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Aliases for SVOP Gene

Aliases for SVOP Gene

  • SV2 Related Protein 2 3 5
  • SV2 Related Protein Homolog (Rat) 2
  • SV2-Related Protein 4

External Ids for SVOP Gene

Previous GeneCards Identifiers for SVOP Gene

  • GC12M107808
  • GC12M109304
  • GC12M106369

Summaries for SVOP Gene

GeneCards Summary for SVOP Gene

SVOP (SV2 Related Protein) is a Protein Coding gene. GO annotations related to this gene include transmembrane transporter activity and ion transmembrane transporter activity. An important paralog of this gene is SV2C.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SVOP Gene

Genomics for SVOP Gene

Genomic Location for SVOP Gene

Chromosome:
12
Start:
108,907,741 bp from pter
End:
109,021,240 bp from pter
Size:
113,500 bases
Orientation:
Minus strand

Genomic View for SVOP Gene

Genes around SVOP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SVOP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SVOP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SVOP Gene

No data available for Regulatory Elements for SVOP Gene

Proteins for SVOP Gene

  • Protein details for SVOP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N4V2-SVOP_HUMAN
    Recommended name:
    Synaptic vesicle 2-related protein
    Protein Accession:
    Q8N4V2
    Secondary Accessions:
    • Q9NPW5

    Protein attributes for SVOP Gene

    Size:
    548 amino acids
    Molecular mass:
    60769 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SVOP Gene

Proteomics data for SVOP Gene at MOPED

Post-translational modifications for SVOP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SVOP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SVOP Gene

Domains & Families for SVOP Gene

Protein Domains for SVOP Gene

Suggested Antigen Peptide Sequences for SVOP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N4V2

UniProtKB/Swiss-Prot:

SVOP_HUMAN :
  • Belongs to the major facilitator superfamily.
Family:
  • Belongs to the major facilitator superfamily.
genes like me logo Genes that share domains with SVOP: view

No data available for Gene Families for SVOP Gene

Function for SVOP Gene

genes like me logo Genes that share phenotypes with SVOP: view

Animal Models for SVOP Gene

MGI Knock Outs for SVOP:

Animal Model Products

  • Taconic Biosciences Mouse Models for SVOP

miRNA for SVOP Gene

miRTarBase miRNAs that target SVOP

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SVOP Gene

Localization for SVOP Gene

Subcellular locations from UniProtKB/Swiss-Prot for SVOP Gene

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SVOP Gene COMPARTMENTS Subcellular localization image for SVOP gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for SVOP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008021 synaptic vesicle ISS --
GO:0030054 cell junction IEA --
GO:0030672 synaptic vesicle membrane IEA --
genes like me logo Genes that share ontologies with SVOP: view

Pathways & Interactions for SVOP Gene

SuperPathways for SVOP Gene

No Data Available

Interacting Proteins for SVOP Gene

Gene Ontology (GO) - Biological Process for SVOP Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SVOP Gene

Drugs & Compounds for SVOP Gene

No Compound Related Data Available

Transcripts for SVOP Gene

Unigene Clusters for SVOP Gene

SV2 related protein homolog (rat):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SVOP Gene

No ASD Table

Relevant External Links for SVOP Gene

GeneLoc Exon Structure for
SVOP
ECgene alternative splicing isoforms for
SVOP

Expression for SVOP Gene

mRNA expression in normal human tissues for SVOP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SVOP Gene

This gene is overexpressed in Brain - Cortex (x8.3), Brain - Frontal Cortex (BA9) (x6.6), and Brain - Anterior cingulate cortex (BA24) (x6.5).

Protein differential expression in normal tissues from HIPED for SVOP Gene

This gene is overexpressed in Retina (26.6), Fetal Brain (25.3), and Frontal cortex (17.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SVOP Gene



SOURCE GeneReport for Unigene cluster for SVOP Gene Hs.4221

genes like me logo Genes that share expression patterns with SVOP: view

Protein tissue co-expression partners for SVOP Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for SVOP Gene

Orthologs for SVOP Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SVOP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SVOP 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SVOP 36
  • 87 (a)
OneToOne
SVOP 35
  • 92.09 (n)
  • 98.54 (a)
dog
(Canis familiaris)
Mammalia SVOP 35
  • 92.09 (n)
  • 97.99 (a)
SVOP 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Svop 16
Svop 36
  • 84 (a)
OneToOne
Svop 35
  • 88.5 (n)
  • 95.62 (a)
oppossum
(Monodelphis domestica)
Mammalia SVOP 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SVOP 36
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Svop 35
  • 87.71 (n)
  • 95.8 (a)
chicken
(Gallus gallus)
Aves SVOP 35
  • 80.05 (n)
  • 92.7 (a)
SVOP 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SVOP 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia svop 35
  • 76.82 (n)
  • 88.32 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.259 35
zebrafish
(Danio rerio)
Actinopterygii svopa 36
  • 70 (a)
OneToOne
svopa 35
  • 71.47 (n)
  • 78.28 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007660 35
  • 55.56 (n)
  • 53.76 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4324 36
  • 47 (a)
OneToOne
CG4324 35
  • 55.03 (n)
  • 51.47 (a)
worm
(Caenorhabditis elegans)
Secernentea svop-1 35
  • 54.88 (n)
  • 55.65 (a)
svop-1 36
  • 49 (a)
OneToOne
rice
(Oryza sativa)
Liliopsida Os03g0638200 35
  • 48.15 (n)
  • 40.14 (a)
Species with no ortholog for SVOP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SVOP Gene

ENSEMBL:
Gene Tree for SVOP (if available)
TreeFam:
Gene Tree for SVOP (if available)

Paralogs for SVOP Gene

Paralogs for SVOP Gene

(7) SIMAP similar genes for SVOP Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SVOP: view

Variants for SVOP Gene

Sequence variations from dbSNP and Humsavar for SVOP Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1141183 -- 108,963,562(+) agctc(A/G)ctgca intron-variant
rs3059703 -- 109,018,132(+) tgaat(-/GAAT)CGATC intron-variant
rs4075292 -- 108,943,637(-) TATGG(A/G)CCTGT intron-variant
rs4132529 -- 108,966,350(-) GTGAA(A/G)GAAAC intron-variant
rs4514476 -- 108,925,866(-) atagg(A/T)tggtc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SVOP Gene

Variant ID Type Subtype PubMed ID
esv2422361 CNV Duplication 17116639
nsv455711 CNV Loss 19166990
esv6912 CNV Loss 19470904
esv270200 CNV Insertion 20981092
esv1008019 CNV Loss 20482838
nsv525664 CNV Loss 19592680

Relevant External Links for SVOP Gene

HapMap Linkage Disequilibrium report
SVOP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for SVOP Gene

Disorders for SVOP Gene

Relevant External Links for SVOP

Genetic Association Database (GAD)
SVOP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SVOP

No disorders were found for SVOP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SVOP Gene

Publications for SVOP Gene

  1. SVOP is a nucleotide binding protein. (PMID: 19390693) Yao J. … Bajjalieh S.M. (PLoS ONE 2009) 2 3 23 67
  2. Comparative genomics and functional analysis of the NiaP family uncover nicotinate transporters from bacteria, plants, and mammals. (PMID: 21953179) Jeanguenin L. … Hanson A.D. (Funct. Integr. Genomics 2012) 2 3
  3. SVOP, an evolutionarily conserved synaptic vesicle protein, suggests novel transport functions of synaptic vesicles. (PMID: 9801366) Janz R. … SA1dhof T.C. (J. Neurosci. 1998) 2 3
  4. The identification of novel proteins that interact with the GLP-1 receptor and restrain its activity. (PMID: 23864651) Huang X. … Wheeler M.B. (Mol. Endocrinol. 2013) 3
  5. Identification of six putative human transporters with structural similarity to the drug transporter SLC22 family. (PMID: 17714910) Jacobsson J.A. … Fredriksson R. (Genomics 2007) 3

Products for SVOP Gene

Sources for SVOP Gene

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