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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SVOP Gene

protein-coding   GIFtS: 41
GCID: GC12M109304

SV2 related protein homolog (rat)
 Explore 1 disease affiliated with
SVOP via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SVOP    

Aliases
for SVOP gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
SV2 Related Protein Homolog (Rat)1 2
SV2-Related Protein2 3
DKFZp761H0391
Synaptic Vesicle 2-Related Protein2

External Ids:    HGNC: 254171   Entrez Gene: 555302   Ensembl: ENSG000001661117   OMIM: 6116995   UniProtKB: Q8N4V23   

Export aliases for SVOP gene to outside databases

Previous GC identifers: GC12M107808 GC12M106369


Summaries
for SVOP gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for SVOP gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_029419.12  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for SVOP
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SVOP promoter sequence
   Search SABiosciences Chromatin IP Primers for SVOP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SVOP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.11   Ensembl cytogenetic band:  12q24.11   HGNC cytogenetic band: 12q24.11

SVOP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SVOP gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M109304:  view genomic region     (about GC identifiers)

Start:
 109,304,658 bp from pter      End:
 109,459,045 bp from pter
Size:
 154,388 bases      Orientation:
 minus strand

Proteins
for SVOP gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SVOP_HUMAN, Q8N4V2 (See protein sequence)
Recommended Name: Synaptic vesicle 2-related protein  
Size: 548 amino acids; 60769 Da
Subcellular location: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein
(By similarity)
Secondary accessions: Q9NPW5

Explore the universe of human proteins at neXtProt for SVOP: NX_Q8N4V2

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8N4V2

    • SVOP Protein expression data from MOPED and PaxDb:    About this image 
    SVOP Protein Expression
    REFSEQ proteins: NP_061181.1  
    ENSEMBL proteins: 
     ENSP00000299134   ENSP00000447583   ENSP00000447275   ENSP00000449132   ENSP00000448505  
     ENSP00000446523  

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    Uscn Proteins for SVOP

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008021synaptic vesicle ISS--
    GO:0016021integral to membrane IEA--
    GO:0030054cell junction IEA--
    GO:0030672synaptic vesicle membrane IEA--

    SVOP for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for SVOP gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SVOP for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR005828 Sub_transporter
     IPR020846 MFS_dom
     IPR004749 Orgcat_transp
     IPR011701 MFS
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry Q8N4V2

    ProtoNet protein and cluster: Q8N4V2

    UniProtKB/Swiss-Prot: SVOP_HUMAN, Q8N4V2
    Similarity: Belongs to the major facilitator superfamily


    Function
    for SVOP gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015075ion transmembrane transporter activity IEA--
         
    SVOP for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SVOP 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SVOP
    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate SVOP (see all 15):
    hsa-miR-4307 hsa-miR-502-5p hsa-miR-34c-5p hsa-miR-449b hsa-miR-516b* hsa-miR-133b hsa-miR-106a* hsa-miR-449a
    SwitchGear 3'UTR luciferase reporter plasmid: SVOP 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SVOP (see all 7)
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    Gene Editing
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    Clone
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    In Situ Assay
    Products:       
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    Pathways & Interactions
    for SVOP gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SVOP

    Drugs & Compounds
    for SVOP gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for SVOP
    Search CenterWatch for drugs/clinical trials and news about SVOP 

    Transcripts
    for SVOP gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SVOP gene: 
    NM_018711.2  

    Unigene Cluster for SVOP:

    SV2 related protein homolog (rat)
    Hs.4221  [show with all ESTs]
    Unigene Representative Sequence: BC033587
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000299134(uc010sxh.1) ENST00000551211 ENST00000550436 ENST00000546618
    ENST00000548229 ENST00000551429 ENST00000550490 ENST00000550046 ENST00000551683


    miRNA
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    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate SVOP (see all 15):
    hsa-miR-4307 hsa-miR-502-5p hsa-miR-34c-5p hsa-miR-449b hsa-miR-516b* hsa-miR-133b hsa-miR-106a* hsa-miR-449a
    SwitchGear 3'UTR luciferase reporter plasmid: SVOP 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SVOP (see all 7)
    OriGene shRNA RFP: SVOP
    OriGene siRNA: SVOP
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    Clone
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    GenScript: all cDNA clones in your preferred vector: SVOP (NM_018711)
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    Primer
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    Additional cDNA sequence: 

    AK309780.1 AL359592.1 BC033587.1 BC094722.1 

    8 DOTS entries:

    DT.95235429  DT.121643541  DT.121199214  DT.100739835  DT.102822727  DT.121199212  DT.121199225  DT.65288646 

    24/33 AceView cDNA sequences (see all 33):

    BX369064 BX281815 BX953175 T15447 AA350030 AL523335 AL359592 AA351693 
    AI457841 T08271 BM725446 AW957713 BX329006 BG820031 AW663941 T08675 
    AL563357 BG056004 AA349846 BX354244 AA349847 AW173250 AW965645 BE467440 

    GeneLoc Exon Structure


    Expression
    for SVOP gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SVOP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --
    SVOP Expression
    About this image

    SVOP expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainBlood Brain BarrierEndothelial CellsBlood Brain Barrier, Endothelium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SVOP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SVOP

    SOURCE GeneReport for Unigene cluster: Hs.4221
        SABiosciences Custom PCR Arrays for SVOP
    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SVOP

    Orthologs
    for SVOP gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for SVOP gene from 8/26 species (see all 26)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SVOP1 SV2 related protein homolog (rat) 80.05(n)
    92.7(a)    		   416895  XM_415186.3  XP_415186.3 
    lizard
    (Anolis carolinensis)    		 Reptilia SVOP6
    		 --
    		 89(a)
    		 1 ↔ 1
    		 AAWZ02038876(900-4303)
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC5591621 novel protein similar to rat SV2 related protein 71.47(n)
    78.28(a)    		   559162  XM_682478.2  XP_687570.2 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG43241 CG4324 55.03(n)
    51.47(a)    		   37830  NM_138024.2  NP_611868.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea svop-11 Protein SVOP-1 54.93(n)
    55.77(a)    		   176250  NM_066559.4  NP_498960.2 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT3G130506
    		 major facilitator protein
    		 35(a)
    		 1 → many
    		 3(4176511-4179066)
    rice
    (Oryza sativa)    		 Liliopsida Os03g06382001 hypothetical protein 47.77(n)
    39.46(a)    		   4333528  NM_001057264.1  NP_001050729.1 
    E. coli
    (Escherichia coli)    		 Gamma proteobacteria mhpT6
    ygcS6
    (see all 7)    		 predicted transporter
    (see all 7)    		 22(a)
    20(a)
    (see all 7)    		 possible ortholog
    possible ortholog
    (see all 7)    		 Chromosome(374683-375894)
    Chromosome(2894555-2895892)


    ENSEMBL Gene Tree for SVOP (if available)
    TreeFam Gene Tree for SVOP (if available) 

    Paralogs
    for SVOP gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SVOP gene
    SV2B2  SV2C2  SVOPL2  SV2A2  
    7 SIMAP similar genes for SVOP using alignment to 4 protein entries:     SVOP_HUMAN (see all proteins):
    SPNS3    SV2C    SLC22A2    SVOPL    SLC22A25    UST6
    SLC22A8

    SVOP for paralogs           About GeneDecksing



    Genomic Variants
    for SVOP gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for SVOP
         1 CNV: 5312
         1 Indel: 61277
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SVOP
    DNA2.0 Custom Variant and Variant Library Synthesis for SVOP

    Disorders / Diseases
    for SVOP gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SVOP for disorders           About GeneDecksing

    OMIM gene information: 611699    OMIM disorders: --

    1 disease for SVOP:    About MalaCards
    uremia


    Export disorders for SVOP gene to outside databases

    Publications
    for SVOP gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SVOP gene integrated from 9 sources:
    (articles sorted by number of sources associating them with SVOP)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of six putative human transporters with structural similarity to the drug transporter SLC22 family. (PubMed id 17714910)1, 2 Jacobsson J.A.... Fredriksson R. (2007)
    2. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    5. SVOP is a nucleotide binding protein. (PubMed id 19390693)9 Yao J. and Bajjalieh S.M. (2009)

    External Searches for SVOP gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SVOP gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55530 HGNC: 25417 AceView: DKFZp761H039 Ensembl:ENSG00000166111 euGenes: HUgn55530
    ECgene: SVOP H-InvDB: SVOP

    Other Databases showing SVOP gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SVOP gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SVOP Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SVOP gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SVOP gene:
    Search GeneIP for patents involving SVOP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for SVOP gene

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    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     
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     OriGene Custom Antibody Services for SVOP   OriGene Custom Protein Services for SVOP  
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     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SVOP
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     GenScript Custom Purified and Recombinant Proteins Services for SVOP GenScript cDNA clones with any tag delivered in your preferred vector for SVOP
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     SVOP Proteins, Antibodies, CLIAs, and ELISAs
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     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SVOP
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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

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    VWF
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    von Willebrand factor
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