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Aliases for SVIP Gene

Aliases for SVIP Gene

  • Small VCP/P97-Interacting Protein 2 3

External Ids for SVIP Gene

Previous GeneCards Identifiers for SVIP Gene

  • GC11M022527

Summaries for SVIP Gene

GeneCards Summary for SVIP Gene

SVIP (Small VCP/P97-Interacting Protein) is a Protein Coding gene. Among its related pathways are Protein processing in endoplasmic reticulum.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SVIP Gene

Genomics for SVIP Gene

Regulatory Elements for SVIP Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SVIP Gene

Start:
22,813,799 bp from pter
End:
22,830,299 bp from pter
Size:
16,501 bases
Orientation:
Minus strand

Genomic View for SVIP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SVIP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SVIP Gene

Proteins for SVIP Gene

  • Protein details for SVIP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NHG7-SVIP_HUMAN
    Recommended name:
    Small VCP/p97-interacting protein
    Protein Accession:
    Q8NHG7
    Secondary Accessions:

    Protein attributes for SVIP Gene

    Size:
    77 amino acids
    Molecular mass:
    8443 Da
    Quaternary structure:
    • Interacts (via VIM motif) with VCP.

neXtProt entry for SVIP Gene

Proteomics data for SVIP Gene at MOPED

Post-translational modifications for SVIP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SVIP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SVIP Gene

Domains for SVIP Gene

Protein Domains for SVIP Gene

ProtoNet:

Suggested Antigen Peptide Sequences for SVIP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NHG7

UniProtKB/Swiss-Prot:

SVIP_HUMAN :
  • Q8NHG7
Family:
  • Belongs to the SVIP family.
genes like me logo Genes that share domains with SVIP: view

No data available for Gene Families for SVIP Gene

Function for SVIP Gene

Gene Ontology (GO) - Molecular Function for SVIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043621 protein self-association IMP 24055875
genes like me logo Genes that share ontologies with SVIP: view

Animal Model Products

CRISPR Products

miRNA for SVIP Gene

miRTarBase miRNAs that target SVIP

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SVIP Gene

Localization for SVIP Gene

Subcellular locations from UniProtKB/Swiss-Prot for SVIP Gene

Smooth endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SVIP Gene COMPARTMENTS Subcellular localization image for SVIP gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 5
plasma membrane 5
nucleus 3
mitochondrion 2
cytosol 1
extracellular 1

Gene Ontology (GO) - Cellular Components for SVIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0000836 colocalizes_with Hrd1p ubiquitin ligase complex IDA 17872946
GO:0005789 endoplasmic reticulum membrane IDA 17872946
GO:0005794 Golgi apparatus --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with SVIP: view

Pathways for SVIP Gene

genes like me logo Genes that share pathways with SVIP: view

Pathways by source for SVIP Gene

1 KEGG pathway for SVIP Gene

Gene Ontology (GO) - Biological Process for SVIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010508 positive regulation of autophagy IMP 21909394
GO:0031333 negative regulation of protein complex assembly IMP 17872946
GO:1903061 positive regulation of protein lipidation IMP 21909394
GO:1903070 negative regulation of ER-associated ubiquitin-dependent protein catabolic process IMP 17872946
genes like me logo Genes that share ontologies with SVIP: view

Transcripts for SVIP Gene

mRNA/cDNA for SVIP Gene

(3) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SVIP Gene

Small VCP/p97-interacting protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SVIP

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SVIP
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SVIP Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6
SP1: - - -
SP2: -
SP3:
SP4: -

Relevant External Links for SVIP Gene

GeneLoc Exon Structure for
SVIP
ECgene alternative splicing isoforms for
SVIP

Expression for SVIP Gene

mRNA expression in normal human tissues for SVIP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SVIP Gene

SOURCE GeneReport for Unigene cluster for SVIP Gene Hs.349096

genes like me logo Genes that share expressions with SVIP: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SVIP Gene

Orthologs for SVIP Gene

This gene was present in the common ancestor of chordates.

Orthologs for SVIP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SVIP 35
  • 99.13 (n)
  • 100 (a)
SVIP 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SVIP 35
  • 90.48 (n)
  • 89.61 (a)
dog
(Canis familiaris)
Mammalia SVIP 35
  • 90.91 (n)
  • 92.21 (a)
SVIP 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Svip 35
  • 77.92 (n)
  • 80.52 (a)
Svip 16
Svip 36
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SVIP 36
  • 29 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SVIP 36
  • 58 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Svip 35
  • 81.58 (n)
  • 82.89 (a)
chicken
(Gallus gallus)
Aves SVIP 36
  • 52 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii SVIP 36
  • 48 (a)
OneToOne
Species with no ortholog for SVIP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SVIP Gene

ENSEMBL:
Gene Tree for SVIP (if available)
TreeFam:
Gene Tree for SVIP (if available)

Paralogs for SVIP Gene

No data available for Paralogs for SVIP Gene

Variants for SVIP Gene

Sequence variations from dbSNP and Humsavar for SVIP Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs712022 -- 22,821,609(-) AGGAA(A/T)GATTG downstream-variant-500B
rs990677 -- 22,826,882(-) CCAAA(A/C)TAAGT intron-variant
rs1019216 -- 22,821,674(-) GAACT(A/G)TATTT downstream-variant-500B
rs1132128 -- 22,827,825(-) AAAAG(A/G)GGCTG reference, missense
rs2286807 -- 22,830,206(-) AGGTA(A/G)CATGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SVIP Gene

Variant ID Type Subtype PubMed ID
nsv523451 CNV Loss 19592680
nsv524283 CNV Loss 19592680

Relevant External Links for SVIP Gene

HapMap Linkage Disequilibrium report
SVIP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SVIP Gene

Disorders for SVIP Gene

Relevant External Links for SVIP

Genetic Association Database (GAD)
SVIP
genes like me logo Genes that share disorders with SVIP: view

No data available for UniProtKB/Swiss-Prot for SVIP Gene

Publications for SVIP Gene

  1. Genome-wide association scan for survival on dialysis in African-Americans with type 2 diabetes. (PMID: 21546767) Murea M. … Freedman B.I. (Am. J. Nephrol. 2011) 3 48
  2. Identification of SVIP as an endogenous inhibitor of endoplasmic reticulum-associated degradation. (PMID: 17872946) Ballar P. … Fang S. (J. Biol. Chem. 2007) 2 3
  3. Regulation of ER-associated degradation via p97/VCP-interacting motif. (PMID: 18793143) Ballar P. … Fang S. (Biochem. Soc. Trans. 2008) 2 3
  4. SVIP is a novel VCP/p97-interacting protein whose expression causes cell vacuolation. (PMID: 12529442) Nagahama M. … Tagaya M. (Mol. Biol. Cell 2003) 2 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for SVIP Gene

Sources for SVIP Gene

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