645  BC058058.1 


    ENSEMBL Gene Tree for SWAP70 (if available)
    TreeFam Gene Tree for SWAP70 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SWAP70 gene
    DEF62  
    3 SIMAP similar genes for SWAP70 using alignment to 6 protein entries:     SWP70_HUMAN (see all proteins):
    DEF6    FAM109A    PLEK2

    SWAP70 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2233 SNPs in SWAP70 are shown (see all 2233)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1132295991,2
    C--9683690(+) AAAAG-/AAAAAA 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1423535581,2
    --9683711(+) AATGCA/GTTTGG 1 -- us2k10--------
    rs1463051331,2
    C--9683720(+) GGATTA/GTATGA 1 -- us2k10--------
    rs1389588041,2
    --9683770(+) ATGTCC/GTGGTC 1 -- us2k10--------
    rs1915393781,2
    --9683893(+) TCTTTC/TTTCTT 1 -- us2k10--------
    rs1998777181,2
    --9683894(+) CTTTT-/TTCTTCTT 1 -- us2k10--------
    rs2008550311,2
    --9683904(+) CTTCT-/TCTTTTT 1 -- us2k10--------
    rs2005133491,2
    C--9683905(+) TTCTTC/TTTTTT 1 -- us2k10--------
    rs355997771,2
    C--9683906(+) TCTTC-/TTTTTT 1 -- us2k11Minor allele frequency- T:0.00NA 2
    rs1413449241,2
    --9683944(+) GACTTC/TGCATG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SWAP70 (9685624 - 9774538 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for SWAP70:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2744096CNV Deletion23290073
    esv2744095CNV Deletion23290073
    esv1146451CNV Deletion17803354
    esv2532017CNV Insertion19546169
    esv271180CNV Insertion20981092
    nsv527910CNV Loss19592680
    esv27859CNV Loss19812545
    nsv896987CNV Gain21882294
    nsv7215OTHER Inversion18451855
    nsv499766OTHER Inversion21111241

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604762    OMIM disorders: --

    7 diseases for SWAP70:    About MalaCards
    nodular lymphocyte predominant hodgkin lymphoma    x-linked hyper igm syndrome    common variable immunodeficiency    malignant glioma
    b-cell lymphomas    hodgkin's lymphoma    breast cancer


    SWAP70 for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for SWAP70 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lymphoma b-cell 31.9 3 15163014 (3)
    hodgkin disease 27.5 2 15163014 (1)
    lymphoma 5.43 4 15163014 (1)
    immunodeficiency 0 1 11726218 (1)

    Genetic Association Database (GAD): SWAP70
    Human Genome Epidemiology (HuGE) Navigator: SWAP70 (1 document)

    Export disorders for SWAP70 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SWAP70 gene, integrated from 9 sources (see all 41):
    (articles sorted by number of sources associating them with SWAP70)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Association of SWAP-70 with the B cell antigen receptor complex. (PubMed id 10681448)1, 2, 3, 9 Masat L.... Ferrick D. (2000)
    2. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)1, 2, 3 Ishikawa K.... Ohara O. (1998)
    3. SWAP-70 identifies a transitional subset of actin filaments in motile cells. (PubMed id 12925760)1, 2, 9 Hilpelae P.... Baehler M. (2003)
    4. Analysis of SWAP-70 as a candidate gene for non-X-linked hyper IgM syndrome and common variable immunodeficiency. (PubMed id 11726218)1, 2, 9 Rapalus L....Conley M.E. (2001)
    5. Investigation of genetic susceptibility factors for h uman longevity - A targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (2010)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Diagnostic surface expression of SWAP-70 on HIV-1 infected T cells. (PubMed id 16547421)1, 9 Kimbara N....Okada N. (2006)
    8. Expression and localization of SWAP-70 in human fetomaternal interface and placenta during tubal pregnancy and normal placentation. (PubMed id 17371938)1, 9 Liu J....Wang Y.L. (2007)
    9. Membrane-induced alteration of the secondary structure in the SWAP-70 pleckstrin homology domain. (PubMed id 22247562)1 Tokuda N....Tuzi S. (2012)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23075 HGNC: 17070 AceView: SWAP70 Ensembl:ENSG00000133789 euGenes: HUgn23075
    ECgene: SWAP70 H-InvDB: SWAP70

    (According to HUGE)
    About This Section
    HUGE: KIAA0640

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SWAP70 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SWAP70 gene:
    Search GeneIP for patents involving SWAP70

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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