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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SVEP1 Gene

protein-coding   GIFtS: 48
GCID: GC09M113127

Sushi, Von Willebrand Factor Type A, EGF And Pentraxin Domain...

(Previous name: chromosome 9 open reading frame 13)
(Previous symbol: C9orf13)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Sushi, Von Willebrand Factor Type A, EGF And Pentraxin Domain
Containing 11 2
     CCP Module-Containing Protein 222 3
C9orf131 2 3     POLYDOM2 5
SELOB2 3 5     Chromosome 9 Open Reading Frame 131
Selectin-Like Osteoblast-Derived Protein2 3     Selectin-Like Protein2
Serologically Defined Breast Cancer Antigen NY-BR-382 3     Sushi, Von Willebrand Factor Type A, EGF And Pentraxin Domain-Containing
Protein 12
CCP222 3     Polydom3
SEL-OB2 3     

External Ids:    HGNC: 159851   Entrez Gene: 799872   Ensembl: ENSG000001651247   OMIM: 6116915   UniProtKB: Q4LDE53   

Export aliases for SVEP1 gene to outside databases

Previous GC identifers: GC09U900662 GC09M110209 GC09M112167 GC09M082729


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SVEP1 Gene: 
SVEP1 (sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1) is a protein-coding gene. Diseases associated with SVEP1 include breast cancer, and hirschsprung's disease. GO annotations related to this gene include chromatin binding and calcium ion binding. An important paralog of this gene is DLK2.

UniProtKB/Swiss-Prot: SVEP1_HUMAN, Q4LDE5
Function: May play a role in the cell attachment process (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.2  NT_008470.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SVEP1 gene promoter:
         AhR   STAT1   Pax-2   STAT1beta   AP-4   Pax-2a   LCR-F1   STAT1alpha   Max   c-Myc   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for SVEP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SVEP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q32   Ensembl cytogenetic band:  9q31.3   HGNC cytogenetic band: 9q31-q32

SVEP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SVEP1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M113127:  view genomic region     (about GC identifiers)

Start:
113,127,528 bp from pter      End:
113,342,160 bp from pter
Size:
214,633 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SVEP1_HUMAN, Q4LDE5 (See protein sequence)
Recommended Name: Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 precursor  
Size: 3571 amino acids; 390170 Da
Subcellular location: Secreted (Potential). Cytoplasm. Membrane; Peripheral membrane protein
Sequence caution: Sequence=AAG48257.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAG48257.1; Type=Frameshift; Positions=2630, 2638, 2655; Sequence=BAB14617.1; Type=Erroneous initiation;
Note=Translation N-terminally extended; Sequence=BAB55420.1; Type=Erroneous initiation; Note=Translation
N-terminally extended; Sequence=CAH73557.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=CAH73558.1; Type=Erroneous gene model prediction; Sequence=CAH74138.1; Type=Erroneous initiation;
Note=Translation N-terminally extended; Sequence=CAH74139.1; Type=Erroneous gene model prediction;
Sequence=CAI14068.1; Type=Erroneous gene model prediction;
Secondary accessions: Q0P675 Q5D213 Q5T938 Q5VTE4 Q5VTE5 Q7Z387 Q7Z3G3 Q8NBT9 Q96JU7 Q9H284
Q9H8J9
Alternative splicing: 4 isoforms:  Q4LDE5-1   Q4LDE5-2   Q4LDE5-3   Q4LDE5-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SVEP1: NX_Q4LDE5

Explore proteomics data for SVEP1 at MOPED 

Post-translational modifications:

  • UniProtKB: O-glycosylated with core 1 or possibly core 8 glycans
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q4LDE5

  • SVEP1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SVEP1 Protein Expression
    REFSEQ proteins: NP_699197.3  
    ENSEMBL proteins: 
     ENSP00000297826   ENSP00000363593   ENSP00000363585   ENSP00000384917   ENSP00000304118  

    Human Recombinant Protein Products for SVEP1: 
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005737cytoplasm IEA--
    GO:0016020membrane IEA--

    SVEP1 for ontologies           About GeneDecksing



    SVEP1 Antibody Products: 
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    Abcam antibodies for SVEP1
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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/14 InterPro protein domains (see all 14):
     IPR011641 Tyr-kin_ephrin_A/B_rcpt-like
     IPR001881 EGF-like_Ca-bd
     IPR000742 EG-like_dom
     IPR013320 ConA-like_subgrp
     IPR009030 Growth_fac_rcpt_N_dom

    Graphical View of Domain Structure for InterPro Entry Q4LDE5

    ProtoNet protein and cluster: Q4LDE5

    2 Blocks protein domains:
    IPB001759 Pentaxin
    IPB001881 EGF-like calcium-binding


    UniProtKB/Swiss-Prot: SVEP1_HUMAN, Q4LDE5
    Similarity: Contains 9 EGF-like domains
    Similarity: Contains 2 HYR domains
    Similarity: Contains 1 pentaxin domain
    Similarity: Contains 34 Sushi (CCP/SCR) domains
    Similarity: Contains 1 VWFA domain


    SVEP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SVEP1_HUMAN, Q4LDE5
    Function: May play a role in the cell attachment process (By similarity)

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003682chromatin binding IEA--
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding ----
         
    SVEP1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for SVEP1:
     Decreased viability with pacli  Synthetic lethal with Ras 

         1 MGI phenotypic allele for Svep1 (no phenotypes)

    SVEP1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SVEP1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SVEP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SVEP1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SVEP1 

    miRNA
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    8/32 QIAGEN miScript miRNA Assays for microRNAs that regulate SVEP1 (see all 32):
    hsa-miR-495 hsa-miR-15a hsa-miR-29a hsa-miR-29c hsa-miR-767-5p hsa-miR-3074-3p hsa-miR-138-2* hsa-miR-103a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for SVEP1


    Clone
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    GenScript: all cDNA clones in your preferred vector: SVEP1 (NM_153366)
    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SVEP1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SVEP1

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5 Interacting proteins for SVEP1 (Q4LDE53 ENSP000003849174) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD3P840223, ENSP000003329734I2D: score=3 STRING: ENSP00000332973
    SKILP127573, ENSP000002591194I2D: score=5 STRING: ENSP00000259119
    SMAD9O151983, ENSP000003691544I2D: score=3 STRING: ENSP00000369154
    ZFYVE9O954053, ENSP000002877274I2D: score=3 STRING: ENSP00000287727
    ATF7IPQ6VMQ63I2D: score=3 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IEA--

    SVEP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SVEP1

    Search CenterWatch for drugs/clinical trials and news about SVEP1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SVEP1 gene: 
    NM_153366.3  

    Unigene Clusters for SVEP1:

    Sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
    Hs.522334  [show with all ESTs], Hs.726867  [show with all ESTs]
    Unigene Representative Sequences: NM_153366, BC039727
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000297826 ENST00000374469 ENST00000476205 ENST00000467821 ENST00000374461(uc004bev.3 uc004beu.2)
    ENST00000401783(uc010mty.3 uc010mtz.3) ENST00000302728(uc010mua.1)

    miRNA
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    8/32 QIAGEN miScript miRNA Assays for microRNAs that regulate SVEP1 (see all 32):
    hsa-miR-495 hsa-miR-15a hsa-miR-29a hsa-miR-29c hsa-miR-767-5p hsa-miR-3074-3p hsa-miR-138-2* hsa-miR-103a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    Clone
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SVEP1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SVEP1

    Additional mRNA sequence: 

    AK095133.1 BC039727.1 

    14 DOTS entries:

    DT.40281191  DT.101980266  DT.408476  DT.100017215  DT.447914  DT.95159539  DT.100025504  DT.121164814 
    DT.309188  DT.40231486  DT.425629  DT.95159537  DT.309187  DT.40107578 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for SVEP1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
    SP1:                                                                                                      
    SP2:              -                                                                                       


    ECgene alternative splicing isoforms for SVEP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SVEP1 expression in normal human tissues (normalized intensities)      SVEP1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTAGGGCTCT
    SVEP1 Expression
    About this image


    SVEP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/24 selected tissues (see all 24) fully expand
     
     Fibroblast
             Human Prostate Fibroblasts (HPrF)   
     
     Smooth Muscle (Muscoskeletal System)    fully expand to see all 6 entries
             Human Tracheal Smooth Muscle Cells (HTSMC)   
     
     Dermis (Uncategorized)    fully expand to see all 4 entries
             Human Dermal Fibroblasts-adult (HDF-a)   
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Mesenchymal Condensate Cells Zeugopod
             Zeugopod Periosteum
             Normal Human osteoblasts (NHOST)   
     
     Cartilage (Muscoskeletal System)    fully expand to see all 3 entries
             Mesenchymal Condensate Cells Zeugopod
             Human Annulus Fibrosus Cells (HAFC)   

    See SVEP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SVEP1

    SOURCE GeneReport for Unigene clusters: Hs.522334 Hs.726867

    UniProtKB/Swiss-Prot: SVEP1_HUMAN, Q4LDE5
    Tissue specificity: Present in mesenchymal primary cultured cell lysates (at protein level). Highly expressed in
    placenta. Also expressed in marrow stromal cell. Weakly or not expressed in other tissues

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SVEP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SVEP1 gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Svep11 , 5 sushi, von Willebrand factor type A, EGF and pentraxin more1, 5 82.68(n)1
    81.91(a)1
      4 (31.87 cM)5
    648171  NM_022814.21  NP_073725.21 
     580424425 
    chicken
    (Gallus gallus)
    Aves SVEP11 sushi, von Willebrand factor type A, EGF and pentraxin more 71.65(n)
    71.46(a)
      427338  XM_424917.3  XP_424917.3 
    lizard
    (Anolis carolinensis)
    Reptilia SVEP16
    --
    Uncharacterized protein
    66(a)
    28(a)
    1 ↔ 1
    possible ortholog
    GL343476.1(23931-165299)
    GL343255.1(1970429-1983402)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5673571 sushi, von Willebrand factor type A, EGF and pentraxin more 58.37(n)
    53.58(a)
      567357  XM_690650.5  XP_695742.5 
    fruit fly
    (Drosophila melanogaster)
    Insecta fw6
    furrowed
    22(a)
    1 → many
    X(11886948-11897943)


    ENSEMBL Gene Tree for SVEP1 (if available)
    TreeFam Gene Tree for SVEP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SVEP1 gene
    DLK22  SLIT22  SNED12  SLIT12  DLL32  JAG22  DLL42  DLK12  
    JAG12  DNER2  SLIT32  DLL12  
    6 SIMAP similar genes for SVEP1 using alignment to 3 protein entries:     SVEP1_HUMAN (see all proteins):
    NOTCH3    F9    C4BPA    DLK2    NOTCH2NL    DLK1

    SVEP1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/5179 SNPs in SVEP1 are shown (see all 5179)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs558317591,2
    C--82872809(+) AAAAA-/A/AA  
            
    GAAAG
    1 -- int11NA 2
    rs78556151,2
    C,F,H--113127040(+) ATACAA/TATTCC 1 -- ds500111Minor allele frequency- T:0.23NS EA NA WA CSA 666
    rs1918291221,2
    --113127159(+) TGGGGA/CTGTAT 1 -- ds50010--------
    rs109803451,2
    C,F,A,H--113127180(+) TTTCTT/CTTTGA 1 -- ds500110Minor allele frequency- C:0.15NS EA NA WA 756
    rs123401741,2
    C,F,H--113127215(+) tggtgC/Agatct 1 -- ds50016Minor allele frequency- A:0.07NS EA WA NA 508
    rs1847722211,2
    --113127226(+) GGGCTC/TACTGC 1 -- ds50010--------
    rs1879265521,2
    --113127237(+) AGCCTC/TGACCT 1 -- ds50010--------
    rs1931973231,2
    --113127280(+) CCCCAA/GGTAGC 1 -- ds50010--------
    rs21488741,2
    C,H--113127466(+) GCATCG/ACACCC 1 -- ds500116Minor allele frequency- A:0.02NS EA NA WA CSA 761
    rs1499547991,2
    C--113127471(+) ACACCC/TGGCTT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for SVEP1 (113127528 - 113342160 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/17 variations for SVEP1 (see all 17):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2738926CNV Deletion23290073
    esv2738924CNV Deletion23290073
    dgv1321e201CNV Deletion23290073
    esv268756CNV Insertion20981092
    nsv516479CNV Loss19592680
    nsv416225CNV Loss16902084
    nsv521593CNV Loss19592680
    esv27004CNV Loss19812545
    nsv893716CNV Loss21882294
    nsv466484CNV Loss19166990

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 611691    OMIM disorders: --

    6 diseases for SVEP1:    About MalaCards
    breast cancer    hirschsprung's disease    gout    spondylitis
    bipolar disorder    endotheliitis


    SVEP1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SVEP1
    Human Genome Epidemiology (HuGE) Navigator: SVEP1 (2 documents)

    Export disorders for SVEP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SVEP1 gene, integrated from 9 sources (see all 22):
    (articles sorted by number of sources associating them with SVEP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Polydom: a secreted protein with pentraxin, complement control protein, epidermal growth factor and von Willebrand factor A domains. (PubMed id 11062057)1, 2, 9 Gilges D....Vigon I. (2000)
    2. Genome-wide association study of lung function decline in adults with and without asthma. (PubMed id 22424883)1, 4 Imboden M....Probst-Hensch N.M. (2012)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. Fine mapping of the 9q31 Hirschsprung's disease locus . (PubMed id 20361209)1, 4 Tang C.S....Garcia-BarcelA^ M.M. (2010)
    5. Joint influence of small-effect genetic variants on h uman longevity. (PubMed id 20834067)1, 4 Yashin A.I....Ukraintseva S.V. (2010)
    6. Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. (PubMed id 18711365)1, 4 Ferreira M.A....Craddock N. (2008)
    7. Molecular and cellular characterization of SEL-OB/SVEP1 in osteogenic cells in vivo and in vitro. (PubMed id 16206243)1, 2 Shur I.... Benayahu D. (2006)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    9. Exploring genome-wide - dietary heme iron intake inter actions and the risk of type 2 diabetes. (PubMed id 23386860)1 Pasquale L.R....Hu F.B. (2013)
    10. Evaluation of various endothelial biomarkers in ankylo sing spondylitis. (PubMed id 21556780)1 Taylan A....Akkoc N. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79987 HGNC: 15985 Ensembl:ENSG00000165124 euGenes: HUgn79987 ECgene: SVEP1
    H-InvDB: SVEP1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SVEP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SVEP1 gene:
    Search GeneIP for patents involving SVEP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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