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Aliases for SVIP Gene

Aliases for SVIP Gene

  • Small VCP/P97-Interacting Protein 2 3 5

External Ids for SVIP Gene

Previous GeneCards Identifiers for SVIP Gene

  • GC11M022527

Summaries for SVIP Gene

Entrez Gene Summary for SVIP Gene

  • Endoplasmic reticulum-associated degradation (ERAD) is the pathway by which misfolded proteins in the endoplasmic reticulum are targeted to the proteasome for degradation. Multiple specialized proteins interact with one another during ERAD to complete this process. The protein encoded by this gene is an inhibitor of ERAD, functioning to disrupt the interaction of these protein components. This downregulation of ERAD may be needed to protect the cell from overactive protein degradation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]

GeneCards Summary for SVIP Gene

SVIP (Small VCP/P97-Interacting Protein) is a Protein Coding gene. Among its related pathways are Protein processing in endoplasmic reticulum. GO annotations related to this gene include protein self-association.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SVIP Gene

Genomics for SVIP Gene

Regulatory Elements for SVIP Gene

Promoters for SVIP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SVIP on UCSC Golden Path with GeneCards custom track

Genomic Location for SVIP Gene

Chromosome:
11
Start:
22,813,799 bp from pter
End:
22,830,299 bp from pter
Size:
16,501 bases
Orientation:
Minus strand

Genomic View for SVIP Gene

Genes around SVIP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SVIP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SVIP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SVIP Gene

Proteins for SVIP Gene

  • Protein details for SVIP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NHG7-SVIP_HUMAN
    Recommended name:
    Small VCP/p97-interacting protein
    Protein Accession:
    Q8NHG7

    Protein attributes for SVIP Gene

    Size:
    77 amino acids
    Molecular mass:
    8443 Da
    Quaternary structure:
    • Interacts (via VIM motif) with VCP.

neXtProt entry for SVIP Gene

Proteomics data for SVIP Gene at MOPED

Post-translational modifications for SVIP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SVIP Gene

No data available for DME Specific Peptides for SVIP Gene

Domains & Families for SVIP Gene

Protein Domains for SVIP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SVIP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NHG7

UniProtKB/Swiss-Prot:

SVIP_HUMAN :
  • Belongs to the SVIP family.
Family:
  • Belongs to the SVIP family.
genes like me logo Genes that share domains with SVIP: view

No data available for Gene Families for SVIP Gene

Function for SVIP Gene

Gene Ontology (GO) - Molecular Function for SVIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043621 protein self-association IMP 24055875
genes like me logo Genes that share ontologies with SVIP: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SVIP Gene

Localization for SVIP Gene

Subcellular locations from UniProtKB/Swiss-Prot for SVIP Gene

Smooth endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane; Lipid-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SVIP Gene COMPARTMENTS Subcellular localization image for SVIP gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 5
golgi apparatus 3
nucleus 3
plasma membrane 3
mitochondrion 2
cytosol 1

Gene Ontology (GO) - Cellular Components for SVIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031225 anchored component of membrane IDA 17872946
GO:0036513 colocalizes_with Derlin-1 retrotranslocation complex IDA 17872946
genes like me logo Genes that share ontologies with SVIP: view

Pathways & Interactions for SVIP Gene

genes like me logo Genes that share pathways with SVIP: view

Pathways by source for SVIP Gene

1 KEGG pathway for SVIP Gene

Gene Ontology (GO) - Biological Process for SVIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010508 positive regulation of autophagy IMP 21909394
genes like me logo Genes that share ontologies with SVIP: view

No data available for SIGNOR curated interactions for SVIP Gene

Drugs & Compounds for SVIP Gene

No Compound Related Data Available

Transcripts for SVIP Gene

mRNA/cDNA for SVIP Gene

(4) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SVIP Gene

Small VCP/p97-interacting protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SVIP Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6
SP1: - - -
SP2: -
SP3:
SP4: -

Relevant External Links for SVIP Gene

GeneLoc Exon Structure for
SVIP
ECgene alternative splicing isoforms for
SVIP

Expression for SVIP Gene

mRNA expression in normal human tissues for SVIP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SVIP Gene

This gene is overexpressed in Spinal cord (19.7), Frontal cortex (13.1), Peripheral blood mononuclear cells (10.8), and Bone (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SVIP Gene



SOURCE GeneReport for Unigene cluster for SVIP Gene Hs.349096

genes like me logo Genes that share expression patterns with SVIP: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SVIP Gene

Orthologs for SVIP Gene

This gene was present in the common ancestor of chordates.

Orthologs for SVIP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SVIP 36
  • 100 (a)
OneToOne
SVIP 35
  • 99.13 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia SVIP 35
  • 90.48 (n)
  • 89.61 (a)
dog
(Canis familiaris)
Mammalia SVIP 35
  • 90.91 (n)
  • 92.21 (a)
SVIP 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Svip 16
Svip 36
  • 81 (a)
OneToOne
Svip 35
  • 77.92 (n)
  • 80.52 (a)
oppossum
(Monodelphis domestica)
Mammalia SVIP 36
  • 29 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SVIP 36
  • 58 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Svip 35
  • 81.58 (n)
  • 82.89 (a)
chicken
(Gallus gallus)
Aves SVIP 36
  • 52 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii SVIP 36
  • 48 (a)
OneToOne
Species with no ortholog for SVIP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SVIP Gene

ENSEMBL:
Gene Tree for SVIP (if available)
TreeFam:
Gene Tree for SVIP (if available)

Paralogs for SVIP Gene

No data available for Paralogs for SVIP Gene

Variants for SVIP Gene

Sequence variations from dbSNP and Humsavar for SVIP Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs712022 -- 22,821,609(-) AGGAA(A/T)GATTG downstream-variant-500B
rs1019216 -- 22,821,674(-) GAACT(A/G)TATTT downstream-variant-500B
rs10833824 -- 22,825,939(+) CAACC(C/T)TATAT intron-variant
rs12278395 -- 22,824,902(+) gctaa(C/G)gtgga intron-variant
rs34755709 -- 22,824,508(+) ATATA(-/TA)CACAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SVIP Gene

Variant ID Type Subtype PubMed ID
nsv523451 CNV Loss 19592680
nsv524283 CNV Loss 19592680

Variation tolerance for SVIP Gene

Residual Variation Intolerance Score: 59.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.21; 4.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SVIP Gene

HapMap Linkage Disequilibrium report
SVIP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SVIP Gene

Disorders for SVIP Gene

Relevant External Links for SVIP

Genetic Association Database (GAD)
SVIP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SVIP

No disorders were found for SVIP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SVIP Gene

Publications for SVIP Gene

  1. Genome-wide association scan for survival on dialysis in African-Americans with type 2 diabetes. (PMID: 21546767) Murea M. … Freedman B.I. (Am. J. Nephrol. 2011) 3 48 67
  2. Regulation of ER-associated degradation via p97/VCP-interacting motif. (PMID: 18793143) Ballar P. … Fang S. (Biochem. Soc. Trans. 2008) 2 3
  3. Identification of SVIP as an endogenous inhibitor of endoplasmic reticulum-associated degradation. (PMID: 17872946) Ballar P. … Fang S. (J. Biol. Chem. 2007) 2 3
  4. SVIP is a novel VCP/p97-interacting protein whose expression causes cell vacuolation. (PMID: 12529442) Nagahama M. … Tagaya M. (Mol. Biol. Cell 2003) 2 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for SVIP Gene

Sources for SVIP Gene

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