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SVOPL Gene

protein-coding   GIFtS: 42
GCID: GC07M138279

SVOP-Like

(Previous name: SV2 related protein homolog (rat)-like)
  Search for SVOPL
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SVOP-like1 2
SVOP-Like Protein2 3
SV2 Related Protein Homolog (Rat)-Like1
Putative Transporter SVOPL2
SV2 Related Protein Homolog-Like2
SV2-Related Protein-Like3

External Ids:    HGNC: 270341   Entrez Gene: 1363062   Ensembl: ENSG000001577037   OMIM: 6117005   UniProtKB: Q8N4343   

Export aliases for SVOPL gene to outside databases

Previous GC identifers: GC07M137930 GC07M132588


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SVOPL Gene:
SVOPL (SVOP-like) is a protein-coding gene. GO annotations related to this gene include transmembrane transporter activity. An important paralog of this gene is SV2B.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SVOPL gene promoter:
         AP-2beta   ITF-2   Tal-1beta   AP-2alpha   AP-2gamma   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSVOPL promoter sequence
   Search Chromatin IP Primers for SVOPL

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SVOPL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q34   Ensembl cytogenetic band:  7q34   HGNC cytogenetic band: 7q34

SVOPL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SVOPL gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M138279:  view genomic region     (about GC identifiers)

Start:
138,279,030 bp from pter      End:
138,386,097 bp from pter
Size:
107,068 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 137,624,061-137,707,981     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SVOPL_HUMAN, Q8N434 (See protein sequence)
Recommended Name: Putative transporter SVOPL  
Size: 492 amino acids; 53991 Da
Alternative splicing: 2 isoforms:  Q8N434-1   Q8N434-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SVOPL: NX_Q8N434

Explore proteomics data for SVOPL at MOPED


See SVOPL Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts): 
NP_001132928.1  NP_777619.1  

ENSEMBL proteins: 
 ENSP00000288513   ENSP00000393487   ENSP00000412830   ENSP00000405482   ENSP00000417018  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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4 InterPro protein domains:
 IPR005828 Sub_transporter
 IPR020846 MFS_dom
 IPR011701 MFS
 IPR016196 MFS_dom_general_subst_transpt

Graphical View of Domain Structure for InterPro Entry Q8N434

ProtoNet protein and cluster: Q8N434

UniProtKB/Swiss-Prot: SVOPL_HUMAN, Q8N434
Similarity: Belongs to the major facilitator superfamily


SVOPL for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0022857transmembrane transporter activity IEA--
     
SVOPL for ontologies           About GeneDecksing


Animal Models:
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Inhib. RNA
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
SVOPL_HUMAN, Q8N434: Membrane; Multi-pass membrane protein (Potential)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
plasma membrane3
nucleus1

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016021integral component of membrane IEA--

SVOPL for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SVOPL
Interactions:

    Search GeneGlobe Interaction Network for SVOPL

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for SVOPL (ENSP000004054824) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
IQCB1ENSP000003115054STRING: ENSP00000311505
About this table

Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0055085transmembrane transport ----

SVOPL for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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  Browse compounds at ApexBio 

Browse Tocris compounds for SVOPL



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for SVOPL gene (2 alternative transcripts): 
NM_001139456.1  NM_174959.3  

Unigene Cluster for SVOPL:

SVOP-like
Hs.99414  [show with all ESTs]
Unigene Representative Sequence: BX648789
7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000288513 ENST00000441685(uc011kqh.2) ENST00000421622 ENST00000478865
ENST00000463557 ENST00000419765 ENST00000436657(uc003vue.3)
miRNA
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1 qRT-PCR Assays for microRNA that regulate SVOPL:
hsa-miR-664
SwitchGear 3'UTR luciferase reporter plasmidSVOPL 3' UTR sequence
Inhib. RNA
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SVOPL
Primer
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  QuantiFast Probe-based Assays in human, mouse, rat SVOPL

Additional mRNA sequence: 

BC036796.1 BX648789.1 

3 DOTS entries:

DT.91895063  DT.97774923  DT.100735258 

12 AceView cDNA sequences:

AL704123 BF939622 BX349158 BX648789 NM_174959 BM906451 BX106936 BX401218 
AA455898 AA455897 BC036796 AV743859 

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for SVOPL    About this scheme

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12
SP1:        -                                                     -               
SP2:                                                                              


ECgene alternative splicing isoforms for SVOPL

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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SVOPL expression in normal human tissues (normalized intensities)      SVOPL embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CTGTCAGGAC
SVOPL Expression
About this image


SVOPL expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 5) fully expand
 
 Bone (Muscoskeletal System)    fully expand to see all 2 entries
         Zeugopod Growth Plate
 
 Kidney (Urinary System)    fully expand to see all 2 entries
         Metanephros
 
 Ovary (Reproductive System)
         Secondary Oocyte Antral Follicle
 
 Adipose (Muscoskeletal System)
         Interscapular Brown Adipose Depot
 
 Gonad
         Secondary Oocyte Antral Follicle
SVOPL Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

SVOPL Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.99414
    Custom PCR Arrays for SVOPL
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SVOPL

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for SVOPL gene from Selected species (see all 11)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Svopl1 , 5 SV2 related protein homolog (rat)-like1, 5 87.53(n)1
92.07(a)1
  6 (17.34 cM)5
3205901  NM_177200.41  NP_796174.21 
 379837395 
chicken
(Gallus gallus)
Aves SVOPL1 SVOP-like 76.94(n)
83.88(a)
  418105  XM_416339.4  XP_416339.4 
lizard
(Anolis carolinensis)
Reptilia SVOPL6
SVOP-like
78(a)
1 ↔ 1
5(14919325-14948374)
tropical clawed frog
(Xenopus tropicalis)
Amphibia svopl1 SVOP-like 69.74(n)
74.9(a)
  100491296  XM_002940328.2  XP_002940374.2 
zebrafish
(Danio rerio)
Actinopterygii svopl1 SVOP-like 60(n)
56.77(a)
  492766  NM_001007407.2  NP_001007408.2 


ENSEMBL Gene Tree for SVOPL (if available)
TreeFam Gene Tree for SVOPL (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for SVOPL gene
SV2B2  SV2C2  SV2A2  SVOP2  
2 SIMAP similar genes for SVOPL using alignment to 3 protein entries:     SVOPL_HUMAN (see all proteins):
SLC22A7    SVOP

SVOPL for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for SVOPL (see all 2495)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 7 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs594002171,2
C--137632236(+) TATAT-/ATATATAT
ATATATATAT
GTAGA
2 -- int11Minor allele frequency- ATATATATATATATATAT:0.00NA 2
rs715200111,2
C--137676789(+) GTTTC-/A/AA  
        
AAAAA
2 -- int11NA 2
rs1438340291,2
--138278590(+) ATCACC/TATAAC 2 -- ds50010--------
rs747992761,2
C,F--138278702(+) ATGGCG/AGAAAG 2 -- ds50014Minor allele frequency- A:0.07NA CSA WA 242
rs1813726721,2
C--138278750(+) GATTCC/TCCCTA 2 -- ds50010--------
rs1442820841,2
C--138278834(+) GTAAT-/ACTC  
        
ACTCT
2 -- ds50010--------
rs16163181,2
C,F,A,H--138278913(-) CAAATT/CCAAAT 2 -- ds500127Minor allele frequency- C:0.29NA NS EA WA CSA 2491
rs1481630171,2
C--138278963(+) CCCAGG/TTTCTT 2 -- ds50010--------
rs1856957481,2
--138278997(+) CAAGTG/TTAGCT 2 -- ds50010--------
rs1909455481,2
--138279033(+) TGTAAG/TTTTAA 2 -- ut310--------

HapMap Linkage Disequilibrium report for SVOPL (138279030 - 138386097 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for SVOPL (see all 20):    About this table    
Variant IDTypeSubtypePubMed ID
esv2735218CNV Deletion23290073
esv2678647CNV Deletion23128226
esv2735219CNV Deletion23290073
esv1010083CNV Deletion20482838
esv2657210CNV Deletion23128226
esv2543778CNV Deletion19546169
esv2735212CNV Deletion23290073
esv3359CNV Deletion18987735
esv2659373CNV Deletion23128226
esv1471021CNV Deletion17803354

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 611700    OMIM disorders: --


SVOPL for disorders           About GeneDecksing


Export disorders for SVOPL gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for SVOPL gene integrated from 10 sources:
(articles sorted by number of sources associating them with SVOPL)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Identification of six putative human transporters with structural similarity to the drug transporter SLC22 family. (PubMed id 17714910)1, 2 Jacobsson J.A.... Fredriksson R. (Genomics 2007)
  2. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
  3. Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. (PubMed id 21565611)1 Sang L.... Jackson P.K. (Cell 2011)
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  5. The DNA sequence of human chromosome 7. (PubMed id 12853948)2 Hillier L.W.... Wilson R.K. (Nature 2003)
  6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 136306 HGNC: 27034 AceView: LOC136306 Ensembl:ENSG00000157703 euGenes: HUgn136306
ECgene: SVOPL H-InvDB: SVOPL

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for SVOPL Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for SVOPL gene:
Search GeneIP for patents involving SVOPL

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 QuantiFast Probe-based Assays in human, mouse, rat SVOPL QuantiTect SYBR Green Assays in human, mouse, rat SVOPL
 Custom PCR Arrays for SVOPL Search Chromatin IP Primers for SVOPL
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 GenScript Custom Purified and Recombinant Proteins Services for SVOPL GenScript cDNA clones with any tag delivered in your preferred vector for SVOPL
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 Search for Antibodies & Assays

 Search Tocris compounds for SVOPL
 Browse Sino Biological Proteins
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 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

 Novus Tissue Slides
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 Search for Antibodies for SVOPL at Abcam
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 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SVOPL
 SwitchGear 3'UTR luciferase reporter plasmids for SVOPL
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 Search ThermoFisher Antibodies for SVOPL
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SVOPL
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SVOPL
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 LSBio Antibodies in human, mouse, rat for SVOPL
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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