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Aliases for SVBP Gene

Aliases for SVBP Gene

  • Small Vasohibin Binding Protein 2 3 5
  • Coiled-Coil Domain Containing 23 2 3
  • CCDC23 3 4
  • Coiled-Coil Domain-Containing Protein 23 3
  • Coiled Coil Domain-Containing Protein 23 4
  • Small Vasohibin-Binding Protein 3

External Ids for SVBP Gene

Previous HGNC Symbols for SVBP Gene

  • CCDC23

Summaries for SVBP Gene

GeneCards Summary for SVBP Gene

SVBP (Small Vasohibin Binding Protein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SVBP Gene

  • Enhances the solubility and secretion of VASH1 and prevents its ubiquitination. Also enhances secretion of VASH2.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SVBP Gene

Genomics for SVBP Gene

Regulatory Elements for SVBP Gene

Enhancers for SVBP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F042815 0.7 ENCODE 38.8 +0.3 330 2.5 HDGF MLX SIN3A ARID4B DMAP1 ZNF2 YY1 ZNF143 KLF13 SP3 SVBP PPIH LOC105378682 ZNF691 P3H1 SLC2A1-AS1 ERMAP GC01M042733
GH01F042784 0.8 FANTOM5 Ensembl 38.2 +32.0 32048 1.3 PKNOX1 ATF3 HNF4G ZBTB33 RAD21 YY1 NR2F2 SVBP ZMYND12 CFAP57 YBX1 TMEM269 GC01M042733
GH01F042764 1 ENCODE 35.6 +50.9 50938 4.0 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 SVBP PPIH SZT2 LOC105378687 P3H1 ZNF691 GC01M042742
GH01F042598 0.5 FANTOM5 18.9 +219.1 219149 0.4 RFX1 RFX3 ZBTB26 SVBP ENSG00000236180 RNU6-536P PPIH P3H1 YBX1 CLDN19 CCDC30 RIMKLA GC01M042626
GH01F042419 0.2 ENCODE 16.8 +396.9 396895 2.6 FEZF1 ZIC2 RAD21 ZNF316 ZBTB48 PATZ1 PRDM10 MAFK NFIA L3MBTL2 ZMYND12 SVBP PPIH PPCS RNU6-536P ENSG00000236180 CLDN19 YBX1 PIR31959
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SVBP on UCSC Golden Path with GeneCards custom track

Promoters for SVBP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001519652 188 1601 MLX SIN3A ARID4B DMAP1 ZNF2 YY1 ZNF143 KLF13 SP3 SP5
ENSR00001744263 1487 200 GATAD2A SOX5 SOX13 HDGF SP5 CEBPB CEBPG ZNF644 YY1 NFIL3

Genomic Location for SVBP Gene

Chromosome:
1
Start:
42,807,052 bp from pter
End:
42,817,388 bp from pter
Size:
10,337 bases
Orientation:
Minus strand

Genomic View for SVBP Gene

Genes around SVBP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SVBP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SVBP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SVBP Gene

Proteins for SVBP Gene

  • Protein details for SVBP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N300-SVBP_HUMAN
    Recommended name:
    Small vasohibin-binding protein
    Protein Accession:
    Q8N300
    Secondary Accessions:
    • A8K5P1
    • D3DPW7

    Protein attributes for SVBP Gene

    Size:
    66 amino acids
    Molecular mass:
    7808 Da
    Quaternary structure:
    • Interacts with VASH1 and VASH2.

neXtProt entry for SVBP Gene

Post-translational modifications for SVBP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SVBP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SVBP Gene

Domains & Families for SVBP Gene

Protein Domains for SVBP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SVBP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N300

UniProtKB/Swiss-Prot:

SVBP_HUMAN :
  • Belongs to the SVBP family.
Family:
  • Belongs to the SVBP family.
genes like me logo Genes that share domains with SVBP: view

No data available for Gene Families for SVBP Gene

Function for SVBP Gene

Molecular function for SVBP Gene

UniProtKB/Swiss-Prot Function:
Enhances the solubility and secretion of VASH1 and prevents its ubiquitination. Also enhances secretion of VASH2.
genes like me logo Genes that share phenotypes with SVBP: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SVBP Gene

Localization for SVBP Gene

Subcellular locations from UniProtKB/Swiss-Prot for SVBP Gene

Secreted. Note=Detected both intracellularly and extracellularly. Within cells, localizes mainly to the apical part of the cell. {ECO:0000250 UniProtKB:Q99LQ4}.

Gene Ontology (GO) - Cellular Components for SVBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0045177 apical part of cell IDA 20736312
genes like me logo Genes that share ontologies with SVBP: view

No data available for Subcellular locations from COMPARTMENTS for SVBP Gene

Pathways & Interactions for SVBP Gene

SuperPathways for SVBP Gene

No Data Available

Interacting Proteins for SVBP Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000361599%0d%0a9606.ENSP00000167106%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000361599 Q8N300-SVBP_HUMAN for SVBP Gene via STRING IID

Gene Ontology (GO) - Biological Process for SVBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009306 protein secretion IDA 20736312
GO:0010596 negative regulation of endothelial cell migration IGI 20736312
GO:0031397 negative regulation of protein ubiquitination IDA 20736312
genes like me logo Genes that share ontologies with SVBP: view

No data available for Pathways by source and SIGNOR curated interactions for SVBP Gene

Transcripts for SVBP Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SVBP Gene

No ASD Table

Relevant External Links for SVBP Gene

GeneLoc Exon Structure for
SVBP
ECgene alternative splicing isoforms for
SVBP

Expression for SVBP Gene

NURSA nuclear receptor signaling pathways regulating expression of SVBP Gene:

SVBP
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for SVBP Gene

Orthologs for SVBP Gene

This gene was present in the common ancestor of chordates.

Orthologs for SVBP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC23 34 35
  • 100 (n)
cow
(Bos Taurus)
Mammalia CCDC23 34 35
  • 94.44 (n)
dog
(Canis familiaris)
Mammalia CCDC23 34 35
  • 94.44 (n)
rat
(Rattus norvegicus)
Mammalia Ccdc23 34
  • 90.4 (n)
mouse
(Mus musculus)
Mammalia Ccdc23 34 35
  • 89.39 (n)
Svbp 16
oppossum
(Monodelphis domestica)
Mammalia CCDC23 35
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCDC23 35
  • 70 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CCDC23 35
  • 68 (a)
OneToOne
Species where no ortholog for SVBP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SVBP Gene

ENSEMBL:
Gene Tree for SVBP (if available)
TreeFam:
Gene Tree for SVBP (if available)

Paralogs for SVBP Gene

No data available for Paralogs for SVBP Gene

Variants for SVBP Gene

Sequence variations from dbSNP and Humsavar for SVBP Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1044898 -- 42,807,170(-) TTTTT(A/T)AAAAA utr-variant-3-prime
rs1108734 -- 42,812,571(-) ACCAG(A/G)GGAGG intron-variant
rs111289693 -- 42,808,973(+) ATTAC(A/G)GGCGT intron-variant
rs111428896 -- 42,816,425(+) CTTAA(C/T)CTCAC intron-variant, upstream-variant-2KB
rs111785516 -- 42,814,225(+) ACAGG(-/C)GAGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SVBP Gene

Variant ID Type Subtype PubMed ID
esv2668067 CNV deletion 23128226
esv3577249 CNV gain 25503493
esv3585854 CNV loss 21293372

Variation tolerance for SVBP Gene

Residual Variation Intolerance Score: 54.2% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SVBP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SVBP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SVBP Gene

Disorders for SVBP Gene

Relevant External Links for SVBP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SVBP

No disorders were found for SVBP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SVBP Gene

Publications for SVBP Gene

  1. Isolation of a small vasohibin-binding protein (SVBP) and its role in vasohibin secretion. (PMID: 20736312) Suzuki Y. … Sato Y. (J. Cell. Sci. 2010) 2 3 4 64
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Vasohibin 2 is transcriptionally activated and promotes angiogenesis in hepatocellular carcinoma. (PMID: 22614011) Xue X. … Kondo Y. (Oncogene 2013) 3 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64

Products for SVBP Gene

Sources for SVBP Gene

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