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Aliases for SVOPL Gene

Aliases for SVOPL Gene

  • SVOP Like 2 3 5
  • SV2 Related Protein Homolog (Rat)-Like 2
  • SV2-Related Protein-Like 4
  • SVOP-Like Protein 4
  • SVOP-Like 2

External Ids for SVOPL Gene

Previous GeneCards Identifiers for SVOPL Gene

  • GC07M137930
  • GC07M138279
  • GC07M132588

Summaries for SVOPL Gene

Entrez Gene Summary for SVOPL Gene

  • The protein encoded by this gene is thought to be a member of solute carrier family 22, which includes transmembrane proteins that transport toxins and drugs from the body. This gene is a paralog of the SVOP gene that encodes synaptic vesicle 2-related protein. [provided by RefSeq, Sep 2016]

GeneCards Summary for SVOPL Gene

SVOPL (SVOP Like) is a Protein Coding gene. GO annotations related to this gene include transmembrane transporter activity. An important paralog of this gene is SVOP.

Additional gene information for SVOPL Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SVOPL Gene

Genomics for SVOPL Gene

Regulatory Elements for SVOPL Gene

Enhancers for SVOPL Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07H138738 1.2 Ensembl ENCODE 10.8 -37.5 -37537 1 RB1 ARNT ZNF133 ARID4B ZNF2 RAD21 RFX5 YY1 ZNF143 RCOR1 SVOPL UQCRFS1P2 ENSG00000201465 TMEM213
GH07H138472 0.9 ENCODE dbSUPER 10.7 +228.8 228788 0 TFAP4 SAP130 ZNF384 RARA SSRP1 POLR2A PRDM1 SUPT5H SVOPL ENSG00000201465 UQCRFS1P2 TRIM24 RPS3AP28
GH07H138602 0.6 ENCODE 12.5 +97.7 97689 2 JUND CEBPA HNF4G CEBPG HNF4A KDM1A ENSG00000252188 SVOPL TRIM24 GC07M138626 RPS3AP28
GH07H138613 0.7 ENCODE 10.4 +87.0 86952 0 SOX13 ATF1 FOXA2 CEBPG ZNF384 RARA ZNF316 TRIM24 NFIA FOXA3 SVOPL UQCRFS1P2 GC07M138626 ENSG00000252188 RPS3AP28
GH07H138746 0.6 FANTOM5 11.8 -44.9 -44935 0 PKNOX1 ZNF316 POLR2A MAFG NFE2 EMSY MAFK SVOPL UQCRFS1P2 TMEM213
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SVOPL on UCSC Golden Path with GeneCards custom track

Genomic Location for SVOPL Gene

Chromosome:
7
Start:
138,594,285 bp from pter
End:
138,701,354 bp from pter
Size:
107,070 bases
Orientation:
Minus strand

Genomic View for SVOPL Gene

Genes around SVOPL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SVOPL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SVOPL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SVOPL Gene

Proteins for SVOPL Gene

  • Protein details for SVOPL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N434-SVOPL_HUMAN
    Recommended name:
    Putative transporter SVOPL
    Protein Accession:
    Q8N434

    Protein attributes for SVOPL Gene

    Size:
    492 amino acids
    Molecular mass:
    53991 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SVOPL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SVOPL Gene

Post-translational modifications for SVOPL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SVOPL Gene

Domains & Families for SVOPL Gene

Gene Families for SVOPL Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for SVOPL Gene

Suggested Antigen Peptide Sequences for SVOPL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N434

UniProtKB/Swiss-Prot:

SVOPL_HUMAN :
  • Belongs to the major facilitator superfamily.
Family:
  • Belongs to the major facilitator superfamily.
genes like me logo Genes that share domains with SVOPL: view

Function for SVOPL Gene

Phenotypes From GWAS Catalog for SVOPL Gene

Gene Ontology (GO) - Molecular Function for SVOPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0022857 transmembrane transporter activity IEA --
GO:0022891 substrate-specific transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with SVOPL: view
genes like me logo Genes that share phenotypes with SVOPL: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SVOPL

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SVOPL
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SVOPL Gene

Localization for SVOPL Gene

Subcellular locations from UniProtKB/Swiss-Prot for SVOPL Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SVOPL gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for SVOPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with SVOPL: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SVOPL Gene

Pathways & Interactions for SVOPL Gene

SuperPathways for SVOPL Gene

No Data Available

Interacting Proteins for SVOPL Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000405482%0d%0a9606.ENSP00000311505%0d%0a
Selected Interacting proteins: Q8N434-SVOPL_HUMAN ENSP00000405482 for SVOPL Gene via IID STRING

Gene Ontology (GO) - Biological Process for SVOPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SVOPL: view

No data available for Pathways by source and SIGNOR curated interactions for SVOPL Gene

Drugs & Compounds for SVOPL Gene

No Compound Related Data Available

Transcripts for SVOPL Gene

mRNA/cDNA for SVOPL Gene

Unigene Clusters for SVOPL Gene

SVOP-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SVOPL
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SVOPL Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12
SP1: - -
SP2:

Relevant External Links for SVOPL Gene

GeneLoc Exon Structure for
SVOPL
ECgene alternative splicing isoforms for
SVOPL

Expression for SVOPL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SVOPL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SVOPL Gene

This gene is overexpressed in Testis (x8.2) and Kidney - Cortex (x7.8).

NURSA nuclear receptor signaling pathways regulating expression of SVOPL Gene:

SVOPL

SOURCE GeneReport for Unigene cluster for SVOPL Gene:

Hs.99414
genes like me logo Genes that share expression patterns with SVOPL: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SVOPL Gene

Orthologs for SVOPL Gene

This gene was present in the common ancestor of chordates.

Orthologs for SVOPL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SVOPL 33 34
  • 99.32 (n)
oppossum
(Monodelphis domestica)
Mammalia SVOPL 34
  • 90 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SVOPL 33 34
  • 88.89 (n)
dog
(Canis familiaris)
Mammalia SVOPL 33 34
  • 88.07 (n)
mouse
(Mus musculus)
Mammalia Svopl 33 16 34
  • 87.53 (n)
rat
(Rattus norvegicus)
Mammalia RGD1566053 33
  • 84.66 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SVOPL 34
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves SVOPL 33 34
  • 76.94 (n)
lizard
(Anolis carolinensis)
Reptilia SVOPL 34
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia svopl 33
  • 69.74 (n)
zebrafish
(Danio rerio)
Actinopterygii svopl 33 34
  • 60 (n)
Species where no ortholog for SVOPL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SVOPL Gene

ENSEMBL:
Gene Tree for SVOPL (if available)
TreeFam:
Gene Tree for SVOPL (if available)

Paralogs for SVOPL Gene

Paralogs for SVOPL Gene

(2) SIMAP similar genes for SVOPL Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SVOPL: view

Variants for SVOPL Gene

Sequence variations from dbSNP and Humsavar for SVOPL Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000006050 -- 138,632,726(+) AGGGA(-/GGATGGGGGC)GGATG intron-variant
rs1000019503 -- 138,642,016(+) AAGTC(C/T)CTATA intron-variant
rs1000044598 -- 138,670,063(+) AGCCC(C/T)TTTGA intron-variant
rs1000044720 -- 138,626,241(+) CCACT(A/G)CCTTC intron-variant
rs1000050144 -- 138,676,905(+) TTTTT(A/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SVOPL Gene

Variant ID Type Subtype PubMed ID
esv1010083 CNV deletion 20482838
esv1471021 CNV deletion 17803354
esv2543778 CNV deletion 19546169
esv2657210 CNV deletion 23128226
esv2659373 CNV deletion 23128226
esv2678647 CNV deletion 23128226
esv2735212 CNV deletion 23290073
esv2735218 CNV deletion 23290073
esv2735219 CNV deletion 23290073
esv2735220 CNV deletion 23290073
esv2735221 CNV deletion 23290073
esv2735222 CNV deletion 23290073
esv3359 CNV loss 18987735
esv3438653 CNV duplication 20981092
esv3542504 CNV deletion 23714750
esv3542505 CNV deletion 23714750
esv3542506 CNV deletion 23714750
esv3542507 CNV deletion 23714750
esv3615196 CNV loss 21293372
esv3615197 CNV loss 21293372
esv6486 CNV loss 19470904
esv7121 CNV loss 19470904
esv993410 CNV deletion 20482838
nsv1030956 CNV gain 25217958
nsv1076002 CNV deletion 25765185
nsv1076954 CNV deletion 25765185
nsv1109920 CNV deletion 24896259
nsv1112160 CNV deletion 24896259
nsv1119138 CNV deletion 24896259
nsv1120922 CNV deletion 24896259
nsv1140852 CNV deletion 24896259
nsv365934 CNV deletion 16902084
nsv512927 CNV insertion 21212237
nsv512928 CNV insertion 21212237
nsv5968 CNV insertion 18451855
nsv956979 CNV deletion 24416366
nsv970584 CNV duplication 23825009

Variation tolerance for SVOPL Gene

Residual Variation Intolerance Score: 97.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.47; 96.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SVOPL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SVOPL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SVOPL Gene

Disorders for SVOPL Gene

Relevant External Links for SVOPL

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SVOPL

No disorders were found for SVOPL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SVOPL Gene

Publications for SVOPL Gene

  1. Identification of six putative human transporters with structural similarity to the drug transporter SLC22 family. (PMID: 17714910) Jacobsson JA … Fredriksson R (Genomics 2007) 3 4 60
  2. Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. (PMID: 21565611) Sang L … Jackson PK (Cell 2011) 3 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 60
  4. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 4 60
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60

Products for SVOPL Gene

Sources for SVOPL Gene

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