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Aliases for SVOP Gene

Aliases for SVOP Gene

  • SV2 Related Protein Homolog (Rat) 2 3
  • SV2-Related Protein 4

External Ids for SVOP Gene

Summaries for SVOP Gene

GeneCards Summary for SVOP Gene

SVOP (SV2 Related Protein Homolog (Rat)) is a Protein Coding gene. GO annotations related to this gene include ion transmembrane transporter activity. An important paralog of this gene is SV2C.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SVOP Gene

Genomics for SVOP Gene

Genomic Location for SVOP Gene

Start:
108,907,741 bp from pter
End:
109,021,240 bp from pter
Size:
113,500 bases
Orientation:
Minus strand

Genomic View for SVOP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SVOP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SVOP Gene

No data available for Regulatory Elements for SVOP Gene

Proteins for SVOP Gene

  • Protein details for SVOP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N4V2-SVOP_HUMAN
    Recommended name:
    Synaptic vesicle 2-related protein
    Protein Accession:
    Q8N4V2
    Secondary Accessions:
    • Q9NPW5

    Protein attributes for SVOP Gene

    Size:
    548 amino acids
    Molecular mass:
    60769 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SVOP Gene

Proteomics data for SVOP Gene at MOPED

Post-translational modifications for SVOP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SVOP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SVOP Gene

Domains for SVOP Gene

Protein Domains for SVOP Gene

UniProtKB/Swiss-Prot:

SVOP_HUMAN
Family:
  • Belongs to the major facilitator superfamily.:
    • Q8N4V2
genes like me logo Genes that share domains with SVOP: view

No data available for Gene Families for SVOP Gene

Function for SVOP Gene

Gene Ontology (GO) - Molecular Function for SVOP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015075 ion transmembrane transporter activity IEA --
GO:0022857 transmembrane transporter activity --
genes like me logo Genes that share ontologies with SVOP: view
genes like me logo Genes that share phenotypes with SVOP: view

Animal Models for SVOP Gene

MGI Knock Outs for SVOP:

No data available for Molecular function , Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for SVOP Gene

Localization for SVOP Gene

Subcellular locations from UniProtKB/Swiss-Prot for SVOP Gene

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SVOP Gene COMPARTMENTS Subcellular localization image for SVOP gene
Compartment Confidence
plasma membrane 3
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for SVOP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008021 synaptic vesicle ISS --
GO:0016021 integral component of membrane IEA --
GO:0030054 cell junction IEA --
GO:0030672 synaptic vesicle membrane IEA --
genes like me logo Genes that share ontologies with SVOP: view

Pathways for SVOP Gene

SuperPathways for SVOP Gene

No Data Available

Interacting Proteins for SVOP Gene

Gene Ontology (GO) - Biological Process for SVOP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0034220 ion transmembrane transport IEA --
GO:0055085 transmembrane transport --
genes like me logo Genes that share ontologies with SVOP: view

No data available for Pathways by source for SVOP Gene

Transcripts for SVOP Gene

mRNA/cDNA for SVOP Gene

Unigene Clusters for SVOP Gene

SV2 related protein homolog (rat):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SVOP Gene

No ASD Table

Relevant External Links for SVOP Gene

GeneLoc Exon Structure for
SVOP
ECgene alternative splicing isoforms for
SVOP

Expression for SVOP Gene

mRNA expression in normal human tissues for SVOP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SVOP Gene

This gene is overexpressed in Brain - Cortex (8.3), Brain - Frontal Cortex (BA9) (6.6), and Brain - Anterior cingulate cortex (BA24) (6.5).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SVOP Gene

SOURCE GeneReport for Unigene cluster for SVOP Gene Hs.4221

genes like me logo Genes that share expressions with SVOP: view

Orthologs for SVOP Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SVOP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SVOP 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SVOP 36
  • 92.09 (n)
  • 98.54 (a)
SVOP 37
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SVOP 36
  • 92.09 (n)
  • 97.99 (a)
SVOP 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Svop 36
  • 88.5 (n)
  • 95.62 (a)
Svop 16
Svop 37
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SVOP 37
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SVOP 37
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Svop 36
  • 87.71 (n)
  • 95.8 (a)
chicken
(Gallus gallus)
Aves SVOP 36
  • 80.05 (n)
  • 92.7 (a)
SVOP 37
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SVOP 37
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia svop 36
  • 76.82 (n)
  • 88.32 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.259 36
zebrafish
(Danio rerio)
Actinopterygii svopa 36
  • 71.47 (n)
  • 78.28 (a)
svopa 37
  • 70 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007660 36
  • 55.56 (n)
  • 53.76 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4324 36
  • 55.03 (n)
  • 51.47 (a)
CG4324 37
  • 47 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea svop-1 36
  • 54.88 (n)
  • 55.65 (a)
svop-1 37
  • 49 (a)
OneToOne
rice
(Oryza sativa)
Liliopsida Os03g0638200 36
  • 48.15 (n)
  • 40.14 (a)
Species with no ortholog for SVOP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SVOP Gene

ENSEMBL:
Gene Tree for SVOP (if available)
TreeFam:
Gene Tree for SVOP (if available)

Paralogs for SVOP Gene

Paralogs for SVOP Gene

Selected SIMAP similar genes for SVOP Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SVOP: view

Variants for SVOP Gene

Sequence variations from dbSNP and Humsavar for SVOP Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs747901 -- 108,993,365(+) ttatg(C/T)gtatt intron-variant
rs747902 -- 108,993,802(+) AAAAC(A/G)TGAAG intron-variant
rs1129027 -- 108,908,488(-) CCAGT(G/T)TGACC utr-variant-3-prime
rs1865146 -- 108,994,972(-) TTGAG(A/G)TGAGG intron-variant
rs1865147 -- 108,994,811(-) AATCA(A/C)CCCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SVOP Gene

Variant ID Type Subtype PubMed ID
esv2422361 CNV Duplication 17116639
nsv455711 CNV Loss 19166990
esv6912 CNV Loss 19470904
esv270200 CNV Insertion 20981092
esv1008019 CNV Loss 20482838
nsv525664 CNV Loss 19592680

Relevant External Links for SVOP Gene

HapMap Linkage Disequilibrium report
SVOP

Disorders for SVOP Gene

Relevant External Links for SVOP

Genetic Association Database (GAD)
SVOP
genes like me logo Genes that share disorders with SVOP: view

No data available for UniProtKB/Swiss-Prot for SVOP Gene

Publications for SVOP Gene

  1. Identification of six putative human transporters with structural similarity to the drug transporter SLC22 family. (PMID: 17714910) Jacobsson J.A. … Fredriksson R. (Genomics 2007) 3 4
  2. The identification of novel proteins that interact with the GLP-1 receptor and restrain its activity. (PMID: 23864651) Huang X. … Wheeler M.B. (Mol. Endocrinol. 2013) 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  4. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4
  5. SVOP is a nucleotide binding protein. (PMID: 19390693) Yao J. … Bajjalieh S.M. (PLoS ONE 2009) 23

Products for SVOP Gene

Sources for SVOP Gene

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