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Aliases for SVOPL Gene

Aliases for SVOPL Gene

  • SVOP-Like 2 3
  • SV2 Related Protein Homolog (Rat)-Like 2
  • SV2-Related Protein-Like 4
  • SVOP-Like Protein 4

External Ids for SVOPL Gene

Summaries for SVOPL Gene

GeneCards Summary for SVOPL Gene

SVOPL (SVOP-Like) is a Protein Coding gene. GO annotations related to this gene include transmembrane transporter activity. An important paralog of this gene is SV2C.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SVOPL Gene

Genomics for SVOPL Gene

Genomic Location for SVOPL Gene

Start:
138,594,285 bp from pter
End:
138,701,352 bp from pter
Size:
107,068 bases
Orientation:
Minus strand

Genomic View for SVOPL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SVOPL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SVOPL Gene

Regulatory Elements for SVOPL Gene

Proteins for SVOPL Gene

  • Protein details for SVOPL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N434-SVOPL_HUMAN
    Recommended name:
    Putative transporter SVOPL
    Protein Accession:
    Q8N434
    Secondary Accessions:

    Protein attributes for SVOPL Gene

    Size:
    492 amino acids
    Molecular mass:
    53991 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SVOPL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SVOPL Gene

Proteomics data for SVOPL Gene at MOPED

Post-translational modifications for SVOPL Gene

No Post-translational modifications

Other Protein References for SVOPL Gene

No data available for DME Specific Peptides for SVOPL Gene

Domains for SVOPL Gene

Protein Domains for SVOPL Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

SVOPL_HUMAN
Family:
  • Belongs to the major facilitator superfamily.:
    • Q8N434
genes like me logo Genes that share domains with SVOPL: view

No data available for Gene Families for SVOPL Gene

Function for SVOPL Gene

Gene Ontology (GO) - Molecular Function for SVOPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0022857 transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SVOPL: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SVOPL Gene

Localization for SVOPL Gene

Subcellular locations from UniProtKB/Swiss-Prot for SVOPL Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SVOPL Gene COMPARTMENTS Subcellular localization image for SVOPL gene
Compartment Confidence
plasma membrane 3
nucleus 1

Gene Ontology (GO) - Cellular Components for SVOPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SVOPL: view

Pathways for SVOPL Gene

SuperPathways for SVOPL Gene

No Data Available

Interacting Proteins for SVOPL Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000405482%0d%0a9606.ENSP00000311505%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000405482 for SVOPL Gene via STRING

Gene Ontology (GO) - Biological Process for SVOPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SVOPL: view

No data available for Pathways by source for SVOPL Gene

Transcripts for SVOPL Gene

mRNA/cDNA for SVOPL Gene

(5) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SVOPL Gene

SVOP-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SVOPL Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12
SP1: - -
SP2:

Relevant External Links for SVOPL Gene

GeneLoc Exon Structure for
SVOPL
ECgene alternative splicing isoforms for
SVOPL

Expression for SVOPL Gene

mRNA expression in normal human tissues for SVOPL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SVOPL Gene

This gene is overexpressed in Testis (8.2) and Kidney - Cortex (7.8).

SOURCE GeneReport for Unigene cluster for SVOPL Gene Hs.99414

genes like me logo Genes that share expressions with SVOPL: view

Orthologs for SVOPL Gene

This gene was present in the common ancestor of chordates.

Orthologs for SVOPL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SVOPL 36
  • 99.32 (n)
  • 98.98 (a)
SVOPL 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SVOPL 36
  • 88.89 (n)
  • 92.89 (a)
SVOPL 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SVOPL 36
  • 88.07 (n)
  • 92.39 (a)
SVOPL 37
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Svopl 36
  • 87.53 (n)
  • 92.07 (a)
Svopl 16
Svopl 37
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SVOPL 37
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SVOPL 37
  • 66 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1566053 36
  • 84.66 (n)
  • 89.16 (a)
chicken
(Gallus gallus)
Aves SVOPL 36
  • 76.94 (n)
  • 83.88 (a)
SVOPL 37
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SVOPL 37
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia svopl 36
  • 69.74 (n)
  • 74.9 (a)
zebrafish
(Danio rerio)
Actinopterygii svopl 36
  • 60 (n)
  • 56.77 (a)
svopl 37
  • 52 (a)
OneToOne
Species with no ortholog for SVOPL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SVOPL Gene

ENSEMBL:
Gene Tree for SVOPL (if available)
TreeFam:
Gene Tree for SVOPL (if available)

Paralogs for SVOPL Gene

Paralogs for SVOPL Gene

Selected SIMAP similar genes for SVOPL Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SVOPL: view

Variants for SVOPL Gene

Sequence variations from dbSNP and Humsavar for SVOPL Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs296912 -- 138,691,082(+) aattg(C/T)actct intron-variant
rs296913 -- 138,691,439(+) GGGCA(A/C)TAAAA intron-variant
rs296914 -- 138,691,673(+) gaagc(C/T)gggat intron-variant
rs296915 -- 138,691,913(+) CCCAG(G/T)TTCCA intron-variant
rs296916 -- 138,692,199(+) CTTAT(C/G)AGTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SVOPL Gene

Variant ID Type Subtype PubMed ID
esv2735212 CNV Deletion 23290073
nsv5968 CNV Insertion 18451855
esv993410 CNV Deletion 20482838
esv2735218 CNV Deletion 23290073
esv3359 CNV Deletion 18987735
esv7121 CNV Loss 19470904
esv1010083 CNV Deletion 20482838
nsv512927 CNV Insertion 21212237
esv2735219 CNV Deletion 23290073
esv2657210 CNV Deletion 23128226
esv1471021 CNV Deletion 17803354
esv6486 CNV Loss 19470904
esv2543778 CNV Deletion 19546169
esv2735220 CNV Deletion 23290073
esv2735221 CNV Deletion 23290073
esv2735222 CNV Deletion 23290073
nsv365934 CNV Loss 16902084
nsv512928 CNV Insertion 21212237
esv2678647 CNV Deletion 23128226
esv2659373 CNV Deletion 23128226

Relevant External Links for SVOPL Gene

HapMap Linkage Disequilibrium report
SVOPL

Disorders for SVOPL Gene

No disorders were found for SVOPL Gene.

No data available for UniProtKB/Swiss-Prot for SVOPL Gene

Publications for SVOPL Gene

  1. Identification of six putative human transporters with structural similarity to the drug transporter SLC22 family. (PMID: 17714910) Jacobsson J.A. … Fredriksson R. (Genomics 2007) 3 4
  2. Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. (PMID: 21565611) Sang L. … Jackson P.K. (Cell 2011) 3
  3. Global identification of modular cullin-RING ligase substrates. (PMID: 21963094) Emanuele M.J. … Elledge S.J. (Cell 2011) 3
  4. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for SVOPL Gene

Sources for SVOPL Gene

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