Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SVOPL Gene

Aliases for SVOPL Gene

  • SVOP Like 2 3 5
  • SV2 Related Protein Homolog (Rat)-Like 2
  • SV2-Related Protein-Like 4
  • SVOP-Like Protein 4
  • SVOP-Like 2

External Ids for SVOPL Gene

Previous GeneCards Identifiers for SVOPL Gene

  • GC07M137930
  • GC07M138279
  • GC07M132588

Summaries for SVOPL Gene

Entrez Gene Summary for SVOPL Gene

  • The protein encoded by this gene is thought to be a member of solute carrier family 22, which includes transmembrane proteins that transport toxins and drugs from the body. This gene is a paralog of the SVOP gene that encodes synaptic vesicle 2-related protein. [provided by RefSeq, Sep 2016]

GeneCards Summary for SVOPL Gene

SVOPL (SVOP Like) is a Protein Coding gene. GO annotations related to this gene include transmembrane transporter activity. An important paralog of this gene is SVOP.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SVOPL Gene

Genomics for SVOPL Gene

Regulatory Elements for SVOPL Gene

Enhancers for SVOPL Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F138667 1.1 ENCODE 13.2 +32.7 32738 1.4 PKNOX1 MLX ARNT CREB3L1 ARID4B DMAP1 ZNF766 CBX5 KLF13 SP5 SVOPL UQCRFS1P2 ENSG00000252188 RPL17P27 RPL21P73
GH07F138738 1.1 Ensembl ENCODE 10.8 -37.5 -37537 1.2 ZNF133 ARID4B ZNF2 RAD21 RFX5 YY1 ZNF143 RCOR1 ZNF391 DEK UQCRFS1P2 SVOPL ENSG00000201465 TMEM213
GH07F138669 0.8 ENCODE 13.2 +31.8 31824 0.2 BCOR YBX3 PKNOX1 NFRKB BACH1 PTRF PYGO2 ZNF384 CHAMP1 RELA SVOPL UQCRFS1P2 ENSG00000252188 RPL17P27 RPL21P73
GH07F138602 0.6 ENCODE 12.5 +97.7 97689 2.1 CTCF CBX3 CEBPA HNF4G CEBPB CEBPG ENSG00000252188 SVOPL TRIM24 GC07M138626 RPS3AP28
GH07F138613 0.7 ENCODE 10.4 +87.0 86952 1.0 SOX13 NFIA HLF FOXA3 ZNF384 CEBPG RARA ZNF316 KDM1A BCL6 SVOPL UQCRFS1P2 ENSG00000252188 GC07M138626 RPS3AP28
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SVOPL on UCSC Golden Path with GeneCards custom track

Genomic Location for SVOPL Gene

138,594,285 bp from pter
138,701,354 bp from pter
107,070 bases
Minus strand

Genomic View for SVOPL Gene

Genes around SVOPL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SVOPL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SVOPL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SVOPL Gene

Proteins for SVOPL Gene

  • Protein details for SVOPL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative transporter SVOPL
    Protein Accession:

    Protein attributes for SVOPL Gene

    492 amino acids
    Molecular mass:
    53991 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SVOPL Gene


neXtProt entry for SVOPL Gene

Post-translational modifications for SVOPL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SVOPL Gene

Domains & Families for SVOPL Gene

Protein Domains for SVOPL Gene

Suggested Antigen Peptide Sequences for SVOPL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the major facilitator superfamily.
  • Belongs to the major facilitator superfamily.
genes like me logo Genes that share domains with SVOPL: view

No data available for Gene Families for SVOPL Gene

Function for SVOPL Gene

Gene Ontology (GO) - Molecular Function for SVOPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0022857 transmembrane transporter activity IEA --
GO:0022891 substrate-specific transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with SVOPL: view
genes like me logo Genes that share phenotypes with SVOPL: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SVOPL

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SVOPL Gene

Localization for SVOPL Gene

Subcellular locations from UniProtKB/Swiss-Prot for SVOPL Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SVOPL gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for SVOPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with SVOPL: view

Pathways & Interactions for SVOPL Gene

SuperPathways for SVOPL Gene

No Data Available

Interacting Proteins for SVOPL Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000405482 Q8N434-SVOPL_HUMAN for SVOPL Gene via STRING IID

Gene Ontology (GO) - Biological Process for SVOPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SVOPL: view

No data available for Pathways by source and SIGNOR curated interactions for SVOPL Gene

Transcripts for SVOPL Gene

mRNA/cDNA for SVOPL Gene

Unigene Clusters for SVOPL Gene

Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SVOPL Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12
SP1: - -

Relevant External Links for SVOPL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SVOPL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SVOPL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SVOPL Gene

This gene is overexpressed in Testis (x8.2) and Kidney - Cortex (x7.8).

NURSA nuclear receptor signaling pathways regulating expression of SVOPL Gene:


SOURCE GeneReport for Unigene cluster for SVOPL Gene:

genes like me logo Genes that share expression patterns with SVOPL: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for SVOPL Gene

Orthologs for SVOPL Gene

This gene was present in the common ancestor of chordates.

Orthologs for SVOPL Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SVOPL 34 35
  • 99.32 (n)
(Monodelphis domestica)
Mammalia SVOPL 35
  • 90 (a)
(Bos Taurus)
Mammalia SVOPL 34 35
  • 88.89 (n)
(Canis familiaris)
Mammalia SVOPL 34 35
  • 88.07 (n)
(Mus musculus)
Mammalia Svopl 34 16 35
  • 87.53 (n)
(Rattus norvegicus)
Mammalia RGD1566053 34
  • 84.66 (n)
(Ornithorhynchus anatinus)
Mammalia SVOPL 35
  • 66 (a)
(Gallus gallus)
Aves SVOPL 34 35
  • 76.94 (n)
(Anolis carolinensis)
Reptilia SVOPL 35
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia svopl 34
  • 69.74 (n)
(Danio rerio)
Actinopterygii svopl 34 35
  • 60 (n)
Species where no ortholog for SVOPL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SVOPL Gene

Gene Tree for SVOPL (if available)
Gene Tree for SVOPL (if available)

Paralogs for SVOPL Gene

Paralogs for SVOPL Gene

(2) SIMAP similar genes for SVOPL Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SVOPL: view

Variants for SVOPL Gene

Sequence variations from dbSNP and Humsavar for SVOPL Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1015343 -- 138,668,442(-) gaggg(C/T)gtgac intron-variant
rs10224172 -- 138,634,213(+) TCAAA(A/G)TCTGC intron-variant
rs10225514 -- 138,701,002(+) GTAGA(C/T)CTTTT intron-variant
rs10225768 -- 138,701,191(+) ATTCC(G/T)TGGAC utr-variant-5-prime
rs10225769 -- 138,701,199(+) GACAG(C/T)CTTCC utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for SVOPL Gene

Variant ID Type Subtype PubMed ID
esv2543778 CNV deletion 19546169
esv1471021 CNV deletion 17803354
esv1010083 CNV deletion 20482838
nsv970584 CNV duplication 23825009
nsv956979 CNV deletion 24416366
nsv5968 CNV insertion 18451855
nsv512928 CNV insertion 21212237
nsv512927 CNV insertion 21212237
nsv365934 CNV deletion 16902084
nsv1140852 CNV deletion 24896259
nsv1120922 CNV deletion 24896259
nsv1119138 CNV deletion 24896259
nsv1112160 CNV deletion 24896259
nsv1109920 CNV deletion 24896259
nsv1076954 CNV deletion 25765185
nsv1076002 CNV deletion 25765185
nsv1030956 CNV gain 25217958
esv993410 CNV deletion 20482838
esv7121 CNV loss 19470904
esv6486 CNV loss 19470904
esv3615197 CNV loss 21293372
esv3615196 CNV loss 21293372
esv3542507 CNV deletion 23714750
esv3542506 CNV deletion 23714750
esv3542505 CNV deletion 23714750
esv3542504 CNV deletion 23714750
esv3438653 CNV duplication 20981092
esv3359 CNV loss 18987735
esv2735222 CNV deletion 23290073
esv2735221 CNV deletion 23290073
esv2735220 CNV deletion 23290073
esv2735219 CNV deletion 23290073
esv2735218 CNV deletion 23290073
esv2735212 CNV deletion 23290073
esv2678647 CNV deletion 23128226
esv2659373 CNV deletion 23128226
esv2657210 CNV deletion 23128226

Variation tolerance for SVOPL Gene

Residual Variation Intolerance Score: 97.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.47; 96.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SVOPL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SVOPL Gene

Disorders for SVOPL Gene

Relevant External Links for SVOPL

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SVOPL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SVOPL Gene

Publications for SVOPL Gene

  1. Identification of six putative human transporters with structural similarity to the drug transporter SLC22 family. (PMID: 17714910) Jacobsson J.A. … Fredriksson R. (Genomics 2007) 3 4 64
  2. Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. (PMID: 21565611) Sang L. … Jackson P.K. (Cell 2011) 3 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  4. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 4 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for SVOPL Gene

Sources for SVOPL Gene

Loading form....