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Aliases for SVOPL Gene

Aliases for SVOPL Gene

  • SVOP Like 2 3
  • SVOP-Like 2 3 5
  • SVOP-Like Protein 3 4
  • SV2 Related Protein Homolog (Rat)-Like 2
  • SV2 Related Protein Homolog-Like 3
  • SV2-Related Protein-Like 4

External Ids for SVOPL Gene

Previous GeneCards Identifiers for SVOPL Gene

  • GC07M137930
  • GC07M138279
  • GC07M132588

Summaries for SVOPL Gene

GeneCards Summary for SVOPL Gene

SVOPL (SVOP Like) is a Protein Coding gene. GO annotations related to this gene include transmembrane transporter activity. An important paralog of this gene is SV2C.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SVOPL Gene

Genomics for SVOPL Gene

Regulatory Elements for SVOPL Gene

Enhancers for SVOPL Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SVOPL on UCSC Golden Path with GeneCards custom track

Genomic Location for SVOPL Gene

138,594,285 bp from pter
138,701,354 bp from pter
107,070 bases
Minus strand

Genomic View for SVOPL Gene

Genes around SVOPL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SVOPL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SVOPL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SVOPL Gene

Proteins for SVOPL Gene

  • Protein details for SVOPL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative transporter SVOPL
    Protein Accession:

    Protein attributes for SVOPL Gene

    492 amino acids
    Molecular mass:
    53991 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SVOPL Gene


neXtProt entry for SVOPL Gene

Proteomics data for SVOPL Gene at MOPED

Post-translational modifications for SVOPL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SVOPL Gene

No data available for DME Specific Peptides for SVOPL Gene

Domains & Families for SVOPL Gene

Protein Domains for SVOPL Gene

Suggested Antigen Peptide Sequences for SVOPL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the major facilitator superfamily.
  • Belongs to the major facilitator superfamily.
genes like me logo Genes that share domains with SVOPL: view

No data available for Gene Families for SVOPL Gene

Function for SVOPL Gene

genes like me logo Genes that share phenotypes with SVOPL: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SVOPL

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SVOPL Gene

Localization for SVOPL Gene

Subcellular locations from UniProtKB/Swiss-Prot for SVOPL Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SVOPL Gene COMPARTMENTS Subcellular localization image for SVOPL gene
Compartment Confidence
plasma membrane 3

No data available for Gene Ontology (GO) - Cellular Components for SVOPL Gene

Pathways & Interactions for SVOPL Gene

SuperPathways for SVOPL Gene

No Data Available

Interacting Proteins for SVOPL Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000405482 for SVOPL Gene via STRING

Gene Ontology (GO) - Biological Process for SVOPL Gene


No data available for Pathways by source and SIGNOR curated interactions for SVOPL Gene

Drugs & Compounds for SVOPL Gene

No Compound Related Data Available

Transcripts for SVOPL Gene

mRNA/cDNA for SVOPL Gene

Unigene Clusters for SVOPL Gene

Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SVOPL Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12
SP1: - -

Relevant External Links for SVOPL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SVOPL Gene

mRNA expression in normal human tissues for SVOPL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SVOPL Gene

This gene is overexpressed in Testis (x8.2) and Kidney - Cortex (x7.8).

SOURCE GeneReport for Unigene cluster for SVOPL Gene Hs.99414

genes like me logo Genes that share expression patterns with SVOPL: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SVOPL Gene

Orthologs for SVOPL Gene

This gene was present in the common ancestor of chordates.

Orthologs for SVOPL Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SVOPL 35
  • 88.89 (n)
  • 92.89 (a)
  • 93 (a)
(Canis familiaris)
Mammalia SVOPL 35
  • 88.07 (n)
  • 92.39 (a)
  • 78 (a)
(Mus musculus)
Mammalia Svopl 35
  • 87.53 (n)
  • 92.07 (a)
Svopl 16
Svopl 36
  • 91 (a)
(Pan troglodytes)
Mammalia SVOPL 35
  • 99.32 (n)
  • 98.98 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia RGD1566053 35
  • 84.66 (n)
  • 89.16 (a)
(Monodelphis domestica)
Mammalia SVOPL 36
  • 90 (a)
(Ornithorhynchus anatinus)
Mammalia SVOPL 36
  • 66 (a)
(Gallus gallus)
Aves SVOPL 35
  • 76.94 (n)
  • 83.88 (a)
  • 84 (a)
(Anolis carolinensis)
Reptilia SVOPL 36
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia svopl 35
  • 69.74 (n)
  • 74.9 (a)
(Danio rerio)
Actinopterygii svopl 35
  • 60 (n)
  • 56.77 (a)
svopl 36
  • 52 (a)
Species with no ortholog for SVOPL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SVOPL Gene

Gene Tree for SVOPL (if available)
Gene Tree for SVOPL (if available)

Paralogs for SVOPL Gene

Paralogs for SVOPL Gene

(2) SIMAP similar genes for SVOPL Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SVOPL: view

Variants for SVOPL Gene

Sequence variations from dbSNP and Humsavar for SVOPL Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs2305816 - 138,627,377(+) GAAGG(A/C/T)AGAAT reference, missense
rs897822 -- 138,668,400(-) CTTGC(A/C)CGCTG intron-variant
rs897823 -- 138,668,398(-) TGCCC(A/G)CTGAC intron-variant
rs897824 -- 138,668,144(-) TTCCT(A/G)AGTGG intron-variant
rs963279 -- 138,603,087(+) ACTGG(A/G)ACACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SVOPL Gene

Variant ID Type Subtype PubMed ID
esv2735212 CNV Deletion 23290073
nsv5968 CNV Insertion 18451855
esv993410 CNV Deletion 20482838
esv2735218 CNV Deletion 23290073
esv3359 CNV Deletion 18987735
esv7121 CNV Loss 19470904
esv1010083 CNV Deletion 20482838
nsv512927 CNV Insertion 21212237
esv2735219 CNV Deletion 23290073
esv2657210 CNV Deletion 23128226
esv1471021 CNV Deletion 17803354
esv6486 CNV Loss 19470904
esv2543778 CNV Deletion 19546169
esv2735220 CNV Deletion 23290073
esv2735221 CNV Deletion 23290073
esv2735222 CNV Deletion 23290073
nsv365934 CNV Loss 16902084
nsv512928 CNV Insertion 21212237
esv2678647 CNV Deletion 23128226
esv2659373 CNV Deletion 23128226

Variation tolerance for SVOPL Gene

Residual Variation Intolerance Score: 97.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.47; 96.43% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SVOPL Gene

Disorders for SVOPL Gene

Relevant External Links for SVOPL

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SVOPL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SVOPL Gene

Publications for SVOPL Gene

  1. Identification of six putative human transporters with structural similarity to the drug transporter SLC22 family. (PMID: 17714910) Jacobsson J.A. … Fredriksson R. (Genomics 2007) 3 4 67
  2. Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. (PMID: 21565611) Sang L. … Jackson P.K. (Cell 2011) 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for SVOPL Gene

Sources for SVOPL Gene