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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SVOPL Gene

protein-coding   GIFtS: 44
GCID: GC07M138279

SVOP-like

(Previous name: SV2 related protein homolog (rat)-like )
  Search for SVOPL
in our new
 Human Malady Compendium 
Biological research products
for SVOPL
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
SVOP-Like1     SV2 Related Protein Homolog (Rat)-Like1
SV2-Related Protein-Like2 3     Putative Transporter SVOPL2
SVOP-Like Protein2 3     SV2 Related Protein Homolog-Like2
MGC467151     

External Ids:    HGNC: 270341   Entrez Gene: 1363062   Ensembl: ENSG000001577037   OMIM: 6117005   UniProtKB: Q8N4343   

Export aliases for SVOPL gene to outside databases

Previous GC identifers: GC07M137930 GC07M132588


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007933.15  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SVOPL gene promoter:
         AP-2beta   ITF-2   Tal-1beta   AP-2alpha   AP-2gamma   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSVOPL promoter sequence
   Search SABiosciences Chromatin IP Primers for SVOPL

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SVOPL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q34   Ensembl cytogenetic band:  7q34   HGNC cytogenetic band: 7q34

SVOPL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SVOPL gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M138279:  view genomic region     (about GC identifiers)

Start:
138,279,030 bp from pter      End:
138,386,097 bp from pter
Size:
107,068 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 137,624,061-137,707,981     

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SVOPL_HUMAN, Q8N434 (See protein sequence)
Recommended Name: Putative transporter SVOPL  
Size: 492 amino acids; 53991 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Alternative splicing: 2 isoforms:  Q8N434-1   Q8N434-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SVOPL: NX_Q8N434

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8N434

  • SVOPL Protein expression data from MOPED and PaxDb:    About this image 
    SVOPL Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001132928.1  NP_777619.1  

    ENSEMBL proteins: 
     ENSP00000288513   ENSP00000393487   ENSP00000412830   ENSP00000405482   ENSP00000417018  

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    Uscn Proteins for SVOPL

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    SVOPL for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    SVOPL for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR005828 Sub_transporter
     IPR020846 MFS_dom
     IPR011701 MFS
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry Q8N434

    ProtoNet protein and cluster: Q8N434

    UniProtKB/Swiss-Prot: SVOPL_HUMAN, Q8N434
    Similarity: Belongs to the major facilitator superfamily


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0022857transmembrane transporter activity IEA--
         
    SVOPL for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SVOPL 

    miRNA
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SVOPL

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for SVOPL (ENSP000004054824) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IQCB1ENSP000003115054STRING: ENSP00000311505
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SVOPL
    Search CenterWatch for drugs/clinical trials and news about SVOPL 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SVOPL gene (2 alternative transcripts): 
    NM_001139456.1  NM_174959.2  

    Unigene Cluster for SVOPL:

    SVOP-like
    Hs.99414  [show with all ESTs]
    Unigene Representative Sequence: BX648789
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000288513 ENST00000441685(uc011kqh.2) ENST00000421622 ENST00000478865
    ENST00000463557 ENST00000419765 ENST00000436657(uc003vue.3)

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate SVOPL:
    hsa-miR-664
    SwitchGear 3'UTR luciferase reporter plasmidSVOPL 3' UTR sequence
    Inhib. RNA
    Products:
         
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SVOPL (see all 4)
    OriGene shRNA RFP: SVOPL
    OriGene siRNA: SVOPL
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    Sirion Biotech Custom design and validation of potent shRNA sequences against SVOPL 
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): SVOPL (NM_001139456)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SVOPL 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SVOPL
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SVOPL

    Additional cDNA sequence: 

    BC036796.1 BX648789.1 

    3 DOTS entries:

    DT.91895063  DT.97774923  DT.100735258 

    12 AceView cDNA sequences:

    BF939622 AL704123 BX349158 BC036796 AA455897 AA455898 BX648789 NM_174959 
    BX106936 BX401218 BM906451 AV743859 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for SVOPL    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12
    SP1:        -                                                     -               
    SP2:                                                                              


    ECgene alternative splicing isoforms for SVOPL

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SVOPL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTGTCAGGAC
    SVOPL Expression
    About this image

    SVOPL expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    6 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    OvaryAntral FollicleSecondary OocyteFemale Gametocytes, Germ Cells
    BoneZeugopod Epiphyseal EndBone
    BoneZeugopod Growth PlateBone
    KidneyEpithelial TubuleKidney
    KidneyMetanephrosKidney
    KidneyRenal VesicleKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SVOPL Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SVOPL

    SOURCE GeneReport for Unigene cluster: Hs.99414
        SABiosciences Custom PCR Arrays for SVOPL
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SVOPL
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SVOPL

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for SVOPL gene from 6/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves SVOPL1 SVOP-like 76.93(n)
    83.98(a)
      418105  XM_416339.3  XP_416339.3 
    lizard
    (Anolis carolinensis)
    Reptilia SVOPL6
    --
    83(a)
    1 ↔ 1
    5(14923847-14941892)
    zebrafish
    (Danio rerio)
    Actinopterygii svopl1 SVOP-like 59.97(n)
    56.59(a)
      492766  NM_001045229.1  NP_001038694.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G130506
    major facilitator protein
    29(a)
    1 → many
    3(4176511-4179066)
    rice
    (Oryza sativa)
    Liliopsida --
    --
    (see all 4)
    transporter family protein, putative, expressed
    (see all 4)
    29(a)
    29(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    3(24447214-24452023)
    9(22238918-22243013)
    E. coli
    (Escherichia coli)
    Gamma proteobacteria ygcS6
    ydjE6
    (see all 7)
    predicted transporter
    (see all 7)
    20(a)
    19(a)
    (see all 7)
    possible ortholog
    possible ortholog
    (see all 7)
    Chromosome(2894555-2895892)
    Chromosome(1850645-1852003)


    ENSEMBL Gene Tree for SVOPL (if available)
    TreeFam Gene Tree for SVOPL (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SVOPL gene
    SV2B2  SV2C2  SV2A2  SVOP2  
    2 SIMAP similar genes for SVOPL using alignment to 3 protein entries:     SVOPL_HUMAN (see all proteins):
    SLC22A7    SVOP

    SVOPL for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2109 NCBI SNPs in SVOPL are shown (see all 2109    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1438340291,2
    --138278590(+) ATCACC/TATAAC 2 -- ds50010--------
    rs747992761,2
    C,F--138278702(+) ATGGCG/AGAAAG 2 -- ds50014Minor allele frequency- A:0.07NA CSA WA 242
    rs1813726721,2
    --138278750(+) GATTCC/TCCCTA 2 -- ds50010--------
    rs1442820841,2
    --138278834(+) GTAAT-/ACTC  
            
    ACTCT
    2 -- ds50010--------
    rs16163181,2
    C,F,A,H--138278913(-) CAAATT/CCAAAT 2 -- ds500127Minor allele frequency- C:0.29NA NS EA WA CSA 2491
    rs1481630171,2
    --138278963(+) CCCAGG/TTTCTT 2 -- ds50010--------
    rs1856957481,2
    --138278997(+) CAAGTG/TTAGCT 2 -- ds50010--------
    rs1909455481,2
    --138279033(+) TGTAAG/TTTTAA 2 -- ut310--------
    rs1809424121,2
    --138279062(+) ATAAAA/GGTTTA 2 -- ut310--------
    rs16146411,2
    C,F,H--138279083(-) TCTTCG/ATTGAA 2 -- ut3120Minor allele frequency- A:0.33MN EA NA NS WA CSA 1190

    HapMap Linkage Disequilibrium report for SVOPL (138279030 - 138386097 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 6 variations for SVOPL
         2 CNVs: 62731 100144
         4 Indels: 28462 41031 62732 43177

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SVOPL for disorders           About MalaCards

    SVOPL for disorders           About GeneDecksing

    OMIM gene information: 611700    OMIM disorders: --


    Export disorders for SVOPL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SVOPL gene integrated from 9 sources:
    (articles sorted by number of sources associating them with SVOPL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of six putative human transporters with structural similarity to the drug transporter SLC22 family. (PubMed id 17714910)1, 2 Jacobsson J.A.... Fredriksson R. (2007)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    3. The DNA sequence of human chromosome 7. (PubMed id 12853948)2 Hillier L.W.... Wilson R.K. (2003)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 136306 HGNC: 27034 AceView: LOC136306 Ensembl:ENSG00000157703 euGenes: HUgn136306
    ECgene: SVOPL H-InvDB: SVOPL

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SVOPL Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SVOPL gene:
    Search GeneIP for patents involving SVOPL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     
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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

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    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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