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Aliases for SVOP Gene

Aliases for SVOP Gene

  • SV2 Related Protein 2 3 5
  • SV2 Related Protein Homolog (Rat) 2
  • SV2-Related Protein 4

External Ids for SVOP Gene

Previous GeneCards Identifiers for SVOP Gene

  • GC12M107808
  • GC12M109304
  • GC12M106369

Summaries for SVOP Gene

GeneCards Summary for SVOP Gene

SVOP (SV2 Related Protein) is a Protein Coding gene. GO annotations related to this gene include transmembrane transporter activity and ion transmembrane transporter activity. An important paralog of this gene is SVOPL.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SVOP Gene

Genomics for SVOP Gene

Regulatory Elements for SVOP Gene

Enhancers for SVOP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G108911 0.8 ENCODE 13.8 +109.3 109300 1.4 FOXA2 ZNF493 KLF17 INSM2 RAD21 ELK1 ZSCAN5C FOS KLF7 ZNF362 SVOP GC12M108908 GC12P108919
GH12G108913 0.8 Ensembl ENCODE 5.4 +107.0 106960 1.0 OSR2 RING1 RNF2 BMI1 EZH2 ZBTB20 SART3 SVOP GC12P108919 GC12M108908
GH12G108906 1.3 FANTOM5 Ensembl ENCODE 3.1 +113.4 113369 2.6 CTCF KLF1 PKNOX1 ZSCAN26 TEAD4 ZMYM3 NFXL1 TEAD3 ZFHX2 GATA3 ALKBH2 SART3 USP30 DAO SVOP GC12M108908 PIR41002 GC12M108869
GH12G108966 0.4 ENCODE 4.8 +54.5 54452 0.8 NFE2 MYO1H USP30 SVOP GC12P108965 GC12M108978
GH12G109020 1.3 Ensembl ENCODE 0.7 +0.3 265 0.6 MLX ARID4B SIN3A ZNF2 SLC30A9 ZNF766 ZNF143 FOS ZNF263 SP3 SVOP ENSG00000279630 LOC105378256
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SVOP on UCSC Golden Path with GeneCards custom track

Genomic Location for SVOP Gene

Chromosome:
12
Start:
108,907,741 bp from pter
End:
109,021,240 bp from pter
Size:
113,500 bases
Orientation:
Minus strand

Genomic View for SVOP Gene

Genes around SVOP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SVOP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SVOP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SVOP Gene

Proteins for SVOP Gene

  • Protein details for SVOP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N4V2-SVOP_HUMAN
    Recommended name:
    Synaptic vesicle 2-related protein
    Protein Accession:
    Q8N4V2
    Secondary Accessions:
    • Q9NPW5

    Protein attributes for SVOP Gene

    Size:
    548 amino acids
    Molecular mass:
    60769 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SVOP Gene

Post-translational modifications for SVOP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SVOP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SVOP Gene

Domains & Families for SVOP Gene

Protein Domains for SVOP Gene

Suggested Antigen Peptide Sequences for SVOP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N4V2

UniProtKB/Swiss-Prot:

SVOP_HUMAN :
  • Belongs to the major facilitator superfamily.
Family:
  • Belongs to the major facilitator superfamily.
genes like me logo Genes that share domains with SVOP: view

No data available for Gene Families for SVOP Gene

Function for SVOP Gene

Gene Ontology (GO) - Molecular Function for SVOP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0022857 transmembrane transporter activity IEA --
GO:0022891 substrate-specific transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with SVOP: view
genes like me logo Genes that share phenotypes with SVOP: view

Animal Models for SVOP Gene

MGI Knock Outs for SVOP:

Animal Model Products

  • Taconic Biosciences Mouse Models for SVOP

CRISPR Products

miRNA for SVOP Gene

miRTarBase miRNAs that target SVOP

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SVOP Gene

Localization for SVOP Gene

Subcellular locations from UniProtKB/Swiss-Prot for SVOP Gene

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SVOP gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for SVOP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008021 synaptic vesicle ISS,IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,IBA --
GO:0030054 cell junction IEA --
GO:0030672 synaptic vesicle membrane IEA --
genes like me logo Genes that share ontologies with SVOP: view

Pathways & Interactions for SVOP Gene

No Data Available

Interacting Proteins for SVOP Gene

Selected Interacting proteins: Q8N4V2-SVOP_HUMAN for SVOP Gene via IID

Gene Ontology (GO) - Biological Process for SVOP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SVOP: view

No data available for Pathways by source and SIGNOR curated interactions for SVOP Gene

Drugs & Compounds for SVOP Gene

No Compound Related Data Available

Transcripts for SVOP Gene

Unigene Clusters for SVOP Gene

SV2 related protein homolog (rat):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SVOP Gene

No ASD Table

Relevant External Links for SVOP Gene

GeneLoc Exon Structure for
SVOP
ECgene alternative splicing isoforms for
SVOP

Expression for SVOP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SVOP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SVOP Gene

This gene is overexpressed in Brain - Cortex (x8.3), Brain - Frontal Cortex (BA9) (x6.6), and Brain - Anterior cingulate cortex (BA24) (x6.5).

Protein differential expression in normal tissues from HIPED for SVOP Gene

This gene is overexpressed in Retina (26.6), Fetal Brain (25.3), and Frontal cortex (17.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SVOP Gene



Protein tissue co-expression partners for SVOP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SVOP Gene:

SVOP

SOURCE GeneReport for Unigene cluster for SVOP Gene:

Hs.4221

Evidence on tissue expression from TISSUES for SVOP Gene

  • Nervous system(5)
genes like me logo Genes that share expression patterns with SVOP: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SVOP Gene

Orthologs for SVOP Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SVOP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SVOP 35
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SVOP 35
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SVOP 34 35
  • 92.09 (n)
dog
(Canis familiaris)
Mammalia SVOP 34 35
  • 92.09 (n)
mouse
(Mus musculus)
Mammalia Svop 34 16 35
  • 88.5 (n)
rat
(Rattus norvegicus)
Mammalia Svop 34
  • 87.71 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SVOP 35
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves SVOP 34 35
  • 80.05 (n)
lizard
(Anolis carolinensis)
Reptilia SVOP 35
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia svop 34
  • 76.82 (n)
zebrafish
(Danio rerio)
Actinopterygii svopa 34 35
  • 71.47 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.259 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007660 34
  • 55.56 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG4324 34 35
  • 55.03 (n)
worm
(Caenorhabditis elegans)
Secernentea svop-1 34 35
  • 54.88 (n)
rice
(Oryza sativa)
Liliopsida Os03g0638200 34
  • 48.15 (n)
Species where no ortholog for SVOP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SVOP Gene

ENSEMBL:
Gene Tree for SVOP (if available)
TreeFam:
Gene Tree for SVOP (if available)

Paralogs for SVOP Gene

Paralogs for SVOP Gene

(7) SIMAP similar genes for SVOP Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SVOP: view

Variants for SVOP Gene

Sequence variations from dbSNP and Humsavar for SVOP Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000002660 -- 108,936,852(+) TTTCT(C/T)TTTAA intron-variant
rs1000036822 -- 108,936,583(+) TGATC(C/T)TCCCA intron-variant
rs1000053015 -- 108,939,434(+) AGTTC(A/G)AGAGA intron-variant
rs1000082911 -- 108,981,480(+) CCATC(A/G)GCAAC intron-variant
rs1000123028 -- 108,973,506(+) CTCAC(C/T)TCAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SVOP Gene

Variant ID Type Subtype PubMed ID
esv1008019 CNV loss 20482838
esv2422361 CNV duplication 17116639
esv3449316 CNV insertion 20981092
esv3630711 CNV gain 21293372
esv6912 CNV loss 19470904
nsv1115437 CNV duplication 24896259
nsv1119983 CNV deletion 24896259
nsv1138167 CNV deletion 24896259
nsv455711 CNV loss 19166990
nsv473460 CNV novel sequence insertion 20440878
nsv473750 CNV novel sequence insertion 20440878
nsv473787 CNV novel sequence insertion 20440878
nsv474121 CNV novel sequence insertion 20440878
nsv475148 CNV novel sequence insertion 20440878
nsv475455 CNV novel sequence insertion 20440878
nsv475880 CNV novel sequence insertion 20440878
nsv476008 CNV novel sequence insertion 20440878
nsv477133 CNV novel sequence insertion 20440878
nsv477368 CNV novel sequence insertion 20440878
nsv478991 CNV novel sequence insertion 20440878
nsv479049 CNV novel sequence insertion 20440878
nsv479675 CNV novel sequence insertion 20440878
nsv479755 CNV novel sequence insertion 20440878
nsv479856 CNV novel sequence insertion 20440878
nsv479892 CNV novel sequence insertion 20440878
nsv480221 CNV novel sequence insertion 20440878
nsv480371 CNV novel sequence insertion 20440878
nsv480648 CNV novel sequence insertion 20440878
nsv480875 CNV novel sequence insertion 20440878
nsv480920 CNV novel sequence insertion 20440878
nsv481116 CNV novel sequence insertion 20440878
nsv481157 CNV novel sequence insertion 20440878
nsv481390 CNV novel sequence insertion 20440878
nsv525664 CNV loss 19592680
nsv560115 CNV loss 21841781

Relevant External Links for SVOP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SVOP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for SVOP Gene

Disorders for SVOP Gene

Relevant External Links for SVOP

Genetic Association Database (GAD)
SVOP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SVOP

No disorders were found for SVOP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SVOP Gene

Publications for SVOP Gene

  1. SVOP is a nucleotide binding protein. (PMID: 19390693) Yao J. … Bajjalieh S.M. (PLoS ONE 2009) 2 3 22 64
  2. Comparative genomics and functional analysis of the NiaP family uncover nicotinate transporters from bacteria, plants, and mammals. (PMID: 21953179) Jeanguenin L. … Hanson A.D. (Funct. Integr. Genomics 2012) 2 3 64
  3. Identification of six putative human transporters with structural similarity to the drug transporter SLC22 family. (PMID: 17714910) Jacobsson J.A. … Fredriksson R. (Genomics 2007) 3 4 64
  4. SVOP, an evolutionarily conserved synaptic vesicle protein, suggests novel transport functions of synaptic vesicles. (PMID: 9801366) Janz R. … SA1dhof T.C. (J. Neurosci. 1998) 2 3 64
  5. SR protein kinases promote splicing of nonconsensus introns. (PMID: 26167880) Lipp J.J. … Guthrie C. (Nat. Struct. Mol. Biol. 2015) 3 64

Products for SVOP Gene

Sources for SVOP Gene

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